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Dopamine modulates the reward experiences elicited by music
- Source :
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, Proceedings of the National Academy of Sciences of the United States of America, 116(9), 3793-3798. National Academy of Sciences
- Publication Year :
- 2019
- Publisher :
- Proceedings of the National Academy of Sciences, 2019.
-
Abstract
- Understanding how the brain translates a structured sequence of sounds, such as music, into a pleasant and rewarding experience is a fascinating question which may be crucial to better understand the processing of abstract rewards in humans. Previous neuroimaging findings point to a challenging role of the dopaminergic system in music-evoked pleasure. However, there is a lack of direct evidence showing that dopamine function is causally related to the pleasure we experience from music. We addressed this problem through a double blind within-subject pharmacological design in which we directly manipulated dopaminergic synaptic availability while healthy participants (n = 27) were engaged in music listening. We orally administrated to each participant a dopamine precursor (levodopa), a dopamine antagonist (risperidone), and a placebo (lactose) in three different sessions. We demonstrate that levodopa and risperidone led to opposite effects in measures of musical pleasure and motivation: while the dopamine precursor levodopa, compared with placebo, increased the hedonic experience and music-related motivational responses, risperidone led to a reduction of both. This study shows a causal role of dopamine in musical pleasure and indicates that dopaminergic transmission might play different or additive roles than the ones postulated in affective processing so far, particularly in abstract cognitive activities.
- Subjects :
- Adult
Male
Levodopa
media_common.quotation_subject
Emotions
NUCLEUS-ACCUMBENS
Administration, Oral
pleasure
Placebo
Pleasure
Young Adult
motivation
Dopamine
Commentaries
medicine
Humans
music
EMOTIONAL RESPONSES
BRAIN
ANTICIPATION
reward
media_common
Multidisciplinary
Risperidone
CORRELATE
LEVODOPA
Dopaminergic
Dopamine antagonist
Cognition
Placebo Effect
humanities
RECEPTOR OCCUPANCY
SEMANTIC ACTIVATION
LIKING
Dopamine Agonists
Auditory Perception
Female
dopamine
Psychology
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 116
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....52cef77175782d6a399a9be41c420859