Search

Your search keyword '"Kobayashi M"' showing total 22,453 results
Start Over Author "Kobayashi M"
22,453 results on '"Kobayashi M"'

1. Impact of Different Treatments for Disseminated Intravascular Coagulation on Patients with or without Biliary Drainage for Severe Biliary Tract Infection

Author

Kobayashi M, Takai S, Sakurai K, and Ehama Y

Subjects
sepsis, antithrombin, recombinant thrombomodulin, dic treatment, acute cholangitis, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Makoto Kobayashi,1 Shun Takai,2 Kyohei Sakurai,3 Yoshimatsu Ehama3 1Director of Surgery and Intensive Care Center, Hakodate Goryokaku Hospital, Hakodate City, Hokkaido, Japan; 2Division of Gastroenterology, Hakodate Goryokaku Hospital, Hakodate City, Hokkaido, Japan; 3Division of Emergency Medicine, Hakodate Goryokaku Hospital, Hakodate City, Hokkaido, JapanCorrespondence: Makoto Kobayashi, Director of Surgery and Intensive Care Center, Hakodate Goryokaku Hospital, 38-3 Goryokaku-cho, Hakodate City, Hokkaido, 040-8611, Japan, Tel +81-138-51-2295, Fax +81-56-2695, Email mobilecoba@me.comObjective: Sepsis caused by severe acute cholangitis requires biliary drainage to decrease the intra-biliary pressure. Furthermore, several studies showed that anticoagulant treatment can improve the outcomes of patients with sepsis-associated disseminated intravascular coagulation (DIC). There were reports examining the efficacy of anti-DIC drugs in patients undergoing biliary drainage with sepsis-associated DIC, and no reports compared the efficacy of DIC treatments when no drainage is performed. In this study, the influence of antithrombin (AT) replacement therapy and recombinant thrombomodulin (rTM) preparations on the overall survival (OS) of patients with and without biliary drainage was analyzed.Patients and Methods: This retrospective cohort study in a single institution involved patients with sepsis-associated DIC caused by severe biliary tract infection. In total, 71 patients treated by either AT replacement therapy or rTM preparation were assessed for inclusion. The two groups were patients with biliary drainage (n = 45) and without drainage (n = 26). To assess the clinical efficacy of anti-DIC drugs in each group, the 60-day OS was determined through estimated survival analysis.Results: Focusing on the effects of different therapeutic agents for DIC, in the group of patients with biliary drainage, OS showed no difference between patients treated by rTM and AT. However, in patients without biliary drainage, the survival curves of patients treated with AT replacement were lower than those of patients with rTM preparation.Conclusion: This study revealed that the OS of patients without biliary drainage differed depending on the DIC therapeutic agent for sepsis-associated DIC caused by acute cholangitis. We would recommend the use of rTM preparation over AT replacement therapy for patients who cannot undergo biliary drainage.Keywords: sepsis, antithrombin, recombinant thrombomodulin, DIC treatment, acute cholangitis

Published
2023

2. Preferences for Rehabilitation in Persons with a History of Stroke: A Discrete Choice Experiment

Author

Noto S, Murata T, Saito S, Watanabe T, and Kobayashi M

Subjects
stroke, rehabilitation, preference, physical therapy, occupational therapy, Medicine (General), R5-920
Abstract

Shinichi Noto,1 Tatsunori Murata,2 Shota Saito,2 Takahiro Watanabe,3 Makoto Kobayashi2 1Department of Rehabilitation, Niigata University of Health and Welfare, Niigata, Japan; 2CRECON Medical Assessment Inc, Tokyo, Japan; 3Rehabilitation Center, Niigata University Medical and Dental General Hospital, Niigata, JapanCorrespondence: Shinichi Noto, Department of Rehabilitation, Niigata University of Health and Welfare, 1398 Shimami, Kita-ku, Niigata, Japan, Email noto@nuhw.ac.jpObjective: To investigate the preferences of persons with a history of stroke for various attributes of rehabilitation using a discrete choice experiment (DCE).Design: Cross-sectional study.Setting: A web-based survey.Participants: A total of 600 adults with a history of stroke who were not asked whether or not they had participated in previous rehabilitation.Intervention: None.Main Outcome Measures: Preference weights by attribute ie, treatment time (30 minutes, one hour, one and a half hours), treatment content (walking exercises, activities of daily living; ADL exercises), priority treatment of paralyzed limbs (upper extremity, lower upper extremity), treatment location (hospital visit, home visit), therapist gender, and out-of-pocket costs for stroke rehabilitation using discrete choice experiment.Results: The most common self-reported diagnosis was cerebral infarction (408 patients, 68%). The mean age was 62.0 ± 9.8 years, and 515 (85.8%) were male. Of the five attributes, excluding out-of-pocket costs, the highest relative importance score was treatment location (0.331), followed by treatment time (0.304). Among the rehabilitation programs, the statistically significant coefficients calculated were one hour of therapy (0.173, 95% CI = 0.088– 0.258), hospital visits (0.241, 95% CI = 0.180– 0.303), and female therapists (0.186, 95% CI = 0.125– 0. 247). No significant differences were obtained regarding the treatment contents or the paralyzed limb to be treated.Conclusion: A discrete choice experiment revealed that persons with a history of stroke prefer a one-hour hospital rehabilitation program with a female therapist, with cost being a major consideration for rehabilitation. The results of this study may provide useful information for rehabilitation professionals.Keywords: stroke, rehabilitation, preference, physical therapy, occupational therapy

Published
2023

3. The Necessity of Individualized Treatment for Sepsis-Associated Disseminated Intravascular Coagulation by Infected Organ

Author

Kobayashi M, Ehama Y, and Hirayama S

Subjects
antithrombin, recombinant thrombomodulin, overall survival, biliary tract infection, respiratory tract infection, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Makoto Kobayashi,1 Yoshimatsu Ehama,2 Suguru Hirayama2 1Intensive Care Center, Hakodate Goryoukaku Hospital, Hakodate City, Hokkaido, Japan; 2Department of Emergency Medicine, Hakodate Goryoukaku Hospital, Hakodate City, Hokkaido, JapanCorrespondence: Makoto Kobayashi, Hakodate Goryoukaku Hospital, 38-3 Goryoukaku-cho, Hakodate City, Hokkaido, 040-8611, Japan, Tel +81-138-51-2295, Fax +81-138-56-2695, Email koba86gg@gmail.comObjective: Several studies have shown that anticoagulation can improve survival outcomes in patients with sepsis-associated disseminated intravascular coagulation (DIC). A guideline from Japan in 2020 suggested two therapeutic agents for sepsis-associated DIC treatment: antithrombin (AT) replacement therapy and recombinant thrombomodulin (rTM) preparation. In 2021, our preliminary study proposed that different organs of septic infection might lead to distinct treatment outcomes following different therapies against DIC. In this study, we created a subanalysis on the influence of AT replacement therapy and rTM preparations on overall survival (OS) by comparing two causative organs: biliary and respiratory tract infections.Patients and Methods: This retrospective cohort study in a single institution involved patients with sepsis-associated DIC treated by either AT or rTM who were categorized based on sources of infection. The two groups defined for this study were biliary (n = 62) and respiratory tract infection (n = 84). To assess the clinical efficacy of AT and rTM, 30-day OS was examined using a stepwise variable selection for a Cox proportional hazards model.Results: The analysis of factors influencing OS by each group showed that rTM preparation remained a significant factor in the biliary tract infection group (HR 0.306, 95% CI 0.133– 0.706). In the respiratory tract infection group, the score of the Acute Physiology and Chronic Health Evaluation II (HR 1.109, 95% CI 1.051– 1.170), polymyxin B hemoperfusion (HR 0.390, 95% CI 0.161– 0.944), and AT replacement therapy (HR 0.510, 95% CI 0.261– 0.997) were established as significant factors.Conclusion: This study revealed that the OS of patients with biliary tract and respiratory tract infections differed depending on the DIC therapeutic agent. Based on these results, we could suggest that it is necessary to develop individualized treatment strategies for septic infections, taking into consideration the differences in the infected organs.Graphal Abstract: Keywords: antithrombin, recombinant thrombomodulin, overall survival, biliary tract infection, respiratory tract infection

Published
2022

4. A Study on the Impact of Surgical Duration on Esophageal Cancer

Author

Kobayashi M, Yoshida E, Kyuno T, Kawagishi R, Sato K, Kono T, Chiba T, Yonezawa H, Funato O, and Takagane A

Subjects
esophagectomy, ivor-lewis approach, depth of tumor invasion, lymph node metastasis, body mass index, overall survival, Surgery, RD1-811
Abstract

Makoto Kobayashi, Eiji Yoshida, Takuro Kyuno, Ryoko Kawagishi, Kei Sato, Tsuyoshi Kono, Takehiro Chiba, Hitoshi Yonezawa, Osamu Funato, Akinori Takagane Department of Surgery, Hakodate Goryoukaku Hospital, Hakodate City, Hokkaido, 040-8611, JapanCorrespondence: Makoto KobayashiDepartment of Surgery, Hakodate Goryoukaku Hospital, 38-3 Goryoukaku-cho, Hakodate City, Hokkaido, 040-8611, JapanTel +81-138-51-2295Fax +81-138-56-2696Email koba86gg@gmail.comPurpose: Faster surgery has been associated with better outcomes. In the present study, we aimed to determine whether surgical duration affected overall survival (OS) in patients undergoing esophagectomy. Additionally, we assessed factors that influence surgical duration.Patients and Methods: This single-center retrospective cohort study included 128 patients who underwent Ivor-Lewis esophagectomy by a single surgeon between 2005 and 2019. The Cox proportional hazard model was used to evaluate the association of OS with the following variables: surgical duration, neo-adjuvant chemotherapy, pathological grade of depth of tumor invasion, lymph node (LN) metastasis, body mass index (BMI), and cervical LN dissection. Additionally, factors associated with prolonged surgical duration were examined by logistic regression analysis.Results: Based on the multivariate analysis, surgical duration was not associated with OS [hazard ratio (HR), 1.065; 95% confidence interval (CI), 0.586– 1.937; P = 0.837]. On the other hand, tumor invasion (HR, 2.901; 95% CI, 1.483– 5.674; P = 0.002) and LN metastasis (HR, 2.338 2.403; 95% CI, 1.237– 4.420 1.257– 4.593; P = 0.009 0.008) significantly influenced OS. The assessment of variables affecting surgical duration showed that BMI had a significant effect on surgical duration (odds ratio, 2.790; 95% CI, 1.254– 6.204, P = 0.012).Conclusion: According to the analysis of patients who underwent the same surgical approach by a single surgeon, surgical duration of esophagectomy for esophageal cancer was significantly influenced by BMI; however, surgical duration had no impact on patient survival.Keywords: esophagectomy, Ivor-Lewis approach, depth of tumor invasion, lymph node metastasis, body mass index, overall survival

Published
2021

5. First Measurement of Solar $^8$B Neutrinos via Coherent Elastic Neutrino-Nucleus Scattering with XENONnT

Author

Aprile, E., Aalbers, J., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Martin, D. Antón, Arneodo, F., Baudis, L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Boese, K., Brown, A., Bruno, G., Budnik, R., Cai, C., Capelli, C., Cardoso, J. M. R., Chávez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., D'Andrea, V., Garcia, L. C. Daniel, Decowski, M. P., Deisting, A., Di Donato, C., Di Gangi, P., Diglio, S., Eitel, K., Elykov, A., Ferella, A. D., Ferrari, C., Fischer, H., Flehmke, T., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Ghosh, S., Giacomobono, R., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Gyorgy, P., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Kaminaga, Y., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koke, D., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lin, Y. -T., Lindemann, S., Lindner, M., Liu, K., Liu, M., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Luce, T., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, E., Mastroianni, S., Melchiorre, A., Merz, J., Messina, M., Michael, A., Miuchi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Pan, Y., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Plante, G., Pollmann, T. R., Principe, L., Qi, J., Qin, J., García, D. Ramírez, Rajado, M., Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shi, J., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Thers, D., Toschi, F., Trinchero, G., Tunnell, C. D., Tönnies, F., Valerius, K., Vecchi, S., Vetter, S., Solar, F. I. Villazon, Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., and Zhong, M.

Subjects
Nuclear Experiment, Astrophysics - Solar and Stellar Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We present the first measurement of nuclear recoils from solar $^8$B neutrinos via coherent elastic neutrino-nucleus scattering with the XENONnT dark matter experiment. The central detector of XENONnT is a low-background, two-phase time projection chamber with a 5.9\,t sensitive liquid xenon target. A blind analysis with an exposure of 3.51\,t$\times$y resulted in 37 observed events above 0.5\,keV, with ($26.4^{+1.4}_{-1.3}$) events expected from backgrounds. The background-only hypothesis is rejected with a statistical significance of 2.73\,$\sigma$. The measured $^8$B solar neutrino flux of $(4.7_{-2.3}^{+3.6})\times 10^6\,\mathrm{cm}^{-2}\mathrm{s}^{-1}$ is consistent with results from dedicated solar neutrino experiments. The measured neutrino flux-weighted CE$\nu$NS cross-section on Xe of $(1.1^{+0.8}_{-0.5})\times10^{-39}\,\mathrm{cm}^2$ is consistent with the Standard Model prediction. This is the first direct measurement of nuclear recoils from solar neutrinos with a dark matter detector.

Published
2024

6. XENONnT WIMP Search: Signal & Background Modeling and Statistical Inference

Author

XENON Collaboration, Aprile, E., Aalbers, J., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Martin, D. Antón, Arneodo, F., Baudis, L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Boese, K., Brown, A., Bruno, G., Budnik, R., Cardoso, J. M. R., Chávez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., D'Andrea, V., Garcia, L. C. Daniel, Decowski, M. P., Di Donato, C., Di Gangi, P., Diglio, S., Eitel, K., Elykov, A., Ferella, A. D., Ferrari, C., Fischer, H., Flehmke, T., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Ghosh, S., Giacomobono, R., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Gyoergy, P., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Kaminaga, Y., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lin, Y. -T., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Luce, T., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, E., Mastroianni, S., Melchiorre, A., Messina, M., Michael, A., Miuchi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Pan, Y., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Plante, G., Pollmann, T. R., Principe, L., Qi, J., Qin, J., García, D. Ramírez, Rajado, M., Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shi, J., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C. D., Tönnies, F., Valerius, K., Vecchi, S., Vetter, S., Solar, F. I. Villazon, Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., and Zhong, M.

