376 results on '"Ophthalmic disease"'
Search Results
2. Sulforaphane and ophthalmic diseases.
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Zhang, Yichi, Zhao, Xiaojing, Liu, Yang, and Yang, Xiuxia
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MACULAR degeneration , *DIABETIC retinopathy , *CHEMICAL formulas , *CELL death , *MEDICAL research - Abstract
Sulforaphane (SFN) is an organosulfur compound categorized as an isothiocyanate (ITC), primarily extracted from cruciferous vegetables like broccoli and cabbage. The molecular formula of sulforaphane (SFN) is C6H11NOS2. SFN is generated by the hydrolysis of glucoraphanin (GRP) through the enzyme myrosinase, showing notable properties including anti‐diabetic, anti‐inflammatory, antimicrobial, anti‐angiogenic, and anticancer attributes. Ongoing clinical trials are investigating its potential in diseases such as cancer, neurodegenerative diseases, diabetes‐related complications, chronic kidney disease, cardiovascular disease, and liver diseases. Several animal carcinogenesis models and cell culture models have shown it to be a very effective chemopreventive agent, and the protective effects of SFN in ophthalmic diseases have been linked to multiple mechanisms. In murine models of diabetic retinopathy and age‐related macular degeneration, SFN delays retinal photoreceptor cell degeneration through the Nrf2 antioxidative pathway, NF‐κB pathway, AMPK pathway, and Txnip/mTOR pathway. In rabbit models of keratoconus and cataract, SFN has been shown to protect corneal and lens epithelial cells from oxidative stress injury by activating the Keap1‐Nrf2‐ARE pathway and the Nrf‐2/HO‐1 antioxidant pathway. Oral delivery or intraperitoneal injection at varying concentrations are the primary strategies for SFN intake in current preclinical studies. Challenges remain in the application of SFN in eye disorders due to its weak solubility in water and limited bioavailability because of the presence of blood–ocular barrier systems. This review comprehensively outlines recent research on SFN, elucidates its mechanisms of action, and discusses potential therapeutic benefits for eye disorders such as age‐related macular degeneration (AMD), diabetic retinopathy (DR), cataracts, and other ophthalmic diseases, while also indicating directions for future clinical research to achieve efficient SFN treatment for ophthalmic diseases. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Sulforaphane and ophthalmic diseases
- Author
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Yichi Zhang, Xiaojing Zhao, Yang Liu, and Xiuxia Yang
- Subjects
age‐related macular degeneration ,cataract ,diabetic retinopathy ,ophthalmic disease ,sulforaphane ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Abstract Sulforaphane (SFN) is an organosulfur compound categorized as an isothiocyanate (ITC), primarily extracted from cruciferous vegetables like broccoli and cabbage. The molecular formula of sulforaphane (SFN) is C6H11NOS2. SFN is generated by the hydrolysis of glucoraphanin (GRP) through the enzyme myrosinase, showing notable properties including anti‐diabetic, anti‐inflammatory, antimicrobial, anti‐angiogenic, and anticancer attributes. Ongoing clinical trials are investigating its potential in diseases such as cancer, neurodegenerative diseases, diabetes‐related complications, chronic kidney disease, cardiovascular disease, and liver diseases. Several animal carcinogenesis models and cell culture models have shown it to be a very effective chemopreventive agent, and the protective effects of SFN in ophthalmic diseases have been linked to multiple mechanisms. In murine models of diabetic retinopathy and age‐related macular degeneration, SFN delays retinal photoreceptor cell degeneration through the Nrf2 antioxidative pathway, NF‐κB pathway, AMPK pathway, and Txnip/mTOR pathway. In rabbit models of keratoconus and cataract, SFN has been shown to protect corneal and lens epithelial cells from oxidative stress injury by activating the Keap1‐Nrf2‐ARE pathway and the Nrf‐2/HO‐1 antioxidant pathway. Oral delivery or intraperitoneal injection at varying concentrations are the primary strategies for SFN intake in current preclinical studies. Challenges remain in the application of SFN in eye disorders due to its weak solubility in water and limited bioavailability because of the presence of blood–ocular barrier systems. This review comprehensively outlines recent research on SFN, elucidates its mechanisms of action, and discusses potential therapeutic benefits for eye disorders such as age‐related macular degeneration (AMD), diabetic retinopathy (DR), cataracts, and other ophthalmic diseases, while also indicating directions for future clinical research to achieve efficient SFN treatment for ophthalmic diseases.
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- 2024
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4. The Accumulation of Senescent Cells and Diseases
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Bennett, Gabriel, Bennett, Gabriel, Series Editor, and Goodall, Emma, Series Editor
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- 2024
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5. Applications of deep learning for detecting ophthalmic diseases with ultrawide-field fundus images
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Qing-Qing Tang, Xiang-Gang Yang, Hong-Qiu Wang, Da-Wen Wu, and Mei-Xia Zhang
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ultrawide-field fundus images ,deep learning ,disease diagnosis ,ophthalmic disease ,Ophthalmology ,RE1-994 - Abstract
AIM: To summarize the application of deep learning in detecting ophthalmic disease with ultrawide-field fundus images and analyze the advantages, limitations, and possible solutions common to all tasks. METHODS: We searched three academic databases, including PubMed, Web of Science, and Ovid, with the date of August 2022. We matched and screened according to the target keywords and publication year and retrieved a total of 4358 research papers according to the keywords, of which 23 studies were retrieved on applying deep learning in diagnosing ophthalmic disease with ultrawide-field images. RESULTS: Deep learning in ultrawide-field images can detect various ophthalmic diseases and achieve great performance, including diabetic retinopathy, glaucoma, age-related macular degeneration, retinal vein occlusions, retinal detachment, and other peripheral retinal diseases. Compared to fundus images, the ultrawide-field fundus scanning laser ophthalmoscopy enables the capture of the ocular fundus up to 200° in a single exposure, which can observe more areas of the retina. CONCLUSION: The combination of ultrawide-field fundus images and artificial intelligence will achieve great performance in diagnosing multiple ophthalmic diseases in the future.
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- 2024
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6. Ophthalmic Diseases Classification Based on YOLOv8.
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Khalaf, Ahmed Tuama and Abdulateef, Salwa Khalid
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NOSOLOGY ,RETINAL vein occlusion ,RETINAL diseases ,MACULAR degeneration ,EYE diseases ,PHASE coding - Abstract
With the rising prevalence of retinal diseases, identifying eye diseases at an early stage is crucial for effective treatment and prevention of irreversible blindness. But Ophthalmologists face challenges in detecting subtle symptoms that may indicate the presence of a disease before it progresses to an advanced stage Among these challenges, eye diseases can present with a wide range of symptoms, and some conditions may share similar signs. To solve these difficulties, in the research proposed YOLOV8(You Only Look Once) Lightweight Self-Attention model to classify seven different retinal diseases. In this regard, the dataset that have been used in this study contains 5787 images from three different sources (Roboflow, Kaggle and Medical Clinics) were included in the seven classes of Glaucoma, Age-related Macular Degeneration (AMD), Cataract, Diabetic retinopathy (DR), and Retinal Vein Occlusion, which comprises of Branch Retinal Vein Occlusion (BRVO) and Central Retinal Occlusion (CRVO) and normal. As a results, the model has proven excellent performance in its classification ability. Boasting an average classification accuracy of 94% across the seven disease with precsition 96.2%, recall 96.6%and f1 score was 96.3% At the time of training it was 0.6 Houres(H). When compaired with Resnet50, VGG16 results underscore the model's superior performance in precision and computational efficiency compared. The algorithm's evaluation reveals its superiority when compared to earlier pertinent research, making it a trustworthy method for classifying retinal illnesses. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Pediatric IgG4-related disease: a descriptive review.
