1. Electrophysiological predictors of early response to antidepressants in major depressive disorder.
- Author
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Tang H, Xia Y, Hua L, Dai Z, Wang X, Yao Z, and Lu Q
- Subjects
- Humans, Male, Female, Adult, Middle Aged, Psychomotor Performance drug effects, Psychomotor Performance physiology, Treatment Outcome, Psychomotor Disorders physiopathology, Psychomotor Disorders drug therapy, Case-Control Studies, Depressive Disorder, Major drug therapy, Depressive Disorder, Major physiopathology, Antidepressive Agents therapeutic use, Antidepressive Agents pharmacology, Magnetoencephalography
- Abstract
Background: Psychomotor retardation (PMR) is a core feature of major depressive disorder (MDD), which is characterized by abnormalities in motor control and cognitive processes. PMR in MDD can predict a poor antidepressant response, suggesting that PMR may serve as a marker of the antidepressant response. However, the neuropathological relationship between treatment outcomes and PMR remains uncertain. Thus, this study examined electrophysiological biomarkers associated with poor antidepressant response in MDD., Methods: A total of 142 subjects were enrolled in this study, including 49 healthy controls (HCs) and 93 MDD patients. All participants performed a simple right-hand visuomotor task during magnetoencephalography (MEG) scanning. Patients who exhibited at least a 50 % reduction in disorder severity at the endpoint (>2 weeks) were considered to be responders. Motor-related beta desynchronization (MRBD) and inter- and intra-hemispheric functional connectivity were measured in the bilateral motor network., Results: An increased MRBD and decreased inter- and intra-hemispheric functional connectivity in the motor network during movement were observed in non-responders, relative to responders and HCs. This dysregulation predicted the potential antidepressant response., Conclusion: Abnormal local activity and functional connectivity in the motor network indicate poor psychomotor function, which might cause insensitivity to antidepressant treatment. This could be regarded as a potential neural mechanism for the prediction of a patient's treatment response., Competing Interests: Declaration of competing interest The authors have no conflict of interest to declare., (Copyright © 2024. Published by Elsevier B.V.)
- Published
- 2024
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