Subjects
Physics - Data Analysis, Statistics and Probability, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The XENONnT experiment searches for weakly-interacting massive particle (WIMP) dark matter scattering off a xenon nucleus. In particular, XENONnT uses a dual-phase time projection chamber with a 5.9-tonne liquid xenon target, detecting both scintillation and ionization signals to reconstruct the energy, position, and type of recoil. A blind search for nuclear recoil WIMPs with an exposure of 1.1 tonne-years yielded no signal excess over background expectations, from which competitive exclusion limits were derived on WIMP-nucleon elastic scatter cross sections, for WIMP masses ranging from 6 GeV/$c^2$ up to the TeV/$c^2$ scale. This work details the modeling and statistical methods employed in this search. By means of calibration data, we model the detector response, which is then used to derive background and signal models. The construction and validation of these models is discussed, alongside additional purely data-driven backgrounds. We also describe the statistical inference framework, including the definition of the likelihood function and the construction of confidence intervals., Comment: 20 pages, 10 figures

Published
2024

7. First joint oscillation analysis of Super-Kamiokande atmospheric and T2K accelerator neutrino data

Author

Super-Kamiokande, collaborations, T2K, Abe, S., Abe, K., Akhlaq, N., Akutsu, R., Alarakia-Charles, H., Ali, A., Hakim, Y. I. Alj, Monsalve, S. Alonso, Amanai, S., Andreopoulos, C., Anthony, L. H. V., Antonova, M., Aoki, S., Apte, K. A., Arai, T., Arihara, T., Arimoto, S., Asada, Y., Asaka, R., Ashida, Y., Atkin, E. T., Babu, N., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Bates, P., Batkiewicz-Kwasniak, M., Beauchêne, A., Berardi, V., Berns, L., Bhadra, S., Bhuiyan, N., Bian, J., Blanchet, A., Blondel, A., Bodur, B., Bolognesi, S., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bubak, A., Avanzini, M. Buizza, Burton, G. T., Caballero, J. A., Calabria, N. F., Cao, S., Carabadjac, D., Carter, A. J., Cartwright, S. L., Casado, M. P., Catanesi, M. G., Cervera, A., Chakrani, J., Chalumeau, A., Chen, S., Cherdack, D., Choi, K., Chong, P. S., Chvirova, A., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cormier, F., Cudd, A., Dalmazzone, C., Daret, T., Dasgupta, P., Davis, C., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Dharmapal, R., Di Lodovico, F., Lopez, G. Diaz, Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Duffy, K. E., Dumarchez, J., Dunne, P., Dygnarowicz, K., D'ago, D., Edwards, R., Eguchi, A., Elias, J., Emery-Schrenk, S., Erofeev, G., Ershova, A., Eurin, G., Fannon, J. E. P., Fedorova, D., Fedotov, S., Feltre, M., Feng, J., Feng, L., Ferlewicz, D., Fernandez, P., Finch, A. J., Aguirre, G. A. Fiorentini, Fiorillo, G., Fitton, M. D., Patiño, J. M. Franco, Friend, M., Fujii, Y., Fujisawa, C., Fujita, S., Fukuda, Y., Furui, Y., Gao, J., Gaur, R., Giampaolo, A., Giannessi, L., Giganti, C., Glagolev, V., Goldsack, A., Gonin, M., Rosa, J. González, Goodman, E. A. G., Gorin, A., Gorshanov, K., Gousy-Leblanc, V., Grassi, M., Griskevich, N. J., Guigue, M., Hadley, D., Haigh, J. T., Han, S., Harada, M., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hayato, Y., Heitkamp, I., Henaff, D., Hill, J., Hino, Y., Hiraide, K., Hogan, M., Holeczek, J., Holin, A., Holvey, T., Van, N. T. Hong, Honjo, T., Horiuchi, S., Hosokawa, K., Hu, Z., Hu, J., Iacob, F., Ichikawa, A. K., Ieki, K., Ikeda, M., Iovine, N., Ishida, T., Ishino, H., Ishitsuka, M., Ishizuka, T., Ito, H., Itow, Y., Izmaylov, A., Izumiyama, S., Jakkapu, M., Jamieson, B., Jang, M. C., Jang, J. S., Jenkins, S. J., Jesús-Valls, C., Ji, J. Y., Jia, M., Jiang, J., Jonsson, P., Joshi, S., Jung, C. K., Jung, S., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kanemura, Y., Kaneshima, R., Karpova, S., Kasetti, S. P., Kashiwagi, Y., Kasturi, V. S., Kataoka, Y., Katori, T., Kawamura, Y., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kim, S. B., King, S., Kiseeva, V., Kisiel, J., Kneale, L., Kobayashi, H., Kobayashi, T., Kobayashi, M., Koch, L., Kodama, S., Kolupanova, M., Konaka, A., Kormos, L. L., Koshio, Y., Koto, T., Kowalik, K., Kudenko, Y., Kudo, Y., Kuribayashi, S., Kurjata, R., Kurochka, V., Kutter, T., Kuze, M., Kwon, E., La Commara, M., Labarga, L., Lachat, M., Lachner, K., Lagoda, J., Lakshmi, S. M., LamersJames, M., Langella, A., Laporte, J. -F., Last, D., Latham, N., Laveder, M., Lavitola, L., Lawe, M., Learned, J. G., Lee, Y., Lee, S. H., Silverio, D. Leon, Levorato, S., Lewis, S., Li, X., Li, W., Lin, C., Litchfield, R. P., Liu, S. L., Liu, Y. M., Long, K. R., Longhin, A., Moreno, A. Lopez, Lu, X., Ludovici, L., Lux, T., Machado, L. N., Maekawa, Y., Magaletti, L., Mahn, K., Mahtani, K. K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Martens, K., Marti, Ll., Martin, D. G. R., Martin, J. F., Martin, D., Martini, M., Maruyama, T., Matsubara, T., Matsumoto, R., Mattiazzi, M., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., McCauley, N., McElwee, J. M., McFarland, K. S., McGrew, C., McKean, J., Mefodiev, A., Megias, G. D., Mehta, P., Mellet, L., Menjo, H., Metelko, C., Mezzetto, M., Migenda, J., Mijakowski, P., Miki, S., Miller, E., Minamino, A., Mine, S., Mineev, O., Mirabito, J., Miura, M., Bueno, L. Molina, Moon, D. H., Mori, M., Moriyama, S., Morrison, P., Muñoz, A., Mueller, Th. A., Munford, D., Munteanu, L., Nagai, Y., Nagai, K., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, K., Nakamura, K. D., Nakamura, T., Nakanishi, F., Nakano, Y., Nakaya, T., Nakayama, S., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Nguyen, D. T., Nicholson, M., Niewczas, K., Ninomiya, K., Nishijima, K., Nishimori, S., Nishimura, Y., Noguchi, Y., Nosek, T., Nova, F., Novella, P., Nugent, J. C., Odagawa, T., Okazaki, R., Okazawa, H., Okinaga, W., Okumura, K., Okusawa, T., Ommura, Y., Onda, N., Ospina, N., Osu, L., Oyama, Y., O'Flaherty, M., O'Keeffe, H. M., O'Sullivan, L., Périssé, L., Paganini, P., Palladino, V., Paolone, V., Pari, M., Park, R. G., Parlone, J., Pasternak, J., Payne, D., Penn, G. C., de Perio, P., Pershey, D., Pfaff, M., Pickering, L., Pintaudi, G., Pistillo, C., Pointon, B. W., Popov, B., Yrey, A. Portocarrero, Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Prasad, H., Pronost, G., Prouse, N. W., Pupilli, F., Quilain, B., Quyen, P. T., Raaf, J. L., Radermacher, T., Radicioni, E., Radics, B., Ramirez, M. A., Ramsden, R. M., Ratoff, P. N., Reh, M., Riccio, C., Richards, B., Rogly, R., Rondio, E., Roth, S., Roy, N., Rubbia, A., Russo, L., Rychter, A., Saenz, W., Sakai, S., Sakashita, K., Samani, S., Santos, A. D., Sato, Y., Sato, K., Schefke, T., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Seo, J. W., Sgalaberna, D., Shaikhiev, A., Shi, W., Shiba, H., Shibayama, R., Shigeta, N., Shima, S., Shimamura, R., Shimizu, K., Shinoki, M., Shiozawa, M., Shiraishi, Y., Shvartsman, A., Skrobova, N., Skwarczynski, K., Smy, M. B., Smyczek, D., Sobczyk, J. T., Sobel, H. W., Soler, F. J. P., Sonoda, Y., Speers, A. J., Spina, R., Stroke, Y., Suslov, I. A., Suvorov, S., Suzuki, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sánchez, F., Tada, T., Tada, M., Tairafune, S., Takagi, Y., Takeda, A., Takemoto, Y., Takeuchi, Y., Takhistov, V., Takifuji, K., Tanaka, H., Tanaka, H. K., Tanigawa, H., Taniuchi, N., Tano, T., Tarrant, A., Tashiro, T., Teklu, A., Terada, K., Tereshchenko, V. V., Thamm, N., Thiesse, M. D., Thompson, L. F., Toki, W., Tomiya, T., Touramanis, C., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M. R., Vargas, D., Varghese, M., Vasseur, G., Villa, E., Vinning, W. G. S., Virginet, U., Vladisavljevic, T., Wachala, T., Wakabayashi, D., Wallace, H. T., Walsh, J. G., Walter, C. W., Wan, L., Wang, X., Wang, Y., Wark, D., Wascko, M. O., Watanabe, E., Weber, A., Wendell, R. A., Wester, T., Wilking, M. J., Wilkinson, C., Wilson, S. T., Wilson, J. R., Wood, K., Wret, C., Wu, Y., Xia, J., Xie, Z., Xu, B. D., Xu, Y. -H., Yamamoto, K., Yamamoto, T., Yamauchi, K., Yanagisawa, C., Yang, G., Yang, B. S., Yang, J. Y., Yankelevich, A., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoo, J., Yoshida, T., Yoshida, S., Yoshimoto, Y., Yoshimura, N., Yoshioka, Y., Yu, M., Yu, I., Zaki, R., Zaldivar, B., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhang, J., Zhang, A. Q., Zhang, B., Zhao, X. Y., Zhong, H., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zsoldos, S.

Subjects
High Energy Physics - Experiment
Abstract

The Super-Kamiokande and T2K collaborations present a joint measurement of neutrino oscillation parameters from their atmospheric and beam neutrino data. It uses a common interaction model for events overlapping in neutrino energy and correlated detector systematic uncertainties between the two datasets, which are found to be compatible. Using 3244.4 days of atmospheric data and a beam exposure of $19.7(16.3) \times 10^{20}$ protons on target in (anti)neutrino mode, the analysis finds a 1.9$\sigma$ exclusion of CP-conservation (defined as $J_{CP}=0$) and a preference for the normal mass ordering., Comment: 10 pages, 3 figures

Published
2024

8. Lifting of gap nodes by disorder in ultranodal superconductor candidate FeSe1-xSx

Author

Nagashima, T., Ishihara, K., Imamura, K., Kobayashi, M., Roppongi, M., Matsuura, K., Mizukami, Y., Grasset, R., Konczykowski, M., Hashimoto, K., and Shibauchi, T.

Subjects
Condensed Matter - Superconductivity
Abstract

The observation of time-reversal symmetry breaking and large residual density of states in tetragonal FeSe$_{1-x}$S$_x$ suggests a novel type of ultranodal superconducting state with Bogoliubov Fermi surfaces (BFSs). Although such BFSs in centrosymmetric superconductors are expected to be topologically protected, the impurity effect of this exotic superconducting state remains elusive experimentally. Here, we investigate the impact of controlled defects introduced by electron irradiation on the superconducting state of tetragonal FeSe$_{1-x}$S$_x$ ($0.18\le x\le 0.25$). The temperature dependence of magnetic penetration depth is initially consistent with a model with BFSs in the pristine sample. After irradiation, we observe a nonmonotonic evolution of low-energy excitations with impurity concentrations. This nonmonotonic change indicates a transition from nodal to nodeless, culminating in gapless with Andreev bound states, reminiscent of the nodal $s_\pm$ case. This points to the accidental nature of the possible BFSs in tetragonal FeSe$_{1-x}$S$_x$, which are susceptible to disruption by the disorder., Comment: 7 pages, 4 figures

Published
2024

9. Offline tagging of radon-induced backgrounds in XENON1T and applicability to other liquid xenon detectors

Author

Aprile, E., Aalbers, J., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruno, G., Budnik, R., Bui, T. K., Cardoso, J. M. R., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., D'Andrea, V., Garcia, L. C. Daniel, Decowski, M. P., Di Donato, C., Di Gangi, P., Diglio, S., Eitel, K., Elykov, A., Ferella, A. D., Ferrari, C., Fischer, H., Flehmke, T., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Ghosh, S., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kaminaga, Y., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lin, Y. T., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Luce, T., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, E., Mastroianni, S., Melchiorre, A., Messina, M., Michael, A., Miuchi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Pan, Y., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Plante, G., Pollmann, T. R., Principe, L., Qi, J., Qin, J., García, D. Ramírez, Rajado, M., Shi, J., Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Vecchi, S., Vetter, S., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

This paper details the first application of a software tagging algorithm to reduce radon-induced backgrounds in liquid noble element time projection chambers, such as XENON1T and XENONnT. The convection velocity field in XENON1T was mapped out using $^{222}\text{Rn}$ and $^{218}\text{Po}$ events, and the root-mean-square convection speed was measured to be $0.30 \pm 0.01$ cm/s. Given this velocity field, $^{214}\text{Pb}$ background events can be tagged when they are followed by $^{214}\text{Bi}$ and $^{214}\text{Po}$ decays, or preceded by $^{218}\text{Po}$ decays. This was achieved by evolving a point cloud in the direction of a measured convection velocity field, and searching for $^{214}\text{Bi}$ and $^{214}\text{Po}$ decays or $^{218}\text{Po}$ decays within a volume defined by the point cloud. In XENON1T, this tagging system achieved a $^{214}\text{Pb}$ background reduction of $6.2^{+0.4}_{-0.9}\%$ with an exposure loss of $1.8\pm 0.2 \%$, despite the timescales of convection being smaller than the relevant decay times. We show that the performance can be improved in XENONnT, and that the performance of such a software-tagging approach can be expected to be further improved in a diffusion-limited scenario. Finally, a similar method might be useful to tag the cosmogenic $^{137}\text{Xe}$ background, which is relevant to the search for neutrinoless double-beta decay., Comment: 17 pages, 19 figures

Published
2024

10. Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats

Author

Kobayashi M, Okada Y, Ueno H, Mizorogi T, Ohara K, Kawasumi K, Suruga K, Kadokura K, Ohnishi Y, and Arai T

Subjects
anti-inflammatory compound, cat, obesity, quercetin, saa, Veterinary medicine, SF600-1100
Abstract

