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1. Author Correction: Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Author

Millat-Martinez, Pere, Gharbharan, Arvind, Alemany, Andrea, Rokx, Casper, Geurtsvankessel, Corine, Papageorgiou, Grigorios, van Geloven, Nan, Jordans, Carlijn, Groeneveld, Geert, Swaneveld, Francis, van der Schoot, Ellen, Corbacho-Monné, Marc, Ouchi, Dan, Piccolo Ferreira, Francini, Malchair, Pierre, Videla, Sebastian, García García, Vanesa, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodriguez Codina, Joana, Amado Simon, Rosa, Grifols, Joan-Ramon, Blanco, Julian, Blanco, Ignacio, Ara, Jordi, Bassat, Quique, Clotet, Bonaventura, Baro, Bàrbara, Troxel, Andrea, Zwaginga, Jaap Jan, Mitjà, Oriol, and Rijnders, Bart J. A.

Published
2024
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3. Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Author

Millat-Martinez, Pere, Gharbharan, Arvind, Alemany, Andrea, Rokx, Casper, Geurtsvankessel, Corine, Papageorgiou, Grigorios, van Geloven, Nan, Jordans, Carlijn, Groeneveld, Geert, Swaneveld, Francis, van der Schoot, Ellen, Corbacho-Monné, Marc, Ouchi, Dan, Piccolo Ferreira, Francini, Malchair, Pierre, Videla, Sebastian, García García, Vanesa, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodriguez Codina, Joana, Amado Simon, Rosa, Grifols, Joan-Ramon, Blanco, Julian, Blanco, Ignacio, Ara, Jordi, Bassat, Quique, Clotet, Bonaventura, Baro, Bàrbara, Troxel, Andrea, Zwaginga, Jaap Jan, Mitjà, Oriol, and Rijnders, Bart J. A.

Published
2022
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4. Sustained seropositivity up to 20.5 months after COVID-19

Author

Dobaño, Carlota, Ramírez-Morros, Anna, Alonso, Selena, Rubio, Rocío, Ruiz-Olalla, Gemma, Vidal-Alaball, Josep, Macià, Dídac, Catalina, Queralt Miró, Vidal, Marta, Casanovas, Aina Fuster, Prados de la Torre, Esther, Barrios, Diana, Jiménez, Alfons, Zanoncello, Jasmina, Melero, Natalia Rodrigo, Carolis, Carlo, Izquierdo, Luis, Aguilar, Ruth, Moncunill, Gemma, and Ruiz-Comellas, Anna

Published
2022
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5. High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

Author

Ferrer, Susana, Gallardo, Mireia, Ubals, Maria, González-Beiras, Camila, Vall-Mayans, Martí, Suñer, Clara, Laporte-Villar, Clàudia, Nieto, Aroa, Comas-Leon, Xavier, Jiménez, Zahida, Ramírez-Viaplana, Ferran, Delgado-Capel, Maria, Díez Sánchez, Beatriz, Pons Barber, Maria, Gonzalez Ruiz, Cristian, Navarrete Gonzalez, Laura, González García, David, Vivero Larraza, Ainhoa, Carceles Peiró, Victor, Roquer López, Clàudia, Robert, Neus, Palet, Carles, Gudiol, Carlota, Casares Gonzalez, Pablo, Arcos Vila, Gemma, Flores Aguilera, Begoña, Rodríguez-Sevilla, Graciela, Dastis Arias, Macarena, Roca Font, Judit, Carrasco Matos, Katherine M., Saüch Valmaña, Glòria, Vidal Obradors, Carla, Tarres García, Silvia, Curriu Sabatès, Margarida, Nieto Rodríguez, Raquel, Línio, Rosa, Fornos, Míriam, Casamitjana, Natàlia, Alonso, Eva, Martínez, Núria, Maglio, Laura Analía, Comellas Fernandez, Laura, Garcia, Nadia, Hernández, Luis, González, Maria Isabel, Bravo, Anna, García, Yolanda, Sauleda Oliveras, Silvia, Vertiz, Tatiana, Benavent, Sergio, Bianco, Andrea Sofia, Verdaguer, Joaquim, Briones Zambrano, Ney Nicanor, Viozquez Meya, Maria, Hernández, Águeda, Casaña Lopez, Cristina, Bordoy, Antoni E., González Soler, Victoria, Giménez, Montserrat, París, Alexa, Marfil, Silvia, Trinité, Benjamin, Grau, Eulàlia, Alemany, Andrea, Millat-Martinez, Pere, Corbacho-Monné, Marc, Malchair, Pierre, Ouchi, Dan, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodríguez Codina, Joana, Amado Simon, Rosa, Videla, Sebastian, Costes, Gèlia, Capdevila-Jáuregui, Mar, Torrano-Soler, Pamela, San José, Alba, Bonet Papell, Glòria, Puig, Jordi, Otero, Aurema, Ruibal Suarez, Jose Carlos, Zarauza Pellejero, Alvaro, Llopis Roca, Ferran, Rodriguez Cortez, Orlando, Garcia Garcia, Vanesa, Vidal-Alaball, Josep, Millan, Anna, Contreras, Enric, Grifols, Joan-Ramon, Ancochea, Àgueda, Galvan-Femenia, Ivan, Piccolo Ferreira, Francini, Bonet, Mireia, Cantoni, Jordi, Prat, Núria, Ara, Jordi, Forcada Arcarons, Anna, Farré, Magí, Pradenas, Edwards, Blanco, Julià, Àngel Rodriguez-Arias, Miquel, Fernández Rivas, Gema, Marks, Michael, Bassat, Quique, Blanco, Ignacio, Baro, Bàrbara, Clotet, Bonaventura, and Mitjà, Oriol

Published
2022
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6. Impact of Gender on Patient Experiences of Self-Management in Type 2 Diabetes: A Qualitative Study.

