1,157 results on '"Lee, Ly"'
Search Results
2. Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy
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You, Yi, Tian, Yu, Yang, Zhaogang, Shi, Junfeng, Kwak, Kwang Joo, Tong, Yuhao, Estania, Andreanne Poppy, Cao, Jianhong, Hsu, Wei-Hsiang, Liu, Yutong, Chiang, Chi-Ling, Schrank, Benjamin R., Huntoon, Kristin, Lee, DaeYong, Li, Ziwei, Zhao, Yarong, Zhang, Huan, Gallup, Thomas D., Ha, JongHoon, Dong, Shiyan, Li, Xuefeng, Wang, Yifan, Lu, Wen-Jing, Bahrani, Eman, Lee, Ly James, Teng, Lesheng, Jiang, Wen, Lan, Feng, Kim, Betty Y. S., and Lee, Andrew S.
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- 2023
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3. Establishing Quality of Life in Southern Taiwan COPD Patients Using Long-Acting Bronchodilator
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Chin PQ, Sheu CC, Tsai JR, Chang HL, Lee LY, and Chen CY
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chronic obstructive pulmonary disease ,long-acting bronchodilators ,health-related quality of life ,risk factors ,taiwan ,Medicine (General) ,R5-920 - Abstract
Pik-Qi Chin,1,* Chau-Chyun Sheu,2,3 Jong-Rung Tsai,4,5 Hsu-Liang Chang,6 Li-Yao Lee,7,* Chung-Yu Chen1,7,8 1Master Program in Clinical Pharmacy, School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 3Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 4Division of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 5Department of Internal Medicine, Kaohsiung Municipal Cijin Hospital, Kaohsiung, Taiwan; 6Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital; Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 7Department of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 8Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan*These authors contributed equally to this workCorrespondence: Chung-Yu Chen, Master Program in Clinical Pharmacy, School of Pharmacy, Kaohsiung Medical University, No. 100, Shihcyuan 1st Road, Sanmin District, Kaohsiung, 80708, Taiwan, Tel +886-7-3121101 ext 2375, Fax +886-7-3210683, Email jk2975525@hotmail.comBackground: To assess the health-related quality of life (HRQoL) of Taiwan patients with different stages of chronic obstructive pulmonary disease (COPD) and using different combination therapies and to explore the factors affecting HRQoL in these patients.Methods: This cross-sectional study included outpatient participants aged 35 years old and older who were receiving long-acting bronchodilator treatment in one of two hospitals in Southern Taiwan. Participants were categorized according to their Global Initiative for Obstructive Lung Disease (GOLD) classification as either their COPD group, based on symptoms and exacerbation risk, or their COPD stage, based on spirometry results. Patients’ HRQoL was assessed using the St. George’s Respiratory Questionnaire score (SGRQ), World Health Organization Quality of Life Quality of Life-BREF (WHOQOL-BREF), and EQ-5D-5L. The total scores of the SGRQ, WHOQOL-BREF, EQ-5D utility index, and EQ-VAS were presented as mean ± standard deviation (SD) among different combination treatments. Univariate and multivariate analyses were used to explore the association of patients’ baseline characteristics and environmental factors with HRQoL.Results: A total of 218 patients were enrolled in the study. The distribution of patients using GOLD group classification were as follows: 73.39% in group A, 20.19% group B, 1.83% group C and 4.59% group D. Triple therapy patients mostly showed a lower quality of life than other combination therapies, regardless of the GOLD classification system. However, only the SGRQ scores of GOLD groups A and B were significantly different when using different drug combinations (p-value = 0.0072 and 0.0430, respectively). The COPD assessment test (CAT) score, a questionnaire to assess impact of COPD on health status, was found to be associated with all the questionnaires.Conclusion: The HRQoL is impaired in patients with COPD, and it deteriorates with an increase of severity. The CAT was the strongest predictor of HRQoL.Keywords: chronic obstructive pulmonary disease, long-acting bronchodilators, health-related quality of life, risk factors, Taiwan
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- 2022
4. Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus
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Chang YS, Lee LY, and Lee IT
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ankle-brachial index ,arterial stiffness ,lower extremity arterial disease ,percentage of the mean arterial pressure ,standard deviation ,Specialties of internal medicine ,RC581-951 - Abstract
Yu-Shan Chang,1,2 Liang-Yi Lee,3 I-Te Lee1,2,4 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung City, Taiwan; 3Mingdao High School, Taichung City, Taiwan; 4School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCorrespondence: I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Taichung City, 40705, TaiwanEmail itlee@vghtc.gov.twPurpose: High glucose concentrations and swings are associated with endothelial dysfunction. We examined the effects of variability in fasting plasma glucose on peripheral artery disease (PAD) in patients with diabetes mellitus (DM).Patients and Methods: In this screening study for the risk factors of PAD, we retrospectively collected data on the ankle-brachial index (ABI) and the percentage of mean arterial pressure (%MAP) at the ankle between August 01, 2016 and July 31, 2017. We defined low ABI ≤ 0.90, high %MAP ≥ 45%, or both as high-risk PAD and others as low-risk PAD. We compared the standard deviation (SD) of the first fasting plasma glucose data available each year after January 01, 2007.Results: In 2577 patients, a higher SD of annual fasting glucose was observed in those with an ABI ≤ 0.90 than in patients with an ABI > 0.90 (2.6 ± 2.1 vs 2.2 ± 2.3, P = 0.009), and in patients with %MAP ≥ 45% than in those with %MAP < 45% (2.4 ± 2.1 vs 2.2 ± 2.3, P = 0.034). A high-risk PAD was significantly associated with the SD (P = 0.032) but not with the mean (P = 0.338) of annual fasting glucose. The former was an independent risk factor for high-risk PAD (odds ratio = 1.424; 95% CI = 1.118‒1.814; P = 0.004).Conclusion: Variability but not mean of annual fasting plasma glucose was significantly associated with a high risk of PAD in patients with DM.Keywords: ankle-brachial index, arterial stiffness, lower extremity arterial disease, percentage of the mean arterial pressure, standard deviation
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- 2021
5. Exosomal mRNAs for Angiogenic–Osteogenic Coupled Bone Repair
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Ma, Yifan, primary, Sun, Lili, additional, Zhang, Jingjing, additional, Chiang, Chi‐ling, additional, Pan, Junjie, additional, Wang, Xinyu, additional, Kwak, Kwang Joo, additional, Li, Hong, additional, Zhao, Renliang, additional, Rima, Xilal Y., additional, Zhang, Chi, additional, Zhang, Anan, additional, Liu, Yutong, additional, He, Zirui, additional, Hansford, Derek, additional, Reategui, Eduardo, additional, Liu, Changsheng, additional, Lee, Andrew S., additional, Yuan, Yuan, additional, and Lee, Ly James, additional
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- 2023
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6. Overhang molecular beacons encapsulated in tethered cationic lipoplex nanoparticles for detection of single-point mutation in extracellular vesicle-associated RNAs
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Hu, Jiaming, Kwak, Kwang Joo, Shi, Junfeng, Yu, Bohao, Sheng, Yan, and Lee, Ly James
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- 2018
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7. Characteristics of individuals who frequently use emergency departments in Hong Kong: a region-based cohort study
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Ng, Peter YT, primary, Lui, CT, additional, Lau, CL, additional, Fung, HT, additional, Lai, CH, additional, and Lee, LY, additional
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- 2023
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8. The Glory of Young Adult Literature.