Motoo Kobayashi,1,2,* Yuki Okada,1,2,* Hiromichi Ueno,1 Takayuki Mizorogi,1 Kenji Ohara,1 Koh Kawasumi,1 Kohei Suruga,3 Kazunari Kadokura,3 Yasuyuki Ohnishi,2 Toshiro Arai1,2 1Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8601, Japan; 2One Health Co. Ltd, Tokyo 157-0066, Japan; 3Food Function R&D Division, International Operation Department, Kibun Foods Inc., Tokyo 206-0812, Japan*These authors contributed equally to this workCorrespondence: Toshiro AraiLaboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8601, JapanTel +81 422 31 4151Fax +81 422 31 7841Email tarai@nvlu.ac.jpBackground: Obesity has become a serious public health problem all over the world, and prevalence of obesity has increased in cats. Obesity is characterized by continuous low-grade inflammation based on oxidative stress by excessively produced reactive oxygen species (ROS). Supplementation with anti-oxidant and anti-inflammatory compounds is very effective to relieve the obesity condition. A plant extract mixture containing Rhus verniciflua and some other herbs, Rv-PEM01-99, shows anti-oxidant and anti-inflammatory effects in animals. The aim of this study was to evaluate the effects of supplementation with Rv-PEM01-99 as an anti-inflammatory compound in healthy and obese cats.Materials and Methods: Ten healthy mix breed cats and four obesity disease cats were used. The healthy cats were randomly divided into control and test groups. Anti-inflammatory compound, Rv-PEM01-99, in which quercetin derivative is the main component, was supplemented to the healthy test group and the obesity disease cats at the dose of 100– 120 mg/kg/day (2.5– 3.0 mg/kg/day as quercetin) for 4 weeks. Metabolites, hormones and enzymes were measured before and after the compound supplementation.Results: The anti-inflammatory compound supplementation decreased serum amyloid A (SAA) concentrations as inflammatory markers in both healthy and obesity disease cats. In obesity disease cats, plasma total cholesterol concentrations and AST and ALT activities decreased significantly after the compound supplementation.Conclusion: Quercetin derivative seems to have strong anti-inflammatory activities. In the healthy cats, anti-inflammatory compound supplementation decreased plasma NEFA and SAA concentrations. In the obesity disease cats, the compound supplementation may have alleviated obesity disease by relieving inflammation and improvement of lipid metabolism in livers.Keywords: anti-inflammatory compound, cat, obesity, quercetin, SAA

Published
2020

11. Effects of astaxanthin supplementation in healthy and obese dogs

Author

Murai T, Kawasumi K, Tominaga K, Okada Y, Kobayashi M, and Arai T

Subjects
Astaxanthin supplementation, obese dogs, anti-oxidative activity, liver function, Veterinary medicine, SF600-1100
Abstract

Tae Murai,1 Koh Kawasumi,1 Kumi Tominaga,2 Yuki Okada,1 Motoo Kobayashi,1 Toshiro Arai1 1Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo 180-8602, Japan; 2Research and Development Division, AstaReal Co. Ltd., Minato-ku, Tokyo 105-0011, Japan Background: Since astaxanthin (ASX) has potent anti-oxidative effects with inhibitory action of lipid peroxidation and singlet oxygen quenching activity, it is widely used as a functional food for keeping good health in human. Obesity is a risk factor for various metabolic disorders. It is characterized by low-grade chronic inflammation based on oxidative stress by excessively produced ROS. From the point of preventive medicine, natural compounds have been proposed as potential therapeutic agents in the prevention of metabolic disorder in companion animals. The purpose of this study is to evaluate the effects of ASX supplementation in healthy and obese dogs. Materials and methods: Ten healthy beagle dogs and 5 clinically obese dogs were used in this study. The healthy beagle dogs were randomly divided into 2 groups as follows: control and test groups. The test group dogs received ASX supplementation mixed with the food for 6 weeks. Five clinically obese dogs received ASX supplementation for 8 weeks. Metabolites, hormones and enzymes were measured before and after ASX supplementation. Results: In the healthy dog groups, after 6 weeks, plasma triglyceride (TG) and malondialdehyde concentrations and lactate dehydrogenase (LDH) values significantly decreased in the test group. There was no significant difference in the control group. In clinically obese dogs, plasma TG concentration decreased after 8 weeks of ASX supplementation. Plasma alanine aminotransferase and LDH values clearly decreased in all 5 dogs and 4 dogs out of 5 dogs, respectively. Conclusion: ASX supplementation (0.3 mg/kg body weight/day) for 6 weeks in healthy dogs and 8 weeks in obese dogs induced the elevation of antioxidant function and of liver function by ameliorating lipid metabolism. Keywords: astaxanthin, obese dogs, lipid metabolism, anti-oxidative activity, liver function

Published
2019

12. Risk factors and clinical signs of severe Acanthamoeba keratitis

Author

Shimmura-Tomita M, Takano H, Kinoshita N, Toyoda F, Tanaka Y, Takagi R, Kobayashi M, and Kakehashi A

Subjects
Acanthamoeba keratitis, keratoprecipitates, steroid eye drops, aging, Ophthalmology, RE1-994
Abstract

Machiko Shimmura-Tomita, Hiroko Takano, Nozomi Kinoshita, Fumihiko Toyoda, Yoshiaki Tanaka, Rina Takagi, Mina Kobayashi, Akihiro Kakehashi Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, Saitama, Japan Purpose: To determine risk factors and clinical signs for severe Acanthamoeba keratitis (AK) by comparing severe cases with mild cases with good prognosis.Patients and methods: We reviewed medical records of ten cases of AK (five males and five females) referred to our hospital and classified cases into two groups. One eye that required therapeutic keratoplasty and three eyes with a poor visual acuity (

Published
2018

13. The XENONnT Dark Matter Experiment

Author

XENON Collaboration, Aprile, E., Aalbers, J., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Balata, M., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cassese, F., Chiarini, A., Cichon, D., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Corrieri, R., Cuenca-García, J. J., Cussonneau, J. P., Dadoun, O., D'Andrea, V., Decowski, M. P., De Fazio, B., Di Gangi, P., Diglio, S., Disdier, J. M., Douillet, D., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Form, S., Front, D., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Gardner, R., Garroum, N., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guerzoni, M., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Huhmann, C., Iacovacci, M., Iaquaniello, G., Iven, L., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martella, P., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Mele, E., Messina, M., Michinelli, R., Miuchi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Nisi, S., Oberlack, U., Orlandi, D., Othegraven, R., Paetsch, B., Palacio, J., Parlati, S., Paschos, P., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Plante, G., Pollmann, T. R., Qi, J., Qin, J., García, D. Ramírez, Rynge, M., Shi, J., Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Stephen, J., Stern, M., Stillwell, B. K., Takeda, A., Tan, P. -L., Tatananni, D., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Westermann, J., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The multi-staged XENON program at INFN Laboratori Nazionali del Gran Sasso aims to detect dark matter with two-phase liquid xenon time projection chambers of increasing size and sensitivity. The XENONnT experiment is the latest detector in the program, planned to be an upgrade of its predecessor XENON1T. It features an active target of 5.9 tonnes of cryogenic liquid xenon (8.5 tonnes total mass in cryostat). The experiment is expected to extend the sensitivity to WIMP dark matter by more than an order of magnitude compared to XENON1T, thanks to the larger active mass and the significantly reduced background, improved by novel systems such as a radon removal plant and a neutron veto. This article describes the XENONnT experiment and its sub-systems in detail and reports on the detector performance during the first science run., Comment: 32 pages, 19 figures

Published
2024

14. Mass, spectroscopy and two-neutron decay of $^{16}$Be

Author

Monteagudo, B., Marqués, F. M., Gibelin, J., Orr, N. A., Corsi, A., Kubota, Y., Casal, J., Gómez-Camacho, J., Authelet, G., Baba, H., Caesar, C., Calvet, D., Delbart, A., Dozono, M., Feng, J., Flavigny, F., Gheller, J. -M., Giganon, A., Gillibert, A., Hasegawa, K., Isobe, T., Kanaya, Y., Kawakami, S., Kim, D., Kiyokawa, Y., Kobayashi, M., Kobayashi, N., Kobayashi, T., Kondo, Y., Korkulu, Z., Koyama, S., Lapoux, V., Maeda, Y., Motobayashi, T., Miyazaki, T., Nakamura, T., Nakatsuka, N., Nishio, Y., Obertelli, A., Ohkura, A., Ota, S., Otsu, H., Ozaki, T., Panin, V., Paschalis, S., Pollacco, E. C., Reichert, S., Rousse, J. -Y., Saito, A. T., Sakaguchi, S., Sako, M., Santamaria, C., Sasano, M., Sato, H., Shikata, M., Shimizu, Y., Shindo, Y., Stuhl, L., Sumikama, T., Sun, Y. L., Tabata, M., Togano, Y., Tsubota, J., Uesaka, T., Yang, Z. H., Yasuda, J., Yoneda, K., and Zenihiro, J.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The structure and decay of the most neutron-rich beryllium isotope, $^{16}$Be, has been investigated following proton knockout from a high-energy $^{17}$B beam. Two relatively narrow resonances were observed for the first time, with energies of $0.84(3)$ and $2.15(5)$ MeV above the two-neutron decay threshold and widths of $0.32(8)$ and $0.95(15)$ MeV respectively. These were assigned to be the ground ($J^{\pi}=0^+$) and first excited ($2^+$) state, with $E_x=1.31(6)$ MeV. The mass excess of $^{16}$Be was thus deduced to be $56.93(13)$ MeV, some $0.5$ MeV more bound than the only previous measurement. Both states were observed to decay by direct two-neutron emission. Calculations incorporating the evolution of the wavefunction during the decay as a genuine three-body process reproduced the principal characteristics of the neutron-neutron energy spectra for both levels, indicating that the ground state exhibits a strong spatially compact dineutron component, while the 2$^+$ level presents a far more diffuse neutron-neutron distribution.

Published
2024

15. S100A16, a promising candidate as a prognostic marker for platinum-based adjuvant chemotherapy in resected lung adenocarcinoma

Author

Katono K, Sato Y, Kobayashi M, Nagashio R, Ryuge S, Igawa S, Ichinoe M, Murakumo Y, Saegusa M, and Masuda N

Subjects
S100A16, Lung adenocarcinoma, Platinum-based adjuvant chemotherapy, Immunohistochemistry, Prognostic marker, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Ken Katono,1 Yuichi Sato,2 Makoto Kobayashi,3 Ryo Nagashio,2 Shinichiro Ryuge,1 Satoshi Igawa,1 Masaaki Ichinoe,4 Yoshiki Murakumo,4 Makoto Saegusa,4 Noriyuki Masuda1 1Department of Respiratory Medicine, School of Medicine, 2Department of Molecular Diagnostics, School of Allied Health Sciences, 3Department of Applied Tumor Pathology, Graduate School of Medical Sciences, 4Department of Pathology, School of Medicine, Kitasato University, Minami-ku, Sagamihara, Kanagawa, Japan Purpose: Although cisplatin-based adjuvant chemotherapy improves the survival of patients with resected non-small-cell lung cancer, not all patients show a survival benefit, and some patients experience severe toxicity. Therefore, identifying biomarkers is important for selecting subgroups of patients who may show improved survival with platinum-based adjuvant chemotherapy. S100A16 is thought to play key roles during different steps of tumor progression. The aim of this study was to evaluate the use of S100A16 expression as a prognostic marker in patients with completely resected lung adenocarcinoma receiving platinum-based adjuvant chemotherapy. Methods: S100A16 expression was immunohistochemically studied in 65 consecutive lung adenocarcinoma patients who underwent complete resection and received platinum-based adjuvant chemotherapy. Kaplan–Meier survival analysis and Cox proportional hazards models were used to estimate the effect of S100A16 expression on disease-free survival (DFS) and overall survival (OS).Results: S100A16 expression was detected in 26 of the 65 (40.0%) lung adenocarcinoma patients. Although S100A16 expression was not correlated with DFS (P=0.062), it was significantly correlated with OS (P=0.009). In addition, multivariable analysis revealed that S100A16 expression independently predicted a poorer survival (HR =4.79; 95% CI =1.87–12.23; P=0.001). Conclusion: The present study revealed that S100A16 is a promising candidate as a prognostic marker for platinum-based adjuvant chemotherapy in resected lung adenocarcinoma. A further large-scale study is needed to confirm the present results. Keywords: S100A16, lung adenocarcinoma, platinum-based adjuvant chemotherapy, immunohistochemistry, prognostic marker

Published
2017

16. Design and performance of the field cage for the XENONnT experiment

Author

Aprile, E., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Chávez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., DÁndrea, V., Decowski, M. P., Di Gangi, P., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Plante, G., Pollmann, T. R., Qi, J., Qin, J., García, D. Ramírez, Šarčević, N., Shi, J., Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The precision in reconstructing events detected in a dual-phase time projection chamber depends on an homogeneous and well understood electric field within the liquid target. In the XENONnT TPC the field homogeneity is achieved through a double-array field cage, consisting of two nested arrays of field shaping rings connected by an easily accessible resistor chain. Rather than being connected to the gate electrode, the topmost field shaping ring is independently biased, adding a degree of freedom to tune the electric field during operation. Two-dimensional finite element simulations were used to optimize the field cage, as well as its operation. Simulation results were compared to ${}^{83m}\mathrm{Kr}$ calibration data. This comparison indicates an accumulation of charge on the panels of the TPC which is constant over time, as no evolution of the reconstructed position distribution of events is observed. The simulated electric field was then used to correct the charge signal for the field dependence of the charge yield. This correction resolves the inconsistent measurement of the drift electron lifetime when using different calibrations sources and different field cage tuning voltages.

