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4. Implementing co-created citizen science in five environmental epidemiological studies in the CitieS-Health project

Author

Planetary Health & Exposoom, Cancer, Circulatory Health, Froeling, Frederique, Gignac, Florence, Toran, Raul, Ortiz, Rodney, Ficorilli, Antonella, De Marchi, Bruna, Biggeri, Annibale, Kocman, David, Ftičar, Jure, Tratnik, Janja Snoj, Andrusaityte, Sandra, Grazuleviciene, Regina, Errandonea, Lucía, Vermeulen, Roel, Hoek, Gerard, Basagaña, Xavier, Planetary Health & Exposoom, Cancer, Circulatory Health, Froeling, Frederique, Gignac, Florence, Toran, Raul, Ortiz, Rodney, Ficorilli, Antonella, De Marchi, Bruna, Biggeri, Annibale, Kocman, David, Ftičar, Jure, Tratnik, Janja Snoj, Andrusaityte, Sandra, Grazuleviciene, Regina, Errandonea, Lucía, Vermeulen, Roel, Hoek, Gerard, and Basagaña, Xavier

Published
2024

5. Implementing co-created citizen science in five environmental epidemiological studies in the CitieS-Health project

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Froeling, Frederique, Gignac, Florence, Toran, Raul, Ortiz, Rodney, Ficorilli, Antonella, De Marchi, Bruna, Biggeri, Annibale, Kocman, David, Ftičar, Jure, Tratnik, Janja Snoj, Andrusaityte, Sandra, Grazuleviciene, Regina, Errandonea, Lucía, Vermeulen, Roel, Hoek, Gerard, Basagaña, Xavier, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Froeling, Frederique, Gignac, Florence, Toran, Raul, Ortiz, Rodney, Ficorilli, Antonella, De Marchi, Bruna, Biggeri, Annibale, Kocman, David, Ftičar, Jure, Tratnik, Janja Snoj, Andrusaityte, Sandra, Grazuleviciene, Regina, Errandonea, Lucía, Vermeulen, Roel, Hoek, Gerard, and Basagaña, Xavier

Published
2024

6. Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)

Author

Thierry-Chef Isabelle, Timmermann Beate, Journy Neige, Bernier Marie-Odile, McNally Richard, Dabin Jérémie, Brualla Lorenzo, Haghdoost Siamak, Sarukhan Adelaida, Haustermans Karin, De Wit Inge, Isebaert Sofie, Lassen-Ramshad Yasmin, Tram Henriksen Louise, Høyer Morten, Toussaint Laura, Boissonnat Guillaume, Thariat Juliette, Demoor-Goldschmidt Charlotte, Haddy Nadia, Bolle Stéphanie, Fresneau Brice, Belhout Amel, Dreger Steffen, Zeeb Hajo, Grazia Andreassi Maria, Campolo Jonica, Picano Eugenio, Jahnen Andreas, Ronckers Cécile, Maduro John H., Kjaerheim Kristina, Døhlen Gaute, Robsahm Trude Eid, Olerud Hilde M., Thevathas Utheya Salini, Afroz Susmita, Helge Østerås Bjørn, Schneider Uwe, Walsh Linda, Dumas Agnès, Jackson Angéla, Rage Estelle, De Saint-Hubert Marijke, Hardy Richard, Bäumer Christian, Steinmeier Theresa, Botzenhardt Suzan, Wette Martina, Ortiz Rodney, and Chumak Vadim

Subjects
Nuclear engineering. Atomic power, TK9001-9401
Abstract

The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.

Published
2023
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7. Advancing tools for human early lifecourse exposome research and translation (ATHLETE): Project overview

Author

Vrijheid, Martine, Basagaña, Xavier, Gonzalez, Juan R., Jaddoe, Vincent W. V., Jensen, Genon, Keun, Hector C., McEachan, Rosemary R. C., Porcel, Joana, Siroux, Valerie, Swertz, Morris A., Thomsen, Cathrine, Aasvang, Gunn Marit, Andrušaitytė, Sandra, Angeli, Karine, Avraam, Demetris, Ballester, Ferran, Burton, Paul, Bustamante, Mariona, Casas, Maribel, Chatzi, Leda, Chevrier, Cécile, Cingotti, Natacha, Conti, David, Crépet, Amélie, Dadvand, Payam, Duijts, Liesbeth, van Enckevort, Esther, Esplugues, Ana, Fossati, Serena, Garlantezec, Ronan, Gómez Roig, María Dolores, Grazuleviciene, Regina, Gützkow, Kristine B., Guxens, Mònica, Haakma, Sido, Hessel, Ellen V. S., Hoyles, Lesley, Hyde, Eleanor, Klanova, Jana, van Klaveren, Jacob D., Kortenkamp, Andreas, Le Brusquet, Laurent, Leenen, Ivonne, Lertxundi, Aitana, Lertxundi, Nerea, Lionis, Christos, Llop, Sabrina, Lopez-Espinosa, Maria-Jose, Lyon-Caen, Sarah, Maitre, Lea, Mason, Dan, Mathy, Sandrine, Mazarico, Edurne, Nawrot, Tim, Nieuwenhuijsen, Mark, Ortiz, Rodney, Pedersen, Marie, Perelló, Josep, Pérez-Cruz, Míriam, Philippat, Claire, Piler, Pavel, Pizzi, Costanza, Quentin, Joane, Richiardi, Lorenzo, Rodriguez, Adrian, Roumeliotaki, Theano, Sabin Capote, José Manuel, Santiago, Leonardo, Santos, Susana, Siskos, Alexandros P., Strandberg-Larsen, Katrine, Stratakis, Nikos, Sunyer, Jordi, Tenenhaus, Arthur, Vafeiadi, Marina, Wilson, Rebecca C., Wright, John, Yang, Tiffany, and Slama, Remy

