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Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)

Authors :
Isabelle Thierry-Chef
Beate Timmermann
Neige Journy
Marie-Odile Bernier
Richard McNally
Jérémie Dabin
Lorenzo Brualla
Siamak Haghdoost
Adelaida Sarukhan
Karin Haustermans
Inge De Wit
Sofie Isebaert
Yasmin Lassen-Ramshad
Louise Tram Henriksen
Morten Høyer
Laura Toussaint
Guillaume Boissonnat
Juliette Thariat
Charlotte Demoor-Goldschmidt
Nadia Haddy
Stéphanie Bolle
Brice Fresneau
Amel Belhout
Steffen Dreger
Hajo Zeeb
Maria Grazia Andreassi
Jonica Campolo
Eugenio Picano
Andreas Jahnen
Cécile Ronckers
John H. Maduro
Kristina Kjaerheim
Gaute Døhlen
Trude Eid Robsahm
Hilde M. Olerud
Utheya Salini Thevathas
Susmita Afroz
Bjørn Helge Østerås
Uwe Schneider
Linda Walsh
Agnès Dumas
Angéla Jackson
Estelle Rage
Marijke De Saint-Hubert
Richard Hardy
Christian Bäumer
Theresa Steinmeier
Suzan Botzenhardt
Martina Wette
Rodney Ortiz
Vadim Chumak
Thierry-Chef, Isabelle
Sarukhan, Adelaida
Ortiz, Rodney
Chumak, Vadim
Source :
EPJ Nuclear Sciences & Technologies, 9:22
Publication Year :
2023

Abstract

The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.

Details

Language :
English
Database :
OpenAIRE
Journal :
EPJ Nuclear Sciences & Technologies, 9:22
Accession number :
edsair.doi.dedup.....617cb6220a0ac50bf576bd521653daeb