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1. Astrocytic stress response is induced by exposure to astrocyte-binding antibodies expressed by plasmablasts from pediatric patients with acute transverse myelitis

Author

Chad Smith, Kiel M. Telesford, Sara G. M. Piccirillo, Yamhilette Licon-Munoz, Wei Zhang, Key M. Tse, Jacqueline R. Rivas, Chaitanya Joshi, Dilan S. Shah, Angela X. Wu, Ritu Trivedi, Scott Christley, Yu Qian, Lindsay G. Cowell, Richard H. Scheuermann, Ann M. Stowe, Linda Nguyen, Benjamin M. Greenberg, and Nancy L. Monson

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Pediatric acute transverse myelitis (ATM) accounts for 20–30% of children presenting with a first acquired demyelinating syndrome (ADS) and may be the first clinical presentation of a relapsing ADS such as multiple sclerosis (MS). B cells have been strongly implicated in the pathogenesis of adult MS. However, little is known about B cells in pediatric MS, and even less so in pediatric ATM. Our lab previously showed that plasmablasts (PB), the earliest B cell subtype producing antibody, are expanded in adult ATM, and that these PBs produce self-reactive antibodies that target neurons. The goal of this study was to examine PB frequency and phenotype, immunoglobulin selection, and B cell receptor reactivity in pediatric patients presenting with ATM to gain insight to B cell involvement in disease. Methods We compared the PB frequency and phenotype of 5 pediatric ATM patients and 10 pediatric healthy controls (HC) and compared them to previously reported adult ATM patients using cytometric data. We purified bulk IgG from the plasma samples and cloned 20 recombinant human antibodies (rhAbs) from individual PBs isolated from the blood. Plasma-derived IgG and rhAb autoreactivity was measured by mean fluorescence intensity (MFI) in neurons and astrocytes of murine brain or spinal cord and primary human astrocytes. We determined the potential impact of these rhAbs on astrocyte health by measuring stress and apoptotic response. Results We found that pediatric ATM patients had a reduced frequency of peripheral blood PB. Serum IgG autoreactivity to neurons in EAE spinal cord was similar in the pediatric ATM patients and HC. However, serum IgG autoreactivity to astrocytes in EAE spinal cord was reduced in pediatric ATM patients compared to pediatric HC. Astrocyte-binding strength of rhAbs cloned from PBs was dependent on somatic hypermutation accumulation in the pediatric ATM cohort, but not HC. A similar observation in predilection for astrocyte binding over neuron binding of individual antibodies cloned from PBs was made in EAE brain tissue. Finally, exposure of human primary astrocytes to these astrocyte-binding antibodies increased astrocytic stress but did not lead to apoptosis. Conclusions Discordance in humoral immune responses to astrocytes may distinguish pediatric ATM from HC.

Published
2024
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2. Astrocytic stress response is induced by exposure to astrocyte-binding antibodies expressed by plasmablasts from pediatric patients with acute transverse myelitis

Author

Smith, Chad, Telesford, Kiel M., Piccirillo, Sara G. M., Licon-Munoz, Yamhilette, Zhang, Wei, Tse, Key M., Rivas, Jacqueline R., Joshi, Chaitanya, Shah, Dilan S., Wu, Angela X., Trivedi, Ritu, Christley, Scott, Qian, Yu, Cowell, Lindsay G., Scheuermann, Richard H., Stowe, Ann M., Nguyen, Linda, Greenberg, Benjamin M., and Monson, Nancy L.

Published
2024
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3. Cone-guided fast ignition with no imposed magnetic fields

Author

Strozzi D., Tabak M., Larson D., Marinak M., Key M., Divol L., Kemp A., Bellei C., and Shay H.

