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The establishment of chemical homogeneity is a critical goal in manufacturing drug substances and drug products, which are collectively referred to as pharmaceutical components. By contrast, manufacturers make no known [...]

Global and regional left ventricular performances were evaluated with equilibrium radionuclide angiocardiography in patients in the Thrombolysis in Myocardial Infarction (TIMI) II trial at the time of hospital discharge. Studies at rest were available in 1,162 (69%) of the invasive and 1,150 (69%) of the conservative strategy patients, and exercise studies in 1,133 (67%) of the invasive and 1,145 (69%) of the conservative patients. Repeat studies were performed at the time of 6-week follow-up. Global and regional ejection fraction at rest were both comparable in patients assigned to each of the treatment strategies. However, at the time of hospital discharge patients in the invasive strategy had normal exercise responses more frequently (29.7 vs 25.8% p = 0.01), greater peak exercise LV ejection fraction (54.8 [+ or -] 13.8% vs 53.1 [+ or -] 14.1%, p = 0.004), greater exercise - rest change in LV ejection fraction (3.7 [+ or -] 6.7% vs 2.7 [+ or -] 7.2%, p

Dr. Chez is Professor of Obstetrics and Gynecology, and Professor of Community Health and Family Health, University of South Florida, Tampa, Fla. John P. Elliott, MD, is a perinatologist who [...]

Harland Anderson, a Minnesota farmer and author of the 1995 US `freedom to farm' law, generated a lively debate when he spoke at an International Farmers' Dialogue in Minneapolis, last [...]

I want to say thanks for a quality magazine that is both informative and entertaining. My father forwards my magazines to me out here in Iraq. Reading BOWHUNTING lets me [...]

Secret Dreams: a biography of Michael Redgrave Alan Strachan Weidenfeld & Nicolson, 484pp, £25 The beginning of the end of Michael Redgrave's acting career came not on stage but in […]

Sunshine on Putty: the golden age of British comedy from Vic Reeves to The Office Ben Thompson Fourth Estate, 459pp, 15 £ In the town where I live an eccentric [...]

To gain insight into the altered kinetics of creatine kinase-MB (CK-MB) release after reperfusion, a physiologically based model with first-order CK-MB appearance and disappearance functions was postulated. This biexponential model is based on the assumption that reperfusion reestablishes nutritive blood flow, providing direct access of interstitial CK-MB to the bloodstream. This is in contrast to persistent coronary artery occlusion, in which no direct access to nutritive flow is present. The accuracy of this model was examined in 8 dogs reperfused after 2 hours of coronary artery occlusion. The fit to observed values was excellent, with a mean [r. sup.2] of 0.97 [+ or -] 0.05. In agreement with the biexponential model, the initial increase in CK-MB activity was abrupt and rapid. The same degree of accuracy was found in 21 patients with angiographic evidence of reperfusion after thrombolytic therapy (mean [r. sup.2] 0.97 [+ or -] 0.02). The appearance characteristics were similar to the animal model, with an abrupt and rapid increase in CK-MB activity. When compared with 5 patients with persistent occlusion, [k. sub.a], the rate constant of the appearance function, clearly distinguished patients with reperfusion (chi-square = 20.6, p

An example of an experiment that can be used to teach Year 10 science students about endothermic and exothermic reactions.

Michael Frayn's Democracy might well be this year's best play, but his lasting reputation as a dramatist rests on a far more serious work. No, I don't mean Copenhagen, but [...]

Take one retired cop with a bunch of nerve damage, one sorta-rare HK PSP squeeze-cocker pistol, and start searching for a good comfy shoulder holster. Go ahead. Good luck. What [...]

My first thought when I opened the box was, 'I'm the wrong guy for this.' I'm not picky about the oils and lubes I use on firearms, I'm nasty-hyper-critical, in [...]

Not content with his comfortable work at the University of Minnesota, Jesse Williams, emeritus professor of animal husbandry, decided to work in needy countries overseas. Over 25 years Williams worked [...]

The annual education conference of the American Hospital Assn's Healthcare Information and Management Systems Society will be held in Atlanta, GA in Mar 1996. More than 12,000 healthcare information managers are expected to be in attendance. The College of Healthcare Information Management Executives (CHIME) will hold its own chief information officer (CIO) forum just before the conference. CHIME focuses more on the overall impact of information technology rather than on technical issues, which is the focus of CIOs.

Toxic gases, smoke, and heat are no match for this tough coating A tough UV-curable clearcoat protects the lens in the facepiece of self-contained breathing apparatus (SCBA) for fire fighters. [...]