Published
2021
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9. Project overview

Author

Vrijheid, Martine, Basagaña, Xavier, Gonzalez, Juan, Jaddoe, Vincent W. V., Jensen, Genon, Keun, Hector C., McEachan, Rosemary R. C., Porcel, Joana, Siroux, Valerie, Swertz, Morris A., Thomsen, Cathrine, Aasvang, Gunn Marit, Andrušaitytėm, Sandra, Angeli, Karine, Avraam, Demetris, Ballester, Ferran, Burton, Paul, Bustamante, Mariona, Casas, Maribel, Chatzi, Leda, Chevrier, Cécile, Cingotti, Natacha, Conti, David, Crépetn, Amélie, Dadvand, Payam, Duijts, Liesbeth, van Enckevort, Esther, Esplugues, Ana, Fossati, Serena, Garlantezec, Ronan, Gómez Roigu, María Dolores, Grazuleviciene, Regina, Gützkow, Kristine B., Guxens, Mònica, Haakma, Sido, Hessel, Ellen V. S., Hoyles, Lesley, Hyde, Eleanor, Klanova, Jana, van Klaveren, Jacob D., Kortenkamp, Andreas, Le Brusquet, Laurent, Leenen, Ivonne, Lertxundi, Aitana, Lertxundi, Nerea, Lionis, Christos, Llop, Sabrina, Lopez-Espinosa, Maria-Jose, Lyon-Caen, Sarah, Maitre, Lea, Mason, Dan, Mathy, Sandrine, Mazarico, Edurne, Nawrot, Tim, Nieuwenhuijsen, Mark, Ortiz, Rodney, Pedersen, Marie, Perelló, Josep, Pérez-Cruz, Míriam, Philippat, Claire, Piler, Pavel, Pizzi, Costanza, Quentin, Joane, Richiardi, Lorenzo, Rodriguez, Adrian, Roumeliotaki, Theano, Capote, José Manuel Sabin, Santiago, Leonardo, Santos, Susana, Siskos, Alexandros, Strandberg-Larsen, Katrine, Stratakis, Nikos, Sunyer, Jordi, Tenenhaus, Arthur, Vafeiadi, Marina, Wilson, Rebecca C., Wright, John, Yang, Tiffany, Slama, Remy, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), The Generation R Study Group, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Health & Environment Alliance, Imperial College London, Bradford Institute for Health Research Bradford, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), University Medical Center Groningen [Groningen] (UMCG), Norwegian Institute of Public Health [Oslo] (NIPH), Vytautas Magnus University - Vytauto Didziojo Universitetas (VDU), Direction de l'Evaluation des Risques (DER), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Newcastle University [Newcastle], Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne] (FISABIO), CIBER de Epidemiología y Salud Pública (CIBERESP), University of Southern California (USC), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Universitat de València (UV), École des Hautes Études en Santé Publique [EHESP] (EHESP), CHU Pontchaillou [Rennes], Institut de Recerca Pediàtrica Hospital Sant Joan de Déu [Barcelona, Spain], National Institute for Public Health and the Environment [Bilthoven] (RIVM), Nottingham Trent University, Research Centre for Toxic Compounds in the Environment [Brno] (RECETOX / MUNI), Faculty of Science [Brno] (SCI / MUNI), Masaryk University [Brno] (MUNI)-Masaryk University [Brno] (MUNI), Brunel University London [Uxbridge], Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of the Basque Country [Bizkaia] (UPV/EHU), Biodonostia Health Research Institute [Donostia-San Sebastian, Spain] (IIS Biodonostia), University of Crete [Heraklion] (UOC), Universitat Jaume I, Laboratoire d'Economie Appliquée de Grenoble (GAEL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Hasselt University (UHasselt), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), University of Copenhagen = Københavns Universitet (KU), Bettair Cities SL, Barcelona, Masaryk University [Brno] (MUNI), Department of Oncology [University of Turin], University of Turin, Erasmus University Rotterdam, IT University of Copenhagen, Laboratoire des signaux et systèmes (L2S), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of Liverpool, This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement number 874583—the Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project. This publication reflects only the authors’ view and the European Commission is not responsible for any use that may be made of the information it contains., Dr. Dadvand is funded by a Ramón y Cajal fellowship (RYC-2012-10995) awarded by the Spanish Ministry of Economy and Finance. Drs. Casas and Guxens are funded by the Instituto de Salud Carlos III (MS16/00128, CPII18/00018). Drs. Chatzi and Conti were supported by the National Institute of Environmental Health Sciences (R21ES029681, R01ES029944, R01ES030364, R01ES030691, and P30ES007048). Additional funding from National Institutes of Health supported Dr. Conti (P01CA196569, R01CA140561) and Dr. Stratakis (P30DK048522). Investigators Drs. McEachan and Wright receive funding from the National Institute for Health Research under its Applied Research Collaboration Yorkshire and Humber. Dr. Jaddoe received funding from a Consolidator Grant from the European Research Council (ERC-2014-CoG-648916). Dr. Duijts received funding from the European Union’s Horizon 2020 co-funded programme European Research Area Net on Biomarkers for Nutrition and Health (European Research Area Healthy Diet for a Healthy Life) (Early life programming of childhood health project [number 696295, 2017], ZonMW, The Netherlands [number 529051014, 2017]). Dr. Guxens received funding from the Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (EST-18 RF-25)., European Project: 874583,H2020,H2020-EU.3.1.2.,ATHLETE(2020), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Health & Environment Alliance (HEAL), Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK (BIHR), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), BIODonostia Research Institute, University of Copenhagen = Københavns Universitet (UCPH), Università degli studi di Torino = University of Turin (UNITO), IT University of Copenhagen (ITU), Pediatrics, Mathy, Sandrine, Advancing Tools for Human Early Lifecourse Exposome Research and Translation - ATHLETE - - H20202020-01-01 - 2024-12-31 - 874583 - VALID, Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Basagana, Xavier/0000-0002-8457-1489, Stratakis, Nikos/0000-0003-4613-0989, Yang, Tiffany/0000-0003-4549-7850, Andrusaityte, Sandra/0000-0002-4309-0208, McEachan, Rosemary/0000-0003-1302-6675, Hoyles, Lesley/0000-0002-6418-342X, LERTXUNDI MANTEROLA, AITANA/0000-0002-9421-6237, Lopez-Espinosa, Maria-Jose/0000-0003-1202-8740, Santos, Susana/0000-0003-0613-3181, Nawrot, Tim/0000-0002-3583-3593, and Wilson, Becca/0000-0003-2294-593X

