Search

Your search keyword '"Lazzerini, M"' showing total 250 results
Start Over Author "Lazzerini, M"
250 results on '"Lazzerini, M"'

1. Health workers' perspectives on the quality of maternal and newborn health care around the time of childbirth: Results of the Improving MAternal Newborn carE in the EURO Region (IMAgiNE EURO) project in 12 countries of the World Health Organization European Region

Author

Valente, E, Mariani, I, Bomben, A, Morano, S, Gemperle, M, Otelea, M, Miani, C, Elden, H, Sarantaki, A, Costa, R, Baranowska, B, Konig-Bachmann, M, Kongslien, S, Drandic, D, Rozee, V, Nespoli, A, Abderhalden-Zellweger, A, Nanu, I, Batram-Zantvoort, S, Linden, K, Metallinou, D, Dias, H, Tataj-Puzyna, U, D'Costa, E, Nedberg, I, Kurbanovic, M, de La Rochebrochard, E, Fumagalli, S, Grylka-Baeschlin, S, Handra, C, Zaigham, M, Orovou, E, Barata, C, Szlendak, B, Zenzmaier, C, Vik, E, Liepinaitiene, A, Drglin, Z, Arendt, M, Sacks, E, Lazzerini, M, Valente E. P., Mariani I., Bomben A., Morano S., Gemperle M., Otelea M. R., Miani C., Elden H., Sarantaki A., Costa R., Baranowska B., Konig-Bachmann M., Kongslien S., Drandic D., Rozee V., Nespoli A., Abderhalden-Zellweger A., Nanu I., Batram-Zantvoort S., Linden K., Metallinou D., Dias H., Tataj-Puzyna U., D'Costa E., Nedberg I. H., Kurbanovic M., de La Rochebrochard E., Fumagalli S., Grylka-Baeschlin S., Handra C. M., Zaigham M., Orovou E., Barata C., Szlendak B., Zenzmaier C., Vik E. S., Liepinaitiene A., Drglin Z., Arendt M., Sacks E., Lazzerini M., Valente, E, Mariani, I, Bomben, A, Morano, S, Gemperle, M, Otelea, M, Miani, C, Elden, H, Sarantaki, A, Costa, R, Baranowska, B, Konig-Bachmann, M, Kongslien, S, Drandic, D, Rozee, V, Nespoli, A, Abderhalden-Zellweger, A, Nanu, I, Batram-Zantvoort, S, Linden, K, Metallinou, D, Dias, H, Tataj-Puzyna, U, D'Costa, E, Nedberg, I, Kurbanovic, M, de La Rochebrochard, E, Fumagalli, S, Grylka-Baeschlin, S, Handra, C, Zaigham, M, Orovou, E, Barata, C, Szlendak, B, Zenzmaier, C, Vik, E, Liepinaitiene, A, Drglin, Z, Arendt, M, Sacks, E, Lazzerini, M, Valente E. P., Mariani I., Bomben A., Morano S., Gemperle M., Otelea M. R., Miani C., Elden H., Sarantaki A., Costa R., Baranowska B., Konig-Bachmann M., Kongslien S., Drandic D., Rozee V., Nespoli A., Abderhalden-Zellweger A., Nanu I., Batram-Zantvoort S., Linden K., Metallinou D., Dias H., Tataj-Puzyna U., D'Costa E., Nedberg I. H., Kurbanovic M., de La Rochebrochard E., Fumagalli S., Grylka-Baeschlin S., Handra C. M., Zaigham M., Orovou E., Barata C., Szlendak B., Zenzmaier C., Vik E. S., Liepinaitiene A., Drglin Z., Arendt M., Sacks E., and Lazzerini M.

Abstract

Background: Health workers' (HWs') perspectives on the quality of maternal and newborn care (QMNC) are not routinely collected. In this cross-sectional study, we aimed to document HWs' perspectives on QMNC around childbirth in 12 World Health Organization (WHO) European countries. Methods: HWs involved in maternal/neonatal care for at least one year between March 2020 and March 2023 answered an online validated WHO standards-based questionnaire collecting 40 quality measures for improving QMNC. A QMNC index (score 0-400) was calculated as a synthetic measure. Results: Data from 4143 respondents were analysed. For 39 out of 40 quality measures, at least 20% of HWs reported a 'need for improvement', with large variations across countries. Effective training on healthy women/newborns management (n = 2748, 66.3%), availability of informed consent job aids (n = 2770, 66.9%), and effective training on women/newborns rights (n = 2714, 65.5%) presented the highest proportion of HWs stating 'need for improvement'. Overall, 64.8% (n = 2684) of respondents declared that HWs' numbers were insufficient for appropriate care (66.3% in Portugal and 86.6% in Poland), and 22.4% described staff censorship (16.3% in Germany and 56.7% in Poland). The reported QMNC index was low in all countries (Poland median (MD) = 210.60, interquartile range (IQR) = 155.71, 273.57; Norway MD = 277.86; IQR = 244.32, 308.30). The 'experience of care' domain presented in eight countries had significantly lower scores than the other domains (P < 0.001). Over time, there was a significant monthly linear decrease in the QMNC index (P < 0.001), lacking correlation with the coronavirus disease 2019 (COVID-19) pandemic trends (P > 0.05). Multivariate analyses confirmed large QMNC variation by country. HWs with <10 years of experience, HWs from public facilities, and midwives rated QMNC with significantly lower scores (P < 0.001). Conclusions: HWs from 12 European countries reported significant g

Published
2024

2. Vulnerable newborn types : analysis of subnational, population‐based birth cohorts for 541 285 live births in 23 countries, 2000-2021

