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5. Sham‐controlled randomized multicentre trial of transcranial direct current stimulation for prolonged disorders of consciousness.

Author

Thibaut, Aurore, Fregni, Felipe, Estraneo, Anna, Fiorenza, Salvatore, Noe, Enrique, Llorens, Roberto, Ferri, Joan, Formisano, Rita, Morone, Giovanni, Bender, Andreas, Rosenfelder, Martin, Lamberti, Gianfranco, Kodratyeva, Ekaterina, Kondratyev, Sergey, Legostaeva, Liudmila, Suponeva, Natalia, Krewer, Carmen, Müller, Friedemann, Dardenne, Nadia, and Jedidi, Haroun

Subjects
TRANSCRANIAL direct current stimulation, CONSCIOUSNESS disorders, PERSISTENT vegetative state
Abstract

Background and purpose: Transcranial direct current stimulation (tDCS) has been shown to improve signs of consciousness in a subset of patients with disorders of consciousness (DoC). However, no multicentre study confirmed its efficacy when applied during rehabilitation. In this randomized controlled double‐blind study, the effects of tDCS whilst patients were in rehabilitation were tested at the group level and according to their diagnosis and aetiology to better target DoC patients who might repond to tDCS. Methods: Patients received 2 mA tDCS or sham applied over the left prefrontal cortex for 4 weeks. Behavioural assessments were performed weekly and up to 3 months' follow‐up. Analyses were conducted at the group and subgroup levels based on the diagnosis (minimally conscious state [MCS] and unresponsive wakefulness syndrome) and the aetiology (traumatic or non‐traumatic). Interim analyses were planned to continue or stop the trial. Results: The trial was stopped for futility when 62 patients from 10 centres were enrolled (44 ± 14 years, 37 ± 24.5 weeks post‐injury, 18 women, 32 MCS, 39 non‐traumatic). Whilst, at the group level, no treatment effect was found, the subgroup analyses at 3 months' follow‐up revealed a significant improvement for patients in MCS and with traumatic aetiology. Conclusions: Transcranial direct current stimulation during rehabilitation does not seem to enhance patients' recovery. However, diagnosis and aetiology appear to be important factors leading to a response to the treatment. These findings bring novel insights into possible cortical plasticity changes in DoC patients given these differential results according to the subgroups of patients. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Clinical Validation of a Virtual Environment Test for Safe Street Crossing in the Assessment of Acquired Brain Injury Patients with and without Neglect

Author

Mesa-Gresa, Patricia, Lozano, Jose A., Llórens, Roberto, Alcañiz, Mariano, Navarro, María Dolores, Noé, Enrique, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Campos, Pedro, editor, Graham, Nicholas, editor, Jorge, Joaquim, editor, Nunes, Nuno, editor, Palanque, Philippe, editor, and Winckler, Marco, editor

Published
2011
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8. Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis

Author

Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris

Abstract

Background: Stroke rehabilitation interventions are routinely personalized to address individuals' needs, goals, and challenges based on evidence from aggregated randomized controlled trials (RCT) data and meta-syntheses. Individual participant data (IPD) meta-analyses may better inform the development of precision rehabilitation approaches, quantifying treatment responses while adjusting for confounders and reducing ecological bias. Aim: We explored associations between speech and language therapy (SLT) interventions frequency (days/week), intensity (h/week), and dosage (total SLT-hours) and language outcomes for different age, sex, aphasia severity, and chronicity subgroups by undertaking prespecified subgroup network meta-analyses of the RELEASE database. Methods: MEDLINE, EMBASE, and trial registrations were systematically searched (inception-Sept2015) for RCTs, including > 10 IPD on stroke-related aphasia. We extracted demographic, stroke, aphasia, SLT, and risk of bias data. Overall-language ability, auditory comprehension, and functional communication outcomes were standardized. A one-stage, random effects, network meta-analysis approach filtered IPD into a single optimal model, examining SLT regimen and language recovery from baseline to first post-intervention follow-up, adjusting for covariates identified a-priori. Data were dichotomized by age (<=/> 65 years), aphasia severity (mild-moderate/ moderate-severe based on language outcomes' median value), chronicity (<=/> 3 months), and sex subgroups. We reported estimates of means and 95% confidence intervals. Where relative variance was high (> 50%), results were reported for completeness. Results: 959 IPD (25 RCTs) were analyzed. For working-age participants, greatest language gains from baseline occurred alongside moderate to high-intensity SLT (functional communication 3-to-4 h/week; overall-language and comprehension > 9 h/week); older participants' greatest gains occurred alongside low-intensity SLT (<=

Published
2022

9. Dosage, Intensity, and Frequency of Language Therapy for Aphasia: A Systematic Review-Based, Individual Participant Data Network Meta-Analysis

Author

Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Branden-burg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, MaviS, ilknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaf-larski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Branden-burg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, MaviS, ilknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaf-larski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris

Abstract

BACKGROUND AND PURPOSE: Optimizing speech and language therapy (SLT) regimens for maximal aphasia recovery is a clinical research priority. We examined associations between SLT intensity (hours/week), dosage (total hours), frequency (days/week), duration (weeks), delivery (face to face, computer supported, individual tailoring, and home practice), content, and language outcomes for people with aphasia. METHODS: Databases including MEDLINE and Embase were searched (inception to September 2015). Published, unpublished, and emerging trials including SLT and >= 10 individual participant data on aphasia, language outcomes, and time post-onset were selected. Patient-level data on stroke, language, SLT, and trial risk of bias were independently extracted. Outcome measurement scores were standardized. A statistical inferencing, one-stage, random effects, network meta-analysis approach filtered individual participant data into an optimal model examining SLT regimen for overall language, auditory comprehension, naming, and functional communication pre-post intervention gains, adjusting for a priori-defined covariates (age, sex, time poststroke, and baseline aphasia severity), reporting estimates of mean change scores (95% CI). RESULTS: Data from 959 individual participant data (25 trials) were included. Greatest gains in overall language and comprehension were associated with >20 to 50 hours SLT dosage (18.37 [10.58-26.16] Western Aphasia Battery-Aphasia Quotient; 5.23 [1.51-8.95] Aachen Aphasia Test-Token Test). Greatest clinical overall language, functional communication, and comprehension gains were associated with 2 to 4 and 9+ SLT hours/week. Greatest clinical gains were associated with frequent SLT for overall language, functional communication (3-5+ days/week), and comprehension (4-5 days/week). Evidence of comprehension gains was absent for SLT <= 20 hours, <3 hours/week, and <= 3 days/week. Mixed receptive-expressive therapy, functionally tailored, with prescribed ho

Published
2022

11. Risk factors for 2-year mortality in patients with prolonged disorders of consciousness: An international multicentre study

Author

Estraneo, Anna Magliacano, Alfonso Fiorenza, Salvatore and Formisano, Rita Grippo, Antonello Angelakis, Efthymios and Cassol, Helena Thibaut, Aurore Gosseries, Olivia Lamberti, Gianfranco Noe, Enrique Bagnato, Sergio Edlow, Brian L. and Chatelle, Camille Lejeune, Nicolas Veeramuthu, Vigneswaran and Bartolo, Michelangelo Mattia, Donatella Toppi, Jlenia and Zasler, Nathan Schnakers, Caroline Trojano, Luigi

Abstract

Background and purpose Patients with prolonged disorders of consciousness (pDoC) have a high mortality rate due to medical complications. Because an accurate prognosis is essential for decision-making on patients’ management, we analysed data from an international multicentre prospective cohort study to evaluate 2-year mortality rate and bedside predictors of mortality. Methods We enrolled adult patients in prolonged vegetative state/unresponsive wakefulness syndrome (VS/UWS) or minimally conscious state (MCS) after traumatic and nontraumatic brain injury within 3 months postinjury. At enrolment, we collected demographic (age, sex), anamnestic (aetiology, time postinjury), clinical (Coma Recovery Scale-Revised [CRS-R], Disability Rating Scale, Nociception Coma Scale-Revised), and neurophysiologic (electroencephalogram [EEG], somatosensory evoked and event-related potentials) data. Patients were followed up to gather data on mortality up to 24 months postinjury. Results Among 143 traumatic (n = 55) and nontraumatic (n = 88) patients (VS/UWS, n = 68, 19 females; MCS, n = 75, 22 females), 41 (28.7%) died within 24 months postinjury. Mortality rate was higher in VS/UWS (42.6%) than in MCS (16%; p < 0.001). Multivariate regression in VS/UWS showed that significant predictors of mortality were older age and lower CRS-R total score, whereas in MCS female sex and absence of alpha rhythm on EEG at study entry were significant predictors. Conclusions This study demonstrated that a feasible multimodal assessment in the postacute phase can help clinicians to identify patients with pDoC at higher risk of mortality within 24 months after brain injury. This evidence can help clinicians and patients’ families to navigate the complex clinical decision-making process and promote an international standardization of prognostic procedures for patients with pDoC.