Author

Ramírez-Morros, Anna, Berenguera, Anna, Millaruelo, Laura, Buil-Cosiales, Pilar, Garcia, Carmen Gomez, Cos, Xavier, Lachica, Luis Ávila, Artola, Sara, Millaruelo, Jose Manuel, Mauricio, Didac, and Franch-Nadal, Josep

Subjects
*TYPE 2 diabetes, *FAMILY support, *GENDER differences (Sociology), *GENDER inequality, *RISK-taking behavior
Abstract

Purpose: This study aims to identify gender disparities in knowledge, attitudes and behaviors related to self-management and control of Type 2 diabetes Mellitus (T2DM) among primary care patients. The research was conducted across multiple Spanish cities. Patients and Methods: The study involved 8 Primary Care Centres located in four distinct regions of Spain: East (Barcelona), Centre (Madrid), North (Pamplona and Zumaia) and South (Vélez-Málaga and Málaga). A total of 111 individuals diagnosed with T2DM, comprising 52 women and 59 men, participated in 12 group discussions at these primary healthcare centers from February to June 2015. Participation was voluntary, and all participants provided informed consent by signing the consent form. A qualitative hermeneutic phenomenological study with a maximum variation sample was done. Participant profiles were defined based on gender, age, place of residence, type of treatment, years living with T2DM and the presence or absence of a cardiovascular event. Thematic analysis was used to analyze the data. Results: Participants were aware that diabetes is a chronic condition, with varied levels of concern regarding the diagnosis. Participants' locus of control influenced their perception of the disease's cause, with women attributing it to stress and emotional situations, while men linked it to risky behaviors. Self-management strategies were shaped by beliefs about diabetes, with both genders facing challenges in implementing recommended practices. Gender differences were also evident in caregiving roles, with men receiving more family support for diet adherence, while women prioritized family needs over their self-care. Participants expressed satisfaction with professional-patient interactions but highlighted the need for more accessible information and specialist care, suggesting support groups for women and clear health guidelines for men. Conclusion: Gender differences significantly influence how patients perceive and manage type 2 diabetes, with women experiencing greater concern and care burden compared to men. Effective diabetes management requires tailored support that addresses these gender-specific challenges. Enhancing healthcare services with clear guidelines and support groups can improve self-management outcomes in both men and women. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Malaria and other infections induce polyreactive antibodies that impact SARS‐CoV‐2 seropositivity estimations in endemic settings.

Author

Aguilar, Ruth, Jiménez, Alfons, Santano, Rebeca, Vidal, Marta, Maiga‐Ascofare, Oumou, Strauss, Ricardo, Bonney, Joseph, Agbogbatey, Melvin, Goovaerts, Odin, Boham, Eric E. A., Adu, Evan A., Cuamba, Inocencia, Ramírez‐Morros, Anna, Dutta, Sheetij, Angov, Evelina, Zhan, Bin, Izquierdo, Luis, Santamaria, Pere, Mayor, Alfredo, and Gascón, Joaquim

Subjects
COVID-19, SEROCONVERSION, SARS-CoV-2, MALARIA, IMMUNOGLOBULINS
Abstract

Anti‐severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) seroprevalence is used to estimate the proportion of individuals within a population previously infected, to track viral transmission, and to monitor naturally and vaccine‐induced immune protection. However, in sub‐Saharan African settings, antibodies induced by higher exposure to pathogens may increase unspecific seroreactivity to SARS‐CoV‐2 antigens, resulting in false positive responses. To investigate the level and type of unspecific seroreactivitiy to SARS‐CoV‐2 in Africa, we measured immunoglobulin G (IgG), IgA, and IgM to a broad panel of antigens from different pathogens by Luminex in 602 plasma samples from African and European subjects differing in coronavirus disease 2019, malaria, and other exposures. Seroreactivity to SARS‐CoV‐2 antigens was higher in prepandemic African than in European samples and positively correlated with antibodies against human coronaviruses, helminths, protozoa, and especially Plasmodium falciparum. African subjects presented higher levels of autoantibodies, a surrogate of polyreactivity, which correlated with P. falciparum and SARS‐CoV‐2 antibodies. Finally, we found an improved sensitivity in the IgG assay in African samples when using urea as a chaotropic agent. In conclusion, our data suggest that polyreactive antibodies induced mostly by malaria are important mediators of the unspecific anti‐SARS‐CoV‐2 responses, and that the use of dissociating agents in immunoassays could be useful for more accurate estimates of SARS‐CoV‐2 seroprevalence in African settings. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Persistence and baseline determinants of seropositivity and reinfection rates in health care workers up to 12.5 months after COVID-19

Author

Dobaño, Carlota, Ramírez-Morros, Anna, Alonso, Selena, Vidal-Alaball, Josep, Ruiz-Olalla, Gemma, Vidal, Marta, Rubio, Rocío, Cascant, Emma, Parras, Daniel, Rodrigo Melero, Natalia, Serra, Pau, Carolis, Carlo, Santamaria, Pere, Forcada, Anna, Mendioroz, Jacobo, Aguilar, Ruth, Moncunill, Gemma, and Ruiz-Comellas, Anna

Published
2021
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14. Eleven‐month longitudinal study of antibodies in SARS‐CoV‐2 exposed and naïve primary health care workers upon COVID‐19 vaccination

Author

Dobaño, Carlota, primary, Ramírez‐Morros, Anna, additional, Alonso, Selena, additional, Ruiz‐Olalla, Gemma, additional, Rubio, Rocío, additional, Vidal, Marta, additional, Prados de la Torre, Esther, additional, Jairoce, Chenjerai, additional, Mitchell, Robert A., additional, Barrios, Diana, additional, Jiménez, Alfons, additional, Rodrigo Melero, Natalia, additional, Carolis, Carlo, additional, Izquierdo, Luis, additional, Zanoncello, Jasmina, additional, Aguilar, Ruth, additional, Vidal‐Alaball, Josep, additional, Moncunill, Gemma, additional, and Ruiz‐Comellas, Anna, additional

Published
2022
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16. Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Author