Published
2023
Full Text
View/download PDF

17. The effect of vitreomacular and cataract surgery on oxygen saturation in retinal vessels

Author

Nakano Y, Manabe K, Osaka R, Takasago Y, Ono A, Kobayashi M, Fujita T, Shiragami C, Hirooka K, and Tsujikawa A

Subjects
Oxygen saturation, vitrectomy, vitreomacular disease, retinal vessels, Ophthalmology, RE1-994
Abstract

Yuki Nakano, Koichiro Manabe, Rie Osaka, Yukari Takasago, Aoi Ono, Mamoru Kobayashi, Tomoyoshi Fujita, Chieko Shiragami, Kazuyuki Hirooka, Akitaka Tsujikawa Department of Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan Purpose: To evaluate the effects of vitreomacular and cataract surgery on retinal oximetry in vitreomacular disease.Patients and methods: Thirty-eight eyes with epiretinal membrane (ERM) and 15 with idiopathic macular hole (MH) underwent 25 gauge pars plana vitrectomy combined with cataract surgery and intraocular lens implantation. Retinal oximetry was performed using the Oxymap T1 before, 1 month, and 6 months after surgery. Oxymap T1 simultaneously captures monochrome images of the fundus at two different wavelengths of light. Built-in Oxymap Analyzer software measures the oxygen saturation and vessel diameter.Results: Mean arterial oxygen saturation significantly increased from 96.8%±6.2% to 100.2%± 5.8% at 1 month and to 99.6%±5.8% at 6 months after surgery (P

Published
2017

18. Searching for universality of dineutron correlation at the surface of Borromean nuclei

Author

Corsi, A., Kubota, Y., Casal, J., Gomez-Ramos, M., Moro, A. M., Authelet, G., Baba, H., Caesar, C., Calvet, D., Delbart, A., Dozono, M., Feng, J., Flavigny, F., Gheller, J. -M., Gibelin, J., Giganon, A., Gillibert, A., Hasegawa, K., Isobe, T., Kanaya, Y., Kawakami, S., Kim, D., Kiyokawa, Y., Kobayashi, M., Kobayashi, N., Kobayashi, T., Kondo, Y., Korkulu, Z., Koyama, S., Lapoux, V., Maeda, Y., Marqués, F. M., Motobayashi, T., Miyazaki, T., Nakamura, T., Nakatsuka, N., Nishio, Y., Obertelli, A., Ohkura, A., Orr, N. A., Ota, S., Otsu, H., Ozaki, T., Panin, V., Paschalis, S., Pollacco, E. C., Reichert, S., Rousse, J. -Y., Saito, A. T., Sakaguchi, S., Sako, M., Santamaria, C., Sasano, M., Sato, H., Shikata, M., Shimizu, Y., Shindo, Y., Stuhl, L., Sumikama, T., Sun, Y. L., Tabata, M., Togano, Y., Tsubota, J., Uesaka, T., Yang, Z. H., Yasuda, J., Yoneda, K., and Zenihiro, J.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The dineutron correlation is systematically studied in three different Borromean nuclei near the neutron dripline, 11Li, 14Be and 17B, via the (p, pn) knockout reaction measured at the RIBF facility in RIKEN. For the three nuclei, the correlation angle between the valence neutrons is found to be largest in the same range of intrinsic momenta, which can be associated to the nuclear surface. This result reinforces the prediction that the formation of the dineutron is universal in environments with low neutron density, such as the surface of neutron-rich Borromean nuclei.

Published
2023
Full Text
View/download PDF

19. Cosmogenic background simulations for the DARWIN observatory at different underground locations

Author

Adrover, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antunovic, B., Aprile, E., Babicz, M., Bajpai, D., Barberio, E., Baudis, L., Bazyk, M., Bell, N., Bellagamba, L., Biondi, R., Biondi, Y., Bismark, A., Boehm, C., Breskin, A., Brookes, E. J., Brown, A., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Chauvin, A., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., D'Andrea, V., Decowski, M. P., Deisting, A., Di Gangi, P., Diglio, S., Doerenkamp, M., Drexlin, G., Eitel, K., Elykov, A., Engel, R., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Garroum, N., Ghosh, S., Girard, F., Glade-Beucke, R., Glück, F., Grandi, L., Grigat, J., Größle, R., Guan, H., Guida, M., Hammann, R., Hannen, V., Hansmann-Menzemer, S., Hargittai, N., Hasegawa, T., Hils, C., Higuera, A., Hiraoka, K., Hoetzsch, L., Iacovacci, M., Itow, Y., Jakob, J., Jörg, F., Kara, M., Kavrigin, P., Kazama, S., Keller, M., Kilminster, B., Kleifges, M., Kobayashi, M., Kopec, A., von Krosigk, B., Kuger, F., Landsman, H., Lang, R. F., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Lombardi, F., Loizeau, J., Luce, T., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Undagoitia, T. Marrodán, Lopes, J. A. M., Marignetti, F., Martens, K., Masbou, J., Mastroianni, S., Milutinovic, S., Miuchi, K., Miyata, R., Molinario, A., Monteiro, C. M. B., Morå, K., Morteau, E., Mosbacher, Y., Müller, J., Murra, M., Newstead, J. L., Ni, K., Oberlack, U. G., Ostrovskiy, I., Paetsch, B., Pandurovic, M., Pellegrini, Q., Peres, R., Pienaar, J., Pierre, M., Piotter, M., Plante, G., Pollmann, T. R., Principe, L., Qi, J., Qin, J., Silva, M. Rajado, García, D. Ramírez, Razeto, A., Sakamoto, S., Sanchez, L., Sanchez-Lucas, P., Santos, J. M. F. dos, Sartorelli, G., Scaffidi, A., Schulte, P., Schultz-Coulon, H. -C., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Sharma, S., Shen, W., Silva, M., Simgen, H., Singh, R., Solmaz, M., Stanley, O., Steidl, M., Tan, P. L., Terliuk, A., Thers, D., Thümmler, T., Tönnies, F., Toschi, F., Trinchero, G., Trotta, R., Tunnell, C., Urquijo, P., Valerius, K., Vecchi, S., Vetter, S., Volta, G., Vorkapic, D., Wang, W., Weerman, K. M., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, J., Wolf, T., Wu, V. H. S., Wurm, M., Xing, Y., Yamashita, M., Ye, J., Zavattini, G., and Zuber, K.

Subjects
Physics - Instrumentation and Detectors
Abstract

Xenon dual-phase time projections chambers (TPCs) have proven to be a successful technology in studying physical phenomena that require low-background conditions. With 40t of liquid xenon (LXe) in the TPC baseline design, DARWIN will have a high sensitivity for the detection of particle dark matter, neutrinoless double beta decay ($0\nu\beta\beta$), and axion-like particles (ALPs). Although cosmic muons are a source of background that cannot be entirely eliminated, they may be greatly diminished by placing the detector deep underground. In this study, we used Monte Carlo simulations to model the cosmogenic background expected for the DARWIN observatory at four underground laboratories: Laboratori Nazionali del Gran Sasso (LNGS), Sanford Underground Research Facility (SURF), Laboratoire Souterrain de Modane (LSM) and SNOLAB. We determine the production rates of unstable xenon isotopes and tritium due to muon-included neutron fluxes and muon-induced spallation. These are expected to represent the dominant contributions to cosmogenic backgrounds and thus the most relevant for site selection.

Published
2023
Full Text
View/download PDF

20. Search for events in XENON1T associated with Gravitational Waves

Author

XENON Collaboration, Aprile, E., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antoń, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., D'Andrea, V., Decowski, M. P., Di Gangi, P., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Carlos, D. G. Layos, Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M, Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Pellegrini, Q., Peres, R., Peters, C, Pienaar, J., Pierre, M., Plante, G., Pollmann, T. R., Qi, J., Qin, J., García, D. Ramírez, Shi, J., Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We perform a blind search for particle signals in the XENON1T dark matter detector that occur close in time to gravitational wave signals in the LIGO and Virgo observatories. No particle signal is observed in the nuclear recoil, electronic recoil, CE$\nu$NS, and S2-only channels within $\pm$ 500 seconds of observations of the gravitational wave signals GW170104, GW170729, GW170817, GW170818, and GW170823. We use this null result to constrain mono-energetic neutrinos and Beyond Standard Model particles emitted in the closest coalescence GW170817, a binary neutron star merger. We set new upper limits on the fluence (time-integrated flux) of coincident neutrinos down to 17 keV at 90% confidence level. Furthermore, we constrain the product of coincident fluence and cross section of Beyond Standard Model particles to be less than $10^{-29}$ cm$^2$/cm$^2$ in the [5.5-210] keV energy range at 90% confidence level.

Published
2023

21. The XENONnT dark matter experiment

Author

Aprile, E., Aalbers, J., Abe, K., Ahmed Maouloud, S., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Antón Martin, D., Arneodo, F., Balata, M., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cassese, F., Chiarini, A., Cichon, D., Cimental Chavez, A. P., Colijn, A. P., Conrad, J., Corrieri, R., Cuenca-García, J. J., Cussonneau, J. P., Dadoun, O., D’Andrea, V., Decowski, M. P., De Fazio, B., Gangi, P. Di, Diglio, S., Disdier, J. M., Douillet, D., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Form, S., Front, D., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Gardner, R., Garroum, N., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guerzoni, M., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Huhmann, C., Iacovacci, M., Iaquaniello, G., Iven, L., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Marrodán Undagoitia, T., Martella, P., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Mele, E., Messina, M., Michinelli, R., Miuchi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Nisi, S., Oberlack, U., Orlandi, D., Othegraven, R., Paetsch, B., Palacio, J., Parlati, S., Paschos, P., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Plante, G., Pollmann, T. R., Qi, J., Qin, J., García, D. Ramírez, Rynge, M., Shi, J., Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Eißing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Stephen, J., Stern, M., Stillwell, B. K., Takeda, A., Tan, P.-L., Tatananni, D., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Westermann, J., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Published
2024
Full Text
View/download PDF

22. Observational cohort study focused on treatment continuity of patients administered XELOX plus bevacizumab for previously untreated metastatic colorectal cancer

Author

Kotaka M, Ikeda F, Tsujie M, Yoshioka S, Nakamoto Y, Ishii T, Kyogoku T, Kato T, Tsuji A, and Kobayashi M

Subjects
Observational cohort study, metastatic colorectal cancer, XELOX plus bevacizumab, treatment continuity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Masahito Kotaka,1 Fusao Ikeda,2 Masaki Tsujie,3 Shinichi Yoshioka,4 Yoshihiko Nakamoto,5 Takaaki Ishii,6 Takahisa Kyogoku,7 Takeshi Kato,8 Akihito Tsuji,9 Michiya Kobayashi101Gastrointestinal Cancer Center, Sano Hospital, Kobe, Hyogo, 2Department of Surgery, Kohka Public Hospital, Koka, Shiga, 3Department of Colorectal Surgery, Sakai City Medical Center, Sakai, Osaka, 4Department of Surgery, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Hyogo, 5Department of Surgery, Seikei-kai Chiba Medical Center, Chiba, Chiba, 6Department of Surgery, Kobe-Ekisaikai Hospital, Kobe, Hyogo, 7Department of Surgery, Nishikobe Medical Center, Kobe, Hyogo, 8Department of Colorectal Surgery, Kansai Rosai Hospital, Amagasaki, Hyogo, 9Kagawa University Hospital Cancer Center, Kita-gun, Kagawa, 10Department of Human Health and Medical Sciences, Kochi Medical School, Kochi University, Nangoku, Kochi, JapanBackground: There has been remarkable progress in systemic chemotherapy for metastatic colorectal cancer due to the widespread use of irinotecan, oxaliplatin, anti-vascular endothelial growth factor antibody, and anti-epidermal growth factor receptor antibody. It is important to continue treatment with the optimal combination of these drugs and prolong progression-free survival (PFS) to improve overall survival (OS). We conducted a prospective observational cohort study of 40 patients treated with XELOX plus bevacizumab for previously untreated metastatic colorectal cancer to investigate treatment continuity.Patients and methods: Eligibility criteria were as follows: 1) histologically confirmed metastatic colorectal cancer; 2) lesions evaluable by imaging; 3) previously untreated; 4) suitable condition to receive XELOX plus bevacizumab; and 5) written informed consent. Outcomes were treatment continuity, overall response rate, resection rate, liver resection rate, time to treatment failure, PFS, and OS. Forty patients were enrolled and followed up for 2 years.Results: Between July 2010 and June 2012, 40 patients were enrolled. The median number of treatment cycles was 7.5, and the reasons for discontinuation of treatment were as follows: complete response (five patients), resection (ten patients), progression (15 patients), adverse events (seven patients), and patient refusal (three patients). The overall response rate was 57.5%, resection rate was 25%, and liver resection rate was 15%. After a median follow-up of 31.4 months, the median time to treatment failure, PFS, and OS were 5.3, 13.3, and 38.9 months, respectively.Conclusion: Although the median time to treatment failure was 5.3 months, the median PFS and OS were prolonged to 13.3 and 38.9 months, respectively. This may have resulted from the chemotherapy-free interval due to complete response in five patients and resection in ten patients. Keywords: observational cohort study, metastatic colorectal cancer, XELOX plus bevacizumab, treatment continuity

Published
2016

23. Changes in blood biochemical markers before, during, and after a 2-day ultramarathon

Author

Arakawa K, Hosono A, Shibata K, Ghadimi R, Fuku M, Goto C, Imaeda N, Tokudome Y, Hoshino H, Marumoto M, Kobayashi M, Suzuki S, and Tokudome S

Subjects
long-distance running, blood biochemical markers, anemia, muscle damage, lipid metabolism, inflammation, Sports medicine, RC1200-1245
Abstract

Kazuyuki Arakawa,1,2 Akihiro Hosono,2 Kiyoshi Shibata,3 Reza Ghadimi,4 Mizuho Fuku,5 Chiho Goto,6 Nahomi Imaeda,7 Yuko Tokudome,8 Hideki Hoshino,9 Mitsuhiro Marumoto,1,2 Masaaki Kobayashi,10 Sadao Suzuki,2 Shinkan Tokudome1,2,11 1Department of Health and Nutrition Policy, 2Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; 3Department of Public Health and Nutrition, Aichi Gakusen University, Okazaki, Japan; 4Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; 5Department of Rehabilitation Medicine, Yokohama Stroke and Brain Center, Yokohama, Japan; 6Department of Health and Nutrition, Nagoya Bunri University, Inazawa, Japan; 7Department of Food Science and Nutrition, Nagoya Women’s University, Nagoya, Japan; 8Department of Nutritional Sciences, Nagoya University of Arts and Sciences, Nisshin, Japan; 9Department of Early Childhood Studies, Aichi Bunkyo Women’s College, Inazawa, Japan; 10Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; 11National Institute of Health and Nutrition, Tokyo, Japan Abstract: We studied changes in blood markers of 18 nonprofessional, middle-aged runners of a 2-day, 130 km ultramarathon. Blood was sampled at baseline, after the goals on the first and second day, and at three time points (1, 3, and 5/6 days) after the race. Blood indices showed three patterns. First pattern indices showed essentially no changes after the two goals and after the race, including red blood cell indices, gamma-glutamyl transferase, and tumor necrosis factor-α. Second pattern markers, including the majority of indices, were elevated during the race (and also after the race for some parameters) and then returned to baseline afterward, including hemolysis/red blood cell destruction markers (indirect bilirubin) and an iron reservoir index (ferritin), muscle damage parameters (uric acid, creatine kinase, lactate dehydrogenase, and aspartate aminotransferase), renal function markers (creatinine and blood urea nitrogen), liver injury index (alanine aminotransferase), lipid metabolism indices (free fatty acid), reactive oxygen species and inflammation parameters (white blood cells, interleukin-6, and C-reactive protein), and energy production and catecholamines (adrenaline, noradrenaline, and dopamine). Third pattern index of a lipid metabolism marker – triglyceride – decreased during the race periods and started returning to baseline from then onward. Some hormonal markers such as insulin, leptin, and adiponectin showed unique patterns. These findings appeared informative for nonprofessional athletes to know about an optimal physical activity level, duration, and total exercise for elevating physical performance and monitoring physical/mental conditioning as well as for prevention of overtraining and physical injuries. Keywords: long-distance running, blood biochemical markers, anemia, muscle damage, lipid metabolism, inflammation

