297 results on '"Hongzhi Yang"'
Search Results
2. Correlation between functional drainage and survival in malignant biliary obstruction after percutaneous biliary drainage
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Hongzhi Yang, Qiujian Qin, yulin Tang, and Wenliang Zhu
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Malignant obstructive jaundice ,Percutaneous transhepatic biliary drainage ,Advanced cancer ,Survival ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Purpose: Malignant biliary obstruction (MBO) is common in patients with advanced malignant tumors, leading to poor prognosis and hindering antitumor therapy. The purpose of our study was to assess the survival outcomes for patients under therapy after percutaneous transhepatic biliary drainage (PTBD) and identify prognostic factors associated with survival in patients with MBO. Methods: From July 2010 to February 2021, 269 patients with MBO secondary to malignant tumor were divided into two groups (functional success and non-functional success). Survival time and prognostic factors were analyzed by Kaplan–Meier curves and the Cox model. Results: The overall median survival time after PTBD was 4.6 months (95 % IC:3.9–5.3). The 3- and 6-month survival rates were 68.0 % and 38.7 %, respectively. The median survival improved from 3.2 months to 8.4 months when the procedure achieved functional success. Multivariate analysis demonstrated that functionally successful drainage and antitumor treatment after PTBD were independent positive prognostic factors, but the total bilirubin after drainage and tumor size were independent negative predictive values. Conclusions: Functionally successful drainage could prolong survival time in patients with malignant biliary obstruction. Palliative care after drainage can prolong patient survival and improve their quality of life.
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- 2024
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3. Short‐term traffic travel time forecasting using ensemble approach based on long short‐term memory networks
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Xingli Jia, Wuxiao Zhou, Hongzhi Yang, Shuangqing Li, and Xingpeng Chen
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data analysis ,intelligent transportation systems ,learning (artificial intelligence) ,transportation ,Transportation engineering ,TA1001-1280 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Abstract To enhance the control effect of intelligent transportation system (ITS) of expressway, avoid blind travel causing traffic congestion, improve road capacity, and achieve the purpose of smooth and efficient operation of the network, 3σ criterion and 2σ cycle removal criterion were used to eliminate the abnormal data of travel time. Thereafter, a combined prediction model of Long Short‐Term Memory (LSTM) based on the complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) algorithm and attention mechanism is proposed. Travel time data, collected from the real world, is decomposed into several Intrinsic Mode Functions (IMFs) and a residue with the CEEMDAN. Then, the decomposed sub‐sequence is predicted and the final prediction result is obtained by comprehensive superposition. The results indicate that: the CEEMDAN algorithm has significantly improved the prediction performance. Compared with the AT‐LSTM model, mean absolute percentage error (MAPE) is reduced by 10.75%, 24.84%, 31.80%, 24.98%, 14.29%, and 31.42% when the time window was 3, 6, 9, 12, 15, and 18, respectively, in the dataset of Yaxi expressway. In the dataset of Chengnan expressway, the number of error points with MAPE greater than 40% is significantly reduced after the adoption of the LSTM model. After the introduction of CEEMDAN algorithm, the error at each time point is controlled within 30%. The proposed model controls the error at each time point within 25%. In different datasets, the proposed model has better prediction ability for highly non‐linear travel time, and can better capture the trend abrupt characteristics of rush hour traffic flow.
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- 2023
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4. The renal artery-aorta angle associated with renal artery plaque: a retrospective analysis based on CT
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Hongzhi Yang and Ruwu Yang
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Renal artery plaque ,Renal artery and vein ,320-row CT ,Medical technology ,R855-855.5 - Abstract
Abstract Purpose To investigate the relationship between renal artery anatomical configuration and renal artery plaque (RAP) based on 320-row CT. Methods The abdominal contrast-enhanced CT data from 210 patients was retrospectively analyzed. Among 210 patients, there were 118 patients with RAP and 92 patients with no RAP. The anatomical parameters between lesion group and control group were compared and analyzed by using t-test, χ2-test and logistic regression analysis. Results (1) There were statistical differences on age, hypertension, diabetes, hypertriglyceridemia and hypercholesterolemia between lesion group and control group. (2) The differences on the distribution and type and of RAP between lesion group and control group were statistically significant. The most common position was the proximal, and the most common type was calcified plaque. (3)There were significant statistical differences on the proximal diameter of renal artery and renal artery-aorta angle A between lesion group and control group. The differences on the other anatomical factors between two groups were not statistically significant. (4) The result of logistic regression analysis showed that right RAP was related to age, hypertension and right renal artery angle A (the AUC of ROC = 0.82), and left RAP was related to high serum cholesterol, age and left renal artery angle A(the AUC of ROC = 0.83). (5) The RAP was associated with renal artery-aorta angle A, but the differences on distribution, type stability of RAP between R1 (L1) group and R2 (L2) group were not statistically significant. Conclusions The RAP was associated with age, hypertension, hypercholesterolemia and renal artery-aorta angle A. Adults which had the greater renal artery-aorta angle A and the other above risk factors may be at increased risk for RAP.
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- 2023
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5. Detection of copy number variations based on a local distance using next-generation sequencing data
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Guojun Liu, Hongzhi Yang, and Zongzhen He
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copy number variation ,next-generation sequencing ,read depth ,local distance ,normal distribution ,Genetics ,QH426-470 - Abstract
As one of the main types of structural variation in the human genome, copy number variation (CNV) plays an important role in the occurrence and development of human cancers. Next-generation sequencing (NGS) technology can provide base-level resolution, which provides favorable conditions for the accurate detection of CNVs. However, it is still a very challenging task to accurately detect CNVs from cancer samples with different purity and low sequencing coverage. Local distance-based CNV detection (LDCNV), an innovative computational approach to predict CNVs using NGS data, is proposed in this work. LDCNV calculates the average distance between each read depth (RD) and its k nearest neighbors (KNNs) to define the distance of KNNs of each RD, and the average distance between the KNNs for each RD to define their internal distance. Based on the above definitions, a local distance score is constructed using the ratio between the distance of KNNs and the internal distance of KNNs for each RD. The local distance scores are used to fit a normal distribution to evaluate the significance level of each RDS, and then use the hypothesis test method to predict the CNVs. The performance of the proposed method is verified with simulated and real data and compared with several popular methods. The experimental results show that the proposed method is superior to various other techniques. Therefore, the proposed method can be helpful for cancer diagnosis and targeted drug development.