Subjects
Physics, QC1-999
Abstract

Simulations are presented of ignition-scale fast ignition targets with the integrated Zuma-Hydra PIC-hydrodynamic capability. We consider a spherical DT fuel assembly with a carbon cone, and an artificially-collimated fast electron source. We study the role of E and B fields and the fast electron energy spectrum. For mono-energetic 1.5 MeV fast electrons, without E and B fields, ignition can be achieved with fast electron energy Efig = 30kJ. This is 3.5× the minimal deposited ignition energy of 8.7 kJ for our fuel density of 450 g/cm3. Including E and B fields with the resistive Ohm's law E = ηJb gives Efig = 20kJ, while using the full Ohm's law gives Efig > 40 kJ. This is due to magnetic self-guiding in the former case, and ∇n ×∇T magnetic fields in the latter. Using a realistic, quasi two-temperature energy spectrum derived from PIC laser-plasma simulations increases Efig to (102, 81, 162) kJ for (no E/B, E = ηJb, full Ohm's law). Such electrons are too energetic to stop in the optimal hot spot depth.

Published
2013
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4. Implosion and heating experiments of fast ignition targets by Gekko-XII and LFEX lasers

Author

Shiraga H., Fujioka S., Nakai M., Watari T., Nakamura H., Arikawa Y., Hosoda H., Nagai T., Koga M., Kikuchi H., Ishii Y., Sogo T., Shigemori K., Nishimura H., Zhang Z., Tanabe M., Ohira S., Fujii Y., Namimoto T., Sakawa Y., Maegawa O., Ozaki T., Tanaka K.A., Habara H., Iwawaki T., Shimada K., Key M., Norreys P., Pasley J., Nagatomo H., Johzaki T., Sunahara A., Murakami M., Sakagami H., Taguchi T., Norimatsu T., Homma H., Fujimoto Y., Iwamoto A., Miyanaga N., Kawanaka J., Kanabe T., Jitsuno T., Nakata Y., Tsubakimoto K., Sueda K., Kodama R., Kondo K., Morio N., Matsuo S., Kawasaki T., Sawai K., Tsuji K., Murakami H., Sarukura N., Shimizu T., Mima K., and Azechi H.

Subjects
Physics, QC1-999
Abstract

The FIREX-1 project, the goal of which is to demonstrate fuel heating up to 5 keV by fast ignition scheme, has been carried out since 2003 including construction and tuning of LFEX laser and integrated experiments. Implosion and heating experiment of Fast Ignition targets have been performed since 2009 with Gekko-XII and LFEX lasers. A deuterated polystyrene shell target was imploded with the 0.53- μm Gekko-XII, and the 1.053- μm beam of the LFEX laser was injected through a gold cone attached to the shell to generate hot electrons to heat the imploded fuel plasma. Pulse contrast ratio of the LFEX beam was significantly improved. Also a variety of plasma diagnostic instruments were developed to be compatible with harsh environment of intense hard x-rays (γ rays) and electromagnetic pulses due to the intense LFEX beam on the target. Large background signals around the DD neutron signal in time-of-flight record of neutron detector were found to consist of neutrons via (γ,n) reactions and scattered gamma rays. Enhanced neutron yield was confirmed by carefully eliminating such backgrounds. Neutron enhancement up to 3.5 × 107 was observed. Heating efficiency was estimated to be 10–20% assuming a uniform temperature rise model.

Published
2013
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5. Progress and prospects for an IFE relevant FI point design

Author

Key M., Amendt P., Bellei C., Clark D., Cohen B., Divol L., Ho D., Kemp A., Larson D., Marinak M., Patel P., Shay H., Strozzi D., and Tabak M.

Subjects
Physics, QC1-999
Abstract

The physics issues involved in scaling from sub-ignition to high gain fast ignition are discussed. Successful point designs must collimate the electrons and minimise the standoff distance to avoid multi-megajoule ignition energies. Collimating B field configurations are identified and some initial designs are explored.

Published
2013
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6. Regulating sustainable development : an enabling model for consistent collaboration between planning and building control services in England

Author

Key, M. A.