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Hara, Satoshi, Yoshida, Misaki, Sanada, Hajime, Suzuki, Yasunori, Sato, Yasuharu, Mizushima, Ichiro, and Kawano, Mitsuhiro
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PLASMA cells ,GENITALIA ,PEDIATRIC therapy ,LITERATURE reviews ,PHYSICIANS - Abstract
IgG4-related disease (IgG4-RD) is an immune-mediated systemic fibroinflammatory condition characterized by serum IgG4 elevation and IgG4-positive plasma cell infiltration into various organs. It generally occurs in elderly males. Pediatric cases have been reported, albeit rarely, accordingly lack of recognition of such cases could delay therapeutic intervention leading to poorer outcomes. The present review is a descriptive review of all published case reports, cohort studies, and reviews of pediatric IgG4-RD listed in PubMed. Characteristics of pediatric IgG4-RD were clarified, including sex, organ involvement, serological and histological findings, and treatment. We assessed how many published cases met current classification and comprehensive diagnostic criteria. The characteristics of pediatricIgG4-RD differed from adult IgG4-RD in terms of sex and involved organs. There was no clear male dominance in numbers of cases, and surface organ involvement such as ophthalmic diseases were more common in the pediatric IgG4-RD. Organ involvement tended to be indolent and unilateral, causing difficulty in definitively diagnosing pediatric IgG4-RD. Only about 20% of published cases met IgG4-RD classification or comprehensive diagnostic criteria. Physicians should be careful in diagnosing pediatric IgG4-RD after excluding mimickers. International collaboration toward high-quality evidence to support diagnosis and treatment of pediatric IgG4-RD is advised. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Novel coronavirus infection and its vaccination-related ocular disease
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Lu-Xuan Wang, Zuo-Xiang Pang, Rong-Yu Gao, and Lei Gao
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sars-cov-2 ,covid-19 ,covid-19 vaccine ,ophthalmic disease ,ocular surface disease ,uveal and retinal disease ,cranial nerve lesions ,Ophthalmology ,RE1-994 - Abstract
The continuous pandemic coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)is a serious threat to human life and health because of high infectious pathogenicity, and it also has posed a new challenge to the current medical model. Many literatures have shown that these changes range from the more common ocular surface diseases such as inflammation of the cornea, conjunctiva, and sclera, to the relatively rare paracentral acute middle maculopathy and acute macular neuroretinopathy. For patients with ocular symptoms as the first or accompanying symptoms of SARS-CoV-2 infection, how to identify the correlation between ocular manifestations and SARS-CoV-2 infection is undoubtedly a serious challenge for ophthalmologists. In this review, the ocular pathology caused by both SARS-CoV-2 infection and vaccination was discussed, covering pathological changes in the ocular surface, uvea, retina and macula, and cranial nerves.
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- 2023
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9. 基于深度学习的眼科超声图像智能辅助诊断 方法研究.
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李泽萌, 王晓春, 王效宁, and 周盛
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Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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10. The impact of COVID-19 on managing ophthalmic diseases: an international, descriptive study.
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Waisberg, Ethan, Ong, Joshua, Zaman, Nasif, Kamran, Sharif Amit, Tavakkoli, Alireza, and Lee, Andrew G.
- Abstract
Background : Anecdotally, the COVID-19 pandemic has resulted in more severe cases of eye disease, decreased medication compliance/availability, and decreased treatment volume due to the lockdown. Aims: We aim to quantify and bring together a variety of international perspectives from ophthalmologists of different subspecialties to characterize the global impact of COVID-19 on managing various ophthalmic disease. Methods: An online survey of 10 questions was conducted among ophthalmologists using a specialized survey program. Results: Fifty-two ophthalmologists were successfully contacted. Survey respondents include ophthalmologists from USA, Canada, Korea, Mexico, and New Zealand. Based on the results of our survey, 1 year after the pandemic, ophthalmic disease severity has worsened as well as a decrease in examination and medication compliance. Conclusions: Ophthalmologists across the world have reported a general increase in disease severity and decrease in medication and examination compliance 1 year after the beginning of COVID-19. [ABSTRACT FROM AUTHOR]
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- 2023
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11. Editorial: Ophthalmic disease and quality of life
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Ioanna Mylona, Mario Damiano Toro, and Asimina Mataftsi
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ophthalmic disease ,quality of life ,health outcomes ,PROM (patient reported outcome measures) ,vision related quality life ,Medicine (General) ,R5-920 - Published
- 2023
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12. Development of a Temperature and Heat Flux Measurement System Based on Microcontroller and its Application in Ophthalmology
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Wang Chunzhi, Jiao Hongzhe, Anatychuk Lukyan, Pasyechnikova Nataliya, Naumenko Volodymyr, Zadorozhnyy Oleg, Vikhor Lyudmyla, Kobylianskyi Roman, Fedoriv Roman, and Kochan Orest
- Subjects
thermocouple ,temperature ,heat flux ,thermoelectric medical device ,heat flux sensor ,ophthalmology ,ophthalmic disease ,Mathematics ,QA1-939 - Abstract
The paper describes the design and technical parameters of a medical thermoelectric device developed for diagnosing and monitoring the ophthalmic diseases. The main elements of the device are a specially designed thermoelectric heat flux sensor and a thermocouple temperature sensor connected to a data acquisition unit. The sensor is a thermoelectric micro-module that converts the heat flux into an electric voltage, which is recorded by the measuring channel of the data acquisition unit. The device allows high-precision measurements of both heat flux and temperature from the ocular surface. The paper contains examples of clinical piloting of the device.
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- 2022
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13. Research progress on the role of circular RNA in eye diseases
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Li-Rong Zou and Xin-Ling Wang
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non-coding rna ,circular rna ,ophthalmic disease ,Ophthalmology ,RE1-994 - Abstract
Circular RNA(circRNA)is a single-stranded covalently closed RNA molecule produced by reverse splicing, which is an evolutionarily conserved and stable transcript, and widely exists in various eukaryotic cells. CircRNA is more stable and conserved than linear transcripts because of the absence of 5'cap and 3'polyadenylation tail in circRNA. A variety of bioactive processes are regulated by circRNA, such as cell differentiation, proliferation, angiogenesis and cell apoptosis. CircRNAs were shown to be key regulators of various diseases, especially cancers, neurodegenerative and cardiovascular. Recently, with the rapid development of RNA high-throughput sequencing technology, accumulating evidence shows that there are multiple differentially expressed circRNAs in ocular tissues and they play important roles in initiation, progression, and prognosis of diverse ocular diseases, such as glaucoma, cataract, retinopathy, ocular tumors and ocular immunologic diseases. In this article, the research on the relationship between circRNA and ophthalmic diseases in the recent years is briefly reviewed, and the purpose is to provide reference for its clinical treatment and prognosis.