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- 2023
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6. Yao-Shan of traditional Chinese medicine: an old story for metabolic health
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Shuangling Yang, Hongzhi Yang, and Yaxing Zhang
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Chinese Yao-Shan ,diabetes ,nonalcoholic fatty liver diseases ,hyperuricemia ,gout ,sexual dysfunction ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Type 2 diabetes mellitus, nonalcoholic fatty liver disease (NAFLD), cardio-cerebrovascular diseases (CCVDs), hyperuricemia and gout, and metabolic-related sexual dysfunction are metabolic diseases that affect human health in modern society. Scientists have made great efforts to investigate metabolic diseases using cell models in vitro or animal models in the past. However, the findings from cells or animals are difficult to translate into clinical applications due to factors such as the in vitro and in vivo differences; the differences in anatomy, physiology, and genetics between humans and animals; and the differences in microbiome–host interaction. The Chinese have extensively used the medicated diet of traditional Chinese medicine (TCM) (also named as Yao-Shan of TCM, Chinese Yao-Shan et al.) to maintain or improve cardiometabolic health for more than 2,200 years. These ancient classic diets of TCM are essential summaries of long-term life and clinical practices. Over the past 5 years, our group has made every effort to collect and sort out the classic Yao-Shan of TCM from the ancient TCM literature since Spring and Autumn and Warring States Period, especially these are involved in the prevention and treatment of metabolic diseases, such as diabetes, NAFLD, CCVDs, hyperuricemia and gout, and sexual dysfunction. Here, we summarized and discussed the classic Yao-Shan of TCM for metabolic diseases according to the time recorded in the ancient literature, and revised the Latin names of the raw materials in these Yao-Shan of TCM. Moreover, the modern medicine evidences of some Yao-Shan of TCM on metabolic diseases have also been summarized and emphasized in here. However, the exact composition (in terms of ratios), preparation process, and dosage of many Yao-Shan are not standardized, and their main active ingredients are vague. Uncovering the mystery of Yao-Shan of TCM through modern biological and chemical strategies will help us open a door, which is ancient but now looks new, to modulate metabolic homeostasis and diseases.
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- 2023
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7. Experimental characterization and molecular modeling of kerogen in Silurian deep gas shale from southern Sichuan Basin, China
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Shan Huang, Xinhua Ma, Hongzhi Yang, Jianfa Wu, Jian Zhang, Shengxian Zhao, Deliang Zhang, Chunyu Ren, and Liang Huang
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Deep shale ,Kerogen ,Molecular model ,Experimental characterization ,Sorption ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
A representative molecular model of kerogen is the prerequisite to the study on molecular interaction of fluid molecules with organic nanopores of shale. The molecular kerogen model in Silurian deep gas shale from southern China remains to be developed. In this work, the chemical structure of the targeted deep shale kerogen is characterized by organic geochemical measurements. The derived structural parameters are utilized to build the molecular structure of the kerogen unit. The kerogen unit shows a good representation of realistic kerogen structure in shale reservoir in terms of carbon skeleton, heteroatomic compositions and groups. The kerogen matrix and a extended kerogen slit model are constructed based on the kerogen unit, which match well with the experimental results in matrix density and kerogen porosity, respectively. The kerogen matrix is overall disordered with gentle stacking of polyaromatic fragments, due to the bendable aliphatic linkages and large-size aromatic units. The kerogen nanopores are not saturated with methane at deep shale reservoir conditions. At high pressure, the absolute adsorption tends to reach a maximum, while the excess adsorption shows a decreasing trend. The effect of pressure on the dissolved gas density is not pronounced. The generated kerogen model can serve as a starting point for further theoretical investigations on fluid storage and transport in organic nanopores of deep shale reservoir at microscopic scale.
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- 2022
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8. Research of influencing factors on permeability for carbonate rocks based on LBM simulation: A case study of low-permeability gas reservoir of Sinian Dengying Formation in Sichuan Basin
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Shan Yang, Hongzhi Yang, Xian Peng, Xuemei Lan, Yongfei Yang, Yi Zhao, Kai Zhang, and Hongde Chen
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low-permeability ,pore-throat characteristic in pore-scale ,fluid transport in porous media ,Sichuan Basin ,digital rock ,Science - Abstract
Instruction: Due to the declining production rate of conventional natural gas reservoir and the rising demand for natural gas resources, conventional natural gas resources cannot satisfy the needs of economic development. Unconventional gas resource is considered to be the most promising energy supplement, therefore it is an inevitable trend to explore and develop unconventional oil and gas resources such as low permeability reservoirs. At present, the carbonate gas reservoirs in the high permeability area of Sichuan Basin have been almost fully developed, while the remaining gas reservoirs in the low permeability area are not well developed. However, the key factors for effectively enhancing gas recovery rate in different types of low permeability reservoirs are not the same. Even gas reservoirs with the same macroscopic geological characteristics will show different development characteristics through the production processes.Method: In order to analyze the factors affecting the effective production rate of low-permeability gas reservoirs, it is necessary to conduct research from the microscopic perspective, to reveal the effective production conditions of natural gas in low-permeability reservoirs. In this study, low-permeability carbonate samples of Sinian Dengying Formation from Sichuan Basin were taken. Micro-CT scanning technology was used to obtain core images for the carbonate rocks, and the digital carbonate core models at microscopic scale were reconstructed. Based on the reconstructed carbonate digital core models, LBM method was applied to obtain the absolute permeability of the core models.Results: The results imply that the porosity, pore area fraction, throat area fraction, mean throat length, shape factor, coordination number and tortuosity are the factors affecting the absolute permeability of carbonate rocks.Discussion: Subsequently, the relationship between different pore structure parameters and absolute permeability was obtained by multi-parameter fitting method, which provided a new research method for directly predicting the absolute permeability of carbonate rocks by using pore structure parameters.
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- 2023
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9. Micropore Structure of Deep Shales from the Wufeng–Longmaxi Formations, Southern Sichuan Basin, China: Insight into the Vertical Heterogeneity and Controlling Factors
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Hongzhi Yang, Shengxian Zhao, Bo Li, Yong Liu, Majia Zheng, Jian Zhang, Yongyang Liu, Gaoxiang Wang, Meixuan Yin, and Lieyan Cao
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southern Sichuan Basin ,Longmaxi Formation ,deep shale ,pore structure ,influencing factors ,Mineralogy ,QE351-399.2 - Abstract
The microscopic pore throat structure of shale reservoir rocks directly affects the reservoir seepage capacity. The occurrence and flow channels of shale gas are mainly micron–nanometer pore throats. Therefore, to clarify the microstructural characteristics and influencing factors of the deep organic-rich shales, a study is conducted on the marine shale from the Upper Silurian to Lower Ordovician Wufeng–Longmaxi Formation in the southern Sichuan Basin. Petrographic lithofacies division is carried out in combination with petro-mineralogical characteristics, and a high-resolution scanning electron microscope, low-temperature nitrogen and low-temperature carbon dioxide adsorption, and micron-computed tomography are used to characterize the mineral composition and pore structure qualitatively and quantitatively, upon which the influencing factors of the microstructure are further analyzed. The results show that with the increase in burial depth, the total organic carbon content and siliceous mineral content decrease in the Wufeng formation to Long-11 subsection deep shale, while clay mineral content increases, which corresponds to the change in sedimentary environment from anoxic to oxidizing environment. Unexpectedly, the total pore volume of deep shale does not decrease with the increase in burial depth but increases first and then decreases. Using total organic carbon (TOC), siliceous mineral content showed a good correlation with total pore volume and specific surface area, with correlation coefficients greater than 0.7, confirming the predominant role of these two factors in controlling the pore structure of deep shales. This is mainly because the Longmaxi shale is already in the late diagenetic stage, and organic matter pores are generated in large quantities. Clay minerals have a negative correlation with the total pore volume of shale, and the correlation coefficient is 0.7591. It could be that clay minerals are much more flexible and are easily deformed to block the pores under compaction. In addition, the longitudinal heterogeneity of the deep shale reservoir structure in southern Sichuan is also controlled by the thermal effect of the Emei mantle plume on hydrocarbon generation of organic matter and the development of natural microfractures promoted by multistage tectonic movement. Overall, the complex microstructure in the deep shales of the Longmaxi Formation in the southern Sichuan Basin is jointly controlled by multiple effects, and the results of this research provide strong support for the benefit development of deep shale gas in southern Sichuan Basin.