Published
2022

12. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke

Author

WILLIAMS, Louise R., ALI, Myzoon, VANDENBERG, Kathryn, WILLIAMS, Linda J., ABO, Masahiro, BECKER, Frank, BOWEN, Audrey, BRANDENBURG, Caitlin, BREITENSTEIN, Caterina, BRUEHL, Stefanie, COPLAND, David A., CRANFILL, Tamara B., DI PIETRO-BACHMANN, Marie, ENDERBY, Pamela, FILLINGHAM, Joanne, GALLI, Federica Lucia, GANDOLFI, Marialuisa, GLIZE, Bertrand, GODECKE, Erin, HAWKINS, Neil, HILARI, Katerina, HINCKLEY, Jacqueline, HORTON, Simon, HOWARD, David, JAECKS, Petra, JEFFERIES, Elizabeth, JESUS, Luis M. T., KAMBANAROS, Maria, KANG, Eun Kyoung, KHEDR, Eman M., KONG, Anthony Pak-Hin, KUKKONEN, Tarja, LAGANARO, Marina, RALPH, Matthew A. Lambon, LASKA, Ann Charlotte, LEEMANN, Beatrice, LEFF, Alexander P., LIMA, Roxele Ribeiro, LORENZ, Antje, MACWHINNEY, Brian, MARSHALL, Rebecca Shisler, MATTIOLI, Flavia, MAVIS, Iiknur, MEINZER, Marcus, NILIPOUR, Reza, NOE, Enrique, PAIK, Nam Jong, PALMER, Rebecca, PAPATHANASIOU, Ilias, PATRICIO, Brigida F., MARTINS, Isabel Pavao, PRICE, Cathy, JAKOVAC, Tatjana Prizl, ROCHON, Elizabeth, ROSE, Miranda L., ROSSO, Charlotte, RUBI-FESSEN, Ilona, RUITER, Marina B., SNELL, Claerwen, STAHL, Benjamin, SZAFLARSKI, Jerzy P., THOMAS, Shirley A., VAN DE SANDT-KOENDERMAN, Mieke, VAN DER MEULEN, Ineke, VISCH-BRINK, Evy, WORRALL, Linda, WRIGHT, Heather Harris, BRADY, Marian C., COLLABORATORS, RELEASE, Tampere University, Department of Neurosciences and Rehabilitation, Welfare Sciences, Repositório Científico do Instituto Politécnico do Porto, Rehabilitation Medicine, Neurology, and Neurosurgery

Subjects
FOS: Computer and information sciences, Linguistics and Language, 515 Psychology, 110321 Rehabilitation and Therapy (excl. Physiotherapy), Rehabilitation reporting standards, Big data, Psychological intervention, Context (language use), computer.software_genre, Medical and Health Sciences, Language and Linguistics, 3124 Neurology and psychiatry, law.invention, Language and Speech, Learning and Therapy, speech and language, Randomized controlled trial, 80604 Database Management, law, Aphasia, Health Sciences, Developmental and Educational Psychology, medicine, Stroke, therapy, Modalities, Database, business.industry, Clinical study design, FOS: Clinical medicine, Individual participant data, individual participant data, rehabilitation reporting standards, Speech and language therapy, LPN and LVN, medicine.disease, aphasia, Language & Communication, P1, Neurology, Otorhinolaryngology, Neurology (clinical), RG, medicine.symptom, business, Psychology, computer
Abstract

Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated.\ud \ud \ud \ud Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned aphasia research analyses.\ud \ud \ud \ud Methods: Data were collated by systematically identifying existing, eligible studies in any language (≥10 IPD, data on time since stroke, and language performance) and included sourcing from relevant aphasia research networks. We invited electronic contributions and also extracted IPD from the public domain. Data were assessed for completeness, validity of value-ranges within variables, and described according to pre-defined categories of demographic data, therapy descriptions, and language domain measurements. We cleaned, clarified, imputed and standardised relevant data in collaboration with the original study investigators. We presented participant, language, stroke, and therapy data characteristics of the final database using summary statistics.\ud \ud \ud \ud Results: From 5256 screened records, 698 datasets were potentially eligible for inclusion; 174 datasets (5928 IPD) from 28 countries were included, 47/174 RCT datasets (1778 IPD) and 91/174 (2834 IPD) included a speech and language therapy (SLT) intervention. Participants’ median age was 63 years (interquartile range [53, 72]), 3407 (61.4%) were male and median recruitment time was 321 days (IQR 30, 1156) after stroke. IPD were available for aphasia severity or ability overall (n = 2699; 80 datasets), naming (n = 2886; 75 datasets), auditory comprehension (n = 2750; 71 datasets), functional communication (n = 1591; 29 datasets), reading (n = 770; 12 datasets) and writing (n = 724; 13 datasets). Information on SLT interventions were described by theoretical approach, therapy target, mode of delivery, setting and provider. Therapy regimen was described according to intensity (1882 IPD; 60 datasets), frequency (2057 IPD; 66 datasets), duration (1960 IPD; 64 datasets) and dosage (1978 IPD; 62 datasets).\ud \ud \ud \ud Discussion: Our international IPD archive demonstrates the application of big data principles in the context of aphasia research; our rigorous methodology for data acquisition and cleaning can serve as a template for the establishment of similar databases in other research areas.

