107 results on '"M, Ingrosso"'
Search Results
2. Low-power versus high-power en-bloc no-touch HoLEP: Comparing feasibility, safety and efficacy
- Author
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C.M. Cracco, M. Ingrosso, N. Russo, and C.M. Scoffone
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Urology - Published
- 2017
3. A controlled study of 20 mg famotidine nocte vs. 150 mg ranitidine nocte for the prevention of duodenal ulcer relapse
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A. Blasi, L. Capurso, E. Bovero, M. Koch, M. Ingrosso, Giorgio Cavallini, M. Agnello, A. Calacro, R. De Franchis, Roberto Corinaldesi, Gabriele Mazzacca, Paolo Paoluzi, Giorgio Zoli, M. Lazzaroni, Giovanni Gasbarrini, L. A. Scuro, R. Cheli, Antonio Francavilla, Luigi Barbara, Calogero Surrenti, M. Guslandi, Remo Naccarato, F. Sabbatini, F. Di Mario, A. Mangiameli, and G. Bianchi Porro
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Adult ,Male ,medicine.medical_specialty ,Hepatology ,Gastroenterology ,Pharmacology (medical) ,medicine.medical_treatment ,Ranitidine ,NO ,law.invention ,Double-Blind Method ,Randomized controlled trial ,Histamine H2 receptor ,Recurrence ,law ,Internal medicine ,medicine ,Humans ,Aged ,Chemotherapy ,Intention-to-treat analysis ,business.industry ,Middle Aged ,Famotidine ,medicine.anatomical_structure ,Tolerability ,Duodenal Ulcer ,Duodenum ,Female ,business ,medicine.drug - Abstract
A 24-week, double-blind, randomized study at 13 centres compared the efficacy and safety of 20 mg famotidine nocte and 150 mg ranitidine h.s. for the prevention of duodenal ulcer recurrence. All participants had been successfully treated for an acute duodenal ulcer with 40 mg famotidine nocte. Patients were endoscoped at baseline and at 24 weeks, unless symptoms warranted earlier examination: of the 208 patients enrolled, 86 who received famotidine and 84 who received ranitidine met all protocol criteria and were considered evaluable. Intention to treat and per protocol analyses showed non-significant trends in favour of famotidine (P = 0.44 and 0.16, respectively). During the 24-week observation period, 16.3% of the famotidine group and 25% of the ranitidine group had an ulcer recurrence (95% CI of percentage difference -0.22 + 0.04). At 24 weeks, relief of day and night pain was reported by 81.2% and 91.8% of the famotidine-treated patients, respectively. The corresponding figures in the ranitidine group were 73.5% and 85.5%. No laboratory abnormalities related to the study-drugs were noted and only two drug related (possibly or probably) adverse experiences were reported, both in the famotidine group. The data from this study therefore, supports the conclusion that the efficacy of 20 mg famotidine nocte is comparable to that of ranitidine in preventing duodenal ulcer recurrence, with comparable tolerability for long-term therapy.
- Published
- 2007
4. Evidence of Small-Bowel Involvement in Hereditary Hemorrhagic Telangiectasia: a Capsule-Endoscopic Study
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M. Ingrosso, A Cirulli, Carlo Sabbà, Mariabeatrice Principi, Mauro Gallitelli, Antonio Pisani, and A. Francavilla
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Adult ,Male ,medicine.medical_specialty ,Gastrointestinal bleeding ,Video Recording ,Capsules ,Telangiectases ,Gastroenterology ,Endoscopy, Gastrointestinal ,law.invention ,Angioma ,Capsule endoscopy ,law ,Internal medicine ,Intestine, Small ,medicine ,Humans ,Prospective Studies ,Telangiectasia ,Aged ,medicine.diagnostic_test ,Esophagogastroduodenoscopy ,business.industry ,Vascular disease ,Age Factors ,Middle Aged ,medicine.disease ,Endoscopy ,Gastrointestinal Tract ,Female ,Telangiectasia, Hereditary Hemorrhagic ,Esophagoscopy ,medicine.symptom ,business - Abstract
BACKGROUND AND STUDY AIMS Hereditary hemorrhagic telangiectasia (HHT) is an autosomal-dominant vascular disorder leading to telangiectases and arteriovenous malformations of the skin, mucosa, and viscera. Telangiectases in the upper gastrointestinal tract are known, but data regarding possible small-bowel involvement are scarce due to the technical difficulty of exploring the entire gastrointestinal tract. The aim of the present study was to use capsule endoscopy (CE) to determine the prevalence of small-bowel telangiectases in HHT patients. PATIENTS AND METHODS From December 2001 to September 2002, 20 consecutive adult HHT patients at an interdepartmental HHT center were prospectively evaluated. All patients underwent esophagogastroduodenoscopy (EGD) followed by CE within 24 h. The telangiectases were scored according to commonly accepted criteria by two endoscopists and two observers of the video-capsule images, who were blinded to each other's findings. RESULTS EGD revealed gastric telangiectases in 15 of the 20 patients (75 %), while CE demonstrated small-bowel involvement in 10 of 18 patients (56 %; images were not recorded for two patients due to battery failure). No preferential site for telangiectasia was found between the jejunum and the terminal ileum. All patients who were positive on CE were also found to have gastric involvement at EGD. Patients with small-bowel telangiectases were significantly older than those without (62.5 years vs. 45 years; P < 0.02). CONCLUSIONS This study established a 56 % prevalence of small-bowel telangiectases in patients with HHT. This new endoscopic technique will probably change the etiological diagnosis of occult bleeding in HHT patients (which is too often attributed only to epistaxis) and may also be able to alter treatment strategies in HHT patients with gastrointestinal bleeding.
- Published
- 2004
5. Lupus Nephritis Improvement After Anti‐tumor Necrosis Factor Alpha Monoclonal Antibody (Infliximab) Treatment for Crohn's Disease: A Case Report
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Antonio Pisani, A. Di Leo, Carmine Panella, Annacinzia Amoruso, Antonio Francavilla, M. Ingrosso, Enzo Ierardi, S. Marangi, and Mariabeatrice Principi
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Adult ,medicine.drug_class ,Immunology ,Lupus nephritis ,Disease ,Toxicology ,Monoclonal antibody ,Crohn Disease ,medicine ,Humans ,Immunology and Allergy ,Pharmacology ,Crohn's disease ,biology ,Tumor Necrosis Factor-alpha ,business.industry ,Antibodies, Monoclonal ,General Medicine ,medicine.disease ,Lupus Nephritis ,Infliximab ,Pyuria ,biology.protein ,Female ,Tumor necrosis factor alpha ,Antibody ,medicine.symptom ,business ,medicine.drug - Abstract
Association between Crohn's disease (CD) and lupus nephritis is very rare and, to the best of our knowledge, it has been described only once. We report here a clinical case of CD occurred in a young woman 8 years after a diagnosis of lupus nephritis according to clinical, laboratory and histological criteria. CD was unresponsive to steroids and immunosuppressants and, therefore, the patient was treated with anti-tumour necrosis factor alpha monoclonal antibody (Infliximab). This therapy led to the remission of both CD (50% of Crohn's Disease Activity Index--CDAI--decrease) and lupus nephritis (disappearance of pyuria in absence of infection, significant increase of serum albumin and improvement of renal function tests). The immunological background of both diseases has to be taken into account to explain either the association of the two disorders or the therapeutic response. Moreover, this clinical case confirms and extends the concept that in patients with CD a more accurate detection of autoimmune associated disorders is required.
