1. Antimicrobial properties of triazolato terpyridine Pd(II) and Pt(II) complexes formed by [3+2] cycloaddition coupling reaction.
- Author
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Mansour, Ahmed M., Radacki, Krzysztof, Mostafa, Gamal A.E., Ali, Essam A., and Shehab, Ola R.
- Subjects
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RING formation (Chemistry) , *LYSOZYMES , *ERYTHROCYTES , *CRYPTOCOCCUS neoformans , *DRUG development , *ETHYL esters , *CANDIDA albicans , *CYTOTOXINS - Abstract
[Display omitted] • The triazolate Pd(II) complex binds to lysozyme via the loss of triazolato ligand. • Agreement between the experimental and theoretical studies regarding the high stability of N2 triazolate complex over the N1 and N3 analogues. • Triazolate complexes exhibited comparable selective antifungal activity to reference drug. • The complexes are safe to normal cell line and are compatible with the red blood cells. Modern classes of antimicrobials are crucial because most drugs in development today are basically antibiotic derivatives. Even though a large number of metal-based compounds have been studied as antimicrobial agents, relatively few studies have examined the antimicrobial properties of Pd(II) and Pt(II) compounds. The [3+2] cycloaddition reactions of [M(N 3)L]PF 6 (M = Pd(II) and Pt(II); L = 4′-(2-pyridyl)-2,2′:6′,2″-terpyridine) with 4,4,4-trifluoro-2-butynoic acid ethyl ester gave the corresponding triazolate complexes. The reaction products were fully characterized with a variety of analytical and spectroscopic tools including X-ray crystallographic analysis. The crystal structure of [Pd(triazolatoCF3,COOCH2CH3)L]PF 6 provided cut-off evidence that the kinetically formed N1-triazolato isomer favoured the isomerization to the thermodynamically stable N2-analogue. The experimental work was complemented with computational work to get an insight into the nature of the predominant triazolate isomer. The lysozyme binding affinity of the triazolate complexes was examined by mass spectrometry. An analysis of the lysozyme Pd(II) adducts suggests a coordinative covalent mode of binding via the loss of the triazolato ligand. The free ligand and its triazolate complexes displayed selective toxicity against Candida albicans and Cryptococcus neoformans , while no cytotoxicity was observed against the normal human embryonic kidney cell line. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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