Rokx, Casper, Lammers, Jolanda, Buitenhuis, Lonneke, Postma, Douwe, Koster, David, Lukens, Michaèl, Scholtens, Thea, Boomgaard, Maartje van den, Kampschreur, Linda, Ubals, Maria, Prat, Núria, Díez Sánchez, Beatriz, Vértiz Guidotti, Thatiana, Pons Barber, Maria, Gonzalez Ruiz, Cristian, Navarrete Gonzalez, Laura, Ancochea, Àgueda, Ferrer, Magí, Videla, Sebas, Gudiol, Carlota, Fernández Rivas, Gema, CoV-Early Study Group, Vonderen, Marit van, Bianco, Andrea Sofia, Bravo, Anna, Otero, Aurema, Ruibal Suarez, Jose Carlos, Benavent, Sergio, Zarauza Pellejero, Alvaro, Línio, Rosa, Malchair, Pierre, Llopis Roca, Ferran, Blanco, Julian, Rodriguez Cortez, Orlando, Casares Gonzalez, Pablo, Arcos Vila, Gemma, García, Yolanda, Roca Font, Judit, Carrasco Matos, Katherine M., Saüch Valmaña, Glòria, Vidal Obradors, Carla, Koopmans, Marion, Ara, Jordi, COnV-ert Study Group, Rodríguez Codina, Joana, Tarres García, Silvia, Blanco, Ignacio, Hernández, Águeda, González Soler, Victoria, Curriu Sabatès, Margarida, Nieto Rodríguez, Raquel, Grífols, Joan Ramon, Briones Zambrano, Ney Nicanor, Millan, Anna, Capdevila Jáuregui, Mar, Fornos, Miriam, Casamitjana, Natàlia, Bordoy, Antoni E., Alonso, Eva, Zwet, Erik van, Miedema, Jelle, Martinez, Núria, Ramírez Morros, Anna, Bogers, Susanne, Maglio, Laura Analía, Amado Simon, Rosa, Comellas Fernandez, Laura, Garcia, Nadia, Ruiz Comellas, Anna, Baro, Bàrbara, Hernández, Luis, Viozquez Meya, Maria, Costes, Gèlia, Pradenas, Edwars, Forcada, Anna, Ginneken, Betty van, Harvala, Heli, Marfil, Silvia, Troxel, Andrea, Mooijaart, Simon, Trinité, Benjamin, Piccolo Ferreira, Francini, Bonet, Mireia, Cantoni, Jordi, Russcher, Henk, Marks, Michael, Zwaginga, Jaap Jan, Torrano Soler, Pamela, Mitjà, Oriol, Rijnders, Bart J. A., Droog, José de, Corbacho Monné, Marc, Scherpenisse, Cees, Hollander, Jan den, Gharbharan, Arvind, Jordans, Carlijn, Geurtsvankessel, Corine, Albersen, Arjan, Papageourgiou, Grigorios, Katsikis, Peter, Vall Mayans, Martí, Müller, Yvonne, Reusken, Chantal, San José, Alba, Ferrer, Susana, Engen, Rene van, Karisli, Ayten, Götz, Hannelore, Struik, Jelle, París, Alexa, Suñer Navarro, Clara, Clotet, Bonaventura, 1953, Reimerink, Johan, Rokx-Niemantsverdriet, Lotte, Rodriguez Arias, Miquel Angel, Jiménez, Zahida, Verstijnen, Jose, Geloven, Nan van, Groeneveld, Geert, Zwaginga, Lisa, Oud, Josine, Meier, Romy, González Beiras, Camila, Swaneveld, Francis, Ramírez Viaplana, Ferran, Schoot, Ellen van der, Vrielink, Hans, Flores Aguilera, Begoña, Vivero Larraza, Ainhoa, Watering, Leo van de, Hogema, Boris, González García, David, Wijngaarden, Peter van, Vidal Alaball, Josep, Etten, Ronald van, Gammeren, Adriaan van, Alemany, Andrea, Puig, Jordi, Maas, Nanda, Berg – Rahman, Juliette van der, Karim, Faiz, Hiddema, Siepke, Elst, Kim van, García García, Vanesa, Casañ Lopez, Cristina, Leeuwen-Segarceanu, Elena van, Nieto, Aroa, Rodríguez Sevilla, Graciela, Reitsma, Annette, Molenkamp, Karin, Soetekouw, Robert, Band, Caterina, Carceles Peiró, Victor, Gallardo, Mireia, Galvan Femenia, Ivan, Comas Leon, Xavier, Millat Martínez, Pere, Bassat Orellana, Quique, González, María Isabel, Verdaguer, Joaquim, Roquer López, Clàudia, Contreras, Enric, Giménez, Montserrat, Ouchi, Dan, Blanco Guillermo, Ignacio, Bonet Papell, Glòria, Dastis Arias, Macarena, Delgado Capel, Maria, Faculteit Medische Wetenschappen/UMCG, Internal Medicine, Medical Microbiology & Infectious Diseases, Virology, and Epidemiology

Subjects
Immunoregulació, Multidisciplinary, SARS-CoV-2, Immunization, Passive, Immunoregulation, COVID-19, General Physics and Astronomy, Bayes Theorem, General Chemistry, Middle Aged, General Biochemistry, Genetics and Molecular Biology, Treatment Outcome, Outpatients, Humans, Multicenter Studies as Topic, COVID-19 Serotherapy, Randomized Controlled Trials as Topic
Abstract

Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when Trial registration: Clinicaltrials.gov NCT04621123 and NCT04589949. Registration: NCT04621123 and NCT04589949 on https://www.clinicaltrials.gov