- Published
- 2004
6. Topical butyrate improves efficacy of 5-ASA in refractory distal ulcerative colitis: results of a multicentre trial
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S Giaccari, Gabriele Riegler, G. D’Albasio, V. Annese, D. Valpiani, Renata D'Incà, Piero Vernia, C. Mansi, Giampaolo Bresci, del Retto, Renzo Caprilli, M. Ingrosso, and Gisc
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medicine.medical_specialty ,Randomization ,business.industry ,Clinical Biochemistry ,General Medicine ,medicine.disease ,Biochemistry ,Ulcerative colitis ,Gastroenterology ,Inflammatory bowel disease ,law.invention ,Surgery ,Clinical trial ,chemistry.chemical_compound ,Mesalazine ,chemistry ,Randomized controlled trial ,Refractory ,law ,Internal medicine ,medicine ,Colitis ,business - Abstract
Background The treatment of distal ulcerative colitis, refractory to conventional 5-ASA/steroid treatment, is still a matter of debate. The present study aimed at confirming, with adequate statistical power, previous data indicating the usefulness of topical butyrate and 5-ASA in the treatment of this condition. Design Double-blind, placebo-controlled, multicentre study. A total of 51 patients with distal (
- Published
- 2003
7. Recent results from KLOE at DAΦNE
- Author
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G. Cataldi, C. Bloise, M. Napolitano, A. Denig, R. Messi, P. Gauzzi, G. De Robertis, G. Lanfranchi, L. Passalacqua, E. Valente, A. Ferrari, G. W. Yu, A. Antonelli, M. Incagli, M. Ingrosso, P. Santangelo, A. Farilla, E. Spiriti, Vincenzo Patera, R. D. Schamberger, G. Saracino, P. Ciambrone, Filippo Ceradini, F. Bossi, G. L. Tong, A. Sciubba, A. Franceschi, F. Cervelli, C. Kuo, D. Leone, R. Caloi, Enrico Pasqualucci, G. Capon, G. Venanzoni, G. Felici, G. De Zorzi, P. Branchini, M. L. Ferrer, Stefano Veneziano, A. Doria, A. Passeri, B. Valeriani, S. A. Bulychjov, F. Cevenini, S. W. Han, F. Murtas, A. Di Domenico, Luca Tortora, G. Chiefari, E. Graziani, C. Di Donato, T. Spadaro, A. Nedosekin, E. De Lucia, C. Bacci, Cesare Bini, O. Erriquez, F. Ambrosino, S. Bertolucci, P. Campana, Emilio Petrolo, P. Franzini, F. Grancagnolo, Barbara Sciascia, S. Miscetti, S. Di Falco, V. Bocci, S. Conetti, G. Bencivenni, M. Antonelli, S. Müller, Francesco Lacava, P. De Simone, L. Merola, M. Moulson, E. Gorini, Ludovico Pontecorvo, C. Gatti, W. Mei, M. Casarsa, M. Matsyuk, G. Xu, C. Forti, F. Ruggieri, V. Kulikov, M. Palutan, G. Carboni, F. Lu, J. Lee-Franzini, W. Kluge, M. Martemianov, L. Paoluzi, Paolo Valente, F. Nguyen, I. Sfiligoi, M. Primavera, V. Casavola, M. Dreucci, A. Ventura, S. Dell'Agnello, E. Santovetti, F. Scuri, S. Giovannella, A. Aloisio, and G. Finocchiaro
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Nuclear physics ,Pseudoscalar ,Physics ,Nuclear and High Energy Physics ,Particle physics ,Branching fraction ,Branching (polymer chemistry) ,Atomic and Molecular Physics, and Optics - Abstract
The KLOE experiment at the DAΦNE e+e− collider and its physics program is presented. The most recent results obtained using the data collected during the year 2000 (about 20 pb−1) are presented, in particular the ratio of branching ratios BR(KS → π+π−)/BR(Ks → π0π0), the branching ratio for the Ke3 decay of the KS, the ratio BR(φ → η′γ)/BR(φ → ηγ) and the pseudoscalar mixing angle ϕP, and the branching ratios for the decays φ → f0γ and φ → a0γ.
- Published
- 2002
8. La nozione di colpa grave quale elemento soggettivo della responsabilità per danno erariale a quasi 20 anni dalla legge 20 dicembre 1996 n. 639
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S. Alfonso, C. Amatucci, S. Auriemma, E. Bonelli, V. Bratti, R. Capunzo, M. Crisci, D. Crocco, L. de Maio, I. De Musso, M. Ingrosso, D. Luongo, C. Manzo, L. Monfeli, A. Natale, M. Oricchio, V. Raeli, M. Sciascia, G. Veccia, AA.VV., D. Crocco, Alfonso, S., Amatucci, C., Auriemma, S., Bonelli, E., Bratti, V., Capunzo, R., Crisci, M., Crocco, D., de Maio, L., De Musso, I., Ingrosso, M., Luongo, D., Manzo, C., Monfeli, L., Natale, A., Oricchio, M., Raeli, V., Sciascia, M., and Veccia, G.
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funzione amministrativa, colpevolezza, colpa grave, responsabilità amministrativa, corte dei conti, gradualità, eccesso di potere finanziario - Abstract
Il saggio parte dalla reinterpretazione dell'art. 97 Cost. per cogliere le linee evolutive della trasfigurazione della funzione amministrativa come amministrazione "di servizio", in connessione con la nuova conformazione dell'elemento psicologico della responsabilità amministrativa. Partendo da tale premessa si giunge alla conclusione che la più qualificata definizione legislativa dell'elemento psicologico della colpa produce un progressivo restringimento dell'area di applicabilità della responsabilità amministrativa, finendo per incidere sulla sfera stessa di cognizione della Corte dei conti e sull'ambito concreto della sua giurisdizione. Inoltre, sulla base della giurisprudenza della stessa Corte dei conti, si cerca di dimostrare che l'elemento psicologico della colpa grave si connota di una propria "tipicità" nell'illecito contabile, ancorché per il suo accertamento possa farsi riferimento alla tradizionale concezione "normativa" della colpa. Il lavoro si conclude col tentativo di enucleazione di figure sintomatiche tipiche ai fini della configurazione dell'eccesso di "potere finanziario".
- Published
- 2014
9. Entéroscopie—Vue d’ensemble
- Author
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M. Ingrosso
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,General surgery ,medicine ,Radiology, Nuclear Medicine and imaging ,Interventional radiology ,business ,Abdominal surgery ,Endoscopy - Published
- 2001
10. Santorinicele and recurrent acute pancreatitis in pancreas divisum: diagnosis with dynamic secretin-stimulated magnetic resonance pancreatography and endoscopic treatment
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Massimiliano Mutignani, Andrea Tringali, M. Ingrosso, Guido Costamagna, and Riccardo Manfredi
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medicine.medical_specialty ,Pancreatic disease ,Secretin ,Gastrointestinal Agents ,Recurrence ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Cyst ,Endoscopy, Digestive System ,Pancreas ,Aged ,Cholangiopancreatography, Endoscopic Retrograde ,Pancreas divisum ,medicine.diagnostic_test ,Cysts ,business.industry ,Gastroenterology ,Pancreatic Diseases ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Endoscopy ,Treatment Outcome ,Pancreatitis ,Acute Disease ,Drainage ,Female ,Radiology ,business ,Complication ,Dilatation, Pathologic ,Follow-Up Studies - Published
- 2000
11. Catholic Bridging Efforts with China
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S. Marangi, Enzo Ierardi, Alastair Forbes, M. Ingrosso, Mariabeatrice Principi, Vincenzo De Francesco, O. Burattini, Antonio Francavilla, Richard O. Day, Antonio Pisani, Carmine Panella, and Alfredo Di Leo
- Subjects
Crohn's disease ,Pathology ,medicine.medical_specialty ,Stromal cell ,Sociology and Political Science ,Religious studies ,Inflammation ,Biology ,medicine.disease ,Epithelium ,Syndecan 1 ,medicine.anatomical_structure ,Intestinal mucosa ,medicine ,Immunohistochemistry ,Tumor necrosis factor alpha ,medicine.symptom - Abstract
Tumor necrosis factor alpha (TNFalpha) in intestinal mucosa plays a key role in the inflammation characterizing Crohn's disease (CD). Moreover, adhesion molecule syndecan-1 mediates the maintenance of mucosal integrity and supports tissue repair. Therefore, our aim in this study was to correlate simultaneous expression of TNFalpha and syndecan-1 in patients affected by CD. Biopsies from 10 patients with CD of large bowel and 10 subjects with irritable bowel syndrome (controls) were studied by immunohistochemical detection of both TNFalpha and syndecan-1 on successive serial sections. Overall labeling index (OLI) was indicated by the percentage of positive stromal (i.e., nonepithelial) cells/1000 counted in randomized fields, whereas selected labeling index (SLI) was represented by the simultaneous evaluation of both molecules in a same single selected field of each specimen. TNFalpha and syndecan-1 OLI were significantly higher in CD compared with controls, while SLI showed an inverse relationship between the molecules in CD which was not observed in controls. Epithelial syndecan-1 cytoplasmatic staining of superficial epithelium was associated with loss of basolateral staining in the crypts and high stromal TNFalpha in CD. In conclusion, TNFalpha and syndecan-1 expression is increased in the intestinal mucosa of patients with CD. However, the expression of the two molecules is inversely related when a single field is considered, these data supporting the possibility of a downregulation exerted by TNFalpha.
- Published
- 2000
12. [Untitled]
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Gabriele Riegler, M. Ingrosso, A. Andreoli, Maria Itria Russo, M.T. Tartaglione, Maurizio Vecchi, M.T. Fiorentini, Claudio Papi, D. Valpiani, Renata D'Incà, and Romano Carratù
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medicine.medical_specialty ,Physiology ,business.industry ,Incidence (epidemiology) ,Gastroenterology ,medicine.disease ,Ulcerative colitis ,Surgery ,Quartile ,Weight loss ,Internal medicine ,Epidemiology ,Severity of illness ,medicine ,Colitis ,Risk factor ,medicine.symptom ,business - Abstract
Clinical–endoscopic parameters of UC presentation were studied in 1705 out-patients, observed consecutively in 17 Italian gastroenterology centers (males 60.2%; average age at diagnosis 38.5 ± 16.4 years), and were subdivided arbitrarily into quartile age groups at diagnosis (0–25, 26–35, 36–50, >50). A significantly greater prevalence in males, increasing with age, was shown at diagnosis (P = 0.0002), which seems to correlate with the condition of being an ex-smoker, most frequently found in males. The greater frequency of exsmokers could also, in part, justify the second peak of incidence in old age. Greater colitis extent, greater clinical activity, and greater use of steroids as the first therapeutic step are shown to prevail among younger patients and among women (P = 0.02 and P = 0.019, respectively). The same is observed for symptoms mainly representing clinical severity such as diarrhea, fever, and weight loss (P = 0.004; P = 0.006; P = 0.009, respectively). This study confirms the UC risk factor represented by the condition of being an ex-smoker and shows a greater severity of illness on diagnosis in younger patients.