Published
2022
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13. International prospective study on long-term clinical evolution of patients with severe brain injury and disorders of consciousness

Author

Estraneo, Anna, Magliacano, Alfonso, Fiorenza, Salvatore, Formisano, Rita, Grippo, Antonello, Angelakis, Efthymios, Cassol, Helena, Thibaut, Aurore, Gosseries, Olivia, Lamberti, Gianfranco, Noé, Enrique, Bagnato, Sergio, Edlow, Brian, Lejeune, Nicolas, Veeramuthu, Vigneswaran, Bartolo, Michelangelo, De Bellis, Francesco, Catino, Francesco, Mattia, Donatella, Toppi, Jlenia, Zasler, Nathan, Schnakers, Caroline, and Trojano, Luigi

Published
2021
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14. International prospective study on long-term clinical evolution of patients with severe brain injury and disorders of consciousness

Author

Estraneo, Anna Magliacano, Alfonso Fiorenza, Salvatore and Formisano, Rita Grippo, Antonello Angelakis, Efthymios and Cassol, Helena Thibaut, Aurore Gosseries, Olivia Lamberti, Gianfranco Noe, Enrique Bagnato, Sergio Edlow, Brian and Lejeune, Nicolas Veeramuthu, Vigneswaran Bartolo, Michelangelo and De Bellis, Francesco Catino, Francesco Mattia, Donatella and Toppi, Jlenia Zasler, Nathan Schnakers, Caroline Trojano, Luigi

Published
2021

15. Predictors of Poststroke Aphasia Recovery A Systematic Review-Informed Individual Participant Data Meta-Analysis

Author

Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Mac Whinney, Brian, Marshall, Rebecca Shisler, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Mac Whinney, Brian, Marshall, Rebecca Shisler, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, and Brady, Marian C.

Abstract

Background and Purpose: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants' age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. Results: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4-165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3-26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0-20.9], +6.1 correct on AAT Token Test [CI, 3.2-8.9]; +9.3 Boston Naming Test points [CI, 4.7-13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5-1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9-24.4]; +5.3 correct on AAT Token Test [CI, 1.7-8.8]; +11.1 Boston Naming Test points [CI, 5.7-16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7-1.4]) conferred the greatest absolute change-from-baseline across each language doma

Published
2021

16. Calidad de servicio y satisfacción de los usuarios en la asistencia técnica de la CONECTAMEF en el año 2019

Author

García Chihuan, Henrry William, García Chihuan, Noe Enrique, and Mory Chiparra, William Eduardo

Subjects
situated learning, oportunidad del apoyo, Calidad de servicio, negocio, Information and communication technologies
Abstract

La búsqueda de calidad ha ido ganando protagonismo en las organizaciones. La asistencia al público, así como sus características e importancia es algo que ha recibido mucha atención por parte de las empresas, considerando que la calidad es el resultado de un trabajo bien ejecutado y esto repercute en la satisfacción del usuario. Por lo cual se plantea probar la hipótesis. Para probar la hipótesis propuesta se hiso uso del método cuantitativo con un diseño descriptivo correlacional. La calidad de servicio tiene una relación positiva con la satisfacción del usuario de asistencia técnica de la CONECTAMEF en el año 2019, después de realizar la pesquisas necesarias y procesar los datos se obtuvo una Rho de Spearman de 0.929 considerada una relación muy alta; lo que permitió concluir que existe una relación muy fuerte entre ambas variables, por eso podemos asegurar que si se utilizan de manera adecuada la calidad de servicio la satisfacción del usuario mejorara en la Universidad. Increasingly, the so-called "new technologies" are present in people's daily lives and are producing unexpected changes in today's society in all spheres of the social, political, economic, legal and social structure. This evolution of Information and Communication Technologies (ICT) allows the majority of the population to have access to information, which brings profound changes in various areas of knowledge, especially in the academic field, where knowledge is discussed and constructed.. Therefore, the research was born to test the following working hypothesis: The better uses of information and communication technologies (ICT), the better the learning located in law students of the National University of Huancavelica in the year 2019. To test the proposed hypothesis, the quantitative method was used with a descriptive correlational design. The information and communication technologies have a significant relationship with the learning located in the law students of the National University of Huancavelica in the year 2019, after conducting the necessary research and processing the data, a Spearman Rho of 0.929 considered was obtained a very high relationship; This allowed us to conclude that there is a very strong relationship between both variables, so we can ensure that if information and communication technologies are used properly, the learning located will improve in the University. Tesis

Published
2020

17. RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Author

Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Whinney, Brian Mac, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, İlknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, Van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris

Subjects
Stroke, IPD, Meta-analysis, Complex intervention, Aphasia, Clinical Medicine, Medical and Health Sciences
Abstract

Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions. Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains. Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947)

Published
2020

18. Prefrontal Transcranial Direct Current Stimulation in Patients with Disorders of Consciousness: A Multicentre, Randomised, Double-Blind, Sham-Controlled Clinical Trial

