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125 results on '"Petersen, J. W."'

2. Characterizing left ventricular stiffness in women with signs and symptoms of ischemia with no obstructive coronary arteries

Author

Wei, J, primary, Samuels, B, additional, Oneglia, A, additional, Tjoe, B, additional, Gomez, J M D, additional, Manchanda, A S, additional, Samuel, T J, additional, Azarbal, B, additional, Kwan, A C, additional, Anderson, R D, additional, Petersen, J W, additional, Berman, D S, additional, Pepine, C J, additional, Bairey Merz, C N, additional, and Nelson, M D, additional

Published
2022
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22. Identification of murine T-cell epitopes on the S4 subunit of pertussis toxin

Author

Petersen, J W, Holm, A, Ibsen, P H, Hasløv, K, and Heron, I

Subjects
T-Lymphocytes, Vaccination, Immunology, Mice, Inbred Strains, In Vitro Techniques, Lymphocyte Activation, Microbiology, Peptide Fragments, Epitopes, Mice, Infectious Diseases, Pertussis Toxin, Animals, Parasitology, Virulence Factors, Bordetella, Research Article
Abstract

The aim of the present study was to identify murine T-cell epitopes on pertussis toxin subunit S4. Six mouse strains with five different haplotypes at the H-2 locus were immunized with the pertussis toxin B oligomer. Lymph node lymphocytes were isolated and stimulated in an in vitro proliferation assay with pertussis toxin components and 11 overlapping synthetic peptides synthesized on the basis of the primary sequence of S4. In vitro proliferative responses to the synthetic peptides revealed the presence of four distinct murine T-cell epitopes on subunit S4. The recognition of the peptides was major histocompatibility complex restricted. Immunizing four of the six mouse strains with the synthetic peptides showed that the peptides which were demonstrated to contain T-cell epitopes following immunization with the B oligomer were able to induce proliferative responses to detoxified pertussis toxin and pertussis toxin components containing subunit S4. One of the identified murine T-cell epitopes corresponded to one of the major human T-cell epitopes previously identified on subunit S4. It is hoped that this murine model system will facilitate the development of a synthetic immunogen mimicking the protective properties of pertussis toxin.

Published
1993
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40. Mössbauer study of119Sn defects in silicon from ion implantations of radioactive119In

Author

Weyer, G., Damgaard, S., Petersen, J. W., and Heinemeier, J.

Abstract

Radioactive119In+ ions (T1/2=2.1 min) obtained from the ISOLDE facility at CERN have been implanted into silicon single crystals at room temperature. Mössbauer emission spectra from the 24 keV ?-radiation of the daughter119Sn have been measured by fast resonance-counting technique. Five independent lines, characterized by their hyperfine parameters and Debye temperatures, have been found in the spectra. From the bonding configurations, deduced for the Sn impurity atoms, these are concluded to be located in four different defects in the silicon lattice. Simple models are proposed for the defects.

Published
1979
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41. 119Sn Mössbauer study of the implantation behaviour of119In,119Sn,119mSn,119Sb and119mTe ions in SiC

Author

Petersen, J. W., Weyer, G., Nielsen, H. Loft, Damgaard, S., Choyke, W. J., and Andreasen, H.

Abstract

The implantation behaviour of stable119Sn+ ions and radioactive119In+,119mSn+,119Sb+ and119mTe+ ions in SiC has been investigated by, respectively, conversion-electron Mössbauer spectroscopy on the 24 keV transition of119Sn, and by Mössbauer emission spectroscopy on the 24 keVγ radiation emitted by the119Sn daughter after the decays of the radioactive isotopes. The Mössbauer spectra could be decomposed in most cases into two groups of lines, one originating from119Sn atoms on substitutional Si sites, the other from various Sn-vacancy complexes distinguished by their Mössbauer parameters. Annealing experiments reveal a strong dependence of the structure of the defects and the formation and annealing kinetics on the chemical nature of the impurities. Defects formed in 297 K implantations with119mSn and119Sb anneal above 500 ‡C, resulting in a preferential location of the impurities on substitutional Si sites, whereas119mTe atoms are efficient defect-trapping centres and no stable, substitutional fraction is observed on either lattice site. Possible structures for the Sn-vacancy complexes are discussed and comparison is made to similar defect complexes in group IV and in III–V semiconductors.

Published
1985
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50. AN AGGREGATE BASE STOCKAGE POLICY FOR RECOVER ABLE SPARE PARTS

Author

RAND CORP SANTA MONICA CA, Feeney, G. J., Petersen, J. W., Sherbrooke, C. C., RAND CORP SANTA MONICA CA, Feeney, G. J., Petersen, J. W., and Sherbrooke, C. C.

Abstract

This memorandum describes the initial results of a digital computer program that considers repair characteristics and unit cost by item in the computation of item stock levels. These levels will achieve a specified aggregate base fill rate across all recoverable items with the least dollar investment in base recoverable inventory. The test consisted of taking demand data for a sample of 2802 recoverable items at Andrews Air Force Base and using the first six months of data as model input to compute item stock levels required to achieve a range of aggregate base fill rates. Demands for these items for the next six months were then compared with these stock levels. It was found that the actual fill rates differed by less than 5 percent from the target fill rates that had been used in setting the stock levels. The most important result of the present study is the method which uses both repair characteristics and unit cost to analyze stock requirements across a large group of items., Report on Proj. RAND.

Published
1963

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