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Studies conducted in rodents indicate a crucial role of the opioid circuit in mediating objective hedonic reactions to primary rewards. However, it remains unclear whether opioid transmission is also essential to experience pleasure with more abstract rewards, such as music. We addressed this question using a double-blind within-subject pharmacological design in which opioid levels were up- and downregulated by administering an opioid agonist (oxycodone) and antagonist (naltrexone), respectively, before healthy participants (n = 21) listened to music. Participants also performed a monetary incentive delay (MID) task to control for the effectiveness of the treatment and the specificity of the effects. Our results revealed that the pharmacological intervention did not modulate subjective reports of pleasure, nor the occurrence of chills. On the contrary, psychophysiological (objective) measures of emotional arousal, such as skin conductance responses (SCRs), were bidirectionally modulated in both the music and MID tasks. This modulation specifically occurred during reward consumption, with greater pleasure-related SCR following oxycodone than naltrexone. These findings indicate that opioid transmission does not modulate subjective evaluations but rather affects objective reward-related psychophysiological responses. These findings raise new caveats about the role of the opioidergic system in the modulation of pleasure for more abstract or cognitive forms of rewarding experiences, such as music.

Music is one of the most pleasurable human experiences. However, the determinants of the variation in individual sensitivity to musical reward are not yet fully unraveled. Empathy has been identified as a determinant of musical affect, including consciously experiencing pleasure from listening to sad music. Additionally, higher musical expertise may enhance pleasurable responses to music, whereas aging decreases individual sensitivity to musical pleasure. We conducted a study to investigate the contribution of empathy and musical abilities on musical pleasure, measured by Interpersonal Reactivity Index, Musical Ear Test, and Barcelona Musical Reward Questionnaire, respectively. To this purpose, we performed a developmental comparison between 48 children (9–11 years old) and 42 adults (18–32 years old). Our findings suggest that individual sensitivity to musical reward is positively correlated with empathy trait in both adults and children, but not with musical abilities. However, when inserted in a regression model including empathy, musical abilities are also predictive of musical reward, but only among adults. These results show that empathy plays a crucial role in determining the individual sensitivity to music reward, whereas musical abilities are less influential. More broadly, this study contributes to shed light on the determinants of the emotional responses to music affect.

Spontaneous sensations (SPS) are bodily sensations that can be perceived even in the absence of any external trigger and are related to self-referential and self-awareness processes. In this study, we investigated whether music, and in particular its emotional arousal dimension, could act as an external stimulus with the ability to modulate SPS. Thirty-two volunteers engaged in an SPS task (focusing on their hands) after having been exposed to high-arousing and low-arousing music. Results showed that after listening to low-arousing, relaxing music (compared to high-arousing, exciting music), participants perceived SPS more intensely, reported more numerous deep interoceptive sensations, and were more confident in specifying the location of these SPS, while their spatial characteristics decreased. These results suggest that relaxing music promoted increased perception by focusing attention on small areas of the hand. By showing for the first time that music can be used as an effective stimulus for modulating SPS, these findings suggest that, by promoting self-awareness processes, the relaxing nature of music can significantly increase the representation of the self.

Music listening provides one of the most significant abstract rewards for humans because hearing music activates the dopaminergic mesolimbic system. Given the strong link between reward, dopamine, and memory, we aimed here to investigate the hypothesis that dopamine-dependent musical reward can drive memory improvements. Twenty-nine healthy participants of both sexes provided reward ratings of unfamiliar musical excerpts that had to be remembered following a consolidation period under three separate conditions: after the ingestion of a dopaminergic antagonist, a dopaminergic precursor, or a placebo. Linear mixed modeling of the intervention data showed that the effect of reward on memory-i.e., the greater the reward experienced while listening to the musical excerpts, the better the memory recollection performance-was modulated by both dopaminergic signaling and individual differences in reward processing. Greater pleasure was consistently associated with better memory outcomes in participants with high sensitivity to musical reward, but this effect was lost when dopaminergic signaling was disrupted in participants with average or low musical hedonia. Our work highlights the flexibility of the human dopaminergic system, which can enhance memory formation not only through explicit and/or primary reinforcers but also via abstract and aesthetic rewards such as music.