Subjects
720
Abstract

Planning (often termed as development control) and building control have existed as public regulatory services on a national basis in England since the expansion of industrialisation in the 19th Century. Since then, the professions have collectively served the interests of local communities but have primarily worked in a mono-disciplinary context. This disciplinary isolation was compounded when the public building control system was opened up to competition from the private sector in the 1980s. Since the beginning of the 21st Century, building performance standards have become increasingly complex due to the introduction of sustainable development as a major policy objective. As a result, disciplinary boundaries have become blurred, with many stakeholders viewing regulation as a constraint to sustainable development. In light of the modern challenges of regulating the built environment, this thesis aims to develop a model with the capacity to enable consistent collaborative practice between planning and building control services in England. In doing so, it seeks to address problems associated with the disparate array of existing building performance standards, the resulting and widening regulatory skills gap and ultimately, the fragmented nature of the regulatory service delivery framework. In keeping with the problem solving ethos of the research, the design science research methodology was utilised, with research methods drawing upon a mixture of attributes common to consensus development and grounded theory research strategies. Building upon the author’s experiences as a building control manager, the adopted research approach resulted in iterative movements throughout the study between a broad base of existing knowledge and theory, and semi-structured interviews with experts in the field. The findings of the research indicate that the creation of domestic and commercial codes for sustainable development, interdisciplinary undergraduate educational initiatives and performance driven regulatory social enterprise offer the potential to address existing field based problems. In addition, evidence suggests that the model resulting from the study has the capability to move the often conflicting processes of design and regulation towards being conjoined as part of a dynamic unfolding process with sustainable outcomes.

Published
2016

7. Fast-ignition design transport studies: realistic electron source, integrated PIC-hydrodynamics, imposed magnetic fields

Author

Strozzi, D. J., Tabak, M., Larson, D. J., Divol, L., Kemp, A. J., Bellei, C., Marinak, M. M., and Key, M. H.

Subjects
Physics - Plasma Physics
Abstract

Transport modeling of idealized, cone-guided fast ignition targets indicates the severe challenge posed by fast-electron source divergence. The hybrid particle-in-cell [PIC] code Zuma is run in tandem with the radiation-hydrodynamics code Hydra to model fast-electron propagation, fuel heating, and thermonuclear burn. The fast electron source is based on a 3D explicit-PIC laser-plasma simulation with the PSC code. This shows a quasi two-temperature energy spectrum, and a divergent angle spectrum (average velocity-space polar angle of 52 degrees). Transport simulations with the PIC-based divergence do not ignite for > 1 MJ of fast-electron energy, for a modest 70 micron standoff distance from fast-electron injection to the dense fuel. However, artificially collimating the source gives an ignition energy of 132 kJ. To mitigate the divergence, we consider imposed axial magnetic fields. Uniform fields ~50 MG are sufficient to recover the artificially collimated ignition energy. Experiments at the Omega laser facility have generated fields of this magnitude by imploding a capsule in seed fields of 50-100 kG. Such imploded fields are however more compressed in the transport region than in the laser absorption region. When fast electrons encounter increasing field strength, magnetic mirroring can reflect a substantial fraction of them and reduce coupling to the fuel. A hollow magnetic pipe, which peaks at a finite radius, is presented as one field configuration which circumvents mirroring., Comment: 16 pages, 17 figures, submitted to Phys. Plasmas

Published
2012
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8. Cone-Guided Fast Ignition with no Imposed Magnetic Fields

Author

Strozzi, D. J., Tabak, M., Larson, D. J., Marinak, M. M., Key, M. H., Divol, L., Kemp, A. J., Bellei, C., and Shay, H. D.