Author

Erchick, D. J., Hazel, E. A., Katz, J., Lee, A. C. C., Diaz, M., Wu, L. S. F., Yoshida, S., Bahl, R., Grandi, C., Labrique, A. B., Rashid, M., Ahmed, S., Roy, A. D., Haque, R., Shaikh, S., Baqui, A. H., Saha, S. K., Khanam, R., Rahman, S., Shapiro, R., Zash, R., Silveira, M. F., Buffarini, R., Kolsteren, Patrick, Lachat, Carl, Huybregts, Lieven, Roberfroid, D., Zeng, L., Zhu, Z., He, J., Qiu, X., Gebreyesus, S. H., Hadush, Kokeb Tesfamariam, Bekele, D., Chan, G., Baye, E., Workneh, F., Asante, K. P., Kaali, E. B., Adu‐Afarwuah, S., Dewey, K. G., Gyaase, S., Wylie, B. J., Kirkwood, B. R., Manu, A., Thulasiraj, R. D., Tielsch, J., Chowdhury, R., Taneja, S., Babu, G. R., Shriyan, P., Ashorn, P., Maleta, K., Ashorn, U., Mangani, C., Acevedo‐Gallegos, S., Rodriguez‐Sibaja, M. J., Khatry, S. K., LeClerq, S. C., Mullany, L. C., Jehan, F., Ilyas, M., Rogerson, S. J., Unger, H. W., Ghosh, R., Musange, S., Ramokolo, V., Zembe‐Mkabile, W., Lazzerini, M., Rishard, M., Wang, D., Fawzi, W. W., Minja, D. T. R., Schmiegelow, C., Masanja, H., Smith, E., Lusingu, J. P. A., Msemo, O. A., Kabole, F. M., Slim, S. N., Keentupthai, P., Mongkolchati, A., Kajubi, R., Kakuru, A., Waiswa, P., Walker, D., Hamer, D. H., Semrau, K. E. A., Chaponda, E. B., Chico, R. M., Banda, B., Musokotwane, K., Manasyan, A., Pry, J. M., Chasekwa, B., Humphrey, J., Black, R. E., Ali, Hasmot, Christian, Parul, Klemm, Rolf D. W., Massie, Alan B., Mitra, Maithili, Mehra, Sucheta, Schulze, Kerry J., Shamim, Abu Ahmed, Sommer, Alfred, Barkat Ullah, MD., West, Keith P., Begum, Nazma, Chowdhury, Nabidul Haque, Shafiqul Islam, Md., Mitra, Dipak Kumar, Quaiyum, Abdul, Diseko, Modiegi, Makhema, Joseph, Cheng, Yue, Guo, Yixin, Yuan, Shanshan, Roro, Meselech, Shikur, Bilal, Goddard, Frederick, Haneuse, Sebastien, Hunegnaw, Bezawit, Berhane, Yemane, Worku, Alemayehu, Kaali, Seyram, Arnold, Charles D., Jack, Darby, Amenga‐Etego, Seeba, Hurt, Lisa, Shannon, Caitlin, Soremekun, Seyi, Bhandari, Nita, Martines, Jose, Mazumder, Sarmila, Ana, Yamuna, Deepa, R, Hallamaa, Lotta, Pyykkö, Juha, Lumbreras‐Marquez, Mario I., Mendoza‐Carrera, Claudia E., Hussain, Atiya, Karim, Muhammad, Kausar, Farzana, Mehmood, Usma, Nadeem, Naila, Nisar, Muhammad Imran, Sajid, Muhammad, Mueller, Ivo, Ome‐Kaius, Maria, Butrick, Elizabeth, Sayinzoga, Felix, Mariani, Ilaria, Urassa, Willy, Theander, Thor, Deloron, Phillippe, Nielsen, Birgitte Bruun, Muhihi, Alfa, Noor, Ramadhani Abdallah, Bygbjerg, Ib, Moeller, Sofie Lykke, Aftab, Fahad, Ali, Said M., Dhingra, Pratibha, Dhingra, Usha, Dutta, Arup, Sazawal, Sunil, Suleiman, Atifa, Mohammed, Mohammed, Deb, Saikat, Kamya, Moses R., Nakalembe, Miriam, Mulowooz, Jude, Santos, Nicole, Biemba, Godfrey, Herlihy, Julie M., Mbewe, Reuben K., Mweena, Fern, Yeboah‐Antwi, Kojo, Bruce, Jane, Chandramohan, Daniel, Prendergast, Andrew, Lawn, Joy E., Blencowe, Hannah, Ohuma, Eric, Okwaraji, Yemi, Yargawa, Judith, Bradley, Ellen, Katz, Joanne, and the Subnational Vulnerable Newborn Prevalence Collaborative Group and Vulnerable Newborn Measurement Core Group, [missing]

Subjects
RISK, small for gestational age, PRETERM, newborn, MIDDLE-INCOME COUNTRIES, MORTALITY, FOR-GESTATIONAL-AGE, Medicine and Health Sciences, preterm birth, INFANTS, WEIGHT, TERM, low birthweight
Abstract

Setting: Subnational, population-based birth cohort studies (n = 45) in 23 low-and middle-income countries (LMICs) spanning 2000–2021. Population: Liveborn infants. Methods: Subnational, population-based studies with high-quality birth outcome data from LMICs were invited to join the Vulnerable Newborn Measurement Collaboration. We defined distinct newborn types using gestational age (preterm [PT], term [T]), birthweight for gestational age using INTERGROWTH-21st standards (small for gestational age [SGA], appropriate for gestational age [AGA] or large for gestational age [LGA]), and birthweight (low birthweight, LBW [

Published
2023

5. Quality of facility-based maternal and newborn care around the time of childbirth during the COVID-19 pandemic: online survey investigating maternal perspectives in 12 countries of the WHO European Region

