24 results on '"J. Sehonou"'
Search Results
2. Sociodemographic characteristics and identified needs among patients followed in palliative care units in the Republic of Benin
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Hounsa A, Zannou Dm, Ayosso M, Ezin-Houngbe J, Sowanou Akv, Houngbe F, Prudencio Rdtk, Djossou G, Gnangnon F, J. Sehonou, Aguegue A, Kouassi Zannou L, Gnintoungbe S, Watchinou Fv, and Agbod
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Clinical trial ,medicine.medical_specialty ,Palliative care ,business.industry ,Family medicine ,Epidemiology ,medicine ,business - Published
- 2019
3. Acute mesenteric ischemia revealing cirrhosis: about a clinical case
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Kpossou, Aboudou Raïmi, primary, CNM, Sokpon, additional, MM, Doukpo, additional, EW, Gandji, additional, K, Diallo, additional, C, Laleye, additional, RK, ignon, additional, YOT, Eyisse-Kpossou, additional, and J, Sehonou, additional
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- 2020
- Full Text
- View/download PDF
4. La dilatation pneumatique de l’achalasie au stade de méga-œsophage à cotonou
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J. Sehonou, R. K. Vignon, J. L. Olory-Togbe, N. Kodjoh, L. Fanou, and A. Gnangnon
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Gynecology ,medicine.medical_specialty ,Infectious Diseases ,Hepatology ,business.industry ,Tropical medicine ,Gastroenterology ,Medicine ,business - Abstract
L’achalasie diagnostiquee au stade de megaoesophage dans notre population, est consideree comme un trouble moteur oesophagien primitif apres elimination de toute lesion organique. Auparavant, le traitement etait uniquement chirurgical. Nous rapportons notre experience en matiere de la dilatation pneumatique de l’achalasie chez trois patients sur cinq admis consecutivement pour une dysphagie chronique sur mega-oesophage. La dilatation au ballon a ete realisee sans la moindre complication sous sedation au propofol. L’evolution a ete marquee par une amelioration clinique satisfaisante depuis 12 mois de suivi.
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- 2014
5. Évolution du risque cardiovasculaire des patients traités pour HTA à l’hôpital d’instruction des armées de Cotonou
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Hippolyte Agboton, B. Awanou, F. Hounto, J. Sehonou, R. Lawani, M. d’Almeida-Massougbodji, Dèdonougbo Martin Houénassi, R. Akindès-Dossou Yovo, Jeanne Vehounkpe-Sacca, F. Atadokpede, Y. Tchabi, and A. Gnangnon
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Gynecology ,medicine.medical_specialty ,Black african ,business.industry ,Medicine ,Cardiology and Cardiovascular Medicine ,business - Abstract
Resume Cette etude a ete initiee pour determiner l’evolution a cinq ans du risque cardiovasculaire chez les hypertendus traites. Il s’agit d’une etude retrospective descriptive sur une periode de neuf ans. Ont ete inclus les patients de race noire pris en charge pour HTA dans la periode de l’etude et qui ont un suivi d’au moins cinq ans. Le risque cardiovasculaire global (RCVA) a ete calcule a posteriori, pour les besoins de l’etude, a l’aide des tables de Framingham. Toutes les donnees ont ete recueillies apres la premiere evaluation puis actualisees aux echeances d’un, trois, cinq ans et a la derniere consultation pour les patients dont le suivi a excede cinq ans. Pour les 103 patients qui avaient des donnees completes l’âge moyen etait de 49,11 ± 8 ans et la sex-ratio de 2. Parmi eux 14 (13,6 %) sont decedes de complications cardiovasculaires. Parmi les 89 survivants le risque cardiovasculaire au debut etait tres eleve dans 10,1 %, eleve dans 49,4 %, modere dans 22,5 % et faible dans 18 %. L’evolution generale est caracterisee par une stabilite de la proportion du RCVA modere (20–23 %) et du RCVA eleve (43–50 %) mais une tres importante augmentation de la proportion du RCVA tres eleve (10 a 21 %) au detriment du RCVA faible (18 a 10 %). L’analyse de l’evolution individuelle revele une amelioration du RCVA chez 19 patients (21,3 %), une stabilite du RCVA chez 39 patients (43,8 %) et une aggravation chez 31 patients (34,8 %). Ces donnees se confirment dans une population elargie de 320 patients dont les donnees moins completes permettent une estimation du RCVA. Conclusion Le risque cardiovasculaire est difficile a evaluer. Il est mal controle a long terme.
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- 2013
6. Manifestations digestives au cours du diabète à Cotonou (République du Bénin)
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F. Djrolo, D. K. Amoussou-Guenou, J. Sehonou, and S. E. Glitho
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Gynecology ,medicine.medical_specialty ,Infectious Diseases ,Hepatology ,business.industry ,education ,Tropical medicine ,Gastroenterology ,medicine ,business - Abstract
But Rapporter la nature, la frequence et les facteurs associes a la survenue de symptomes digestifs, au sein d’une population suivie pour diabete.
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- 2011
7. Tolérance hépatique de l’association Artéméther-Luméfantrine dans le traitement de l’accès palustre simple chez des enfants au Bénin
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A. Dade, A. Ogouyemi-Hounto, A. Massougbodji, N. Kodjoh, D. Kinde-Gazard, J. Sehonou, and B. Mazu
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Gynecology ,medicine.medical_specialty ,Hepatology ,business.industry ,Gastroenterology ,Lumefantrine ,medicine.disease ,chemistry.chemical_compound ,Infectious Diseases ,chemistry ,Tropical medicine ,medicine ,Artemether ,Protozoal disease ,business ,Malaria ,medicine.drug - Abstract
Resume Le but de la presente etude est d’evaluer la tolerance hepatique de la combinaison artemether-lumefantrine (AL) utilisee dans le traitement du paludisme simple au Benin.