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Lee, Ly
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Young adult literature (YAL) is an important and valuable tool for helping students learn and for motivating them to read. YAL also helps students gain insights into themselves and others. YAL (1) is written and marketed primarily for teenagers; (2) has main characters similar in age (12-25) to its readership; (3) has relatively uncomplicated plot lines; and (4) has issues matching the interests, needs, and concerns of teens. Historical fiction, coming-of-age, science fiction, fantasy, mystery/suspense, and non-fiction are the principal genres. Another genre called horror or shock fiction has been criticized by some as inappropriate. The coming-of-age genre deals with problems adolescents face; other genres, such as historical fiction/non-fiction in Crowdog's "Lakota Woman," overlap. YAL, as all other forms of literature, has its limitations--that is why YAL should be used as a supplement to the main texts of the class, where it may help with lessons by offering further insights, fact retention, and enjoyment. (Contains 6 references; lists of coming-of-age and cultural YA books are appended.) (CR)
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- 1997
9. Supplementary Figure Legend from Milatuzumab-Conjugated Liposomes as Targeted Dexamethasone Carriers for Therapeutic Delivery in CD74+ B-cell Malignancies
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Mao, Yicheng, primary, Triantafillou, Georgia, primary, Hertlein, Erin, primary, Towns, William, primary, Stefanovski, Matthew, primary, Mo, Xiaokui, primary, Jarjoura, David, primary, Phelps, Mitch, primary, Marcucci, Guido, primary, Lee, Ly James, primary, Goldenberg, David M., primary, Lee, Robert J., primary, Byrd, John C., primary, and Muthusamy, Natarajan, primary
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- 2023
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10. Supplementary Figure 1 from Milatuzumab-Conjugated Liposomes as Targeted Dexamethasone Carriers for Therapeutic Delivery in CD74+ B-cell Malignancies
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Mao, Yicheng, primary, Triantafillou, Georgia, primary, Hertlein, Erin, primary, Towns, William, primary, Stefanovski, Matthew, primary, Mo, Xiaokui, primary, Jarjoura, David, primary, Phelps, Mitch, primary, Marcucci, Guido, primary, Lee, Ly James, primary, Goldenberg, David M., primary, Lee, Robert J., primary, Byrd, John C., primary, and Muthusamy, Natarajan, primary
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- 2023
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11. Supplementary Table 1, Figures 1 - 5 from Targeted Delivery of microRNA-29b by Transferrin-Conjugated Anionic Lipopolyplex Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia
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Huang, Xiaomeng, primary, Schwind, Sebastian, primary, Yu, Bo, primary, Santhanam, Ramasamy, primary, Wang, Hongyan, primary, Hoellerbauer, Pia, primary, Mims, Alice, primary, Klisovic, Rebecca, primary, Walker, Alison R., primary, Chan, Kenneth K., primary, Blum, William, primary, Perrotti, Danilo, primary, Byrd, John C., primary, Bloomfield, Clara D., primary, Caligiuri, Michael A., primary, Lee, Robert J., primary, Garzon, Ramiro, primary, Muthusamy, Natarajan, primary, Lee, Ly James, primary, and Marcucci, Guido, primary
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- 2023
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12. Study on the Influence of Microinjection Molding Processing Parameters on Replication Quality of Polylactic Acid Microneedle Array Product
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Yu, Wenqian, primary, Gu, Junfeng, additional, Li, Zheng, additional, Ruan, Shilun, additional, Chen, Biaosong, additional, Shen, Changyu, additional, Lee, Ly James, additional, and Wang, Xinyu, additional
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- 2023
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13. List of Contributors
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Cabrera, Eusebio D., primary, Castro, Jose M., additional, Chu, Zengyong, additional, Hu, Tianjiao, additional, Huang, Wenyi, additional, James Lee, Ly, additional, Li, Yihe, additional, Li, Xiaodong, additional, Li, Gongyi, additional, Ma, Jun, additional, and Zhao, Yanan, additional
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- 2018
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14. Carbon Nanopaper
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Zhao, Yanan, primary, Cabrera, Eusebio D., additional, Castro, Jose M., additional, and James Lee, Ly, additional
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- 2018
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15. Large-area graphene coating via superhydrophilic-assisted electro-hydrodynamic spraying deposition
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Wang, Li-Ju, Li, Lei, Yu, Jianfeng, Wu, Yun, He, Hongyan, Ouyang, Xilian, Zhao, Xi, Yen, Ying-Chieh, and Lee, Ly James
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- 2014
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16. Leukemia-initiating HSCs in chronic lymphocytic leukemia reveal clonal leukemogenesis and differential drug sensitivity
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Chiang, Chi-Ling, primary, Hu, Eileen Y., additional, Chang, Lingqian, additional, Labanowska, Jadwiga, additional, Zapolnik, Kevan, additional, Mo, Xiaokui, additional, Shi, Junfeng, additional, Doong, Tzyy-Jye, additional, Lozanski, Arletta, additional, Yan, Pearlly S., additional, Bundschuh, Ralf, additional, Walker, Logan A., additional, Gallego-Perez, Daniel, additional, Lu, Wu, additional, Long, Meixiao, additional, Kim, Sanggu, additional, Heerema, Nyla A., additional, Lozanski, Gerard, additional, Woyach, Jennifer A., additional, Byrd, John C., additional, Lee, Ly James, additional, and Muthusamy, Natarajan, additional
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- 2022
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17. Lactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinoma
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Zhang, Mengzi, Zhou, Xiaoju, Wang, Bo, Yung, Bryant C., Lee, Ly J., Ghoshal, Kalpana, and Lee, Robert J.
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- 2013
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18. PT10 Utility of the ISPOR Presentations Database to Support the Centers for Medicare and Medicaid Services (CMS) Drug Price Negotiation (DPN): An Apixaban and Rivaroxaban Case Study
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Lee, LY, Valliant, SN, Willke, R, Higashi, M, and Pizzi, L
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- 2024
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19. Cell membrane damage and cargo delivery in nano-electroporation.
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Pan, Junjie, Chiang, Chi-ling, Wang, Xinyu, Bertani, Paul, Ma, Yifan, Cheng, Junao, Talesara, Vishank, Lee, Ly James, and Lu, Wu
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- 2023
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20. Lipid nanoparticles for hepatic delivery of small interfering RNA
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Yu, Bo, Hsu, Shu-Hao, Zhou, Chenguang, Wang, Xinmei, Terp, Megan C., Wu, Yun, Teng, Lesheng, Mao, Yicheng, Wang, Feng, Xue, Weiming, Jacob, Samson T., Ghoshal, Kalpana, Lee, Robert J., and Lee, Ly J.
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- 2012
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21. Laryngeal mask airway in out-of-hospital cardiac arrest
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Tang, YN, primary, Lui, CT, additional, Fung, HT, additional, Lee, LY, additional, and Lau, CL, additional
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- 2021
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22. Knowledge and awareness of maternal chronic hepatitis carriers to perinatal antiviral use in prevention of mother-to-child hepatitis B virus transmission
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Low, JM, primary, Ma, T, additional, Lee, GH, additional, and Lee, LY, additional
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- 2021
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23. Thermoplastic polyurethane microcellular fibers via supercritical carbon dioxide based extrusion foaming
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Dai, Chenglong, Zhang, Cailiang, Huang, Wenyi, Chang, Kung-Chin, and Lee, Ly James
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Thermoplastics -- Production processes -- Composition ,Polyurethanes -- Production processes ,Carbon dioxide -- Usage ,Plastics -- Extrusion ,Engineering and manufacturing industries ,Science and technology - Abstract
This study aims to develop, for the first time, thermoplastic polyurethane (TPU) microcellular composite fibers via an extrusion foaming process using supercritical C[O.sub.2] as a blowing agent. Results showed that by employing organically modified montmorillonite clay nanoparticles (CloisiteTR 20A) in the matrix at an optimal concentration of about 1.0 wt%, the nucleation rate of foaming was enhanced, thus resulting in the formation of small bubbles in the extruded fibers. Cell sizes as low as several microns or even submicron and fiber diameters less than 30 pm were obtained in the present study. When processed with 0.5 wt% of a slip agent (Oleamide TR121), the extruded TPU fiber foams exhibited fewer cells near the fiber surface. Mechanical studies showed that the tensile modulus per mass based on the initial slope of the stress-strain curve remained almost the same for both unstretched and stretched fibers with or without foaming. However, the yield stress and the maximum tensile load at an equal mass basis were lower for fibers with foaming. POLYM. ENG. SCI., 53:2360-2369, 2013. © 2013 Society of Plastics Engineers, INTRODUCTION Polymeric foams have been widely used in many applications such as packaging, acoustic dampening, thermal insulation, and tissue engineering (1). In past decades, microcellular foams have drawn a great [...]