Subjects
Physics - Plasma Physics
Abstract

Simulations of ignition-scale fast ignition targets have been performed with the new integrated Zuma-Hydra PIC-hydrodynamic capability. We consider an idealized spherical DT fuel assembly with a carbon cone, and an artificially-collimated fast electron source. We study the role of E and B fields and the fast electron energy spectrum. For mono-energetic 1.5 MeV fast electrons, without E and B fields, the energy needed for ignition is E_f^{ig} = 30 kJ. This is about 3.5x the minimal deposited ignition energy of 8.7 kJ for our fuel density of 450 g/cm^3. Including E and B fields with the resistive Ohm's law E = \eta J_b gives E_f^{ig} = 20 kJ, while using the full Ohm's law gives E_f^{ig} > 40 kJ. This is due to magnetic self-guiding in the former case, and \nabla n \times \nabla T magnetic fields in the latter. Using a realistic, quasi two-temperature energy spectrum derived from PIC laser-plasma simulations increases E_f^{ig} to (102, 81, 162) kJ for (no E/B, E = \eta J_b, full Ohm's law). This stems from the electrons being too energetic to fully stop in the optimal hot spot depth., Comment: Minor revisions in response to referee comments

Published
2011

9. Acidosis, a fundamental regulator of bone cell function

Author

Key, M. L.

Subjects
616.3
Abstract

Previous work has demonstrated that bone cells are highly sensitive to extracellular acidification. Low pH is a key osteoclast activation factor, and reduces bone formation by inhibiting mineralisation of the matrix. The aim of this thesis was to investigate further the roles played by pH in modulating bone cell function. Transient receptor potential (TRP) channels detect protons within the pathophysiological range, so are potential candidates for mediating the observed effects of acid on bone cells. I found that TRPV1 agonists/antagonists had no effect on osteoclast formation and activation or bone mineralisation by osteoblasts. Additionally, TRPV1-/- osteoclasts demonstrated no functional differences from wildtypes. Furthermore, agonists/antagonists for TRPM8, TRPV4 and TRPV3 were without effect. Pyrophosphate (PPi) a fundamental inhibitor of mineralisation in the bone microenvironment is generated from extracellular nucleotides by ecto-nucleotidases such as E-NPP1. I showed that E-NPP1 mRNA and protein were up-regulated in osteoblasts cultured at pH 6.9; total E-NPP activity was also increased. To determine the role of acidification in tumour-induced osteolysis, I devised an in vitro model to investigate interactions of osteoclasts with breast cancer cells, which metastasise to bone, sometimes causing osteolytic disease. Surprisingly, the overall effect of breast cancer cells on osteoclasts was inhibitory; however, resorption was significantly stimulated relative to buffered controls when breast cancer cells were allowed to acidify the culture medium. These results suggest that local acidification in tumour settings in vivo could be an important factor in determining the degree of osteolysis that occurs. Finally, I investigated whether two key cytokines implicated in the vicious cycle model of tumour-mediated osteolysis, B-cell activating factor (BAFF) and activin A influence osteoclast function. In all experiments only acidosis stimulated osteoclast resorption. These results provide further evidence for the fundamental role of acid as a regulator of bone cell function.

Published
2012

11. A Saturated X-ray Laser Beam at 7 Nanometers

Author

Zhang, J., MacPhee, A. G., Lin, J., Wolfrum, E., Smith, R., Danson, C., Key, M. H., Lewis, C. L. S., Neely, D., Nilsen, J., Pert, G. J., Tallents, G. J., and Wark, J. S.

Published
1997

16. Present states and future prospect of fast ignition realization experiment (FIREX) with Gekko and LFEX Lasers at ILE

Author

Koga, Mayuko, Arikawa, Y., Azechi, H., Fujimoto, Y., Fujioka, S., Habara, H., Hironaka, Y., Homma, H., Hosoda, H., Jitsuno, T., Johzaki, T., Kawanaka, J., Kodama, R., Mima, K., Miyanaga, N., Murakami, M., Nagatomo, H., Nakai, M., Nakata, Y., Nakamura, H., Nishimura, H., Norimatsu, T., Sakawa, Y., Sarukura, N., Shigemori, K., Shiraga, H., Shimizu, T., Takabe, H., Tanabe, M., Tanaka, K.A., Tanimoto, T., Tsubakimoto, T., Watari, T., Sunahara, A., Isobe, M., Iwamoto, A., Mito, T., Motojima, O., Ozaki, T., Sakagami, H., Taguchi, T., Nakao, Y., Cai, H., Key, M., Norreys, P., and Pasley, J.