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- 2009
8. Étude descriptive de 2 722 œsogastro duodénopathies à l’hôpital militaire de Cotonou: inflammations chez les femmes, ulcères chez les hommes
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J. Sehonou, N. Kodjoh, and B. Addra
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Gynecology ,medicine.medical_specialty ,medicine.diagnostic_test ,Esophagogastroduodenoscopy ,business.industry ,medicine ,Radiology, Nuclear Medicine and imaging ,Interventional radiology ,business ,Abdominal surgery ,Gastrointestinal endoscopy - Abstract
Le but de cette etude est d’etablir chez des patients admis pour une œso-gastro-duodenoscopie diagnostique, la nature, l’importance, et les raisons des differences observees entre hommes et femmes.
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- 2006
9. Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries
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I. Izabelle, F. Ello, H. Ssemuwemba, S. Phiri, J. Olasode, Marie-Sylvie N’Gbeche, S. Kouadio, Jesper Eugen-Olsen, M. Mpoudi-Etame, Cristin Q. Fritz, S. Dapiap, J. Zoungrana, Antoine Jaquet, Aristophane Tanon, Rasmata Ouédraogo, N. T. Loan, E. J. Carter, Obaseki, F. F. Diakité, H. X. Zhao, Kulkanya Chokephaibulkit, Z. J. da Silva, Peter Aaby, Dewi Kumara Wati, David da Silva, L. Ayangma, K. Jjingo, P. Kim, Romanee Chaiwarith, James Ndirangu, Valériane Leroy, L. P. P. Atmikasari, N. Zobo, H. Chenal, Rita Lyamuya, Catherine C. McGowan, Keswadee Lapphra, Wanatpreeya Phongsamart, B. B. Mwebesa, Théodore Niyongabo, D. Katile, B. Ba, Matthias Egger, L. Mofenson, A. Mounkaila-Harouna, Boris Tchounga, M. Moh, Elom Takassi, Haby Signaté Sy, G. Sagbo, F. Kaeser, Eduardo Gotuzzo, Guillaume Bado, C. C. McGowan, S. Karcher, Constantin T. Yiannoutsos, V. H. Bui, Christopher J. Hoffmann, Didier K. Ekouevi, J. Akakpo, I. Azinyue, S. Kiertiburanakul, S. O. Koule, W. Bishai, Mariam Guindo Traoré, C. Williams, Elise Arrivé, A. Tapsoba, S. Bessekon, Patrick A. Coffie, F. Yuliana, A. Gougounon-Houéto, Somnuek Sungkanuparph, Y. Abo, Q. Vo, Praphan Phanuphak, M. B. Kokora, Kouadio Kouakou, Fla Kouéta, M. E. Dainguy, O. Benson, I. Soré, W. Prasitsuebsai, Harry Moultrie, C. Guehi, Beatriz Grinsztejn, T. Q. Du, L. Diecket Ahoussou, Z. Diallo, N. Traoré, Firas Wehbe, C. V. Do, J. Tatwangire, A. Kotosso, F. Soppi, Amabelia Rodrigues, Juan Sierra Madero, P. S. Sow, Rodolphe Thiébaut, I. Y. Malino, Moussa Seydi, Helena Rabie, A. Dienderé, Geoffrey Somi, Emmanuel Bissagnene, Elizabeth A. Bukusi, H. C. Traoré, David A. Cooper, N. M. Manga, P. Osakede, S. Ajayi, J. Paulo, Marguerite Timite-Konan, Andrew Edmonds, B. Diop, A. M. Traoré, W. Hiembo, A. Koïta, M. Faye, A. Azon-Kouanou, Christian Wejse, Claudia P. Cortes, T. Pety, N. Durier, Thira Sirisanthana, Camille Ndondoki, Karl-Günter Technau, J. S. Elvis Diby, G. Alim, M. D'Almeida, A. Komi, J. Bashi, J. M. Tine, D. Hawerlander, R. Ditangco, Akouda Patassi, A. Kalle, F. J. Zhang, Lorna Renner, N. H. Chau, Janet Giddy, G. Clouet, Samwel O. Ayaya, A. Sohn, Lars Østergaard, Sylvie Ouédraogo, Clement Adebamowo, Azar Kariminia, John Ssali, Joseph Drabo, M. Dembelé, Nicola Maxwell, Albert Minga, M. D.N. Amego, Wilai Kotarathititum, Christian Erikstrup, H. A. Traore, Kapella Zacharia Ngonyani, E. Geng, Lukas Fenner, A. Diagne, Marcelo Wolff, A. I. Assi, A. Sackey, A. R. Yao, M. F. Sami, Edmond Addi Aka, H. Adjide, Pagakrong Lumbiganon, Karen Malateste, L. Diero, M. Gansonré, P. N. An, A. H. Sohn, D. Meless, D. Avit-Edi, D. Walker, L. Hardwicke, A. S. Kaya, Véronique Mea-Assande, G. S. Gottlieb, Denis Padgett, Eric Balestre, Candida Medina, D. Amani, C. Kouakou, C. Shiboski, E Messou, B. G. Kariyare, M. Ballif, W. Wester, J. M. Gonsan, G. Gbadamassi, A. Ba, M. Fomba, Denis Malvy, R. Bantique, S. N. Owiafe, Andrew Kambugu, Festus Igbinoba, M. Y. Maiga, C. Ahomadegbé, A. Berthé, R. D. Gueye, C. C. Bassabi, Djimon Marcel Zannou, Olivia Keiser, Kara Wools-Kaloustian, K. E. Mensah-Zukong, A. Doring, C. Chimbetete, J. Rivenc, V. Andavi, F. Alihonou, S. Datté, S. Pestilli, T. Mengthaisong, Kathryn Anastos, A. D. Mbaye, D. Lameck, Claire Graber, J. Lewis-Kulzer, G. Reubenson, B. Siloué, Marcel Yotebieng, K. T.K. Dung, C. Ahouada, Severin Lenaud, J. Welbeck, D. Dickinsonn, L. Zoungrana, A. Avihingsanon, T. T. Cao, V. K. Nguyen, Morten Sodemann, J. C. Dusingize, B. Okwara, C. Lewden, H. Traoré, Patrick MacPhail, David C Boettiger, G. Oka-Berete, H. K. Truong, F. Houngbé, Robin Wood, Venerandah