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- 2022
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14. Editorial: Non-coding RNAs in ophthalmic diseases
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Yedi Zhou, Songshan Li, and Shigeo Yoshida
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non-coding RNA ,ophthalmic disease ,microRNA ,long non-coding RNA ,circular RNA ,tRNA-related fragments ,Genetics ,QH426-470 - Published
- 2022
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15. Research progress of circular RNA in ophthalmic diseases
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Lian Shu, Xiao-Xiao Chen, and Xing-Huai Sun
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circular rna ,ophthalmic disease ,non-coding rna ,microrna ,Ophthalmology ,RE1-994 - Abstract
With the rapid development of molecular biology technologies such as whole-genome testing in the past decade, non-coding RNA has been deeply explored. Circular RNA(circRNA)gradually becomes a hot topic in recent years, which plays an important role in the occurrence and development of a variety of diseases, and relevant studies have been carried out in ophthalmological diseases. This article will review the mechanism, basic research, and clinical findings of circRNA in various ophthalmic diseases, and briefly discuss the potential clinical significance of circRNA in ophthalmic diseases.
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- 2021
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16. Systematic Bibliometric and Visualized Analysis of Research Hotspots and Trends on the Application of Artificial Intelligence in Ophthalmic Disease Diagnosis.
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Zhao, Junqiang, Lu, Yi, Zhu, Shaojun, Li, Keran, Jiang, Qin, and Yang, Weihua
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ARTIFICIAL intelligence ,DIAGNOSIS ,COMPUTER engineering ,BIBLIOMETRICS ,BROWNIAN motion ,EYE tracking - Abstract
Background: Artificial intelligence (AI) has been used in the research of ophthalmic disease diagnosis, and it may have an impact on medical and ophthalmic practice in the future. This study explores the general application and research frontier of artificial intelligence in ophthalmic disease detection. Methods: Citation data were downloaded from the Web of Science Core Collection database to evaluate the extent of the application of Artificial intelligence in ophthalmic disease diagnosis in publications from 1 January 2012, to 31 December 2021. This information was analyzed using CiteSpace.5.8. R3 and Vosviewer. Results: A total of 1,498 publications from 95 areas were examined, of which the United States was determined to be the most influential country in this research field. The largest cluster labeled "Brownian motion" was used prior to the application of AI for ophthalmic diagnosis from 2007 to 2017, and was an active topic during this period. The burst keywords in the period from 2020 to 2021 were system, disease, and model. Conclusion: The focus of artificial intelligence research in ophthalmic disease diagnosis has transitioned from the development of AI algorithms and the analysis of abnormal eye physiological structure to the investigation of more mature ophthalmic disease diagnosis systems. However, there is a need for further studies in ophthalmology and computer engineering. [ABSTRACT FROM AUTHOR]
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- 2022
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17. HODD: A Manually Curated Database of Human Ophthalmic Diseases with Symptom Characteristics and Genetic Variants Towards Facilitating Quick and Definite Diagnosis.
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Zhang, Zhaotian, Tang, Qiang, Wang, Qiong, Nie, Fulei, Sun, Limei, Luo, Delun, Chen, Wei, and Ding, Xiaoyan
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GENETIC variation ,SYMPTOMS ,PROTEIN-protein interactions ,DATABASES ,DIAGNOSIS - Abstract
Ophthalmic diseases are disorders that affect the eyes. Hundreds of causal genes and biological pathways have been reported to be closely correlated with ophthalmic diseases. However, these information are scattered across various resources, which has hindered a thorough and deep understanding of ophthalmic diseases. In the present work, we proposed the Human Ophthalmic Diseases Database (HODD), which currently deposits 730 ophthalmic diseases and 653 related genes and is available at http://bio-bigdata.cn/HODD/. The disease-related information and genes related to ophthalmic diseases were collected from the several well-known databases. To comprehensively understand the ophthalmic diseases, the basic information was provided for each disease, including disease description, related genes, gene location, ocular and extraocular effect of the disease, protein–protein interaction and disease-associated pathways. All these data were reorganized and made accessible through multiple entrances. We hope that HODD will facilitate studies on ophthalmic diseases. The workflow for the construction of the HODD (Human Ophthalmic Diseases Database, http://bio-bigdata.cn/HODD/) database. [ABSTRACT FROM AUTHOR]
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- 2022
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18. The prevalence of anxiety symptoms and disorders among ophthalmic disease patients.
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Ulhaq, Zulvikar Syambani, Soraya, Gita Vita, Dewi, Nadia Artha, and Wulandari, Lely Retno
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ONLINE information services ,META-analysis ,CONFIDENCE intervals ,SYSTEMATIC reviews ,DISEASE prevalence ,ANXIETY ,MEDLINE ,ODDS ratio ,EYE diseases - Abstract
Background: Progressive and irreversible vision loss has been shown to place a patient at risk of mental health problems such as anxiety. However, the reported prevalence of anxiety symptoms and disorders among eye disease patients vary across studies. Thus, this study aims to clarify the estimated prevalence of anxiety symptoms and disorders among ophthalmic disease patients. Methods: Relevant studies on the prevalence of anxiety symptoms and disorders among eye disease patients were collected through international databases, PubMed, Scopus, and Web of Science. A random-effects model was used to determine the pooled prevalence of anxiety symptoms and disorders among ophthalmic disease patients. Results: The 95 included studies yielded a pooled prevalence of 31.2% patients with anxiety symptoms and 19.0% with anxiety disorders among subjects with ophthalmic disease. Pediatric patients were more anxious (58.6%) than adults (29%). Anxiety symptoms were most prevalent in uveitis (53.5%), followed by dry eye disease (DED, 37.2%), retinitis pigmentosa (RP, 36.5%), diabetic retinopathy (DR, 31.3%), glaucoma (30.7%), myopia (24.7%), age-related macular degeneration (AMD, 21.6%), and cataract (21.2%) patients. Anxiety disorders were most prevalent in thyroid eye disease (TED, 28.9%), followed by glaucoma (22.2%) and DED (11.4%). When compared with healthy controls, there was a twofold increase on the prevalence of anxiety symptoms (OR = 1.912, 95% CI 1.463–2.5, p < 0.001) and anxiety disorders (OR = 2.281, 95% CI 1.168–4.454, p = 0.016). Conclusion: Anxiety symptoms and disorders are common problems associated with ophthalmic disease patients. Thus, comprehensive and appropriate treatments are necessary for treating anxiety symptoms and disorders among ophthalmic disease patients. [ABSTRACT FROM AUTHOR]
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- 2022
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19. New Ophthalmic Disease Study Findings Recently Were Reported by Researchers at Mount Sinai Hospital (The Relationship Between Dry Eye Disease and Human Microbiota: a Review of the Science).
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- 2024
20. Researchers at CHA University Have Published New Data on Ophthalmic Disease (Unraveling the Clinical Features and Outcomes of IgG4-Related Ophthalmic Disease).
- Abstract
Researchers at CHA University in South Korea have conducted a study on IgG4-related ophthalmic disease (IgG4-ROD), a condition characterized by lymphoplasmacytic infiltration, fibrosis, and elevated IgG4 levels. The study aimed to examine the clinical features and outcomes of IgG4-ROD. The researchers conducted a retrospective study on 33 patients diagnosed with IgG4-ROD and compared their demographic characteristics with 37 patients diagnosed with IgG4-related disease (IgG4-RD) in other departments. The study found that a combination therapy of glucocorticosteroid (GCS) and steroid-sparing agents (SSAs) was effective in treating IgG4-ROD, and hydroxychloroquine (HCQ) could be considered as a potential adjunctive therapy. [Extracted from the article]
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- 2024
21. Findings from Doheny Eye Institute Update Knowledge of Ophthalmic Disease (Biosimilars of Anti-vascular Endothelial Growth Factor for Ophthalmic Diseases: a Review).