Author

Antropologia, Filosofia i Treball Social, Universitat Rovira i Virgili, Lazzerini M; Covi B; Mariani I; Drglin Z; Arendt M; Nedberg IH; Elden H; Costa R; Drandi? D; Radeti? J; Otelea MR; Miani C; Brigidi S; Rozée V; Ponikvar BM; Tasch B; Kongslien S; Linden K; Barata C; Kurbanovi? M; Ruži?i? J; Batram-Zantvoort S; Castañeda LM; Rochebrochard EDL; Bohinec A; Vik ES; Zaigham M; Santos T; Wandschneider L; Viver AC; ?erimagi? A; Sacks E; Valente EP; IMAgiNE EURO study group, Antropologia, Filosofia i Treball Social, Universitat Rovira i Virgili, and Lazzerini M; Covi B; Mariani I; Drglin Z; Arendt M; Nedberg IH; Elden H; Costa R; Drandi? D; Radeti? J; Otelea MR; Miani C; Brigidi S; Rozée V; Ponikvar BM; Tasch B; Kongslien S; Linden K; Barata C; Kurbanovi? M; Ruži?i? J; Batram-Zantvoort S; Castañeda LM; Rochebrochard EDL; Bohinec A; Vik ES; Zaigham M; Santos T; Wandschneider L; Viver AC; ?erimagi? A; Sacks E; Valente EP; IMAgiNE EURO study group

Abstract

Background: Multi-country studies assessing the quality of maternal and newborn care (QMNC) during the COVID-19 pandemic, as defined by WHO Standards, are lacking. Methods: Women who gave birth in 12 countries of the WHO European Region from March 1, 2020 - March 15, 2021 answered an online questionnaire, including 40 WHO Standard-based Quality Measures. Findings: 21,027 mothers were included in the analysis. Among those who experienced labour (N=18,063), 41·8% (26·1%- 63·5%) experienced difficulties in accessing antenatal care, 62% (12·6%-99·0%) were not allowed a companion of choice, 31·1% (16·5%-56·9%) received inadequate breastfeeding support, 34·4% (5·2%-64·8%) reported that health workers were not always using protective personal equipment, and 31·8% (17·8%-53·1%) rated the health workers’ number as “insufficient”. Episiotomy was performed in 20·1% (6·1%-66·0%) of spontaneous vaginal births and fundal pressure applied in 41·2% (11·5% -100%) of instrumental vaginal births. In addition, 23·9% women felt they were not treated with dignity (12·8%-59·8%), 12·5% (7·0%-23·4%) suffered abuse, and 2·4% (0·1%-26·2%) made informal payments. Most findings were significantly worse among women with prelabour caesarean birth (N=2,964). Multivariate analyses confirmed significant differences among countries, with Croatia, Romania, Serbia showing significant lower QMNC Indexes and Luxemburg showing a significantly higher QMNC Index than the total sample. Younger women and those with operative births also reported significantly lower QMNC Indexes. Interpretation: Mothers reports revealed large inequities in QMNC across countries of the WHO European Region. Quality improvement initiatives to reduce these inequities and promote evidence-based, patient-centred respectful care for all

Published
2022

6. Individual and country-level variables associated with the medicalization of birth

Author

Miani, Céline, Wandschneider, Lisa, Batram-Zantvoort, Stephanie, Covi, B., Elden, H., Nedberg, I. Hersoug, Drglin, Z., Pumpere, E., Costa, R., and Lazzerini, M.

Subjects
Public Health, Environmental and Occupational Health
Abstract

Introduction According to the World Health Organization, the medicalisation of birth tends “to undermine the woman's own capability to give birth and negatively impacts her childbirth experience”. The COVID-19 pandemic has disrupted maternity care, with potential increase in the medicalisation of birth and in occurrences of disrespectful maternity care. We aim to investigate potential associations between individual and country-level factors and medicalisation of birth in 15 European countries during the COVID-19 pandemic. Methods We collected data through an online, anonymous survey for women who gave birth in 2020-2021. We ran multivariable, multi-level logistic regression models estimating associations between indicators of medicalisation (caesarean section (CS), instrumental vaginal birth (IVB), episiotomy, fundal pressure) and proxy variables related to care culture and contextual factors at the individual and country-level. Results Among 27173 women, 24.4% had a CS, and 8.8% an IVB. Among women with IVB, 41.9% reported receiving fundal pressure. Among women with spontaneous vaginal births, 22.3% had an episiotomy. Less respectful care, as perceived by the women, was associated with higher levels of medicalisation. For example, women who reported having CS, IVB and episiotomy reported not feeling treated with dignity more frequently than women who didn't have those interventions (respectively: OR: 1.37; OR: 1.61; OR: 1.51; all: p < 0.001). Country-level variables contributed to explaining some of the variance between countries. Conclusions We recommend a greater emphasis in health policies on the promotion of respectful and patient-centered care approaches to birth to enhance women's experiences of care, and the development of a European-level indicator to monitor the medicalisation of reproductive care. Speakers/Panellists Emanuelle Pessa Valente WHO Collaborating Centre, Institute for Maternal and Child Health IRCCS, Trieste, Italy

Published
2022
Full Text
View/download PDF

7. Quality of facility-based maternal and newborn care around the time of childbirth during the COVID-19 pandemic: online survey investigating maternal perspectives in 12 countries of the WHO European Region

Author

Lazzerini, M, Covi, B, Mariani, I, Drglin, Z, Arendt, M, Nedberg, IH, Elden, H, Costa, R, Drandić, D, Radetić, J, Otelea, MR, Miani, C, Brigidi, S, Rozée, V, Ponikvar, BM, Tasch, B, Kongslien, S, Linden, K, Barata, C, Kurbanović, M, Ružičić, J, Batram-Zantvoort, S, Castañeda, LM, Rochebrochard, E, Bohinec, A, Vik, ES, Zaigham, M, Santos, T, Wandschneider, L, Viver, AC, Ćerimagić, A, Sacks, E, Valente, EP, IMAgiNE EURO study group, Repositório da Universidade de Lisboa, Veritati - Repositório Institucional da Universidade Católica Portuguesa, and Instituto de Saúde Pública da Universidade do Porto

Subjects
COVID-19, European Region, maternal, newborn, facility, quality of care, questionnaire, respectful maternity care, survey, WHO, EUROPE, BIRTH, Respectful maternity care, Maternal, Article, Internal Medicine, Survey, POST_NATAL_CARE, Questionnaire, Health Policy, Facility, Quality of care, Newborn, Oncology, Public aspects of medicine, RA1-1270, CHILDBIRTH, SAMPLE_SURVEYS
Abstract