Published
2011
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24. Comparison of radiation hardness of P-in-N, N-in-N, and N-in-P silicon pad detectors

Author

Lozano, M., Pellegrini, G., Fleta, C., Loderer, C., Rafi, J.M., Ullan, M., Campabadal, F., Martinez, C., Key, M., Casse, G., and Allport, P.

Subjects
Detectors -- Mechanical properties, Detectors -- Comparative analysis, Business, Electronics, Electronics and electrical industries
Abstract

The very high radiation fluence expected at LHC (Large Hadron Collider) at CERN will induce serious changes in the electrical properties of the silicon detectors that will be used in the internal layers of the experiments (ATLAS, CMS, LHCb). To understand the influence of the fabrication technology in the radiation-induced degradation, silicon detectors were fabricated simultaneously with the three different possible technologies, P-in-N, N-in-N, and N-in-P, on standard and oxygenated float-zone silicon wafers. The diodes were irradiated with protons to fluences up to [10.sup.15] [cm.sup.-2]. The measurements of the electrical characteristics, current-voltage and capacitance-voltage, are presented for the detectors manufactured with the three technologies. In terms of alpha factor (leakage current) the three technologies behave similarly. In terms of beta factor (effective doping concentration) N-in-P devices show the best performances. Index Terms--Detector technology, N-in-N, N-in-P, P-in-N, radiation hardness, silicon radiation detectors.

Published
2005

26. Plasma devices to guide and collimate a high density of MeV electrons

Author

Kodama, R., Sentoku, Y., Chen, Z. L., Kumar, G. R., Hatchett, S. P., Toyama, Y., Cowan, T. E., Freeman, R. R., Fuchs, J., Izawa, Y., Key, M. H., Kitagawa, Y., Kondo, K., Matsuoka, T., Nakamura, H., Nakatsutsumi, M., Norreys, P. A., Norimatsu, T., Snavely, R. A., Stephens, R. B., Tampo, M., Tanaka, K. A., and Yabuuchi, T.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): R. Kodama (corresponding author) [1]; Y. Sentoku [2]; Z. L. Chen [1]; G. R. Kumar [1, 8]; S. P. Hatchett [3]; Y. Toyama [1]; T. E. Cowan [2]; R. [...]

Published
2004
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27. Trimethylantimony Dihalides

Author

Doak, G. O., primary, Long, G. G., additional, Key, M. E., additional, Bush, Lee W., additional, Thompson, David W., additional, and Allred, A. L., additional

Published
2007
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30. Design and performance of the ABCD3TA ASIC for readout of silicon strip detectors in the ATLAS semiconductor tracker