Published
2022

19. High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

Author

Alemany, Andrea, primary, Millat-Martinez, Pere, additional, Corbacho-Monné, Marc, additional, Malchair, Pierre, additional, Ouchi, Dan, additional, Ruiz-Comellas, Anna, additional, Ramírez-Morros, Anna, additional, Rodríguez Codina, Joana, additional, Amado Simon, Rosa, additional, Videla, Sebastian, additional, Costes, Gèlia, additional, Capdevila-Jáuregui, Mar, additional, Torrano-Soler, Pamela, additional, San José, Alba, additional, Bonet Papell, Glòria, additional, Puig, Jordi, additional, Otero, Aurema, additional, Ruibal Suarez, Jose Carlos, additional, Zarauza Pellejero, Alvaro, additional, Llopis Roca, Ferran, additional, Rodriguez Cortez, Orlando, additional, Garcia Garcia, Vanesa, additional, Vidal-Alaball, Josep, additional, Millan, Anna, additional, Contreras, Enric, additional, Grifols, Joan-Ramon, additional, Ancochea, Àgueda, additional, Galvan-Femenia, Ivan, additional, Piccolo Ferreira, Francini, additional, Bonet, Mireia, additional, Cantoni, Jordi, additional, Prat, Núria, additional, Ara, Jordi, additional, Forcada Arcarons, Anna, additional, Farré, Magí, additional, Pradenas, Edwards, additional, Blanco, Julià, additional, Àngel Rodriguez-Arias, Miquel, additional, Fernández Rivas, Gema, additional, Marks, Michael, additional, Bassat, Quique, additional, Blanco, Ignacio, additional, Baro, Bàrbara, additional, Clotet, Bonaventura, additional, Mitjà, Oriol, additional, Ferrer, Susana, additional, Gallardo, Mireia, additional, Ubals, Maria, additional, González-Beiras, Camila, additional, Vall-Mayans, Martí, additional, Suñer, Clara, additional, Laporte-Villar, Clàudia, additional, Nieto, Aroa, additional, Comas-Leon, Xavier, additional, Jiménez, Zahida, additional, Ramírez-Viaplana, Ferran, additional, Delgado-Capel, Maria, additional, Díez Sánchez, Beatriz, additional, Pons Barber, Maria, additional, Gonzalez Ruiz, Cristian, additional, Navarrete Gonzalez, Laura, additional, González García, David, additional, Vivero Larraza, Ainhoa, additional, Carceles Peiró, Victor, additional, Roquer López, Clàudia, additional, Robert, Neus, additional, Palet, Carles, additional, Gudiol, Carlota, additional, Casares Gonzalez, Pablo, additional, Arcos Vila, Gemma, additional, Flores Aguilera, Begoña, additional, Rodríguez-Sevilla, Graciela, additional, Dastis Arias, Macarena, additional, Roca Font, Judit, additional, Carrasco Matos, Katherine M., additional, Saüch Valmaña, Glòria, additional, Vidal Obradors, Carla, additional, Tarres García, Silvia, additional, Curriu Sabatès, Margarida, additional, Nieto Rodríguez, Raquel, additional, Línio, Rosa, additional, Fornos, Míriam, additional, Casamitjana, Natàlia, additional, Alonso, Eva, additional, Martínez, Núria, additional, Maglio, Laura Analía, additional, Comellas Fernandez, Laura, additional, Garcia, Nadia, additional, Hernández, Luis, additional, González, Maria Isabel, additional, Bravo, Anna, additional, García, Yolanda, additional, Sauleda Oliveras, Silvia, additional, Vertiz, Tatiana, additional, Benavent, Sergio, additional, Bianco, Andrea Sofia, additional, Verdaguer, Joaquim, additional, Briones Zambrano, Ney Nicanor, additional, Viozquez Meya, Maria, additional, Hernández, Águeda, additional, Casaña Lopez, Cristina, additional, Bordoy, Antoni E., additional, González Soler, Victoria, additional, Giménez, Montserrat, additional, París, Alexa, additional, Marfil, Silvia, additional, Trinité, Benjamin, additional, and Grau, Eulàlia, additional

Published
2022
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20. Additional file 1 of Sustained seropositivity up to 20.5 months after COVID-19

Author

Dobaño, Carlota, Ramírez-Morros, Anna, Alonso, Selena, Rubio, Rocío, Ruiz-Olalla, Gemma, Vidal-Alaball, Josep, Macià, Dídac, Catalina, Queralt Miró, Vidal, Marta, Casanovas, Aina Fuster, Prados de la Torre, Esther, Barrios, Diana, Jiménez, Alfons, Zanoncello, Jasmina, Melero, Natalia Rodrigo, Carolis, Carlo, Izquierdo, Luis, Aguilar, Ruth, Moncunill, Gemma, and Ruiz-Comellas, Anna

Abstract

Additional file 1: Table S1. Association of baseline variables and comorbidities with levels of SARS-CoV-2 antibodies at time point 4 (January-February 2021) prior to the massive rollout of vaccination. Table S2. Seropositivity against the SARS-CoV-2 receptor-binding domain antigen from variants of concern. Table S3. Reinfections. Table S4. Significant associations of baseline variables with differential antibody rate of change. Fig. S1. Overall distribution of antibody responses for each isotype and antigen pair of the 128 pre-pandemic samples (negative controls) along with the cutoffs.

Published
2022
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21. Additional file 1 of Persistence and baseline determinants of seropositivity and reinfection rates in health care workers up to 12.5 months after COVID-19

Author

Dobaño, Carlota, Ramírez-Morros, Anna, Alonso, Selena, Vidal-Alaball, Josep, Ruiz-Olalla, Gemma, Vidal, Marta, Rubio, Rocío, Cascant, Emma, Parras, Daniel, Rodrigo Melero, Natalia, Serra, Pau, Carolis, Carlo, Santamaria, Pere, Forcada, Anna, Mendioroz, Jacobo, Aguilar, Ruth, Moncunill, Gemma, and Ruiz-Comellas, Anna

Abstract

Additional file 1: Table S1. Baseline characteristics cohort.

Published
2021
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22. Role of the Scavenger Receptor CD36 in Accelerated Diabetic Atherosclerosis

Author

Navas Madroñal, Miquel, Castelblanco, Esmeralda, Camacho, Mercedes, Consegal, Marta, Ramírez-Morros, Anna, Sarrias, Maria-Rosa, Perez, Paulina, Alonso, Núria, Galán, María, Mauricio Puente, Dídac, and Universitat Autònoma de Barcelona

Subjects
0301 basic medicine, CD36 Antigens, Male, Vascular smooth muscle, CD36, 030204 cardiovascular system & hematology, Muscle, Smooth, Vascular, lcsh:Chemistry, 0302 clinical medicine, lcsh:QH301-705.5, Spectroscopy, Vascular calcification, Medial arterial calcification, Receptors, Scavenger, biology, diabetes, Chemistry, Diabetes, Calcinosis, General Medicine, Middle Aged, Flow Cytometry, Computer Science Applications, Lipoproteins, LDL, vascular calcification, cardiology, Female, lipids (amino acids, peptides, and proteins), medicine.symptom, scavenger receptor CD36, medicine.medical_specialty, Myocytes, Smooth Muscle, Inflammation, Catalysis, Article, Inorganic Chemistry, Diabetes Complications, 03 medical and health sciences, Diabetes mellitus, Internal medicine, Diabetes Mellitus, medicine, Humans, Physical and Theoretical Chemistry, Scavenger receptor, Molecular Biology, Aged, business.industry, Organic Chemistry, medicine.disease, Atherosclerosis, Scavenger receptor CD36, 030104 developmental biology, Glucose, Endocrinology, lcsh:Biology (General), lcsh:QD1-999, inflammation, Hyperglycemia, Unfolded protein response, biology.protein, atherosclerosis, business, Calcification, Lipoprotein
Abstract

Diabetes mellitus entails increased atherosclerotic burden and medial arterial calcification, but the precise mechanisms are not fully elucidated. We aimed to investigate the implication of CD36 in inflammation and calcification processes orchestrated by vascular smooth muscle cells (VSMCs) under hyperglycemic and atherogenic conditions. We examined the expression of CD36, pro-inflammatory cytokines, endoplasmic reticulum (ER) stress markers, and mineralization-regulating enzymes by RT-PCR in human VSMCs, cultured in a medium containing normal (5 mM) or high glucose (22 mM) for 72 h with or without oxidized low-density lipoprotein (oxLDL) (24 h). The uptake of 1,1&prime, dioctadecyl-3,3,3&prime, 3-tetramethylindocarbocyanine perchlorate-fluorescently (DiI) labeled oxLDL was quantified by flow cytometry and fluorimetry and calcification assays were performed in VSMC cultured in osteogenic medium and stained by alizarin red. We observed induction in the expression of CD36, cytokines, calcification markers, and ER stress markers under high glucose that was exacerbated by oxLDL. These results were confirmed in carotid plaques from subjects with diabetes versus non-diabetic subjects. Accordingly, the uptake of DiI-labeled oxLDL was increased after exposure to high glucose. The silencing of CD36 reduced the induction of CD36 and the expression of calcification enzymes and mineralization of VSMC. Our results indicate that CD36 signaling is partially involved in hyperglycemia and oxLDL-induced vascular calcification in diabetes.