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- 2023
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10. Screening of heat stress-regulating active fractions in mung beans
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Yuchao Feng, Xia Fan, Dengcheng Suo, Shu Zhang, Yantao Ma, Haoyu Wang, Xin Guan, Hongzhi Yang, and Changyuan Wang
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heat stress ,polyphenols ,cells ,HSP70 ,mung bean ,UHPLC-QE-HF-HRMS ,Nutrition. Foods and food supply ,TX341-641 - Abstract
IntroductionHeat stress caused by high temperatures has important adverse effects on the safety and health status of humans and animals, and dietary interventions to alleviate heat stress in daily life are highly feasible.MethodsIn this study, the components of mung bean that have heat stress-regulating effects were characterized by in vitro antioxidant indicators and heat stress cell models.ResultsAs a result, 15 target monomeric polyphenol fractions were identified based on untargeted analysis on an ultra performance liquid chromatography coupled with high field quadrupole orbit high resolution mass spectrometry (UHPLC-QE-HF-HRMS) platform and available reports. The results of DPPH and ABTS radical scavenging showed that mung bean polyphenols (crude extract) and 15 monomeric polyphenols had better antioxidant activity, followed by oil and mung bean peptides, while protein and polysaccharides had relatively poor antioxidant activity. Qualitative and quantitative assays for 20 polyphenols (15 polyphenols and 5 isomers) were then established based on platform targets. Vitexin, orientin, and caffeic acid were identified as monomeric polyphenols for heat stress control in mung beans based on their content. Finally, mild (39°C), moderate (41°C), and severe (43°C) heat stress models were successfully constructed based on mouse intestinal epithelial Mode-k cells and human colorectal adenocarcinoma Caco-2 cell lines, all with an optimal heat stress modeling time of 6 h. Screening of mung bean fractions using HSP70 mRNA content, a key indicator of heat stress. As a result, HSP70 mRNA content was significantly up-regulated by different levels of heat stress in both cell models. The addition of mung bean polyphenols (crude extract), vitexin, orientin, and caffeic acid resulted in significant down-regulation of HSP70 mRNA content, and the higher the level of heat stress, the more significant the regulation effect, with orientin having the best effect. Mung bean proteins, peptides, polysaccharides, oils and mung bean soup resulted in increased or no change in HSP70 mRNA levels after most heat stresses.DiscussionThe polyphenols were shown to be the main heat stress regulating components in mung bean. The results of the validation experiments confirm that the above three monomeric polyphenols may be the main heat stress regulating substances in mung bean. The role of polyphenols in the regulation of heat stress is closely linked to their antioxidant properties.
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- 2023
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11. Failure mechanism and interfacial diffusion behavior of Ru-doped NiAlHf coatings at 1200 °C
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Hongzhi Yang, Xiaoya Li, Jianpeng Zou, Qian Shi, Mingjiang Dai, Changguang Deng, and Pengbo Lyu
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NiAlHf/Ru coatings failure mechanism ,Diffusion behavior ,TCP phases ,Interfacial microstructure evolution ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Ru-doped NiAlHf coatings were deposited on Ni-based single crystal substrate by arc ion plating technology. The failure mechanism and interfacial diffusion behavior were comparatively investigated with NiAlHf coating using scanning electron microscopy, electron probe micro-analyzer, and transmission electron microscopy. The results indicated that microstructure evolution of oxide scale induced by element diffusion process significantly affected oxidation resistance of NiAlHf/Ru coatings, resulting in formation of cracks and voids, thereby accelerating failure process. The precipitates in interdiffusion zone and secondary reaction zone of the substrate initiated by interfacial element diffusion were P phase and σ phase, respectively. And the discrepancy in content was elucidated from the perspective of thermodynamics and kinetics. Besides, microstructural evolution between NiAlHf/Ru coatings and substrate was also deliberated. The research could not only provide profound understanding of NiAlHf/Ru coatings failure mechanism, but also had significant guidance for suppressing precipitation of topological close-packed phases and facilitating development of single crystal Ni-based superalloys.
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- 2023
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12. A shortest path-based approach for copy number variation detection from next-generation sequencing data
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Guojun Liu, Hongzhi Yang, and Xiguo Yuan
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copy number variation ,next-generation sequencing data ,k nearest neighbors ,shortest path ,read depth ,Genetics ,QH426-470 - Abstract
Copy number variation (CNV) is one of the main structural variations in the human genome and accounts for a considerable proportion of variations. As CNVs can directly or indirectly cause cancer, mental illness, and genetic disease in humans, their effective detection in humans is of great interest in the fields of oncogene discovery, clinical decision-making, bioinformatics, and drug discovery. The advent of next-generation sequencing data makes CNV detection possible, and a large number of CNV detection tools are based on next-generation sequencing data. Due to the complexity (e.g., bias, noise, alignment errors) of next-generation sequencing data and CNV structures, the accuracy of existing methods in detecting CNVs remains low. In this work, we design a new CNV detection approach, called shortest path-based Copy number variation (SPCNV), to improve the detection accuracy of CNVs. SPCNV calculates the k nearest neighbors of each read depth and defines the shortest path, shortest path relation, and shortest path cost sets based on which further calculates the mean shortest path cost of each read depth and its k nearest neighbors. We utilize the ratio between the mean shortest path cost for each read depth and the mean of the mean shortest path cost of its k nearest neighbors to construct a relative shortest path score formula that is able to determine a score for each read depth. Based on the score profile, a boxplot is then applied to predict CNVs. The performance of the proposed method is verified by simulation data experiments and compared against several popular methods of the same type. Experimental results show that the proposed method achieves the best balance between recall and precision in each set of simulated samples. To further verify the performance of the proposed method in real application scenarios, we then select real sample data from the 1,000 Genomes Project to conduct experiments. The proposed method achieves the best F1-scores in almost all samples. Therefore, the proposed method can be used as a more reliable tool for the routine detection of CNVs.