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- 2013
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24. Is Cardiopulmonary Bypass Standby Still Required for Laser Lead Extractions?
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Russo Mj, Verghis N, Lee Ly, lemaire a, Ikegami H, Takebe M, and Volk L
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medicine.medical_specialty ,law ,business.industry ,Cardiopulmonary bypass ,medicine ,Intensive care medicine ,Lead (electronics) ,Laser ,business ,law.invention - Abstract
Objective: Over the last two decades there has been an increase in the number of cardiac implantable electronic devices and consequently, there has also been an increased need for lead extractions. Fibrotic attachments develop between the lead and the venous and cardiac structures that may require the use of a laser to mobilize the lead. Cardiothoracic surgeons (CTS) have traditionally provided backup for surgical emergencies for these extractions. This study evaluates the surgical outcomes of patients undergoing transvenous laser lead extractions (TLE) and determines if CTS are still needed for backup.Methods: A retrospective review of consecutive patients undergoing laser lead extractions at a single academic center. Lead extractions using only laser sheaths were analyzed. The clinical characteristics, complications, and mortality of the patients were evaluated.Results: One hundred and twenty-one patients underwent TLEs from January 1st, 2014 to December 31st, 2018. The majority were male (N=80, 66.1%), and the average age was 66.48 ± 14 years. The indication for removal was either laser lead malfunction or infection. A total of 30 patients (24.8%) had complications postoperatively including wound hematomas, superficial infections, and arrhythmias. The average length of stay was 9±12 for all the patients in the study. 2 patients (1.6%) had injuries that required emergency surgical repair with injuries to the posterior superior vena cava and right ventricle. Both patients survived the initial injury with one patient was discharged home on day 4 and the other succumbing to his injuries on postoperative day 20.Conclusion: Although the incidence of surgical emergencies is rare the morbidity and mortality for TLE require that surgical backup be available.
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- 2021
25. AlGaN/GaN heterostructure field transistor for label-free detection of DNA hybridization
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Wen, XueJin, Wang, ShengNian, Wang, YuJi, Lee, Ly James, and Lu, Wu
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- 2013
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26. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study
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Lee, LY, Cazier, J-B, Angelis, V, Arnold, R, Bisht, V, Campton, NA, Chackathayil, J, Cheng, VW, Curley, HM, Fittall, MW, Freeman-Mills, L, Gennatas, S, Goel, A, Hartley, S, Hughes, DJ, Kerr, D, Lee, AJ, Lee, RJ, McGrath, SE, Middleton, CP, Murugaesu, N, Newsom-Davis, T, Okines, AF, Olsson-Brown, AC, Palles, C, Pan, Y, Pettengell, R, Powles, T, Protheroe, EA, Purshouse, K, Sharma-Oates, A, Sivakumar, S, Smith, AJ, Starkey, T, Turnbull, CD, Várnai, C, Yousaf, N, Team, UK Coronavirus Monitoring Project, Kerr, R, and Middleton, G
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Male ,medicine.medical_specialty ,Coronavirus Infections/complications ,Comorbidity ,Disease ,030204 cardiovascular system & hematology ,Betacoronavirus ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Risk Factors ,Cause of Death ,Internal medicine ,Clinical endpoint ,Humans ,Medicine ,Neoplasms/complications ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Pandemics ,Aged ,Cause of death ,Manchester Cancer Research Centre ,business.industry ,ResearchInstitutes_Networks_Beacons/mcrc ,Age Factors ,Antineoplastic Agents/therapeutic use ,Cancer ,Odds ratio ,General Medicine ,Middle Aged ,medicine.disease ,Female ,Observational study ,Pneumonia, Viral/complications ,business - Abstract
Background Individuals with cancer, particularly those who are receiving systemic anticancer treatments, have been postulated to be at increased risk of mortality from COVID-19. This conjecture has considerable effect on the treatment of patients with cancer and data from large, multicentre studies to support this assumption are scarce because of the contingencies of the pandemic. We aimed to describe the clinical and demographic characteristics and COVID-19 outcomes in patients with cancer. Methods In this prospective observational study, all patients with active cancer and presenting to our network of cancer centres were eligible for enrolment into the UK Coronavirus Cancer Monitoring Project (UKCCMP). The UKCCMP is the first COVID-19 clinical registry that enables near real-time reports to frontline doctors about the effects of COVID-19 on patients with cancer. Eligible patients tested positive for severe acute respiratory syndrome coronavirus 2 on RT-PCR assay from a nose or throat swab. We excluded patients with a radiological or clinical diagnosis of COVID-19, without a positive RT-PCR test. The primary endpoint was all-cause mortality, or discharge from hospital, as assessed by the reporting sites during the patient hospital admission. Findings From March 18, to April 26, 2020, we analysed 800 patients with a diagnosis of cancer and symptomatic COVID-19. 412 (52%) patients had a mild COVID-19 disease course. 226 (28%) patients died and risk of death was significantly associated with advancing patient age (odds ratio 9·42 [95% CI 6·56–10·02]; p Interpretation Mortality from COVID-19 in cancer patients appears to be principally driven by age, gender, and comorbidities. We are not able to identify evidence that cancer patients on cytotoxic chemotherapy or other anticancer treatment are at an increased risk of mortality from COVID-19 disease compared with those not on active treatment. Funding University of Birmingham, University of Oxford.
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- 2020
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27. Case control study of risk factors and ophthalmological outcomes of very low birth weight infants with Type 1 retinopathy of prematurity
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Ng, TR, primary, Wong, IB, additional, Ngo, CS, additional, Niduvaje, K, additional, Ngiam, XY, additional, Sensaki, S, additional, and Lee, LY, additional
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- 2020
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28. Cost-effectiveness analysis of antiviral treatment for pregnant women with high viral load to prevent hepatitis B virus vertical transmission
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Ma, T, primary, Lee, LY, additional, Aw, MM, additional, and Lee, GH, additional
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- 2020
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29. Effect of growth temperature and V/III-ratio on the surface morphology of MOVPE-grown cubic zincblende GaN
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Lee, LY, Frentrup, M, Kappers, MJ, Oliver, RA, Humphreys, CJ, Wallis, DJ, Lee, LY [0000-0002-4065-2084], Oliver, RA [0000-0003-0029-3993], Humphreys, CJ [0000-0001-5053-3380], and Apollo - University of Cambridge Repository
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40 Engineering - Abstract
The influence of growth temperature and V/III-ratio on the surface morphology of (001) cubic zincblende GaN epilayers during metal organic vapour phase epitaxy growth has been investigated using atomic force microscopy and transmission electron microscopy. The zincblende phase purity as determined by X-ray diffraction was found to be above 98% for most GaN epilayers studied. As the growth temperature was increased from 850 °C to 910 °C and as the V/III-ratio was separately increased from 38 to 300, surface features were found to be elongated in the [1-10] direction, and the ratio of the length to width of such surface features was found to increase. Faceting was observed at V/III-ratios below 38 and above 300, which in the latter case was accompanied by a reduction of the zincblende phase purity. An explanation for these morphological trends is proposed based on effects such as the reduced symmetry of the top monolayer of the (001)-oriented zincblende GaN lattice, diffusion of Ga and N adatoms on such a surface, and the relative energies of the crystal facets.