Published
2020

23. Role of the Scavenger Receptor CD36 in Accelerated Diabetic Atherosclerosis

Author

Navas-Madroñal, Miquel, Castelblanco, Esmeralda, Camacho, Mercedes, Consegal, Marta, Ramírez-Morros, Anna, Sarrias, Maria-Rosa, Perez, Paulina, Alonso, Núria, Galán, María, Mauricio Puente, Dídac, Universitat Autònoma de Barcelona, Navas-Madroñal, Miquel, Castelblanco, Esmeralda, Camacho, Mercedes, Consegal, Marta, Ramírez-Morros, Anna, Sarrias, Maria-Rosa, Perez, Paulina, Alonso, Núria, Galán, María, Mauricio Puente, Dídac, and Universitat Autònoma de Barcelona

Abstract

Diabetes mellitus entails increased atherosclerotic burden and medial arterial calcification, but the precise mechanisms are not fully elucidated. We aimed to investigate the implication of CD36 in inflammation and calcification processes orchestrated by vascular smooth muscle cells (VSMCs) under hyperglycemic and atherogenic conditions. We examined the expression of CD36, pro-inflammatory cytokines, endoplasmic reticulum (ER) stress markers, and mineralization-regulating enzymes by RT-PCR in human VSMCs, cultured in a medium containing normal (5 mM) or high glucose (22 mM) for 72 h with or without oxidized low-density lipoprotein (oxLDL) (24 h). The uptake of 1,1'-dioctadecyl-3,3,3',3-tetramethylindocarbocyanine perchlorate-fluorescently (DiI) labeled oxLDL was quantified by flow cytometry and fluorimetry and calcification assays were performed in VSMC cultured in osteogenic medium and stained by alizarin red. We observed induction in the expression of CD36, cytokines, calcification markers, and ER stress markers under high glucose that was exacerbated by oxLDL. These results were confirmed in carotid plaques from subjects with diabetes versus non-diabetic subjects. Accordingly, the uptake of DiI-labeled oxLDL was increased after exposure to high glucose. The silencing of CD36 reduced the induction of CD36 and the expression of calcification enzymes and mineralization of VSMC. Our results indicate that CD36 signaling is partially involved in hyperglycemia and oxLDL-induced vascular calcification in diabetes.

Published
2020

24. Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes

Author

Castelblanco, Esmeralda, Betriu, Àngels, Hernández, Marta, Granado-Casas, Minerva, Ortega, Emilio, Soldevila, Berta, Ramírez-Morros, Anna, Franch-Nadal, Josep, Puig Domingo, Manuel, Fernández, Elvira, Avogaro, Angelo, Alonso, Núria, Mauricio Puente, Dídac, Castelblanco, Esmeralda, Betriu, Àngels, Hernández, Marta, Granado-Casas, Minerva, Ortega, Emilio, Soldevila, Berta, Ramírez-Morros, Anna, Franch-Nadal, Josep, Puig Domingo, Manuel, Fernández, Elvira, Avogaro, Angelo, Alonso, Núria, and Mauricio Puente, Dídac

Abstract

The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of plaque in a group of 340 subjects with and 304 without T1D, all of them without cardiovascular disease. One hundred and seven patients with T1D (49.5% women; age 54 ± 9.8 years) and 67 control subjects without diabetes who had at least one carotid plaque were included in the study. The proportion of subjects who had only echolucent plaques was reduced in the group of patients with T1D (48.6% vs. 73.1%). In contrast, the proportion with only echogenic (25.2% vs. 7.5%) and calcified plaques (9.4% vs. 1.5%) was increased compared with subjects without diabetes. Moreover, having at least one echogenic plaque was more frequent in T1D patients compared with subjects without diabetes (49.5% vs. 26.9% p = 0.005). In addition to diabetes (OR 2.28; p = 0.026), age (OR 1.06, p = 0.002) was the other variable associated with echogenic plaque existence in multiple regression analysis. Patients with T1D exhibit a differential pattern of carotid plaque type compared with subjects without diabetes, with an increased frequency of echogenic and extensively calcified plaques.

Published
2019

25. Assessment of Inner Retinal Layers and Choroidal Thickness in Type 1 Diabetes Mellitus: A Cross-Sectional Study

Author

Carbonell, Marc, primary, Alonso, Núria, additional, Castelblanco, Esmeralda, additional, Real, Jordi, additional, Ramírez-Morros, Anna, additional, Simó, Rafael, additional, Hernández, Cristina, additional, Jurjo, Carme, additional, Traveset, Alícia, additional, Valldeperas, Xavier, additional, and Mauricio, Dídac, additional

Published
2019
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26. Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes

Author

Castelblanco, Esmeralda, primary, Betriu, Àngels, additional, Hernández, Marta, additional, Granado-Casas, Minerva, additional, Ortega, Emilio, additional, Soldevila, Berta, additional, Ramírez-Morros, Anna, additional, Franch-Nadal, Josep, additional, Puig-Domingo, Manel, additional, Fernández, Elvira, additional, Avogaro, Angelo, additional, Alonso, Núria, additional, and Mauricio, Dídac, additional

Published
2019
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27. Poorer Quality of Life and Treatment Satisfaction is Associated with Diabetic Retinopathy in Patients with Type 1 Diabetes without Other Advanced Late Complications

Author

Granado-Casas, Minerva, primary, Castelblanco, Esmeralda, additional, Ramírez-Morros, Anna, additional, Martín, Mariona, additional, Alcubierre, Nuria, additional, Martínez-Alonso, Montserrat, additional, Valldeperas, Xavier, additional, Traveset, Alicia, additional, Rubinat, Esther, additional, Lucas-Martin, Ana, additional, Hernández, Marta, additional, Alonso, Núria, additional, and Mauricio, Didac, additional