Subjects
PARENTAL SMOKING, exposure assessment, [SDV]Life Sciences [q-bio], ENDOCRINE-DISRUPTING CHEMICALS, Adolescent health, Environmental Sciences & Ecology, exposome, Child health, Early life, Exposome, Exposure assessment, SDG 3 - Good Health and Well-being, early life, LIFE-COURSE APPROACH, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, Public, Environmental & Occupational Health, Science & Technology, BIRTH COHORT, adolescent health, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, AMBIENT AIR-POLLUTION, [SDV] Life Sciences [q-bio], GREEN SPACES, COGNITIVE-DEVELOPMENT, COHORT PROFILE, child health, Life Sciences & Biomedicine, SOCIOECONOMIC POSITION, Environmental Sciences, PREGNANT-WOMEN
Abstract

Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policy-makers, and other stakeholders, beyond the duration of the project. ATHLETE'S results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement number 874583—the Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project. This publication reflects only the authors’ view and the European Commission is not responsible for any use that may be made of the information it contains. Dr. Dadvand is funded by a Ramón y Cajal fellowship (RYC2012-10995) awarded by the Spanish Ministry of Economy and Finance. Drs. Casas and Guxens are funded by the Instituto de Salud Carlos III (MS16/00128, CPII18/00018). Drs. Chatzi and Conti were supported by the National Institute of Environmental Health Sciences (R21ES029681, R01ES029944, R01ES030364, R01ES030691, and P30ES007048). Additional funding from National Institutes of Health supported Dr. Conti (P01CA196569, R01CA140561) and Dr. Stratakis (P30DK048522). Investigators Drs. McEachan and Wright receive funding from the National Institute for Health Research under its Applied Research Collaboration Yorkshire and Humber. Dr. Jaddoe received funding from a Consolidator Grant from the European Research Council (ERC-2014-CoG-648916). Dr. Duijts received funding from the European Union’s Horizon 2020 co-funded programme European Research Area Net on Biomarkers for Nutrition and Health (European Research Area Healthy Diet for a Healthy Life) (Early life programming of childhood health project [number 696295; 2017], ZonMW, The Netherlands [number 529051014; 2017]). Dr. Guxens received funding from the Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (EST-18 RF-25). The views expressed are those of the author(s) and not necessarily those of the National Institute for Health Research or the Department of Health and Social Care.

