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The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics
Authors :
Abdallah J Abdul Ghani R Abdul Kadir K Abdullah R Abejuela Z Abraham O Abramowitz M Abusnana S Accini Mendoza JL Acosta I Agafyina A Aggarwal N Ahmed F Ahuad Guerrero RA Aiello J Ainsworth P Aizenberg D Akiyama H Akright L Akyea-Djamson A Alamartine E Alappan R Ali N Ali Z Alicic R Al-Karadsheh A Alpizar Salazar M Alvarez Garcia P Alvarisqueta A Amodeo C Andreeva V Andreotti Turatti LA Angelescu LM Angelova A Anghel V Antic S Aoki H Aquitania G Arauz-Pacheco C Arce-Nunez E Arcos Palma EG Arfeen S Arif A Aronson R Arutchelvam V Asano A Atray N Avram RI Awad A Baas Cruz J Babikova J Badat A Bajaj H Baker J Bakris G Barbarash O Barna O Barnard M Barranco E Barrera C Bartaskova D Bartolacci I Barysheva O Behara V Bellary S Belo D Bentley-Lewis R Benusova O Berenguer R Berli MA Bernardo M Biscoveanu M Bordonava AP Borot S Botsyurko V Bowman-Stroud C Brandon D Bregman R Brusco O Buganova I Burgos Soto M Busch R Busegeanu MM Calella P Camelo Sanches FC Canaan Y Canani LH Cantero MC Cariou B Cartasegna LR Castellino P Cereto Castro F Certow G Chacra AR Chae DW Chang CT Chang T Che Yusof MD Chen N Chen Q Cherney D Cheung NW Chevaile Ramos J Chew Wong A Chiovato L Chizhov D Cho YM Christiano C Christofides E Chuang LM Chuateco C Cif A Cigarran Guldris S Cohen K Cohen R Coloma GC Comia RS Commendatore V Conway J Cook C Cosma D Cournoyer S Coyne D Crisan C Csecsei G Csiky B Cuadrado J Cuneo CA Cunha Borges JL Cunha Vêncio SA Cusumano AM da Silva Franco RJ Daboul N Danos P DaRoza G Davies E Davies M Davies S Dawson A De Cosmo S De Nicola L De Serres S de Souza Portes E Deak L Deck K Deepak D Derosa G Desouza C Dev D Dhillon M DI CARLO, Alfonso Di Cianni G Diaz Escalante T Dimitrov S Distiller L Djordjevic M Dobronravov V Dohnalova L Dominguez Lopez M Douthat WG Dran RD Drasnar T Dreval A Droste C Dua S Dube F Dudar I Dudas M Dussol B Dzupina A Eder F Egido de Los Rios J El Kossi M El-Shahawy M English P Enriquez Sosa FE Ervin J Esquenazi A Evans J Faghih M Farias E Faulmann G Fauvel JP Ferariu IE Fernandez MF Fernandez Fresnedo G Fernandez Montenegro MA Finkelstein H Flores Lozano F Flota Cervera L Fraige Filho F Fraser D Frenk Baron P Fretes JO Frias J Fuiano G Fulop P Fushtey I Galan Serrano A Galphin C Gan S Gan CL Garcia NH Garcia I Garcia Ballesteros C Garcia Ortiz LH Garrido N Gastaldi A Gelersztein E Geloneze Neto B Genadieva V Genova-Hristova G Genovese S Ghazi A Giorda C Glenny JA Glinkina I Godlevska O Godoy Jorquera JG Goldenberg R Golovchenko O Gomes Bastos M Gomez O Gomez Rangel JD Gonzalez E Gonzalez Dorado A Gonzalez Martinez FJ Gonzalez Orellana RA Gopalakrishnan N Gorriz JL Gorson D Govender V Gracious N Greco B Gregar R Greloni GC Grineva E Guinsburg A Gulati R Gunstone A Gupta A Gupta M Gyrina O Hadjadj S Halciakova K Hall T Haller H Halmagyi I Hammoud J Hancu N Hanif W Hansraj A Hawley C Henein S Hermida S Hernandez Triana E Herrera Jimenez LE Hershon K Higuera Cobos JD Hiser D Hocking S Hon G Hristozov K Hsieh CH Hura C Hwang SJ Ilavska A Irizar Santana SS