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Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)

Authors :
Thierry-Chef Isabelle
Timmermann Beate
Journy Neige
Bernier Marie-Odile
McNally Richard
Dabin Jérémie
Brualla Lorenzo
Haghdoost Siamak
Sarukhan Adelaida
Haustermans Karin
De Wit Inge
Isebaert Sofie
Lassen-Ramshad Yasmin
Tram Henriksen Louise
Høyer Morten
Toussaint Laura
Boissonnat Guillaume
Thariat Juliette
Demoor-Goldschmidt Charlotte
Haddy Nadia
Bolle Stéphanie
Fresneau Brice
Belhout Amel
Dreger Steffen
Zeeb Hajo
Grazia Andreassi Maria
Campolo Jonica
Picano Eugenio
Jahnen Andreas
Ronckers Cécile
Maduro John H.
Kjaerheim Kristina
Døhlen Gaute
Robsahm Trude Eid
Olerud Hilde M.
Thevathas Utheya Salini
Afroz Susmita
Helge Østerås Bjørn
Schneider Uwe
Walsh Linda
Dumas Agnès
Jackson Angéla
Rage Estelle
De Saint-Hubert Marijke
Hardy Richard
Bäumer Christian
Steinmeier Theresa
Botzenhardt Suzan
Wette Martina
Ortiz Rodney
Chumak Vadim
Source :
EPJ Nuclear Sciences & Technologies, Vol 9, p 22 (2023)
Publication Year :
2023
Publisher :
EDP Sciences, 2023.

Abstract

The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.

Details

Language :
English
ISSN :
24919292
Volume :
9
Database :
Directory of Open Access Journals
Journal :
EPJ Nuclear Sciences & Technologies
Publication Type :
Academic Journal
Accession number :
edsdoj.5848e4ad4ed94b4b81ed0373a4489aa1
Document Type :
article
Full Text :
https://doi.org/10.1051/epjn/2023009