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Factors associated with risk and prognosis of intensive care unit admission in patients with acute leukemia: a Danish nationwide cohort study.
- Source :
-
Leukemia & Lymphoma . Oct2022, Vol. 63 Issue 10, p2290-2300. 11p. - Publication Year :
- 2022
-
Abstract
- Identifying risk factors for intensive care unit (ICU) admission in acute leukemia (AL) patients may guide decision-making and improve prognosis. We included all adult AL patients receiving high-intensive chemotherapy in Denmark from 2005 to 2016. We examined risk factors [crude and adjusted (a) relative risks (RRs) with 95% confidence intervals (CI)] and calculated RRs of death after 1-, 3-, and 5-years in ICU-admitted patients compared with matched cohorts. In 1417 AML and 306 ALL patients, the 1-year risk of ICU admission was 28.1% for AML and 26.4% for ALL patients, with the majority related to the first course of chemotherapy. Performance status >1 was associated with increased risk. The 1-year mortality was higher in ICU-admitted patients (AML: 69.7 vs. 35.0% [aRR 2.74;CI = 2.17–3.47]; ALL 65.0 vs. 20.0% [aRR 3.04;CI = 1.54–6.02]). The excess mortality decreased with time. In this study, performance status was associated with increased risk of ICU admission and identifies high-risk patients. ICU admission was associated with high mortality, especially within the first year. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTENSIVE care patients
*ACUTE leukemia
*COHORT analysis
*INTENSIVE care units
Subjects
Details
- Language :
- English
- ISSN :
- 10428194
- Volume :
- 63
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Leukemia & Lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 159584044
- Full Text :
- https://doi.org/10.1080/10428194.2022.2074984