Background Multi-country studies assessing the quality of maternal and newborn care (QMNC) during the COVID-19 pandemic, as defined by WHO Standards, are lacking. Methods Women who gave birth in 12 countries of the WHO European Region from March 1, 2020 - March 15, 2021 answered an online questionnaire, including 40 WHO Standard-based Quality Measures. Findings 21,027 mothers were included in the analysis. Among those who experienced labour (N=18,063), 41·8% (26·1%- 63·5%) experienced difficulties in accessing antenatal care, 62% (12·6%-99·0%) were not allowed a companion of choice, 31·1% (16·5%-56·9%) received inadequate breastfeeding support, 34·4% (5·2%-64·8%) reported that health workers were not always using protective personal equipment, and 31·8% (17·8%-53·1%) rated the health workers’ number as “insufficient”. Episiotomy was performed in 20·1% (6·1%-66·0%) of spontaneous vaginal births and fundal pressure applied in 41·2% (11·5% -100%) of instrumental vaginal births. In addition, 23·9% women felt they were not treated with dignity (12·8%-59·8%), 12·5% (7·0%-23·4%) suffered abuse, and 2·4% (0·1%-26·2%) made informal payments. Most findings were significantly worse among women with prelabour caesarean birth (N=2,964). Multivariate analyses confirmed significant differences among countries, with Croatia, Romania, Serbia showing significant lower QMNC Indexes and Luxemburg showing a significantly higher QMNC Index than the total sample. Younger women and those with operative births also reported significantly lower QMNC Indexes. Interpretation Mothers reports revealed large inequities in QMNC across countries of the WHO European Region. Quality improvement initiatives to reduce these inequities and promote evidence-based, patient-centred respectful care for all mothers and newborns during the COVID-19 pandemic and beyond are urgently needed. Funding The study was financially supported by the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy. Study registration ClinicalTrials.gov Identifier: NCT04847336 This research was funded by the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste Italy.

Published
2022

8. Children and coronavirus: The necessary search for a balance between the alleged risks and documented collateral damage [Bambini e coronavirus: La doverosa ricerca di un equilibrio tra i presunti rischi e i documentati danni collaterali]

Author

Tamburlini, G, Marchetti, F, Bertino, E, Bestetti, G, Biasucci, G, Biondi, A, Bonati, M, Brunelli, A, Corsello, G, Esposito, S, Fagioli, F, Farina, D, Gagliardi, L, Gangemi, M, Greco, L, Lanari, M, Lazzerini, M, Maggiore, G, Martelossi, S, Ramenghi, U, Piga, A, Selicorni, A, Spada, M, Ventura, A, Vicari, S, Zampino, G, Zanetto, F, Tamburlini G., Marchetti F., Bertino E., Bestetti G., Biasucci G., Biondi A., Bonati M., Brunelli A., Corsello G., Esposito S., Fagioli F., Farina D., Gagliardi L., Gangemi M., Greco L., Lanari M., Lazzerini M., Maggiore G., Martelossi S., Ramenghi U., Piga A., Selicorni A., Spada M., Ventura A., Vicari S., Zampino G., Zanetto F., Tamburlini, G, Marchetti, F, Bertino, E, Bestetti, G, Biasucci, G, Biondi, A, Bonati, M, Brunelli, A, Corsello, G, Esposito, S, Fagioli, F, Farina, D, Gagliardi, L, Gangemi, M, Greco, L, Lanari, M, Lazzerini, M, Maggiore, G, Martelossi, S, Ramenghi, U, Piga, A, Selicorni, A, Spada, M, Ventura, A, Vicari, S, Zampino, G, Zanetto, F, Tamburlini G., Marchetti F., Bertino E., Bestetti G., Biasucci G., Biondi A., Bonati M., Brunelli A., Corsello G., Esposito S., Fagioli F., Farina D., Gagliardi L., Gangemi M., Greco L., Lanari M., Lazzerini M., Maggiore G., Martelossi S., Ramenghi U., Piga A., Selicorni A., Spada M., Ventura A., Vicari S., Zampino G., and Zanetto F.