Music, thanks to its strong evocative power, is considered a powerful mnemonic tool for both normal and clinical populations. However, the mechanisms underpinning the music-driven benefits on memory remain unclear. In memory research, reward dopaminergic signals have been highlighted as a major modulator of memory traces consolidation. Over the last years, via behavioral and pharmacological approaches, we have investigated the hypothesis that dopaminergic-dependent musical pleasure is a crucial mechanism underpinning music-driven memory benefits. Our results show that the pleasure felt during music listening, modulated by both the dopaminergic transmission and participants' sensitivity to music reward, can increase episodic memory performance for the music itself as well as for nonmusical-associated information. In this commentary paper, we aim to review the main findings obtained from three different studies, in order to discuss current advances and future directions in this research area.

During the past decade, research in cognitive neuroscience has tried to understand how the organized acoustic information we call music is decoded in the brain as pleasant and rewarding stimulus. In this chapter, the authors retrace part of this intriguing journey: from the first positron emission tomography study revealing the association between the mesolimbic system and musical pleasure to the recent pharmacological interventions showing that dopamine causally mediates the subjectively rewarding experience elicited by music. The dopamine-dependent hedonic and motivational responses to music may depend on the modulations of several neural mechanisms related not only to emotion, but also to attention and memory. Musical reward arises therefore as a complex set of processes which constitute a special access key to the study of human cognition.

Although the cerebellum has long been believed to be involved uniquely in sensorimotor processes, recent research works pointed to its participation in a wide range of cognitive predictive functions. Here, we review the available evidence supporting a generalized role of the cerebellum in predictive computation. We then discuss the anatomo-physiological properties that make the cerebellum the ideal hub of the predictive brain. We further argue that cerebellar involvement in cognition may follow a continuous gradient, with higher cerebellar activity occurring for tasks relying more on predictive processes, and outline the empirical scenarios to probe this hypothesis.

Understanding how the brain translates a structured sequence of sounds, such as music, into a pleasant and rewarding experience is a fascinating question which may be crucial to better understand the processing of abstract rewards in humans. Previous neuroimaging findings point to a challenging role of the dopaminergic system in music-evoked pleasure. However, there is a lack of direct evidence showing that dopamine function is causally related to the pleasure we experience from music. We addressed this problem through a double blind within-subject pharmacological design in which we directly manipulated dopaminergic synaptic availability while healthy participants (n = 27) were engaged in music listening. We orally administrated to each participant a dopamine precursor (levodopa), a dopamine antagonist (risperidone), and a placebo (lactose) in three different sessions. We demonstrate that levodopa and risperidone led to opposite effects in measures of musical pleasure and motivation: while the dopamine precursor levodopa, compared with placebo, increased the hedonic experience and music-related motivational responses, risperidone led to a reduction of both. This study shows a causal role of dopamine in musical pleasure and indicates that dopaminergic transmission might play different or additive roles than the ones postulated in affective processing so far, particularly in abstract cognitive activities.

The COVID-19 pandemic has deeply affected mental health. We assessed which of many leisure activities had positive psychological effects, with particular attention to music, which has been reported anecdotally to be important. Questionnaire data from over a thousand individuals primarily from Italy, Spain, and the USA during spring 2020 show that people picked music most often as the best activity to cope with psychological distress. Hours of engagement in music and food-related activities during the pandemic were associated with decreased depression symptoms. The benefits of music were mediated by individual differences in sensitivity to reward, whereas the positive effects of food-related activities were related to emotion regulation. Our results demonstrate that music is an important means of improving well-being, and suggest that the underlying mechanism is related to reward, consistent with neuroscience findings. Our data have practical significance in pointing to effective strategies to cope with mental health issues.

