17 results on '"Mika Kawamura"'
Search Results
2. Supplementary Figure Legends 1-6 from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
- Author
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Shinya Watanabe, Kentaro Semba, Jun-ichiro Inoue, Kuniaki Tatsuta, Susumu Ohwada, Jun-ichi Imai, Mika Kawamura, Akira Nishikawa, Yuka Yanagisawa, Reiko Honma, Ken Shimizu, Mitsuhiro Hayashi, Sakura Azuma, Hitoshi Satoh, Emi Ito, Tetsunari Oyama, and Noritaka Yamaguchi
- Abstract
Supplementary Figure Legends 1-6 from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
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- 2023
3. Supplementary Figure 4 from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
- Author
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Shinya Watanabe, Kentaro Semba, Jun-ichiro Inoue, Kuniaki Tatsuta, Susumu Ohwada, Jun-ichi Imai, Mika Kawamura, Akira Nishikawa, Yuka Yanagisawa, Reiko Honma, Ken Shimizu, Mitsuhiro Hayashi, Sakura Azuma, Hitoshi Satoh, Emi Ito, Tetsunari Oyama, and Noritaka Yamaguchi
- Abstract
Supplementary Figure 4 from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
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- 2023
4. Data from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
- Author
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Shinya Watanabe, Kentaro Semba, Jun-ichiro Inoue, Kuniaki Tatsuta, Susumu Ohwada, Jun-ichi Imai, Mika Kawamura, Akira Nishikawa, Yuka Yanagisawa, Reiko Honma, Ken Shimizu, Mitsuhiro Hayashi, Sakura Azuma, Hitoshi Satoh, Emi Ito, Tetsunari Oyama, and Noritaka Yamaguchi
- Abstract
ErbB2-negative breast tumors represent a significant therapeutic hurdle because of a lack of effective molecular targets. Although NOTCH proteins are known to be involved in mammary tumorigenesis, the functional significance of these proteins in ErbB2-negative breast tumors is not clear. In the present study, we examined the expression of activated NOTCH receptors in human breast cancer cell lines, including ErbB2-negative and ErbB2-positive cell lines. Activated NOTCH1 and NOTCH3 proteins generated by γ-secretase were detected in most of the cell lines tested, and both proteins activated CSL-mediated transcription. Down-regulation of NOTCH1 by RNA interference had little or no suppressive effect on the proliferation of either ErbB2-positive or ErbB2-negative cell lines. In contrast, down-regulation of NOTCH3 significantly suppressed proliferation and promoted apoptosis of the ErbB2-negative tumor cell lines. Down-regulation of NOTCH3 did not have a significant effect on the ErbB2-positive tumor cell lines. Down-regulation of CSL also suppressed the proliferation of ErbB2-negative breast tumor cell lines, indicating that the NOTCH-CSL signaling axis is involved in cell proliferation. Finally, NOTCH3 gene amplification was detected in a breast tumor cell line and one breast cancer tissue specimen even though the frequency of NOTCH3 gene amplification was low (
- Published
- 2023
5. Supplementary Figure 2 from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
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Shinya Watanabe, Kentaro Semba, Jun-ichiro Inoue, Kuniaki Tatsuta, Susumu Ohwada, Jun-ichi Imai, Mika Kawamura, Akira Nishikawa, Yuka Yanagisawa, Reiko Honma, Ken Shimizu, Mitsuhiro Hayashi, Sakura Azuma, Hitoshi Satoh, Emi Ito, Tetsunari Oyama, and Noritaka Yamaguchi
- Abstract
Supplementary Figure 2 from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
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- 2023
6. Supplementary Figure 1 from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
- Author
