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Acute effects of interrupting prolonged sitting on vascular function in type 2 diabetes
- Publication Year :
- 2021
- Publisher :
- American Physiological Society, 2021.
-
Abstract
- In healthy and overweight/obese adults, interrupting prolonged sitting with activity bouts mitigates impairment in vascular function. However, it is unknown whether these benefits extend to those with type 2 diabetes (T2D), nor whether an optimal frequency of activity interruptions exist. We examined the acute effects on vascular function in T2D of interrupting prolonged sitting with simple resistance activities (SRA) at different frequencies. In a randomized crossover trial, 24 adults with T2D (35-70 yr) completed three 7-h conditions: 1) uninterrupted sitting (SIT), 2) sitting with 3-min bouts of SRA every 30 min (SRA3), and 3) sitting with 6 min bouts of SRA every 60 min (SRA6). Femoral artery flow-mediated dilation (FMD), resting shear rate, blood flow, and endothelin-1 were measured at 0, 1, 3.5, 4.5, and 6.5-7 h. Mean femoral artery FMD over 7 h was significantly higher in SRA3 (4.1 ± 0.3%) compared with SIT (3.7 ± 0.3%, P = 0.04) but not in SRA6. Mean resting femoral shear rate over 7 h was increased significantly for SRA3 (45.3 ± 4.1/s, P < 0.001) and SRA6 (46.2 ± 4.1/s, P < 0.001) relative to SIT (33.1 ± 4.1/s). Endothelin-1 concentrations were not statistically different between conditions. Interrupting sitting with activity breaks every 30 min, but not 60 min, significantly increased mean femoral artery FMD over 7 h, relative to SIT. Our findings suggest that more frequent and shorter breaks may be more beneficial than longer, less frequent breaks for vascular health in those with T2D.NEW & NOTEWORTHY This is the first trial to examine both the effects of interrupting prolonged sitting on vascular function in type 2 diabetes and the effects of the frequency and duration of interruptions. Brief, simple resistance activity bouts every 30 min, but not every 60 min, increased mean femoral artery flow-mediated dilation over 7 h, relative to uninterrupted sitting. With further supporting evidence, these initial findings can have important implications for cardiovascular health in type 2 diabetes.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Physiology
Femoral artery
Type 2 diabetes
030204 cardiovascular system & hematology
Overweight
Sitting
arteries
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
medicine.artery
Diabetes mellitus
Internal medicine
sedentary behavior
medicine
Humans
blood flow
Endothelial dysfunction
Brachial artery
Aged
Sitting Position
Cross-Over Studies
Endothelin-1
business.industry
Resistance Training
030229 sport sciences
Middle Aged
medicine.disease
Crossover study
Femoral Artery
Vasodilation
Treatment Outcome
Diabetes Mellitus, Type 2
Regional Blood Flow
Cardiology
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a667a53299201d4415622e3bf34b90fd