Nhandu, J. C. Azani, G. Wandeler, K. L. Issouf, K. C. Anzan, Andrea L. Ciaranello, Awachana Jiamsakul, M. T. Ha, K. Brou, M. Maskew, L. Tossa-Bagnan, B. Zerbo, P. Pakpame, Xavier Anglaret, Jean W. Pape, J. B. Essanin, A. Petit, A. Kouakou, E. Rabourdin, Orasri Wittawatmongkol, Daniela Garone, S. El-Hadj Djibril, S. Duda, C. Twizere, K. C. Chan, Annie J. Sasco, N. Sanmeema, N. V. Lam, J. Conrad, Q. T. Du, P. Tharnprisan, Z. Yao, A. Djeha, Siriatou A. Koumakpai, Joachim Gnokoro, I. Hodonou, Sabine Hermans, Timothy R. Sterling, C. Nchot, D. Minta, E. Yunihastuti, T. F. Eboua, T. Cissé, Revathy Nallusamy, Jeffrey S. A. Stringer, Dabis F, F. Bohossou, Brian Eley, E. Traore, R. McKaig, Matthew Law, Manhattan Charurat, G. M. Kouakou, Madeleine Amorissani Folquet, A. Mandalakas, Sophie Desmonde, S. Eholié, J. K. Assouan, Andrew Boulle, Tuti Parwati Merati, A. Koko Lawson-Evi, Eugene Mutimura, C. A. Bosse, M Dosso, Fred Nalugoda, T. T. Pham, T. Udomphanit, H. L. Ha, N. Kancheya, N. Han, J. Sehonou, S. N. Kangah, R. Huebner, A. Gasser, C. Gilbert, Appolinaire Horo, J. C. Kouakou, D. Yé, P. Acquah, A. Héma, Pope Kosalaraksa, Hans Prozesky, J. James, Fatoumata Dicko, P. Cahn, Moussa Doumbia, I. Oliviera-Souto, Morna Cornell, Elenore Judy B. Uy, G. Hounhoui, J. E. Carter, V. A. Yao, Adrien Sawadogo, B. Petersen, S. E. Reid, B. Goka, G. Carriquiry, M. A. Davies, P. Nipathakosol, J. Le Carrou, M. L. Lindegren, H. Dior, P. Cegielski, E. Baramperanye, Mariam Sylla, Anders Fomsgaard, P. Braitstein, S. T. Coulibaly, D. D. Cuong, C. N'Diaye, M. Kone, Dewa Nyoman Wirawan, A. Gitembagara, Niaboula Koné, K. Ruxrungtham, R. Bognounou, Aissatou Touré, A. Ephoévi-gah, Alex Lund Laursen, and Y. Atakouma
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Male ,Questionnaires ,West African ,Pediatrics ,Asia Pacific ,Antitubercular Agents ,HIV Infections ,Drug resistance ,rifampicin ,South Africa ,drug resistant tuberculosis ,Surveys and Questionnaires ,Tuberculosis, Multidrug-Resistant ,Central Africa ,antiretrovirus agent ,Human immunodeficiency virus infected patient ,clinical practice ,microbial sensitivity test ,Infectious Diseases ,priority journal ,urban population ,Female ,anti human immunodeficiency virus agent ,supply and distribution ,medicine.drug ,Pulmonary and Respiratory Medicine ,Adult ,isoniazid ,medicine.medical_specialty ,Tuberculosis ,Asia ,phenotype ,Anti-HIV Agents ,Developing country ,MDR-TB ,Microbial Sensitivity Tests ,purl.org/pe-repo/ocde/ford#3.03.08 [https] ,preventive medicine ,Article ,South and Central America ,socioeconomics ,medicine ,Humans ,controlled study ,human ,rural population ,drug sensitivity ,Developing Countries ,Directly Observed Therapy ,Preventive healthcare ,ART programs ,Caribbean ,business.industry ,questionnaire ,Drug resistant tuberculosis ,developing country ,CD4 lymphocyte count ,Central africa ,Central America ,South America ,medicine.disease ,major clinical study ,Latin America ,purl.org/pe-repo/ocde/ford#3.02.07 [https] ,Africa ,world health organization ,tuberculostatic agent ,business ,Rifampicin - Abstract
SETTING: Drug resistance threatens tuberculosis (TB) control, particularly among human immunodeficiency virus (HIV) infected persons.OBJECTIVE: To describe practices in the prevention and management of drug-resistant TB under antiretroviral therapy (ART) programs in lower-income countries.DESIGN: We used online questionnaires to collect program-level data on 47 ART programs in Southern Africa (n = 14), East Africa (n = 8), West Africa (n = 7), Central Africa (n = 5), Latin America (n = 7) and the Asia-Pacific (n = 6 programs) in 2012. Patient-level data were collected on 1002 adult TB patients seen at 40 of the participating ART programs.RESULTS: Phenotypic drug susceptibility testing (DST) was available in 36 (77%) ART programs, but was only used for 22% of all TB patients. Molecular DST was available in 33 (70%) programs and was used in 23% of all TB patients. Twenty ART programs (43%) provided directly observed therapy (DOT) during the entire course of treatment, 16 (34%) during the intensive phase only, and 11 (23%) did not follow DOT. Fourteen (30%) ART programs reported no access to second-line anti-tuberculosis regimens; 18 (38%) reported TB drug shortages.CONCLUSIONS: Capacity to diagnose and treat drug-resistant TB was limited across ART programs in lower-income countries. DOT was not always implemented and drug supplies were regularly interrupted, which may contribute to the global emergence of drug resistance.