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Shinya Watanabe, Kentaro Semba, Jun-ichiro Inoue, Kuniaki Tatsuta, Susumu Ohwada, Jun-ichi Imai, Mika Kawamura, Akira Nishikawa, Yuka Yanagisawa, Reiko Honma, Ken Shimizu, Mitsuhiro Hayashi, Sakura Azuma, Hitoshi Satoh, Emi Ito, Tetsunari Oyama, and Noritaka Yamaguchi
- Abstract
Supplementary Figure 1 from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
- Published
- 2023
7. Supplementary Figure 5 from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
- Author
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Shinya Watanabe, Kentaro Semba, Jun-ichiro Inoue, Kuniaki Tatsuta, Susumu Ohwada, Jun-ichi Imai, Mika Kawamura, Akira Nishikawa, Yuka Yanagisawa, Reiko Honma, Ken Shimizu, Mitsuhiro Hayashi, Sakura Azuma, Hitoshi Satoh, Emi Ito, Tetsunari Oyama, and Noritaka Yamaguchi
- Abstract
Supplementary Figure 5 from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
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- 2023
8. Supplementary Table 1 from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
- Author
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Shinya Watanabe, Kentaro Semba, Jun-ichiro Inoue, Kuniaki Tatsuta, Susumu Ohwada, Jun-ichi Imai, Mika Kawamura, Akira Nishikawa, Yuka Yanagisawa, Reiko Honma, Ken Shimizu, Mitsuhiro Hayashi, Sakura Azuma, Hitoshi Satoh, Emi Ito, Tetsunari Oyama, and Noritaka Yamaguchi
- Abstract
Supplementary Table 1 from NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
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- 2023
9. Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation
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Fumika Kan, Atsushi Takeda, Haruna Tamano, Naoto Oku, and Mika Kawamura
- Subjects
Blood Glucose ,Male ,medicine.medical_specialty ,Antimetabolites ,Hippocampus ,Deoxyglucose ,Biology ,Hippocampal formation ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Adenosine Triphosphate ,Neurochemical ,Corticosterone ,Internal medicine ,medicine ,Animals ,Amino Acids ,Rats, Wistar ,Swimming ,Behavior, Animal ,Depression ,Glutamate receptor ,Cell Biology ,medicine.disease ,Diet ,Rats ,Glutamine ,Zinc ,Endocrinology ,chemistry ,Zinc deficiency ,Calcium ,Glucocorticoid ,medicine.drug - Abstract
Abnormal behavior in zinc deficiency and its cause are poorly understood. In the present paper, behavior in the forced swim test and neurochemical changes in the brain associated with its behavior were studied focused on abnormal corticosterone secretion in zinc deficiency. The effect of chronic corticosterone treatment was also studied. Immobility time in the forced swim test was increased in young rats fed a zinc-deficient diet for 2 weeks, as well as corticosterone (40 mg/kg/day × 14 days)-treated control rats. The basal Ca2+ levels in the hippocampus, which were determined by fluo-4FF, AM, were increased in both brain slices from zinc-deficient and corticosterone-treated rats. Serum glucose level was decreased in zinc deficiency and hippocampal glucose metabolism, which is determined by [14C]2-deoxyglucose uptake, was elevated. Hippocampal ATP level was not decreased, whereas, the concentrations of glutamate, GABA and glutamine in the hippocampus, unlike the whole brain, were decreased in zinc deficiency. However, the decrease in these amino acids was restored by adrenalectomy prior to zinc deficiency. These results suggest that glucose is insufficient for the synthesis of amino acids in the hippocampus of zinc-deficient rats. It is likely that the neurochemical and metabolic changes in the hippocampus, which may be associated with abnormal corticosterone secretion, is the base of abnormal behavior associated with neuropsychological symptoms in zinc deficiency.