- Published
- 2000
13. Hepatobiliary Alterations in Patients with Inflammatory Bowel Disease: A Multicenter Study
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S Morini, Giovanni Corrao, Renzo Caprilli, M. Ingrosso, C. Del Vecchio Blanco, R Carratù, Maria Antonietta Pelli, Claudio Papi, V. Di Leo, D. Valpiani, D. Cantarini, G.C. Sturniolo, Paolo Usai, Renata D'Incà, and Gabriele Riegler
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,medicine.disease ,Ulcerative colitis ,Inflammatory bowel disease ,Biliary disease ,chemistry.chemical_compound ,Liver disease ,Mesalazine ,chemistry ,Biliary tract ,Internal medicine ,medicine ,Colitis ,Liver function tests ,business - Abstract
Background and Methods: Four hundred and eighty-four patients with inflammatory bowel disease underwent clinical examination, ultrasonography, and biochemical liver function tests, to estimate the prevalence of hepatobiliary alterations. The patient group included patients without a history of liver disease. Controls were recruited from patients with functional symptoms. Results: More patients with ulcerative colitis than controls had liver steatosis and increased alkaline phosphatase levels. Factors increasing the probability of liver damage were long-standing disease, the presence of moderate/severe disease activity, and treatment with steroids and mesalazine. A significant association was found between biliary disease and long-standing colitis and also therapy with steroids and mesalazine. Alkaline phosphatase and aminotransferase levels were significantly higher in Crohn's disease patients than in controls. Hepatic and biliary damage was found more commonly in the 1st year after diagnosis. Conclusions...
- Published
- 1998
14. Proliferative activity of gastric epithelium in progressive stages ofHelicobacter pylori infection
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L Polimeno, Annacinzia Amoruso, A. Traversa, C. Panella, M. Ingrosso, T. Balzano, Enzo Ierardi, and A. Francavilla
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Adult ,Male ,medicine.medical_specialty ,Pathology ,Physiology ,Chronic gastritis ,Biology ,Gastroenterology ,Helicobacter Infections ,Stomach Neoplasms ,Proliferating Cell Nuclear Antigen ,Internal medicine ,Metaplasia ,Gastroscopy ,medicine ,Humans ,Aged ,Helicobacter pylori ,Stomach ,Intestinal metaplasia ,Middle Aged ,medicine.disease ,biology.organism_classification ,Immunohistochemistry ,Precancerous condition ,Foveolar cell ,medicine.anatomical_structure ,Gastric Mucosa ,Gastritis ,Chronic Disease ,Female ,medicine.symptom ,Cell Division - Abstract
Helicobacter pylori (HP) infection is the main etiopathogenetic agent responsible for inflammatory and ulcerative changes in gastroduodenal mucosa and the basis for both intestinal and diffuse types of gastric carcinoma. In this latter case, intestinal metaplasia is the intermediary between gastritis and cancer. In this study we describe the proliferative activity of gastric epithelium in the progressive stages of HP infection. The expression of proliferating cell nuclear antigen (PCNA), which has proven to be a reliable method for this evaluation, was used as a marker. The study was performed on endoscopic biopsies of the gastric antrum of 40 patients, who were divided into five groups, eight in each group: normal histology and endoscopy, HP-; histological HP+ gastritis with normal endoscopy; histological HP+ gastritis with endoscopic evidence of chronic erosions; complete and incomplete intestinal metaplasia in a HP+ stomach. PCNA was detected by immunohistochemistry and expressed as labeling index, ie, percentage of positive nuclei either in the whole or upper third of foveolae. Our data show a progressive increase of epithelial proliferation in the successive stages of HP infection ranging from gastritis alone to the development of incomplete intestinal metaplasia, a well-known precancerous condition. The proliferative pattern tended to expand towards the upper foveolar third, which in normal conditions does not represent a site of epithelial renewal. These alterations may be related to the development of neoplastic transformations of gastric epithelium. It is well known that genetic mutations are facilitated in proliferating cells. Therefore, our results indicate that the high epithelial turnover, expressed by PCNA LI, may be an indicator of increased risk of neoplastic changes in long-standing untreated HP+ chronic gastritis.
- Published
- 1996
15. Effect of oestrogen replacement on bone metabolism and cytokines in surgical menopause
- Author
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A. M. Ingrosso, Francesco Paolo Cantatore, R. Lacanna, L. Selvaggi, G Loverro, M. Carrozzo, and E. Sassanelli
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Adult ,Medroxyprogesterone ,medicine.medical_specialty ,Ovariectomy ,medicine.medical_treatment ,Osteoporosis ,Hysterectomy ,Bone and Bones ,law.invention ,Bone remodeling ,Surgical Menopause ,Pharmacotherapy ,Rheumatology ,Randomized controlled trial ,law ,Internal medicine ,Humans ,Medicine ,Amino Acids ,Osteoporosis, Postmenopausal ,Gynecology ,Estradiol ,Interleukin-6 ,business.industry ,Estrogen Replacement Therapy ,Oophorectomy ,General Medicine ,Middle Aged ,Alkaline Phosphatase ,medicine.disease ,Parathyroid Hormone ,Interleukin-2 ,Drug Therapy, Combination ,Female ,Bone Remodeling ,Menopause ,business - Abstract
The effect of oestrogen replacement on bone metabolism and serum cytokine levels (IL1,IL6) was investigated in surgical menopause. The study included 40 female subjects; 10 healthy premenopausal women underwent total hysterectomy without oophorectomy. Thirty healthy premenopausal women underwent total hysterectomy with bilateral oophorectomy. They were randomly divided into 3 groups of 10 subjects. The first group received natural estradiol (0.05 mg/day) for 6 months; the second group received natural estradiol (0.05 mg/day) and medroxyprogesteron acetate (10 mg/day) for 6 months, the third group received no therapy. Calcium-phosphorus metabolism, inflammatory indices, serum IL1 and IL6 levels were tested before and 6 months after surgery in all patients. A significant increase in serum alkaline phosphatase, urinary cross-links, serum PTH and IL1-IL6 was observed in the untreated women with total hysterectomy and oophorectomy. No significant variation in any of the parameters considered was observed in patients treated with oestrogen, in those treated with oestrogens and medroxyprogesteron nor in patients without oophorectomy. These results in human "in vivo" confirm that ovarian steroids play an important role in regulating the production of IL1 and IL6 which could regulate bone resorption.
- Published
- 1995
16. Infliximab therapy downregulation of basic fibroblast growth factor/syndecan 1 link: a possible molecular pathway of mucosal healing in ulcerative colitis
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Floriana Giorgio, S. Marangi, M. Ingrosso, Mariabeatrice Principi, Enzo Ierardi, M. Zotti, Vincenzo De Francesco, Rosa Rosania, Nicola Della Valle, Carmine Panella, and Alfredo Di Leo
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Stromal cell ,Basic fibroblast growth factor ,Anti-Inflammatory Agents ,Down-Regulation ,Gastroenterology ,Inflammatory bowel disease ,Pathology and Forensic Medicine ,Syndecan 1 ,chemistry.chemical_compound ,Gastrointestinal Agents ,Internal medicine ,medicine ,Humans ,RNA, Messenger ,Intestinal Mucosa ,Retrospective Studies ,Wound Healing ,business.industry ,Reverse Transcriptase Polymerase Chain Reaction ,Tumor Necrosis Factor-alpha ,Rectum ,Antibodies, Monoclonal ,General Medicine ,Middle Aged ,medicine.disease ,Ulcerative colitis ,Immunohistochemistry ,Infliximab ,chemistry ,Case-Control Studies ,Tumor necrosis factor alpha ,Colitis, Ulcerative ,Female ,Fibroblast Growth Factor 2 ,Syndecan-1 ,business ,medicine.drug - Abstract
It is known that syndecan 1 in inflammatory bowel diseases is able to migrate from epithelial basolateral site to the stromal area and apical surface of epithelium with a consequent activation and modulation of basic fibroblast growth factor (bFGF), and this process sustains mucosal healing of ulcers. On the other hand, tumour necrosis factor (TNF) α mucosal levels are directly related to the entity of the damage in these disorders. Aim of the study A 'post-hoc' retrospective study was performed to estimate mucosal TNF α in rectal biopsies of subjects with ulcerative colitis (UC) before and after effective infliximab therapy and its relationship with syndecan 1, bFGF and endoscopic mucosal healing.Paraffin-embedded rectal samples from 12 patients with UC responders to infliximab were analysed for TNF α, syndecan 1 and bFGF before and 6 months after therapy using a real-time reverse transcriptase polymersase chain reaction. Additionally, syndecan 1 location was evaluated by immunohistochemistry. Samples from 12 subjects with irritable bowel symptoms without endoscopic/histological abnormalities represented the control group. Mucosal healing induced by the treatment was defined by an endoscopic Mayo subscore changing from 2-3 to 0. ANOVA plus Student-Newman-Keuls was used for statistical analysis.The authors found that in the active disease, an increase in TNF α (p0.001) is accompanied by raised levels of both syndecan 1 (p0.005) and bFGF (p0.005) compared with the control group. Infliximab-induced TNF α decrease to levels similar to controls is associated with both endoscopic mucosal healing and adhesion molecule/growth factor significant reduction. Additionally, syndecan 1 location, which is predominant in the stromal cells and apical epithelium in the active disorder, is quite exclusively located at the basolateral epithelial area in both healed mucosa and controls.Balanced interaction among TNF α inhibition by infliximab, syndecan 1 migration, bFGF repair modulation and final adhesion molecule reversal to its normal location might represent a suitable molecular pathway of endoscopic mucosal healing in UC.