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- 2023
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13. Analysis on the Difference of Daohuaxiang Rice Metabolites in Different Producing Areas
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Yuchao FENG, Hongzhi YANG, Yu AN, Shu ZHANG, Yanan SHENG, and Changyuan WANG
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origin ,metabonomics ,rice ,gas chromatography-mass spectrometry (gc-ms) ,difference mechanism ,Food processing and manufacture ,TP368-456 - Abstract
Based on the metabolomic technique of GC-MS, the metabolites and metabolic differential mechanism of rice from Ning'an and Wuchang city were studied. SIMCA and R software were used for multivariate statistical analysis of the data. The results showed that the place of production had an influence on the quantity, content, type and proportion of the metabolites of Daohuaxiang rice. A total of 127 metabolites were identified in rice samples from the two regions. A total of 22 different metabolites were screened out through the analysis of the differences between the samples from the two regions. And it was found that the origin had the most significant influence on the contents of fatty acids and their derivatives. The results of metabolic pathway analysis showed that the main mechanism of rice metabolism difference in different producing areas was the metabolism of fatty acids. Linoleic acid, palmitic acid and fumaric acid were the three key metabolites. And the difference of metabolites type and content was related to rice quality. The research analyzes the different mechanisms of rice metabolism in different producing areas from the aspect of metabolite composition, which can provide theoretical support for the regional differentiation of rice production and the traceability of agricultural products.
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- 2022
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14. Mechanism of Curcumin and/or Aerobic Exercise Improving Pyroptosis in Myocardium of Hyperlipidemic Rats
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Yongqiang MAO, Qiyun ZHOU, Xinyue ZHANG, and Hongzhi YANG
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curcumin ,aerobic exercise ,hyperlipidemia ,rat ,pyroptosis ,Food processing and manufacture ,TP368-456 - Abstract
To study the mechanism of curcumin and/or aerobic exercise improving pyroptosis in myocardium of hyperlipidemic rats. Fifty 5-week-old male SD rats were randomly divided into normal diet control group (RDC), high fat diet control group (HDC), high fat diet with curcumin group (HDCC), high fat diet with aerobic exercise group (HDM), high fat diet with curcumin and aerobic exercise group (HDCM), ten in each group. From the third week, group HDCC and HDCM were injected intragastrically with curcumin at 400 g/(kg·d), and the other groups were given an equal volume of 0.5% sodium carboxymethylcellulose. Group HDM and HDCM performed aerobic exercise intervention, and the other groups did not. Twenty-four hours after the end of 6-week-intervention, the myocardial microstructure in each group was observed, blood and myocardium related biochemical indicators were tested. The results showed that, serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), HDC were significantly higher than RDC (P
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- 2022
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15. Tectonic Transition from Passive to Active Continental Margin of Nenjiang Ocean: Insight from the Middle Devonian-Early Carboniferous Granitic Rocks in Northern Great Xing’an Range, NE China
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Li Zhang, Yongfei Ma, Yongjiang Liu, Sihua Yuan, Hongzhi Yang, Weimin Li, Chenyue Liang, and Zhiqiang Feng
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central Asian orogenic belt ,hegenshan-heihe suture ,Nenjiang Ocean ,middle Devonian-Early Carboniferous ,granitic rocks ,zircon U-Pb age ,Mineralogy ,QE351-399.2 - Abstract
Northeast China occupies the majority of the eastern Central Asian Orogenic Belt, which mainly consists of continental blocks and accretionary terranes. The Devonian was a tectonic quiet period in the NE China region due to a lack of tectono-magmatism, but the tectonic background of this period has been unclear, especially for the Hegenshan-Heihe Suture between Xing’an and Songliao accretionary terranes, which represents the Paleozoic Nenjiang Ocean (a branch ocean of the eastern Paleo-Asian Ocean). Here we report granitic rocks from the Woluohe area, Northern Great Xing’an Range, NE China, to constrain the tectonic process of the transition from the Devonian quiet period to the Early Carboniferous active tectonic period. Three granitic rock samples produce zircon U-Pb ages of 389 Ma, 368 Ma, and 351 Ma, belonging to the Middle and Late Devonian and Early Carboniferous, respectively. They have high Si, Al, K, and Na contents, but with low Mg, Fe, and Ti contents, together with positive Hf isotopic features and low molar Al2O3/(MgO+FeOT) ratios, we suggest that they were derived from partial melting of lower crustal igneous rocks. Meanwhile, the narrow major element variation at odd with the fractionation process and their negative Nb and Ta anomalies imply the obvious contribution of crustal. Comprehensive tectonic setting analysis shows all samples are in calc-alkali magmatic series with rightward fractionated REE and trace element patterns that are enriched in LREE and LILE and depleted in HREE and HFS, indicating a subduction-related magmatic arc setting. Considering the regional tectonic setting and the small scale of the Devonian plutons, we suggest a limited subduction tectonic setting during the quiet period of the northern Great Xing’an Range, which might indicate the beginning of an initial northwestward subduction of the Nenjiang Oceanic lithosphere beneath the Xing’an Accretionary Terrane in the Middle Devonian, accelerated subduction in the Late Devonian, and bidirectional subduction in the Early Carboniferous.
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- 2023
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16. Feasibility-Based Design Model For Road Vertical Alignment
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Hongzhi Yang, Xuliang Guo, Zhenfeng Wang, and Shanshan Hu
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road design ,vertical alignment ,feasibility-based design model ,design constraints ,feasible region ,Highway engineering. Roads and pavements ,TE1-450 ,Bridge engineering ,TG1-470 - Abstract
Road vertical alignment design is a multi-objective design problem that needs to consider multiple constraints. Intelligent design based on optimization algorithms cannot wholly solve problems, such as multi-objective, uncertainty, and constraint dynamics. The article proposes a model of dynamically transforming design constraints into feasible regions as the design develops, to provide decision information before design actions rather than performing constraint evaluation after the design that reduces the empirical estimation. The design actions are divided into new design actions and modifying design actions, and corresponding feasible regions derived from constraints of design specifications and control elevations are established, respectively. Geometrical equations and program algorithms of feasible regions are described in the graphic environment, which is applied to the vertical alignment design to improve the design efficiency and decision-making level.
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- 2021
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17. The Use of Communication Strategies by Second Language Learners of Chinese in a Virtual Reality Learning Environment
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Hongzhi Yang, Linda Tsung, and Lu Cao
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History of scholarship and learning. The humanities ,AZ20-999 ,Social Sciences - Abstract
Virtual reality (VR) for Language learning has been shown effective in improving students’ communication skills. However very few studies reveal the communication strategies students used in communicating in a VR environment, especially in learning Chinese as a foreign or second language (CFL/CSL). In this pilot study, a prototype Virtual Experiential Language Learning Environment (VELLE) was used to provide immersive learning experiences in developing CFL students’ communication strategies. Productive Failure was employed as an instructional approach to support the learning design. The participants were six CFL students learning in an Australian university. The main data sources included audio recordings of the students’ communication in VR and interview data. The findings showed that participants’ use of various types of communication strategies was influenced by the VELLE and Productive Failure design. In particular, the use of L1 in the problem-solving phase enriched the participants’ learning opportunities and all participants used a lesser number of resource deficit-related strategies after the instruction. Second, Students reported enhanced engagement in language use in the VR context.