Ismail M Jackson A Jain D Jamal A Januszewicz A Jeong IK Jha V Jimenez Flores F Jodar Gimeno JE Johnson A Joseph F Joshi M Juncos LI Jurgens J Kajiyama S Kaminska A Kashine S Kaupke C Kawada T Keiko Kohara S Keitel E Keltai K Kendereski A Keresztesi S Kern E Kerr Saraiva JF Keshavamurthy CB Khandwala H Khanna R Khitan Z Khullar D Kim SG Kim YH Kim S Kiss K Klein A Klyver MI Kodera T Kolesnyk M Kolmakova E Komisarenko I Kong Y Kong WY Kono H Konyves L Kopyt N Korzh O Kovar R Kovesdy C Koyama K Kozloviene D Kraft F Krane V Kravchun N Krishna G Krishnan S Kropp JJ Kumar A Kumar J Kumeda Y Kumwenda M Kurtz Lisboa HR Kvitkova L Kwon HS Kwon MJ Lalic K Lalic N Lanchiotti PV Lastuvka J Laviada Molina H Lawrence M Le Meur Y Lee LY Lee BW Lee J Lee MK Legun O Leiter L Lentz J Leon de la Fuente RA Levin A Lewis D Li D Li W Li X Lim SK Lin H Lin CC Liss K Liu J Loh CL Lombard L Lopez Mendoza M Lopez Tarabay C Lorenzoni d'avila DO Loss de Carvalho Contieri F Lu W Lu YC Luna Ceballos R M. Edwin F MacDougall I Macedo de Souza PA Madej A Madore F Magalhaes Montenegro Junior R Mah PM Maheshwari H Major L Malberti F Malek Marin T Mandayam S Mandreoli M Manisha S Mankovskyy B Mannucci E Manocha AB Mao H Marar I Marasaev V Marchetta N Martin Del Campo Blanco B Martinka E Martynyuk L Maxeiner S Mazur S McMahon A Medina Farina M Mehta B Middleton J Mileder M Miyauchi S Mizuyama K Mkrtumyan A Mlodawska-Choluj D Molina de Salazar DI Molnar M Mookadam M Morales Franco G Morales Portillo C Mordujovich J Moreira de Brito C Moreira Diaz JP Moreno Loza OT Mostovoy Y Moustafa M Muirhead N Mujica Trenche S Munar Vila MA Munoz Torres M Munteanu M Mustieles Rocha C Nagibovich G Nam MS Narvarte J Nasser Hissa M Navickas A Nazario Sabbag ÂR Nedogoda S Negru D Newman G Ng KS Ngcakani N Nicholls K Nicol P Nieto Iglesias J Niiya T Nik Ahmad NNF Nisnisan J Nonchev B Noronha IL Nortje H Nossuli AK Nowicki M Obialo C Obrador Vera G Ochodnicka Z Oh KH Oishi H Olelewe S Oliver M Oosthuizen H Orio SI Orlowska-Kowalik G Oroszlan T Orozco Castellanos R Orsi E Ory I O'Shaughnessy A Ota S Otreras F Oviedo A Packham D Padron J Panarotto D Pankhaniya R Pantoja Perez J Paragh G Park CY Park SH Pashkovska N Patel D Patel G Pavon H Pei D Pella D Penfornis A Peralta Calcaneo J Pereira MA Pererva L Perez Vera M Peringat J Pertseva T Pesickova S Peterfai E Peterka K Petrica L Petro G Pettis K Pharr W Philip S Phillips A Piatti P Pichette V Pontiroli A Popa AR Popenda G Popovic-Radinovic V Portoles Perez JM Prasad N Proietto J Prozesky H Pumprla J Purighalla R Quesada Simon MA Quesada-Suarez L Rabasa-Lhoret R Ramirez Roca LA Ramtoola S Ranetti AE Rangelov R Ranjan R Raskina T Rastogi S Ratnasingam V Reddy J Ren Y Resk JH Rewerska B Reyes Rosano MA Rich L Rista L Roberts A Robinson M Rodelo J Rodriguez H Rodriguez Papini N Roger S Rosas S Rosas Guzman J Rosivall L Roussel R Rucker Joerg IE Rychlik I Saavedra Gajardo V Saavedra Sanchez SB Sala J Samoylov O Samoylova Y Sanchez Arenales JA Sanchez Mijangos JH Sanchez Polo JV Sankaram R Santoro D Santos JC Santos F Sarin R Saudek F Saumell F Saxena M Sazonova O Schiavi LB Schiller A Schuch T