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Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
Authors :
Perkovic, V. Jardine, M. J. Neal, B. Bompoint, S. Heerspink, H. J. L. Charytan, D. M. Edwards, R. Agarwal, R. Bakris, G. Bull, S. Cannon, C. P. Capuano, G. Chu, P. -L. De Zeeuw, D. Greene, T. Levin, A. Pollock, C. Wheeler, D. C. Yavin, Y. Zhang, H. Zinman, B. Meininger, G. Brenner, B. M. Mahaffey, K. W. Perkovic, V Mahaffey, Kw Agarwal, R Bakris, G Brenner, Bm Cannon, Cp Charytan, Dm de Zeeuw, D Greene, T Jardine, Mj Heerspink, Hjl Levin, A Meininger, G Neal, B Pollock, C Wheeler, Dc Zhang, H Zinman, B Mcguire, Dk Holman, R Home, P Scharfstein, D Parfrey, P Shahinfar, S August, P Chang, T Sinha, Ad Januzzi, J Kolansky, D Amerena, J Hillis, G Gorelick, P Kissela, B Kasner, S Lindley, R Fulcher, G Ounadjela, S Hufert, K von Ingersleben, G Gaglia, J Harris, R Hudson, M Turchin, A Cheifetz, A Sheth, S Feuerstein, J Cohen, S Jardine, M Li, N Kolesnyk, I Aizenberg, D Pecoits-Filho, R Cherney, D 3rd Obrador, G Chertow, G Hawley, C Ji, L Wada, T Jha, V Lim, Sk Lim-Abrahan, Ma Santos, F Chae, Dw Hwang, Sj Vazelov, E Rychlík, I Hadjadj, S Krane, V Rosivall, L De Nicola, L Dreval, A Nowicki, M Schiller, A Distiller, L Górriz, Jl Kolesnyk, M Morren, F Goykhman, S David, C Yost, L Wang, H Hettiarachchi, M Thimmaiah, R Koppolu, D George, S Schmidt, M Ignjatovic, J Chapin, L Travis, K Destree, M Sood, V Coffee, L De Brouwer, K Zaviriukha, V Starzec, A Koizumi, M Lin, G Chen, E Lin, P Leia, C Mascaro, D Amigo, A Limos, A Abrahamsen, I Jaffer, S Ahuad Guerrero RA Albisu, Jp Alvarisqueta, A Bartolacci, I Berli, Ma Bordonava, A Calella, P Cantero, Mc Cartasegna, Lr Cercos, E Coloma, Gc Colombo, H Commendatore, V Cuadrado, J Cuneo, Ca Cusumano, Am Douthat, Wg Dran, Rd Farias, E Fernandez, Mf Finkelstein, H Fragale, G Fretes, Jo Garcia, Nh Gastaldi, A Gelersztein, E Glenny, Ja Gonzalez, Jp Gonzalez Colaso PDC Goycoa, C Greloni, Gc Guinsburg, A Hermida, S Juncos, Li Klyver, Mi Kraft, F Krynski, F Lanchiotti, Pv Leon de la Fuente RA Marchetta, N Mele, P Nicolai, S Novoa, Pa Orio, Si Otreras, F Oviedo, A Raffaele, P Resk, Jh Rista, L Rodriguez Papini, N Sala, J Santos, Jc Schiavi, Lb Sessa, H Smith Casabella, T Ulla, Mr Valdez, M Vallejos, A Villarino, A Visco, Ve Wassermann, A Zaidman, Cj Cheung, Nw Droste, C Fraser, I Johnson, D Mah, Pm Nicholls, K Packham, D Proietto, J Roberts, A Roger, S Tsang, V Raduan, Ra Alves da Costa FA Amodeo, C Andreotti Turatti LA Bregman, R Camelo Sanches FC Canani, Lh Chacra, Ar Cunha Borges JL Cunha Vêncio SA da Silva Franco RJ D'Avila, D de Souza Portes, E de Souza, P Deboni, Lm Filho, Ff Geloneze Neto, B Gomes, M Kohara, Sk Keitel, E Kerr Saraiva JF Kurtz Lisboa HR de Carvalho Contieri FL Milagres, R Montenegro Junior, R Moreira de Brito, C Nazzer Hissa, M Nazario Sabbag ÂR Noronha, I Panarotto, D Pecoits Filho, R Pereira, Ma Saporito, W