Author

Campabadal, F., Fleta, C., Key, M., Lozano, M., Martinez, C., Pellegrini, G., Rafi, J.M., Ullan, M., Johansen, L.G., Mohn, B., Oye, O., Solberg, A.O., Stugu, B., Ciocio, A., Ely, R., Fadeyev, V., Gilchriese, M., Haber, C., Siegrist, J., Spieler, H., Vu, C., Bell, P.J., Charlton, D.G., Dowell, J.D., Gallop, B.J., Homer, R.J., Jovanovic, P., Mahout, G., McMahon, T.J., Wilson, J.A., Barr, A.J., Carter, J.R., Goodrick, M.J., Hill, J.C., Lester, C.G., Parker, M.A., Robinson, D., Anghinolfi, F., Chesi, E., Jarron, P., Kaplon, J., Macpherson, A., Pernegger, H., Pritchard, T., Roe, S., Rudge, A., Weilhammer, P., Bialas, W., Dabrowski, W., Dwuznik, M., Toczek, B., Koperny, S., Bruckman, P., Gadomski, S., Gornicki, E., Malecki, P., Moszczynski, A., Stanecka, E., Szczygiel, R., Turala, M., Wolter, M., Feld, L., Ketterer, C., Ludwig, J., Meinhardt, J., Runge, K., Clark, A.G., Donega, M., D’Onofrio, M., Ferrere, D., La Marra, D., Macina, D., Mangin-Brinet, M., Mikulec, B., Zsenei, A., Bates, R.L., Cheplakov, A., Iwata, Y., Ohsugi, T., Ikegami, Y., Kohriki, T., Kondo, T., Terada, S., Ujiie, N., Unno, Y., Takashima, R., Allport, P.P., Greenall, A., Jackson, J.N., Jones, T.J., Smith, N.A., Beck, G.A., Carter, A.A., Morris, J., Morin, J., Cindro, V., Kramberger, G., Mandić, I., Mikuž, M., Duerdoth, I.P., Foster, J.M., Pater, J., Snow, S.W., Thompson, R.J., Atkinson, T.M., Dick, B., Fares, F., Moorhead, G.F., Taylor, G.N., Andricek, L., Bethke, S., Hauff, D., Kudlaty, J., Lutz, G., Moser, H.-G., Nisius, R., Richter, R., Schieck, J., Colijn, A-P., Cornelissen, T., Gorfine, G.W., Hartjes, F.G., Hessey, N.P., de Jong, P., Kluit, R., Koffeman, E., Muijs, A.J.M., Peeters, S.J.M., van Eijk, B., Nakano, I., Tanaka, R., Dorholt, O., Danielsen, K.M., Huse, T., Sandaker, H., Stapnes, S., Kundu, N., Nickerson, R.B., Weidberg, A., Bohm, J., Mikestikova, M., Stastny, J., Broklova, Z., Broz, J., Dolezal, Z., Kodys, P., Kubik, P., Reznicek, P., Vorobel, V., Wilhelm, I., Cermák, P., Chren, D., Horazdovský, T., Linhart, V., Pospísil, S., Sinor, M., Solar, M., Sopko, B., Stekl, I., Apsimon, R.J., Batchelor, L.E., Bizzell, J.P., Falconer, N.G., French, M.J., Gibson, M.D., Haywood, S.J., Matson, R.M., McMahon, S.J., Morrissey, M., Murray, W.J., Phillips, P.W., Tyndel, M., Villani, E.G., Cosgrove, D.P., Dorfan, D.E., Grillo, A.A., Kachiguine, S., Rosenbaum, F., Sadrozinski, H.F.-W., Seiden, A., Spencer, E., Wilder, M., Akimoto, T., Hara, K., Tanizaki, K., Bingefors, N., Brenner, R., Ekelof, T., Eklund, L., Bernabeu, J., Civera, J.V., Costa, M.J., Fuster, J., Garcia, C., Garcia-Navarro, J.E., Gonzalez-Sevilla, S., Lacasta, C., Llosa, G., Marti-Garcia, S., Modesto, P., Sanchez, F.J., Sospedra, L., and Vos, M.

Published
2005
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31. Beam tests of ATLAS SCT silicon strip detector modules