Scott R Scott D Seeber M Seiji Yamada S Sekkarie M Sensenbrenner J Serafinceanu C Serrano Sanson P Sessa H Shakeel M Shamkhalova M Shanik M Shaw S Sheu WH Shinkov A Shutemova E Silva Pecoits Filho RF Simo Canonge R Simoes de Almeida R Simon G Singh B Slompo Ramos C Smatanova I Smirnov I Smith S Smith Casabella T Soares Felicio J Soler Romeo MJ Solomon R Song W Soto Gonzalez A Sowinski D Sprague A Sree Bhushan R Sreedhar R Sreelatha M Steele A SPEDDING, Stephen John Strzelecka A Suchinda P Sudhakar B Sun J Sun L Surampudi P Sussman S Svyshchenko Y Symonds R Szlachcic Y Takacs R Takai M Tamayo Y. Orozco J Tan G Tellez Chavez E Temelkova M Terns Riera M Terront Lozano MA Tesar V Thompson M Tibes Hachmann JC Tinahones Madueno FJ Tolentino M Tomashkevych H Tomonaga O Topchii I Torshizi A Trespalacios F Trevisan R Trueba P Tryshchuk N Tseluyko V Tsujimoto M Tu P Turcios Juarez E Turner W Twahirwa M Ulla MR Updegrove J Urbanaviciene E Valderrama Cometa L Valdes Cepeda A Valenzuela A Valis M Vallejos A Vangel S Vannorsdall M Vargas Alonso RD Varghese F Vasas S Vazelov E Vejar M Velasquez-Mieyer P Velichkova E Velo M Venegas Carrillo L Vengadasalam P Ventrapragada S Villagordoa Mesa J Villarino AA Villegas I Visco VE Vizir V Vlasenko M Vyasam RC Wada T Wadud K Wahba M Wakasugi M Wakeling J Wakida Y WALKER, JOHN RICHARD Wang G Warren M Wassermann A Watanabe T Watson E Watts R Weiner P Weiner D Welsh J Wheeler D Williams M Winocour P Woo V Yamada M Yanagida K Yanase T Yang J Yao C Yap YE Ygpuara MDL Yin A Yoiti Hayashida C Yoon KH Young S Yu X Yumita W Yupanqui H Zaidman CJ Zamarripa Escobedo R Zanata Petry TB Zanella MT Zaoui P Zavaroni I Zemek S Zhang H Zhao M Zheng H Zlova T Zsom M Zykova T. Groningen Kidney Center (GKC) Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET) Abdallah, J Abdul Ghani, R Abdul Kadir, K Abdullah, R Abejuela, Z Abraham, O Abramowitz, M Abusnana, S Accini Mendoza, Jl Acosta, I Agafyina, A Aggarwal, N Ahmed, F Ahuad Guerrero, Ra Aiello, J Ainsworth, P Aizenberg, D Akiyama, H Akright, L Akyea-Djamson, A Alamartine, E Alappan, R Ali, N Ali, Z Alicic, R Al-Karadsheh, A Alpizar Salazar, M Alvarez Garcia, P Alvarisqueta, A Amodeo, C Andreeva, V Andreotti Turatti, La Angelescu, Lm Angelova, A Anghel, V Antic, S Aoki, H Aquitania, G Arauz-Pacheco, C Arce-Nunez, E Arcos Palma, Eg Arfeen, S Arif, A Aronson, R Arutchelvam, V Asano, A Atray, N Avram, Ri Awad, A Baas Cruz, J Babikova, J Badat, A Bajaj, H Baker, J Bakris, G Barbarash, O Barna, O Barnard, M Barranco, E Barrera, C Bartaskova, D Bartolacci, I Barysheva, O Behara, V Bellary, S Belo, D Bentley-Lewis, R Benusova, O Berenguer, R Berli, Ma Bernardo, M Biscoveanu, M Bordonava, Ap Borot, S Botsyurko, V Bowman-Stroud, C Brandon, D Bregman, R Brusco, O Buganova, I Burgos Soto, M Busch, R Busegeanu, Mm Calella, P Camelo Sanches, Fc Canaan, Y Canani, Lh Cantero, Mc Cariou, B Cartasegna, Lr Castellino, P Cereto Castro, F Certow, G Chacra, Ar Chae, Dw Chang, Ct Chang, T Che Yusof, Md Chen, N Chen, Q Cherney, D Cheung, Nw Chevaile Ramos, J Chew Wong, A Chiovato, L Chizhov, D Cho, Ym Christiano, C Christofides, E Chuang, Lm