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- 2009
10. Application of quantitative gene expression analysis for pertussis vaccine safety control
- Author
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Kazunari Yamaguchi, Seishiro Naito, Mika Kawamura, Takuo Mizukami, Tetsuya Mizutani, Isao Hamaguchi, Haruka Momose, Hiroshi Kato, Yoshinobu Horiuchi, Jun-ichi Maeyama, Shinya Watanabe, Atsuko Masumi, Nobuo Nomura, Madoka Kuramitsu, Jun-ichi Imai, and Kazuya Takizawa
- Subjects
Male ,Microarray ,Positive correlation ,Gene expression ,medicine ,Animals ,Rats, Wistar ,Lung ,Gene ,Whooping cough ,Oligonucleotide Array Sequence Analysis ,Pertussis Vaccine ,General Veterinary ,General Immunology and Microbiology ,business.industry ,Gene Expression Profiling ,Body Weight ,Public Health, Environmental and Occupational Health ,Safety control ,medicine.disease ,Virology ,Rats ,Up-Regulation ,Infectious Diseases ,Immunology ,Toxicity ,Molecular Medicine ,Pertussis vaccine ,business ,medicine.drug - Abstract
Although vaccines are routinely used to prevent infectious diseases, little is known about the comprehensive influences caused by vaccines. In this study, we showed, using comprehensive gene expression analysis, that pertussis vaccine affected many genes in multiple organs of vaccine-treated animals. In particular, lung was revealed to be the most suitable target to evaluate pertussis vaccine toxicity. The 13 genes identified from the analysis of vaccine-treated lung at day 1 showed a clear dendrogram corresponding to pertussis vaccine toxicity. Furthermore, quantitative analysis of these genes revealed a positive correlation between their respective expression levels and the degree of toxic effects observed in samples that had been treated with various doses of reference pertussis vaccines. The quantification of this 13 gene-set is an indicator of the vaccine toxicity-related reaction.
- Published
- 2008
11. Two vaccine toxicity-related genes Agp and Hpx could prove useful for pertussis vaccine safety control
- Author
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Kazuya Takizawa, Kazunari Yamaguchi, Mika Kawamura, Yoshinobu Horiuchi, Jun-ichi Imai, Hiroshi Kato, Takuo Mizukami, Akihiko Yamamoto, Madoka Kuramitsu, Shinya Watanabe, Atsuko Masumi, Haruka Momose, Nobuo Nomura, Masaki Ochiai, Masayo Mochizuki, Seishiro Naito, Isao Hamaguchi, and Jun-ichi Maeyama
- Subjects
Male ,Microarray ,Leukocytosis ,Biology ,Polymerase Chain Reaction ,Hemopexin ,Gene expression ,medicine ,Animals ,RNA, Messenger ,Rats, Wistar ,Gene ,Oligonucleotide Array Sequence Analysis ,Pertussis Vaccine ,General Veterinary ,General Immunology and Microbiology ,Public Health, Environmental and Occupational Health ,Orosomucoid ,Virology ,Rats ,Reverse transcription polymerase chain reaction ,Infectious Diseases ,Real-time polymerase chain reaction ,Liver ,Pertussis Toxin ,Immunology ,Molecular Medicine ,Pertussis vaccine ,Safety ,DNA microarray ,medicine.drug - Abstract
Conventional animal tests such as leukocytosis promoting tests have been used for decades to evaluate toxicity of pertussis vaccine. Here, we examined gene expression in relation to the vaccine toxicity using a DNA microarray. Comparison of conventional animal test data with the DNA microarray-based gene expression data revealed a gene expression pattern highly correlated with leukocytosis in animals. Of 10,490 rat genes analyzed, two genes, alpha1-acid-glycoprotein (Agp) and hemopexin (Hpx), were found up-regulated by the toxin administration in a dose-dependent manner (assayed by a quantitative PCR based on the microarray). Variation of the gene expression was very small amongst the test animals, and the results were highly reproducible. These findings suggest that gene expression analysis of vaccine-treated animals can be used as an accurate and simple method of pertussis vaccine safety assessment.