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A recent study conducted by the Doheny Eye Institute in Pasadena, California, explores the use of biosimilars as a cost-effective alternative to branded agents for treating ophthalmic diseases. The study highlights the potential benefits of biosimilars, which have been shown to be clinically equivalent to reference products. Specifically, the study focuses on anti-vascular endothelial growth factor (VEGF) biosimilars and discusses the regulatory and scientific concepts surrounding their development, as well as the challenges and opportunities associated with their uptake in ophthalmology. This research has been peer-reviewed and provides valuable insights for healthcare systems and patients seeking affordable treatment options. [Extracted from the article]
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- 2024
22. Customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo
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Huangxuan Zhao, Ke Li, Fan Yang, Wenhui Zhou, Ningbo Chen, Liang Song, Chuansheng Zheng, Zhicheng Liu, and Chengbo Liu
- Subjects
photoacoustic imaging ,ophthalmic imaging ,morphologic and functional information ,ophthalmic disease ,anterior segment ,Optics. Light ,QC350-467 - Abstract
Photoacoustic imaging has many advantages in ophthalmic application including high-resolution, requirement of no exogenous contrast agent, and noninvasive acquisition of both morphologic and functional information. However, due to the limited depth of focus of the imaging method and large curvature of the eye, it remains a challenge to obtain high quality vascular image of entire anterior segment. Here, we proposed a new method to achieve high quality imaging of anterior segment. The new method applied a curvature imaging strategy based on only one time scanning, and hence is time efficient and more suitable for ophthalmic imaging compared to previously reported methods using similar strategy. A custom-built photoacoustic imaging system was adapted for ophthalmic application and a customized image processing method was developed to quantitatively analyze both morphologic and functional information in vasculature of the anterior segment. The results showed that the new method improved the image quality of anterior segment significantly compared to that of conventional high resolution photoacoustic imaging. More importantly, we applied the new method to study ophthalmic disease in an in vivo mouse model for the first time. The results verified the suitability and advantages of the new method for imaging the entire anterior segment and the numerous potentials of applying it in ophthalmic imaging in future.
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- 2021
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23. Systematic Bibliometric and Visualized Analysis of Research Hotspots and Trends on the Application of Artificial Intelligence in Ophthalmic Disease Diagnosis
- Author
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Junqiang Zhao, Yi Lu, Shaojun Zhu, Keran Li, Qin Jiang, and Weihua Yang
- Subjects
ophthalmic disease ,artificial intelligence ,diagnosis ,bibliometric ,CiteSpace ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: Artificial intelligence (AI) has been used in the research of ophthalmic disease diagnosis, and it may have an impact on medical and ophthalmic practice in the future. This study explores the general application and research frontier of artificial intelligence in ophthalmic disease detection.Methods: Citation data were downloaded from the Web of Science Core Collection database to evaluate the extent of the application of Artificial intelligence in ophthalmic disease diagnosis in publications from 1 January 2012, to 31 December 2021. This information was analyzed using CiteSpace.5.8. R3 and Vosviewer.Results: A total of 1,498 publications from 95 areas were examined, of which the United States was determined to be the most influential country in this research field. The largest cluster labeled “Brownian motion” was used prior to the application of AI for ophthalmic diagnosis from 2007 to 2017, and was an active topic during this period. The burst keywords in the period from 2020 to 2021 were system, disease, and model.Conclusion: The focus of artificial intelligence research in ophthalmic disease diagnosis has transitioned from the development of AI algorithms and the analysis of abnormal eye physiological structure to the investigation of more mature ophthalmic disease diagnosis systems. However, there is a need for further studies in ophthalmology and computer engineering.
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- 2022
- Full Text
- View/download PDF
24. Injectable hydrogels based on biopolymers for the treatment of ocular diseases.
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Yu, Caiyu, Xu, Jiahao, Heidari, Golnaz, Jiang, Huijun, Shi, Yifeng, Wu, Aimin, Makvandi, Pooyan, Neisiany, Rasoul Esmaeely, Zare, Ehsan Nazarzadeh, Shao, Minmin, and Hu, Liang
- Subjects
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THERAPEUTICS , *MACULAR degeneration , *HYDROGELS , *OPHTHALMOLOGICAL therapeutics , *DIABETIC retinopathy , *TISSUE scaffolds , *BIOPOLYMERS - Abstract
Injectable hydrogels based on biopolymers, fabricated utilizing diverse chemical and physical methodologies, exhibit exceptional physical, chemical, and biological properties. They have multifaceted applications encompassing wound healing, tissue regeneration, and across diverse scientific realms. This review critically evaluates their largely uncharted potential in ophthalmology, elucidating their diverse applications across an array of ocular diseases. These conditions include glaucoma, cataracts, corneal disorders (spanning from age-related degeneration to trauma, infections, and underlying chronic illnesses), retina-associated ailments (such as diabetic retinopathy, retinitis pigmentosa, and age-related macular degeneration (AMD)), eyelid abnormalities, and uveal melanoma (UM). This study provides a thorough analysis of applications of injectable hydrogels based on biopolymers across these ocular disorders. Injectable hydrogels based on biopolymers can be customized to have specific physical, chemical, and biological properties that make them suitable as drug delivery vehicles, tissue scaffolds, and sealants in the eye. For example, they can be engineered to have optimum viscosity to be injected intravitreally and sustain drug release to treat retinal diseases. Their porous structure and biocompatibility promote cellular infiltration to regenerate diseased corneal tissue. By accentuating their indispensable role in ocular disease treatment, this review strives to present innovative and targeted approaches in this domain, thereby advancing ocular therapeutics. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2024
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25. Computer-Aided Diagnosis of Ophthalmic Diseases Using OCT Based on Deep Learning: A Review
- Author
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Zhang, Ruru, He, Jiawen, Shi, Shenda, Kang, Xiaoyang, Chai, Wenjun, Lu, Meng, Liu, Yu, Haihong, E., Ou, Zhonghong, Song, Meina, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Milošević, Danijela, editor, Tang, Yong, editor, and Zu, Qiaohong, editor
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- 2019
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26. Clinical Profile of Ocular Diseases at a Tertiary Eye Care Centre in Mid-Western Nepal
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Pragya Singh Basnet, Sagun Malla, Deepa Sharma, and Roshan Gautam
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cataract ,conjunctivitis ,ophthalmic disease ,rural area ,Medicine - Abstract
Introduction: Nepal is a developing country where most of the population does not have access to proper health care services and on top of that eye care services do not reach the entire population. This study aimed to determine the pattern of ocular morbidity in patients attending the ophthalmic OPD of Rapti Academy of Health Sciences. Materials and Methods: This was a prospective cross-sectional study conducted in the Department of Ophthalmology of Rapti Academy of Health Science, Dang. The study period was Poush 2077 to Chaitra 2077. All the patients visiting the OPD of the Ophthalmology department with an ocular problem were included in the study. Results: A total of 1000 patients were examined during the study period. The patient's ages below 1 year were excluded so a total of 970 samples was selected. In which 625 (64.4%) were female and 345 (35.6%) were male. Most patients 92.9% were from Dang followed by Rolpa 4.1%, Rukum 1.4%, Pyuthan 0.9%, and Salyan 0.6%. Patients were examined from all age groups except for 1 year which was excluded. Out of the total patients, a maximum number of patients were female and the maximum number of patients were in the age group of 21- 30 years and followed by more than or equal to 60 years age group. Conclusions: This study will help in obtaining epidemiology of Ocular disease for proper planning and management in the hospital.