Chuateco, C Cif, A Cigarran Guldris, S Cohen, K Cohen, R Coloma, Gc Comia, R Commendatore, V Conway, J Cook, C Cosma, D Cournoyer, S Coyne, D Crisan, C Csecsei, G Csiky, B Cuadrado, J Cuneo, Ca Cunha Borges, Jl Cunha Vêncio, Sa Cusumano, Am da Silva Franco, Rj Daboul, N Danos, P Daroza, G Davies, E Davies, M Davies, S Dawson, A De Cosmo, S De Nicola, L De Serres, S de Souza Portes, E Deak, L Deck, K Deepak, D Derosa, G Desouza, C Dev, D Dhillon, M DI CARLO, Alfonso Di Cianni, G Diaz Escalante, T Dimitrov, S Distiller, L Djordjevic, M Dobronravov, V Dohnalova, L Dominguez Lopez, M Douthat, Wg Dran, Rd Drasnar, T Dreval, A Droste, C Dua, S Dube, F Dudar, I Dudas, M Dussol, B Dzupina, A Eder, F Egido de Los Rios, J El Kossi, M El-Shahawy, M English, P Enriquez Sosa, Fe Ervin, J Esquenazi, A Evans, J Faghih, M Farias, E Faulmann, G Fauvel, Jp Ferariu, Ie Fernandez, Mf Fernandez Fresnedo, G Fernandez Montenegro, Ma Finkelstein, H Flores Lozano, F Flota Cervera, L Fraige Filho, F Fraser, D Frenk Baron, P Fretes, Jo Frias, J Fuiano, G Fulop, P Fushtey, I Galan Serrano, A Galphin, C Gan, S Gan, Cl Garcia, Nh Garcia, I Garcia Ballesteros, C Garcia Ortiz, Lh Garrido, N Gastaldi, A Gelersztein, E Geloneze Neto, B Genadieva, V Genova-Hristova, G Genovese, S Ghazi, A Giorda, C Glenny, Ja Glinkina, I Godlevska, O Godoy Jorquera, Jg Goldenberg, R Golovchenko, O Gomes Bastos, M Gomez, O Gomez Rangel, Jd Gonzalez, E Gonzalez Dorado, A Gonzalez Martinez, Fj Gonzalez Orellana, Ra Gopalakrishnan, N Gorriz, Jl Gorson, D Govender, V Gracious, N Greco, B Gregar, R Greloni, Gc Grineva, E Guinsburg, A Gulati, R Gunstone, A Gupta, A Gupta, M Gyrina, O Hadjadj, S Halciakova, K Hall, T Haller, H Halmagyi, I Hammoud, J Hancu, N Hanif, W Hansraj, A Hawley, C Henein, S Hermida, S Hernandez Triana, E Herrera Jimenez, Le Hershon, K Higuera Cobos, Jd Hiser, D Hocking, S Hon, G Hristozov, K Hsieh, Ch Hura, C Hwang, Sj Ilavska, A Irizar Santana, S Ismail, M Jackson, A Jain, D Jamal, A Januszewicz, A Jeong, Ik Jha, V Jimenez Flores, F Jodar Gimeno, Je Johnson, A Joseph, F Joshi, M Juncos, Li Jurgens, J Kajiyama, S Kaminska, A Kashine, S Kaupke, C Kawada, T Keiko Kohara, S Keitel, E Keltai, K Kendereski, A Keresztesi, S Kern, E Kerr Saraiva, Jf Keshavamurthy, Cb Khandwala, H Khanna, R Khitan, Z Khullar, D Kim, Sg Kim, Yh Kim, S Kiss, K Klein, A Klyver, Mi Kodera, T Kolesnyk, M Kolmakova, E Komisarenko, I Kong, Y Kong, Wy Kono, H Konyves, L Kopyt, N Korzh, O Kovar, R Kovesdy, C Koyama, K Kozloviene, D Kraft, F Krane, V Kravchun, N Krishna, G Krishnan, S Kropp, Jj Kumar, A Kumar, J Kumeda, Y Kumwenda, M Kurtz Lisboa, Hr Kvitkova, L Kwon, H Kwon, Mj Lalic, K Lalic, N Lanchiotti, Pv Lastuvka, J Laviada Molina, H Lawrence, M Le Meur, Y Lee, Ly Lee, Bw Lee, J Lee, Mk Legun, O Leiter, L Lentz, J Leon de la Fuente, Ra Levin, A Lewis, D Li, D Li, W Li, X Lim, Sk Lin, H Lin, Cc Liss, K Liu, J Loh, Cl Lombard, L Lopez Mendoza, M Lopez Tarabay, C Lorenzoni d'avila, Do Loss de Carvalho Contieri, F Lu, W Lu, Yc Luna Ceballos, R M., Edwin F Macdougall, I Macedo de Souza, Pa Madej, A Madore, F Magalhaes Montenegro Junior, R Mah, Pm Maheshwari, H