Published
2020

10. Multicentre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as at 10 April 2020

Author

Garazzino, S., Montagnani, C., Dona, D., Meini, A., Felici, E., Vergine, G., Bernardi, S., Giacchero, R., Vecchio, A. L., Marchisio, P., Nicolini, G., Pierantoni, L., Rabbone, I., Banderali, G., Denina, M., Venturini, E., Krzysztofiak, A., Badolato, R., Bianchini, S., Galli, L., Villani, A., Castelli-Gattinara, G., Salvini, F., Abbagnato, L., Castagnola, E., Dodi, I., Ghitti, C., Lippi, P., Agostiniani, R., Cherubini, S., Valentini, P., Gianino, P., Vaccaro, A., Manzoni, P., Verna, P., Comberiati, P., Di Filippo, P., Gallia, P., Battezzati, G., Fiore, L., Dalmazzo, C., Tappi, E., Lazzerini, M., Tovo, P. -A., Scolfaro, C., Pruccoli, G., Ramenghi, U., Giaquinto, C., da Dalt, L., Tornese, G., Berlese, P., Plebani, A., Manno, E. C., Santilli, V., Lancella, L., Cursi, L., Campana, A., Bozzola, E., Bosis, S., Lanari, M., Pecoraro, C., Del Barba, P., Nicastro, E., Esposito, S., Zuccotti, G. V., Corsello, G., Cardinale, F., Tocco, A. M., Ballardini, G., Agostoni, C., Chiappini, E., Indolfi, G., Anna, B., Cazzato, S., Zavarise, G., Pignata, C., Marchetti, F., Garazzino S., Montagnani C., Dona D., Meini A., Felici E., Vergine G., Bernardi S., Giacchero R., Vecchio A.L., Marchisio P., Nicolini G., Pierantoni L., Rabbone I., Banderali G., Denina M., Venturini E., Krzysztofiak A., Badolato R., Bianchini S., Galli L., Villani A., Castelli-Gattinara G., Salvini F., Abbagnato L., Castagnola E., Dodi I., Ghitti C., Lippi P., Agostiniani R., Cherubini S., Valentini P., Gianino P., Vaccaro A., Manzoni P., Verna P., Comberiati P., Di Filippo P., Gallia P., Battezzati G., Fiore L., Dalmazzo C., Tappi E., Lazzerini M., Tovo P.-A., Scolfaro C., Pruccoli G., Ramenghi U., Giaquinto C., da Dalt L., Tornese G., Berlese P., Plebani A., Manno E.C., Santilli V., Lancella L., Cursi L., Campana A., Bozzola E., Bosis S., Lanari M., Pecoraro C., Del Barba P., Nicastro E., Esposito S., Zuccotti G.V., Corsello G., Cardinale F., Tocco A.M., Ballardini G., Agostoni C., Chiappini E., Indolfi G., Anna B., Cazzato S., Zavarise G., Pignata C., Marchetti F., Garazzino, S., Montagnani, C., Dona, D., Meini, A., Felici, E., Vergine, G., Bernardi, S., Giacchero, R., Vecchio, A. L., Marchisio, P., Nicolini, G., Pierantoni, L., Rabbone, I., Banderali, G., Denina, M., Venturini, E., Krzysztofiak, A., Badolato, R., Bianchini, S., Galli, L., Villani, A., Castelli-Gattinara, G, Tornese, G, Filippo Salvini, Laura Abbagnato, Elio Castagnola, Icilio Dodi, Cesare Ghitti, Paola Lippi, Rino Agostiniani, Simonetta Cherubini, Piero Valentini, Paola Gianino, Angelina Vaccaro, Paolo Manzoni, Paola Verna, Pasquale Comberiati, Paola Di Filippo, Paola Gallia, Gianna Battezzati, Ludovica Fiore, Cristina Dalmazzo, Eleonora Tappi, Marta Lazzerini, PierAngelo Tovo, Carlo Scolfaro, Giulia Pruccoli, Ugo Ramenghi, Carlo Giaquinto, Liviana Da Dalt, Gianluca Tornese, Paola Berlese, Alessandro Plebani, Emma Concetta Manno, Veronica Santilli, Laura Lancella, Laura Cursi, Andrea Campana, Elena Bozzola, Samantha Bosis, Marcello Lanari, Carmine Pecoraro, Paolo Del Barba, Emanuele Nicastro, Silvia Garazzino, Carlotta Montagnani, Daniele Donà, Antonella Meini, Enrico Felici, Gianluca Vergine, Stefania Bernardi, Roberta Giacchero, Andrea Lo Vecchio, Paola Marchisio, Giangiacomo Nicolini, Luca Pierantoni, Ivana Rabbone, Giuseppe Banderali, Marco Denina, Elisabetta Venturini, Andrzej Krzysztofiak , Raffaele Badolato, Sonia Bianchini, Luisa Galli, Alberto Villani , Guido Castelli-Gattinara, Susanna Esposito, Gian Vincenzo Zuccotti, Giovanni Corsello, Fabio Cardinale, Anna Maria Tocco, Giuseppina Ballardini, Carlo Agostoni, Elena Chiappini, Giuseppe Indolfi, Bussolini Anna, Salvatore Cazzato, Giorgio Zavarise, Claudio Pignata, Federico Marchetti, Lo Vecchio, A., and Castelli-Gattinara, G.

Subjects
Male, Pediatrics, Epidemiology, Protease Inhibitor, Comorbidity, medicine.disease_cause, Clinical Laboratory Technique, Severe Acute Respiratory Syndrome, Disease Outbreaks, Feces, 0302 clinical medicine, Settore MED/38 - Pediatria Generale E Specialistica, COVID-19 Testing, Retrospective Studie, Pandemic, 030212 general & internal medicine, Viral, Child, Coronavirus, Pediatric, Disease Outbreak, Coinfection, Hospitals, Pediatric, Settore MED/38, Hospitals, Diarrhea, Treatment Outcome, SARS-CoV-2 infection, children, covid-19, hydroxychloroquine, pneumonia, Adolescent, Antiviral Agents, Betacoronavirus, COVID-19, Child, Preschool, Chronic Disease, Clinical Laboratory Techniques, Coronavirus Infections, Female, Fever, Humans, Immunocompromised Host, Infant, Infant, Newborn, Italy, Noninvasive Ventilation, Pandemics, Pneumonia, Viral, Protease Inhibitors, Retrospective Studies, SARS-CoV-2, medicine.symptom, Rapid Communication, Human, medicine.medical_specialty, Coronaviru, 03 medical and health sciences, 030225 pediatrics, Virology, Intensive care, medicine, Preschool, Antiviral Agent, Betacoronaviru, business.industry, Coronavirus Infection, Public Health, Environmental and Occupational Health, Retrospective cohort study, medicine.disease, Newborn, Pneumonia, Fece, business
Abstract

Data on features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children and adolescents are scarce. We report preliminary results of an Italian multicentre study comprising 168 laboratory-confirmed paediatric cases (median: 2.3 years, range: 1 day–17.7 years, 55.9% males), of which 67.9% were hospitalised and 19.6% had comorbidities. Fever was the most common symptom, gastrointestinal manifestations were frequent; two children required intensive care, five had seizures, 49 received experimental treatments and all recovered.