Music listening is one of the most pleasurable activities in our life. As a rewarding stimulus, pleasant music could induce long-term memory improvements for the items encoded in close temporal proximity. In the present study, we behaviourally investigated (1) whether musical pleasure and musical hedonia enhance verbal episodic memory, and (2) whether such enhancement takes place even when the pleasant stimulus is not present during the encoding. Participants (N = 100) were asked to encode words presented in different auditory contexts (highly and lowly pleasant classical music, and control white noise), played before and during (N = 49), or only before (N = 51) the encoding. The Barcelona Music Reward Questionnaire was used to measure participants’ sensitivity to musical reward. 24 h later, participants’ verbal episodic memory was tested (old/new recognition and remember/know paradigm). Results revealed that participants with a high musical reward sensitivity present an increased recollection performance, especially for words encoded in a highly pleasant musical context. Furthermore, this effect persists even when the auditory stimulus is not concurrently present during the encoding of target items. Taken together, these findings suggest that musical pleasure might constitute a helpful encoding context able to drive memory improvements via reward mechanisms.

Previously, we provided causal evidence for a dopamine-dependent effect of intrinsic reward on memory during self-regulated learning (Ripollés et al., 2016; Ripollés et al., 2018). Here, we further investigated the dopamine-dependent link between reward and memory by focusing on one of the most iconic abstract rewards in humans: music. Twenty-nine healthy participants listened to unfamiliar excerpts—which had to be remembered following a consolidation period—after the intake of a dopaminergic antagonist, a dopaminergic precursor, and a placebo across three separated sessions. The intervention modulated the pleasantness experienced during music-listening and memory recognition of the presented songs (i.e., lower with the antagonist, higher with the precursor) in individuals with higher sensitivity to musical reward. Our work highlights the flexibility of the human dopaminergic system, which is able to enhance memory formation not only through explicit and/or primary reinforcers but also via intrinsic, abstract, or aesthetic rewards of different natures.

Le cerveau humain a la capacite unique de modifier sa structure et sa fonction tout au long de la vie, un phenomene appele la plasticite cerebrale. La musique est un stimulus riche et complexe capable de stimuler tout le cerveau, induisant ainsi des changements neuronaux importants. Quelle est la relation entre la musique et la plasticite cerebrale ? Apres une introduction sur l’interet neuroscientifique pour la musique et les processus de plasticite cerebrale, cet article vise a presenter les principaux resultats sur la neuroplasticite induite par la musique. Les effets de la formation et de l’expertise musicales sur le cerveau sont d’abord examines. Puis sont abordes et discutes du point de vue de la remediation neurologique l’importance de la stimulation et des changements du cerveau lies a la musique sur la stimulation d’autres fonctions non musicales.

A long-standing debate in cognitive neurosciences concerns the effect of music on verbal learning and memory. Research in this field has largely provided conflicting results in both clinical as well as non-clinical populations. Although several studies have shown a positive effect of music on the encoding and retrieval of verbal stimuli, music has also been suggested to hinder mnemonic performance by dividing attention. In an attempt to explain this conflict, we review the most relevant literature on the effects of music on verbal learning and memory. Furthermore, we specify several mechanisms through which music may modulate these cognitive functions. We suggest that the extent to which music boosts these cognitive functions relies on experimental factors, such as the relative complexity of musical and verbal stimuli employed. These factors should be carefully considered in further studies, in order to reliably establish how and when music boosts verbal memory and learning. The answers to these questions are not only crucial for our knowledge of how music influences cognitive and brain functions, but may have important clinical implications. Considering the increasing number of approaches using music as a therapeutic tool, the importance of understanding exactly how music works can no longer be underestimated.

Contains fulltext : 207577.pdf (Publisher’s version ) (Open Access) Brain imaging methods have contributed to shed light on the mechanisms of recovery after early brain insult. The assumption that the unaffected right hemisphere can take over language functions after left perinatal stroke is still under debate. Here, we report how patterns of brain structural and functional reorganization were associated with language outcomes in a group of four-year-old children with left perinatal arterial ischemic stroke (PAIS). Specifically, we gathered specific fine-grained developmental measures of receptive and productive aspects of language as well as standardized measures of cognitive development. We also collected structural neuroimaging data as well as functional activations during a passive listening story-telling fMRI task and a resting state session (rs-fMRI). Children with a left perinatal stroke showed larger lateralization indices of both structural and functional connectivity of the dorsal language pathway towards the right hemisphere that, in turn, were associated with better language outcomes. Importantly, the pattern of structural asymmetry was significantly more right-lateralized in children with a left perinatal brain insult than in a group of matched healthy controls. These results strongly suggest that early lesions of the left dorsal pathway and the associated perisylvian regions can induce the interhemispheric transfer of language functions to right homolog regions. This study provides combined evidence of structural and functional brain reorganization of language networks after early stroke with strong implications for neurobiological models of language development. 18 p.