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- 2021
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27. The effect of COVID-19 pandemic on the attendance and clinical outcomes of patients with ophthalmic disease: A mini-review
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Maria Syriga, Ιrene Karampela, Μaria Dalamaga, and Michael Karampelas
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Pandemic ,Ophthalmic disease ,Outcome ,Retina ,Covid-19 ,Physiology ,QP1-981 ,Biochemistry ,QD415-436 - Abstract
The outbreak of COVID-19 was followed by a rapid spread leading to its declaration as a pandemic in a short time. The transmission through aerosols and direct contact with infected individuals forced the application of strict safety protocols and rearrangements in the activities of different healthcare systems around the world. Ophthalmology healthcare workers are highly exposed to viral infection and therefore adjustments were made to ensure the safety of patients and health providers by performing only urgent treatments. The suspension and delay in regular follow-up visits and the lower number of patients recorded during the lockdown period due to restrictions and patient anxiety led to severe consequences in the clinical and anatomical outcome affecting the overall prognosis. The current review aims to summarize the effect of the lockdown policies in the number and profile of patients that attended the ophthalmology clinics from different countries and analyze the effect of the pandemic in terms of vision and patient functionality. The effects of the pandemic included a reduction in the number of appointments, cancellations of non-emergency conditions and delays of surgical interventions. These had a negative effect in terms of visual outcomes.
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- 2021
- Full Text
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28. Ophthalmic Disease Prevalence and Incidence among People Living with Human Immunodeficiency Virus in the AFRICOS Study.
- Author
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Harvey, Morgan M., Dear, Nicole, Esber, Allahna, Iroezindu, Michael, Bahemana, Emmanuel, Kibuuka, Hannah, Maswai, Jonah, Owuoth, John, Crowell, Trevor A., Polyak, Christina S., Agan, Brian K., Ake, Julie A., and Justin, Grant A.
- Subjects
- *
HIV , *DISEASE prevalence , *DISEASE incidence - Published
- 2021
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29. Retinopathy and Systemic Disease Morbidity in Severe COVID-19.
- Author
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Shantha, Jessica G., Auld, Sara C, Anthony, Casey, Ward, Laura, Adelman, Max W., Maier, Cheryl L., Price, Kenneth W., Jacob, Jesse T, Fashina, Tolulope, Randleman, Casey, Xu, Lucy T., Barnett, Joshua, Sadan, Ofer, Kandiah, Prem A., Varkey, Jay B., Kraft, Colleen S., Rouphael, Nadine, Linderman, Susanne, Ahmed, Rafi, and Drews-Botsch, Carolyn
- Subjects
- *
COVID-19 , *DIABETIC retinopathy , *RETINAL artery occlusion , *INTENSIVE care units , *TREATMENT effectiveness , *MECHANICAL shock , *COMORBIDITY - Abstract
To assess the prevalence of retinopathy and its association with systemic morbidity and laboratory indices of coagulation and inflammatory dysfunction in severe COVID-19. Retrospective, observational cohort study. Adult patients hospitalized with severe COVID-19 who underwent ophthalmic examination from April to July 2020 were reviewed. Retinopathy was defined as one of the following: 1) Retinal hemorrhage; 2) Cotton wool spots; 3) Retinal vascular occlusion. We analyzed medical comorbidities, sequential organ failure assessment (SOFA) scores, clinical outcomes, and laboratory values for their association with retinopathy. Thirty-seven patients with severe COVID-19 were reviewed, the majority of whom were female (n = 23, 62%), Black (n = 26, 69%), and admitted to the intensive care unit (n = 35, 95%). Fourteen patients had retinopathy (38%) with retinal hemorrhage in 7 (19%), cotton wool spots in 8 (22%), and a branch retinal artery occlusion in 1 (3%) patient. Patients with retinopathy had higher SOFA scores than those without retinopathy (8.0 vs. 5.3, p =.03), higher rates of respiratory failure requiring invasive mechanical ventilation and shock requiring vasopressors (p <.01). Peak D-dimer levels were 28,971 ng/mL in patients with retinopathy compared to 12,575 ng/mL in those without retinopathy (p =.03). Peak CRP was higher in patients with cotton wool spots versus those without cotton wool spots (354 mg/dL vs. 268 mg/dL, p =.03). Multivariate logistic regression modeling showed an increased risk of retinopathy with higher peak D-dimers (aOR 1.32, 95% CI 1.01–1.73, p =.04) and male sex (aOR 9.6, 95% CI 1.2–75.5, p =.04). Retinopathy in severe COVID-19 was associated with greater systemic disease morbidity involving multiple organs. Given its association with coagulopathy and inflammation, retinopathy may offer insight into disease pathogenesis in patients with severe COVID-19. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
30. Data on Ophthalmic Disease Discussed by a Researcher at Jeonbuk National University Medical School (Improving the Yield of Genetic Diagnosis through Additional Genetic Panel Testing in Hereditary Ophthalmic Diseases).
- Abstract
A recent report from Jeonbuk National University Medical School in South Korea discusses the use of gene panel sequencing to improve the diagnosis of hereditary ophthalmic diseases. The study found that gene panel sequencing allowed for a greater number of patients to receive a genetic diagnosis for their clinical manifestations. Through additional gene panel sequencing, the researchers identified several genetic variants associated with hereditary ophthalmic diseases. However, fully understanding the clinical manifestations of these variants proved challenging. The study concludes that gene panel sequencing can be a valuable tool for diagnosing hereditary ophthalmic diseases, even in cases where a single genetic cause is suspected. [Extracted from the article]
- Published
- 2024
31. Wenzhou Medical University Researchers Provide New Study Findings on Artificial Intelligence (Application and progress of artificial intelligence technology in the segmentation of hyperreflective foci in OCT images for ophthalmic disease...).
- Subjects
ARTIFICIAL intelligence ,OPTICAL coherence tomography ,MEDICAL research personnel ,MACULAR degeneration ,RETINAL vein occlusion - Abstract
A study conducted by researchers at Wenzhou Medical University explores the application of artificial intelligence (AI) technology in the segmentation of hyperreflective foci (HRF) in optical coherence tomography (OCT) images for ophthalmic disease research. The study highlights the potential of AI in localizing and quantifying biomarkers, such as HRF, which can serve as indicators of retinal neuroinflammation. AI technology, including machine learning and deep learning, can aid in early screening, diagnostic grading, treatment efficacy evaluation, treatment recommendations, and prognosis development for common ophthalmic diseases. The utilization of AI has the potential to simplify clinical trials, enhance disease management, and improve the prediction of adverse events. [Extracted from the article]
- Published
- 2024
32. New Ophthalmic Disease Findings Has Been Reported by Investigators at Cleveland Clinic (Extracellular Vesicle Biomarkers In Ocular Fluids Associated With Ophthalmic Diseases).