- Published
- 2011
17. Gastric cancer
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J. O’Callaghan, K. Nakamura, T. Tamura, R. Scelsi, G. Floretti, N. Masubuchi, F. Vianello, P. Meusers, J. C. Murphy, M. Blanco, N. Ishiyama, V. Mazzeo, E. Ierardi, S. Rizzi, R. Baffa, P. Maiolo, S. G. Xu, S. Takahashi, F. Bagnolo, Y. Tonokatsu, G. Corbett-Feeney, R. A. Monno, C. Avellini, S. Hori, A. Pisani, D. Forman, J. Pappo, T. Shimoyama, A. M. Lesseis, H. Igarashi, S. Saito, K. R. Palmer, A. Francavilla, C. F. McCarthy, M. Gaudio, J. Holton, G. Delia Libera, T. Aoyagi, Z. Kabok, I. Hirata, R. B. Zotz, F. Miglio, G. von Recklinghausen, M. Miglioli, E. Grazia, B. Germanà, F. Valiante, M. A. Eastwood, R. Bazzocchi, E. Jonghi-Lavarini, A. Casadei, D. Valpiani, L. Barbara, P. Panza, F. Farinati, H. Goebell, M. Menegatti, J. G. Fox, H. Inoue, C. A. Scott, M. A. K. Khandekar, P. Mulè, A. De Lorenzis, I. Yamamoto, T. Itoh, C. A. Beltrami, P. Webb, L. Desinan, A. Bini, M. Valenza, C. L. Little, C. Rizzi, E. Colombo, R. Fiocca, P. A. Testoni, F. Di Mario, M. Rugge, R. Gusmaroli, Y. Fukuda, and M. Ingrosso
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Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Cancer ,General Medicine ,medicine.disease ,business - Published
- 1992
18. Oral Tacrolimus (FK 506) in Crohn's Disease Complicated by Fistulae of the Perineum
- Author
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Maria Rendina, Enzo Ierardi, Antonio Pisani, Carmine Panella, M. Ingrosso, Annacinzia Amoruso, Ruggiero Francavilla, Mariabeatrice Principi, and Antonio Francavilla
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pancolitis ,Fistula ,medicine.medical_treatment ,Administration, Oral ,Perineum ,Tacrolimus ,Ileostomy ,Crohn Disease ,medicine ,Humans ,Colectomy ,Crohn's disease ,business.industry ,Gastroenterology ,medicine.disease ,Perineal fistula ,Surgery ,Parenteral nutrition ,medicine.anatomical_structure ,medicine.symptom ,business ,Immunosuppressive Agents - Abstract
We describe the cases of two patients with Crohn's disease affected by severe perineal fistulae resistant to conventional therapies, successfully treated with FK 506, a new immunomodulatory drug. It is well absorbed from diseased bowel and preliminary experiences have indicated its short-term use in complicated Crohn's disease. The first patient was a 24-year-old male with perineal fistula and severe skin ulceration (8 cm of external opening diameter). He had undergone colectomy and ileostomy because of severe pancolitis refractory to medical treatment and had been treated with azathioprine and metronidazole. Two months after starting FK 506, a dramatic improvement made further surgical operation unnecessary. Local and general benefit was observed during the following 26 months, until FK 506 was withdrawn. The second patient was a 28-year-old male with a diagnosis of ulcerative pancolitis changed to Crohn's disease two months after the onset of a perineal fistula, recurring despite drainage procedures, steroid therapy, and total parenteral nutrition. FK 506 was administered for two months with a complete healing of fistula. Successively, it was stopped and corticosteroids (associated to enteral nutrition) were given because of recurrent rectal bleeding. Our experience encourages the use of oral FK 506 in complicated Crohn's disease and suggests the possibility of a long-term primary therapy other than the use as a "bridge" to other treatments.
- Published
- 2000
19. Endoscopic gallbladder drainage for acute cholecystitis: technical and clinical results
- Author
-
V. Perri, Massimiliano Mutignani, A. Tringali, Federico Iacopini, M. Ingrosso, Guido Costamagna, Cristiano Spada, and Pietro Familiari
- Subjects
Adult ,Male ,medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,Cholecystitis, Acute ,Recurrence ,medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,Cholangiopancreatography, Endoscopic Retrograde ,Endoscopic retrograde cholangiopancreatography ,Common bile duct ,medicine.diagnostic_test ,business.industry ,Gallbladder ,Standard treatment ,Gastroenterology ,Middle Aged ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,Cholecystitis ,Cystic duct ,Feasibility Studies ,Cholecystectomy ,Female ,business - Abstract
BACKGROUND AND STUDY AIMS: Cholecystectomy is the standard treatment for acute cholecystitis while percutaneous drainage is reserved for high-risk patients. The aim of the present study was to assess the technical success rate and clinical efficacy of endoscopic gallbladder drainage in patients with acute cholecystitis. PATIENTS AND METHODS: A total of 35 consecutive patients with acute cholecystitis and without residual common bile duct obstruction were retrospectively identified. Patients were stratified according to the pathogenesis and stages of acute cholecystitis, and the morphology of the cystic duct and/or its insertion in the common bile duct. Primary outcomes were technical success and early and late clinical success. RESULTS: Endoscopic retrograde cholangiopancreatography (ERCP) was performed within the first 72 hours in 19 patients (54 %). Technical success was achieved in 29 patients (83 %); drainage was nasocholecystic in 21 ofthese (72 %), plastic stenting in 6 (21 %), and a combined method in 2 (7 %). The pathogenesis and stage of acute cholecystitis, and the morphology both of the cystic duct and its insertion in the common bile duct, did not influence technical success. Clinical success was achieved in 24 cases (83 %) after a median of 3 days (range 2 - 12). Four patients (14 %) died within 3 days due to septic complications, and one accidentally removed the nasocholecystic drain after 24 hours. Late results, available in 21 patients after a median follow-up of 17 months, showed relapse of acute cholecystitis in 2 (10 %) (both with stents) and of biliary pain in 2 patients (10 %), both of whom had nasocholecystic drainage. CONCLUSIONS: Endoscopic gallbladder drainage seems feasible and effective in resolving acute cholecystitis, but only as a temporary measure because of a 20 % relapse rate in long-term follow-up. Prospective studies are necessary to identify which patients would benefit most from this endoscopic technique in the short and long term.
- Published
- 2009
20. Femoral and sciatic nerves block (BiBlock) in orthopedic traumatologic lower limbs surgery in patients with multiple sclerosis
- Author
-
M, Ingrosso, V, Cirillo, A, Papasso, V, Merolla, and F, Cecere
- Subjects
Multiple Sclerosis ,Humans ,Accidental Falls ,Female ,Nerve Block ,Orthopedic Procedures ,Middle Aged ,Sciatic Nerve ,Femoral Nerve ,Leg Injuries - Abstract
Multiple sclerosis is a progressive demyelinating disease which affects large areas of the brain and of the spinal cord. Stressful events, surgical procedures, general anaesthesia and central blocks seem to be responsible for relapses, with worsening of the disease. So, when we scheduled 2 patients with multiple sclerosis for lower limbs orthopedic traumatologic surgery, we decided to use a peripheral block, and in particular a BiBlock. The patients' evaluation in the immediate postoperative course and 30 days after surgery has shown no relapses of the disease. In the literature, however, data about anaesthesia and multiple sclerosis are few and controversial, sometimes in contrast. Anyway, the use of peripheral blocks has neither anatomic, nor metabolic interferences with the lesion sites of multiple sclerosis. In conclusion, peripheral block is safe and it is the technique of choice for this type of patients, when surgery allows it.