In a society that is getting considerably older, it becomes important to identify potential mechanisms promoting successful aging to prevent, limit, and rehabilitate cognitive and emotional impairments typical of normal or pathological aging. Music is a powerful stimulus able to modulate widespread brain activations. Recent research has increasingly considered music as a promising, stimulating training and rehabilitation tool for improving cognition and promoting well-being and social connection. This chapter provides an overview of recent research investigating music and aging. It first focuses on the effects of music in normal aging, both in terms of musical expertise and simple musical exposure, with an additional section being devoted to the underlying brain processes. The chapter then considers the principal music-based therapeutic approaches used in pathological aging. Finally, the chapter underlines the main limitations and open questions arising from the existing literature, and discusses possible future directions for research on music and the aging brain.

We recently provided evidence that an intrinsic reward-related signal—triggered by successful learning in absence of any external feedback—modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop; Ripollés et al., 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this learning process is indeed dopamine-dependent. A group of healthy individuals completed three behavioral sessions of a language-learning task after the intake of different pharmacological treatments: a dopaminergic precursor, a dopamine receptor antagonist or a placebo. Results show that the pharmacological intervention modulated behavioral measures of both learning and pleasantness, inducing memory benefits after 24 hr only for those participants with a high sensitivity to reward. These results provide causal evidence for a dopamine-dependent mechanism instrumental in intrinsically regulated learning and further suggest that subject-specific reward sensitivity drastically alters learning success.

We recently provided evidence that an intrinsic reward-related signal—triggered by successful learning in absence of any external feedback—modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop; Ripollés et al., 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this learning process is indeed dopamine-dependent. A group of healthy individuals completed three behavioural sessions of our learning task after the intake of different pharmacological treatments: a dopaminergic precursor, a dopamine receptor antagonist or a placebo. Results show that the pharmacological intervention bidirectionally modulated behavioral measures of both learning and pleasantness, inducing memory benefits after 24 hours only for those participants with a high sensitivity to reward. These results provide causal evidence for a dopamine-dependent mechanism instrumental in intrinsically regulated learning, and further suggest that subject-specific dopamine sensitivity drastically alters learning success.

Music represents a special type of reward involving the recruitment of the mesolimbic dopaminergic system. According to recent theories on episodic memory formation, as dopamine strengthens the synaptic potentiation produced by learning, stimuli triggering dopamine release could result in long-term memory improvements. Here, we behaviourally test whether music-related reward responses could modulate episodic memory performance. Thirty participants rated (in terms of arousal, familiarity, emotional valence, and reward) and encoded unfamiliar classical music excerpts. Twenty-four hours later, their episodic memory was tested (old/new recognition and remember/know paradigm). Results revealed an influence of music-related reward responses on memory: excerpts rated as more rewarding were significantly better recognized and remembered. Furthermore, inter-individual differences in the ability to experience musical reward, measured through the Barcelona Music Reward Questionnaire, positively predicted memory performance. Taken together, these findings shed new light on the relationship between music, reward and memory, showing for the first time that music-driven reward responses are directly implicated in higher cognitive functions and can account for individual differences in memory performance.