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- 2022
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18. Educational entrepreneurship in Australian community languages schools: An analysis of ethnic principals’ experience and practice
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Hui-Zhong Shen and Hongzhi Yang
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educational entrepreneurship traits ,community languages school ,leadership and management ,Education (General) ,L7-991 - Abstract
Educational entrepreneurship refers to the competence of educational entrepreneurs in making changes and taking initiatives in vision-driven innovation and value creation. Research of educational entrepreneurship needs further investigation, especially in the context of complementary education. This paper explores the educational entrepreneurship of three principals working in the context of community language schools (CLSs) in Australia. Using a set of educational entrepreneurship traits as an analytical tool, this study conducts a detailed qualitative analysis of the interviews and reflective journals of three CLS principals to reveal their educational entrepreneurial traits displayed in the process of establishing and running the CLSs. Findings indicate that these principals display multiple educational entrepreneurial traits in combination when dealing with challenges encountered in their individual context. The empirical data enriches the understanding of the distinctive features of educational entrepreneurship, especially the influence of prior experience. The findings reveal some key traits and practices of educational entrepreneurship amongst CLS principals in the Australian context. This study provides context-specific empirical evidence to better understand the nature and features of educational entrepreneurship. The findings highlight the need for more research and explicit training of entrepreneurial skills for school leaders in non-mainstream schools.
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- 2022
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19. Noble Gases Therapy in Cardiocerebrovascular Diseases: The Novel Stars?
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Jiongshan Zhang, Wei Liu, Mingmin Bi, Jinwen Xu, Hongzhi Yang, and Yaxing Zhang
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helium (He) ,neon (Ne) ,argon (Ar) ,krypton (Kr) ,xenon (Xe) ,cardiovascular diseases ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Cardiocerebrovascular diseases (CCVDs) are the leading cause of death worldwide; therefore, to deeply explore the pathogenesis of CCVDs and to find the cheap and efficient strategies to prevent and treat CCVDs, these are of great clinical and social significance. The discovery of nitric oxide (NO), as one of the endothelium-derived relaxing factors and its successful utilization in clinical practice for CCVDs, provides new ideas for us to develop drugs for CCVDs: “gas medicine” or “medical gases.” The endogenous gas molecules such as carbon monoxide (CO), hydrogen sulfide (H2S), sulfur dioxide (SO2), methane (CH4), and hydrogen (H2) have essential biological effects on modulating cardiocerebrovascular homeostasis and CCVDs. Moreover, it has been shown that noble gas atoms such as helium (He), neon (Ne), argon (Ar), krypton (Kr), and xenon (Xe) display strong cytoprotective effects and therefore, act as the exogenous pharmacologic preventive and therapeutic agents for CCVDs. Mechanistically, besides the competitive inhibition of N-methyl-D-aspartate (NMDA) receptor in nervous system by xenon, the key and common mechanisms of noble gases are involved in modulation of cell death and inflammatory or immune signals. Moreover, gases interaction and reduction in oxidative stress are emerging as the novel biological mechanisms of noble gases. Therefore, to investigate the precise actions of noble gases on redox signals, gases interaction, different cell death forms, and the emerging field of gasoimmunology, which focus on the effects of gas atoms/molecules on innate immune signaling or immune cells under both the homeostatic and perturbed conditions, these will help us to uncover the mystery of noble gases in modulating CCVDs.
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- 2022
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20. Automatic History Matching of Parent-Child Wells in Shale Gas Reservoirs with Complex Fracture Hits
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Mingyi Gao, Wen Zhou, Jian Zhang, Cheng Chang, Jianfa Wu, Hongzhi Yang, Shengxian Zhao, Chuxi Liu, Wei Yu, and Hao Xu
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Geology ,QE1-996.5 - Abstract
AbstractIt is excessively crucial for performing production match of parent-child wells automatically by using assisted history matching approach, especially considering the interwell interference scenario. We explored a new EDFM-AI (Embedded Discrete Facture Model-Artificial Intelligence) workflow by taking into account the multiple uncertainty parameters that were composed of fracture height, fracture half-length, fracture conductivity, fracture water saturation, fracture cluster efficiency, and natural fracture conductivity. The history matching algorithm implemented in this study is advanced machine learning model called XGBoost. It could overcome the issue that the proxy model is always imprecise due to the limited training sample data. Specifically, we established a field-scale reservoir model that includes parent-child shale gas wells with fracture hits in the Sichuan basin. By using this sophisticated workflow, two wells’ history matching results are excellent in terms of the inversed solution of the hydraulic fracture properties and natural fracture properties. And then, we perform the production forecasting for parent and child wells, respectively. Consequently, the results show that the best match value for estimated ultimate recovery (EUR) of parent well is 287.4 million cubic meters whereas the best match value for EUR of child well is 187.6 million cubic meters. The reliable reason is that effective fractured area of parent well is larger than that of child well. Besides, the natural fractures have a significant impact on the performance of shale gas wells with fracture hits observed, especially in the short-term production period.
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- 2022
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21. Geohazards regionalization along highways in Shandong Province, China
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Hongzhi Yang, Yue Zhao, and Qianfang Cheng
- Subjects
geohazards ,highway ,comprehensive geohazard index ,intensity index ,sensitivity index ,getis-ord gi* statistic ,incomplete additive language matrix ,two-level regionalization ,Environmental technology. Sanitary engineering ,TD1-1066 ,Environmental sciences ,GE1-350 ,Risk in industry. Risk management ,HD61 - Abstract
The disturbance of the highway construction to the terrain and the natural environmental factors are the main causes of the geohazards along the highway. We collected geohazards along the highway in Shandong Province and put forward the comprehensive geohazard index to reflect the risk of geohazards along the highway. The index consists of an intensity index describing the development of geohazards and a sensitivity index describing the potential risk of geohazards. The article uses an incomplete additive language matrix to calculate the weight of each index and factor. Based on the Getis-Ord Gi* statistic tool, the spatial distribution of landslides and collapses, debris flows, ground collapses, and unstable slopes are analyzed, and the geohazard intensity index is calculated by spatial superposition. The relationship between slope gradient, rainfall, vegetation coverage, rock type and geohazards is analyzed, and the geohazard sensitivity index is calculated by spatial superposition. Based on the comprehensive geohazard index and geomorphological characteristics, Shandong Province is divided into 4 geohazard first-level regions and 11 geohazard second-level regions, providing a basis for highway planning and construction.