- Published
- 2007
12. Influence of inhalation anesthesia assessed by comprehensive gene expression profiling
- Author
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Mika Kawamura, Atsuhiro Sakamoto, Jun-ichi Imai, Reiko Honma, Shinya Watanabe, Emi Ito, Yuka Yanagisawa, Akira Nishikawa, and Ryo Ogawa
- Subjects
Male ,Methyl Ethers ,Time Factors ,Biology ,Kidney ,Bioinformatics ,Sevoflurane ,Genetics ,medicine ,Animals ,Cluster Analysis ,Circadian rhythm ,Rats, Wistar ,Amphetamine ,Lung ,Oligonucleotide Array Sequence Analysis ,Inhalation ,Gene Expression Profiling ,Myocardium ,Brain ,Kidney metabolism ,General Medicine ,Rats ,PER2 ,CLOCK ,Gene expression profiling ,Gene Expression Regulation ,Liver ,Anesthetics, Inhalation ,RNA ,Spleen ,medicine.drug - Abstract
Although general anesthesia is routinely used as an essential surgical procedure and its harmlessness has been evaluated and endorsed by clinical outcomes, little is known about its comprehensive influence that is not reflected in mortality and morbidity. In this paper, we have shown that inhalation anesthesia affected the expression of1.5% of10,000 genes, by analyzing the expression profiles for multiple organs of rats anesthetized with sevoflurane. The small number of transcripts affected by the inhalation anesthesia comprised those specific to single and common in multiple organs. The former included genes mainly associated with drug metabolism in the liver and influenced by agents such as amphetamine in the brain. The latter contained multiple circadian genes. In the brain, we failed to detect the alteration of the clock gene expression with the exception of Per2, assuming that anesthesia perturbs circadian rhythms. Our findings provide the first assessment for the influence of inhalation anesthesia by approaches of experimental biology and genome science.
- Published
- 2005
13. Induction of indistinguishable gene expression patterns in rats by Vero cell-derived and mouse brain-derived Japanese encephalitis vaccines
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Haruka Momose, Jun-ichi Imai, Isao Hamaguchi, Mika Kawamura, Takuo Mizukami, Seishiro Naito, Atsuko Masumi, Jun-ichi Maeyama, Kazuya Takizawa, Madoka Kuramitsu, Nobuo Nomura, Shinya Watanabe, and Kazunari Yamaguchi
- Subjects
Microbiology (medical) ,Male ,Japanese Encephalitis Vaccines ,Gene Expression Profiling ,Body Weight ,Brain ,General Medicine ,Rats ,Mice ,Infectious Diseases ,Liver ,Encephalitis Viruses, Japanese ,Chlorocebus aethiops ,Animals ,Rats, Wistar ,Encephalitis, Japanese ,Vero Cells ,Blood Chemical Analysis ,Oligonucleotide Array Sequence Analysis - Abstract
Transcriptomics is an objective index that reflects the overall condition of cells or tissues, and transcriptome technology, such as DNA microarray analysis, is now being introduced for the quality control of medical products. In this study, we applied DNA microarray analysis to evaluate the character of Japanese encephalitis (JE) vaccines. When administered into rat peritoneum, Vero cell-derived and mouse brain-derived JE vaccines induced similar gene expression patterns in liver and brain. Body weights and blood biochemical findings were also similar after administration of the two vaccines. Our results suggest that the two JE vaccines are likely to have equivalent characteristics with regard to reactivity in rats.