- Abstract
A recent study conducted at the Cleveland Clinic in Ohio has focused on the role of extracellular vesicles (EVs) in ophthalmic diseases. EVs are lipid bilayer particles that carry various molecules and can indicate diseased conditions. The study highlights the identification of EV-derived biomarkers in ocular fluids for the diagnosis of ophthalmic diseases, as well as the methods used for sample collection and analysis. The research provides a roadmap for future studies on EV biomarkers in ocular fluids. This information can be found in the peer-reviewed journal Experimental Eye Research. [Extracted from the article]
- Published
- 2024
33. Shin Kong Wu Ho-Su Memorial Hospital Researcher Provides New Insights into Monkeypox (Monkeypox-related ophthalmic disease).
- Abstract
A recent report from Shin Kong Wu Ho-Su Memorial Hospital in Taipei, Taiwan, provides new insights into monkeypox, a viral infection that has been spreading worldwide since mid-2022. The report describes a case of a man who developed ocular symptoms, including blepharoconjunctivitis and preseptal cellulitis, followed by skin symptoms. Samples taken from his oropharynx and skin lesions tested positive for the monkeypox virus. The patient was treated with topical lubricant, antibiotics, and antiviral medication, but eventually developed corneal ulceration. Treatment with tecovirimat, a medication used for smallpox, was initiated, and the patient eventually experienced resolution of the corneal lesion, leaving a scar. This research provides valuable information about the ocular manifestations of monkeypox and the potential treatment options. [Extracted from the article]
- Published
- 2024
34. Patent Issued for Pharmaceutical composition (USPTO 11951103).
- Subjects
DIABETIC retinopathy ,RETINAL vein occlusion ,MACULAR degeneration ,EPIDERMAL growth factor receptors ,VASCULAR endothelial growth factors ,VASCULAR endothelial growth factor receptors - Abstract
Kyowa Kirin Co. Ltd. has been issued a patent for a pharmaceutical composition related to ophthalmic diseases. The patent describes eye drops containing a vascular endothelial growth factor (VEGF) receptor inhibitor in a nanoparticle form. The eye drops are intended for the treatment of VEGF-related diseases such as macular degeneration, retinopathy, and retinal vein occlusion. The invention aims to enhance the delivery of the VEGF receptor inhibitor to the posterior eye tissue. The patent provides detailed claims and methods for producing the eye drops. [Extracted from the article]
- Published
- 2024
35. Research progress on the role of long non-coding RNAs in eye diseases
- Author
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Xin-Ling Xu, Nai-Fang Hou, and Xin-Ling Wang
- Subjects
long non-coding rna ,ophthalmic disease ,targrt gene ,gene regulation ,gene therapy ,Ophthalmology ,RE1-994 - Abstract
Long non-coding RNAs(LncRNAs)refer to RNAs that are longer than 200 nucleotides and cannot encode a protein. With the application of next-generation sequencing technology, whole-genome analysis shows that LncRNAs can regulate gene expression in immune response, epigenetic, gene transcription and post-transcriptional levels, thereby participating in the maintenance of cell proliferation and apoptosis, tissue homeostasis and other physiological processes. LncRNAs have been shown to involve in initiation and development of a variety of human diseases in recent years. This article reviews the research progress of LncRNAs in common diseases of ophthalmology, in order to early diagnosis and treatment of related ophthalmic diseases.
- Published
- 2020
- Full Text
- View/download PDF
36. Buddleja officinalis Maxim.: A review of its botany, ethnopharmacology, phytochemistry, pharmacology, and therapeutic potential for ophthalmic diseases.
- Author
-
Wang, Meng, Wang, Shuang, Tang, Hai-Peng, Li, Jia-Yan, Zhang, Zhao-Jiong, Yang, Bing-You, and Kuang, Hai-Xue
- Subjects
- *
SKIN diseases , *PHARMACOLOGY , *INFLAMMATION , *ANTIOXIDANTS , *HYPOGLYCEMIC agents , *BIOLOGY , *PHYTOCHEMICALS , *OSTEOPOROSIS , *PLANT extracts , *EYE diseases , *CHINESE medicine , *ANTIOBESITY agents - Abstract
Buddleja officinalis Maxim. (B. officinalis), commonly known as "Menghua" "Yangerduo" is a widely recognized traditional herbal medicine in China, Korea, and Vietnam. For thousands of years, it has been used to treat dry eye disease, conjunctivitis, keratitis, eye ulcers, eye pain, cough, asthma, hemoptysis, and other medical conditions. This review article aims to provide a concise summary of the botany, ethnopharmacology, phytochemistry, pharmacology, medicinal potential, and application of B. officinalis in treating ophthalmic diseases and critically evaluates the existing literature to establish a scientific basis for its reasonable utilization and further investigation. The information reviewed in this study was collected from various electronic resources, including the Web of Science, PubMed, and Google Scholar. To date, 80 structurally diverse compounds have been isolated and characterized from B. officinalis , primarily flavonoids, phenylethanoids, triterpenoids, and monoterpenes. Extracts and compounds derived from B. officinalis have been reported to possess broad pharmacological effects including anti-dry eye disease, anti-inflammation, anti-oxidation, anti-diabetes, anti-obesity, improving osteoporosis and treatment of skin diseases. This review provides a reference for the future studies on of B. officinalis. As a natural medicinal plant, B. officinalis is worthy of further development in botany, ethnopharmacology, phytochemistry, pharmacology, and therapeutic potential for ophthalmic diseases. Although some components have demonstrated multiple pharmacological activities, their mechanisms of action remain unclear. Further studies on the underlying molecular basis and mechanism of action are warranted. [Display omitted] • B. officinalis is a common natural medicinal plant with multiple therapeutic effects. • The phytochemical compositions of B. officinalis have various biological activities. • B. officinalis has great potential to treat dry eye diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
37. Circulating exosomes in ophthalmic disease: novel carriers of biological information circulating exosomes in ophthalmic disease.
- Author
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YOU, J.-X., QI, S.-N., FU, J.-L., WANG, C.-G., and SU, G.-F.
- Abstract
Exosomes, small membrane vesicles with a diameter of 30-100 nm, transport lipids, proteins, DNA, and RNA. Exosomes originate from endocytic vessels and are processed and released through exocytosis. They can be taken up by target cells and mediate intercellular communication. Initially, exosomes were thought to be waste products excreted by cells. However, with more research, they have been found to play important roles in physiological and pathological processes. Therefore, they are promising biomarkers for the diagnosis and treatment of a variety of disease conditions, including fundus diseases, ocular surface diseases, retinal diseases, tumors, ocular trauma, and light damage. In this review, we discuss the history, biogenesis, release, isolation, characterization, and biological functions of exosomes, as well as their future application prospects in ophthalmic diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2021
38. Applications of deep learning for detecting ophthalmic diseases with ultrawide-field fundus images.
- Author
-
Tang QQ, Yang XG, Wang HQ, Wu DW, and Zhang MX
- Abstract
Aim: To summarize the application of deep learning in detecting ophthalmic disease with ultrawide-field fundus images and analyze the advantages, limitations, and possible solutions common to all tasks., Methods: We searched three academic databases, including PubMed, Web of Science, and Ovid, with the date of August 2022. We matched and screened according to the target keywords and publication year and retrieved a total of 4358 research papers according to the keywords, of which 23 studies were retrieved on applying deep learning in diagnosing ophthalmic disease with ultrawide-field images., Results: Deep learning in ultrawide-field images can detect various ophthalmic diseases and achieve great performance, including diabetic retinopathy, glaucoma, age-related macular degeneration, retinal vein occlusions, retinal detachment, and other peripheral retinal diseases. Compared to fundus images, the ultrawide-field fundus scanning laser ophthalmoscopy enables the capture of the ocular fundus up to 200° in a single exposure, which can observe more areas of the retina., Conclusion: The combination of ultrawide-field fundus images and artificial intelligence will achieve great performance in diagnosing multiple ophthalmic diseases in the future., (International Journal of Ophthalmology Press.)
