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The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women.
- Source :
-
European journal of endocrinology [Eur J Endocrinol] 2018 Aug; Vol. 179 (2), pp. 73-84. Date of Electronic Publication: 2018 May 22. - Publication Year :
- 2018
-
Abstract
- Objective: Human aging is accompanied by a decrease in growth hormone secretion and serum insulin-like growth factor (IGF)-1 levels. Also, loss of muscle mass and strength and impairment of physical performance, ending in a state of frailty, are seen in elderly. We aimed to investigate whether handgrip strength, physical performance and recurrent falls are related to serum IGF-1 levels in community-dwelling elderly.<br />Design: Observational cohort study (cross-sectional and prospective).<br />Methods: We studied the association between IGF-1 and handgrip strength, physical performance and falls in participants of the Longitudinal Aging Study Amsterdam. A total of 1292 participants were included (633 men, 659 women). Serum IGF-1 levels were divided into quartiles (IGF-1-Q1 to IGF-1-Q4). Data on falls were collected prospectively for a period of 3 years. All analyses were stratified for age and physical activity and adjusted for relevant confounders.<br />Results: Men with a low physical activity score in IGF-1-Q1 and IGF-1-Q2 of the younger age group had a lower handgrip strength compared to IGF-1-Q4. In younger more active males in IGF-1-Q2 physical performance was worse. Recurrent fallers were less prevalent in older, low active males with low IGF-1 levels. In females, recurrent fallers were more prevalent in older, more active females in IGF-1-Q2. IGF-1 quartile may predict changes in handgrip strength and physical performance in men and women.<br />Conclusions: Our results indicate that lower IGF-1 levels are associated with lower handgrip strength and worse physical performance, but less recurrent fallers especially in men. Associations were often more robust in IGF-1-Q2. Future studies on this topic are desirable.<br /> (© 2018 European Society of Endocrinology.)
- Subjects :
- Aged
Aged, 80 and over
Cohort Studies
Cross-Sectional Studies
Female
Hand Strength
Humans
Insulin-Like Growth Factor I metabolism
Longitudinal Studies
Male
Middle Aged
Netherlands epidemiology
Prospective Studies
Psychomotor Disorders blood
Psychomotor Disorders epidemiology
Psychomotor Disorders physiopathology
Psychomotor Performance
Risk
Sarcopenia blood
Sarcopenia epidemiology
Sarcopenia physiopathology
Sarcopenia prevention & control
Sex Factors
Accidental Falls prevention & control
Aging
Exercise
Healthy Lifestyle
Insulin-Like Growth Factor I analysis
Patient Compliance
Psychomotor Disorders prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1479-683X
- Volume :
- 179
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 29789408
- Full Text :
- https://doi.org/10.1530/EJE-18-0076