- Published
- 2005
21. Anaestethic problems in Sanfilippo syndrome. A rare case of adult patient
- Author
-
M, Ingrosso, M M, Picilli, A, Capasso, F, Cecere, V, Cirillo, and V, Merolla
- Subjects
Adult ,Respiration Disorders ,Anesthesia, Spinal ,Bupivacaine ,Laryngeal Masks ,Subarachnoid Space ,Mucopolysaccharidosis III ,Ovarian Cysts ,Monitoring, Intraoperative ,Humans ,Female ,Anesthetics, Local ,Anesthesia, Inhalation ,Intraoperative Complications - Abstract
The authors report the case of a female patient (41 years old) affected by mucopolysaccharidosis type III or Sanfilippo syndrome submitted to a gynecologic surgical procedure and describe the main anesthesiologic problems. A sub-arachnoid anesthesia with hyperbaric Bupivacain 0.5% was used. This technique proved to be safe and convenient without peri- and postoperative complications.
- Published
- 2003
22. Topical butyrate improves efficacy of 5-ASA in refractory distal ulcerative colitis: results of a multicentre trial
- Author
-
P, Vernia, V, Annese, G, Bresci, G, d'Albasio, R, D'Incà, S, Giaccari, M, Ingrosso, C, Mansi, G, Riegler, D, Valpiani, and R, Caprilli
- Subjects
Adult ,Male ,Butyrates ,Double-Blind Method ,Anti-Inflammatory Agents, Non-Steroidal ,Chronic Disease ,Humans ,Colitis, Ulcerative ,Drug Therapy, Combination ,Female ,Middle Aged ,Anti-Ulcer Agents ,Mesalamine - Abstract
The treatment of distal ulcerative colitis, refractory to conventional 5-ASA/steroid treatment, is still a matter of debate. The present study aimed at confirming, with adequate statistical power, previous data indicating the usefulness of topical butyrate and 5-ASA in the treatment of this condition.Double-blind, placebo-controlled, multicentre study. A total of 51 patients with distal (65 cm) ulcerative colitis, refractory to topical 5-ASA/cortisone, were randomly allocated to receive topical 5-ASA 2 g and 80 mM L-1 sodium-butyrate bid (Group A; 24 patients) or 5-ASA 2 g and 80 mL saline bid (Group B; 27 patients) for 6 weeks. Sigmoidoscopy with biopsies, as well as clinical and laboratory evaluations, were carried out at enrollment and at the end of the trial. Primary endpoints: remission or marked improvement in endoscopic, histologic and clinical findings.Most parameters showed a significant improvement vs. baseline in both groups. Remission in six patients and improvement in 12 patients in Group A vs. one remission and 13 with improvement in Group B (P0.05). A significant difference in favour of Group A was recorded regarding the number of bowel movements (P0.01), urgency (P0.05) and the patients' self evaluation (P0.01).The combined treatment with topical butyrate and 5-ASA is significantly more effective than 5-ASA alone in the management of refractory distal colitis. Further improvements in the treatment of refractory distal ulcerative colitis may be feasible based on the identification of patient subgroups and the association of two or more active drugs. Butyrate may well be one of them.
- Published
- 2003
23. Endoscopic treatment of postsurgical external pancreatic fistulas
- Author
-
V. Vamvakousis, P. Alevras, Raffaele Manta, Guido Costamagna, M. Ingrosso, M. Mutignani, and V. Perri
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pancreatic disease ,Fistula ,Pancreatic Fistula ,Postoperative Complications ,Medicine ,Humans ,Aged ,Pancreatic duct ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Pancreatic Ducts ,Pancreatic Diseases ,Endoscopy ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Major duodenal papilla ,medicine.anatomical_structure ,Treatment Outcome ,Pancreatitis ,Chronic Disease ,Female ,business ,Pancreas ,Abdominal surgery ,Follow-Up Studies - Abstract
Background and study aims External pancreatic fistulas (EPFs) are managed primarily by conservative treatment with a success rate of 40-90%. Failures of conservative therapy have traditionally been dealt with using surgery; however, major morbidity and mortality are associated with operative treatment. The aim of this study was to evaluate the feasibility and effectiveness of endoscopic treatment in the closure of EPF. Patients and methods A total of 16 consecutive patients with EPF (12 men, four women; median age 50, range 21-66) underwent an attempt at endoscopic management after failure of conservative therapy. Four patients had chronic pancreatitis. All patients had EPFs occurring after open abdominal surgery. The mean interval between the onset of the fistula and our intervention was 108 days (range 27-365 days). The mean output volume of the fistula was 205 ml/d (range 50-600 ml/ d). The aim of treatment was to lower the pancreatic duct pressure and to bypass the ductal disruption by placement of drains and/or stents to induce fistula healing. Results In all, 13 biliary and nine pancreatic sphincterotomies were performed in order to gain access to the pancreatic duct. Access through the minor papilla was required in one patient. Complete visualization of the main pancreatic duct as well as of the fistulous tract was obtained in 12 patients (75%). Treatment consisted of placement of a nasal pancreatic drain (NPD) across the pancreaticojejunal anastomosis in one patient after duodenopancreatectomy. In 11 of the remaining 15 patients (73%) a NPD could be placed in the pancreatic duct across the ductal leakage (n = 9) or nearby (n = 2). One patient died 24 hours after endoscopic treatment from severe sepsis and massive pulmonary embolism. Endoscopic drainage was effective in healing the EPF in all patients in whom NPDs had been successfully placed, except one. The fistula in this patient healed completely after insertion of an 8.5-Fr pancreatic stent. The mean interval between endoscopic treatment and fistula closure was 8.8 days (range 2-33 days). No complications related to the endoscopic treatment were recorded in this series. In the 12 successfully treated patients, fistulas did not recur in any of the 11 surviving patients after a mean follow-up of 24.7 months (range 3-63 months). Conclusions Endoscopic pancreatic drainage, when feasible, is safe and effective for EPF and should be considered as a first-line therapy when EPFs do not respond to conservative therapy.
- Published
- 2001
24. Oral tacrolimus long-term therapy in patients with Crohn's disease and steroid resistance
- Author
-
E, Ierardi, M, Principi, R, Francavilla, A, Pisani, M, Rendina, M, Ingrosso, F W, Guglielmi, C, Panella, and A, Francavilla
- Subjects
Adult ,Male ,Drug Resistance ,Administration, Oral ,Middle Aged ,Tacrolimus ,Hospitalization ,Treatment Outcome ,Crohn Disease ,Quality of Life ,Humans ,Female ,Steroids ,Immunosuppressive Agents - Abstract
To report the results of a prospective, open-label, uncontrolled study in 13 patients affected by Crohn's disease with resistance to steroids.The patients were treated long-term with oral tacrolimus, aiming to both resolve acute attacks and maintain remission. Tacrolimus was administered at the dose of 0.1--0.2 mg.day/kg and adjusted in order to achieve levels of 5--10 ng/mL; only mesalazine was continued concomitantly. Steroids and total parenteral nutrition were tapered when appropriate.Median treatment was 27.3 months. Only one patient dropped out due to adverse events. Crohn's disease activity index score significantly decreased after 6 months in 11 patients; for 1 year in nine of them, and 7 years in two of them. The inflammatory bowel disease life-quality questionnaire score significantly increased over the same periods. A marked drop in hospitalizations was recorded. In three out of six patients complete closure of fistulas occurred. Tacrolimus allowed total parenteral nutrition to be withdrawn in three out of five patients. Supplementation with low-dose steroids was required in five patients. Two patients underwent surgery.Tacrolimus therapy appears to be associated with both short- and long-term benefits, and may represent a therapeutic option in Crohn's disease when conventional therapies fail. This study encourages its use in controlled trials.
- Published
- 2001
25. Age-related clinical severity at diagnosis in 1705 patients with ulcerative colitis: a study by GISC (Italian Colon-Rectum Study Group)
- Author
-
G, Riegler, M T, Tartaglione, R, Carratú, R, D'Incá, D, Valpiani, M I, Russo, C, Papi, M T, Fiorentini, M, Ingrosso, A, Andreoli, M, Vecchi, Riegler, Gabriele, Tartaglione, Mt, Carratu, R, D'Inca, R, Valpiani, D, Russo, Mi, Papi, C, Fiorentini, Mt, Ingrosso, M, Andreoli, A, and Vecchi, M.