Author

Thibaut, Aurore, primary, Estraneo, Anna, additional, Fiorenza, Salvatore, additional, Noe, Enrique, additional, Llorens, Roberto, additional, Ferri, Joan, additional, Formisano, Rita, additional, Morone, Giovanni, additional, Bender, Andreas, additional, Rosenfelder, Martin, additional, Lamberti, Gianfranco, additional, Kodratyeva, Ekaterina, additional, Kondratyev, Sergey, additional, Legostaeva, Liudmila, additional, Krewer, Carmen, additional, Müller, Friedemann, additional, Dardenne, Nadia, additional, Jedidi, Haroun, additional, Laureys, Steven, additional, Gosseries, Olivia, additional, Fregni, Felipe, additional, Lejeune, Nicolas, additional, and Martens, Géraldine, additional

Published
2021
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24. Posturography using the Wii Balance Board. A feasibility study with healthy adults and adults post-stroke

Author

Llorens Rodríguez, Roberto, Grau Latorre, Jorge, Noe, Enrique, and Keshner, Emily A.

Subjects
Stroke, EXPRESION GRAFICA EN LA INGENIERIA, Posturography, Balance assessment, Feasibility, Wii Balance Board
Abstract

[EN] Background: Posturography systems that incorporate force platforms are considered to assess balance and postural control with greater sensitivity and objectivity than conventional clinical tests. The Wii Balance Board (WBB) system has been shown to have similar performance characteristics as other force platforms, but with lower cost and size. Objectives: To determine the validity and reliability of a freely available WBB-based posturography system that combined the WBB with several traditional balance assessments, and to assess the performance of a cohort of stroke individuals with respect to healthy individuals. Methods: Healthy subjects and individuals with stroke were recruited. Both groups were assessed using the WBB-based posturography system. Individuals with stroke were also assessed using a laboratory grade posturography system and a battery of clinical tests to determine the concurrent validity of the system. A group of subjects were assessed twice with the WBB-based system to determine its reliability. Results: A total of 144 healthy individuals and 53 individuals with stroke participated in the study. Concurrent validity with another posturography system was moderate to high. Correlations with clinical scales were consistent with previous research. The reliability of the system was excellent in almost all measures. In addition, the system successfully characterized individuals with stroke with respect to the healthy population. Conclusions: The WBB-based posturography system exhibited excellent psychometric properties and sensitivity for identifying balance performance of individuals with stroke in comparison with healthy subjects, which supports feasibility of the system as a clinical tool. (C) 2015 Elsevier B.V. All rights reserved., This study was funded by project NeuroVR (TIN2013-44741-R) of the Ministerio de Economia y Competitividad (Madrid, Spain).

Published
2015
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25. Mirror therapy in chronic stroke survivors with severely impaired upper limb function: a randomized controlled trial

Author

Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Ministerio de Economía y Competitividad, Universitat Politècnica de València, Colomer, Carolina, Noe, Enrique, Llorens Rodríguez, Roberto, Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Ministerio de Economía y Competitividad, Universitat Politècnica de València, Colomer, Carolina, Noe, Enrique, and Llorens Rodríguez, Roberto

Abstract

[EN] BACKGROUND: Mirror therapy (MT) has been proposed to improve the motor function of chronic individuals with stroke with mild to moderate impairment. With regards to severe upper limb paresis, MT has shown to provide limited motor improvement in the acute or sub-acute phase. However, no previous research has described the effects of MT in chronic individuals with stroke with severely impaired upper limb function. AIM: The aim of this study was to determine the effectiveness of MT on chronic stroke survivors with severe upper-limb impairment in comparison with passive mobilization. DESIGN: A randomized controlled trial. SETTING: Rehabilitative outpatient unit. POPULATION: A total of 31 chronic subjects poststroke with severely impaired upper limb function were randomly assigned to either an experimental group (N.=15), or a control group (N.=16). METHODS: Twenty-four intervention sessions were performed for both groups. Each session included 45-minute period of MT (experimental group) or passive mobilization (control group), administered three days a week. Participants were assessed before and after the intervention with the Wolf Motor Function Test, the Fugl-Meyer Assessment, and the Nottingham Sensory Assessment. RESULTS: Improvement in motor function was observed in both groups on the time (P=0.002) and ability (P=0.001) subscales of the Wolf Motor Function Test. No differences were detected in kinesthesis or stereognosis. However, the experimental group showed a significant improvement in tactile sensation that was mainly observed as an increased sensitivity to light touches. CONCLUSIONS: In comparison with passive mobilization, MT in chronic stroke survivors with severely impaired upper-limb function may provide a limited but positive effect on light touch sensitivity while providing similar motor improvement. CLINICAL REHABILITATION IMPACT: MT is a therapeutic approach that can be used in the rehabilitation of severely impaired upper limb in chronic stroke s

Published
2016

26. Through the Eyes of Neglect Patients: A Preliminary Eye-Tracking Study of Unilateral Spatial Neglect

Author

Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Llorens Rodríguez, Roberto, Noe, Enrique, Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Llorens Rodríguez, Roberto, and Noe, Enrique

Published
2016

27. The Spanish version of the coma recovery scale-revised: Events on a correct timeline

Author

Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Ferri, Joan, Noe, Enrique, Llorens Rodríguez, Roberto, Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Ferri, Joan, Noe, Enrique, and Llorens Rodríguez, Roberto

Published
2015

28. Posturography using the Wii Balance Board. A feasibility study with healthy adults and adults post-stroke

Author

Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Ministerio de Economía y Competitividad, Llorens Rodríguez, Roberto, Grau Latorre, Jorge, Noe, Enrique, Keshner, Emily A., Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Ministerio de Economía y Competitividad, Llorens Rodríguez, Roberto, Grau Latorre, Jorge, Noe, Enrique, and Keshner, Emily A.

