1. The incidence of bleomycin induced lung toxicity is increased in Hodgkin lymphoma patients over 45 years exposed to granulocyte-colony stimulating growth factor.
- Author
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Andersen, Maja D., Kamper, Peter, d'Amore, Alexander, Clausen, Michael, Bentzen, Hans, and d'Amore, Francesco
- Subjects
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GRANULOCYTE-colony stimulating factor , *HODGKIN'S disease , *PULMONARY fibrosis , *BLEOMYCIN , *PROGRESSION-free survival , *AGE groups - Abstract
In Hodgkin lymphoma (HL) bleomycin can induce pulmonary toxicity (BPT). BPT consists of respiratory tract symptoms during bleomycin-exposure and radiologic pulmonary lesions without concomitant infection. Older age, bleomycin dose, smoking history and the use of granulocyte-colony stimulating factor (G-CSF) have been suggested as possible risk factors for BPT. It is still debated whether BPT affects overall (OS) and progression-free survival (PFS). We investigated the incidence of BPT along with possible risk factors in 412 HL patients treated in 1990-2014. BPT occurred in 34 patients (8%) and was significantly associated with disseminated disease and B-symptoms. It was more frequent in elderly patients (p =.05) but not significantly correlated with a history of smoking. BPT occurred more often in patients receiving G-CSF (p =.03), particularly the poly-ethylenglycol-bound molecule. All significant risk correlations were limited to the age group >45 years. In the present cohort, BPT did not influence OS or PFS regardless of age. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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