1. Designed Mannosylerythritol Lipid Analogues Exhibiting Both Selective Cytotoxicity Against Human Skin Cancer Cells and Recovery Effects on Damaged Skin Cells.
- Author
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Meng J, Yasui C, Shida M, Toshima K, and Takahashi D
- Subjects
- Humans, Cell Line, Tumor, Skin Neoplasms drug therapy, Skin Neoplasms pathology, Drug Design, Skin drug effects, Skin pathology, Drug Screening Assays, Antitumor, Cell Survival drug effects, Membrane Fluidity drug effects, Glycolipids chemistry, Glycolipids pharmacology, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry
- Abstract
Mannosylerythritol lipids (MELs) are a class of amphipathic molecules bearing a hydrophilic 4-O-β-D-mannopyranosyl-D-erythritol skeleton. Here, we designed and synthesized four kinds of MEL analogues R-MEL-A ([2R,3S]-erythritol type), S-mannosylthreitol lipid (MTL)-A ([2S,3S]-threitol type), R-MTL-A ([2R,3R]-threitol type), and α-S-MEL-A ([2S,3R]-erythritol type) using our previously reported boron-mediated aglycon delivery (BMAD) method and a neighboring group assisted glycosylation method. The selective cytotoxicity of the target compounds against cancer cells was evaluated, with R-MTL-A showing the highest selective cytotoxicity against human skin squamous carcinoma HSC-5 cells. Our findings suggest that R-MTL-A induces necrosis-like cell death against HSC-5 cells by decreasing cell membrane fluidity. R-MTL-A also exhibits an efficient recovery effect on damaged skin cells, indicating that R-MTL-A has potential as a lead compound for new cosmeceuticals with both cancer cell-selective toxicity and recovery effects on damaged skin cells., (© 2024 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)
- Published
- 2024
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