- Subjects
Adult ,Male ,Sex Factors ,Risk Factors ,Smoking ,Age Factors ,Humans ,Colitis, Ulcerative ,Female - Abstract
Clinical-endoscopic parameters of UC presentation were studied in 1705 out-patients, observed consecutively in 17 Italian gastroenterology centers (males 60.2%; average age at diagnosis 38.5 +/- 16.4 years), and were subdivided arbitrarily into quartile age groups at diagnosis (0-25, 26-35, 36-50,50). A significantly greater prevalence in males, increasing with age, was shown at diagnosis (P = 0.0002), which seems to correlate with the condition of being an ex-smoker, most frequently found in males. The greater frequency of exsmokers could also, in part, justify the second peak of incidence in old age. Greater colitis extent, greater clinical activity, and greater use of steroids as the first therapeutic step are shown to prevail among younger patients and among women (P = 0.02 and P = 0.019, respectively). The same is observed for symptoms mainly representing clinical severity such as diarrhea, fever, and weight loss (P = 0.004; P = 0.006; P = 0.009, respectively). This study confirms the UC risk factor represented by the condition of being an ex-smoker and shows a greater severity of illness on diagnosis in younger patients.
- Published
- 2000
26. Laparoscopically assisted total enteroscopy: a new approach to small intestinal diseases
- Author
-
Antonio Francavilla, Alessandro Azzarone, Antonio Pisani, Fernando Prete, Rosa Carbonara, and M. Ingrosso
- Subjects
Surgical resection ,Enteroscopy ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Endoscopy, Gastrointestinal ,Angioma ,Text mining ,Laparotomy ,medicine ,Humans ,Minimally Invasive Surgical Procedures ,Radiology, Nuclear Medicine and imaging ,medicine.diagnostic_test ,Vascular disease ,business.industry ,General surgery ,Gastroenterology ,medicine.disease ,Laparoscopes ,Surgery ,Endoscopy ,Endoscopes, Gastrointestinal ,Ileal Neoplasms ,Chronic Disease ,Laparoscopy ,business ,Gastrointestinal Hemorrhage ,Hemangioma - Published
- 1999
27. PO.69 A QUANTITATIVE METHOD TO ASSESS GUIDEWIRES FRICTION FOR GASTROINTESTINAL ENDOSCOPY
- Author
-
G. Spera, M. Ingrosso, G. Contini, and M. Pantaleone
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,Gastroenterology ,Medicine ,Radiology ,business ,Gastrointestinal endoscopy - Published
- 2008
28. STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer
- Author
-
N, Resta, C, Simone, C, Mareni, M, Montera, M, Gentile, F, Susca, R, Gristina, S, Pozzi, L, Bertario, P, Bufo, N, Carlomagno, M, Ingrosso, F P, Rossini, R, Tenconi, and G, Guanti
- Subjects
AMP-Activated Protein Kinase Kinases ,Mutation ,Peutz-Jeghers Syndrome ,Humans ,Loss of Heterozygosity ,Genes, Tumor Suppressor ,Protein Serine-Threonine Kinases ,Colorectal Neoplasms - Abstract
A potential tumor suppressor gene, STK11 , encoding a serine threonine kinase, has recently been identified on chromosome 19p13. Germ-line mutations of this gene have been found in patients with Peutz-Jeghers syndrome (PJS). To further investigate the relevance of STK11 mutations in PJS, we analyzed its coding sequence in nine patients and identified two deletions and three missense mutations. Because intestinal carcinomas have been observed to develop in association with PJS, we analyzed tumors from 71 patients for allelic deletions (loss of heterozygosity) and STK11 gene mutations, to elucidate the etiological role of STK11 gene in sporadic colorectal cancer. Loss of heterozygosity, evaluated using the microsatellite D19S886, was observed in 10 of 52 informative cases. No somatic mutations were detected except for a missense alteration in one tumor. Our data indicate the heterogeneity of PJS and the infrequent involvement of the STK11 gene in colorectal cancer.
- Published
- 1998
29. Hepatobiliary alterations in patients with inflammatory bowel disease: a multicenter study. Caprilli & Gruppo Italiano Studio Colon-Retto
- Author
-
G, Riegler, R, D'Incà, G C, Sturniolo, G, Corrao, C, Del Vecchio Blanco, V, Di Leo, R, Carratù, M, Ingrosso, M A, Pelli, S, Morini, D, Valpiani, D, Cantarini, P, Usai, C, Papi, R, Caprilli, Riegler, Gabriele, D'Inca, R, Sturniolo, Gc, Corrao, G, DEL VECCHIO BLANCO, C, DI LEO, V, Carratu, R, Ingrosso, M, Pelli, Ma, Morini, S, Valpiani, D, Cantarini, D, Usai, P, Papi, C, Caprilli, R., Riegler, G, D'Incà, R, Sturniolo, G, Del Vecchio Blanco, C, Di Leo, V, Carratù, R, Pelli, M, and Caprilli, R
- Subjects
Adult ,Aged, 80 and over ,Male ,Adolescent ,Biliary Tract Diseases ,Liver Diseases ,hepatobiliary alterations ,Middle Aged ,Crohn Disease ,inflammatory bowel disease ,Humans ,Colitis, Ulcerative ,Female ,Child ,Aged - Abstract
BACKGROUND AND METHODS: Four hundred and eighty-four patients with inflammatory bowel disease underwent clinical examination, ultrasonography, and biochemical liver function tests, to estimate the prevalence of hepatobiliary alterations. The patient group included patients without a history of liver disease. Controls were recruited from patients with functional symptoms. RESULTS: More patients with ulcerative colitis than controls had liver steatosis and increased alkaline phosphatase levels. Factors increasing the probability of liver damage were long-standing disease, the presence of moderate/severe disease activity, and treatment with steroids and mesalazine. A significant association was found between biliary disease and long-standing colitis and also therapy with steroids and mesalazine. Alkaline phosphatase and aminotransferase levels were significantly higher in Crohn's disease patients than in controls. Hepatic and biliary damage was found more commonly in the 1st year after diagnosis. CONCLUSIONS: The monitoring of hepatobiliary function is suggested for patients with inflammatory bowel disease, even in the absence of symptoms and history
- Published
- 1998
30. Effect of Helicobacter pylori eradication on gastric epithelial proliferation. Relationship with ras oncogene p21 expression
- Author
-
E, Ierardi, A, Francavilla, T, Balzano, A, Traversa, M, Principi, R A, Monno, A, Amoruso, M, Ingrosso, A, Pisani, and C, Panella
- Subjects
Adult ,Male ,Metaplasia ,Helicobacter pylori ,Middle Aged ,Immunohistochemistry ,Helicobacter Infections ,Intestines ,Proto-Oncogene Proteins p21(ras) ,Cell Transformation, Neoplastic ,Gastric Mucosa ,Stomach Neoplasms ,Gastritis ,Proliferating Cell Nuclear Antigen ,Humans ,Female ,Intestinal Mucosa ,Cell Division ,Aged ,Retrospective Studies - Abstract
Impaired changes in gastric epithelium proliferation have been described in Helicobacter pylori infection, and a progressive increase of proliferating cells has been shown with the progression of mucosal lesions.Purpose of this investigation was to study the effect of eradication on bacterium-induced proliferative changes, evaluated by the proliferating cell nuclear antigen labelling index (PCNA LI) and its relationship to the ras oncoprotein p21, involved in early events of gastric carcinogenesis.This retrospective study was performed, before and after therapy, in five different groups of patients with progressive stages of Helicobacter pylori damage (N: normality; HG: histological gastritis with normal endoscopy; EHG: histological gastritis with endoscopic chronic erosions; CIM: complete intestinal metaplasia; IIM: incomplete intestinal metaplasia).Six months after eradication, a normalization of PCNA LI was observed in the areas of gastritis, but not in those of intestinal metaplasia, which showed on unchanged type. Moreover, immunohistochemical membrane expression of ras oncoprotein p21 was only associated to intestinal metaplasia. The protein was also expressed in the cytoplasm in 3 patients with incomplete type.These results suggest that the development of intestinal metaplasia may be associated with an alteration in the control of gastric epithelium proliferation and could represent an initial stage in gastric carcinogenesis. Nevertheless, further genetic changes are necessary for a complete progression to neoplastic disease. A long-term follow-up on extension, type, proliferative situation and oncoprotein expression in areas of intestinal metaplasia may be helpful to explain whether the present data provide new information on the mechanism of Helicobacter pylori induced gastric carcinogenesis.
- Published
- 1997
31. Pachydermoperiostosis: dermatological, neurological and radiological observations
- Author
-
M. Carrozzo, Francesco Paolo Cantatore, A. M. Ingrosso, and L. Mancini
- Subjects
Adult ,Male ,medicine.medical_specialty ,Achilles tendon ,Osteoarthropathy, Primary Hypertrophic ,business.industry ,General Medicine ,medicine.disease ,Hypertrophic osteoarthropathy ,Rheumatology ,Surgery ,body regions ,Radiography ,Stenosis ,medicine.anatomical_structure ,Internal medicine ,Radiological weapon ,medicine ,Periosteal apposition ,Humans ,Tarsal tunnel ,business ,Calcification - Abstract
A case of pachydermoperiostosis is described. Interesting features were the presence of carpal and tarsal tunnel syndromes, chronic leg ulcerations and large calcification of the Achilles tendon. Neurological alterations were explained by the stenosis of the tunnels secondary to the periosteal apposition. Chronic leg ulcerations were probably due to neurological and circulatory alterations.