La Spectroscopie proche infrarouge (Near-Infrared Spectroscopy, NIRS) est une technique d’imagerie cerebrale optique qui etudie l’activite cerebrale en mesurant les changements d’oxygenation cerebrale. Cette technique est non invasive, portable et peu sensible aux mouvements. Cette breve synthese a pour objectif de montrer les avantages de la NIRS et plus specifiquement pour les recherches en Psychologie, en proposant differents exemples de recherches qui ont utilise la NIRS notamment en psychologie cognitive, du developpement et dans le domaine clinique. L’objectif principal de cette synthese est de proposer une explication simple pour les chercheurs qui seraient interesses par cette technique. Ainsi, dans une premiere partie nous presentons son utilisation dans des tâches motrices, auditives et visuelles simples ainsi que dans des tâches impliquant des processus cognitifs de haut niveau. Dans une deuxieme partie, nous nous attachons davantage a decrire son utilisation dans differentes populations (nourrissons, enfants et adultes âges). Puis, nous presentons les possibles applications de cette technique a des populations cliniques, telles que les patients souffrant de troubles psychiatriques ou encore les personnes atteintes de la maladie d’Alzheimer. En conclusion, nous presentons les principaux avantages et limites de la NIRS compares a d’autres techniques de neuroimagerie.

Lors de la reconnaissance d’une information en memoire, les sujets âges reconnaissent moins d’informations en se rememorant le contexte d’encodage d’origine. Un deficit d’encodage a ete propose comme un des principaux determinants des differences liees a l’âge sur la rememoration. Cette etude a ete menee afin de voir si les sujets âges pouvaient beneficier de l’encodage en reference a soi pour augmenter la rememoration d’une information et ainsi compenser leurs deficits. Un groupe de 20 sujets jeunes et un groupe de 20 sujets âges ont encode des mots soit en reference a soi, soit en donnant une definition generale du mot, puis ont ete soumis a un test de reconnaissance associant le paradigme Remember/Know de Gardiner et al. (2009). Les resultats ont montre que les differences liees a l’âge sur la rememoration disparaissaient lorsque l’information etait encodee en reference a soi. En conclusion, il apparait que les personnes âgees beneficient de l’encodage en reference a soi pour augmenter leur habilete a recuperer une information en accedant consciemment au contexte d’encodage.

Several neuroimaging studies of cognitive aging revealed deficits in episodic memory abilities as a result of prefrontal cortex (PFC) limitations. Improving episodic memory performance despite PFC deficits is thus a critical issue in aging research. Listening to music stimulates cognitive performance in several non-purely musical activities (e.g., language and memory). Thus, music could represent a rich and helpful source during verbal encoding and therefore help subsequent retrieval. Furthermore, such benefit could be reflected in less demand of PFC, which is known to be crucial for encoding processes. This study aimed to investigate whether music may improve episodic memory in older adults while decreasing the PFC activity. Sixteen healthy older adults (μ = 64.5 years) encoded lists of words presented with or without a musical background while their dorsolateral prefrontal cortex (DLPFC) activity was monitored using a eight-channel continuous-wave near-infrared spectroscopy (NIRS) system (Oxymon Mk III, Artinis, The Netherlands). Behavioral results indicated a better source-memory performance for words encoded with music compared to words encoded with silence (p

Listening to music engages the whole brain, thus stimulating cognitive performance in a range of non-purely musical activities such as language and memory tasks. This article addresses an ongoing debate on the link between music and memory for words. While evidence on healthy and clinical populations suggests that music listening can improve verbal memory in a variety of situations, it is still unclear what specific memory process is affected and how. This study was designed to explore the hypothesis that music specifically benefits the encoding part of verbal memory tasks, by providing a richer context for encoding and therefore less demand on the dorsolateral prefrontal cortex (DLPFC). Twenty-two healthy young adults were subjected to functional near-infrared spectroscopy (fNIRS) imaging of their bilateral DLPFC while encoding words in the presence of either a music or a silent background. Behavioral data confirmed the facilitating effect of music background during encoding on subsequent item recognition. fNIRS results revealed significantly greater activation of the left hemisphere during encoding (in line with the HERA model of memory lateralization) and a sustained, bilateral decrease of activity in the DLPFC in the music condition compared to silence. These findings suggest that music modulates the role played by the DLPFC during verbal encoding, and open perspectives for applications to clinical populations with prefrontal impairments, such as elderly adults or Alzheimer’s patients.