Published
2019
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28. Type 1 Diabetic Subjects with Diabetic Retinopathy Show an Unfavorable Pattern of Fat Intake

Author

Granado-Casas, Minerva, Ramírez-Morros, Anna, Martín, Mariona, Real, Jordi, Alonso, Núria, Valldeperas, Xavier, Traveset, Alicia, Rubinat, Esther, Alcubierre, Nuria, Hernández, Marta, Puig Domingo, Manuel, Lecube, Albert, Castelblanco, Esmeralda, Mauricio Puente, Dídac, Universitat Autònoma de Barcelona, Granado-Casas, Minerva, Ramírez-Morros, Anna, Martín, Mariona, Real, Jordi, Alonso, Núria, Valldeperas, Xavier, Traveset, Alicia, Rubinat, Esther, Alcubierre, Nuria, Hernández, Marta, Puig Domingo, Manuel, Lecube, Albert, Castelblanco, Esmeralda, Mauricio Puente, Dídac, and Universitat Autònoma de Barcelona

Abstract

Medical nutrition therapy is an important part of the management of type 1 diabetes mellitus (T1DM). Proper adherence to a healthy diet may have a favorable impact on diabetes management and its diabetic complications. Our aim was to assess differences in food and nutrient intake of type 1 diabetic patients with and without diabetic retinopathy (DR). This was a two-center, cross-sectional study in patients with T1DM, with and without DR. Subjects were recruited from the outpatient clinic of the two participating centers. A validated food frequency questionnaire was administered. A total of 103 T1DM patients with DR and 140 T1DM patient without DR were recruited. Subjects with DR showed a lower intake of total fat (p = 0.036) than that of their non-DR counterparts. DR was associated with increasing age (p = 0.004), hypertension (p < 0.001), and diabetes duration (p < 0.001), however there was a negative association with high educational level (p = 0.018). The multivariate-adjusted analysis showed that the intake of complex carbohydrates was positively related to the presence of DR (p = 0.031). In contrast, the intakes of total fat (p = 0.009), monounsaturated fatty acids (MUFAs) (p = 0.012), oleic acid (p = 0.012), and vitamin E (p = 0.006) were associated with the absence of DR. As conclusions, the intake of total MUFAs, oleic acid, and vitamin E is associated with a lower frequency of DR in patients with T1DM. These results suggest a potential protective effect of these lipid components for DR.

Published
2018

29. Type 1 Diabetic Subjects with Diabetic Retinopathy Show an Unfavorable Pattern of Fat Intake

Author

Granado-Casas, Minerva, primary, Ramírez-Morros, Anna, additional, Martín, Mariona, additional, Real, Jordi, additional, Alonso, Núria, additional, Valldeperas, Xavier, additional, Traveset, Alicia, additional, Rubinat, Esther, additional, Alcubierre, Nuria, additional, Hernández, Marta, additional, Puig-Domingo, Manel, additional, Lecube, Albert, additional, Castelblanco, Esmeralda, additional, and Mauricio, Didac, additional

Published
2018
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30. Improved adherence to Mediterranean Diet in adults with type 1 diabetes mellitus

Author

Granado-Casas, Minerva, primary, Alcubierre, Nuria, additional, Martín, Mariona, additional, Real, Jordi, additional, Ramírez-Morros, Anna M., additional, Cuadrado, Maribel, additional, Alonso, Núria, additional, Falguera, Mireia, additional, Hernández, Marta, additional, Aguilera, Eva, additional, Lecube, Albert, additional, Castelblanco, Esmeralda, additional, Puig-Domingo, Manel, additional, and Mauricio, Dídac, additional

Published
2018
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31. Low-grade Inflammatory Marker Profile May Help to Differentiate Patients With LADA, Classic Adult-Onset Type 1 Diabetes, and Type 2 Diabetes

Author

Castelblanco, Esmeralda, primary, Hernández, Marta, additional, Castelblanco, Andrea, additional, Gratacòs, Mònica, additional, Esquerda, Aureli, additional, Molló, Àngels, additional, Ramírez-Morros, Anna, additional, Real, Jordi, additional, Franch-Nadal, Josep, additional, Fernández-Real, José-Manuel, additional, and Mauricio, Dídac, additional

Published
2018
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33. Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes

Author

Ramírez-Morros, Anna, primary, Granado-Casas, Minerva, additional, Alcubierre, Nuria, additional, Martinez-Alonso, Montserrat, additional, Real, Jordi, additional, Castelblanco, Esmeralda, additional, Esquerda, Aureli, additional, Cao, Gonzalo, additional, Rubinat, Esther, additional, Hernández, Marta, additional, Alonso, Núria, additional, Fernández, Elvira, additional, and Mauricio, Didac, additional

Published
2017
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34. High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