- Published
- 1995
32. P.1.341: A NEW REGIMEN OF BOWEL PREPARATION FOR PILLCAM COLON CAPSULE ENDOSCOPY: A PILOT STUDY
- Author
-
C. Spada, C. Hassan, M. Ingrosso, A. Simone, M.E. Riccioni, M. Pennazio, P. Pirozzi, N. Pagano, P. Cesaro, G. Spera, L. Petruzziello, and G. Costamagna
- Subjects
Hepatology ,Gastroenterology - Published
- 2011
33. Helicobacter pylori and chronic antral erosions: our experience
- Author
-
E, Ierardi, A, Mongelli, R A, Monno, M, Ingrosso, A, Pisani, D, Fumarola, and A, Francavilla
- Subjects
Helicobacter pylori ,Italy ,Gastritis ,Chronic Disease ,Humans ,Helicobacter Infections - Published
- 1990
34. 21 P Duodenal gastrointestinal stromal tumor (GIST): Case reports
- Author
-
Antonio Pisani, A. Francavilla, B. Principi, A. Panarese, G. Rizzo, M. Ingrosso, M. Gambato, and Domenico Piscitelli
- Subjects
Pathology ,medicine.medical_specialty ,Hepatology ,GiST ,business.industry ,Gastroenterology ,Medicine ,Stromal tumor ,business - Published
- 2002
35. Transjugular intrahepatic porto-systemic shunt (TIPS) in a case of recurrent bleeding from gastric antral vascular ectasia (GAVE) after liver transplantation (LT)
- Author
-
A. Castellaneta, Maria Rendina, Antonio Pisani, A. Francavilla, and M. Ingrosso
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,medicine.medical_treatment ,Gastroenterology ,Gastric antral vascular ectasia ,Liver transplantation ,medicine.disease ,Surgery ,Shunt (medical) ,medicine ,Recurrent bleeding ,Radiology ,business - Published
- 2001
36. Intraoperative enteroscopy (IOE) in gastrointestinal (GI) bleeding: Our experience
- Author
-
Mariabeatrice Principi, Antonio Pisani, A. Francavilla, and M. Ingrosso
- Subjects
medicine.medical_specialty ,Hepatology ,GI bleeding ,business.industry ,Gastroenterology ,Medicine ,Intraoperative enteroscopy ,business ,Surgery - Published
- 2001
37. Endosonography (EUS) and conservative management of gastric malt lymphoma (GML)
- Author
-
V. Liso, Antonio Pisani, A. Francavila, Mariabeatrice Principi, M. Ingrosso, and V. Pavone
- Subjects
medicine.medical_specialty ,Gastric MALT Lymphoma ,Hepatology ,Conservative management ,business.industry ,Internal medicine ,Gastroenterology ,medicine ,business - Published
- 2001
38. Epithelial proliferation and ras p21 oncoprotein in the rectum of patients with ulcerative colitis
- Author
-
Mariabeatrice Principi, Antonio Pisani, A. Francavilla, Enzo Ierardi, O. Burattini, F. Noviello, and M. Ingrosso
- Subjects
medicine.anatomical_structure ,Hepatology ,business.industry ,Gastroenterology ,Cancer research ,Medicine ,Rectum ,Epithelial proliferation ,business ,medicine.disease ,Ulcerative colitis - Published
- 2000
39. May a failure of the therapy with anti-TNFα (infliximab) reveal a misdiagnosis of Crohn's disease?
- Author
-
Enzo Ierardi, O. Burattini, M. Ingrosso, Antonio Pisani, Mariabeatrice Principi, A. Francavilla, and Carmine Panella
- Subjects
medicine.medical_specialty ,Crohn's disease ,Hepatology ,business.industry ,Internal medicine ,Gastroenterology ,medicine ,Tumor necrosis factor alpha ,business ,medicine.disease ,Infliximab ,medicine.drug - Published
- 2000
40. Abord diagnostique de la surveillance des anastomoses iléo-coliques dans la maladie de Crohn
- Author
-
F. Scevola, M. Ingrosso, S. Coverlizza, A. Ferrari, F. P. Rossini, P. Luparia, M. Spandre, and M. Cavallero
- Subjects
Gynecology ,Surgical anastomosis ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Crohn disease ,Medicine ,Radiology, Nuclear Medicine and imaging ,Interventional radiology ,business ,Hemicolectomy ,Abdominal surgery ,Endoscopy - Abstract
L'etude presentee a pour but d'evaluer la valeur l'efficacite et la credibilite des differentes methodes de diagnostic (donnees cliniques, tests de laboratoire, examens radiographiques et endoscopiques) dans la surveillance de patients soumis a une resection intestinale pour maladie de Crohn et porteurs d'une anastomose ileo-colique.
- Published
- 1983
41. Effect of cimetidine, ranitidine, famotidine and omeprazole on hepatocyte proliferation in vitro
- Author
-
Lorenzo Polimeno, Thomas E. Starzl, Michele Barone, Leonard Makowka, Carmine Panella, Antonio Francavilla, A. Di Leo, Annacinzia Amoruso, and M. Ingrosso
- Subjects
medicine.medical_specialty ,Ranitidine ,Article ,Transaminase ,Histamine H2 receptor ,Internal medicine ,medicine ,Animals ,Hepatectomy ,Cimetidine ,Cells, Cultured ,Omeprazole ,Hepatology ,DNA synthesis ,business.industry ,Osmolar Concentration ,DNA ,Famotidine ,Hormones ,Rats, Inbred F344 ,Rats ,Thiazoles ,Endocrinology ,medicine.anatomical_structure ,Histamine H2 Antagonists ,Liver ,Hepatocyte ,business ,Cell Division ,medicine.drug - Abstract
Recently reports have indicated that both cimetidine and ranitidine delay cell proliferation in rats following 70% partial hepatectomy and result in an increased mortality following this procedure. The present study was designed to determine whether three H2 blocking agents (cimetidine, ranitidine, famotidine) and a new, powerful antisecretory drug (omeprazole) specifically influence hepatocyte proliferation in primary culture. Hepatocytes were isolated from livers of normal male rats by the standard collagenase perfusion technique. Hepatic DNA synthesis and percent of labelled nuclei were determined after 48 h incubation. Hepatocytes in culture were incubated with the H2 blocking agents and omeprazole or with different concentrations of serum obtained from sham-operated or 70% hepatectomized rats treated or not with the same agents. Rats were injected intraperitoneally at 8:00 a.m. on two consecutive days. In hepatectomized rats, the first dose was injected at 8:00 a.m. immediately after surgery, the second, 24 h later. The serum of sham-operated or 70% hepatectomized rats that did not receive drugs served as control. No changes in DNA synthesis, percentage of labelled nuclei and transaminase were detected when the agents were added to the hepatocytes in culture at concentrations within the effective pharmacological dosage and 30 times higher. Similarly, no changes in these parameters were obtained when different concentrations of serum obtained from sham-operated rats treated with H2 blocking agents or omeprazole were added to the basal culture medium. However, a significant inhibition of DNA synthesis and of percentage of labelled nuclei was observed when hepatocytes were incubated in the presence of serum from 70% hepatectomized rats that had been treated with cimetidine or with ranitidine. The serum of 70% hepatectomized rats treated with famotidine and omeprazole had no effect on hepatocyte proliferation in vitro. No effect on transaminase was found in these conditions.
- Published
- 1989
42. [Indications and advantages of low colorectal anastomosis using the Dubois colorectal V-plasty]
- Author
-
R, Bocchetti, M, Ingrosso, P, Brignola, and V, Vallefuoco
- Subjects
Male ,Sigmoid Neoplasms ,Surgical Staplers ,Colon ,Rectal Neoplasms ,Methods ,Rectum ,Humans ,Female ,Middle Aged - Published
- 1985
43. [Hemorrhage from an ulcer of the posterior duodenal wall]
- Author
-
M, Ingrosso, R, Bocchetti, A, Mastrominico, and V, Vallefuoco
- Subjects
Male ,Peptic Ulcer Hemorrhage ,Time Factors ,Duodenal Ulcer ,Humans ,Female ,Emergencies ,Middle Aged ,Prognosis ,Hemostasis, Surgical - Published
- 1986
44. [Behavior of the pressure of the lower esophageal sphincter after intravenous administration of domperidone in normal subjects]
- Author
-
N, Di Martino, M, Ingrosso, L, Fei, V, Maffettone, V, Landolfi, and A, Del Genio
- Subjects
Adult ,Male ,Manometry ,Injections, Intravenous ,Pressure ,Humans ,Female ,Esophagogastric Junction ,Esophagitis, Peptic ,Domperidone - Abstract
Manometric studies on the action of domperidone 10 mg and 20 mg i.v. on the lower esophageal sphincter pressure (LESP) have been carried on ten healthy volunteers. Domperidone inhibits dopamine receptors and results in an increase of LESP. A dose of 10 mg produces a significant increase in LESP which is rapid and prolonged for thirty minutes; a dose of 20 mg is less efficient. The stimulatory effect of domperidone on LESP suggests an important role for endogenous dopamine as an inhibitory neuromodulator of LES pressure. The use of domperidone in therapy for reflux esophagitis is suggested.