Author

Campabadal, F., Fleta, C., Key, M., Lozano, M., Martinez, C., Pellegrini, G., Rafi, J.M., Ullan, M., Johansen, L., Pommeresche, B., Stugu, B., Ciocio, A., Fadeyev, V., Gilchriese, M., Haber, C., Siegrist, J., Spieler, H., Vu, C., Bell, P.J., Charlton, D.G., Dowell, J.D., Gallop, B.J., Homer, R.J., Jovanovic, P., Mahout, G., McMahon, T.J., Wilson, J.A., Barr, A.J., Carter, J.R., Fromant, B.P., Goodrick, M.J., Hill, J.C., Lester, C.G., Palmer, M.J., Parker, M.A., Robinson, D., Sabetfakhri, A., Shaw, R.J., Anghinolfi, F., Chesi, E., Chouridou, S., Fortin, R., Grosse-Knetter, J., Gruwe, M., Ferrari, P., Jarron, P., Kaplon, J., Macpherson, A., Niinikoski, T., Pernegger, H., Roe, S., Rudge, A., Ruggiero, G., Wallny, R., Weilhammer, P., Bialas, W., Dabrowski, W., Grybos, P., Koperny, S., Blocki, J., Bruckman, P., Gadomski, S., Godlewski, J., Gornicki, E., Malecki, P., Moszczynski, A., Stanecka, E., Stodulski, M., Szczygiel, R., Turala, M., Wolter, M., Ahmad, A., Benes, J., Carpentieri, C., Feld, L., Ketterer, C., Ludwig, J., Meinhardt, J., Runge, K., Mikulec, B., Mangin-Brinet, M., D’Onofrio, M., Donega, M., Moêd, S., Sfyrla, A., Ferrere, D., Clark, A.G., Perrin, E., Weber, M., Bates, R.L., Cheplakov, A., Saxon, D.H., O’Shea, V., Smith, K.M., Iwata, Y., Ohsugi, T., Kohriki, T., Kondo, T., Terada, S., Ujiie, N., Ikegami, Y., Unno, Y., Takashima, R., Brodbeck, T., Chilingarov, A., Hughes, G., Ratoff, P., Sloan, T., Allport, P.P., Casse, G.-L., Greenall, A., Jackson, J.N., Jones, T.J., King, B.T., Maxfield, S.J., Smith, N.A., Sutcliffe, P., Vossebeld, J., Beck, G.A., Carter, A.A., Lloyd, S.L., Martin, A.J., Morris, J., Morin, J., Nagai, K., Pritchard, T.W., Anderson, B.E., Butterworth, J.M., Fraser, T.J., Jones, T.W., Lane, J.B., Postranecky, M., Warren, M.R.M., Cindro, V., Kramberger, G., Mandić, I., Mikuž, M., Duerdoth, I.P., Freestone, J., Foster, J.M., Ibbotson, M., Loebinger, F.K., Pater, J., Snow, S.W., Thompson, R.J., Atkinson, T.M., Bright, G., Kazi, S., Lindsay, S., Moorhead, G.F., Taylor, G.N., Bachindgagyan, G., Baranova, N., Karmanov, D., Merkine, M., Andricek, L., Bethke, S., Kudlaty, J., Lutz, G., Moser, H.-G., Nisius, R., Richter, R., Schieck, J., Cornelissen, T., Gorfine, G.W., Hartjes, F.G., Hessey, N.P., de Jong, P., Muijs, A.J.M., Peeters, S.J.M., Tomeda, Y., Tanaka, R., Nakano, I., Dorholt, O., Danielsen, K.M., Huse, T., Sandaker, H., Stapnes, S., Bargassaa, P., Reichold, A., Huffman, T., Nickerson, R., Weidberg, A., Doucas, G., Hawes, B., Lau, W., Howell, D., Kundu, N., Wastie, R., Bohm, J., Mikestikova, M., Stastny, J., Broklová, Z., Brož, J., Doležal, Z., Kodyš, P., Kubík, P., Řezníček, P., Vorobel, V., Wilhelm, I., Chren, D., Horazdovsky, T., Linhart, V., Pospisil, S., Sinor, M., Solar, M., Sopko, B., Stekl, I., Ardashev, E.N., Golovnya, S.N., Gorokhov, S.A., Kholodenko, A.G., Rudenko, R.E., Ryadovikov, V.N., Vorobiev, A.P., Adkin, P.J., Apsimon, R.J., Batchelor, L.E., Bizzell, J.P., Booker, P., Davis, V.R., Easton, J.M., Fowler, C., Gibson, M.D., Haywood, S.J., MacWaters, C., Matheson, J.P., Matson, R.M., McMahon, S.J., Morris, F.S., Morrissey, M., Murray, W.J., Phillips, P.W., Tyndel, M., Villani, E.G., Dorfan, D.E., Grillo, A.A., Rosenbaum, F., Sadrozinski, H.F.-W., Seiden, A., Spencer, E., Wilder, M., Booth, P., Buttar, C.M., Dawson, I., Dervan, P., Grigson, C., Harper, R., Moraes, A., Peak, L.S., Varvell, K.E., Chu, Ming-Lee, Hou, Li-Shing, Lee, Shih-Chang, Teng, Ping-Kun, Wan, Changchun, Hara, K., Kato, Y., Kuwano, T., Minagawa, M., Sengoku, H., Bingefors, N., Brenner, R., Ekelöf, T., Eklund, L., Bernabeu, J., Civera, J.V., Costa, M.J., Fuster, J., Garcia, C., Garcia, J.E., Gonzalez-Sevilla, S., Lacasta, C., Llosa, G., Marti-Garcia, S., Modesto, P., Sanchez, J., Sospedra, L., Vos, M., Fasching, D., Gonzalez, S., Jared, R.C., and Charles, E.