Scotton, As Schuch, T Simões de Almeida, R Slompo Ramos, C Soares Felício, J Thomé, F Tibes Hachmann JC Yamada, S Yoiti Hayashida, C Zanata Petry TB Zanella, Mt Andreeva, V Angelova, A Dimitrov, S Genadieva, V Genova-Hristova, G Hristozov, K Kamenov, Z Koundurdjiev, A Lozanov, L Margaritov, V Nonchev, B Rangelov, R Shinkov, A Temelkova, M Velichkova, E Yakov, A Aggarwal, N Aronson, R Bajaj, H Chouinard, G Conway, J Cournoyer, S Daroza, G De Serres, S Dubé, F Goldenberg, R Gupta, A Gupta, M Henein, S Khandwala, H Leiter, L Madore, F Mcmahon, A Muirhead, N Pichette, V Rabasa-Lhoret, R Steele, A Tangri, N Torshizi, A Woo, V Zalunardo, N Fernández Montenegro MA Godoy Jorquera JG Medina Fariña, M Saavedra Gajardo, V Vejar, M Chen, N Chen, Q Gan, S Kong, Y Li, D Li, W Li, X Lin, H Liu, J Lu, W Mao, H Ren, Y Song, W Sun, J Sun, L Tu, P Wang, G Yang, J Yin, A Yu, X Zhao, M Zheng, H Accini Mendoza JL Arcos, E Avendano, J Diaz Ruiz JEA Garcia Ortiz LH Gonzalez, A Hernandez Triana, E Higuera, Jd Malaver, N Molina de Salazar DI Rosero, R Terront Lozano MA Valderrama Cometa, L Valenzuela, A Vargas Alonso RD Villegas, I Yupanqui, H Bartaskova, D Barton, P Belobradkova, J Dohnalova, L Drasnar, T Ferkl, R Halciakova, K Klokocnikova, V Kovar, R Lastuvka, J Lukac, M Pesickova, S Peterka, K Pumprla, J Rychlik, I Saudek, F Tesar, V Valis, M Weiner, P Zemek, S Alamartine, E Borot, S Cariou, B Dussol, B Fauvel, Jp Gourdy, P Klein, A Le Meur, Y Penfornis, A Roussel, R Saulnier, Pj Thervet, E Zaoui, P Burst, V Faghih, M Faulmann, G Haller, H Jerwan-Keim, R Maxeiner, S Paschen, B Plassmann, G Rose, L Gonzalez Orellana RA Haase, Fp Moreira Diaz JP Ramirez Roca LA Sánchez Arenales JA Sanchez Polo JV Turcios Juarez, E Csecsei, G Csiky, B Danos, P Deak, L Dudas, M Harcsa, E Keltai, K Keresztesi, S Kiss, K Konyves, L Major, L Mileder, M Molnar, M Mucsi, J Oroszlan, T Ory, I Paragh, G Peterfai, E Petro, G Revesz, K Takacs, R Vangel, S Vasas, S Zsom, M Abraham, O Bhushan, Rs Deepak, D Edwin, Fm Gopalakrishnan, N Gracious, N Hansraj, A Jain, D Keshavamurthy, Cb Khullar, D Manisha, S Peringat, J Prasad, N Satyanarayana, Rk Sreedhar, R Sreelatha, M Sudhakar, B Vyasam, Rc Bonadonna, R Castellino, P Ceriello, A Chiovato, L De Cosmo, S Derosa, G Di Carlo, A Di Cianni, G Frascà, G Fuiano, G Gambaro, G Garibotto, G Giorda, C Malberti, F Mandreoli, M Mannucci, E Orsi, E Piatti, P Santoro, D Sasso, Fc Serviddio, G Stella, A Trevisan, R Veronelli, Am Zanoli, L Akiyama, H Aoki, H Asano, A Iitsuka, T Kajiyama, S Kashine, S Kawada, T Kodera, T Kono, H Koyama, K Kumeda, Y Miyauchi, S Mizuyama, K Niiya, T Oishi, H Ota, S Sakakibara, T Takai, M Tomonaga, O Tsujimoto, M Wakasugi, M Wakida, Y Watanabe, T Yamada, M Yanagida, K Yanase, T Yumita, W Gaupsiene, E Kozloviene, D Navickas, A Urbanaviciene, E Abdul Ghani, R Abdul Kadir, K Ali, N Che Yusof MD Gan, Cl Ismail, M Kong, Wy Lam, Sw Lee, Ly Loh, Cl Manocha, Ab Ng, Ks