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Effect of oestrogen replacement on bone metabolism and cytokines in surgical menopause
- Source :
- Clinical Rheumatology. 14:157-160
- Publication Year :
- 1995
- Publisher :
- Springer Science and Business Media LLC, 1995.
-
Abstract
- The effect of oestrogen replacement on bone metabolism and serum cytokine levels (IL1,IL6) was investigated in surgical menopause. The study included 40 female subjects; 10 healthy premenopausal women underwent total hysterectomy without oophorectomy. Thirty healthy premenopausal women underwent total hysterectomy with bilateral oophorectomy. They were randomly divided into 3 groups of 10 subjects. The first group received natural estradiol (0.05 mg/day) for 6 months; the second group received natural estradiol (0.05 mg/day) and medroxyprogesteron acetate (10 mg/day) for 6 months, the third group received no therapy. Calcium-phosphorus metabolism, inflammatory indices, serum IL1 and IL6 levels were tested before and 6 months after surgery in all patients. A significant increase in serum alkaline phosphatase, urinary cross-links, serum PTH and IL1-IL6 was observed in the untreated women with total hysterectomy and oophorectomy. No significant variation in any of the parameters considered was observed in patients treated with oestrogen, in those treated with oestrogens and medroxyprogesteron nor in patients without oophorectomy. These results in human "in vivo" confirm that ovarian steroids play an important role in regulating the production of IL1 and IL6 which could regulate bone resorption.
- Subjects :
- Adult
Medroxyprogesterone
medicine.medical_specialty
Ovariectomy
medicine.medical_treatment
Osteoporosis
Hysterectomy
Bone and Bones
law.invention
Bone remodeling
Surgical Menopause
Pharmacotherapy
Rheumatology
Randomized controlled trial
law
Internal medicine
Humans
Medicine
Amino Acids
Osteoporosis, Postmenopausal
Gynecology
Estradiol
Interleukin-6
business.industry
Estrogen Replacement Therapy
Oophorectomy
General Medicine
Middle Aged
Alkaline Phosphatase
medicine.disease
Parathyroid Hormone
Interleukin-2
Drug Therapy, Combination
Female
Bone Remodeling
Menopause
business
Subjects
Details
- ISSN :
- 14349949 and 07703198
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Clinical Rheumatology
- Accession number :
- edsair.doi.dedup.....ba39675d20a7f019ad29c90a80b234c4