Published
2016

24. Cost-effectiveness analysis of pregabalin for treatment of chronic low back pain in patients with accompanying lower limb pain (neuropathic component) in Japan

Author

Igarashi A, Akazawa M, Murata T, Taguchi T, Sadosky A, Ebata N, Willke R, Fujii K, Doherty J, and Kobayashi M

Subjects
Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950
Abstract

Ataru Igarashi,1 Manabu Akazawa,2 Tatsunori Murata,3 Toshihiko Taguchi,4 Alesia Sadosky,5 Nozomi Ebata,6 Richard Willke,5 Koichi Fujii,6 Jim Doherty,5 Makoto Kobayashi3 1Department of Drug Policy and Management, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan; 2Department of Public Health and Epidemiology, Meiji Pharmaceutical University, Tokyo, Japan; 3CRECON Medical Assessment Inc., Tokyo, Japan; 4Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; 5Pfizer Inc., New York, NY, USA; 6Pfizer Japan, Inc., Tokyo, Japan Objective: To assess the cost-effectiveness of pregabalin for the treatment of chronic low back pain with accompanying neuropathic pain (CLBP-NeP) from the health care payer and societal perspectives. Methods: The cost-effectiveness of pregabalin versus usual care for treatment of CLBP-NeP was evaluated over a 12-month time horizon using the incremental cost-effectiveness ratio (ICER). Quality-adjusted life years (QALYs), derived from the five-dimension, five-level EuroQol (EQ-5D-5L) questionnaire, was the measure of effectiveness. Medical costs and productivity losses were both calculated. Expected costs and outcomes were estimated via cohort simulation using a state-transition model, which mimics pain state transitions among mild, moderate, and severe pain. Distributions of pain severity were obtained from an 8-week noninterventional study. Health care resource consumption for estimation of direct medical costs for pain severity levels was derived from a physician survey. The ICER per additional QALY gained was calculated and sensitivity analyses were performed to evaluate the robustness of the assumptions across a range of values. Results: Direct medical costs and hospitalization costs were both lower in the pregabalin arm compared with usual care. The estimated ICERs in the base case scenarios were approximately ¥2,025,000 and ¥1,435,000 per QALY gained with pregabalin from the payer and societal perspectives, respectively; the latter included indirect costs related to lost productivity. Sensitivity analyses using alternate values for postsurgical pain scores (0 and 5), initial pain severity levels (either all moderate or all severe), and the actual EQ-5D-5L scores from the noninterventional study showed robustness of results, with ICERs that were similar to the base case. Development of a cost-effectiveness acceptability curve showed high probability (≥75%) of pregabalin being cost-effective. Conclusion: Using data and assumptions from routine clinical practice, pregabalin is cost-effective for the treatment of CLBP-NeP in Japan. Keywords: usual care, neuropathic pain, Markov model, quality-adjusted life-year, willingness to pay, health economics

Published
2015

25. Giant molecular clouds and their Type classification in M74: Toward understanding star formation and cloud evolution

Author

Demachi, F., Fukui, Y., Yamada, R. I., Tachihara, K., Hayakawa, T., Tokuda, K., Fujita, S., Kobayashi, M. I. N., Muraoka, K., Konishi, A., Tsuge, K., Onishi, T., and Kawamura, A.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We investigated the giant molecular clouds (GMCs) in M74 (NGC 628), using data obtained from the PHANGS project. We applied the GMC Types according to the activity of star formation: Type I without star formation, Type II with H$\alpha$ luminosity ($L_\mathrm{H\alpha}$) less than $10^{37.5}~\mathrm{erg~s^{-1}}$, and Type III with $L_\mathrm{H\alpha}$ greater than $10^{37.5}~\mathrm{erg~s^{-1}}$. A total of 432 GMCs were identified, with 59, 201, and 172 GMCs, for Type I, II, and III, respectively. The size and mass of the GMCs range from 23 to 238 pc and $10^{4.9}$ to $10^{7.1}$ M$_{\odot}$, indicating that the mass and radius increase from Type I to III. Clusters younger than 4 Myr and HII regions are concentrated within 150 pc of a GMC, indicating a tight association between these young objects and GMCs. The virial ratio decreases from Type I to Type III, indicating that Type III GMCs are the most gravitationally relaxed among the three. We interpret that the GMCs evolve from Type I to Type III, as previously observed in the LMC. Based on a steady-state assumption, the estimated evolutionary timescales of Type I, II, and III are 1, 5, and 4 Myr, respectively. We assume that the timescale of Type III is equal to the age of the associated clusters, indicating a GMC lifetime of 10 Myr or longer. Although Chevance et al. (2020, MNRAS, 493, 2872) investigated GMCs using the same PHANGS dataset of M74, they did not define a GMC, reaching an evolutionary picture with a 20 Myr duration of the non-star-forming phase, which was five times longer than 4 Myr. We compare the present results with those of Chevance et al. (2020) and argue that defining individual GMCs is essential for understanding GMC evolution., Comment: 30 pages, 34 figures, 7 tables

Published
2023
Full Text
View/download PDF

26. Searching for Heavy Dark Matter near the Planck Mass with XENON1T

Author

Aprile, E., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Chavez, A. P. Cimental, Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Pollmann, T. R., Qi, J., Qin, J., García, D. Ramírez, Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

Multiple viable theoretical models predict heavy dark matter particles with a mass close to the Planck mass, a range relatively unexplored by current experimental measurements. We use 219.4 days of data collected with the XENON1T experiment to conduct a blind search for signals from Multiply-Interacting Massive Particles (MIMPs). Their unique track signature allows a targeted analysis with only 0.05 expected background events from muons. Following unblinding, we observe no signal candidate events. This work places strong constraints on spin-independent interactions of dark matter particles with a mass between 1$\times$10$^{12}\,$GeV/c$^2$ and 2$\times$10$^{17}\,$GeV/c$^2$. In addition, we present the first exclusion limits on spin-dependent MIMP-neutron and MIMP-proton cross-sections for dark matter particles with masses close to the Planck scale., Comment: 7 pages, 6 figures

Published
2023
Full Text
View/download PDF

27. Detector signal characterization with a Bayesian network in XENONnT

Author

XENON Collaboration, Aprile, E., Abe, K., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Pellegrini, Q., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Pollmann, T. R., Qi, J., Qin, J., García, D. Ramírez, Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment
Abstract

We developed a detector signal characterization model based on a Bayesian network trained on the waveform attributes generated by a dual-phase xenon time projection chamber. By performing inference on the model, we produced a quantitative metric of signal characterization and demonstrate that this metric can be used to determine whether a detector signal is sourced from a scintillation or an ionization process. We describe the method and its performance on electronic-recoil (ER) data taken during the first science run of the XENONnT dark matter experiment. We demonstrate the first use of a Bayesian network in a waveform-based analysis of detector signals. This method resulted in a 3% increase in ER event-selection efficiency with a simultaneously effective rejection of events outside of the region of interest. The findings of this analysis are consistent with the previous analysis from XENONnT, namely a background-only fit of the ER data., Comment: 11 pages, 8 figures

Published
2023
Full Text
View/download PDF

28. First Dark Matter Search with Nuclear Recoils from the XENONnT Experiment

Author

XENON Collaboration, Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bazyk, M., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Chavez, A. P. Cimental, Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guan, H., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Singh, R., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Wu, V. H. S., Xing, Y., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

We report on the first search for nuclear recoils from dark matter in the form of weakly interacting massive particles (WIMPs) with the XENONnT experiment which is based on a two-phase time projection chamber with a sensitive liquid xenon mass of $5.9$ t. During the approximately 1.1 tonne-year exposure used for this search, the intrinsic $^{85}$Kr and $^{222}$Rn concentrations in the liquid target were reduced to unprecedentedly low levels, giving an electronic recoil background rate of $(15.8\pm1.3)~\mathrm{events}/(\mathrm{t\cdot y \cdot keV})$ in the region of interest. A blind analysis of nuclear recoil events with energies between $3.3$ keV and $60.5$ keV finds no significant excess. This leads to a minimum upper limit on the spin-independent WIMP-nucleon cross section of $2.58\times 10^{-47}~\mathrm{cm}^2$ for a WIMP mass of $28~\mathrm{GeV}/c^2$ at $90\%$ confidence level. Limits for spin-dependent interactions are also provided. Both the limit and the sensitivity for the full range of WIMP masses analyzed here improve on previous results obtained with the XENON1T experiment for the same exposure., Comment: Limit points are included in the submission file

Published
2023
Full Text
View/download PDF

29. Oxygen on-site Coulomb energy in Pr$_{1.3-x}$La$_{0.7}$Ce$_x$CuO$_{4}$ and Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$ and its relation with Heisenberg exchange

Author

Chainani, A., Horio, M., Cheng, C. -M., Malterre, D., Sheshadri, K., Kobayashi, M., Horiba, K., Kumigashira, H., Mizokawa, T., Oura, M., Taguchi, M., Mori, Y., Takahashi, A., Konno, T., Ohgi, T., Sato, H., Adachi, T., Koike, Y., Mochiku, T., Hirata, K., Shin, S., Wu, M. K., and Fujimori, A.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

We study the electronic structure of electron-doped Pr$_{1.3-x}$La$_{0.7}$Ce$_{x}$CuO$_{4}$ (PLCCO ; $T_{c}$ = 27 K, x = 0.1) and hole-doped Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$ (Bi2212 ; $T_{c}$ = 90 K) cuprate superconductors using x-ray absorption spectroscopy (XAS) and resonant photoemission spectroscopy (Res-PES). From Res-PES across the O K-edge and Cu L-edge, we identify the O 2p and Cu 3d partial density of states (PDOS) and their correlation satellites which originate in two-hole Auger final states. Using the Cini-Sawatzky method, analysis of the experimental O 2p PDOS shows an oxygen on-site Coulomb energy for PLCCO to be $U_{p}$ = 3.3$\pm$0.5 eV and for Bi2212, $U_{p}$ = 5.6$\pm$0.5 eV, while the copper on-site Coulomb correlation energy, $U_{d}$ = 6.5$\pm$0.5 eV for Bi2212. The expression for the Heisenberg exchange interaction $J$ in terms of the electronic parameters $U_{d}$, $U_{p}$, charge-transfer energy $\Delta$ and Cu-O hopping $t_{pd}$ obtained from a simple Cu$_2$O cluster model is used to carry out an optimization analysis consistent with $J$ known from scattering experiments. The analysis also provides the effective one band on-site Coulomb correlation energy $\tilde{U}$ and the effective hopping $\tilde{t}$. PLCCO and Bi2212 are shown to exhibit very similar values of $\tilde{U}$/$\tilde{t}$ $\sim$9-10, confirming the strongly correlated nature of the singlet ground state in the effective one-band model for both the materials., Comment: 13, pages, 11 figures

Published
2023
Full Text
View/download PDF

30. Applicability assessment of ceramic microbeads coated with hydroxyapatite-binding silver/titanium dioxide ceramic composite earthplus™ to the eradication of Legionella in rainwater storage tanks for household use

Author

Oana K, Kobayashi M, Yamaki D, Sakurada T, Nagano N, and Kawakami Y

Subjects
Medicine (General), R5-920
Abstract

Kozue Oana,1,2 Michiko Kobayashi,1 Dai Yamaki,3 Tsukasa Sakurada,3 Noriyuki Nagano,1,2 Yoshiyuki Kawakami1,2 1Division of Infection Control and Microbiological Regulation, Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine, 2Division of Clinical Microbiology, Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University School of Medicine, Matsumoto, 3Shinshu Ceramics Co., Ltd., Kiso, Nagano, Japan Abstract: Water environments appear to be the habitats of Legionella species. Legionellosis is considered as a preventable illness because bacterial reservoirs can be controlled and removed. Roof-harvested rainwater has attracted significant attention not only as a groundwater recharge but also as a potential alternative source of nonpotable water. We successfully developed ceramic microbeads coated with hydroxyapatite-binding silver/titanium dioxide ceramic composite earthplus™ using the thermal spraying method. The ceramic microbeads were demonstrated to have bactericidal activities against not only Legionella but also coliform and heterotrophic bacteria. Immersing the ceramic microbeads in household rainwater storage tanks was demonstrated to yield the favorable eradication of Legionella organisms. Not only rapid-acting but also long-lasting bactericidal activities of the ceramic microbead were exhibited against Legionella pneumophila. However, time-dependent attenuation of the bactericidal activities against Legionella were also noted in the sustainability appraisal experiment. Therefore, the problems to be overcome surely remain in constantly managing the Legionella-pollution by means of immersing the ceramic microbeads. The results of our investigation apparently indicate that the earthplus™-coated ceramic microbeads would become the favorable tool for Legionella measures in household rainwater storage tanks, which may become the natural reservoir for Legionella species. Our investigation would justify further research and data collection to obtain more reliable procedures to microbiologically regulate the Legionella in rainwater storage tanks. Keywords: hydroxyapatite, silver, TiO2, earthplus™, ceramic, Legionella, eradication, rainwater storage tank

Published
2015

31. Anisotropic Enhancement of Lower Critical Field in Ultraclean Crystals of Spin-Triplet Superconductor UTe2

Author

Ishihara, K., Kobayashi, M., Imamura, K., Konczykowski, M., Sakai, H., Opletal, P., Tokiwa, Y., Haga, Y., Hashimoto, K., and Shibauchi, T.