Abstract

[EN] Background: Posturography systems that incorporate force platforms are considered to assess balance and postural control with greater sensitivity and objectivity than conventional clinical tests. The Wii Balance Board (WBB) system has been shown to have similar performance characteristics as other force platforms, but with lower cost and size. Objectives: To determine the validity and reliability of a freely available WBB-based posturography system that combined the WBB with several traditional balance assessments, and to assess the performance of a cohort of stroke individuals with respect to healthy individuals. Methods: Healthy subjects and individuals with stroke were recruited. Both groups were assessed using the WBB-based posturography system. Individuals with stroke were also assessed using a laboratory grade posturography system and a battery of clinical tests to determine the concurrent validity of the system. A group of subjects were assessed twice with the WBB-based system to determine its reliability. Results: A total of 144 healthy individuals and 53 individuals with stroke participated in the study. Concurrent validity with another posturography system was moderate to high. Correlations with clinical scales were consistent with previous research. The reliability of the system was excellent in almost all measures. In addition, the system successfully characterized individuals with stroke with respect to the healthy population. Conclusions: The WBB-based posturography system exhibited excellent psychometric properties and sensitivity for identifying balance performance of individuals with stroke in comparison with healthy subjects, which supports feasibility of the system as a clinical tool. (C) 2015 Elsevier B.V. All rights reserved.

Published
2015

29. Effectiveness, usability, and cost-benefit of a virtual reality-based telerehabilitation program for balance recovery after stroke: a randomized controlled trial

Author

Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Universitat Politècnica de València. Departamento de Ingeniería Gráfica - Departament d'Enginyeria Gràfica, Ministerio de Ciencia e Innovación, Generalitat Valenciana, Ministerio de Educación y Ciencia, Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, Llorens Rodríguez, Roberto, Noe, Enrique, Colomer, Carolina, Alcañiz Raya, Mariano Luis, Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Universitat Politècnica de València. Departamento de Ingeniería Gráfica - Departament d'Enginyeria Gràfica, Ministerio de Ciencia e Innovación, Generalitat Valenciana, Ministerio de Educación y Ciencia, Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, Llorens Rodríguez, Roberto, Noe, Enrique, Colomer, Carolina, and Alcañiz Raya, Mariano Luis

Abstract

[EN] Objectives: First, to evaluate the clinical effectiveness of a virtual reality (VR) based telerehabilitation program in the balance recovery of individuals with hemiparesis after stroke in comparison with an in-clinic program; second, to compare the subjective experiences; and third, to contrast the costs of both programs. Design: Single-blind, randomized, controlled trial. Setting: Neurorehabilitation unit. Participants: Chronic outpatients with stroke (N=30) with residual hemiparesis. Interventions: Twenty 45-minute training sessions with the telerehabilitation system, conducted 3 times a week, in the clinic or in the home. Main Outcome Measures: First, Berg Balance Scale for balance assessment. The Performance-Oriented Mobility Assessment balance and gait sub-scales, and the Brunel Balance Assessment were secondary outcome measures. Clinical assessments were conducted at baseline, 8 weeks (posttreatment), and 12 weeks (follow-up). Second, the System Usability Scale and the Intrinsic Motivation Inventory for subjective experiences. Third, cost (in dollars). Results: Significant improvement in both groups (in-clinic group [control] and a home-based telerehabilitation group) from the initial to the final assessment in the Berg Balance Scale (eta(2)(p) = .68; P=.001), in the balance (eta(2)(p) = .24; P=.006) and gait (eta(2)(p) =.57, P=.001) subscales of the Tinetti Performance-Oriented Mobility Assessment, and in the Brunel Balance Assessment (control: chi(2)=15.0; P=.002; experimental: chi(2)=21.9; P=.001). No significant differences were found between the groups in any balance scale or in the feedback questionnaires. With regard to subjective experiences, both groups considered the VR system similarly usable and motivating. The in-clinic intervention resulted in more expenses than did the telerehabilitation intervention ($654.72 per person). Conclusions: First, VR-based telerehabilitation interventions can promote the reacquisition of locomotor skills associa

Published
2015

30. Effectiveness of a virtual board game to improve self-awareness in acquired brain injury patients

Author

Noe, Enrique, Llorens Rodríguez, Roberto, Ferri Campos, Joan, and Alcañiz Raya, Mariano Luis