Published
2020

11. Characteristics and risk factors for SARS-CoV-2 in children tested in the early phase of the pandemic: a cross-sectional study, Italy, 23 February to 24 May 2020

Author

Lazzerini, M., Sforzi, I., Trapani, S., Biban, P., Silvagni, D., Villa, G., Tibaldi, J., Bertacca, L., Felici, E., Perricone, G., Parrino, R., Gioe, C., Lega, S., Conte, Fabrizio Paolo Massimo, Marchetti, Fabio, Magista, A., Berlese, P., Martelossi, S., Vaienti, F., Valletta, E., Mauro, Michele, Dall'Amico, R., Fasoli, S., Gatto, Antonio, Chiaretti, Antonio, Dragovic, D., Pascolo, P., Pilotto, C., Liguoro, I., Miorin, E., Saretta, F., Trobia, G. L., Di Stefano, A., Orlandi, Armando, Cardinale, F., Lubrano, R., Testa, A., Binotti, M., Moressa, V., Barbi, E., Armocida, B., Mariani, I., Conte M., Marchetti F., Mauro M., Gatto A., Chiaretti A. (ORCID:0000-0002-9971-1640), Orlandi A. (ORCID:0000-0001-5253-4678), Lazzerini, M., Sforzi, I., Trapani, S., Biban, P., Silvagni, D., Villa, G., Tibaldi, J., Bertacca, L., Felici, E., Perricone, G., Parrino, R., Gioe, C., Lega, S., Conte, Fabrizio Paolo Massimo, Marchetti, Fabio, Magista, A., Berlese, P., Martelossi, S., Vaienti, F., Valletta, E., Mauro, Michele, Dall'Amico, R., Fasoli, S., Gatto, Antonio, Chiaretti, Antonio, Dragovic, D., Pascolo, P., Pilotto, C., Liguoro, I., Miorin, E., Saretta, F., Trobia, G. L., Di Stefano, A., Orlandi, Armando, Cardinale, F., Lubrano, R., Testa, A., Binotti, M., Moressa, V., Barbi, E., Armocida, B., Mariani, I., Conte M., Marchetti F., Mauro M., Gatto A., Chiaretti A. (ORCID:0000-0002-9971-1640), and Orlandi A. (ORCID:0000-0001-5253-4678)

Abstract

BackgroundVery few studies describe factors associated with COVID-19 diagnosis in children.AimWe here describe characteristics and risk factors for COVID-19 diagnosis in children tested in 20 paediatric centres across Italy.MethodsWe included cases aged 0-18 years tested between 23 February and 24 May 2020. Our primary analysis focused on children tested because of symptoms/signs suggestive of COVID-19.ResultsAmong 2,494 children tested, 2,148 (86.1%) had symptoms suggestive of COVID-19. Clinical presentation of confirmed COVID-19 cases included besides fever (82.4%) and respiratory signs or symptoms (60.4%) also gastrointestinal (18.2%), neurological (18.9%), cutaneous (3.8%) and other unspecific influenza-like presentations (17.8%). In multivariate analysis, factors significantly associated with SARS-CoV-2 positivity were: exposure history (adjusted odds ratio (AOR): 39.83; 95% confidence interval (CI): 17.52-90.55; p < 0.0001), cardiac disease (AOR: 3.10; 95% CI: 1.19-5.02; p < 0.0001), fever (AOR: 3.05%; 95% CI: 1.67-5.58; p = 0.0003) and anosmia/ageusia (AOR: 4.08; 95% CI: 1.69-9.84; p = 0.002). Among 190 (7.6%) children positive for SARS-CoV-2, only four (2.1%) required respiratory support and two (1.1%) were admitted to intensive care; all recovered.ConclusionRecommendations for SARS-CoV-2 testing in children should consider the evidence of broader clinical features. Exposure history, fever and anosmia/ageusia are strong risk factors in children for positive SARS-CoV-2 testing, while other symptoms did not help discriminate positive from negative individuals. This study confirms that COVID-19 was a mild disease in the general paediatric population in Italy. Further studies are needed to understand risk, clinical spectrum and outcomes of COVID-19 in children with pre-existing conditions.

Published
2021

13. Children and coronavirus: The necessary search for a balance between the alleged risks and documented collateral damage

Author

Tamburlini, G., Marchetti, F., Bertino, E., Bestetti, G., Biasucci, G., Biondi, A., Bonati, M., Brunelli, A., Corsello, G., Esposito, S., Fagioli, F., Farina, D., Gagliardi, L., Gangemi, M., Greco, L., Lanari, M., Lazzerini, M., Maggiore, G., Martelossi, S., Ramenghi, U., Piga, A., Selicorni, A., Spada, M., Ventura, A., Vicari, S., Zampino, G., and Zanetto, F.

Published
2020

17. Thalidomide-induced peripheral neuropathy in children with inflammatory bowel disease

Author

Bramuzzo, M., Stocco, G., Montico, M., Arrigo, S., Calvi, A., Lanteri, P., Costa, S., Pellegrino, S., Magazzù, G., Berp, J., Ghione, S., Lionetti, P., Zuin, G., Fontana, M., Di Chio, T., Maggiore, Giuseppe, Lazzerini, M., Lucafò, M., Udina, C., Pellegrin, Mc, Chicco, A., Carrozzi, M., Decorti, G., Ventura, A., and Martellossi, S.

Subjects
NO
Published
2017

19. Child Health in the European Union

Author

Cattaneo A, Cogoy L, Macaluso A, Tamburlini G, Bavcar A, I, Bruno, Carletti C, Lazzerini M, Monasta L, Montico M, P, Pani, Ronfani L, Alvarez A, Cerniauskaite M, Leonardi M, Meucci P, Merletti F, Pisani P, P, Pierpaolo Mastroiacovo, Barbone F, Deroma L, F, Valent, Averna R, F, Freda, Penge R, Bonati M, Clavenna A, F, Severino, and N, Spencer

Published
2012
Full Text
View/download PDF

20. A multicenter study on drug safety in children [Studio multicentrico sulla sicurezza dei farmaci in pediatria]

Author

Menniti-Ippolito, F., Da Cas, R., Bolli, M., Annalisa Capuano, Saglioca, L., Traversa, G., Messi, G., Marchetti, F., Lazzerini, M., Rovere, F., Tripaldi, E., Da Dalt, L., Bressan, E., Capretta, A., Falcon, E., Intini, F., Mongillo, B., Morando, C., Di Pietro, P., Rossi, R., Barbino, P., Bianchi, C., Renna, S., Dorozzi, N., Ceccheti, C., Iori, V., Lauri, M., Rauchi, U., Reale, A., Vetrano, F., Saggiamo, G., Giuliano, F. M., and Tipo, V.