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- 2018
30. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
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Perkovic, V., Jardine, M. J., Neal, B., Bompoint, S., Heerspink, H. J. L., Charytan, D. M., Edwards, R., Agarwal, R., Bakris, G., Bull, S., Cannon, C. P., Capuano, G., Chu, P. -L., De Zeeuw, D., Greene, T., Levin, A., Pollock, C., Wheeler, D. C., Yavin, Y., Zhang, H., Zinman, B., Meininger, G., Brenner, B. M., Mahaffey, K. W., Perkovic, V, Mahaffey, Kw, Agarwal, R, Bakris, G, Brenner, Bm, Cannon, Cp, Charytan, Dm, de Zeeuw, D, Greene, T, Jardine, Mj, Heerspink, Hjl, Levin, A, Meininger, G, Neal, B, Pollock, C, Wheeler, Dc, Zhang, H, Zinman, B, Mcguire, Dk, Holman, R, Home, P, Scharfstein, D, Parfrey, P, Shahinfar, S, August, P, Chang, T, Sinha, Ad, Januzzi, J, Kolansky, D, Amerena, J, Hillis, G, Gorelick, P, Kissela, B, Kasner, S, Lindley, R, Fulcher, G, Ounadjela, S, Hufert, K, von Ingersleben, G, Gaglia, J, Harris, R, Hudson, M, Turchin, A, Cheifetz, A, Sheth, S, Feuerstein, J, Cohen, S, Jardine, M, Li, N, Kolesnyk, I, Aizenberg, D, Pecoits-Filho, R, Cherney, D 3rd, Obrador, G, Chertow, G, Hawley, C, Ji, L, Wada, T, Jha, V, Lim, Sk, Lim-Abrahan, Ma, Santos, F, Chae, Dw, Hwang, Sj, Vazelov, E, Rychlík, I, Hadjadj, S, Krane, V, Rosivall, L, De Nicola, L, Dreval, A, Nowicki, M, Schiller, A, Distiller, L, Górriz, Jl, Kolesnyk, M, Morren, F, Goykhman, S, David, C, Yost, L, Wang, H, Hettiarachchi, M, Thimmaiah, R, Koppolu, D, George, S, Schmidt, M, Ignjatovic, J, Chapin, L, Travis, K, Destree, M, Sood, V, Coffee, L, De Brouwer, K, Zaviriukha, V, Starzec, A, Koizumi, M, Lin, G, Chen, E, Lin, P, Leia, C, Mascaro, D, Amigo, A, Limos, A, Abrahamsen, I, Jaffer, S, Ahuad Guerrero RA, Albisu, Jp, Alvarisqueta, A, Bartolacci, I, Berli, Ma, Bordonava, A, Calella, P, Cantero, Mc, Cartasegna, Lr, Cercos, E, Coloma, Gc, Colombo, H, Commendatore, V, Cuadrado, J, Cuneo, Ca, Cusumano, Am, Douthat, Wg, Dran, Rd, Farias, E, Fernandez, Mf, Finkelstein, H, Fragale, G, Fretes, Jo, Garcia, Nh, Gastaldi, A, Gelersztein, E, Glenny, Ja, Gonzalez, Jp, Gonzalez Colaso PDC, Goycoa, C, Greloni, Gc, Guinsburg, A, Hermida, S, Juncos, Li, Klyver, Mi, Kraft, F, Krynski, F, Lanchiotti, Pv, Leon de la Fuente RA, Marchetta, N, Mele, P, Nicolai, S, Novoa, Pa, Orio, Si, Otreras, F, Oviedo, A, Raffaele, P, Resk, Jh, Rista, L, Rodriguez Papini, N, Sala, J, Santos, Jc, Schiavi, Lb, Sessa, H, Smith Casabella, T, Ulla, Mr, 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M, Harcsa, E, Keltai, K, Keresztesi, S, Kiss, K, Konyves, L, Major, L, Mileder, M, Molnar, M, Mucsi, J, Oroszlan, T, Ory, I, Paragh, G, Peterfai, E, Petro, G, Revesz, K, Takacs, R, Vangel, S, Vasas, S, Zsom, M, Abraham, O, Bhushan, R, Deepak, D, Edwin, Fm, Gopalakrishnan, N, Gracious, N, Hansraj, A, Jain, D, Keshavamurthy, Cb, Khullar, D, Manisha, S, Peringat, J, Prasad, N, Satyanarayana, Rk, Sreedhar, R, Sreelatha, M, Sudhakar, B, Vyasam, Rc, Bonadonna, R, Castellino, P, Ceriello, A, Chiovato, L, De Cosmo, S, Derosa, G, Di Carlo, A, Di Cianni, G, Frascà, G, Fuiano, G, Gambaro, G, Garibotto, G, Giorda, C, Malberti, F, Mandreoli, M, Mannucci, E, Orsi, E, Piatti, P, Santoro, D, Sasso, Fc, Serviddio, G, Stella, A, Trevisan, R, Veronelli, Am, Zanoli, L, Akiyama, H, Aoki, H, Asano, A, Iitsuka, T et al, Groningen Kidney Center (GKC), and Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)
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Aged ,Canagliflozin ,Cardiovascular Diseases ,Creatinine ,Diabetes Mellitus, Type 2 ,Diabetic Nephropathies ,Double-Blind Method ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Humans ,Kidney Failure, Chronic ,Male ,Middle Aged ,Sodium-Glucose Transporter 2 Inhibitors ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Diabetic nephropathy ,Kidney Failure ,chemistry.chemical_compound ,0302 clinical medicine ,030212 general & internal medicine ,03.02. Klinikai orvostan ,Dapagliflozin ,Chronic ,11 Medical and Health Sciences ,EMPAGLIFLOZIN ,General Medicine ,Life Sciences & Biomedicine ,Type 2 ,medicine.drug ,medicine.medical_specialty ,Nephropathy ,03 medical and health sciences ,Medicine, General & Internal ,Internal medicine ,Diabetes mellitus ,General & Internal Medicine ,CREDENCE Trial Investigators ,medicine ,Diabetes Mellitus ,Science & Technology ,business.industry ,urogenital system ,diabetic nephropathy ,Type 2 Diabetes Mellitus ,KIDNEY-DISEASE ,medicine.disease ,chemistry ,business ,Kidney disease - Abstract
BACKGROUND: Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS: In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin-angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of
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- 2019
31. Chapter 4 - Carbon Nanopaper: A Platform to High-Performance Multifunctional Composites
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Zhao, Yanan, Cabrera, Eusebio D., Castro, Jose M., and James Lee, Ly
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- 2018
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32. The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics
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Abdallah J, Abdul Ghani R, Abdul Kadir K, Abdullah R, Abejuela Z, Abraham O, Abramowitz M, Abusnana S, Accini Mendoza JL, Acosta I, Agafyina A, Aggarwal N, Ahmed F, Ahuad Guerrero RA, Aiello J, Ainsworth P, Aizenberg D, Akiyama H, Akright L, Akyea-Djamson A, Alamartine E, Alappan R, Ali N, Ali Z, Alicic R, Al-Karadsheh A, Alpizar Salazar M, Alvarez Garcia P, Alvarisqueta A, Amodeo C, Andreeva V, Andreotti Turatti LA, Angelescu LM, Angelova A, Anghel V, Antic S, Aoki H, Aquitania G, Arauz-Pacheco C, Arce-Nunez E, Arcos Palma EG, Arfeen S, Arif A, Aronson R, Arutchelvam V, Asano A, Atray N, Avram RI, Awad A, Baas Cruz J, Babikova J, Badat A, Bajaj H, Baker J, Bakris G, Barbarash O, Barna O, Barnard M, Barranco E, Barrera C, Bartaskova D, Bartolacci I, Barysheva O, Behara V, Bellary S, Belo D, Bentley-Lewis R, Benusova O, Berenguer R, Berli MA, Bernardo M, Biscoveanu M, Bordonava AP, Borot S, Botsyurko V, Bowman-Stroud C, Brandon D, Bregman R, Brusco O, Buganova I, Burgos Soto M, Busch R, Busegeanu MM, Calella P, Camelo Sanches FC, Canaan Y, Canani LH, Cantero MC, Cariou B, Cartasegna LR, Castellino P, Cereto Castro F, Certow G, Chacra AR, Chae DW, Chang CT, Chang T, Che Yusof MD, Chen N, Chen Q, Cherney D, Cheung NW, Chevaile Ramos J, Chew Wong A, Chiovato L, Chizhov D, Cho YM, Christiano C, Christofides E, Chuang LM, Chuateco C, Cif A, Cigarran Guldris S, Cohen K, Cohen R, Coloma GC, Comia