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- 2020
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22. Helium Protects Against Lipopolysaccharide-Induced Cardiac Dysfunction in Mice via Suppressing Toll-Like Receptor 4-Nuclear Factor κB-Tumor Necrosis Factor-Alpha/ Interleukin-18 Signaling
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Yaxing Zhang, Jiongshan Zhang, Kangquan Xu, Zifeng Chen, Xiaodan Xu, Jingting Xu, Shuhui Zheng, Min Dai, and Hongzhi Yang
- Subjects
helium ,interleukin-18 ,lipopolysaccharide ,nuclear factor-κb ,septic cardiomyopathy ,toll-like receptor 4 ,tumor necrosis factor-alpha ,Physiology ,QP1-981 - Abstract
The nonanesthetic noble gas helium (He) can protect many organs against ischemia and reperfusion injury, such as liver and heart. However, the role of He on cardiac dysfunction during sepsis is not clear. In this study, we established a lipopolysaccharide (LPS)-induced cardiac dysfunction mouse model to examine the influence of He on the impaired cardiac function, and further investigated the possible innate immune mechanisms that may be involved. LPS induced left ventricular dysfunction and cavity enlargement, as indicated by decreased percent ejection fraction, percent fractional shortening, left ventricular anterior wall thickness in systole, and left ventricular posterior wall thickness in systole, while increased left ventricular end-systolic diameter and left ventricular end-systolic volume. He improved the impaired left ventricular function and cavity enlargement in a dose-dependent manner, and it was beneficial at 1.0 mL/100 g. Mechanistically, He inhibited toll-like receptor 4 (TLR4) expression, reduced the phosphorylation of nuclear factor κB (NF-κB), and subsequently alleviated tumor necrosis factor-alpha (TNF-α) and interleukin-18 (IL-18) expression in heart. Therefore, He protects against LPS-induced cardiac dysfunction in mice partially via inhibiting myocardial TLR4-NF-κB-TNF-α/IL-18 signaling.
- Published
- 2020
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23. Preservice EAL/D Teachers' Relational Agency during Online Paired Practicum
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Hongzhi Yang and Andrew S. Ross
- Abstract
There is scant research on preservice English as an additional language or dialect (EAL/D) teachers' paired practicums in an online context. Underpinned by Cultural Historical Activity Theory, this paper explores how preservice EAL/D teachers exercise their relational agency during online paired practicums. Data were collected from five preservice EAL/D teachers' weekly journals written during their paired practicums and interviews after they completed their paired practicums. Following the key components of relational agency, the thematic analysis highlights the dialectical relationship between preservice teachers' relational agency and different types of collaboration, evidenced by the formation of mutual objects, tool mediation, and shared expertise. This paper provides new insight into how preservice teachers' knowledge, especially related to the affordances of technology, may be expanded and mediated by collaboration.
- Published
- 2023
24. Paleoproterozoic Mineralization of the Lijiapuzi Gold Deposit in the Liaodong Peninsula, NE China: Constraints from 40Ar-39Ar Age, S-Pb Isotopes, and In Situ Analyses
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Yan Zhao, Peng Zhang, Hongzhi Yang, Linlin Kou, Zhongwei Bi, Zhongzhu Yang, and Jiang Chen
- Subjects
40Ar/39Ar dating ,in situ analysis ,S-Pb isotopes ,gold mineralization ,Jiao-Liao-Ji orogeny ,the Lijiapuzi deposit ,Mineralogy ,QE351-399.2 - Abstract
A Paleoproterozoic 40Ar/39Ar age, interpreted as the gold metallogenic epoch of the Lijiapuzi deposit in NE China, is reported in this paper. The ore body of this deposit is hosted in the marbles and schists of the Paleoproterozoic Dashiqiao Formation and exhibits parallel development to the foliation of the country rocks. Coexisting auriferous pyrite and tremolite can be observed both in the field and under a microscope, revealing the presence of hydrothermal activity in the deposit. The δ34S composition of the auriferous pyrite varies from +8‰ to +12.3‰, indicating a sedimentary origin. The auriferous pyrite and host marble have similar Pb isotopic ratios, indicating the contribution of Paleoproterozoic sediments to gold mineralization. Furthermore, in situ S and trace element analyses of the auriferous pyrite reveal that the main gold mineralization stage was Py2, which coexists with radial tremolite. 40Ar/39Ar dating of these tremolite samples yields a plateau age of ~1851.23 Ma, with similar isochronal and inverse isochronal ages. The Paleoproterozoic gold metallogenesis, together with the contemporary Pb-Zn, boron, graphite, and magnetite mineralization, constitute an important mineralogenetic series during the evolution of the Jiao-Liao-Ji orogeny in the Liaodong Peninsula.
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- 2022
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25. Using Productive Failure to Learn Genetics in a Game-Based Environment
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Lu Cao, Polly K. Lai, and Hongzhi Yang
- Abstract
This study explored the use of an innovative instructional approach called Productive Failure (PF) to design an educational game and its support. The study then examined the effects of two different types of instruction--PF vs. Direct Instruction (DI)--on learning genetics and relevant mathematical knowledge in a Game-Based Learning (GBL) environment. One hundred fifty-seven Year 10 students from two high schools participated in two quasi-experimental studies. The participants were divided into two treatment groups: one group learned targeted concepts using PF with GBL (PF-GBL), while the other group learned the same concepts using DI with GBL (DI-GBL). The results of the first study indicated that the PF-GBL group showed significantly higher learning gains than the DI-GBL group on explanatory genetics knowledge. In the second study, no group difference was found between the PF-GBL group and the DI-GBL group on learning genetics and relevant mathematical knowledge. Implications of findings, limitations, and future research are discussed.
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- 2024
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26. Effect of Thermal Processing on the Metabolic Components of Black Beans on Ultra-High-Performance Liquid Chromatography Coupled with High-Field Quadrupole-Orbitrap High-Resolution Mass Spectrometry
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Yuchao Feng, Xia Fan, Shu Zhang, Miao Yu, Tong Wu, Ying Liang, Changyuan Wang, and Hongzhi Yang
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metabolic components ,hot working ,UHPLC-QE-MS ,black beans ,Organic chemistry ,QD241-441 - Abstract
An ultra-high-performance liquid chromatography coupled with high-field quadrupole-orbitrap mass spectrometry (UHPLC-QE-MS) histological platform was used to analyze the effects of two thermal processing methods (cooking and steaming) on the nutritional metabolic components of black beans. Black beans had the most amino acids, followed by lipids and polyphenols, and more sugars. Multivariate statistical analysis indicated that heat processing significantly affected the metabolic component content in black beans, with effects varying among different components. Polyphenols, especially flavonoids and isoflavones, were highly susceptible. A total of 197 and 210 differential metabolites were identified in both raw black beans and cooked and steamed black beans, respectively. Cooking reduced the cumulative content of amino acids, lipids, polyphenols, sugars, and nucleosides, whereas steaming reduced amino acid and lipid content, slightly increased polyphenol content, and significantly increased sugar and nucleoside content. Our results indicated that metabolic components were better retained during steaming than cooking. Heat treatment had the greatest impact on amino acids, followed by polyphenols, fatty acids, sugars, and vitamins, indicating that cooking promotes the transformation of most substances and the synthesis of a few. The results of this study provide a basis for further research and development of nutritional products using black beans.