- Published
- 2024
- Full Text
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39. Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases
- Author
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Jing-Yao Song, Xue-Guang Wang, Zi-Yuan Zhang, Lin Che, Bin Fan, and Guang-Yu Li
- Subjects
ER stress ,Autophagy ,UPS ,Ophthalmic disease ,Ocular ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Objective Endoplasmic reticulum (ER) stress is involved in the pathogenesis of various ophthalmic diseases, and ER stress-mediated degradation systems play an important role in maintaining ER homeostasis during ER stress. The purpose of this review is to explore the potential relationship between them and to find their equilibrium sites. Design This review illustrates the important role of reasonable regulation of the protein degradation system in ER stress-mediated ophthalmic diseases. There were 128 articles chosen for review in this study, and the keywords used for article research are ER stress, autophagy, UPS, ophthalmic disease, and ocular. Data sources The data are from Web of Science, PubMed, with no language restrictions from inception until 2019 Jul. Results The ubiquitin proteasome system (UPS) and autophagy are important degradation systems in ER stress. They can restore ER homeostasis, but if ER stress cannot be relieved in time, cell death may occur. However, they are not independent of each other, and the relationship between them is complementary. Therefore, we propose that ER stability can be achieved by adjusting the balance between them. Conclusion The degradation system of ER stress, UPS and autophagy are interrelated. Because an imbalance between the UPS and autophagy can cause cell death, regulating that balance may suppress ER stress and protect cells against pathological stress damage.
- Published
- 2020
- Full Text
- View/download PDF
40. Studies from Army Medical University Have Provided New Information about Sjogren's Syndrome (Safety and Efficacy of Oral Hydroxychloroquine In the Treatment of Ophthalmic Disease Associated With Sjogren's Syndrome).
- Subjects
SJOGREN'S syndrome ,THERAPEUTICS ,ORAL drug administration ,LACRIMAL apparatus diseases ,ORAL diseases ,XEROSTOMIA ,EHLERS-Danlos syndrome - Abstract
A study conducted by researchers at Army Medical University in Chongqing, China, has found that oral hydroxychloroquine (HCQ) is safe and effective in treating dry eye disease associated with Sjogren's syndrome (pSS). The study involved a randomized controlled trial with pSS patients who had moderate to severe dry eye disease. After 12 months of treatment, the HCQ group showed significant improvements in symptoms and test results compared to the control group. The researchers concluded that HCQ, when combined with topical cyclosporin, can improve dry eye symptoms and reduce ocular surface inflammation. [Extracted from the article]
- Published
- 2024
41. Recent Studies from Sichuan University Add New Data to Ophthalmic Disease (Applications of deep learning for detecting ophthalmic diseases with ultrawide-field fundus images).
- Abstract
A recent study from Sichuan University explores the use of deep learning in detecting ophthalmic diseases using ultrawide-field fundus images. The researchers conducted a comprehensive search of academic databases and identified 23 studies that applied deep learning to diagnose ophthalmic diseases with ultrawide-field images. The results showed that deep learning in ultrawide-field images can effectively detect various ophthalmic diseases, including diabetic retinopathy, glaucoma, age-related macular degeneration, and retinal detachment. The researchers concluded that the combination of ultrawide-field fundus images and artificial intelligence holds great potential for diagnosing multiple ophthalmic diseases in the future. [Extracted from the article]
- Published
- 2024
42. Findings on Ophthalmic Disease Detailed by Investigators at Lahore Garrison University (Deep Learning With a Novel Concoction Loss Function for Identification of Ophthalmic Disease).
- Abstract
Researchers at Lahore Garrison University in Lahore, Pakistan have developed a deep learning model combined with a unique concoction loss function (CLF) to automate the identification of ophthalmic diseases (OHD). The study focuses on common eye diseases such as cataracts, glaucoma, and age-related macular degeneration. The DL model with the proposed loss function showed reliable and efficient results in testing. The research aims to improve the performance of classifiers for biomedical data by addressing data imbalance and outliers commonly found in fundus images. [Extracted from the article]
- Published
- 2024
43. Data from Kurume University School of Medicine Advance Knowledge in Ophthalmic Disease (N6-methyladenosine methylation in ophthalmic diseases: From mechanisms to potential applications).
- Abstract
A report from Kurume University School of Medicine in Fukuoka, Japan discusses the role of N6-methyladenosine (m6A) modification in ophthalmic diseases. The research highlights the involvement of m6A modification in various physiological and pathological processes, including embryonic development, malignancy, immune regulation, and premature aging. The study also emphasizes the detection of changes in m6A modification and its metabolism in ocular diseases, as well as its role in the development and progression of ophthalmic diseases such as diabetic retinopathy, age-related macular degeneration, and melanoma. The review provides new insights into the potential applications of m6A modification in the diagnosis and treatment of ophthalmic diseases. [Extracted from the article]
- Published
- 2024
44. Poly(2-hydroxyethyl methacrylate)/β-cyclodextrin-hyaluronan contact lens with tear protein adsorption resistance and sustained drug delivery for ophthalmic diseases.