- Published
- 1985
45. [The Italian pilot experience with omeprazole. Preliminary pharmacologic and clinical results]
- Author
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G, Bertaccini, M, Cisternino, G, Coruzzi, A, Francavilla, M, Gallazzi, M, Ingrosso, G, Labò, M, Rinetti, R, Sivelli, and P, Tomassetti
- Subjects
Adult ,Male ,Clinical Trials as Topic ,Pilot Projects ,Middle Aged ,Gastric Acid ,Italy ,Duodenal Ulcer ,Drug Evaluation ,Humans ,Female ,Stomach Ulcer ,Omeprazole ,Aged - Published
- 1987
46. Circadian Rhythm of Hepatic Cytosolic and Nuclear Estrogen and Androgen Receptors
- Author
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L Polimeno, A. Maria Aquilino, Alfredo DiLeo, Patricia K. Eagon, David H. Van Thiel, A. Francavilla, Carmine Panella, Thomas E. Starzl, M. Ingrosso, and Cinzia Amoruso
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,Period (gene) ,Estrogen receptor ,Biology ,Article ,Cytosol ,Internal medicine ,medicine ,Animals ,Circadian rhythm ,Receptor ,Cell Nucleus ,Hepatology ,Gastroenterology ,Estrogens ,Rats, Inbred Strains ,Sex hormone receptor ,Circadian Rhythm ,Rats ,Androgen receptor ,Endocrinology ,Liver ,Receptors, Estrogen ,Estrogen ,Receptors, Androgen ,Androgens ,Hormone - Abstract
Mammalian liver is a sex steroid-responsive tissue. The effects of these hormones presumably are mediated by hepatic estrogen receptors (ER) and androgen receptors (AR). Serum levels of sex hormones display circadian rhythms. Further, estrogens and androgens are commonly administered; administration of these agents is associated frequently with liver disease. Therefore, we investigated whether the cytosolic and nuclear sex steroid receptors also display a similar circadian rhythm, and whether variations occurred in the distribution of receptors between cytosolic and nuclear compartments. Animals were killed every 4 h from midnight till the following midnight; cytosolic and nuclear levels of both ER and AR were measured. Cytosolic ER reached a maximum level at 4 AM, and a minimum at 8 PM and midnight of both days. Nuclear ER was highest at 8 AM and lowest at 4 PM and 8 PM, a pattern which parallels variations in serum estradiol levels. Cytosolic AR was highest at 8 PM and lowest at midnight and 4 AM. Nuclear AR was highest at 4 AM and lowest at 4 PM and 8 PM. The highest level of nuclear AR does not correspond to the maximum serum testosterone level, which occurred at 4 PM. The total hepatic content of both ER and AR was not constant over the 24-h period, but varied considerably with time of day. These studies suggest that both ER and AR show a distinct circadian rhythm in subcellular compartmentalization, and that total hepatic content of ER and AR varies significantly during a 24-h period.
- Published
- 1986
47. Sex hormone-related functions in regenerating male rat liver
- Author
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David H. Van Thiel, Patricia K. Eagon, Carmine Panella, Lorenzo Polimeno, Alfredo DiLeo, Thomas E. Starzl, M. Ingrosso, Antonio Francavilla, and A. Maria Aquilino
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Estrogen receptor ,Biology ,Article ,Sex hormone-binding globulin ,Internal medicine ,medicine ,Animals ,Hepatectomy ,Hepatology ,Gastroenterology ,Rats, Inbred Strains ,Sex hormone receptor ,Liver regeneration ,Liver Regeneration ,Rats ,Androgen receptor ,Endocrinology ,Liver ,Receptors, Estrogen ,Estrogen ,Receptors, Androgen ,biology.protein ,Androgens ,Liver function - Abstract
Sex hormone receptors were quantitated in normal male rat liver and in regenerating liver at several different times after partial (70%) hepatectomy. Both estrogen and androgen receptor content were altered dramatically by partial hepatectomy. Total hepatic content and nuclear retention of estrogen receptors increased, with the zenith evident 2 days after partial hepatectomy, corresponding to the zenith of mitotic index. Serum estradiol increased after 1 day, and reached a maximum at 3 days after surgery. In contrast, total and nuclear androgen receptor content demonstrated a massive decline at 1, 2, and 3 days after resection. Serum testosterone displayed a parallel decline. In addition, hepatic content of two androgen-responsive proteins was reduced to 15% and 13% of normal values during this period. The activity of these various proteins during regeneration of male rat liver is comparable to that observed in the liver of normal female rats. Taken together, these results indicate that partial hepatectomy induces a feminization of certain sexually dimorphic aspects of liver function in male rats. Furthermore, these data provide evidence that estrogens, but not androgens, may have an important role in the process of liver regeneration.
- Published
- 1986
48. Salutogenesi e medicine complementari-alternative. Quale relazione in tempo di crisi economica
- Author
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Tognetti M., M. Ingrosso, P. Perucci, M. Tognetti Bordogna, A. Spinsanti, M. Ingrosso, P. Perucci, and Tognetti, M.
- Subjects
salute, malattia, medicine non convenzionali, crisi economica, sistema sanitario - Abstract
Il testo tratta dei concetti di salutogenesi e come questi vengono applicati nell'ambito delle medicine tradizionali e non convenzionali
- Published
- 2019
49. Gli aiuti a finalità regionale tra autonomia statutaria, solidarietà e libero mercato
- Author
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LA SCALA, Agostino Ennio, M. Ingrosso e G. Tesauro, and LA SCALA, AE
- Subjects
Aiuti a finalità regionale ,Settore IUS/12 - Diritto Tributario - Abstract
Il divieto di aiuti di Stato nell'ambito del diritto comunitario trova giustificazione sui principi di neutralità fiscale e di non discriminazione (diretta e "a rovescio"). Lo stesso diritto primario dell'Unione riconosce, tuttavia, la presenza di notevoli differenze in termini di sviluppo socio-economico tra le diverse regioni e , in un'ottica solidarista, consent importanti deroghe, pur mantenendo uno stretto controllo sulla valutazione delle agevolazioni predisposte dagli Stati membri.
- Published
- 2009
50. Le misure di sostegno in materia di navigazione marittima:l'istituzione del Registro internazionale e la 'Tonnage tax'
- Author
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NOCERINO, Ottavio, AA.VV., M. Ingrosso e G. Tesauro (a cura di), and Nocerino, Ottavio
- Subjects
Aiuti di Stato ,Imprese di navigazione marittima Registro internazionale Tonnage tax - Abstract
Il ruolo centrale rivestito dallo shipping nel settore del commercio internazionale, in uno con il leculiare carattere transnazionale delle compagnie di navigazione, ha reso particolarmente avvertita la problematica della localizzazione del reddito prodotto attraverso l'impiego di flotte su rotte internazionali. L'estrema mobilità sul piano transnazionale ha ingenerato il fenomeno delle cd. "Bandiere ombra" da parte di alcuni Stati le cui legislazioni offrono misure di particolare favore in relazione agli obblighi di carattere fiscale, sociale e previdenziale per le navi iscritte nei propri registri. La presenza di siffatti regimi ha innegabilmente ingenerato significative turbative al mercato internazionale dei noli e dunque nei rapporti concorrenziali tra le imprese impegnate nel particolare settore. L'intendimento di ripristinare la flotta mercantile ha dunque determinato, all'interno della Comunità, il progressivo affermarsi di un clima particolarmente propenso alla giustificazione dell'introduzione di misure incentivanti a favore delle imprese armatoriali; sicché la Commissione, attraverso le sue Comunicazioni, ha a più riprese manifestamente dichiarato la compatibilità con l'interesse comunitario di interventi di sostegno da parte dei singoli Stati membri, sempreché tali misure di favore rientrino entro schemi predeterminati e convergenti al fine di assicurare una sostanziale uniformità e standardizzazione degli aiuti concessi al particolare settore da parte dei vari Stati (affermazione del principio di omogeneità). Le misure di sostegno settoriale adottate dallo Stato italiano consistono nell'isiottuzione del Registro navale internzaionale (ad opera del DL 30 dicembre 1997 n. 457 conv con L. 27 febbraio 1998, n. 30) e la successiva introduzione (ad opera del DLgs. 344/2003) della cd. Tonnage tax consistente in un regime opzionale per la determinazione del reddito imponibile in funzione del tonnellaggio di stazza delle navi coinvolte. I successivi sviluppi del lavoro sono incentrati sulla descrizione dei presupposti e contenuti delle richiamate misure di favore una volta descritte le quali il fuoco dell'indagine si sposta sull'analisi dei rapporti intecorrenti tra queste.
- Published
- 2009
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