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- 2014
10. Tolérance, et acceptabilité de l’œsogastroduodénoscopie sans sédation à l’Hôpital d’Instruction des Armées de Cotonou
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J. Sehonou, N. Kodjoh, and B. Addra
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Gynecology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Sedation ,medicine ,Radiology, Nuclear Medicine and imaging ,Interventional radiology ,medicine.symptom ,Duodenoscopy ,business ,Abdominal surgery - Abstract
But Le but de cette etude etait d’evaluer la tolerance, le vecu et l’acceptabilite d’une gastroscopie standard sans sedation afin d’identifier les patients pouvant necessiter une anesthesie, dans un contexte de pays sous medicalise.
- Published
- 2005
11. Profil clinique et immunologique des patients infectés par le VIH dépistés à Cotonou, Bénin
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Séverin Anagonou, C Gbèdo, A. Azondekon, J. Vigan, F. Houngbè, D Kindé-Gazard, G Adè, D. M. Zannou, J. Sehonou, and F Atadokpèdé
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Gynecology ,medicine.medical_specialty ,Tuberculosis ,biology ,business.industry ,AIDS-Related Opportunistic Infections ,Respiratory disease ,biology.organism_classification ,medicine.disease ,Surgery ,Pneumonia ,Infectious Diseases ,Acquired immunodeficiency syndrome (AIDS) ,Prurigo ,medicine ,Sida ,business ,Mycosis - Abstract
Objectives. – This study had for aim to identify the clinical status and the level of immuno-deficiency of HIV-infected patients on their first visit. Methods. – One hundred and thirty-six HIV+ patients were prospectively evaluated from November 1, 2001 to May 31, 2002. Results. – One hundred and thirty-four were infected with HIV1 and two with HIV2. The mean age on the first consultation was 37 ± 2 years. The m/w sex ratio was 0.9. 46.3% were stage C. The main clinical symptoms were: weight loss (88%), fever (80%), cough (71%), diarrhea (51%). BMI was normal in 70% and KI ≥ 80% in 57% of the cases but immuno-deficiency was severe with CD4 cells count
- Published
- 2004
12. Phytobézoard gastrique favorisé par la pharmacopée traditionnelle africaine et les antisécrétoires: un cas
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J. Sehonou, N. Kodjoh, L. Houessinon, and B. Addra
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Gynecology ,medicine.medical_specialty ,Antisecretory drugs ,business.industry ,Phytobezoar ,medicine ,Radiology, Nuclear Medicine and imaging ,business ,Abdominal surgery - Abstract
Le phytobezoard gastrique est defini par la presence de vegetaux non digeres dans la cavite gastrique. Les facteurs favorisants sont mal connus. Nous rapportons le cas d’un phytobezoard gastrique chez un patient de 45 ans recu pour des douleurs abdominales et une alteration de l’etat general. La gastroscopie trouve une lesion tumorale d’allure maligne de la face posterieure de l’antre et une ulceration. Les biopsies de la lesion tumorale montrent un adenocarcinome. Le patient a recuse le traitement chirurgical propose mais a accepte la prise d’antisecretoires et la prise de medecine traditionnelle a base de plantes. Deux mois plus tard, une endoscopie de controle a revele la cicatrisation de la lesion ulceree, mais la persistance de la tumeur gastrique et surtout la presence d’un phytobezoard gastrique; la survenue de celle-ci est favorisee par l’association de plusieurs facteurs: adenocarcinome gastrique, traitement anti-secretoire et prise de medicaments traditionnels a base de plantes. Faut-il conseiller une baisse de la consommation de fibres alimentaires pendant toute la duree d’un traitement anti-secretoire gastrique? We report the case of a phytobezoar seen in a 45 year-old man admitted for acute abdominal pain and weight loss. A gastroscopy found a lesion suggesting a malignant tumour on the posterior wall of the antrum. Biopsies showed an adenocarcinoma. The patient denied surgery but accepted a medical treatment. He also took herbal traditional medicine. Two months later, he developed a phytobezoar. This uncommon lesion is favoured by several factors (hypo peristaltism due to the gastric tumour, and low gastric acidity (complication due to the administration of Protons Pump Inhibitors) and the use of traditional herbal medicine. Should African medical doctors recommend to their patients to stop herbal medicine or consumption of vegetables during a treatment with anti secretory drug?
- Published
- 2005
13. Prevalence of xerosis, eczema, and hair and nail abnormalities in PLWHA in Cotonou, Benin
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F, Atadokpede, H, Adegbidi, J J, Sehonou, C, Koudoukpo, D M, Houenassi, H G, Yedomon, and F, Do Ango-Padonou
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Adult ,Male ,Eczema ,Prevalence ,Benin ,Humans ,Nails, Malformed ,Female ,Skin Diseases ,Hair ,Retrospective Studies - Abstract
The objective of this investigation was to study the prevalence of xerosis, eczema, and hair and nail abnormalities in PLWHA in Cotonou.A retrospective study was performed on the records of PLWHA in Cotonou. All PLWHA with xerosis, eczema, or abnormal appendages were included.Forty-seven patients had xerosis or eczema. Their mean age was 38 years; the sex ratio 0.51 and the mean CD4 count 89 cells/mm(3). Twenty-three patients had xerosis, which affected the whole body (n = 20), lower limb (n = 2), limbs and trunk (n = 1), without gender difference. Twenty-four patients had eczema of which eight had both eczema and xerosis. Forty-two patients had abnormalities of the hair or nails. Their sex ratio was 0.80 and the mean CD4 count 110 cells/mm(3) . Nineteen patients had abnormalities of the hair and scalp: straight hair (n = 16), squamous lesions (n = 2), and folliculitis abscess (n = 1) with a male predominance. Twenty-three patients had nail dermatophytosis (n = 15), candidiasis (n = 7), and ingrowing nails (n = 1). These conditions affected more often women (74%) than men (26%).The prevalence of eczema and xerosis is low in our patients. Onychomycosis was the most frequent nail abnormality.