RS, Commendatore V, Conway J, Cook C, Cosma D, Cournoyer S, Coyne D, Crisan C, Csecsei G, Csiky B, Cuadrado J, Cuneo CA, Cunha Borges JL, Cunha Vêncio SA, Cusumano AM, da Silva Franco RJ, Daboul N, Danos P, DaRoza G, Davies E, Davies M, Davies S, Dawson A, De Cosmo S, De Nicola L, De Serres S, de Souza Portes E, Deak L, Deck K, Deepak D, Derosa G, Desouza C, Dev D, Dhillon M, DI CARLO, Alfonso, Di Cianni G, Diaz Escalante T, Dimitrov S, Distiller L, Djordjevic M, Dobronravov V, Dohnalova L, Dominguez Lopez M, Douthat WG, Dran RD, Drasnar T, Dreval A, Droste C, Dua S, Dube F, Dudar I, Dudas M, Dussol B, Dzupina A, Eder F, Egido de Los Rios J, El Kossi M, El-Shahawy M, English P, Enriquez Sosa FE, Ervin J, Esquenazi A, Evans J, Faghih M, Farias E, Faulmann G, Fauvel JP, Ferariu IE, Fernandez MF, Fernandez Fresnedo G, Fernandez Montenegro MA, Finkelstein H, Flores Lozano F, Flota Cervera L, Fraige Filho F, Fraser D, Frenk Baron P, Fretes JO, Frias J, Fuiano G, Fulop P, Fushtey I, Galan Serrano A, Galphin C, Gan S, Gan CL, Garcia NH, Garcia I, Garcia Ballesteros C, Garcia Ortiz LH, Garrido N, Gastaldi A, Gelersztein E, Geloneze Neto B, Genadieva V, Genova-Hristova G, Genovese S, Ghazi A, Giorda C, Glenny JA, Glinkina I, Godlevska O, Godoy Jorquera JG, Goldenberg R, Golovchenko O, Gomes Bastos M, Gomez O, Gomez Rangel JD, Gonzalez E, Gonzalez Dorado A, Gonzalez Martinez FJ, Gonzalez Orellana RA, Gopalakrishnan N, Gorriz JL, Gorson D, Govender V, Gracious N, Greco B, Gregar R, Greloni GC, Grineva E, Guinsburg A, Gulati R, Gunstone A, Gupta A, Gupta M, Gyrina O, Hadjadj S, Halciakova K, Hall T, Haller H, Halmagyi I, Hammoud J, Hancu N, Hanif W, Hansraj A, Hawley C, Henein S, Hermida S, Hernandez Triana E, Herrera Jimenez LE, Hershon K, Higuera Cobos JD, Hiser D, Hocking S, Hon G, Hristozov K, Hsieh CH, Hura C, Hwang SJ, Ilavska A, Irizar Santana SS, Ismail M, Jackson A, Jain D, Jamal A, Januszewicz A, Jeong IK, Jha V, Jimenez Flores F, Jodar Gimeno JE, Johnson A, Joseph F, Joshi M, Juncos LI, Jurgens J, Kajiyama S, Kaminska A, Kashine S, Kaupke C, Kawada T, Keiko Kohara S, Keitel E, Keltai K, Kendereski A, Keresztesi S, Kern E, Kerr Saraiva JF, Keshavamurthy CB, Khandwala H, Khanna R, Khitan Z, Khullar D, Kim SG, Kim YH, Kim S, Kiss K, Klein A, Klyver MI, Kodera T, Kolesnyk M, Kolmakova E, Komisarenko I, Kong Y, Kong WY, Kono H, Konyves L, Kopyt N, Korzh O, Kovar R, Kovesdy C, Koyama K, Kozloviene D, Kraft F, Krane V, Kravchun N, Krishna G, Krishnan S, Kropp JJ, Kumar A, Kumar J, Kumeda Y, Kumwenda M, Kurtz Lisboa HR, Kvitkova L, Kwon HS, Kwon MJ, Lalic K, Lalic N, Lanchiotti PV, Lastuvka J, Laviada Molina H, Lawrence M, Le Meur Y, Lee LY, Lee BW, Lee J, Lee MK, Legun O, Leiter L, Lentz J, Leon de la Fuente RA, Levin A, Lewis D, Li D, Li W, Li X, Lim SK, Lin H, Lin CC, Liss K, Liu J, Loh CL, Lombard L, Lopez Mendoza M, Lopez Tarabay C, Lorenzoni d'avila DO, Loss de Carvalho Contieri F, Lu W, Lu YC, Luna Ceballos R, M. 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Nicholls, K, Nicol, P, Nieto Iglesias, J, Niiya, T, Nik Ahmad, Nnf, Nisnisan, J, Nonchev, B, Noronha, Il, Nortje, H, Nossuli, Ak, Nowicki, M, Obialo, C, Obrador Vera, G, Ochodnicka, Z, Oh, Kh, Oishi, H, Olelewe, S, Oliver, M, Oosthuizen, H, Orio, Si, Orlowska-Kowalik, G, Oroszlan, T, Orozco Castellanos, R, Orsi, E, Ory, I, O'Shaughnessy, A, Ota, S, Otreras, F, Oviedo, A, Packham, D, Padron, J, Panarotto, D, Pankhaniya, R, Pantoja Perez, J, Paragh, G, Park, Cy, Park, Sh, Pashkovska, N, Patel, D, Patel, G, Pavon, H, Pei, D, Pella, D, Penfornis, A, Peralta Calcaneo, J, Pereira, Ma, Pererva, L, Perez Vera, M, Peringat, J, Pertseva, T, Pesickova, S, Peterfai, E, Peterka, K, Petrica, L, Petro, G, Pettis, K, Pharr, W, Philip, S, Phillips, A, Piatti, P, Pichette, V, Pontiroli, A, Popa, Ar, Popenda, G, Popovic-Radinovic, V, Portoles Perez, Jm, Prasad, N, Proietto, J, Prozesky, H, Pumprla, J, Purighalla, R, Quesada Simon, Ma, Quesada-Suarez, L, Rabasa-Lhoret, R, Ramirez Roca, La, Ramtoola, S, Ranetti, Ae, Rangelov, R, Ranjan, R, Raskina, T, Rastogi, S, Ratnasingam, V, Reddy, J, Ren, Y, Resk, Jh, Rewerska, B, Reyes Rosano, Ma, Rich, L, Rista, L, Roberts, A, Robinson, M, Rodelo, J, Rodriguez, H, Rodriguez Papini, N, Roger, S, Rosas, S, Rosas Guzman, J, Rosivall, L, Roussel, R, Rucker Joerg, Ie, Rychlik, I, Saavedra Gajardo, V, Saavedra Sanchez, Sb, Sala, J, Samoylov, O, Samoylova, Y, Sanchez Arenales, Ja, Sanchez Mijangos, Jh, Sanchez Polo, Jv, Sankaram, R, Santoro, D, Santos, Jc, Santos, F, Sarin, R, Saudek, F, Saumell, F, Saxena, M, Sazonova, O, Schiavi, Lb, Schiller, A, Schuch, T, Scott, R, Scott, D, Seeber, M, Seiji Yamada, S, Sekkarie, M, Sensenbrenner, J, Serafinceanu, C, Serrano Sanson, P, Sessa, H, Shakeel, M, Shamkhalova, M, Shanik, M, Shaw, S, Sheu, Wh, Shinkov, A, Shutemova, E, Silva Pecoits Filho, Rf, Simo Canonge, R, Simoes de Almeida, R, Simon, G, Singh, B, Slompo Ramos, C, Smatanova, I, Smirnov, I, Smith, S, Smith Casabella, T, Soares Felicio, J, Soler Romeo, Mj, Solomon, R, Song, W, Soto Gonzalez, A, Sowinski, D, Sprague, A, Sree Bhushan, R, Sreedhar, R, Sreelatha, M, Steele, A, Spedding, Stephen John, Strzelecka, A, Suchinda, P, Sudhakar, B, Sun, J, Sun, L, Surampudi, P, Sussman, S, Svyshchenko, Y, Symonds, R, Szlachcic, Y, Takacs, R, Takai, M, Tamayo Y., Orozco J, Tan, G, Tellez Chavez, E, Temelkova, M, Terns Riera, M, Terront Lozano, Ma, Tesar, V, Thompson, M, Tibes Hachmann, Jc, Tinahones Madueno, Fj, Tolentino, M, Tomashkevych, H, Tomonaga, O, Topchii, I, Torshizi, A, Trespalacios, F, Trevisan, R, Trueba, P, Tryshchuk, N, Tseluyko, V, Tsujimoto, M, Tu, P, Turcios Juarez, E, Turner, W, Twahirwa, M, Ulla, Mr, Updegrove, J, Urbanaviciene, E, Valderrama Cometa, L, Valdes Cepeda, A, Valenzuela, A, Valis, M, Vallejos, A, Vangel, S, Vannorsdall, M, Vargas Alonso, Rd, Varghese, F, Vasas, S, Vazelov, E, Vejar, M, Velasquez-Mieyer, P, Velichkova, E, Velo, M, Venegas Carrillo, L, Vengadasalam, P, Ventrapragada, S, Villagordoa Mesa, J, Villarino, Aa, Villegas, I, Visco, Ve, Vizir, V, Vlasenko, M, Vyasam, Rc, Wada, T, Wadud, K, Wahba, M, Wakasugi, M, Wakeling, J, Wakida, Y, Walker, JOHN RICHARD, Wang, G, Warren, M, Wassermann, A, Watanabe, T, Watson, E, Watts, R, Weiner, P, Weiner, D, Welsh, J, Wheeler, D, Williams, M, Winocour, P, Woo, V, Yamada, M, Yanagida, K, Yanase, T, Yang, J, Yao, C, Yap, Ye, Ygpuara, Mdl, Yin, A, Yoiti Hayashida, C, Yoon, Kh, Young, S, Yu, X, Yumita, W, Yupanqui, H, Zaidman, Cj, Zamarripa Escobedo, R, Zanata Petry, Tb, Zanella, Mt, Zaoui, P, Zavaroni, I, Zemek, S, Zhang, H, Zhao, M, Zheng, H, Zlova, T, Zsom, M, and Zykova, T.