Published
2005
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32. Development of XUV lasers at the RAL Central Laser Facility

Author

Key, M. H., Blyth, W. J., Dangor, A. E., Dhez, P., Djoui, A., Dwivedi, L., Holden, M., Holden, P. B., Jaegle, P., Lewis, C. L. S., McPhee, A. G., Modena, A., Nakai, M., Neely, D., Norreys, P. A., Offenberger, A. A., Pert, G. J., Ploues, J. A., Preston, S. G., Ramsden, S. A., Rose, S. J., Russ, B., Smith, C. G., Sureau, A., Tallents, G. J., Walsh, F., Wark, J. S., You, Y. L., and Zhang, J.

Published
1996
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34. Theodore Roosevelt, the rough riders and the alteration of myth

Author

Key, M. Dvaid

Subjects
Popular culture -- Analysis, Regional focus/area studies
Abstract

Theodore Roosevelt's book, 'Winning the West' relates the story of a local militia called 'Over-the-Mountain Boys' who won battles on foot. After a decade of its writing, Roosevelt led to battle a same type of group, which was grown to be called 'Rough Riders.' This incident is a perfect example of how an event of history becomes a part of a myth that is open to alteration with the moving time. However, only the details are changed but the outline remains intact.

Published
1998

41. General Discussion

Author

Lackner, K., Sheffield, J., Key, M., Hawryluk, R. J., Robinson, D. C., Aymar, R., Kelly, A., and Bruhns, H.

Published
1999

44. Downwash for joined-wing airframe with control surface deflections

Author

Burkhalter, John E., Spring, Donald J., and Key, M. Kent

Subjects
Airplanes -- Wings, Airframes -- Analysis, Aerospace and defense industries, Business, Science and technology
Abstract

The downwash effects for a joined-wing aircraft are investigated using experimental and theoretical approaches. The investigation was designed to include basic downwash equations used in the prediction of the downwash effects from the forward wing as well as the upwash effects from the rear wing. The basic equations are modified and presented with the experimental data for comparison.

Published
1992

47. LONGITUDINAL ANALYSES OF DIAGNOSTIC-RELAPSE BIOPSIES OF DIFFUSE LARGE B CELL LYMPHOMA SUGGEST THAT RELAPSE IS MEDIATED BY DISTINCT MECHANISMS IN ABC AND GCB LYMPHOMA

Author

Korfi, K., primary, Araf, S., additional, Bewicke-Copley, F., additional, Kumar, E., additional, Cummin, T., additional, Ashton-Key, M., additional, Barrans, S., additional, Van Hoppe, S., additional, Burton, C., additional, Elshiekh, M., additional, Rule, S., additional, Crosbie, N., additional, Clear, A., additional, Calaminici, M., additional, Menon, G., additional, Sha, C., additional, Bentley, M., additional, Nagano, A., additional, Davies, A., additional, Painter, D., additional, Smith, A., additional, Okosun, J., additional, Gribben, J., additional, Naresh, K.N., additional, Westhead, D., additional, Wang, J., additional, Johnson, P., additional, and Fitzgibbon, J., additional

Published
2019
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