- Published
- 2012
14. [Cardiovascular risk evolution in patients treated for high blood pressure at the Armies Instruction's Hospital of Cotonou]
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D, Houénassi, Y, Tchabi, B, Awanou, J, Véhounkpé-Sacca, R, Akindès-Dossou Yovo, J, Sehonou, F, Atadokpédé, F, Hounto, R, Lawani, A, Gnangnon, M, d'Almeida-Massougbodji, and H, Agboton
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Adult ,Male ,Black People ,Middle Aged ,Hospitals, Military ,Cross-Sectional Studies ,Cardiovascular Diseases ,Risk Factors ,Cause of Death ,Hypertension ,Disease Progression ,Benin ,Humans ,Female ,Longitudinal Studies ,Hospitals, Teaching ,Developing Countries ,Antihypertensive Agents ,Retrospective Studies - Abstract
This study was initiated to determine the progression of the cardiovascular risk (CR) in a 5-years period for those who went through high blood pressure treatment. It is a retrospective and descriptive study over a period of 9 years. Were included in that category, African patients treated in that period of time and who at least benefited from a 5-years medical care period. The total CR was calculated afterwards, for the needs for the study, using the tables of Framingham. All the data were collected after the first evaluation then brought up to date at the terms of 1, 3 and 5 years and with a last consultation for the patients whose medical care follow-up exceeded 5 years. For the 103 patients who had complete data, the average age was of 49.11±8 and the sex ratio of 2. Among them 14 (13.6%) died of cardiovascular complications. Among the 89 remaining patients, the CR at the beginning was very high in a proportion of 10.1%, high in 49.4%, moderated in 22.5% and weak in 18%. The general evolution is characterized by a stability of the proportion of the moderated CR (20 - 23%) and high CR (43 - 50%) but a very important increase in the proportion of the very high CR (10 to 21%) to the detriment of the weak CR (18 to 10%). The analysis of the individual evolution reveals an improvement of the CR among 19 patients (21.3%), its stability among 39 patients (43.8%) and a worsening among 31 patients (34.8%). These data are confirmed in a widened population of 321 patients of which the less complete data allow an estimate of the CR.The cardiovascular risk is difficult to evaluate. It is badly controlled in the long run.
- Published
- 2009
15. [Mucocutaneous manifestations of human immunodeficiency virus infection in Cotonou, Benin]
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F, Atadokpede, H, Yedomon, H, Adegbidi, J J, Sehonou, A, Azondekon, and F, Do Ango-Padonou
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Adult ,Male ,Cross-Sectional Studies ,Benin ,Humans ,Female ,HIV Infections ,Skin Diseases ,CD4 Lymphocyte Count ,Retrospective Studies - Abstract
The purpose of this study was to describe mucocutaneous manifestations observed in persons living with human immunodeficiency virus (PLHIV) in Cotonou, Benin. A transverse retrospective study was carried out on the records of PLHIV who underwent follow-up at the Military Teaching Hospital in Cotonou from February 2002 to September 2005. The files of all eligible adult patients examined by dermatologists prior to initiation of antiretroviral treatment were reviewed. Dermatologic manifestations were defined as any cutaneous or cicatricial lesion of the skin. Data was analyzed using the EPI INFO software package. (version 6.0). A total of 152 patient files were included. The sex ratio was 1.10 with a female predominance. Mean age was 37.8 years. HIV1 was predominant (98%). Two-thirds of patients were as stage 3 according to the WHO classification. A total of 276 dermatologic manifestations were identified. The most common manifestations were buccopharyngeal candidiasis (24.6%), prurigo (20.6%), shingles (11.6%), and dermatophytosis (10.5%). The mean CD4 lymphocyte level was 106 cells/mm3. The CD4 level was below 100 cells/mm3 in 52% of cases involving candidiasis and 60% of cases involving prurigo. Dermatologic findings in this study were identical to those described in most studies from Africa and Asia. However the low prevalence of Koposi's sarcoma and seborrheic dermitits was surprising given the advanced stage of immunodepression in our patients. The most frequent mucocutaneous manifestations of HIV infection in Benin are infectious disease and prurigo.
- Published
- 2008
16. 724 OUTBREAK OF A NEW HEPATITIS C VIRUS SUBTYPE (SUBTYPE 1M) IN A HEMODIALYSIS UNIT: HOW NEW HCV GENOTYPES START THEIR SPREAD
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Laetitia Barbotte, Rozenn Brillet, Stéphane Chevaliez, Jean-Michel Pawlotsky, and J. Sehonou
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Hepatology ,business.industry ,Hepatitis C virus ,HCV genotypes ,medicine ,Outbreak ,medicine.disease_cause ,business ,Hemodialysis unit ,Virology - Published