Nik Ahmad NNF Ratnasingam, V Bin Shudim SS Vengadasalam, P Abraira Munoz LD Salazar, Ma Cruz, Jb Soto, Mb Ramos, Jc Wong, Ac Correa Rotter JR Diaz Escalante, T Enriquez Sosa FE Flores Lozano, F Flota Cervera LF Frenk Baron, P Garcia Ballesteros, C Gomez Rangel JD Herrera Jimenez LE Irizar Santana SS Jimenez Florez, F Laviada Molina, H Luna Ceballos RI Martin Del Camp Blanco, B Morales Franco, G Moreno Loza OT Mustieles Rocha, C Obrador Vera, G Orozco Castellanos, R Peralta Calcaneo, J Reyes Rosano MA Rodriguez Pattzi, H Rosas Guzman, J Rucker Joerg IE Saaveddra Sanchez SB Sanchez Mijangos JH Serrano Sanson, P Tamayo, Y Orozco JA Tellez Chavez, E Valdes Depeda, A Venegas Carrillo, L Villagordoa Mesa, J Zamarripa Escobedo, R Baker, J Noonan, P Scott, R Walker, R Watson, E Williams, M Young, S Abejuela, Z Agra, J Aquitania, G Caringal, C Comia, Rs Delos Santos, L Gomez, O Jimeno, C Tan, G Tolentino, M Yao, C Yap, Ye Ygpuara, Mdl Bijata-Bronisz, R Hotlos, L Januszewicz, A Kaczmarek, B Kaminska, A Lazuka, L Madej, A Mazur, S Mlodawska-Choluj, D Orlowska-Kowalik, G Popenda, G Rewerska, B Sowinski, D Angelescu, Lm Anghel, V Avram, Ri Busegeanu, Mm Cif, A Cosma, D Crisan, C Demian, Ld Ferariu, Ie Halmagyi, I Hancu, N Munteanu, M Negru, D Onaca, Ag Petrica, L Popa, Ar Ranetti, Ae Serafinceanu, C Toarba, C Agafyina, A Barbarash, O Barysheva, O Chizhov, D Dobronravov, V Glinkina, I Grineva, E Khirmanov, V Kolmakova, E Koroleva, T Kvitkova, L Marasaev, V Mkrtumyan, A Morugova, T Nagibovich, G Nagibovich, O Nedogoda, S Osipova, I Raskina, T Samoylova, Y Sazonova, O Shamkhalova, M Shutemova, E Shwartz, Y Uriasyev, O Vorobyev, S Zateyshchikova, A Zateyshshikov, D Zykova, T Antic, S Djordjevic, M Kendereski, A Lalic, K Lalic, N Popovic-Radinovic, V Babikova, J Benusova, O Buganova, I Culak, J Dzupina, A Dzuponova, J Fulop, P Ilavska, A Martinka, E Ochodnicka, Z Pella, D Smatanova, I Ahmed, F Badat, A Breedt, J Govender, V Govender, R Joshi, M Jurgens, J Latiff, G Lombard, L Mookadam, M Ngcakani, N Nortje, H Oosthuizen, H Pillay-Ramaya, L Prozesky, H Reddy, J Rheeder, P Seeber, M Cho, Ym Jeong, Ik Kim, Sg Kim, Yh Kwon, Hs Kwon, Mj Lee, Bw Lee, J Lee, Mk Nam, Ms Oh, Kh Park, Cy Park, Sh Yoon, Kh Alvarez Garcia, P Asmarats Mercadal, L Barrios, C Cereto Castro, F Cigarran Guldris, S Dominquez Lopez, M Egido de Los Rios, J Fernandez Fresnedo, G Galan Serrano, A Garcia, I Gonzalez Martinez FJ Jodar Gimeno JE Muñoz Lopez Mendoza, M Malek Marin, T Morales Portillo, C Munar Vila MA Muñoz Torres, M Nieto Iglesias, J Pantoja Perez, J Perez Vera, M Portoles Perez JM Quesada Simón MA Simo Canonge, R Soto Gonzalez, A Terns Riera, M Tinahones Madueno FJ Plaza, Mv Chang, Ct Chuang, Lm Hsia, Tl Hsieh, Ch Lin, Cc Lu, Yc Sheu, Wh Barna, O Bilyk, Sd Botsyurko, V Dudar, I Fushtey, I Godlevska, O Golovchenko, O Gyrina, O Kazmirchuk, A Komisarenko, I Korzh, O Kravchun, N Legun, O Mankovskyy, B Martynyuk, L