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Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
- Source :
- Alzheimer's & Dementia : Translational Research & Clinical Interventions
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline.<br />Highlights • Older adults spend a majority of time in sedentary behavior. • Sedentary behavior may be linked to cognitive decline via glycemic control. • Replacing sitting with intermittent light activity can improve glycemic control. • Future research should determine if light activity can forestall cognitive decline. • Engaging in more light activity may be an achievable public health target.
- Subjects :
- Gerontology
Psychological intervention
BF
RC1200
03 medical and health sciences
0302 clinical medicine
medicine
Global health
Dementia
030212 general & internal medicine
Cognitive decline
Risk factor
Exercise
Glycemic
Glucose metabolism
Light-intensity activity
Physical activity
Diabetes
Cognition
Alzheimer's disease
medicine.disease
Breaks in sedentary time
Psychiatry and Mental health
Light intensity
Sedentary behavior
Perspective
RC0321
Neurology (clinical)
Cognitive function
Psychology
GV
030217 neurology & neurosurgery
Sitting
Subjects
Details
- Language :
- English
- ISSN :
- 23528737
- Volume :
- 3
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia : Translational Research & Clinical Interventions
- Accession number :
- edsair.doi.dedup.....6076a86ac68b8a894970962bf7dfc27e