- Published
- 2010
14. Constitutive activation of nuclear factor-kappaB is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines
- Author
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Akira Nishikawa, Jun-ichi Imai, Sakura Azuma, Yuka Yanagisawa, Reiko Honma, Noritaka Yamaguchi, Kentaro Semba, Mika Kawamura, Shinya Watanabe, Taku Ito, Jun-ichiro Inoue, and Emi Ito
- Subjects
Cancer Research ,medicine.medical_specialty ,Receptor, ErbB-2 ,Blotting, Western ,Breast Neoplasms ,Electrophoretic Mobility Shift Assay ,Biology ,Protein Serine-Threonine Kinases ,Transfection ,Metastasis ,Breast cancer ,Downregulation and upregulation ,Internal medicine ,medicine ,Tumor Cells, Cultured ,Humans ,RNA, Messenger ,Receptor ,Cell Proliferation ,Kinase ,Cell growth ,Reverse Transcriptase Polymerase Chain Reaction ,NF-kappa B ,Cancer ,General Medicine ,medicine.disease ,Endocrinology ,Oncology ,Receptors, Estrogen ,Carcinoma, Basal Cell ,Cancer research ,Female ,Breast disease ,Receptors, Progesterone - Abstract
Constitutive nuclear factor (NF)-kappaB activation is thought to be involved in survival, invasion, and metastasis in various types of cancers. However, neither the subtypes of breast cancer cells with constitutive NF-kappaB activation nor the molecular mechanisms leading to its constitutive activation have been clearly defined. Here, we quantitatively analyzed basal NF-kappaB activity in 35 human breast cancer cell lines and found that most of the cell lines with high constitutive NF-kappaB activation were categorized in the estrogen receptor negative, progesterone receptor negative, ERBB2 negative basal-like subtype, which is the most malignant form of breast cancer. Inhibition of constitutive NF-kappaB activation by expression of IkappaBalpha super-repressor reduced proliferation of the basal-like subtype cell lines. Expression levels of mRNA encoding NF-kappaB-inducing kinase (NIK) were elevated in several breast cancer cell lines, and RNA interference-mediated knockdown of NIK reduced NF-kappaB activation in a subset of the basal-like subtype cell lines with upregulated NIK expression. Taken together, these results suggest that constitutive NF-kappaB activation, partially dependent on NIK, is preferentially involved in proliferation of basal-like subtype breast cancer cells and may be a useful therapeutic target for this subtype of cancer.
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- 2009
15. NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells
- Author
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Ken Shimizu, Mika Kawamura, Mitsuhiro Hayashi, Jun-ichi Imai, Kuniaki Tatsuta, Yuka Yanagisawa, Akira Nishikawa, Jun-ichiro Inoue, Noritaka Yamaguchi, Shinya Watanabe, Reiko Honma, Emi Ito, Hitoshi Satoh, Sakura Azuma, Kentaro Semba, Tetsunari Oyama, and Susumu Ohwada
- Subjects
Cancer Research ,Receptor, ErbB-2 ,Apoptosis ,Breast Neoplasms ,Cell Growth Processes ,Biology ,Transfection ,Breast cancer ,Cell Line, Tumor ,medicine ,Humans ,skin and connective tissue diseases ,Autocrine signalling ,Receptor, Notch3 ,Receptors, Notch ,Cell growth ,Gene Amplification ,Cancer ,medicine.disease ,Oncology ,Notch proteins ,Immunology ,Cancer cell ,Cancer research ,RNA Interference ,Breast disease ,Signal transduction ,Signal Transduction - Abstract
ErbB2-negative breast tumors represent a significant therapeutic hurdle because of a lack of effective molecular targets. Although NOTCH proteins are known to be involved in mammary tumorigenesis, the functional significance of these proteins in ErbB2-negative breast tumors is not clear. In the present study, we examined the expression of activated NOTCH receptors in human breast cancer cell lines, including ErbB2-negative and ErbB2-positive cell lines. Activated NOTCH1 and NOTCH3 proteins generated by γ-secretase were detected in most of the cell lines tested, and both proteins activated CSL-mediated transcription. Down-regulation of NOTCH1 by RNA interference had little or no suppressive effect on the proliferation of either ErbB2-positive or ErbB2-negative cell lines. In contrast, down-regulation of NOTCH3 significantly suppressed proliferation and promoted apoptosis of the ErbB2-negative tumor cell lines. Down-regulation of NOTCH3 did not have a significant effect on the ErbB2-positive tumor cell lines. Down-regulation of CSL also suppressed the proliferation of ErbB2-negative breast tumor cell lines, indicating that the NOTCH-CSL signaling axis is involved in cell proliferation. Finally, NOTCH3 gene amplification was detected in a breast tumor cell line and one breast cancer tissue specimen even though the frequency of NOTCH3 gene amplification was low (