Subjects
Hosptial admissions, Adverse drug reactions, Case-control study, Children
Published
2007

21. Low-dose chest computed tomography for quantitative and visual anatomical analysis in patients with acute respiratory distress syndrome

Author

Chiumello, D, Langer, T, Vecchi, V, Luoni, S, Colombo, A, Brioni, M, Froio, S, Cigada, I, Coppola, S, Protti, A, Lazzerini, M, Gattinoni, L, Chiumello, D, Langer, T, Vecchi, V, Luoni, S, Colombo, A, Brioni, M, Froio, S, Cigada, I, Coppola, S, Protti, A, Lazzerini, M, and Gattinoni, L

Abstract

Chest computed tomography (CT) is a fundamental tool for the characterization of acute respiratory distress syndrome (ARDS). Its frequent use is, however, hindered by the associated radiation exposure. The aim of the present study was to evaluate, in patients with ARDS, the accuracy of quantitative and visual anatomical lung analysis performed on low-dose CT. We hypothesized that low-dose CT would provide accurate quantitative and visual anatomical results. Chest CT was performed in 45 ARDS patients in static conditions at set airway pressures of 45 and 15 or 45 and 5 cmH(2)O. During each pause, two consecutive scans were obtained at two different tube current-time products (mAs). In 24 patients 110 mAs was coupled with 60 mAs; in 21 patients 110 was coupled with 30 mAs. All other CT parameters were kept unaltered. Quantitative and visual anatomical results obtained at different mAs were compared via Bland-Altman analysis. Good agreements were observed between 110 and 60 mAs and between 110 and 30 mAs both for quantitative and visual anatomical results (all biases below 1.5 %). Estimated mean effective dose at 110, 60, and 30 mAs corresponded to 5.3 +/- A 1.6, 2.8 +/- A 0.8, and 1.4 +/- A 0.3 mSv, respectively. In patients with ARDS a reduction of mAs up to 30 (70 % effective dose reduction) can be achieved without significant effect on quantitative and visual anatomical results. Low-dose chest CT, with related quantitative and visual anatomical analysis, could be a valuable tool to characterize and potentially monitor lung disease in patients with ARDS

Published
2014

22. Lung stress and strain during mechanical ventilation : any safe threshold?

Author

Protti, A, Cressoni Mainoni, M, Santini, A, Langer, T, Mietto, C, Febres, D, Chierichetti, M, Coppola, S, Conte, G, Gatti, S, Leopardi, O, Masson, S, Lombardi, L, Lazzerini, M, Rampoldi, E, Cadringher, P, Gattinoni, L, Cressoni Mainoni, MT, Protti, A, Cressoni Mainoni, M, Santini, A, Langer, T, Mietto, C, Febres, D, Chierichetti, M, Coppola, S, Conte, G, Gatti, S, Leopardi, O, Masson, S, Lombardi, L, Lazzerini, M, Rampoldi, E, Cadringher, P, Gattinoni, L, and Cressoni Mainoni, MT

Abstract

RATIONALE: Unphysiologic strain (the ratio between tidal volume and functional residual capacity) and stress (the transpulmonary pressure) can cause ventilator-induced lung damage. OBJECTIVES: To identify a strain-stress threshold (if any) above which ventilator-induced lung damage can occur. METHODS: Twenty-nine healthy pigs were mechanically ventilated for 54 hours with a tidal volume producing a strain between 0.45 and 3.30. Ventilator-induced lung damage was defined as net increase in lung weight. MEASUREMENTS AND MAIN RESULTS: Initial lung weight and functional residual capacity were measured with computed tomography. Final lung weight was measured using a balance. After setting tidal volume, data collection included respiratory system mechanics, gas exchange and hemodynamics (every 6 h); cytokine levels in serum (every 12 h) and bronchoalveolar lavage fluid (end of the experiment); and blood laboratory examination (start and end of the experiment). Two clusters of animals could be clearly identified: animals that increased their lung weight (n = 14) and those that did not (n = 15). Tidal volume was 38 ± 9 ml/kg in the former and 22 ± 8 ml/kg in the latter group, corresponding to a strain of 2.16 ± 0.58 and 1.29 ± 0.57 and a stress of 13 ± 5 and 8 ± 3 cm H(2)O, respectively. Lung weight gain was associated with deterioration in respiratory system mechanics, gas exchange, and hemodynamics, pulmonary and systemic inflammation and multiple organ dysfunction. CONCLUSIONS: In healthy pigs, ventilator-induced lung damage develops only when a strain greater than 1.5-2 is reached or overcome. Because of differences in intrinsic lung properties, caution is warranted in translating these findings to humans

Published
2011

23. CO10 THALIDOMIDE AFTER INFLIXIMAB FAILURE IN CHILDREN AND YOUNG ADULTS WITH CROHN'S DISEASE AND ULCERATIVE COLITIS

Author

Bramuzzo, M., primary, Lazzerini, M., additional, Martelossi, S., additional, Pellegrin, M.C., additional, Maschio, M., additional, Marchetti, F., additional, Magazzù, G., additional, Pellegrino, S., additional, Ruggeri, C., additional, Scibilia, G., additional, Barabino, A., additional, Calvi, A., additional, Arrigo, S., additional, Fontana, M., additional, Lionetti, P., additional, Mangiantini, F., additional, Lorusso, M., additional, Palla, G., additional, Maggiore, G., additional, Villanacci, V., additional, Bartoli, F., additional, Decorti, G., additional, De Iudicibus, S., additional, Monasta, L., additional, Montico, M., additional, Ronfani, L., additional, Paparazzo, R., additional, Lora, A., additional, and Ventura, A., additional

Published
2012
Full Text
View/download PDF

28. P028 THALIDOMIDE FOR TREATING REFRACTORY CROHN'S DISEASE AND ULCERATIVE COLITIS IN CHILDREN: RANDOMIZED CONTROLLED TRIAL (PRELIMINARY RESULTS)

