166 results on '"Niels Fertig"'
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2. Functional characterization of SGLT1 using SSM-based electrophysiology: Kinetics of sugar binding and translocation
3. A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development
4. There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments
5. A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp
6. A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time
7. Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
8. An electrophysiological approach for low turnover and intracellular transport proteins: Improving amplification and accessibility
9. Pharmacology of P2X3 and P2X2/3 receptors: An automated patch clamp study
10. The suitability of high throughput automated patch clamp for physiological applications
11. Real-time monitoring β-lactam/β-lactamase inhibitor (BL/BLI) mixture towards the bacteria porin pathway at single molecule level
12. Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment
13. High-content multi-frequency impedance cell monitoring for label-free and time-resolved cell toxicity analysis of various cell types
14. A Scalable Approach Reveals Functional Responses of iPSC Cardiomyocyte 3D Spheroids
15. Identification of cardiac liability in drug discovery using automated patch clamp: experimental and technical considerations for high throughput recordings of NaV1.5 and hERG
16. Accessing intracellular membrane transport proteins: a novel electrophysiological approach for lysosomal and mitochondrial channels and transporters
17. SSM-based electrophysiology, a label-free real-time method reveals sugar binding & transport events in SGLT1
18. Tackling chronic compound responses of hiPSC-CMs for preclinical cardiac risk evaluation: defined serum-free medium and long-term culture on the FLEXcyte 96
19. Electrophysiology on Channel-Forming Proteins in Artificial Lipid Bilayers: Next-Generation Instrumentation for Multiple Recordings in Parallel
20. Electrophysiology on Channel-Forming Proteins in Artificial Lipid Bilayers: Next-Generation Instrumentation for Multiple Recordings in Parallel
21. Automated patch clamp in drug discovery: major breakthroughs and innovation in the last decade
22. Integration of mechanical conditioning into a high throughput contractility assay for cardiac safety assessment
23. Automated Dynamic Clamp for Simulation of I
24. Mechanical stimulation in a 2D high-throughput contractility system induces functional changes in human induced pluripotent stem cell-derived cardiomyocytes
25. Drug effects on human Na+/Ca2+ exchanger and implications for testing new drug candidates
26. High throughput chronic cardiotoxicity evaluation of human iPSC-derived cardiomyocytes in a pro-maturation environment
27. Reliable identification of heart disease in drug discovery using automated patch clamps: Benchmarking best practices and calibration criteria for improved proarrhythmic assessment
28. Cell monitoring using multi-frequency impedance recordings for label-free and time-resolved cell response analysis
29. The NaV1.5 late current in WT and Nav1.5-ΔKPQ mutant channels: An automated patch clamp LQT3 electrophysiological assay comparison
30. A Novel Approach to Detect Electrogenic Transporter Activity in Intact Cells Applied to Investigate IPSC Derived Cardiomyocytes and Neurons
31. Reliable Identification of hERG Liability in Drug Discovery by Automated Patch Clamp
32. Kinetic and Pharmacological Properties of P2X3 and P2X2/3 Receptors
33. Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module
34. Drug Effects On Human Na(+)/Ca(2+)Exchanger and Implications for Drug Development
35. Activation and Inhibition of Assay-Ready TRPA1 and TRPV Cells: An Automated Patch Clamp Study
36. Identification of Drug–Drug InteractionsIn Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on hiPSC-Derived Cardiomyocytes
37. Novel screening techniques for ion channel targeting drugs
38. Functional monitoring approaches for cardiac safety assessments and toxicity
39. A higher-throughput approach to investigate cardiac contractility in vitro under physiological mechanical conditions
40. Reliable identification of hERG liability in drug discovery by automated patch clamp
41. Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment
42. Automated patch clamp system introducing simulated Ik1 into human iPSC-cardiomycoytes using dynamic clamp
43. Combining Physiological Relevance and Throughput for in vitro Cardiac Contractility Measurement
44. Automated Patch Clamp System Introducing Simulated IK1 into Stem Cell-Derived Cardiomyocytes using Dynamic Clamp
45. A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time
46. An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery
47. A Novel Gain of Function Mutation of Piezo-1 is Investigated in Red Blood Cells by High-Throughput Patch Clamp
48. New Easy-to-Use Hybrid System for Extracellular Potential and Impedance Recordings
49. Antibiotic translocation through porins studied in planar lipid bilayers using parallel platforms
50. A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of I
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