Author

Alemany, Andrea, Millat-Martinez, Pere, Corbacho-Monné, Marc, Malchair, Pierre, Ouchi, Dan, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodríguez Codina, Joana, Amado Simon, Rosa, Videla, Sebastian, Costes, Gèlia, Capdevila-Jáuregui, Mar, Torrano-Soler, Pamela, San José, Alba, Bonet Papell, Glòria, Puig, Jordi, Otero, Aurema, Ruibal Suarez, Jose Carlos, Zarauza Pellejero, Alvaro, Llopis Roca, Ferran, Rodriguez Cortez, Orlando, Garcia Garcia, Vanesa, Vidal-Alaball, Josep, Millan, Anna, Contreras, Enric, Grifols, Joan-Ramon, Ancochea, Àgueda, Galvan-Femenia, Ivan, Piccolo Ferreira, Francini, Bonet, Mireia, Cantoni, Jordi, Prat, Núria, Ara, Jordi, Forcada Arcarons, Anna, Farré, Magí, Pradenas, Edwards, Blanco, Julià, Àngel Rodriguez-Arias, Miquel, Fernández Rivas, Gema, Marks, Michael, Bassat, Quique, Blanco, Ignacio, Baro, Bàrbara, Clotet, Bonaventura, Mitjà, Oriol, Ferrer, Susana, Gallardo, Mireia, Ubals, Maria, González-Beiras, Camila, Vall-Mayans, Martí, Suñer, Clara, Laporte-Villar, Clàudia, Nieto, Aroa, Comas-Leon, Xavier, Jiménez, Zahida, Ramírez-Viaplana, Ferran, Delgado-Capel, Maria, Díez Sánchez, Beatriz, Pons Barber, Maria, Gonzalez Ruiz, Cristian, Navarrete Gonzalez, Laura, González García, David, Vivero Larraza, Ainhoa, Carceles Peiró, Victor, Roquer López, Clàudia, Robert, Neus, Palet, Carles, Gudiol, Carlota, Casares Gonzalez, Pablo, Arcos Vila, Gemma, Flores Aguilera, Begoña, Rodríguez-Sevilla, Graciela, Dastis Arias, Macarena, Roca Font, Judit, Carrasco Matos, Katherine M., Saüch Valmaña, Glòria, Vidal Obradors, Carla, Tarres García, Silvia, Curriu Sabatès, Margarida, Nieto Rodríguez, Raquel, Línio, Rosa, Fornos, Míriam, Casamitjana, Natàlia, Alonso, Eva, Martínez, Núria, Maglio, Laura Analía, Comellas Fernandez, Laura, Garcia, Nadia, Hernández, Luis, González, Maria Isabel, Bravo, Anna, García, Yolanda, Sauleda Oliveras, Silvia, Vertiz, Tatiana, Benavent, Sergio, Bianco, Andrea Sofia, Verdaguer, Joaquim, Briones Zambrano, Ney Nicanor, Viozquez Meya, Maria, Hernández, Águeda, Casaña Lopez, Cristina, Bordoy, Antoni E., González Soler, Victoria, Giménez, Montserrat, París, Alexa, Marfil, Silvia, Trinité, Benjamin, and Grau, Eulàlia

Abstract

Convalescent plasma has been proposed as an early treatment to interrupt the progression of early COVID-19 to severe disease, but there is little definitive evidence. We aimed to assess whether early treatment with convalescent plasma reduces the risk of hospitalisation and reduces SARS-CoV-2 viral load among outpatients with COVID-19.

Published
2024
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35. Mejorando la Calidad de Vida en Personas Mayores con el Síndrome del Declive: El Rol de la Terapia Ocupacional en Atención Primaria

Author

Arias, Gemma Riera, Corcoll, Judith Serra, Arnaus, Marina Casadevall, Vidal-Alaball, Josep, Ramírez-Morros, Anna, and Solé, Glòria Arnau

Abstract

Objetivos:Evaluar el efecto de una intervención de terapia ocupacional en usuarios diagnosticados recientemente de síndrome del declive, con una disminución en el índice de Barthel y/o Lawton en el último mes y susceptible de mejora según criterio clínico.

Published
2024
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36. Improving safety of autologous haematopoietic stem cell transplantation in patients with Crohn's disease

Author

Jauregui-Amezaga, Aranzazu, primary, Rovira, Montserrat, additional, Marín, Pedro, additional, Salas, Azucena, additional, Pinó-Donnay, Susana, additional, Feu, Faust, additional, Elizalde, J Ignasi, additional, Fernández-Avilés, Francesc, additional, Martínez, Carmen, additional, Gutiérrez, Gonzalo, additional, Rosiñol, Laura, additional, Carreras, Enric, additional, Urbano, Alvaro, additional, Lozano, Miguel, additional, Cid, Joan, additional, Suárez-Lledó, María, additional, Mensa, Josep, additional, Rimola, Jordi, additional, Rodríguez, Sonia, additional, Masamunt, Mari Carme, additional, Comas, Dolors, additional, Ruíz, Irene, additional, Ramírez-Morros, Anna, additional, Gallego, Marta, additional, Ordás, Ingrid, additional, Panés, Julian, additional, and Ricart, Elena, additional

Published
2015
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37. Intraperitoneal Administration of Autologous Tolerogenic Dendritic Cells for Refractory Crohn’s Disease: A Phase I Study

Author

Jauregui-Amezaga, Aranzazu, primary, Cabezón, Raquel, additional, Ramírez-Morros, Anna, additional, España, Carolina, additional, Rimola, Jordi, additional, Bru, Concepció, additional, Pinó-Donnay, Susana, additional, Gallego, Marta, additional, Masamunt, Maria Carme, additional, Ordás, Ingrid, additional, Lozano, Miguel, additional, Cid, Joan, additional, Panés, Julian, additional, Benítez-Ribas, Daniel, additional, and Ricart, Elena, additional

Published
2015
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38. Corrigendum: Characterization of Inflammation and Fibrosis in Crohn’s Disease Lesions by Magnetic Resonance Imaging

Author

Rimola, Jordi, primary, Planell, Núria, additional, Rodríguez, Sonia, additional, Delgado, Salvadora, additional, Ordás, Ingrid, additional, Ramírez-Morros, Anna, additional, Ayuso, Carmen, additional, Aceituno, Montse, additional, Ricart, Elena, additional, Jauregui-Amezaga, Aranzazu, additional, Panés, Julián, additional, and Cuatrecasas, Míriam, additional

Published
2015
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39. Characterization of Inflammation and Fibrosis in Crohn’s Disease Lesions by Magnetic Resonance Imaging

Author

Rimola, Jordi, primary, Planell, Núria, additional, Rodríguez, Sonia, additional, Delgado, Salvadora, additional, Ordás, Ingrid, additional, Ramírez-Morros, Anna, additional, Ayuso, Carmen, additional, Aceituno, Montse, additional, Ricart, Elena, additional, Jauregui-Amezaga, Aranzazu, additional, Panés, Julián, additional, and Cuatrecasas, Míriam, additional

Published
2015
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40. Accuracy of Magnetic Resonance Enterography in Assessing Response to Therapy and Mucosal Healing in Patients With Crohn's Disease

Author

Ordás, Ingrid, primary, Rimola, Jordi, additional, Rodríguez, Sonia, additional, Paredes, José M., additional, Martínez-Pérez, María J., additional, Blanc, Esther, additional, Arévalo, Juan A., additional, Aduna, Marta, additional, Andreu, Montserrat, additional, Radosevic, Alexander, additional, Ramírez-Morros, Anna M., additional, Pinó, Susana, additional, Gallego, Marta, additional, Jauregui-Amezaga, Aranzazu, additional, Ricart, Elena, additional, and Panés, Julián, additional

Published
2014
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41. Type 1 Diabetic Subjects with Diabetic Retinopathy Show an Unfavorable Pattern of Fat Intake.