Mostovoy, Y Pashkovska, N Pererva, L Pertseva, T Samoylov, O Smirnov, I Svyshchenko, Y Tomashkevych, H Topchii, I Tryshchuk, N Tseluyko, V Vizir, V Vlasenko, M Zlova, T Zub, L Abusnana, S Railey, M Abouglila, K Ainsworth, P Ali, Z Arutchelvam, V Barnard, M Bellary, S Davies, E Davies, M Davies, S Dawson, A El Kossi, M English, P Fraser, D Gnudi, L Gunstone, A Hall, T Hanif, W Jackson, A Johnson, A Joseph, F Krishnan, S Kumwenda, M Macdougall, I Nixon, P O'Hare, J Philip, S Ramtoola, S Saxena, M Sennik, D Simon, G Singh, B Stephens, J Strzelecka, A Symonds, R Turner, W Wahba, M Wakeling, J Wheeler, D Winocour, P Abdallah, J Abdullah, R Abramowitz, M Acosta, I Aiello, J Akright, L Akyea-Djamson, A Alappan, R Alicic, R Al-Karadsheh, A Allison, Dc Arauz-Pacheco, C Arfeen, S Arif, A Arvind, M Atray, N Awad, A Barnhill, P Barranco, E Barrera, C Beacom, M Behara, V Belo, D Bentley-Lewis, R Berenguer, R Bermudez, L Bernardo, M Biscoveanu, M Bowman-Stroud, C Brandon, D Brusco, O Busch, R Canaan, Y Chilito, A Christensen, T Christiano, C Christofides, E Chuateco, C Cohen, K Cohen, R Cohen-Stein, D Cook, C Coyne, D Daboul, N Darwish, R Daswani, A Deck, K Desouza, C Dev, D Dhillon, M Dua, S Eder, F Elosegui, Am El-Shahawy, M Ervin, J Esquenazi, A Evans, J Fishbane, S Frias, J Galindo-Ramos, E Galphin, C Ghazi, A Gonzalez, E Gorson, D Gowda, A Greco, B Grubb, S Gulati, R Hammoud, J Handelsman, S Hartman, I Hershon, K Hiser, D Hon, G Jacob, R Jaime, M Jamal, A Kaupke, C Keightley, G Kern, E Khanna, R Khitan, Z Kim, S Kopyt, N Kovesdy, C Krishna, G Kropp, J Kumar, A Kumar, J Kumar, N Kusnir, J Lane, W Lawrence, M Lehrner, L Lentz, J Levinson, D Lewis, D Liss, K Maddux, A Maheshwari, H Mandayam, S Marar, I Mehta, B Middleton, J Mordujovich, J Moreda, R Moustafa, M Mujica Trenche, S Narayanan, M Narvarte, J Nassar, T Newman, G Nichol, B Nicol, P Nisnisan, J Nossuli, Ak Obialo, C Olelewe, S Oliver, M O'Shaughnessy, A Padron, J Pankhaniya, R Parker, R Patel, D Patel, G Patel, N Pavon, H Perez, A Perez, C Perlman, A Pettis, K Pharr, W Phillips, A Purighalla, R Quesada-Suarez, L Ranjan, R Rastogi, S Rendell, M Rich, L Robinson, M Rodriguez, H Rosas, S Saba, F Sankaram, R Sarin, R Schreiman, R Scott, D Sekkarie, M Sensenbrenner, J Shakeel, M Shanik, M Shaw, S Smith, S Solomon, R Sprague, A Spry, L Suchinda, P Sultan, S Surampudi, P Sussman, S Tan, A Terrelonge, A Thompson, M Trespalacios, F Trippe, B Trueba, P Twahirwa, M Updegrove, J Van Buren, P Vannorsdall, M Varghese, F Velasquez-Mieyer, P Ventrapragada, S Vukotic, G Wadud, K Warren, M Watson, H Watts, R Weiner, D Welker, J Welsh, J Williams, S Zaniewski-Singh, M. Perkovic, Vlado Jardine, Meg J Neal, Bruce Bompoint, Severine Heerspink, Hiddo J L Charytan, David M Edwards, Robert Agarwal, Rajiv Bakris, George Bull, Scott Cannon, Christopher P Capuano, George Chu, Pei-Ling de Zeeuw, Dick Greene, Tom Levin, Adeera Pollock, Carol