- Published
- 2008
16. FoxA1 as a lineage-specific oncogene in luminal type breast cancer
- Author
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Jun-ichi Imai, Yuka Yanagisawa, Noritaka Yamaguchi, Akira Nishikawa, Reiko Honma, Kentaro Semba, Jun-ichiro Inoue, Sakura Azuma, Mika Kawamura, Kuniaki Tatsuta, Emi Ito, and Shinya Watanabe
- Subjects
Hepatocyte Nuclear Factor 3-alpha ,Mammary gland ,Biophysics ,CA 15-3 ,Breast Neoplasms ,Biology ,Biochemistry ,Breast cancer ,Cell Line, Tumor ,medicine ,Biomarkers, Tumor ,Humans ,skin and connective tissue diseases ,Molecular Biology ,Transcription factor ,Oncogene ,Cell Biology ,Oncogenes ,medicine.disease ,Neoplasm Proteins ,medicine.anatomical_structure ,Cell Transformation, Neoplastic ,Cell culture ,Cancer cell ,Immunology ,Cancer research ,FOXA1 - Abstract
The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast cancer. We found that FoxA1 is expressed at high levels in all ErbB2-positive cell lines and a subset of ErbB2-negative cell lines. Down-regulation of FoxA1 by RNA interference significantly suppressed proliferation of ErbB2-negative and FoxA1-positive breast cancer cell lines. Down-regulation of FoxA1 also enhanced the toxic effect of Herceptin on ErbB2-positive cell lines through induction of apoptosis. Taken together with previous data that FoxA1 is a marker of luminal cells in mammary gland, our present results suggest that FoxA1 plays an important role as a lineage-specific oncogene in proliferation of cancer cells derived from mammary luminal cells.
- Published
- 2007
17. Hippocampal calcium dyshomeostasis and long-term potentiation in 2-week zinc deficiency
- Author
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Mika Kawamura, Kohei Yamada, Haruna Tamano, Sayuri Fuke, Naoto Oku, and Atsushi Takeda
- Subjects
medicine.medical_specialty ,Long-Term Potentiation ,chemistry.chemical_element ,Morris water navigation task ,Hippocampal formation ,Calcium ,Hippocampus ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Mice ,Corticosterone ,Internal medicine ,medicine ,Animals ,Homeostasis ,Chemistry ,Long-term potentiation ,Cell Biology ,medicine.disease ,Electric Stimulation ,Zinc ,Endocrinology ,medicine.anatomical_structure ,Schaffer collateral ,Zinc deficiency ,Tetanic stimulation - Abstract
On the basis of abnormal neuropsychological behavior in the open-field test after 2-week zinc deprivation, neurochemical response was examined in young mice fed a zinc-deficient diet for 2 weeks. Serum corticosterone concentration was markedly higher in zinc-deficient mice than in the control mice. Basal signals of intracellular calcium (fluo-4 FF) were also significantly more in hippocampal slices from zinc-deficient mice. These results suggest that basal Ca2+ levels in hippocampal cells are increased by zinc deficiency. On the other hand, Schaffer collateral long-term potentiation (LTP) was unaffected by zinc deficiency; the averaged fEPSP after tetanic stimulation was 162 ± 8% of baseline value in the control and 172 ± 22% in zinc-deficient mice. In the Morris water maze, there was also no significant difference in learning behavior for the hidden platform task between the control and zinc-deficient mice. The present study indicates that Schaffer collateral LTP associated with spatial cognition performance are unaffected by calcium dyshomeostasis in the hippocampus elicited by 2-week zinc deprivation, which may be linked to the increased serum corticosterone concentration.
- Published
- 2007
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