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medicine.medical_specialty ,ALBUMINURIA ,Urology ,Renal function ,030209 endocrinology & metabolism ,PROGRESSION ,Type 2 diabetes ,Diabetic nephropathy ,030204 cardiovascular system & hematology ,GLOMERULAR-FILTRATION-RATE ,CARDIOVASCULAR OUTCOMES ,Nephropathy ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Chronic kidney disease ,medicine ,03.02. Klinikai orvostan ,Renal outcome ,Canagliflozin ,Science & Technology ,ATRIAL-NATRIURETIC-PEPTIDE ,IRBESARTAN ,GFR DECLINE ,business.industry ,1103 Clinical Sciences ,KIDNEY-DISEASE ,Urology & Nephrology ,medicine.disease ,Renal outcomes ,Nephrology ,COLLABORATIVE METAANALYSIS ,Albuminuria ,Original Report: Patient-Oriented, Translational Research ,LOSARTAN ,medicine.symptom ,business ,Life Sciences & Biomedicine ,CREDENCE study investigators ,medicine.drug ,Kidney disease - Abstract
Background: People with diabetes and kidney disease have a high risk of cardiovascular events and progression of kidney disease. Sodium glucose co-transporter 2 inhibitors lower plasma glucose by reducing the uptake of filtered glucose in the kidney tubule, leading to increased urinary glucose excretion. They have been repeatedly shown to induce modest natriuresis and reduce HbA1c, blood pressure, weight, and albuminuria in patients with type 2 diabetes. However, the effects of these agents on kidney and cardiovascular events have not been extensively studied in patients with type 2 diabetes and established kidney disease. Methods: The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial aims to compare the efficacy and safety of canagliflozin versus placebo at preventing clinically important kidney and cardiovascular outcomes in patients with diabetes and established kidney disease. CREDENCE is a randomized, double-blind, event-driven, placebo-controlled trial set in in 34 countries with a projected duration of ∼5.5 years and enrolling 4,401 adults with type 2 diabetes, estimated glomerular filtration rate ≥30 to 2, and albuminuria (urinary albumin:creatinine ratio >300 to ≤5,000 mg/g). The study has 90% power to detect a 20% reduction in the risk of the primary outcome (α = 0.05), the composite of end-stage kidney disease, doubling of serum creatinine, and renal or cardiovascular death. Conclusion: CREDENCE will provide definitive evidence about the effects of canagliflozin on renal (and cardiovascular) outcomes in patients with type 2 diabetes and established kidney disease. Trial Registration: EudraCT number: 2013-004494-28; ClinicalTrials.gov identifier: NCT02065791.
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- 2017
33. Stimuli-responsive Carriers for Controlled Intracellular Drug Release
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Sheng, Yan, primary, Hu, Jiaming, additional, Shi, Junfeng, additional, and Lee, Ly James, additional
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- 2019
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34. SiOC‐Accelerated Graphene Grown on SiO 2 /Si with Tunable Electronic Properties
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Garman, Paul D., primary, Yang, Hao, additional, Yen, Ying‐Chieh, additional, Yu, Jianfeng, additional, Kwak, Kwang Joo, additional, Malkoc, Veysi, additional, Talesara, Vishank V., additional, Lee, Ly J., additional, and Lu, Wu, additional
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- 2019
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35. Subcritical CO2 Assisted Polymer Surface Engineering at Low Temperatures
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Yang, Yong and Lee, Ly James
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- 2004
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36. PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation
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J Liu, Saadat S, Han Y, Lee Ly, Pier Paolo Pandolfi, Guo-Hua Fong, Li S, Qi Y, and Tian X
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Mammalian embryology ,Apoptosis ,Embryoid body ,Epithelium ,Mitochondrial Proteins ,Mice ,Downregulation and upregulation ,Animals ,PTEN ,Tensin ,Molecular Biology ,Protein kinase B ,Mice, Knockout ,Regulation of gene expression ,Original Paper ,biology ,PTEN Phosphohydrolase ,Gene Expression Regulation, Developmental ,Membrane Proteins ,Cell Biology ,Embryo, Mammalian ,Up-Regulation ,Cell biology ,Cancer research ,biology.protein ,Proto-Oncogene Proteins c-akt ,Transcription Factors - Abstract
The tumor suppressor phosphatase and tensin homolog (PTEN) dephosphorylates PIP3 and antagonizes the prosurvival PI3K-Akt pathway. Targeted deletion of PTEN in mice led to early embryonic lethality. To elucidate its role in embryonic epithelial morphogenesis and the underlying mechanisms, we used embryonic stem cell-derived embryoid body (EB), an epithelial cyst structurally similar to the periimplantation embryo. PTEN is upregulated during EB morphogenesis in parallel with apoptosis of core cells, which mediates EB cavitation. Genetic ablation of PTEN causes Akt overactivation, apoptosis resistance and cavitation blockade. However, rescue experiments using mutant PTEN and pharmacological inhibition of Akt suggest that the phosphatase activity of PTEN and Akt are not involved in apoptosis-mediated cavitation. Instead, hypoxia-induced upregulation of Bnip3, a proapoptotic BH3-only protein, mediates PTEN-dependent apoptosis and cavitation. PTEN inactivation inhibits hypoxia- and reactive oxygen species-induced Bnip3 elevation. Overexpression of Bnip3 in PTEN-null EBs rescues apoptosis of the core cells. Mechanistically, suppression of Bnip3 following PTEN loss is likely due to reduction of hypoxia-inducible factor-2α (HIF-2α) because forced expression of an oxygen-stable HIF-2α mutant rescues Bnip3 expression and apoptosis. Lastly, we show that HIF-2α is upregulated by PTEN at both transcriptional and posttranscriptional levels. Ablation of prolyl hydroxylase domain-containing protein 2 (PHD2) in normal EBs or inhibition of PHD activities in PTEN-null EBs stabilizes HIF-2α and induces Bnip3 and caspase-3 activation. Altogether, these results suggest that PTEN is required for apoptosis-mediated cavitation during epithelial morphogenesis by regulating the expression of HIF-2α and Bnip3.