Wheeler, David C Yavin, Yshai Zhang, Hong Zinman, Bernard Meininger, Gary Brenner, Barry M Mahaffey, Kenneth W collaborator: Perkovic, V Mahaffey, Kw Agarwal, R Bakris, G Brenner, Bm Cannon, Cp Charytan, Dm de Zeeuw, D Greene, T Jardine, Mj Heerspink, Hjl Levin, A Meininger, G Neal, B Pollock, C Wheeler, Dc Zhang, H Zinman, B Mcguire, Dk Holman, R Home, P Scharfstein, D Parfrey, P Shahinfar, S August, P Chang, T Sinha, Ad Januzzi, J Kolansky, D Amerena, J Hillis, G Gorelick, P Kissela, B Kasner, S Lindley, R Fulcher, G Ounadjela, S Hufert, K von Ingersleben, G Gaglia, J Harris, R Hudson, M Turchin, A Cheifetz, A Sheth, S Feuerstein, J Cohen, S Jardine, M Li, N Kolesnyk, I Aizenberg, D Pecoits-Filho, R Cherney, D 3rd Obrador, G Chertow, G Hawley, C Ji, L Wada, T Jha, V Lim, Sk Lim-Abrahan, Ma Santos, F Chae, Dw Hwang, Sj Vazelov, E Rychlík, I Hadjadj, S Krane, V Rosivall, L De Nicola, L Dreval, A Nowicki, M Schiller, A Distiller, L Górriz, Jl Kolesnyk, M Morren, F Goykhman, S David, C Yost, L Wang, H Hettiarachchi, M Thimmaiah, R Koppolu, D George, S Schmidt, M Ignjatovic, J Chapin, L Travis, K Destree, M Sood, V Coffee, L De Brouwer, K Zaviriukha, V Starzec, A Koizumi, M Lin, G Chen, E Lin, P Leia, C Mascaro, D Amigo, A Limos, A Abrahamsen, I Jaffer, S Ahuad Guerrero, Ra Albisu, Jp Alvarisqueta, A Bartolacci, I Berli, Ma Bordonava, A Calella, P Cantero, Mc Cartasegna, Lr Cercos, E Coloma, Gc Colombo, H Commendatore, V Cuadrado, J Cuneo, Ca Cusumano, Am Douthat, Wg Dran, Rd Farias, E Fernandez, Mf Finkelstein, H Fragale, G Fretes, Jo Garcia, Nh Gastaldi, A Gelersztein, E Glenny, Ja Gonzalez, Jp Gonzalez Colaso, Pdc Goycoa, C Greloni, Gc Guinsburg, A Hermida, S Juncos, Li Klyver, Mi Kraft, F Krynski, F Lanchiotti, Pv Leon de la Fuente, Ra Marchetta, N Mele, P Nicolai, S Novoa, Pa Orio, Si Otreras, F Oviedo, A Raffaele, P Resk, Jh Rista, L Rodriguez Papini, N Sala, J Santos, Jc Schiavi, Lb Sessa, H Smith Casabella, T Ulla, Mr Valdez, M Vallejos, A Villarino, A Visco, Ve Wassermann, A Zaidman, Cj Cheung, Nw Droste, C Fraser, I Johnson, D Mah, Pm Nicholls, K Packham, D Proietto, J Roberts, A Roger, S Tsang, V Raduan, Ra Alves da Costa, Fa Amodeo, C Andreotti Turatti, La Bregman, R Camelo Sanches, Fc Canani, Lh Chacra, Ar Cunha Borges, Jl Cunha Vêncio, Sa da Silva Franco, Rj D'Avila, D de Souza Portes, E de Souza, P Deboni, Lm Filho, Ff Geloneze Neto, B Gomes, M Kohara, Sk Keitel, E Kerr Saraiva, Jf Kurtz Lisboa, Hr de Carvalho Contieri, Fl Milagres, R Montenegro Junior, R Moreira de Brito, C Nazzer Hissa, M Nazario Sabbag, Âr Noronha, I Panarotto, D Pecoits Filho, R Pereira, Ma Saporito, W Scotton, A Schuch, T Simões de Almeida, R Slompo Ramos, C Soares Felício, J Thomé, F Tibes Hachmann, Jc Yamada, S Yoiti Hayashida, C Zanata Petry, Tb Zanella, Mt Andreeva, V Angelova, A Dimitrov, S Genadieva, V Genova-Hristova, G Hristozov, K Kamenov, Z Koundurdjiev, A Lozanov, L Margaritov, V