- 2008
17. Hepatitis C virus diversity and treatment outcomes in Benin: a prospective cohort study.
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Ahovègbé L, Shah R, Kpossou AR, Davis C, Niebel M, Filipe A, Goldstein E, Alassan KS, Keke R, Sehonou J, Kodjoh N, Gbedo SE, Ray S, Wilkie C, Vattipally S, Tong L, Kamba PF, Gbenoudon SJ, Gunson R, Ogwang P, and Thomson EC
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- Humans, Benin epidemiology, Prospective Studies, Male, Female, Middle Aged, Adult, Treatment Outcome, Hepatitis C, Chronic drug therapy, Hepatitis C, Chronic virology, Hepatitis C, Chronic epidemiology, Sustained Virologic Response, Ribavirin therapeutic use, Drug Resistance, Viral genetics, Carbamates therapeutic use, Heterocyclic Compounds, 4 or More Rings therapeutic use, Fluorenes therapeutic use, Prevalence, Hepatitis C drug therapy, Hepatitis C epidemiology, Hepatitis C virology, Benzimidazoles, Drug Combinations, Hepacivirus genetics, Hepacivirus drug effects, Antiviral Agents therapeutic use, Genotype, Sofosbuvir therapeutic use, Phylogeny
- Abstract
Background: 10 million people are chronically infected with the hepatitis C virus (HCV) in sub-Saharan Africa. The assessment of viral genotypes and treatment response in this region is necessary to achieve the WHO target of worldwide elimination of viral hepatitis by 2030. We aimed to investigate the prevalence of HCV genotypes and outcomes of treatment with direct-acting antiviral agents in Benin, a country with a national HCV seroprevalence of 4%., Methods: This prospective cohort study was conducted at two referral hospitals in Benin. Individuals were eligible for inclusion if they were seropositive for HCV and willing to consent to participation in the study; exclusion criteria were an inability to give consent or incarceration. Viraemia was confirmed by PCR. The primary outcomes were to identify HCV genotypes and measure sustained virological response rates 12 weeks after completion of treatment (SVR12) with a 12-week course of sofosbuvir-velpatasvir or sofosbuvir-ledipasvir, with or without ribavirin. We conducted phylogenetic and resistance analyses after the next-generation sequencing of samples with a cycle threshold (Ct) value of 30 or fewer cycles. The in-vitro efficacy of NS5A inhibitors was tested using a subgenomic replicon assay., Findings: Between June 2, 2019, and Dec 30, 2020, 148 individuals were screened for eligibility, of whom 100 were recruited prospectively to the study. Plasma samples from 79 (79%) of the 100 participants were positive for HCV by PCR. At the time of the study, 52 (66%) of 79 patients had completed treatment, with an SVR12 rate of 94% (49 of 52). 57 (72%) of 79 samples had a Ct value of 30 or fewer cycles and were suitable for whole-genome sequencing, from which we characterised 29 (51%) samples as genotype 1 and 28 (49%) as genotype 2. Three new genotype 1 subtypes (1q, 1r, and 1s) and one new genotype 2 subtype (2xa) were identified. The most commonly detected subtype was 2d (12 [21%] of 57 samples), followed by 1s (eight [14%]), 1r (five [9%]), 1b (four [7%]), 1q (three [5%]), 2xa (three [5%]), and 2b (two [3%]). 20 samples (11 genotype 2 and nine genotype 1) were unassigned new singleton lineages. 53 (93%) of 57 sequenced samples had at least two resistance-associated substitutions within the NS5A gene. Subtype 2d was associated with a lower-than-expected SVR12 rate (eight [80%] of ten patients). For one patient, with subtype 2b, treatment was not successful., Interpretation: This study revealed a high SVR rate in Benin among individuals treated for HCV with sofosbuvir-velpatasvir, including those with highly diverse viral genotypes. Further studies of treatment effectiveness in genotypes 2d and 2b are indicated., Funding: Medical Research Council, Wellcome, Global Challenges Research Fund, Academy of Medical Sciences, and PHARMBIOTRAC., Competing Interests: Declaration of interests ECT declares funding from the Medical Research Council (MRC) for the MRC Preparedness Platform and the MRC World Class Labs award 2023/24, and her institution has received research funds from Novavax, AstraZeneca, the University of Oxford, and the University of Southampton. She has acted as an external consultant for WHO (HCV and Ebola virus), is the Chair of the BHIVA hepatitis subcommittee, and is a member of UK Health Security Agency technical groups. All other authors declare no competing interests., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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18. Challenge of gastro-intestinal stromal tumor management in low-income countries: example of Benin.
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Gbessi DG, Gnangnon FHR, Kpossou AR, Gbetchedji PP, Seidou F, Imorou Souaïbou Y, Attolou SGR, Lawani I, Laleye MC, Gangbo F, Dossou FM, Sehonou J, and Mehinto DK
- Subjects
- Female, Male, Humans, Middle Aged, Imatinib Mesylate therapeutic use, Benin epidemiology, Retrospective Studies, Cross-Sectional Studies, Gastrointestinal Stromal Tumors epidemiology, Gastrointestinal Stromal Tumors therapy
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Background: GISTs are rare tumors but the most frequent mesenchymal tumors of the digestive tract. Diagnosis and treatment are challenging in low-income countries due to relatively poor access to immunohistochemistry and targeted therapy. In Africa, there are few studies about it. Imatinib, an oral targeted therapy, has been available in Benin since 2010 and free since 2016. This study describes the diagnosis and therapeutic management of GIST in Cotonou, Benin., Methods: This is a descriptive cross-sectional study, with retrospective data collection over a 10-year period from 2010 to 2020, focused on patients with histological confirmed gastro-intestinal stromal tumor (GIST). Cases were identified using the registry database and the archival files of the Hubert Koutoukou Maga National University Hospital of Cotonou (CNHU-HKM)., Results: Fifteen GISTs were identified during the study period. The median age was 52 and the sex ratio was 2:1 (10 males and 5 females). The most frequent symptom was abdominal pain (n = 12). Delay in care seeking after onset of symptoms ranged from 24 h to 15 years. The most common site for GISTs was the stomach (n = 8). The median tumor size was 11 cm and the majority (n=10) was metastatic or locally advanced at the time of diagnosis. The tumors were often spindle-shaped at histology (n = 13) and the majority expressed KIT (n = 14). Most of the tumors (n = 12) were at high risk of recurrence according to the Joensuu scoring system. The availability of imatinib has improved the outcome of GIST with response in all cases it was used in neoadjuvant setting (n = 7)., Conclusion: GISTs are rare tumors and preferentially affect the stomach in Cotonou). Most of the tumors were large, unresectable at the time of diagnosis and at high risk of recurrence. Access to imatinib has revolutionized the management of those tumors in our country., (© 2022. The Author(s).)
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- 2022
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19. [Multifocal tuberculosis simulating multimetastatic colon cancer in an immunocompetent black African patient: a case report].