Major, L Malberti, F Malek Marin, T Mandayam, S Mandreoli, M Manisha, S Mankovskyy, B Mannucci, E Manocha, Ab Mao, H Marar, I Marasaev, V Marchetta, N Martin Del Campo Blanco, B Martinka, E Martynyuk, L Maxeiner, S Mazur, S Mcmahon, A Medina Farina, M Mehta, B Middleton, J Mileder, M Miyauchi, S Mizuyama, K Mkrtumyan, A Mlodawska-Choluj, D Molina de Salazar, Di Molnar, M Mookadam, M Morales Franco, G Morales Portillo, C Mordujovich, J Moreira de Brito, C Moreira Diaz, Jp Moreno Loza, Ot Mostovoy, Y Moustafa, M Muirhead, N Mujica Trenche, S Munar Vila, Ma Munoz Torres, M Munteanu, M Mustieles Rocha, C Nagibovich, G Nam, M Narvarte, J Nasser Hissa, M Navickas, A Nazario Sabbag, Âr Nedogoda, S Negru, D Newman, G Ng, K Ngcakani, N Nicholls, K Nicol, P Nieto Iglesias, J Niiya, T Nik Ahmad, Nnf Nisnisan, J Nonchev, B Noronha, Il Nortje, H Nossuli, Ak Nowicki, M Obialo, C Obrador Vera, G Ochodnicka, Z Oh, Kh Oishi, H Olelewe, S Oliver, M Oosthuizen, H Orio, Si Orlowska-Kowalik, G Oroszlan, T Orozco Castellanos, R Orsi, E Ory, I O'Shaughnessy, A Ota, S Otreras, F Oviedo, A Packham, D Padron, J Panarotto, D Pankhaniya, R Pantoja Perez, J Paragh, G Park, Cy Park, Sh Pashkovska, N Patel, D Patel, G Pavon, H Pei, D Pella, D Penfornis, A Peralta Calcaneo, J Pereira, Ma Pererva, L Perez Vera, M Peringat, J Pertseva, T Pesickova, S Peterfai, E Peterka, K Petrica, L Petro, G Pettis, K Pharr, W Philip, S Phillips, A Piatti, P Pichette, V Pontiroli, A Popa, Ar Popenda, G Popovic-Radinovic, V Portoles Perez, Jm Prasad, N Proietto, J Prozesky, H Pumprla, J Purighalla, R Quesada Simon, Ma Quesada-Suarez, L Rabasa-Lhoret, R Ramirez Roca, La Ramtoola, S Ranetti, Ae Rangelov, R Ranjan, R Raskina, T Rastogi, S Ratnasingam, V Reddy, J Ren, Y Resk, Jh Rewerska, B Reyes Rosano, Ma Rich, L Rista, L Roberts, A Robinson, M Rodelo, J Rodriguez, H Rodriguez Papini, N Roger, S Rosas, S Rosas Guzman, J Rosivall, L Roussel, R Rucker Joerg, Ie Rychlik, I Saavedra Gajardo, V Saavedra Sanchez, Sb Sala, J Samoylov, O Samoylova, Y Sanchez Arenales, Ja Sanchez Mijangos, Jh Sanchez Polo, Jv Sankaram, R Santoro, D Santos, Jc Santos, F Sarin, R Saudek, F Saumell, F Saxena, M Sazonova, O Schiavi, Lb Schiller, A Schuch, T Scott, R Scott, D Seeber, M Seiji Yamada, S Sekkarie, M Sensenbrenner, J Serafinceanu, C Serrano Sanson, P Sessa, H Shakeel, M Shamkhalova, M Shanik, M Shaw, S Sheu, Wh Shinkov, A Shutemova, E Silva Pecoits Filho, Rf Simo Canonge, R Simoes de Almeida, R Simon, G Singh, B Slompo Ramos, C Smatanova, I Smirnov, I Smith, S Smith Casabella, T Soares Felicio, J Soler Romeo, Mj Solomon, R Song, W Soto Gonzalez, A Sowinski, D Sprague, A Sree Bhushan, R Sreedhar, R Sreelatha, M Steele, A Spedding, Stephen John Strzelecka, A Suchinda, P Sudhakar, B Sun, J Sun, L Surampudi, P Sussman, S Svyshchenko, Y Symonds, R Szlachcic, Y Takacs, R Takai, M Tamayo Y., Orozco J Tan, G Tellez Chavez, E Temelkova, M Terns Riera, M Terront Lozano, Ma Tesar, V Thompson, M Tibes Hachmann, Jc Tinahones Madueno, Fj Tolentino, M Tomashkevych, H Tomonaga, O Topchii, I Torshizi, A Trespalacios, F Trevisan, R Trueba, P Tryshchuk, N Tseluyko, V