Author

Ramírez-Morros, Anna, Granado-Casas, Minerva, Alonso, Núria, Puig-Domingo, Manel, Castelblanco, Esmeralda, Alcubierre, Nuria, Hernández, Marta, Lecube, Albert, Mauricio, Didac, Traveset, Alicia, Martín, Mariona, Real, Jordi, Rubinat, Esther, and Valldeperas, Xavier

Abstract

Medical nutrition therapy is an important part of the management of type 1 diabetes mellitus (T1DM). Proper adherence to a healthy diet may have a favorable impact on diabetes management and its diabetic complications. Our aim was to assess differences in food and nutrient intake of type 1 diabetic patients with and without diabetic retinopathy (DR). This was a two-center, cross-sectional study in patients with T1DM, with and without DR. Subjects were recruited from the outpatient clinic of the two participating centers. A validated food frequency questionnaire was administered. A total of 103 T1DM patients with DR and 140 T1DM patient without DR were recruited. Subjects with DR showed a lower intake of total fat (p = 0.036) than that of their non-DR counterparts. DR was associated with increasing age (p = 0.004), hypertension (p < 0.001), and diabetes duration (p < 0.001), however there was a negative association with high educational level (p = 0.018). The multivariate-adjusted analysis showed that the intake of complex carbohydrates was positively related to the presence of DR (p = 0.031). In contrast, the intakes of total fat (p = 0.009), monounsaturated fatty acids (MUFAs) (p = 0.012), oleic acid (p = 0.012), and vitamin E (p = 0.006) were associated with the absence of DR. As conclusions, the intake of total MUFAs, oleic acid, and vitamin E is associated with a lower frequency of DR in patients with T1DM. These results suggest a potential protective effect of these lipid components for DR. [ABSTRACT FROM AUTHOR]

Published
2018
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42. [Improving quality of life in older adults with the decline syndrome: The role of occupational therapy in primary care].

Author

Riera Arias G, Serra Corcoll J, Casadevall Arnaus M, Vidal-Alaball J, Ramírez-Morros A, and Arnau Solé G

Subjects
Humans, Female, Male, Aged, Longitudinal Studies, Activities of Daily Living, Syndrome, Aged, 80 and over, Occupational Therapy methods, Primary Health Care, Quality of Life
Abstract

Objective: To evaluate the effect of an occupational therapy intervention in users recently diagnosed with the decline syndrome, who have experienced a decrease in the Barthel and/or Lawton index in the last month and susceptible to improvement based on medical opinion., Design: Non-controlled, quasi-experimental longitudinal study. A pre-post intervention., Location: Sant Hipòlit de Voltregà health centre. Osona, Barcelona., Participants: Patients referred by the centre's primary care nursing, social work or medical staff with a recent diagnosis of decline syndrome who may benefit from the intervention of an occupational therapy professional., Intervention: Following the initial assessment visit, four training sessions were conducted to improve functional independence, mobility and adaptation of the home environment, providing training to primary caregivers., Main Measurements: Patient autonomy was assessed using the Barthel and Lawton scales, quality of life using the EuroQol questionnaire (EQ-5D) and home suitability using the home suitability assessment questionnaire., Results: Improvements were observed in autonomy in activities of daily living (p=0.003), mobility (p=0.001) and housing adaptation (p<0.001). The level of anxiety/depression was reduced (p=0.028), and the mean health status score increased markedly (p<0.001)., Conclusions: This study highlights the improvement in the quality of life and autonomy in the basic activities of daily living for individuals receiving occupational therapy, emphasizing the need for home adaptation and family support., (Copyright © 2024 The Author(s). Publicado por Elsevier España S.L.U. All rights reserved.)

Published
2024
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43. Improving safety of autologous haematopoietic stem cell transplantation in patients with Crohn's disease.

Author

Jauregui-Amezaga A, Rovira M, Marín P, Salas A, Pinó-Donnay S, Feu F, Elizalde JI, Fernández-Avilés F, Martínez C, Gutiérrez G, Rosiñol L, Carreras E, Urbano A, Lozano M, Cid J, Suárez-Lledó M, Mensa J, Rimola J, Rodríguez S, Masamunt MC, Comas D, Ruíz I, Ramírez-Morros A, Gallego M, Ordás I, Panés J, and Ricart E

Subjects
Adolescent, Adult, Female, Humans, Male, Monitoring, Physiologic methods, Patient Acuity, Platelet Count methods, Prospective Studies, Remission Induction methods, Severity of Illness Index, Treatment Outcome, Antibiotic Prophylaxis methods, Crohn Disease blood, Crohn Disease diagnosis, Crohn Disease psychology, Crohn Disease therapy, Hematopoietic Stem Cell Transplantation adverse effects, Hematopoietic Stem Cell Transplantation methods, Postoperative Complications diagnosis, Postoperative Complications prevention & control, Quality of Life, Transplantation Conditioning methods
Abstract

Objective: To evaluate the feasibility and toxicity of autologous haematopoietic stem cell transplantation (HSCT) for the treatment of refractory Crohn's disease (CD)., Design: In this prospective study, patients with refractory CD suffering an aggressive disease course despite medical treatment, impaired quality of life and in whom surgery was not an acceptable option underwent HSCT. Toxicity and complications during the procedure and within the first year following transplantation were evaluated, along with the impact of the introduction of supportive measures on safety outcomes., Results: 26 patients were enrolled. During mobilisation, 16 patients (62%) presented febrile neutropaenia, including one bacteraemia and two septic shocks. Neutropaenia median time after mobilisation was 5 days. 5 patients withdrew from the study after mobilisation and 21 patients entered the conditioning phase. Haematopoietic recovery median time for neutrophils (>0.5×10(9)/L) was 11 days and for platelets (>20×10(9)/L) 4 days. Twenty patients (95%) suffered febrile neutropaenia and three patients (27%) presented worsening of the perianal CD activity during conditioning. Among non-infectious complications, 6 patients (28.5%) presented antithymocyte globulin reaction, 12 patients (57%) developed mucositis and 2 patients (9.5%) had haemorrhagic complications. Changes in supportive measures over the study, particularly antibiotic prophylaxis regimes during mobilisation and conditioning, markedly diminished the incidence of severe complications. During the first 12-month follow-up, viral infections were the most commonly observed complications, and one patient died due to systemic cytomegalovirus infection., Conclusions: Autologous HSCT for patients with refractory CD is feasible, but extraordinary supportive measures need to be implemented. We suggest that this procedure should only be performed in highly experienced centres., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/)

Published
2016
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