Published
2021
Full Text
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10. Advancing tools for human early lifecourse exposome research and translation (ATHLETE)

Author

Vrijheid, Martine, Basagaña, Xavier, Gonzalez, Juan R., Jaddoe, Vincent W.V., Jensen, Genon, Keun, Hector C., McEachan, Rosemary R.C., Porcel, Joana, Siroux, Valerie, Swertz, Morris A., Thomsen, Cathrine, Aasvang, Gunn Marit, Andrušaitytė, Sandra, Angeli, Karine, Avraam, Demetris, Ballester, Ferran, Burton, Paul, Bustamante, Mariona, Casas, Maribel, Chatzi, Leda, Chevrier, Cécile, Cingotti, Natacha, Conti, David, Crépet, Amélie, Dadvand, Payam, Duijts, Liesbeth, van Enckevort, Esther, Esplugues, Ana, Fossati, Serena, Garlantezec, Ronan, Roig, María Dolores Gómez, Grazuleviciene, Regina, Gützkow, Kristine B., Guxens, Mònica, Haakma, Sido, Hessel, Ellen V.S., Hoyles, Lesley, Hyde, Eleanor, Klanova, Jana, van Klaveren, Jacob D., Kortenkamp, Andreas, Le Brusquet, Laurent, Leenen, Ivonne, Lertxundi, Aitana, Lertxundi, Nerea, Lionis, Christos, Llop, Sabrina, Lopez-Espinosa, Maria Jose, Lyon-Caen, Sarah, Maitre, Lea, Mason, Dan, Mathy, Sandrine, Mazarico, Edurne, Nawrot, Tim, Pedersen, Marie, Ortiz, Rodney, Perelló, Josep, Pérez-Cruz, Míriam, Philippat, Claire, Piler, Pavel, Pizzi, Costanza, Quentin, Joane, Richiardi, Lorenzo, Rodriguez, Adrian, Roumeliotaki, Theano, Capote, José Manuel Sabin, Santiago, Leonardo, Santos, Susana, Siskos, Alexandros P., Strandberg-Larsen, Katrine, Stratakis, Nikos, Sunyer, Jordi, Tenenhaus, Arthur, Vafeiadi, Marina, Wilson, Rebecca C., Wright, John, Yang, Tiffany, and Slama, Remy

Subjects
Child health, Exposome, Exposure assessment, Adolescent health, Early life
Abstract

Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE's results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.

Published
2021
Full Text
View/download PDF

12. Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)

Author

Isabelle Thierry-Chef, Beate Timmermann, Neige Journy, Marie-Odile Bernier, Richard McNally, Jérémie Dabin, Lorenzo Brualla, Siamak Haghdoost, Adelaida Sarukhan, Karin Haustermans, Inge De Wit, Sofie Isebaert, Yasmin Lassen-Ramshad, Louise Tram Henriksen, Morten Høyer, Laura Toussaint, Guillaume Boissonnat, Juliette Thariat, Charlotte Demoor-Goldschmidt, Nadia Haddy, Stéphanie Bolle, Brice Fresneau, Amel Belhout, Steffen Dreger, Hajo Zeeb, Maria Grazia Andreassi, Jonica Campolo, Eugenio Picano, Andreas Jahnen, Cécile Ronckers, John H. Maduro, Kristina Kjaerheim, Gaute Døhlen, Trude Eid Robsahm, Hilde M. Olerud, Utheya Salini Thevathas, Susmita Afroz, Bjørn Helge Østerås, Uwe Schneider, Linda Walsh, Agnès Dumas, Angéla Jackson, Estelle Rage, Marijke De Saint-Hubert, Richard Hardy, Christian Bäumer, Theresa Steinmeier, Suzan Botzenhardt, Martina Wette, Rodney Ortiz, Vadim Chumak, Thierry-Chef, Isabelle, Sarukhan, Adelaida, Ortiz, Rodney, and Chumak, Vadim

Subjects
Technology, Science & Technology, PROTON THERAPY, CT SCANS, CHILDHOOD, Medizin, CANCER-RISK, INTENSITY-MODULATED PHOTON, CHILDREN, General Medicine, PATIENT, SUBSEQUENT RISK, DOSE CALCULATION, MONTE-CARLO-SIMULATION, Nuclear Science & Technology
Abstract

The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.

Published
2023

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