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- 2022
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27. The Application of Integrated Assisted History Matching and Embedded Discrete Fracture Model Workflow for Well Spacing Optimization in Shale Gas Reservoirs with Complex Natural Fractures
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Qiwei Li, Jianfa Wu, Cheng Chang, Hongzhi Yang, Chuxi Liu, Wei Yu, Kamy Sepehrnoori, and Jijun Miao
- Subjects
Geology ,QE1-996.5 - Abstract
An appropriate well spacing plan is critical for the economic development of shale gas reservoirs. The biggest challenge for well spacing optimization is interpreting the subsurface uncertainties associated with hydraulic and natural fractures. Another challenge is the existence of complex natural fractures. This work applied an integrated well spacing optimization workflow in shale gas reservoirs of the Sichuan Basin in China with both hydraulic and natural fractures. The workflow consists of five components: data preparation, reservoir simulation, estimated ultimate recovery (EUR) analysis, economic calculation, and well spacing optimization. Firstly, the multiple realizations of thirteen uncertain parameters of matrix and fractures, including matrix permeability and porosity, three relative permeability parameters, hydraulic fracture height, half-length, width, conductivity, water saturation, and natural fracture number, length, and conductivity, were captured by the assisted history matching (AHM). The fractures were modeled by the embedded discrete fracture model (EDFM) accurately and efficiently. Then, 84 AHM solutions combining with five well spacing scenarios from 517 ft to 1550 ft would generate 420 simulation cases. After reservoir simulation of these 420 cases, we forecasted the long-term gas production for each well spacing scenario. Gas EUR degradation and well interference would imply the critical well spacing. The net present value (NPV) for all scenarios would be calculated and trained by K-nearest neighbors (KNN) proxy to better understand the relationship between well spacing and NPV. In this study, the optimum well spacing was determined as 793 ft, corresponding with a maximum NPV of 18 million USD, with the contribution of hydraulic fractures and natural fractures.
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- 2021
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28. Migrasome and Tetraspanins in Vascular Homeostasis: Concept, Present, and Future
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Yaxing Zhang, Jing Wang, Yungang Ding, Jiongshan Zhang, Yan Xu, Jingting Xu, Shuhui Zheng, and Hongzhi Yang
- Subjects
cell migration ,migrasome ,migracytosis ,tetraspanins ,vascular homeostasis ,Biology (General) ,QH301-705.5 - Abstract
Cell migration plays a critical role in vascular homeostasis. Under noxious stimuli, endothelial cells (ECs) migration always contributes to vascular repair, while enhanced migration of vascular smooth muscle cells (VSMCs) will lead to pathological vascular remodeling. Moreover, vascular activities are involved in communication between ECs and VSMCs, between ECs and immune cells, et al. Recently, Ma et al. (2015) discovered a novel migration-dependent organelle “migrasome,” which mediated release of cytoplasmic contents, and this process was defined as “migracytosis.” The formation of migrasome is precisely regulated by tetraspanins (TSPANs), cholesterol and integrins. Migrasomes can be taken up by neighboring cells, and migrasomes are distributed in many kinds of cells and tissues, such as in blood vessel, human serum, and in ischemic brain of human and mouse. In addition, the migrasome elements TSPANs are wildly expressed in cardiovascular system. Therefore, TSPANs, migrasomes and migracytosis might play essential roles in regulating vascular homeostasis. In this review, we will discuss the discoveries of migration-dependent migrasome and migracytosis, migrasome formation, the basic differences between migrasomes and exosomes, the distributions and functions of migrasome, the functions of migrasome elements TSPANs in vascular biology, and discuss the possible roles of migrasomes and migracytosis in vascular homeostasis.
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- 2020
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29. Hydrogen: An Endogenous Regulator of Liver Homeostasis
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Yaxing Zhang, Jingting Xu, and Hongzhi Yang
- Subjects
gut microbiota ,oxidative stress ,inflammation ,apoptosis ,glucose homeostasis ,lipids homeostasis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Basic and clinical studies have shown that hydrogen (H2), the lightest gas in the air, has significant biological effects of anti-oxidation, anti-inflammation, and anti-apoptosis. The mammalian cells have no abilities to produce H2 due to lack of the expression of hydrogenase. The endogenous H2 in human body is mainly produced by anaerobic bacteria, such as Firmicutes and Bacteroides, in gut and other organs through the reversible oxidation reaction of 2 H+ + 2 e- ⇌ H2. Supplement of exogenous H2 can improve many kinds of liver injuries, modulate glucose and lipids metabolism in animal models or in human beings. Moreover, hepatic glycogen has strong ability to accumulate H2, thus, among the organs examined, liver has the highest concentration of H2 after supplement of exogenous H2 by various strategies in vivo. The inadequate production of endogenous H2 play essential roles in brain, heart, and liver disorders, while enhanced endogenous H2 production may improve hepatitis, hepatic ischemia and reperfusion injury, liver regeneration, and hepatic steatosis. Therefore, the endogenous H2 may play essential roles in maintaining liver homeostasis.
- Published
- 2020
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30. Phase Noise Influence in a Dual-Frequency Laser Phase-Shift Range Finder
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Hongzhi Yang, Changming Zhao, Haiyang Zhang, Suhui Yang, and Xinyuan Zheng
- Subjects
Remote sensing and sensors ,optoelectronics. ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
The influence of phase noise in a dual-frequency laser phase-shift range finder is theoretically and experimentally investigated. The proposed range finder is based on the use of a coherent dual-frequency laser and direct detection of the backscattered laser. The effects of laser phase noise and noise from an acousto-optic frequency shifter (AOFS) on the dual-frequency laser phase-shift range finder are analyzed. Expressions of the power spectral density and the phase noise of the dual-frequency laser beat note are deduced. In addition, we find that noise from the AOFS has a considerable impact on beat note noise conversion. The theoretical results can be used to estimate the influence of laser phase noise, noise induced by the AOFS and delay length in the dual-frequency laser range finder. An experiment involving the dual-frequency laser range finder is performed on outdoor targets at a distance of 200 m, and the phase jitter observed in the experiment is in good agreement with the model of beat note phase noise.