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- 2014
37. Mycobacterium tuberculosis Infection Manipulates the Glycosylation Machinery and the N-Glycoproteome of Human Macrophages and Their Microparticles
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Hare, NJ, Lee, LY, Loke, I, Britton, WJ, Saunders, BM, and Thaysen-Andersen, M
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Biochemistry & Molecular Biology ,Glycosylation ,Glycoside Hydrolases ,Proteome ,Macrophages ,Golgi Apparatus ,Glycosyltransferases ,Mycobacterium tuberculosis ,Endoplasmic Reticulum ,Cell Line ,Gene Expression Regulation ,Carbohydrate Sequence ,Cell-Derived Microparticles ,Lectins ,Host-Pathogen Interactions ,Sialic Acids ,Humans ,Lysosomes ,Mannose ,Glycoproteins ,Signal Transduction - Abstract
© 2016 American Chemical Society. Tuberculosis (TB) remains a prevalent and lethal infectious disease. The glycobiology associated with Mycobacterium tuberculosis infection of frontline alveolar macrophages is still unresolved. Herein, we investigated the regulation of protein N-glycosylation in human macrophages and their secreted microparticles (MPs) used for intercellular communication upon M. tb infection. LC-MS/MS-based proteomics and glycomics were performed to monitor the regulation of glycosylation enzymes and receptors and the N-glycome in in vitro-differentiated macrophages and in isolated MPs upon M. tb infection. Infection promoted a dramatic regulation of the macrophage proteome. Most notably, significant infection-dependent down-regulation (4-26 fold) of 11 lysosomal exoglycosidases, e.g., β-galactosidase, β-hexosaminidases and α-/β-mannosidases, was observed. Relative weak infection-driven transcriptional regulation of these exoglycosidases and a stronger augmentation of the extracellular hexosaminidase activity demonstrated that the lysosome-centric changes may originate predominantly from infection-induced secretion of the lysosomal content. The macrophages showed heterogeneous N-glycan profiles and displayed significant up-regulation of complex-type glycosylation and concomitant down-regulation of paucimannosylation upon infection. Complementary intact N-glycopeptide analysis supported a subcellular-specific manipulation of the glycosylation machinery and altered glycosylation patterns of lysosomal N-glycoproteins within infected macrophages. Interestingly, the corresponding macrophage-derived MPs displayed unique N-glycome and proteome signatures supporting a preferential packaging from plasma membranes. The MPs were devoid of infection-dependent N-glycosylation signatures, but interestingly displayed increased levels of the glyco-initiating oligosaccharyltransferase complex and associated α-glucosidases that correlated with increased formation, N-glycan precursor levels and N-glycan density of infected MPs. In conclusion, this system-wide study provides new insight into the host- and pathogen-driven N-glycoproteome manipulation of macrophages in TB.
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- 2017
38. Identification of H5N1-specific T-cell responses in a high-risk cohort in vietnam indicates the existence of potential asymptomatic infections
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Peter Horby, Yanchun Peng, Lili Wang, N T Thu Yen, L T Quynh Mai, Sarah Rowland-Jones, Annette Fox, Nguyen Tran Hien, Cameron P. Simmons, Lee Ly-H., Lien Vtk., Pham Quang Thai, Tao Dong, Hang Nlk., Timothy J. Powell, B A Askonas, Jj J. Farrar, Andrew J. McMichael, and Tran Nhu Duong
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Enzyme-Linked Immunospot Assay ,animal diseases ,T-Lymphocytes ,Hemagglutinin (influenza) ,Hemagglutinin Glycoproteins, Influenza Virus ,medicine.disease_cause ,Antibodies, Viral ,Virus ,Cohort Studies ,Major Articles and Brief Reports ,Seroepidemiologic Studies ,Influenza, Human ,medicine ,Immunology and Allergy ,Seroprevalence ,Humans ,Asymptomatic Infections ,Hemagglutination assay ,biology ,Influenza A Virus, H5N1 Subtype ,virus diseases ,Virology ,Influenza A virus subtype H5N1 ,Vaccination ,Infectious Diseases ,Vietnam ,Immunology ,biology.protein ,Antibody ,Neuraminidase - Abstract
(See the editorial commentary by Epstein, on pages 4–6.) Influenza H5N1 remains endemic in domestic poultry in large parts of Asia, and although the total number of human infections is relatively small, sporadic human cases with a high risk of death are still being reported [1, 2]. Since 2003, >500 human cases of highly pathogenic influenza A H5N1 have been reported, with 119 cases occurring in Vietnam [3]. At present, H5N1 influenza cannot be transmitted readily between humans, but the possibility remains of a recombination between H5N1 and other influenza viruses, resulting in a virulent and easily transmissible virus [4]. The reported frequency and severity of H5N1 infection in humans is almost certainly biased by the underdetection of mild or asymptomatic cases: leading to an underestimate of the number of cases and an overestimate of the case fatality rate. The extent of this bias is indicated by seroprevalence surveys that have reported anti-H5 antibody prevalence in exposed groups of between 0% and 12% [5–9]. The presence of virus-neutralizing antibody is important for protection against influenza, and antibodies that recognize specific hemagglutinin (HA) subtypes can give an indication of recent infection history [10, 11]. However, measurement of H5N1-specific neutralizing antibodies has been problematic because the traditional hemagglutination inhibition (HAI) assay has low sensitivity for the detection of H5N1 antibodies [12]. Alternative assays that have been used for the detection of H5N1 infection include horse erythrocyte HAI, microneutralization, and pseudoparticle assays [13]. These assays are all subject to false-positive reactions due to the presence of cross-subtype neutralizing antibodies [14]. Measuring interferon (IFN) γ secretion by peripheral blood mononuclear cells (PBMCs) after stimulation with pools of HA peptides from different influenza strains demonstrates the specificity and reactivity of T cells generated by strain-specific vaccination [15–17] or memory cells generated after natural infection [18–21]. In this study, we set out to investigate the rate of infection with H5N1 virus in a community in rural Vietnam that had previously experienced H5N1 cases in both poultry and humans by measuring the prevalence of specific T-cell responses against the HA and neuraminidase (NA) of H5N1 influenza virus. We also compared T-cell responses against the proteome of seasonal H3N2 and the HA and N1 of H5N1 and H1N1 influenza in the community cohort with those in a group of persons who had recovered from H5N1 infection and in healthy controls with no exposure to H5N1.
