1. Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes
- Author
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Daniel J. Green, Neale Cohen, Michael Wheeler, Robyn N. Larsen, Paddy C. Dempsey, David W. Dunstan, Parneet Sethi, Ashleigh R. Homer, Megan S. Grace, Frances C. Taylor, Neville Owen, and Bronwyn A. Kingwell
- Subjects
Adult ,Blood Glucose ,Male ,Time Factors ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,Glycemic Control ,Type 2 diabetes ,Nocturnal ,Sitting ,Diabetes mellitus ,sedentary behaviour ,medicine ,Humans ,Hypoglycemic Agents ,Circadian rhythm ,Exercise ,Aged ,Glycemic ,Sitting Position ,Nutrition and Dietetics ,nocturnal glucose ,business.industry ,postprandial glucose ,Middle Aged ,Postprandial Period ,medicine.disease ,Circadian Rhythm ,Diabetes Mellitus, Type 2 ,active breaks ,Anesthesia ,Activity time ,Female ,type 2 diabetes ,Sedentary Behavior ,Glucose monitors ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
Background & aims Whether the frequency of interruptions to sitting time involving simple resistance activities (SRAs), compared to uninterrupted sitting, differentially affected 22 h glycemic control in adults with medication-controlled type 2 diabetes (T2D). Methods & results Twenty-four participants (13 men; mean ± SD age 62 ± 8 years) completed three 8 h laboratory conditions: SIT: uninterrupted sitting; SRA3: sitting interrupted with 3 min of SRAs every 30 min; and, SRA6: sitting interrupted with 6 min of SRAs every 60 min. Flash glucose monitors assessed glycemic control over a 22 h period. No differences were observed between conditions for overall 22 h glycemic control as measured by AUCtotal, mean glucose and time in hyperglycemia. During the 3.5 h post-lunch period, mean glucose was significantly lower during SRA6 (10.1 mmol·L−1, 95%CI 9.2, 11.0) compared to SIT (11.1 mmol·L−1, 95%CI 10.2, 12.0; P = 0.006). Post-lunch iAUCnet was significantly lower during SRA6 (6.2 mmol·h·L−1, 95%CI 3.3, 9.1) compared to SIT (9.9 mmol·h·L−1, 95%CI 7.0, 12.9; P = 0.003). During the post-lunch period, compared to SIT (2.2 h, 95%CI 1.7, 2.6), time in hyperglycemia was significantly lower during SRA6 (1.5 h, 95%CI 1.0, 1.9, P = 0.001). Nocturnal mean glucose was significantly lower following the SRA3 condition (7.6 mmol·L−1, 95%CI 7.1, 8.1) compared to SIT (8.1 mmol·L−1, 95%CI 7.6, 8.7, P = 0.024). Conclusions With standardized total activity time, less-frequent active interruptions to sitting may acutely improve glycemic control; while more-frequent interruptions may be beneficial for nocturnal glucose in those with medication-controlled T2D.
- Published
- 2021