Tsujimoto, M Tu, P Turcios Juarez, E Turner, W Twahirwa, M Ulla, Mr Updegrove, J Urbanaviciene, E Valderrama Cometa, L Valdes Cepeda, A Valenzuela, A Valis, M Vallejos, A Vangel, S Vannorsdall, M Vargas Alonso, Rd Varghese, F Vasas, S Vazelov, E Vejar, M Velasquez-Mieyer, P Velichkova, E Velo, M Venegas Carrillo, L Vengadasalam, P Ventrapragada, S Villagordoa Mesa, J Villarino, Aa Villegas, I Visco, Ve Vizir, V Vlasenko, M Vyasam, Rc Wada, T Wadud, K Wahba, M Wakasugi, M Wakeling, J Wakida, Y Walker, JOHN RICHARD Wang, G Warren, M Wassermann, A Watanabe, T Watson, E Watts, R Weiner, P Weiner, D Welsh, J Wheeler, D Williams, M Winocour, P Woo, V Yamada, M Yanagida, K Yanase, T Yang, J Yao, C Yap, Ye Ygpuara, Mdl Yin, A Yoiti Hayashida, C Yoon, Kh Young, S Yu, X Yumita, W Yupanqui, H Zaidman, Cj Zamarripa Escobedo, R Zanata Petry, Tb Zanella, Mt Zaoui, P Zavaroni, I Zemek, S Zhang, H Zhao, M Zheng, H Zlova, T Zsom, M Zykova, T.
Source :
American Journal of Nephrology, 46(6), 462-472. KARGER, AMERICAN JOURNAL OF NEPHROLOGY, r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA, instname
Publication Year :
2017
Abstract
Background: People with diabetes and kidney disease have a high risk of cardiovascular events and progression of kidney disease. Sodium glucose co-transporter 2 inhibitors lower plasma glucose by reducing the uptake of filtered glucose in the kidney tubule, leading to increased urinary glucose excretion. They have been repeatedly shown to induce modest natriuresis and reduce HbA1c, blood pressure, weight, and albuminuria in patients with type 2 diabetes. However, the effects of these agents on kidney and cardiovascular events have not been extensively studied in patients with type 2 diabetes and established kidney disease. Methods: The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial aims to compare the efficacy and safety of canagliflozin ­versus placebo at preventing clinically important kidney and cardiovascular outcomes in patients with diabetes and established kidney disease. CREDENCE is a randomized, double-blind, event-driven, placebo-controlled trial set in in 34 countries with a projected duration of ∼5.5 years and enrolling 4,401 adults with type 2 diabetes, estimated glomerular filtration rate ≥30 to 2, and albuminuria (urinary albumin:creatinine ratio >300 to ≤5,000 mg/g). The study has 90% power to detect a 20% reduction in the risk of the primary outcome (α = 0.05), the composite of end-stage kidney disease, doubling of serum creatinine, and renal or cardiovascular death. Conclusion: CREDENCE will provide definitive evidence about the effects of canagliflozin on renal (and cardiovascular) outcomes in patients with type 2 diabetes and established kidney disease. Trial Registration: EudraCT number: 2013-004494-28; ClinicalTrials.gov identifier: NCT02065791.
Details
Language :
English
ISSN :
02508095
Database :
OpenAIRE
Journal :
American Journal of Nephrology, 46(6), 462-472. KARGER, AMERICAN JOURNAL OF NEPHROLOGY, r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA, instname
Accession number :
edsair.doi.dedup.....3150a4589d029408893a3870ee0bbdd3