Nonchev, B Rangelov, R Shinkov, A Temelkova, M Velichkova, E Yakov, A Aggarwal, N Aronson, R Bajaj, H Chouinard, G Conway, J Cournoyer, S Daroza, G De Serres, S Dubé, F Goldenberg, R Gupta, A Gupta, M Henein, S Khandwala, H Leiter, L Madore, F Mcmahon, A Muirhead, N Pichette, V Rabasa-Lhoret, R Steele, A Tangri, N Torshizi, A Woo, V Zalunardo, N Fernández Montenegro, Ma Godoy Jorquera, Jg Medina Fariña, M Saavedra Gajardo, V Vejar, M Chen, N Chen, Q Gan, S Kong, Y Li, D Li, W Li, X Lin, H Liu, J Lu, W Mao, H Ren, Y Song, W Sun, J Sun, L Tu, P Wang, G Yang, J Yin, A Yu, X Zhao, M Zheng, H Accini Mendoza, Jl Arcos, E Avendano, J Diaz Ruiz, Jea Garcia Ortiz, Lh Gonzalez, A Hernandez Triana, E Higuera, Jd Malaver, N Molina de Salazar, Di Rosero, R Terront Lozano, Ma Valderrama Cometa, L Valenzuela, A Vargas Alonso, Rd Villegas, I Yupanqui, H Bartaskova, D Barton, P Belobradkova, J Dohnalova, L Drasnar, T Ferkl, R Halciakova, K Klokocnikova, V Kovar, R Lastuvka, J Lukac, M Pesickova, S Peterka, K Pumprla, J Rychlik, I Saudek, F Tesar, V Valis, M Weiner, P Zemek, S Alamartine, E Borot, S Cariou, B Dussol, B Fauvel, Jp Gourdy, P Klein, A Le Meur, Y Penfornis, A Roussel, R Saulnier, Pj Thervet, E Zaoui, P Burst, V Faghih, M Faulmann, G Haller, H Jerwan-Keim, R Maxeiner, S Paschen, B Plassmann, G Rose, L Gonzalez Orellana, Ra Haase, Fp Moreira Diaz, Jp Ramirez Roca, La Sánchez Arenales, Ja Sanchez Polo, Jv Turcios Juarez, E Csecsei, G Csiky, B Danos, P Deak, L Dudas, M Harcsa, E Keltai, K Keresztesi, S Kiss, K Konyves, L Major, L Mileder, M Molnar, M Mucsi, J Oroszlan, T Ory, I Paragh, G Peterfai, E Petro, G Revesz, K Takacs, R Vangel, S Vasas, S Zsom, M Abraham, O Bhushan, R Deepak, D Edwin, Fm Gopalakrishnan, N Gracious, N Hansraj, A Jain, D Keshavamurthy, Cb Khullar, D Manisha, S Peringat, J Prasad, N Satyanarayana, Rk Sreedhar, R Sreelatha, M Sudhakar, B Vyasam, Rc Bonadonna, R Castellino, P Ceriello, A Chiovato, L De Cosmo, S Derosa, G Di Carlo, A Di Cianni, G Frascà, G Fuiano, G Gambaro, G Garibotto, G Giorda, C Malberti, F Mandreoli, M Mannucci, E Orsi, E Piatti, P Santoro, D Sasso, Fc Serviddio, G Stella, A Trevisan, R Veronelli, Am Zanoli, L Akiyama, H Aoki, H Asano, A Iitsuka, T et al Groningen Kidney Center (GKC) Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)
Source :
NEW ENGLAND JOURNAL OF MEDICINE, r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA, instname, New England Journal of Medicine, 380(24), 2295-2306. MASSACHUSETTS MEDICAL SOC
Publication Year :
2019
Abstract
BACKGROUND: Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS: In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin-angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of
Details
ISSN :
15334406 and 00284793
Volume :
380
Issue :
24
Database :
OpenAIRE
Journal :
The New England journal of medicine
Accession number :
edsair.doi.dedup.....69fdb280519f3278698922ae350aabdb