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Kpossou AR, Adjadohoun S, Diallo K, Badarou S, Ngamo G, Sokpon CNM, Vignon RK, Takin R, Yekpè P, Sehonou J, and Biaou O
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- Abdominal Pain etiology, Benin, Black People, Colonic Neoplasms pathology, Colonoscopy, Fatal Outcome, Humans, Immunocompetence, Male, Malnutrition diagnosis, Nutritional Support methods, Tomography, X-Ray Computed, Tuberculosis therapy, Young Adult, Antitubercular Agents administration & dosage, Colonic Neoplasms diagnosis, Tuberculosis diagnosis
- Abstract
Multifocal tuberculosis is rare in immunocompetent subjects. It is characterized by the involvement of at least two extra-pulmonary sites, associated or not with lung disease. It is often difficult to diagnose. We here report a case of multifocal tuberculosis in a non-immunocompromised black African subject at the Hubert Koutoukou Maga National Hospital and University Center (CNHU-HKM) in Cotonou, Benin. The study involved a 23-year-old man, with no particular previous history, admitted with diffuse abdominal pain associated with alteration of general state. Clinical examination showed severe malnutrition and medium-volume ascites. Imaging tests (chest X-ray, ultrasound and computed tomography (CT) scan) showed multiple lung, liver, pancreatic, bone, lymph nodes and colic lesions suggesting multimetastatic tumor. Colonoscopy then showed budding lesion of the cecum. GeneXpert test showed Koch´s bacilli. The anatomo-pathological examination of colic biopsies and GeneXpert sputum test confirmed multifocal tuberculosis. The patient received antituberculosis treatment and nutritional support. However he died. Multifocal tuberculosis is a serious disease that is difficult to diagnose. Then it is frequently mis-diagnosed in tropical areas, especially when it occurs in immunocompetent patients., Competing Interests: Les auteurs ne déclarent aucun conflit d´intérêts., (Copyright: Aboudou Raïmi Kpossou et al.)
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- 2021
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20. [Cancers of the pancreas at the National Hospital and University Center of Cotonou: epidemiological, diagnostic, therapeutic and prognostic features].
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Kpossou AR, Gbessi DG, Gnangnon FHR, Ba Boukari MM, Vignon RK, Sokpon CNDM, and Sehonou J
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- Adenocarcinoma pathology, Adenocarcinoma therapy, Adult, Aged, Aged, 80 and over, Antineoplastic Agents administration & dosage, Benin, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Neoplasm Staging, Pancreatic Neoplasms pathology, Pancreatic Neoplasms therapy, Prognosis, Prospective Studies, Retrospective Studies, Survival Rate, Adenocarcinoma epidemiology, Hospitalization statistics & numerical data, Palliative Care methods, Pancreatic Neoplasms epidemiology
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Introduction: cancer is a major cause of death in the world. The purpose of this study is to evaluate the epidemiological, clinical, therapeutic and prognostic features of cancers of the pancreas (CP) at the National Hospital and University Center of Cotonou., Methods: we conducted a cross-sectional descriptive and analytical study with a prospective and retrospective data collection over a period of ten years, from 1 October 2009 to 31 October 2019., Results: out of 15.102 hospitalizations, we identified 72 cases of CP, reflecting a hospitalization rate of 0.5%. The average age of patients was 59 years. The sex-ratio (H/F) was 1.5. The main reason for consultation was abdominal pain. More than half (51.4%) of patients had metastatic tumor at the time of diagnosis. Histological evidence of adenocarcinoma was only reported in 15.1% of cases. The rate of operable patients was 37.5% while the rate of resectable patients was 2.7%. Palliative chemotherapy was given to 13.9% of patients. The average cost of treatment was 955.882,4 FCFA (23.9 times the Guaranteed Interprofessional Minimum Wage in Benin). Median overall survival was 6 months. Mortality rate was 86.9% (53/61), survival rate at one year was 31.4%, and zero at five years. Palliative surgery (p = 0.021) and chemotherapy (p = 0.023) improved patient survival., Conclusion: cancer of the pancreas, due to its non-specific signs and insidious outcome, is often diagnosed at a late stage. A metastatic tumor and the limited individual and institutional therapeutic possibilities lead to more pejorative prognosis., Competing Interests: Les auteurs ne déclarent aucun conflit d'intérêts., (Copyright: Aboudou Raïmi Kpossou et al.)
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- 2021
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21. [Prevention and factors associated with anti-HCV carriage in pregnant women living in Cotonou].
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Aboubakar M, Kpossou AR, Glago BRGH, Aguiah AG, Mboreha ZH, and Sehonou J
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- Adolescent, Adult, Benin, Carrier State virology, Cross-Sectional Studies, Female, Hepatitis C epidemiology, Humans, Infectious Disease Transmission, Vertical prevention & control, Middle Aged, Pregnancy, Pregnancy Complications, Infectious virology, Prenatal Care methods, Prevalence, Risk Factors, Young Adult, Carrier State diagnosis, Hepatitis C diagnosis, Hepatitis C Antibodies blood, Pregnancy Complications, Infectious diagnosis
- Abstract
Introduction: hepatitis C is an infection which can be passed from mother to child. The purpose of this study was to investigate the prevalence of colonization by anti-HCV antibodies in pregnant women living in Cotonou and to identify factors associated with it., Methods: we conducted a cross-sectional study of 253 pregnant women admitted for prenatal care in four major maternity hospitals in Cotonou (Benin) from 01/06/2018 to 01/09/2018. Anti-HCV antibodies were detected using rapid diagnostic tests. A venous blood sample was collected from pregnant women tested positive for anti-HCV before confirmatory serological tests and screening tests for gestational diabetes., Results: the prevalence of anti-HCV antibodies was 1.2% (3/253 pregnant women). Factors associated with HCV carriage couldn't be identified given the low number of positive cases. However, pregnant women who were carriers of hepatitis C antibodies had higher mean age (32 ± 3) compared to the remainder of the population (29.58 ± 5.5). Potential risk factors for HCV infection were scarifications, piercing, tattooing, sharing of manicure equipment, a history of surgery and blood transfusions. The prevalence of gestational diabetes in our study population was 7.9% (20/253). No association was found between gestational diabetes and hepatitis C., Conclusion: the prevalence of anti-HCV antibodies in pregnant women living in Cotonou was low. A national-level study is needed to identify factors associated with this infection., Competing Interests: Les auteurs ne déclarent aucun conflit d´intérêt., (Copyright: Moufalilou Aboubakar et al.)
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- 2020
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22. [Clinical profile and factors associated with irritable bowel syndrome among medical students in Cotonou (Benin)].