Subjects
EXPRESION GRAFICA EN LA INGENIERIA, human activities
Abstract

Acquired brain injury (ABI) is a complex disease that involves impairment in motor and cognitive skills and in psychological functions, including the self-awareness. An alteration of this capacity slows the rehabilitation progress and represents one of the greatest impediments to social integration and optimal adjustment. The objective of this study is to study the effectiveness of a therapeutic and recreational virtual game board to rehabilitate selfawareness deficits following ABI

Published
2013

31. Balance rehabilitation through virtual reality: a randomized controlled trial with acquired brain injury patients

Author

Llorens Rodríguez, Roberto, Noe, Enrique, Colomer Font, Carolina, and Alcañiz Raya, Mariano Luis

Subjects
EXPRESION GRAFICA EN LA INGENIERIA
Abstract

In the last years, the potential benefits of virtual reality in the rehabilitation process have been highlighted by several studies. This fact has given rise to a great number of virtual rehabilitation systems. However, just a few focus on balance rehabilitation, although it is one of the most disabling impairments. The objective of this study is to validate the balance recovery exercises of a virtual rehabilitation system (BioTrak) in acquired brain injury (ABI) patients.

Published
2013
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34. Effectiveness of a virtual board game to improve self-awareness in acquired brain injury patients

Author

Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Universitat Politècnica de València. Departamento de Ingeniería Gráfica - Departament d'Enginyeria Gràfica, Noe, Enrique, Llorens Rodríguez, Roberto, Ferri Campos, Joan, Alcañiz Raya, Mariano Luis, Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Universitat Politècnica de València. Departamento de Ingeniería Gráfica - Departament d'Enginyeria Gràfica, Noe, Enrique, Llorens Rodríguez, Roberto, Ferri Campos, Joan, and Alcañiz Raya, Mariano Luis

Abstract

Acquired brain injury (ABI) is a complex disease that involves impairment in motor and cognitive skills and in psychological functions, including the self-awareness. An alteration of this capacity slows the rehabilitation progress and represents one of the greatest impediments to social integration and optimal adjustment. The objective of this study is to study the effectiveness of a therapeutic and recreational virtual game board to rehabilitate selfawareness deficits following ABI

Published
2013

35. Balance rehabilitation through virtual reality: a randomized controlled trial with acquired brain injury patients

Author

Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Universitat Politècnica de València. Departamento de Ingeniería Gráfica - Departament d'Enginyeria Gràfica, Llorens Rodríguez, Roberto, Noe, Enrique, Colomer Font, Carolina, Alcañiz Raya, Mariano Luis, Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Universitat Politècnica de València. Departamento de Ingeniería Gráfica - Departament d'Enginyeria Gràfica, Llorens Rodríguez, Roberto, Noe, Enrique, Colomer Font, Carolina, and Alcañiz Raya, Mariano Luis

Abstract

In the last years, the potential benefits of virtual reality in the rehabilitation process have been highlighted by several studies. This fact has given rise to a great number of virtual rehabilitation systems. However, just a few focus on balance rehabilitation, although it is one of the most disabling impairments. The objective of this study is to validate the balance recovery exercises of a virtual rehabilitation system (BioTrak) in acquired brain injury (ABI) patients.

Published
2013

36. Therapeutic effectiveness of a virtual reality game in self-awareness after acquired brain injury

Author

Wiederhold, Brenda K., Riva, Giuseppe, Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Universitat Politècnica de València. Departamento de Ingeniería Gráfica - Departament d'Enginyeria Gràfica, Ministerio de Educación y Ciencia, Generalitat Valenciana, Llorens Rodríguez, Roberto, Navarro Pérez, María Dolores, Alcañiz Raya, Mariano Luis, Noe, Enrique, Wiederhold, Brenda K., Riva, Giuseppe, Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà, Universitat Politècnica de València. Departamento de Ingeniería Gráfica - Departament d'Enginyeria Gràfica, Ministerio de Educación y Ciencia, Generalitat Valenciana, Llorens Rodríguez, Roberto, Navarro Pérez, María Dolores, Alcañiz Raya, Mariano Luis, and Noe, Enrique

Abstract

© 2012 Interactive Media Institute and IOS Press., [EN] Self-awareness deficits can manifest as a consequence of acquired brain injury decreasing the motivation and the adherence to the treatment. We present a multitouch system that promotes the role-playing and the self-assessment strategies and challenges the participants in a competitive context. This paper presents an initial clinical trial to study the effectiveness of the virtual system in the rehabilitation of the self-awareness skills. According the evolution of the participants in the Self-Awareness Deficits Interview and in the Spanish Social Skills Scale, the participants improve the perception of their deficits and disabilities.