Subjects
Condensed Matter - Superconductivity
Abstract

The paramagnetic spin-triplet superconductor UTe$_2$ has attracted significant attention because of its exotic superconducting properties including an extremely high upper critical field and possible chiral superconducting states. Recently, ultraclean single crystals of UTe$_2$ have become available, and thus measurements on these crystals are crucial to elucidate the intrinsic superconducting properties. Here, we report the thermodynamic critical field $H_{\rm c}$, the lower critical field $H_{\rm c1}$, and the upper critical field $H_{\rm c2}$ at low fields of these high-quality single crystals. From the comparison of the anisotropies in $H_{\rm c1}$ and $H_{\rm c2}$, we find that the experimental $H_{\rm c1}$ values with the magnetic field along $b$- and $c$-axes are anomalously enhanced, showing unusual low-temperature upturns. We propose an effect of the strong Ising-like ferromagnetic fluctuations on the vortex line energy as the origin of the anisotropic enhancement of $H_{\rm c1}$., Comment: 7 pages, 6 figures

Published
2023
Full Text
View/download PDF

32. Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir

Author

Suzuki F, Sezaki H, Akuta N, Suzuki Y, Kawamura Y, Hosaka T, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Watahiki S, Mineta R, and Kumada H

Subjects
Therapeutics. Pharmacology, RM1-950
Abstract

Fumitaka Suzuki,1,2 Hitomi Sezaki,1 Norio Akuta,1 Yoshiyuki Suzuki,1 Yusuke Kawamura,1 Tetsuya Hosaka,1 Masahiro Kobayashi,1 Satoshi Saitoh,1 Yasuji Arase,1 Kenji Ikeda,1 Mariko Kobayashi,3 Sachiyo Watahiki,3 Rie Mineta,3 Yukiko Suzuki,3 Hiromitsu Kumada1 1Department of Hepatology, Toranomon Hospital, Tokyo, Japan; 2Okinaka Memorial Institute for Medical Research, Tokyo, Japan; 3Research Institute for Hepatology, Toranomon Branch Hospital, Kawasaki, Japan Abstract: Tenofovir disoproxil fumarate (TDF) is widely used to treat hepatitis B virus (HBV) patients in the USA and Europe. No confirmed report of resistance selection during treatment with TDF in treatment-naïve and nucleoside/nucleotide analog-treated chronic hepatitis B patients has yet been reported. Here, we report for the first time a patient with chronic hepatitis B and cirrhosis who emerged with virologic breakthrough during combination therapy with TDF and entecavir (ETV), against ETV-resistant virus. A 51-year-old Japanese woman with hepatitis B e-antigen (HBeAg), whose genotype was C, received ETV monotherapy continuously followed by TDF and ETV combination therapy, because her HBV DNA levels had been >3.5 log copies/mL. At the start of combination therapy, amino acid substitutions of the reverse transcriptase (rt) gene, rtL180M, rtT184I/M, and rtM204V, were detected. After this, serum HBV DNA decreased to less than 2.1 log copies/mL and remained at this level until 31 months of combination therapy, when it again began to increase. Amino acid substitutions of rtL180M, rtS202G, and rtM204V emerged and were associated with an increase in serum HBV DNA at virologic breakthrough. Long-term therapy with TDF against the ETV-resistant virus has the potential to induce virologic breakthrough and resistance, and careful follow-up should be carried out. Keywords: hepatitis B virus, resistant

Published
2014

33. The Triggerless Data Acquisition System of the XENONnT Experiment

Author

Aprile, E., Aalbers, J., Abe, K., Agostini, F., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brookes, E. J., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Cardoso, J. M. R., Cichon, D., Chavez, A. P. Cimental, Coderre, D., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Hood, N. F., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Rocchetti, A., Sanchez, L., Sanchez-Lucas, P., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., and Zhu, T.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The XENONnT detector uses the latest and largest liquid xenon-based time projection chamber (TPC) operated by the XENON Collaboration, aimed at detecting Weakly Interacting Massive Particles and conducting other rare event searches. The XENONnT data acquisition (DAQ) system constitutes an upgraded and expanded version of the XENON1T DAQ system. For its operation, it relies predominantly on commercially available hardware accompanied by open-source and custom-developed software. The three constituent subsystems of the XENONnT detector, the TPC (main detector), muon veto, and the newly introduced neutron veto, are integrated into a single DAQ, and can be operated both independently and as a unified system. In total, the DAQ digitizes the signals of 698 photomultiplier tubes (PMTs), of which 253 from the top PMT array of the TPC are digitized twice, at $\times10$ and $\times0.5$ gain. The DAQ for the most part is a triggerless system, reading out and storing every signal that exceeds the digitization thresholds. Custom-developed software is used to process the acquired data, making it available within $\mathcal{O}\left(10\text{ s}\right)$ for live data quality monitoring and online analyses. The entire system with all the three subsystems was successfully commissioned and has been operating continuously, comfortably withstanding readout rates that exceed $\sim500$ MB/s during calibration. Livetime during normal operation exceeds $99\%$ and is $\sim90\%$ during most high-rate calibrations. The combined DAQ system has collected more than 2 PB of both calibration and science data during the commissioning of XENONnT and the first science run.

Published
2022
Full Text
View/download PDF

34. Involvement of magnitude of ambient temperature change in nonspecific effect in perceived placebo effect on lower urinary tract symptoms: study on switching of naftopidil in patients with benign prostatic hyperplasia

Author

Morita T, Komatsu K, Kubo T, Fujisaki A, Natsui S, Nukui A, Kobayashi M, and Kurokawa S

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Tatsuo Morita, Kenji Komatsu, Taro Kubo, Akira Fujisaki, Shinsuke Natsui, Akinori Nukui, Minoru Kobayashi, Shinsuke Kurokawa Department of Urology, Jichi Medical University, Tochigi, Japan Purpose: To determine if switching from one brand of the α1-adrenoceptor antagonist naftopidil (Avishot™) to another brand (Flivas™) under the same conditions causes the same changes in lower urinary tract symptoms (LUTS) and quality of life (QOL) as the perceived placebo effect, and if ambient temperature as a nonspecific factor is related to those changes in benign prostatic hyperplasia (BPH) patients. Patients and methods: A retrospective study was carried out on 217 BPH patients who had received Avishot™ for more than 6 months and then were switched to Flivas™ at the same dose and timing. The two drugs contain the same principal ingredient and display the same pharmacokinetic properties. The International Prostate Symptom Score (IPSS), QOL score, and average monthly ambient temperature at the patients’ residence area from the Automated Meteorological Data Acquisition System in Japan were used for the evaluation. Results: A significant change in urinary storage symptoms (P = 0.006), and especially in nighttime frequency (P < 0.001), was observed by switching drugs, suggesting the perceived placebo effect. There was significant improvement of daytime frequency (P < 0.05), nighttime frequency (P < 0.001), storage symptoms (P < 0.001), and total IPSS (P < 0.05) when the magnitude of ambient temperature change from before and 3 months after switching drugs was higher than 10°C, while no significant improvement was noted in any of the parameters examined when the same was lower than 10°C. Conclusion: The present study showed the nonspecific effect of magnitude of ambient temperature change was involved in the perceived placebo effect on LUTS, especially on storage symptoms, by switching drugs. The nonspecific effect on LUTS with BPH needs to be considered when evaluating subjective treatment efficacy of drugs for LUTS with BPH in routine clinical practice. The present study supports the lifestyle advice “avoid exposing the lower body to cold temperature” or “keep warm when it is cold” for LUTS with BPH. Keywords: ambient temperature, benign prostatic hyperplasia, lower urinary tract symptoms, naftopidil, nonspecific effect, placebo effect

Published
2013

35. Low-energy Calibration of XENON1T with an Internal $^{37}$Ar Source

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Sanchez-Lucas, P., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., Zhu, T., Geppert, C., and Riemer, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

A low-energy electronic recoil calibration of XENON1T, a dual-phase xenon time projection chamber, with an internal $^{37}$Ar source was performed. This calibration source features a 35-day half-life and provides two mono-energetic lines at 2.82 keV and 0.27 keV. The photon yield and electron yield at 2.82 keV are measured to be (32.3$\pm$0.3) photons/keV and (40.6$\pm$0.5) electrons/keV, respectively, in agreement with other measurements and with NEST predictions. The electron yield at 0.27 keV is also measured and it is (68.0$^{+6.3}_{-3.7}$) electrons/keV. The $^{37}$Ar calibration confirms that the detector is well-understood in the energy region close to the detection threshold, with the 2.82 keV line reconstructed at (2.83$\pm$0.02) keV, which further validates the model used to interpret the low-energy electronic recoil excess previously reported by XENON1T. The ability to efficiently remove argon with cryogenic distillation after the calibration proves that $^{37}$Ar can be considered as a regular calibration source for multi-tonne xenon detectors.

Published
2022
Full Text
View/download PDF

36. Effective Field Theory and Inelastic Dark Matter Results from XENON1T

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

In this work, we expand on the XENON1T nuclear recoil searches to study the individual signals of dark matter interactions from operators up to dimension-eight in a Chiral Effective Field Theory (ChEFT) and a model of inelastic dark matter (iDM). We analyze data from two science runs of the XENON1T detector totaling 1\,tonne$\times$year exposure. For these analyses, we extended the region of interest from [4.9, 40.9]$\,$keV$_{\text{NR}}$ to [4.9, 54.4]$\,$keV$_{\text{NR}}$ to enhance our sensitivity for signals that peak at nonzero energies. We show that the data is consistent with the background-only hypothesis, with a small background over-fluctuation observed peaking between 20 and 50$\,$keV$_{\text{NR}}$, resulting in a maximum local discovery significance of 1.7\,$\sigma$ for the Vector$\otimes$Vector$_{\text{strange}}$ ($VV_s$) ChEFT channel for a dark matter particle of 70$\,$GeV/c$^2$, and $1.8\,\sigma$ for an iDM particle of 50$\,$GeV/c$^2$ with a mass splitting of 100$\,$keV/c$^2$. For each model, we report 90\,\% confidence level (CL) upper limits. We also report upper limits on three benchmark models of dark matter interaction using ChEFT where we investigate the effect of isospin-breaking interactions. We observe rate-driven cancellations in regions of the isospin-breaking couplings, leading to up to 6 orders of magnitude weaker upper limits with respect to the isospin-conserving case.

Published
2022

37. An approximate likelihood for nuclear recoil searches with XENON1T data

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Santos, J. M. F. dos, Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The XENON collaboration has published stringent limits on specific dark matter -nucleon recoil spectra from dark matter recoiling on the liquid xenon detector target. In this paper, we present an approximate likelihood for the XENON1T 1 tonne-year nuclear recoil search applicable to any nuclear recoil spectrum. Alongside this paper, we publish data and code to compute upper limits using the method we present. The approximate likelihood is constructed in bins of reconstructed energy, profiled along the signal expectation in each bin. This approach can be used to compute an approximate likelihood and therefore most statistical results for any nuclear recoil spectrum. Computing approximate results with this method is approximately three orders of magnitude faster than the likelihood used in the original publications of XENON1T, where limits were set for specific families of recoil spectra. Using this same method, we include toy Monte Carlo simulation-derived binwise likelihoods for the upcoming XENONnT experiment that can similarly be used to assess the sensitivity to arbitrary nuclear recoil signatures in its eventual 20 tonne-year exposure., Comment: Accepted by European Physical Journal C

Published
2022
Full Text
View/download PDF

38. Search for New Physics in Electronic Recoil Data from XENONnT

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Gardner, R., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Paschos, P., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Stephen, J., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment
Abstract

We report on a blinded analysis of low-energy electronic-recoil data from the first science run of the XENONnT dark matter experiment. Novel subsystems and the increased 5.9 tonne liquid xenon target reduced the background in the (1, 30) keV search region to $(15.8 \pm 1.3)$ events/(tonne$\times$year$\times$keV), the lowest ever achieved in a dark matter detector and $\sim$5 times lower than in XENON1T. With an exposure of 1.16 tonne-years, we observe no excess above background and set stringent new limits on solar axions, an enhanced neutrino magnetic moment, and bosonic dark matter., Comment: 10 pages, 6 figures. Data points are available in https://zenodo.org/record/7311940

Published
2022
Full Text
View/download PDF

39. A novel technique for the measurement of the avalanche fluctuations of a GEM stack using a gating foil

Author

Kobayashi, M., Yumino, K., Ogawa, T., Shoji, A., Aoki, Y., Ikematsu, K., Gros, P., Kawaguchi, T., Arai, D., Iwamura, M., Katsuki, K., Koto, A., Yoshikai, M., Fujii, K., Fusayasu, T., Kato, Y., Kawada, S., Matsuda, T., Mizuno, T., Nakajima, J., Narita, S., Negishi, K., Qi, H., Settles, R. D., Sugiyama, A., Takahashi, T., Tian, J., Watanabe, T., and Yonamine, R.

Subjects
Physics - Instrumentation and Detectors
Abstract

We have developed a novel technique for the measurement of the size of avalanche fluctuations of gaseous detectors using a gating device (gating foil) prepared for the time projection chamber in the international linear collider experiment (ILD-TPC). In addition to the gating function, the gating foil is capable of controlling the average fraction of drift electrons detected after gas amplification. The signal charge width and shape (skewness) for electron-ion pairs created by a pulsed UV laser as a function of the transmission rate of the gating foil can be used to determine the relative variance of gas gain for single electrons. We present the measurement principle and the result obtained using a stack of gas electron multipliers (GEMs) operated in a gas mixture of Ar-CF$_4$(3%)-isobutane(2%) at atmospheric pressure. Also discussed is the influence of the avalanche fluctuations on the spatial resolution of the ILD-TPC., Comment: 39 pages including 11 figures

Published
2022
Full Text
View/download PDF

40. Search for neutrinoless quadruple beta decay of $^{136}$Xe in XMASS-I

Author

XMASS Collaboration, Abe, K., Hiraide, K., Ichimura, K., Kato, N., Kishimoto, Y., Kobayashi, K., Kobayashi, M., Moriyama, S., Nakahata, M., Sato, K., Sekiya, H., Suzuki, T., Takeda, A., Tasaka, S., Yamashita, M., Yang, B. S., Kim, N. Y., Kim, Y. D., Kim, Y. H., Ishii, R., Itow, Y., Kanzawa, K., Masuda, K., Martens, K., Mason, A., Suzuki, Y., Miuchi, K., Takeuchi, Y., Lee, K. B., Lee, M. K., Fukuda, Y., Ogawa, H., Nishijima, K., Fushimi, K., Xu, B. D., and Nakamura, S.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

A search for the neutrinoless quadruple beta decay of $^{136}$Xe was conducted with the liquid-xenon detector XMASS-I using $\rm 327\; kg \times 800.0 \; days$ of the exposure. The pulse shape discrimination based on the scintillation decay time constant which distinguishes $\gamma$-rays including the signal and $\beta$-rays was used to enhance the search sensitivity. No significant signal excess was observed from the energy spectrum fitting with precise background evaluation, and we set a lower limit of the half life of 3.7 $\times$ 10$^{24}$ years at 90$\%$ confidence level. This is the first experimental constraint of the neutrinoless quadruple beta decay of $^{136}$Xe.