- Author
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Li, Ruicong, Guan, Xipeng, Lin, Xilin, Guan, Pengyue, Zhang, Xiong, Rao, Zhouquan, Du, Lin, Zhao, Jiafeng, Rong, Jianhua, and Zhao, Jianhao
- Subjects
CONTACT lenses ,DRUG resistance ,OPHTHALMIC drugs ,HYDROGELS ,METHACRYLATES ,ADSORPTION (Chemistry) - Abstract
A series of poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels containing cross-linked β -cyclodextrin-hyaluronan (β -CD-crHA), with tear protein adsorption resistance and sustained drug delivery, were developed as contact lens materials for eye diseases. β -CD-HA was synthesized from aminated β -CD and HA and then crosslinked within pHEMA hydrogel using polyethylenimine as a crosslinker. The synthesized β -CD-HA was characterized by
1 H NMR analysis, and β -CD-crHA immobilized in pHEMA hydrogel was confirmed by FT-IR, SEM, and AFM analyses. The incorporation of β -CD-crHA significantly improved the surface hydrophilicity, water uptake ability, oxygen permeability, and flexibility of pHEMA hydrogel, but did not compromise light transmission. pHEMA/ β -CD-crHA hydrogels not only decreased the tear protein adsorption because of the electrostatically mutual repulsion and the improved hydrophilicity, leading to the reduced adhesion of Staphylococcus aureus on the hydrogel surface, but also enhanced the encapsulation capacity and the sustainable delivery of diclofenac due to the formation of inclusion complexes between β -CD and drugs. All the hydrogels were nontoxic to 3T3 mouse fibroblasts by in vitro cell viability analysis. Among these hydrogels with different β -CD-crHA contents, pHEMA/ β -CD-crHA 10 hydrogel showed the lowest water contact angle of 52 °, the highest water content of 65%, the largest Dk value of 36.4 barrer, and the optimal modulus of 1.8 MPa, as well as a good light transmission of over 90%. The in vivo conjunctivitis treatment of rabbits for 72 h indicated that drug-loaded pHEMA/ β -CD-crHA 10 hydrogel presented a better therapeutic effect than both one dose administration of drug solution per day and drug-loaded pHEMA hydrogel. Thus, pHEMA/ β -CD-crHA 10 hydrogel is a promising contact lens material for ophthalmic diseases. Topical eye drops are currently the most popular treatment for ophthalmic diseases, but frequent dosing is necessary to acquire the desirable clinical effect at the expense of systemic side-effects. Drug-loaded contact lenses, as an alternative of eye drops, possess many good performances and show potential applications. However, the sustained drug delivery and the tear protein adsorption resistance are still challenging for contact lenses. Hence, we developed a novel pHEMA/ β -CD-crHA hydrogel by incorporating β -CD-crHA crosslinked network into pHEMA hydrogel. Besides the improvements in surface hydrophilicity, water uptake ability, oxygen permeability, and flexibility, pHEMA/ β -CD-crHA hydrogel also reduced the adsorption of tear proteins and the adhesion of Staphylococcus aureus , enhanced the drug encapsulation, and prolonged the drug delivery, with better effect in the conjunctivitis treatment of rabbits. Thus, pHEMA/ β -CD-crHA hydrogel is a potential contact lens material for treating ophthalmic diseases. Image, graphical abstract [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
45. IMMUNOGLOBULIN G4–RELATED OPHTHALMIC DISEASE MIMICKING INTRAOCULAR LYMPHOMA: A CASE REPORT
- Author
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Emanuela Aragona, Alessandro Arrigo, Alessandro Bordato, Giulio Modorati, Francesco Bandello, Elisabetta Miserocchi, and Alessandro Marchese
- Subjects
medicine.medical_specialty ,genetic structures ,medicine.diagnostic_test ,business.industry ,Lymph node biopsy ,Retinal ,General Medicine ,Fundus (eye) ,medicine.disease ,Fluorescein angiography ,eye diseases ,Ophthalmology ,chemistry.chemical_compound ,Choroiditis ,Optical coherence tomography ,chemistry ,Medicine ,sense organs ,Intraocular lymphoma ,Ophthalmic disease ,business - Abstract
Purpose To describe a case of IgG4-related choroiditis mimicking intraocular lymphoma. Methods The patient underwent a complete ophthalmological evaluation including multimodal imaging, with structural optical coherence tomography (OCT), fluorescein angiography (FA), indocyanine green angiography (ICGA), Ultra-Wide Field color and autofluorescent fundus photographies to assess the ocular involvement. Results Patient BCVA was of 20/25 in the right eye and 20/20 in the left eye. Fundus appearance showed abnormal yellowish choroidal lesions and moderate vitritis in both eyes . FA was within normal limits while ICGA showed areas of choroiditis in both eyes and structural OCT scans disclosed retinal small roundish lesions in the corresponding regions. Laboratory exams and lymph node biopsy led to the final diagnosis of IgG4-related disease. Conclusions We describe a case of IgG4-related choroiditis mimicking intraocular lymphoma. The proper use of multimodal imaging associated with laboratory investigations was useful to reach the correct diagnosis.
- Published
- 2022
46. Researchers from Chinese University of Hong Kong Detail New Studies and Findings in the Area of Ophthalmic Disease (Ocular Surface Evaluation In Immunoglobulin G4-related Ophthalmic Disease).
- Abstract
A recent study conducted by researchers from the Chinese University of Hong Kong examined the functional and structural changes in the meibomian glands and ocular surface in patients with immunoglobulin G4-related ophthalmic disease (IgG4-ROD). The study included 64 patients with biopsy-proven IgG4-ROD and compared them to age-matched healthy controls. The results showed that IgG4-ROD patients exhibited significant differences in various ocular surface parameters compared to healthy controls, suggesting features of both aqueous tear deficiency and evaporative dry eye disease. The researchers recommend ocular surface evaluation for all newly diagnosed IgG4-ROD patients. Further studies are needed to understand the mechanism of IgG4-related dry eye disease. [Extracted from the article]
- Published
- 2023
47. Study Results from Henan Eye Hospital Update Understanding of Ophthalmic Disease (Novel Role of Molecular Hydrogen: The End of Ophthalmic Diseases?).
- Abstract
A study conducted at Henan Eye Hospital in Zhengzhou, China, has explored the potential therapeutic effects of molecular hydrogen (H2) on ophthalmic diseases. H2 has been found to have protective and repairing effects on cells, reducing oxidative damage, inflammatory reactions, and apoptosis cascades. It has shown promise in the treatment of various ophthalmic diseases, including cataracts, dry eye disease, and diabetic retinopathy. However, further large-scale studies are needed to determine the optimal application mode and dosage of H2. The study provides an overview of H2's characteristics, its therapeutic effects, and the latest progress in administration approaches and mechanisms. [Extracted from the article]
- Published
- 2023
48. Patent Issued for Methods for the treatment of diabetic retinopathy and other ophthalmic diseases (USPTO 11795136).
- Subjects
DIABETIC retinopathy ,MACULAR degeneration ,VISION disorders ,RETROLENTAL fibroplasia ,DIABETES complications - Abstract
Acucela Inc. has been issued a patent for methods of treating diabetic retinopathy, retinopathy of prematurity, and wet age-related macular degeneration. Diabetic retinopathy is a common complication of diabetes and a leading cause of preventable blindness. Retinopathy of prematurity affects premature infants and can cause vision loss. Age-related macular degeneration is a major cause of severe visual loss in older individuals. The patent describes methods of administering visual cycle modulators to reduce energy demand in the retina and improve retinal function. The composition can be administered orally or locally to the eye. The patent claims a therapeutically effective daily dose of the composition. [Extracted from the article]
- Published
- 2023
49. Researchers from Kunming Describe Findings in Ophthalmic Disease (Progress in the diagnosis and treatment of immunoglobulin G4-related ophthalmic diseases).
- Abstract
Keywords for this news article include: Department of Ophthalmology, Kunming, People's Republic of China, Asia, Antineoplastics, Immunology, Epidemiology, Immunoproteins, Immunoglobulins, Serum Globulins, Ophthalmic Disease, Health and Medicine. Keywords: Antineoplastics; Epidemiology; Health and Medicine; Immunoglobulins; Immunology; Immunoproteins; Ophthalmic Disease; Proteins; Serum Globulins EN Antineoplastics Epidemiology Health and Medicine Immunoglobulins Immunology Immunoproteins Ophthalmic Disease Proteins Serum Globulins 2804 2804 1 11/06/23 20231110 NES 231110 2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- A new study on ophthalmic disease is now available. [Extracted from the article]
- Published
- 2023
50. Shandong University of Traditional Chinese Medicine Researchers Illuminate Research in Ophthalmic Disease (Role of DNA methylation in the pathogenesis of ophthalmic diseases).
- Abstract
Environment, Eye Diseases and Conditions, Health and Medicine, Ocular Disease, Ophthalmic Disease Keywords: Environment; Eye Diseases and Conditions; Health and Medicine; Ocular Disease; Ophthalmic Disease EN Environment Eye Diseases and Conditions Health and Medicine Ocular Disease Ophthalmic Disease 1953 1953 1 11/06/23 20231110 NES 231110 2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on ophthalmic disease. DNA methylation is an important part of epigenetic modification which is usually regulated by three processes: de novo methylation, maintenance methylation, and demethylation, and plays an essential role in regulating gene expression. [Extracted from the article]
- Published
- 2023
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