Published
2012

38. BioTrak: a comprehensive overview

Author

Llorens, Roberto, primary, Gil-Gomez, Jose-Antonio, additional, Mesa-Gresa, Patricia, additional, Alcaniz, Mariano, additional, Colomer, Carolina, additional, and Noe, Enrique, additional

Published
2011
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41. Clinical and Neurophysiological Prognostic Markers for Short-Term Outcome in Prolonged Disorders of Consciousness: A Multi-Center Longitudinal Study of the IBIA-Disorders of Consciousness-Special Interest Group

Author

Fiorenza, Salvatore, Magliacano, Alfonso, Grippo, Antonello, Romoli, Anna Maria, Formisano, Rita, Mattia, Donatella, Efthymios, Angelakis, Cassol, Helena, Thibaut, Aurore, Gosseries, Olivia, Noe, Enrique, Lamberti, Gianfranco, Sergio Bagnato, Edlow, Brian, Chatelle, Camille, Lejeune, Nicolas, Bartolo, Michelangelo, Veeramuthu, Vigneswaran, Trojano, Luigi, Toppi, Jlenia, Blandiaux, Severine, Masotta, Orsola, Zasler, Nathan, Schnakers, Caroline, and Estraneo, Anna

42. Therapeutic effectiveness of a virtual reality game in self-awareness after acquired brain injury

Author

Llorens Rodríguez, Roberto, Navarro Pérez, María Dolores, Alcañiz Raya, Mariano Luis, and Noe, Enrique

Subjects
Adult, Male, Motivation, EXPRESION GRAFICA EN LA INGENIERIA, Virtual rehabilitation, Awareness, User-Computer Interface, Treatment Outcome, Video Games, Brain Injuries, Therapy, Computer-Assisted, Neurorehabilitation, Acquired brain injury, Humans, Patient Compliance, Female
Abstract

[EN] Self-awareness deficits can manifest as a consequence of acquired brain injury decreasing the motivation and the adherence to the treatment. We present a multitouch system that promotes the role-playing and the self-assessment strategies and challenges the participants in a competitive context. This paper presents an initial clinical trial to study the effectiveness of the virtual system in the rehabilitation of the self-awareness skills. According the evolution of the participants in the Self-Awareness Deficits Interview and in the Spanish Social Skills Scale, the participants improve the perception of their deficits and disabilities., This study was funded in part by Ministerio de Educación y Ciencia Spain, Projects Consolider-C (SEJ2006- 14301/PSIC), “CIBER of Physiopathology of Obesity and Nutrition, an initiative of ISCIII” and the Excellence Research Program PROMETEO (Generalitat Valenciana. Conselleria de Educación, 2008-157).

43. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke

Author

Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele Ribeiro, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Iiknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, Van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele Ribeiro, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Iiknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, Van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, and Brady, Marian C.

Abstract

Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned aphasia research analyses. Methods: Data were collated by systematically identifying existing, eligible studies in any language (>= 10 IPD, data on time since stroke, and language performance) and included sourcing from relevant aphasia research networks. We invited electronic contributions and also extracted IPD from the public domain. Data were assessed for completeness, validity of value-ranges within variables, and described according to pre-defined categories of demographic data, therapy descriptions, and language domain measurements. We cleaned, clarified, imputed and standardised relevant data in collaboration with the original study investigators. We presented participant, language, stroke, and therapy data characteristics of the final database using summary statistics. Results: From 5256 screened records, 698 datasets were potentially eligible for inclusion; 174 datasets (5928 IPD) from 28 countries were included, 47/174 RCT datasets (1778 IPD) and 91/174 (2834 IPD) included a speech and language therapy (SLT) intervention. Participants' median age was 63 years (interquartile range [53, 72]), 3407 (61.4%) were male and median recruitment time was 321 days (IQR 30, 1156) after stroke. IPD were available for aphasia severity or ab

44. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke

Author

Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele Ribeiro, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Iiknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, Van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele Ribeiro, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Iiknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, Van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, and Brady, Marian C.

Abstract

Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned aphasia research analyses. Methods: Data were collated by systematically identifying existing, eligible studies in any language (>= 10 IPD, data on time since stroke, and language performance) and included sourcing from relevant aphasia research networks. We invited electronic contributions and also extracted IPD from the public domain. Data were assessed for completeness, validity of value-ranges within variables, and described according to pre-defined categories of demographic data, therapy descriptions, and language domain measurements. We cleaned, clarified, imputed and standardised relevant data in collaboration with the original study investigators. We presented participant, language, stroke, and therapy data characteristics of the final database using summary statistics. Results: From 5256 screened records, 698 datasets were potentially eligible for inclusion; 174 datasets (5928 IPD) from 28 countries were included, 47/174 RCT datasets (1778 IPD) and 91/174 (2834 IPD) included a speech and language therapy (SLT) intervention. Participants' median age was 63 years (interquartile range [53, 72]), 3407 (61.4%) were male and median recruitment time was 321 days (IQR 30, 1156) after stroke. IPD were available for aphasia severity or ab

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