Published
2022
Full Text
View/download PDF

41. Double-Weak Decays of $^{124}$Xe and $^{136}$Xe in the XENON1T and XENONnT Experiments

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Rosso, A. Gallo, Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., and Zhu, T.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

We present results on the search for double-electron capture ($2\nu\text{ECEC}$) of $^{124}$Xe and neutrinoless double-$\beta$ decay ($0\nu\beta\beta$) of $^{136}$Xe in XENON1T. We consider captures from the K- up to the N-shell in the $2\nu\text{ECEC}$ signal model and measure a total half-life of $T_{1/2}^{2\nu\text{ECEC}}=(1.1\pm0.2_\text{stat}\pm0.1_\text{sys})\times 10^{22}\;\text{yr}$ with a $0.87\;\text{kg}\times\text{yr}$ isotope exposure. The statistical significance of the signal is $7.0\,\sigma$. We use XENON1T data with $36.16\;\text{kg}\times\text{yr}$ of $^{136}$Xe exposure to search for $0\nu\beta\beta$. We find no evidence of a signal and set a lower limit on the half-life of $T_{1/2}^{0\nu\beta\beta} > 1.2 \times 10^{24}\;\text{yr}\; \text{at}\; 90\,\%\;\text{CL}$. This is the best result from a dark matter detector without an enriched target to date. We also report projections on the sensitivity of XENONnT to $0\nu\beta\beta$. Assuming a $275\;\text{kg}\times\text{yr}$ $^{136}$Xe exposure, the expected sensitivity is $T_{1/2}^{0\nu\beta\beta} > 2.1 \times 10^{25}\;\text{yr}\; \text{at}\; 90\,\%\;\text{CL}$, corresponding to an effective Majorana mass range of $\langle m_{\beta\beta} \rangle < (0.19 - 0.59)\;\text{eV/c}^2$., Comment: 23 pages, 14 figures, 9 tables, version accepted for publication in Phys. Rev. C

Published
2022
Full Text
View/download PDF

42. Investigation of $K^+K^-$ pairs in the effective mass region near $2m_K$

Author

Adeva, B., Afanasyev, L., Anania, A., Aogaki, S., Benelli, A., Brekhovskikh, V., Cechak, T., Chiba, M., Chliapnikov, P., Drijard, D., Dudarev, A., Dumitriu, D., Federicova, P., Gorin, A., Gritsay, K., Guaraldo, C., Gugiu, M., Hansroul, M., Hons, Z., Horikawa, S., Iwashita, Y., Karpukhin, V., Kluson, J., Kobayashi, M., Kruglova, L., Kulikov, A., Kulish, E., Lamberto, A., Lanaro, A., Lednicky, R., Mariñas, C., Martincik, J., Nemenov, L., Nikitin, M., Okada, K., Olchevskii, V., Pentia, M., Penzo, A., Plo, M., Prusa, P., Rappazzo, G., Vidal, A. Romero, Ryazantsev, A., Rykalin, V., Saborido, J., Schacher, J., Sidorov, A., Smolik, J., Takeutchi, F., Trojek, T., Trusov, S., Urban, T., Vrba, T., Yazkov, V., Yoshimura, Y., and Zrelov, P.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The DIRAC experiment at CERN investigated in the reaction $\rm{p}(24~\rm{GeV}/c) + Ni$ the particle pairs $K^+K^-, \pi^+ \pi^-$ and $p \bar{p}$ with relative momentum $Q$ in the pair system less than 100 MeV/c. Because of background influence studies, DIRAC explored three subsamples of $K^+K^-$ pairs, obtained by subtracting -- using time-of-flight (TOF) technique -- background from initial $Q$ distributions with $K^+K^-$ sample fractions more than 70\%, 50\% and 30\%. The corresponding pair distributions in $Q$ and in its longitudinal projection $Q_L$ were analyzed first in a Coulomb model, which takes into account only Coulomb final state interaction (FSI) and assuming point-like pair production. This Coulomb model analysis leads to a $K^+K^-$ yield increase of about four at $Q_L=0.5$ MeV/c compared to 100 MeV/c. In order to study contributions from strong interaction, a second more sophisticated model was applied, considering besides Coulomb FSI also strong FSI via the resonances $f_0(980)$ and $a_0(980)$ and a variable distance $r^*$ between the produced $K$ mesons. This analysis was based on three different parameter sets for the pair production. For the 70\% subsample and with best parameters, $3680\pm 370$ $K^+K^-$ pairs was found to be compared to $3900\pm 410$ $K^+K^-$ extracted by means of the Coulomb model. Knowing the efficiency of the TOF cut for background suppression, the total number of detected $K^+K^-$ pairs was evaluated to be around $40000\pm 10\%$, which agrees with the result from the 30\% subsample. The $K^+K^-$ pair number in the 50\% subsample differs from the two other values by about three standard deviations, confirming -- as discussed in the paper -- that experimental data in this subsample is less reliable.

Published
2022
Full Text
View/download PDF

43. Rhombic Fermi surfaces in a ferromagnetic MnGa thin film with perpendicular magnetic anisotropy

Author

Kobayashi, M., Khang, N. H. D., Takeda, T., Araki, K., Okano, R., Suzuki, M., Kuroda, K., Yaji, K., Sugawara, K., Souma, S., Nakayama, K., Yamauchi, K., Kitamura, M., Horiba, K., Fujimori, A., Sato, T., Shin, S., Tanaka, M., and Hai, P. N.

Subjects
Condensed Matter - Materials Science
Abstract

Mn$_{1-x}$Ga$_x$ (MnGa) with the $L1_0$ structure is a ferromagnetic material with strong perpendicular magneto-crystalline anisotropy. Although MnGa thin films have been successfully grown epitaxially and studied for various spintronics devices, fundamental understandings of its electronic structure are still lacking. To address this issue, we have investigated $L1_0$-MnGa thin films using angle-resolved photoemission spectroscopy (ARPES). We have observed a large Fermi surface with a rhombic shape in the $k_x$-$k_y$ plane overlapping neighboring Fermi surfaces. The $k_z$ dependence of the band structure suggests that the band dispersion observed by ARPES comes from the three-dimensional band structure of MnGa folded by a $\sqrt{2} \times \sqrt{2}$ reconstruction. The band dispersion across the corner of the rhombic Fermi surface forms an electron pocket with a weak $k_z$ dependence. The effective mass and the mobility of the bands crossing the Fermi level near the corner are estimated from the ARPES images. Based on the experimental findings, the relationship between the observed band structure and the spin-dependent properties in MnGa-based heterostructures is discussed., Comment: 20 pages, 7 figures

Published
2022
Full Text
View/download PDF

44. A Next-Generation Liquid Xenon Observatory for Dark Matter and Neutrino Physics

Author

Aalbers, J., Abe, K., Aerne, V., Agostini, F., Maouloud, S. Ahmed, Akerib, D. S., Akimov, D. Yu., Akshat, J., Musalhi, A. K. Al, Alder, F., Alsum, S. K., Althueser, L., Amarasinghe, C. S., Amaro, F. D., Ames, A., Anderson, T. J., Andrieu, B., Angelides, N., Angelino, E., Angevaare, J., Antochi, V. C., Martin, D. Antón, Antunovic, B., Aprile, E., Araújo, H. M., Armstrong, J. E., Arneodo, F., Arthurs, M., Asadi, P., Baek, S., Bai, X., Bajpai, D., Baker, A., Balajthy, J., Balashov, S., Balzer, M., Bandyopadhyay, A., Bang, J., Barberio, E., Bargemann, J. W., Baudis, L., Bauer, D., Baur, D., Baxter, A., Baxter, A. L., Bazyk, M., Beattie, K., Behrens, J., Bell, N. F., Bellagamba, L., Beltrame, P., Benabderrahmane, M., Bernard, E. P., Bertone, G. F., Bhattacharjee, P., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Binau, A. R., Biondi, R., Biondi, Y., Birch, H. J., Bishara, F., Bismark, A., Blanco, C., Blockinger, G. M., Bodnia, E., Boehm, C., Bolozdynya, A. I., Bolton, P. D., Bottaro, S., Bourgeois, C., Boxer, B., Brás, P., Breskin, A., Breur, P. A., Brew, C. A. J., Brod, J., Brookes, E., Brown, A., Brown, E., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Burdin, S., Buse, S., Busenitz, J. K., Buttazzo, D., Buuck, M., Buzulutskov, A., Cabrita, R., Cai, C., Cai, D., Capelli, C., Cardoso, J. M. R., Carmona-Benitez, M. C., Cascella, M., Catena, R., Chakraborty, S., Chan, C., Chang, S., Chauvin, A., Chawla, A., Chen, H., Chepel, V., Chott, N. I., Cichon, D., Chavez, A. Cimental, Cimmino, B., Clark, M., Co, R. T., Colijn, A. P., Conrad, J., Converse, M. V., Costa, M., Cottle, A., Cox, G., Creaner, O., Garcia, J. J. Cuenca, Cussonneau, J. P., Cutter, J. E., Dahl, C. E., D'Andrea, V., David, A., Decowski, M. P., Dent, J. B., Deppisch, F. F., de Viveiros, L., Di Gangi, P., Di Giovanni, A., Di Pede, S., Dierle, J., Diglio, S., Dobson, J. E. Y., Doerenkamp, M., Douillet, D., Drexlin, G., Druszkiewicz, E., Dunsky, D., Eitel, K., Elykov, A., Emken, T., Engel, R., Eriksen, S. R., Fairbairn, M., Fan, A., Fan, J. J., Farrell, S. J., Fayer, S., Fearon, N. M., Ferella, A., Ferrari, C., Fieguth, A., Fiorucci, S., Fischer, H., Flaecher, H., Flierman, M., Florek, T., Foot, R., Fox, P. J., Franceschini, R., Fraser, E. D., Frenk, C. S., Frohlich, S., Fruth, T., Fulgione, W., Fuselli, C., Gaemers, P., Gaior, R., Gaitskell, R. J., Galloway, M., Gao, F., Garcia, I. Garcia, Genovesi, J., Ghag, C., Ghosh, S., Gibson, E., Gil, W., Giovagnoli, D., Girard, F., Glade-Beucke, R., Glück, F., Gokhale, S., de Gouvêa, A., Gráf, L., Grandi, L., Grigat, J., Grinstein, B., van der Grinten, M. G. D., Grössle, R., Guan, H., Guida, M., Gumbsheimer, R., Gwilliam, C. B., Hall, C. R., Hall, L. J., Hammann, R., Han, K., Hannen, V., Hansmann-Menzemer, S., Harata, R., Hardin, S. P., Hardy, E., Hardy, C. A., Harigaya, K., Harnik, R., Haselschwardt, S. J., Hernandez, M., Hertel, S. A., Higuera, A., Hils, C., Hochrein, S., Hoetzsch, L., Hoferichter, M., Hood, N., Hooper, D., Horn, M., Howlett, J., Huang, D. Q., Huang, Y., Hunt, D., Iacovacci, M., Iaquaniello, G., Ide, R., Ignarra, C. M., Iloglu, G., Itow, Y., Jacquet, E., Jahangir, O., Jakob, J., James, R. S., Jansen, A., Ji, W., Ji, X., Joerg, F., Johnson, J., Joy, A., Kaboth, A. C., Kamaha, A. C., Kanezaki, K., Kar, K., Kara, M., Kato, N., Kavrigin, P., Kazama, S., Keaveney, A. W., Kellerer, J., Khaitan, D., Khazov, A., Khundzakishvili, G., Khurana, I., Kilminster, B., Kleifges, M., Ko, P., Kobayashi, M., Kodroff, D., Koltmann, G., Kopec, A., Kopmann, A., Kopp, J., Korley, L., Kornoukhov, V. N., Korolkova, E. V., Kraus, H., Krauss, L. M., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Kuger, F., Kumar, J., Paredes, B. López, LaCascio, L., Laine, Q., Landsman, H., Lang, R. F., Leason, E. A., Lee, J., Leonard, D. S., Lesko, K. T., Levinson, L., Levy, C., Li, I., Li, S. C., Li, T., Liang, S., Liebenthal, C. S., Lin, J., Lin, Q., Lindemann, S., Lindner, M., Lindote, A., Linehan, R., Lippincott, W. H., Liu, X., Liu, K., Liu, J., Loizeau, J., Lombardi, F., Long, J., Lopes, M. I., Asamar, E. Lopez, Lorenzon, W., Lu, C., Luitz, S., Ma, Y., Machado, P. A. N., Macolino, C., Maeda, T., Mahlstedt, J., Majewski, P. A., Manalaysay, A., Mancuso, A., Manenti, L., Manfredini, A., Mannino, R. L., Marangou, N., March-Russell, J., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Martin, R., Martinez-Soler, I., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Mastronardi, M., Matias-Lopes, J. A., McCarthy, M. E., McFadden, N., McGinness, E., McKinsey, D. N., McLaughlin, J., McMichael, K., Meinhardt, P., Menéndez, J., Meng, Y., Messina, M., Midha, R., Milisavljevic, D., Miller, E. H., Milosevic, B., Milutinovic, S., Mitra, S. A., Miuchi, K., Mizrachi, E., Mizukoshi, K., Molinario, A., Monte, A., Monteiro, C. M. B., Monzani, M. E., Moore, J. S., Morå, K., Morad, J. A., Mendoza, J. D. Morales, Moriyama, S., Morrison, E., Morteau, E., Mosbacher, Y., Mount, B. J., Mueller, J., Murphy, A. St. J., Murra, M., Naim, D., Nakamura, S., Nash, E., Navaieelavasani, N., Naylor, A., Nedlik, C., Nelson, H. N., Neves, F., Newstead, J. L., Ni, K., Nikoleyczik, J. A., Niro, V., Oberlack, U. G., Obradovic, M., Odgers, K., O'Hare, C. A. J., Oikonomou, P., Olcina, I., Oliver-Mallory, K., Oranday, A., Orpwood, J., Ostrovskiy, I., Ozaki, K., Paetsch, B., Pal, S., Palacio, J., Palladino, K. J., Palmer, J., Panci, P., Pandurovic, M., Parlati, A., Parveen, N., Patton, S. J., Pěč, V., Pellegrini, Q., Penning, B., Pereira, G., Peres, R., Perez-Gonzalez, Y., Perry, E., Pershing, T., Petrossian-Byrne, R., Pienaar, J., Piepke, A., Pieramico, G., Pierre, M., Piotter, M., Pizella, V., Plante, G., Pollmann, T., Porzio, D., Qi, J., Qie, Y., Qin, J., Raj, N., Silva, M. Rajado, Ramanathan, K., García, D. Ramírez, Ravanis, J., Redard-Jacot, L., Redigolo, D., Reichard, S., Reichenbacher, J., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rocchetti, A., Rosenfeld, S. L., Rosero, R., Rupp, N., Rushton, T., Saha, S., Sanchez, L., Sanchez-Lucas, P., Santone, D., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Sazzad, A. B. M. R., Scheibelhut, M., Schnee, R. W., Schrank, M., Schreiner, J., Schulte, P., Schulte, D., Eissing, H. Schulze, Schumann, M., Schwemberger, T., Schwenk, A., Schwetz, T., Lavina, L. Scotto, Scovell, P. R., Sekiya, H., Selvi, M., Semenov, E., Semeria, F., Shagin, P., Shaw, S., Shi, S., Shockley, E., Shutt, T. A., Si-Ahmed, R., Silk, J. J., Silva, C., Silva, M. C., Simgen, H., Šimkovic, F., Sinev, G., Singh, R., Skulski, W., Smirnov, J., Smith, R., Solmaz, M., Solovov, V. N., Sorensen, P., Soria, J., Sparmann, T. J., Stancu, I., Steidl, M., Stevens, A., Stifter, K., Strigari, L. E., Subotic, D., Suerfu, B., Suliga, A. M., Sumner, T. J., Szabo, P., Szydagis, M., Takeda, A., Takeuchi, Y., Tan, P. -L., Taricco, C., Taylor, W. C., Temples, D. J., Terliuk, A., Terman, P. A., Thers, D., Thieme, K., Thümmler, Th., Tiedt, D. R., Timalsina, M., To, W. H., Toennies, F., Tong, Z., Toschi, F., Tovey, D. R., Tranter, J., Trask, M., Trinchero, G. C., Tripathi, M., Tronstad, D. R., Trotta, R., Tsai, Y. D., Tunnell, C. D., Turner, W. G., Ueno, R., Urquijo, P., Utku, U., Vaitkus, A., Valerius, K., Vassilev, E., Vecchi, S., Velan, V., Vetter, S., Vincent, A. C., Vittorio, L., Volta, G., von Krosigk, B., von Piechowski, M., Vorkapic, D., Wagner, C. E. M., Wang, A. M., Wang, B., Wang, Y., Wang, W., Wang, J. J., Wang, L. -T., Wang, M., Watson, J. R., Wei, Y., Weinheimer, C., Weisman, E., Weiss, M., Wenz, D., West, S. M., Whitis, T. J., Williams, M., Wilson, M. J., Winkler, D., Wittweg, C., Wolf, J., Wolf, T., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Wu, V. H. S., Wu, P., Wüstling, S., Wurm, M., Xia, Q., Xiang, X., Xing, Y., Xu, J., Xu, Z., Xu, D., Yamashita, M., Yamazaki, R., Yan, H., Yang, L., Yang, Y., Ye, J., Yeh, M., Young, I., Yu, H. B., Yu, T. T., Yuan, L., Zavattini, G., Zerbo, S., Zhang, Y., Zhong, M., Zhou, N., Zhou, X., Zhu, T., Zhu, Y., Zhuang, Y., Zopounidis, J. P., Zuber, K., and Zupan, J.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment, Nuclear Experiment
Abstract