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Sehonou J and Dodo LRS
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- Absenteeism, Adolescent, Adult, Anxiety epidemiology, Benin epidemiology, Cross-Sectional Studies, Female, Humans, Male, Prevalence, Risk Factors, Students, Medical psychology, Young Adult, Education, Medical, Irritable Bowel Syndrome epidemiology, Stress, Psychological epidemiology, Students, Medical statistics & numerical data
- Abstract
Introduction: irritable bowel syndrome (IBS) is a common disorder that often results in general medicine and gastroenterology consultations. This study aims to determine IBS prevalence, to describe its clinical features, to determine its associated factors as well as its impact on the education among medical students in Cotonou., Methods: We conducted a cross-sectional, descriptive and analytical study on medical students over the period 1 August-29 September 2017. The diagnostic criteria were: Rome IV, Bristol scale, Cungi scale and HADS score. Data analysis was performed using SPSS 20.0 software., Results: Out of 315 students included in the study, 44 (14%) had IBS. The factors associated with IBS were female gender (OR [CI 95%] = 2.4 [1.2 - 4.7]; p = 0.00), regular consumption of fatty foods (OR [CI 95%] = 2.0 [1.1 - 3.9]; p = 0.03), high to severe levels of stress (OR [CI 95%] = 2.2 [1.1 - 4.7]; p= 0.02) and moderate to severe state of anxiety (OR [CI 95%] = 1.9 [0.9 - 3.6]; p= 0.04). IBS-related absenteeism was rare (1 case; 2.3%)., Conclusion: IBS is common among medical students in Cotonou. The identified modifiable factors associated with IBS were stress, anxiety and regular consumption of fatty foods. No appreciable impact on the education was reported., Competing Interests: Les auteurs ne déclarent aucun conflit d'intérêts.
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- 2018
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23. [Cardiovascular risk evolution in patients treated for high blood pressure at the Armies Instruction's Hospital of Cotonou].
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Houénassi D, Tchabi Y, Awanou B, Véhounkpé-Sacca J, Akindès-Dossou Yovo R, Sehonou J, Atadokpédé F, Hounto F, Lawani R, Gnangnon A, d'Almeida-Massougbodji M, and Agboton H
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- Adult, Antihypertensive Agents therapeutic use, Benin, Cardiovascular Diseases mortality, Cardiovascular Diseases prevention & control, Cause of Death, Cross-Sectional Studies, Disease Progression, Female, Hospitals, Military, Hospitals, Teaching, Humans, Hypertension drug therapy, Hypertension mortality, Longitudinal Studies, Male, Middle Aged, Retrospective Studies, Risk Factors, Black People, Cardiovascular Diseases diagnosis, Cardiovascular Diseases epidemiology, Developing Countries, Hypertension diagnosis, Hypertension epidemiology
- Abstract
Unlabelled: This study was initiated to determine the progression of the cardiovascular risk (CR) in a 5-years period for those who went through high blood pressure treatment. It is a retrospective and descriptive study over a period of 9 years. Were included in that category, African patients treated in that period of time and who at least benefited from a 5-years medical care period. The total CR was calculated afterwards, for the needs for the study, using the tables of Framingham. All the data were collected after the first evaluation then brought up to date at the terms of 1, 3 and 5 years and with a last consultation for the patients whose medical care follow-up exceeded 5 years. For the 103 patients who had complete data, the average age was of 49.11±8 and the sex ratio of 2. Among them 14 (13.6%) died of cardiovascular complications. Among the 89 remaining patients, the CR at the beginning was very high in a proportion of 10.1%, high in 49.4%, moderated in 22.5% and weak in 18%. The general evolution is characterized by a stability of the proportion of the moderated CR (20 - 23%) and high CR (43 - 50%) but a very important increase in the proportion of the very high CR (10 to 21%) to the detriment of the weak CR (18 to 10%). The analysis of the individual evolution reveals an improvement of the CR among 19 patients (21.3%), its stability among 39 patients (43.8%) and a worsening among 31 patients (34.8%). These data are confirmed in a widened population of 321 patients of which the less complete data allow an estimate of the CR., Conclusion: The cardiovascular risk is difficult to evaluate. It is badly controlled in the long run., (Copyright © 2011 Elsevier Masson SAS. All rights reserved.)
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- 2013
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24. [Liver cirrhosis in Cotonou, Republic of Benin: clinical aspects and factors related to death].
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Sehonou J, Kodjoh N, Sake K, and Mouala C
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- Alcoholism complications, Benin epidemiology, Female, Hepatitis B complications, Hospital Mortality, Humans, Liver Cirrhosis etiology, Male, Middle Aged, Retrospective Studies, Sex Factors, Liver Cirrhosis mortality
- Abstract
Unlabelled: Infection by hepatitis B virus is the main cause of liver cirrhosis in Africa. The purpose of this retrospective study was to evaluate clinical and epidemiological features as well as factors related to death in cirrhosis patients admitted to the National University Hospital in Cotonou, Benin., Methods: The files of patients admitted from January 1 to December 31, 2004 were reviewed., Results: Out of the 230 useable files reviewed, a total of 52 involved patients were admitted for liver cirrhosis. The male/female sex ratio was 2.25 and mean age was 49 years. The proportion of unemployed and salaried patients was 42.3% and 28.8% respectively. Hepatitis B and alcohol consumption were the main etiological factors: 53.3% and 23.2% respectively. The main reasons for hospitalization were asthenia in 73% of cases, abdominal pain in 57%, and digestive bleeding in 21%. The revealing manifestations were ascitis (75%), jaundice (71.7%), and hepatocellular carcinoma (42.3%). Higher risk for in-hospital death (42.3%) was correlated with male gender, salaried employment, and presentation with jaundice, ascitis, or hepatocellular carcinoma. The risk of death during hospitalization was higher for patients who were of male gender, working as salaried employees and admitted for the first time with jaundice, ascitis, or hepatocellular carcinoma., Conclusion: A program for mass vaccination of children against hepatitis B virus is needed to prevent cirrhosis and hepatocellular carcinoma. A campaign against alcohol abuse could reduce cirrhosis due to alcohol consumption.
- Published
- 2010
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