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- 2016
39. Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals
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Yanchun Peng, Jeremy Farrar, Tao Dong, de Jong, Sarah Rowland-Jones, Lee Ly-H., Geoffrey L. Smith, Cameron P. Simmons, B A Askonas, Andrew J. McMichael, Chau Nvv., Townsend Arm., Ha Dla., R Schumacher, and Medical Microbiology and Infection Prevention
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CD4-Positive T-Lymphocytes ,Proteome ,viruses ,T-Lymphocytes ,Epitopes, T-Lymphocyte ,CD8-Positive T-Lymphocytes ,medicine.disease_cause ,Epitope ,Mice ,Clinical investigation ,Influenza A virus ,Medicine ,virus diseases ,General Medicine ,Middle Aged ,medicine.anatomical_structure ,Vietnam ,Health ,Influenza Vaccines ,Healthy individuals ,Seasons ,Research Article ,Adult ,Human influenza ,Vaccinia virus ,Biology ,Cross Reactions ,H5N1 genetic structure ,Antigenic drift ,Viral Matrix Proteins ,Influenza, Human ,Animals ,Humans ,Heterosubtypic immunity ,Influenza A Virus, H5N1 Subtype ,business.industry ,Influenza A Virus, H3N2 Subtype ,Virology ,United Kingdom ,Influenza A virus subtype H5N1 ,Clarification ,Nucleoproteins ,Vaccines, Inactivated ,Commentary ,business ,Memory T cell ,Immunologic Memory ,CD8 ,T-Lymphocytes, Cytotoxic - Abstract
The threat of avian influenza A (H5N1) infection in humans remains a global health concern. Current influenza vaccines stimulate antibody responses against the surface glycoproteins but are ineffective against strains that have undergone significant antigenic variation. An alternative approach is to stimulate pre-existing memory T cells established by seasonal human influenza A infection that could cross-react with H5N1 by targeting highly conserved internal proteins. To determine how common cross-reactive T cells are, we performed a comprehensive ex vivo analysis of cross-reactive CD4+ and CD8+ memory T cell responses to overlapping peptides spanning the full proteome of influenza A/Viet Nam/CL26/2005 (H5N1) and influenza A/New York/232/2004 (H3N2) in healthy individuals from the United Kingdom and Viet Nam. Memory CD4+ and CD8+ T cells isolated from the majority of participants exhibited human influenza-specific responses and showed cross-recognition of at least one H5N1 internal protein. Participant CD4+ and CD8+ T cells recognized multiple synthesized influenza peptides, including peptides from the H5N1 strain. Matrix protein 1 (M1) and nucleoprotein (NP) were the immunodominant targets of cross-recognition. In addition, cross-reactive CD4+ and CD8+ T cells recognized target cells infected with recombinant vaccinia viruses expressing either H5N1 M1 or NP. Thus, vaccine formulas inducing heterosubtypic T cell-mediated immunity may confer broad protection against avian and human influenza A viruses.
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- 2016
40. Fabrication of high strength PA6/PP blends with pressure-induced-flow processing
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Fu, Dajiong, Kuang, Tairong, Chen, Feng, Lee, Ly James, and Peng, Xiangfang
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- 2015
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41. Aldehyde dehydrogenase 1 a1 regulates energy metabolism in adipocytes from different species
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Yang, Kefeng, primary, Adin, Christopher, additional, Shen, Qiwen, additional, Lee, Ly James, additional, Yu, Lianbo, additional, Fadda, Paolo, additional, Samogyi, Arpad, additional, Ham, Kathleen, additional, Xu, Lu, additional, Gilor, Chen, additional, and Ziouzenkova, Ouliana, additional
- Published
- 2017
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42. Improved sand erosion resistance and mechanical properties of multifunctional carbon nanofiber nanopaper‐enhanced fiber reinforced epoxy composites
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Zhang, Dan, primary, Cabrera, Eusebio, additional, Zhao, Yanan, additional, Zhao, Ziwei, additional, Castro, Jose M., additional, and Lee, Ly J., additional
- Published
- 2017
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43. Synthetic Melanin E-Ink
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Chang, Lingqian, primary, Chen, Feng, additional, Zhang, Xiaokang, additional, Kuang, Tairong, additional, Li, Mi, additional, Hu, Jiaming, additional, Shi, Junfeng, additional, Lee, Ly James, additional, Cheng, Huanyu, additional, and Li, Yiwen, additional
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- 2017
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44. Nanofabrication: Controllable Large-Scale Transfection of Primary Mammalian Cardiomyocytes on a Nanochannel Array Platform (Small 43/2016)
- Author
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Chang, Lingqian, primary, Gallego-Perez, Daniel, additional, Chiang, Chi-Ling, additional, Bertani, Paul, additional, Kuang, Tairong, additional, Sheng, Yan, additional, Chen, Feng, additional, Chen, Zhou, additional, Shi, Junfeng, additional, Yang, Hao, additional, Huang, Xiaomeng, additional, Malkoc, Veysi, additional, Lu, Wu, additional, and Lee, Ly James, additional
- Published
- 2016
- Full Text
- View/download PDF
45. Limited benefit of hepatitis B immunoglobulin prophylaxis in children of hepatitis B e antigen-negative mothers
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Lee, LY, primary, Aw, MM, additional, Saw, S, additional, Rauff, M, additional, Tong, PY, additional, and Lee, GH, additional
- Published
- 2016
- Full Text
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46. Improved sand erosion resistance and mechanical properties of multifunctional carbon nanofiber nanopaper‐enhanced fiber reinforced epoxy composites.
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Zhang, Dan, Cabrera, Eusebio, Zhao, Yanan, Zhao, Ziwei, Castro, Jose M., and Lee, Ly J.
- Subjects
CARBON nanofibers ,FIBROUS composites ,EPOXY resins ,SAND ,MECHANICAL behavior of materials ,GLASS fibers - Abstract
Abstract: Multifunctional carbon nanofiber (CNF) nanopaper‐enhanced glass fiber reinforced epoxy polymer composites (GFRPC) with improved sand erosion resistance, mechanical properties, and electromagnetic interference (EMI) shielding have been fabricated and tested in this work. Preformed CNF thin film or nanopaper, made of dense and entangled nanofiber networks, was molded on the surface of GFRPC as a surface protection layer by vacuum‐assisted resin transfer molding. A fivefold improvement in sand erosion resistance in terms of sand erosion rate, and up to 24% improvement in flexural strength were achieved after the incorporation of CNF nanopaper onto thin GFRPC. The CNF nanopaper‐enhanced GFRPC showed an EMI shielding of 33–40 dB within a frequency range of 30 MHz to 1.5 GHz. This multifunctional composite material shows good potential for use in wind power industry, commercial electronics housings, and the automotive industry. [ABSTRACT FROM AUTHOR]
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- 2018
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47. Chiix̱uu Tll iinasdll: Indigenous Ethics and Values Lead to Ecological Restoration for People and Place in Gwaii Haanas
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Lee, Lynn C., McNeill, Gwiisihlgaa Daniel, Ridings, Pauline, Featherstone, Mike, Okamoto, Daniel K., Spindel, Nathan B., Galloway, Aaron W.E., Saunders, Gary W., Adamczyk, Emily M., Reshitnyk, Luba, Pontier, Ondine, Post, Miranda, Irvine, Robyn, Wilson, Gulx̱a taa'a gaagii ng.aang Nadine, and Bellis, SG̱iids Ḵung Vanessa
- Published
- 2021
48. Controllable Large-Scale Transfection of Primary Mammalian Cardiomyocytes on a Nanochannel Array Platform
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Chang, Lingqian, primary, Gallego-Perez, Daniel, additional, Chiang, Chi-Ling, additional, Bertani, Paul, additional, Kuang, Tairong, additional, Sheng, Yan, additional, Chen, Feng, additional, Chen, Zhou, additional, Shi, Junfeng, additional, Yang, Hao, additional, Huang, Xiaomeng, additional, Malkoc, Veysi, additional, Lu, Wu, additional, and Lee, Ly James, additional
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- 2016
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49. Targeting the RAS/MAPK pathway withmiR-181ain acute myeloid leukemia
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Huang, Xiaomeng, primary, Schwind, Sebastian, additional, Santhanam, Ramasamy, additional, Eisfeld, Ann-Kathrin, additional, Chiang, Chi-ling, additional, Lankenau, Malori, additional, Yu, Bo, additional, Hoellerbauer, Pia, additional, Jin, Yan, additional, Tarighat, Somayeh S., additional, Khalife, Jihane, additional, Walker, Alison, additional, Perrotti, Danilo, additional, Bloomfield, Clara D., additional, Wang, Hongyan, additional, Lee, Robert J., additional, Lee, Ly James, additional, and Marcucci, Guido, additional
- Published
- 2016
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- View/download PDF
50. Application of DODMA and Derivatives in Cationic Nanocarriers for Gene Delivery
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Chen, Zhou, primary, Zhang, Aili, additional, Yang, Zhaogang, additional, Wang, Xinmei, additional, Chang, Lingqian, additional, Chen, Zhaofeng, additional, and James Lee, Ly, additional
- Published
- 2016
- Full Text
- View/download PDF
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