Author

Lazzerini, M., primary, Martelossi, S., additional, Maschio, M., additional, Marchetti, F., additional, Bramuzzo, M., additional, Magazzù, G., additional, Scibilia, G., additional, Barabino, A., additional, Calvi, A., additional, Fontana, M., additional, Lionetti, P., additional, Mangiantini, F., additional, Lorusso, M., additional, Palla, G., additional, Maggiore, G., additional, Villanacci, V., additional, Bartoli, F., additional, Decorti, G., additional, De Iudicibus, S., additional, Montico, M., additional, Paparazzo, R., additional, and Ventura, A., additional

Published
2009
Full Text
View/download PDF

39. Smartphones for Mobile Teleradiology in Paediatric Imaging: Evaluation of Diagnostic Accuracy.

Author

Zennaro, F., Bava, M., Casalino, A., Guastalla, P. P., Ronfani, L., and Lazzerini, M.

Subjects
SMARTPHONES, MOBILE communication systems, TELERADIOLOGY, PEDIATRICS, MAGNETIC resonance imaging
Abstract

Teleradiology is a useful practice to provide remote consultation from specialists or senior staff, when no staff is available "on-site", and a quick consultation or a second opinion is necessary. Recently smartphones with high quality display have been marketed. The aim of our study was to determine if these devices could be used for paediatric radiologic remote consultation without loss of diagnostic information. Ninety-three paediatric exams were evaluated. CT and MRI examinations were randomly chosen among performed exams and sent to two different smartphones (Apple iPhone and Nexus One -Android OS-) using a VPN encrypted connection. Two independent radiologists evaluated the images prospectively. Results were collected in a database and compared with the gold standard result (PACS system, EBIT Aet DICOMed Review v.4.1, and monitors officially certified for radiologic interpretation). Concordance between diagnostic interpretation using smartphones and the golden standard was 97.52%. Values of specificity and sensitivity were respectively 100% and 96.3%, with a PPV of 100% and a NPV of 93.0%. Missing findings were only minor ones, while the overall diagnostic interpretation was essentially the same. These preliminary results show that diagnostic accuracy of radiologic paediatric interpretation using smartphones is overall acceptable. Although such system is not suitable for long consultation sessions, they can be used for quick remote consultation on single cases. [ABSTRACT FROM AUTHOR]

Published
2013

40. Lung stress and strain during mechanical ventilation: any safe threshold?

Author

Protti A, Cressoni M, Santini A, Langer T, Mietto C, Febres D, Chierichetti M, Coppola S, Conte G, Gatti S, Leopardi O, Masson S, Lombardi L, Lazzerini M, Rampoldi E, Cadringher P, Gattinoni L, Protti, Alessandro, Cressoni, Massimo, and Santini, Alessandro

Abstract

Rationale: Unphysiologic strain (the ratio between tidal volume and functional residual capacity) and stress (the transpulmonary pressure) can cause ventilator-induced lung damage. Objectives: To identify a strain-stress threshold (if any) above which ventilator-induced lung damage can occur. Methods: Twenty-nine healthy pigs were mechanically ventilated for 54 hours with a tidal volume producing a strain between 0.45 and 3.30. Ventilator-induced lung damage was defined as net increase in lung weight. Measurements and Main Results: Initial lung weight and functional residual capacity were measured with computed tomography. Final lung weight was measured using a balance. After setting tidal volume, data collection included respiratory system mechanics, gas exchange and hemodynamics (every 6 h); cytokine levels in serum (every 12 h) and bronchoalveolar lavage fluid (end of the experiment); and blood laboratory examination (start and end of the experiment). Two clusters of animals could be clearly identified: animals that increased their lung weight (n = 14) and those that did not (n = 15). Tidal volume was 38 ± 9 ml/kg in the former and 22 ± 8 ml/kg in the latter group, corresponding to a strain of 2.16 ± 0.58 and 1.29 ± 0.57 and a stress of 13 ± 5 and 8 ± 3 cm H(2)O, respectively. Lung weight gain was associated with deterioration in respiratory system mechanics, gas exchange, and hemodynamics, pulmonary and systemic inflammation and multiple organ dysfunction. Conclusions: In healthy pigs, ventilator-induced lung damage develops only when a strain greater than 1.5-2 is reached or overcome. Because of differences in intrinsic lung properties, caution is warranted in translating these findings to humans. [ABSTRACT FROM AUTHOR]

Published
2011
Full Text
View/download PDF

46. A multicenter study on drug safety in children,Studio multicentrico sulla sicurezza dei farmaci in pediatria

Author

Menniti-Ippolito, F., Da Cas, R., Bolli, M., Capuano, A., Saglioca, L., Traversa, G., Messi, G., Federico Marchetti, Lazzerini, M., Rovere, F., Tripaldi, E., Da Dalt, L., Bressan, E., Capretta, A., Falcon, E., Intini, F., Mongillo, B., Morando, C., Di Pietro, P., Rossi, R., Barbino, P., Bianchi, C., Renna, S., Dorozzi, N., Ceccheti, C., Iori, V., Lauri, M., Rauchi, U., Reale, A., Vetrano, F., Saggiamo, G., Giuliano, F. M., and Tipo, V.

49. Children and coronavirus: The necessary search for a balance between the alleged risks and documented collateral damage,Bambini e coronavirus: La doverosa ricerca di un equilibrio tra i presunti rischi e i documentati danni collaterali

Author

Tamburlini, G., Marchetti, F., Bertino, E., Bestetti, G., Biasucci, G., Biondi, A., Bonati, M., Brunelli, A., Giovanni CORSELLO, Esposito, S., Fagioli, F., Farina, D., Gagliardi, L., Gangemi, M., Greco, L., Lanari, M., Lazzerini, M., Maggiore, G., Martelossi, S., Ramenghi, U., Piga, A., Selicorni, A., Spada, M., Ventura, A., Vicari, S., Zampino, G., and Zanetto, F.

Catalog

Books, media, physical & digital resources
See catalog results