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Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries
- Source :
- Ballif, M, Nhandu, V, Wood, R, Dusingize, J C, Carter, E J, Cortes, C P, McGowan, C C, Diero, L, Graber, C, Renner, L, Hawerlander, D, Kiertiburanakul, S, Du, Q T, Sterling, T R, Egger, M, Fenner, L, International epidemiological Databases to Evaluate AIDS (IeDEA) & Erikstrup, C 2014, ' Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries ', International Journal of Tuberculosis and Lung Disease, vol. 18, no. 11, pp. 1327-36 . https://doi.org/10.5588/ijtld.14.0106, Ballif, M, Nhandu, V, Wood, R, Dusingize, J C, Carter, E J, Cortes, C P, McGowan, C C, Diero, L, Graber, C, Renner, L, Hawerlander, D, Kiertiburanakul, S, Du, Q T, Sterling, T R, Egger, M, Fenner, L, International epidemiological Databases to Evaluate AIDS (IeDEA) & Sodemann, M 2014, ' Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries ', International Journal of Tuberculosis and Lung Disease, vol. 18, no. 11, pp. 1327-1336 . https://doi.org/10.5588/ijtld.14.0106
- Publication Year :
- 2014
-
Abstract
- SETTING: Drug resistance threatens tuberculosis (TB) control, particularly among human immunodeficiency virus (HIV) infected persons.OBJECTIVE: To describe practices in the prevention and management of drug-resistant TB under antiretroviral therapy (ART) programs in lower-income countries.DESIGN: We used online questionnaires to collect program-level data on 47 ART programs in Southern Africa (n = 14), East Africa (n = 8), West Africa (n = 7), Central Africa (n = 5), Latin America (n = 7) and the Asia-Pacific (n = 6 programs) in 2012. Patient-level data were collected on 1002 adult TB patients seen at 40 of the participating ART programs.RESULTS: Phenotypic drug susceptibility testing (DST) was available in 36 (77%) ART programs, but was only used for 22% of all TB patients. Molecular DST was available in 33 (70%) programs and was used in 23% of all TB patients. Twenty ART programs (43%) provided directly observed therapy (DOT) during the entire course of treatment, 16 (34%) during the intensive phase only, and 11 (23%) did not follow DOT. Fourteen (30%) ART programs reported no access to second-line anti-tuberculosis regimens; 18 (38%) reported TB drug shortages.CONCLUSIONS: Capacity to diagnose and treat drug-resistant TB was limited across ART programs in lower-income countries. DOT was not always implemented and drug supplies were regularly interrupted, which may contribute to the global emergence of drug resistance.
- Subjects :
- Male
Questionnaires
West African
Pediatrics
Asia Pacific
Antitubercular Agents
HIV Infections
Drug resistance
rifampicin
South Africa
drug resistant tuberculosis
Surveys and Questionnaires
Tuberculosis, Multidrug-Resistant
Central Africa
antiretrovirus agent
Human immunodeficiency virus infected patient
clinical practice
microbial sensitivity test
Infectious Diseases
priority journal
urban population
Female
anti human immunodeficiency virus agent
supply and distribution
medicine.drug
Pulmonary and Respiratory Medicine
Adult
isoniazid
medicine.medical_specialty
Tuberculosis
Asia
phenotype
Anti-HIV Agents
Developing country
MDR-TB
Microbial Sensitivity Tests
purl.org/pe-repo/ocde/ford#3.03.08 [https]
preventive medicine
Article
South and Central America
socioeconomics
medicine
Humans
controlled study
human
rural population
drug sensitivity
Developing Countries
Directly Observed Therapy
Preventive healthcare
ART programs
Caribbean
business.industry
questionnaire
Drug resistant tuberculosis
developing country
CD4 lymphocyte count
Central africa
Central America
South America
medicine.disease
major clinical study
Latin America
purl.org/pe-repo/ocde/ford#3.02.07 [https]
Africa
world health organization
tuberculostatic agent
business
Rifampicin
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Ballif, M, Nhandu, V, Wood, R, Dusingize, J C, Carter, E J, Cortes, C P, McGowan, C C, Diero, L, Graber, C, Renner, L, Hawerlander, D, Kiertiburanakul, S, Du, Q T, Sterling, T R, Egger, M, Fenner, L, International epidemiological Databases to Evaluate AIDS (IeDEA) & Erikstrup, C 2014, ' Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries ', International Journal of Tuberculosis and Lung Disease, vol. 18, no. 11, pp. 1327-36 . https://doi.org/10.5588/ijtld.14.0106, Ballif, M, Nhandu, V, Wood, R, Dusingize, J C, Carter, E J, Cortes, C P, McGowan, C C, Diero, L, Graber, C, Renner, L, Hawerlander, D, Kiertiburanakul, S, Du, Q T, Sterling, T R, Egger, M, Fenner, L, International epidemiological Databases to Evaluate AIDS (IeDEA) & Sodemann, M 2014, ' Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries ', International Journal of Tuberculosis and Lung Disease, vol. 18, no. 11, pp. 1327-1336 . https://doi.org/10.5588/ijtld.14.0106
- Accession number :
- edsair.doi.dedup.....fdb8db8f5cf7326f1c19549bd7bd5972