The nature of dark matter and properties of neutrinos are among the most pressing issues in contemporary particle physics. The dual-phase xenon time-projection chamber is the leading technology to cover the available parameter space for Weakly Interacting Massive Particles (WIMPs), while featuring extensive sensitivity to many alternative dark matter candidates. These detectors can also study neutrinos through neutrinoless double-beta decay and through a variety of astrophysical sources. A next-generation xenon-based detector will therefore be a true multi-purpose observatory to significantly advance particle physics, nuclear physics, astrophysics, solar physics, and cosmology. This review article presents the science cases for such a detector., Comment: 77 pages, 40 figures, 1262 references

Published
2022
Full Text
View/download PDF

45. Cosmogenic background simulations for neutrinoless double beta decay with the DARWIN observatory at various underground sites

Author

Adrover, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antunovic, B., Aprile, E., Babicz, M., Bajpai, D., Barberio, E., Baudis, L., Bazyk, M., Bell, N., Bellagamba, L., Biondi, R., Biondi, Y., Bismark, A., Boehm, C., Breskin, A., Brookes, E. J., Brown, A., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Chauvin, A., Cimental Chavez, A. P., Colijn, A. P., Conrad, J., Cuenca-García, J. J., D’Andrea, V., Decowski, M. P., Deisting, A., Di Gangi, P., Diglio, S., Doerenkamp, M., Drexlin, G., Eitel, K., Elykov, A., Engel, R., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Flierman, M., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Garroum, N., Ghosh, S., Girard, F., Glade-Beucke, R., Glück, F., Grandi, L., Grigat, J., Größle, R., Guan, H., Guida, M., Hammann, R., Hannen, V., Hansmann-Menzemer, S., Hargittai, N., Hasegawa, T., Hils, C., Higuera, A., Hiraoka, K., Hoetzsch, L., Iacovacci, M., Itow, Y., Jakob, J., Jörg, F., Kara, M., Kavrigin, P., Kazama, S., Keller, M., Kilminster, B., Kleifges, M., Kobayashi, M., Kopec, A., von Krosigk, B., Kuger, F., Landsman, H., Lang, R. F., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Lombardi, F., Loizeau, J., Luce, T., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Marrodán Undagoitia, T., Lopes, J. A. M., Marignetti, F., Martens, K., Masbou, J., Mastroianni, S., Milutinovic, S., Miuchi, K., Miyata, R., Molinario, A., Monteiro, C. M. B., Morå, K., Morteau, E., Mosbacher, Y., Müller, J., Murra, M., Newstead, J. L., Ni, K., Oberlack, U. G., Ostrovskiy, I., Paetsch, B., Pandurovic, M., Pellegrini, Q., Peres, R., Pienaar, J., Pierre, M., Piotter, M., Plante, G., Pollmann, T. R., Principe, L., Qi, J., Qin, J., Rajado Silva, M., Ramírez García, D., Razeto, A., Sakamoto, S., Sanchez, L., Sanchez-Lucas, P., dos Santos, J. M. F., Sartorelli, G., Scaffidi, A., Schulte, P., Schultz-Coulon, H.-C., Schulze Eißing, H., Schumann, M., Scotto Lavina, L., Selvi, M., Semeria, F., Shagin, P., Sharma, S., Shen, W., Silva, M., Simgen, H., Singh, R., Solmaz, M., Stanley, O., Steidl, M., Tan, P.-L., Terliuk, A., Thers, D., Thümmler, T., Tönnies, F., Toschi, F., Trinchero, G., Trotta, R., Tunnell, C., Urquijo, P., Valerius, K., Vecchi, S., Vetter, S., Volta, G., Vorkapic, D., Wang, W., Weerman, K. M., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, J., Wolf, T., Wu, V. H. S., Wurm, M., Xing, Y., Yamashita, M., Ye, J., Zavattini, G., and Zuber, K.

Published
2024
Full Text
View/download PDF

47. A pregnant Japanese woman returning from Africa with recurrent fevers

Author

Tsukadaira A, Sekiguchi T, Ashida T, Murashita C, Itoh N, Kobayashi M, Kagoshima T, and Yamazaki Y

Subjects
Medicine (General), R5-920
Abstract

Akihiro Tsukadaira1, Tomohiro Sekiguchi1, Takashi Ashida2, Chinatsu Murashita3, Nobuo Itoh3, Mikiko Kobayashi4, Takashi Kagoshima4, Yoshitaka Yamazaki41Department of Internal Medicine, 2Department of Obstetrics and Gynecology, 3Division of Clinical Pathology, Iida Municipal Hospital, Yawatacho 438, Iida, Japan; 4Department of Internal Medicine, Suzaka Prefectural Hospital, Suzaka 1332, Suzaka, JapanAbstract: Certain clinical aspects of vivax malaria are no longer defined as benign. We present a case of vivax malaria with three relapses in a pregnant Japanese woman who had returned to Japan from the Comoros Islands in East Africa. Data on the successful delivery, examination of Duffy-blood group antigen, and microscopic findings of growing stages of Plasmodium vivax are thought to be of considerable interest.Keywords: vivax malaria, Duffy-blood group, pregnancy

Published
2011

48. Investigating Mercury's Environment with the Two-Spacecraft BepiColombo Mission

Author

Milillo, A., Fujimoto, M., Murakami, G., Benkhoff, J., Zender, J., Aizawa, S., Dósa, M., Griton, L., Heyner, D., Ho, G., Imber, S. M., Jia, X., Karlsson, T., Killen, R. M., Laurenza, M., Lindsay, S. T., McKenna-Lawlor, S., Mura, A., Raines, J. M., Rothery, D. A., André, N., Baumjohann, W., Berezhnoy, A., Bourdin, P. -A., Bunce, E. J., Califano, F., Deca, J., de la Fuente, S., Dong, C., Grava, C., Fatemi, S., Henri, P., Ivanovski, S. L., Jackson, B. V., James, M., Kallio, E., Kasaba, Y., Kilpua, E., Kobayashi, M., Langlais, B., Leblanc, F., Lhotka, C., Mangano, V., Martindale, A., Massetti, S., Masters, A., Morooka, M., Narita, Y., Oliveira, J. S., Odstrcil, D., Orsini, S., Pelizzo, M. G., Plainaki, C., Plaschke, F., Sahraoui, F., Seki, K., Slavin, J. A., Vainio, R., Wurz, P., Barabash, S., Carr, C. M., Delcourt, D., Glassmeier, K. -H., Grande, M., Hirahara, M., Huovelin, J., Korablev, O., Kojima, H., Lichtenegger, H., Livi, S., Matsuoka, A., Moissl, R., Moncuquet, M., Muinonen, K., Quèmerais, E., Saito, Y., Yagitani, S., Yoshikawa, I., and Wahlund, J. -E.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The ESA-JAXA BepiColombo mission will provide simultaneous measurements from two spacecraft, offering an unprecedented opportunity to investigate magnetospheric and exospheric dynamics at Mercury as well as their interactions with the solar wind, radiation, and interplanetary dust. Many scientific instruments onboard the two spacecraft will be completely, or partially devoted to study the near-space environment of Mercury as well as the complex processes that govern it. Many issues remain unsolved even after the MESSENGER mission that ended in 2015. The specific orbits of the two spacecraft, MPO and Mio, and the comprehensive scientific payload allow a wider range of scientific questions to be addressed than those that could be achieved by the individual instruments acting alone, or by previous missions. These joint observations are of key importance because many phenomena in Mercury's environment are highly temporally and spatially variable. Examples of possible coordinated observations are described in this article, analysing the required geometrical conditions, pointing, resolutions and operation timing of different BepiColombo instruments sensors., Comment: 78 pages, 14 figures, published

Published
2022
Full Text
View/download PDF

49. Magnetic Properties and Electronic Configurations of Mn Ions in the Diluted Magnetic Semiconductor Ba$_{1-x}$K$_{x}$(Zn$_{1-y}$Mn$_{y}$)$_{2}$As$_{2}$ Studied by X-ray Magnetic Circular Dichroism and Resonant Inelastic X-ray Scattering

Author

Suzuki, H., Zhao, G. Q., Okamoto, J., Sakamoto, S., Chen, Z. -Y., Nonaka, Y., Shibata, G., Zhao, K., Chen, B. J., Wu, W. -B., Chang, F. -H., Lin, H. -J., Chen, C. -T., Tanaka, A., Kobayashi, M., Gu, Bo, Maekawa, S., Uemura, Y. J., Jin, C. Q., Huang, D. J., and Fujimori, A.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

The magnetic properties and the electronic excitations of the new diluted magnetic semiconductor Ba$_{1-x}$K$_{x}$(Zn$_{1-y}$Mn$_{y}$)$_{2}$As$_{2}$ have been studied by x-ray magnetic circular dichroism (XMCD) and resonant inelastic x-ray scattering (RIXS) at the Mn $L_{2,3}$ edge. The sum rule analysis of the XMCD spectra yields the net spin moment of $0.45\mu_{\text{B}}$/Mn and the small orbital moment of $0.05\mu_{\text{B}}$/Mn. This indicates that the Mn atoms are in the high-spin configurations of $d^{5}$, whereas the presence of competing ferromagnetic and antiferromagnetic interactions between the Mn ions reduces the net spin moment. RIXS spectra show broad peaks from 1 to 6 eV energy loss, which originate from the $d$-$d$ crystal field excitations of the Mn ions. Based on a comparison of the RIXS line shapes with those of Ga$_{1-x}$Mn$_{x}$As, we conclude that the ground state of Mn in Ba$_{1-x}$K$_{x}$(Zn$_{1-y}$Mn$_{y}$)$_{2}$As$_{2}$ consists not only of the charge-transferred $3d^{5}\underline{L}$ electron configuration ($\underline{L}$: ligand hole) with weakly bound holes as in Ga$_{1-x}$Mn$_{x}$As, but also of the pure $3d^{5}$ configuration with free holes.

Published
2022
Full Text
View/download PDF

50. Application and modeling of an online distillation method to reduce krypton and argon in XENON1T

Author

Aprile, E., Abe, K., Agostini, F., Maouloud, S. Ahmed, Alfonsi, M., Althueser, L., Angelino, E., Angevaare, J. R., Antochi, V. C., Martin, D. Antón, Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Bernard, A., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Cimmino, B., Clark, M., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D'Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Di Giovanni, A., Di Stefano, R., Diglio, S., Elykov, A., Farrell, S., Ferella, A. D., Fischer, H., Form, S., Fulgione, W., Gaemers, P., Gaior, R., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Higuera, A., Hils, C., Hiraide, K., Hoetzsch, L., Howlett, J., Huhmann, C., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Kato, N., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Li, I., Liang, S., Lindemann, S., Lindner, M., Liu, K., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Manfredini, A., Marignetti, F., Undagoitia, T. Marrodán, Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Ni, K., Oberlack, U., Palacio, J., Peres, R., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., García, D. Ramírez, Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Santos, J. M. F. dos, Sartorelli, G., Schreiner, J., Schulte, D., Eißing, H. Schulze, Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P. -L., Terliuk, A., Therreau, C., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Wei, Y., Weinheimer, C., Weiss, M., Wenz, D., Westermann, J., Wittweg, C., Wolf, T., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zhang, Y., Zhong, M., Zhu, T., and Zopounidis, J. P.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

A novel online distillation technique was developed for the XENON1T dark matter experiment to reduce intrinsic background components more volatile than xenon, such as krypton or argon, while the detector was operating. The method is based on a continuous purification of the gaseous volume of the detector system using the XENON1T cryogenic distillation column. A krypton-in-xenon concentration of $(360 \pm 60)$ ppq was achieved. It is the lowest concentration measured in the fiducial volume of an operating dark matter detector to date. A model was developed and fit to the data to describe the krypton evolution in the liquid and gas volumes of the detector system for several operation modes over the time span of 550 days, including the commissioning and science runs of XENON1T. The online distillation was also successfully applied to remove Ar-37 after its injection for a low energy calibration in XENON1T. This makes the usage of Ar-37 as a regular calibration source possible in the future. The online distillation can be applied to next-generation experiments to remove krypton prior to, or during, any science run. The model developed here allows further optimization of the distillation strategy for future large scale detectors.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results