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Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation
- Source :
- Neurochemistry International. 55:536-541
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Abnormal behavior in zinc deficiency and its cause are poorly understood. In the present paper, behavior in the forced swim test and neurochemical changes in the brain associated with its behavior were studied focused on abnormal corticosterone secretion in zinc deficiency. The effect of chronic corticosterone treatment was also studied. Immobility time in the forced swim test was increased in young rats fed a zinc-deficient diet for 2 weeks, as well as corticosterone (40 mg/kg/day × 14 days)-treated control rats. The basal Ca2+ levels in the hippocampus, which were determined by fluo-4FF, AM, were increased in both brain slices from zinc-deficient and corticosterone-treated rats. Serum glucose level was decreased in zinc deficiency and hippocampal glucose metabolism, which is determined by [14C]2-deoxyglucose uptake, was elevated. Hippocampal ATP level was not decreased, whereas, the concentrations of glutamate, GABA and glutamine in the hippocampus, unlike the whole brain, were decreased in zinc deficiency. However, the decrease in these amino acids was restored by adrenalectomy prior to zinc deficiency. These results suggest that glucose is insufficient for the synthesis of amino acids in the hippocampus of zinc-deficient rats. It is likely that the neurochemical and metabolic changes in the hippocampus, which may be associated with abnormal corticosterone secretion, is the base of abnormal behavior associated with neuropsychological symptoms in zinc deficiency.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Antimetabolites
Hippocampus
Deoxyglucose
Biology
Hippocampal formation
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Adenosine Triphosphate
Neurochemical
Corticosterone
Internal medicine
medicine
Animals
Amino Acids
Rats, Wistar
Swimming
Behavior, Animal
Depression
Glutamate receptor
Cell Biology
medicine.disease
Diet
Rats
Glutamine
Zinc
Endocrinology
chemistry
Zinc deficiency
Calcium
Glucocorticoid
medicine.drug
Subjects
Details
- ISSN :
- 01970186
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Neurochemistry International
- Accession number :
- edsair.doi.dedup.....03c2816e3bdeb7f646a09852f935b73e