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Intrinsically regulated learning is modulated by synaptic dopamine signaling
- Source :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, eLife, Vol 7 (2018), Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona, eLife, Elife, 7:e38113. eLife Sciences Publications, Ltd, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
- Publication Year :
- 2018
- Publisher :
- eLife Sciences Publications, Ltd, 2018.
-
Abstract
- We recently provided evidence that an intrinsic reward-related signal—triggered by successful learning in absence of any external feedback—modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop; Ripollés et al., 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this learning process is indeed dopamine-dependent. A group of healthy individuals completed three behavioral sessions of a language-learning task after the intake of different pharmacological treatments: a dopaminergic precursor, a dopamine receptor antagonist or a placebo. Results show that the pharmacological intervention modulated behavioral measures of both learning and pleasantness, inducing memory benefits after 24 hr only for those participants with a high sensitivity to reward. These results provide causal evidence for a dopamine-dependent mechanism instrumental in intrinsically regulated learning and further suggest that subject-specific reward sensitivity drastically alters learning success.
- Subjects :
- Male
0301 basic medicine
Physiology
Dopamine
Dopamine Agents
Hippocampus
EPISODIC MEMORY
Hippocampal formation
Synaptic Transmission
memory
0302 clinical medicine
PARKINSONS-DISEASE
Aprenentatge
Biology (General)
word learning
reward
Language
learning
APHASIA THERAPY
REWARD RESPONSES
General Neuroscience
Dopaminergic
Carbidopa
General Medicine
Risperidone
LONG-TERM-MEMORY
medicine.anatomical_structure
Medicine
Female
CA1 REGION
dopamine
Psychology
Signal Transduction
Human
medicine.drug
Adult
ENHANCES EXPLICIT
Cellular signal transduction
Memory, Long-Term
QH301-705.5
Science
NUCLEUS-ACCUMBENS
Fisiologia
Placebo
General Biochemistry, Genetics and Molecular Biology
Midbrain
Young Adult
03 medical and health sciences
Double-Blind Method
Reward
Memory
medicine
Humans
Learning
Word learning
Neural transmission
language
General Immunology and Microbiology
Mechanism (biology)
LEVODOPA
Ventral striatum
Transducció de senyal cel·lular
SEMANTIC ACTIVATION
030104 developmental biology
Dopamine Antagonists
Neurotransmissió
Research Advance
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 2050084X
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....2b04cbd61bec82e7abe0ce81fe1d44e6