- Published
- 2018
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31. Mineral Composition of Prospective Section of Wufeng-Longmaxi Shale in Luzhou Shale Play, Sichuan Basin
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Hongzhi Yang, Xuewen Shi, Chao Luo, Wei Wu, Yi Li, Yifan He, Kesu Zhong, and Jianguo Wu
- Subjects
shale ,Wufeng-Longmaxi ,mineral ,Luzhou play ,deep-buried shale gas ,Sichuan Basin ,Mineralogy ,QE351-399.2 - Abstract
Currently, Luzhou in the Sichuan Basin is a focal point for shale-gas exploration and development in China. However, a lack of detailed research on the mineral composition of the Wufeng Formation-Longmaxi Formation (WF-LF) shale is hindering the extraction of deep-buried shale gas in the Luzhou shale play. Herein, a field emission scanning electron microscope (FESEM) equipped with the Advanced Mineral Identification and Characterization System (AMICS) software was employed to analyze the mineral composition of the WF-LF shale from six wells in Luzhou. Quartz was the dominant mineral type, (16.9–87.21%, average 51.33%), followed by illite, calcite, dolomite, and pyrite. Our study revealed that (1) quartz content showed a moderate positive correlation with the total organic carbon (TOC) content, indicating that the quartz found in the shale is mostly of biological origin; and (2) the sum content of siliceous minerals and carbonaceous minerals was moderately positively correlated with the brittleness index (BRIT) in well SS1H2-7 and in the well group of RS8 and RS5, indicating that the siliceous minerals and carbonaceous minerals had an active effect on reservoir compressibility. Finally, according to the mineralogical features of each sublayer, we identified four types of reservoirs to determine their scope for exploration.
- Published
- 2021
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32. Metabolic regulations of a decoction of Hedyotis diffusa in acute liver injury of mouse models
- Author
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Min Dai, Fenglin Wang, Zengcheng Zou, Gemin Xiao, Hongjie Chen, and Hongzhi Yang
- Subjects
Hedyotis diffusa ,Metabolomics ,Carbohydrate metabolism ,Hepatitis ,Mouse ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Background Dysfunctional metabolisms are contributed to LPS/GALN-induced hepatitis. However, whether Hedyotis diffusa (HD) employs metabolic strategies against hepatitis is unknown. Methods We use the cytokines expression, levels of serum alanine transaminase and aspartate transaminase, survival and histological analysis to measure the effect of decoction of HD on acute severe hepatitis of mouse induced by LPS/GALN. Meanwhile, we utilize GC/MS-based metabolomics to characterize the variation of metabolomes. Results The present study shows the relieving liver damage in HD decoction-treated mice. Metabolic category using differential metabolites indicates the lower percentage of carbohydrates in LPS/GALN + HD group than LPS/GALN group, revealing the value of carbohydrate metabolism in HD decoction-administrated mouse liver. Further pathway enrichment analysis proposes that citrate cycle, galactose metabolism, and starch and sucrose metabolism are three important carbohydrate metabolisms that involve in the protective effect of decoction of HD during acute hepatitis. Furthermore, other important enrichment pathways are biosynthesis of unsaturated fatty acids, alanine, aspartate and glutamate metabolism, and arginine and proline metabolism. Fatty acids or amino acids involved in above-mentioned pathways are also detected in high loading distribution on IC01 and IC02, thereby manifesting the significance of these metabolites. Other key metabolites detect in ICA analysis were cholesterol, lactic acid and tryptophan. Conclusions The variation tendency of above-mentioned metabolites is totally consistent with the protective nature of decoction of HD. These findings give a viewpoint that HD decoction-effected metabolic strategies are linked to underlying mechanisms of decoction of HD and highlight the importance of metabolic mechanisms against hepatitis.
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- 2017
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33. Learner Interaction with, and Response to, AI-Programmed Automated Writing Evaluation Feedback in EFL Writing: An Exploratory Study
- Author
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Hongzhi Yang, Chuan Gao, and Hui-zhong Shen
- Abstract
Recently, artificial intelligence (AI)-programmed automated writing evaluation (AWE) has attracted increasing attention in language research. Using a small data set arising from an analysis of five Chinese university-level English as a foreign language (EFL) students' submissions, this paper examined in detail how EFL students interacted with the feedback of Pigai, the largest AI-programmed AWE in China. The analysis started with the intention of capturing the machine feedback on the five students' submissions and the exchanges between the participants and Pigai over repeated submissions, ranging from 3 to 12 submissions. The analysis showed that the learners' interactions with Pigai focused on error corrective feedback in the initial two submissions. In the case of one student who had 12 submissions, the non-error corrective feedback increased gradually over time, providing rich linguistic resources but without examples and contextual information. The students' take-up rates of feedback with linguistic resources were much lower than that of error corrective and general feedback. A terrain model to map the stages and nature of student responses showed a more complete dynamic process, in which students' responses changed from the initial mechanical responses at the discrete language level to more considered approaches in response to machine feedback. The findings of this study have implications for both language pedagogy and the future design and development of AWE for second or foreign language learning.
- Published
- 2024
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34. Characteristics of Mineralogy, Lithofacies of Fine-Grained Sediments and Their Relationship with Sedimentary Environment: Example from the Upper Permian Longtan Formation in the Sichuan Basin
- Author
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Hongzhi Yang, Liangbiao Lin, Liqing Chen, Yu Yu, Du Li, Jingchun Tian, Wen Zhou, and Jianhua He
- Subjects
TOC ,shale lithofacies assemblages ,deposition environment ,the Late Permian ,Sichuan Basin ,Technology - Abstract
The Longtan Formation of the Upper Permian in the Sichuan Basin has become a significant target for shale gas exploration in recent years. Multiple methods, including outcrop observations, thin sections, total organic matter content, X-ray diffraction and scanning electron microscopy were used to investigate the mineralogy, shale lithofacies assemblages and their relationships with the deposition environment. The mineral composition of the Longtan Formation has strong mineral heterogeneity. The TOC values of the Longtan Formation have a wide distribution range from 0.07% to 74.67% with an average value of 5.73%. Four types of shale lithofacies assemblages of the Longtan Formation could be distinguished, as clayey mudstone (CLS), carbonaceous shale (CAS), siliceous shale (SS) and mixed shale (MS) on the basis of mineral compositions. The TOC values of various types of shale lithofacies assemblages in the Longtan Formation varied widely. The shore swamp of the Longtan Formation is most influenced by the terrestrial input and mainly develops CLS and MS. The tidal flat is influenced by the terrestrial input and can also deposit carbonate minerals, developing CLS, CAS and MS. The shallow water melanged accumulation shelf develops CAS and MS, dominated by clay and carbonate minerals. The deep water miscible shelf develops CLS and SS, whose mineral composition is similar to that of the shore swamp, but the quartz minerals are mainly formed by chemical and biological reactions, which are related to the Permian global chert event. The depositional environment of the Longtan Formation controls the shale mineral assemblage of the Longtan Formation and also influences the TOC content.
- Published
- 2021
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35. RF Up-Conversion and Waveform Generation Using a Frequency-Shifting Amplifying Fiber Loop, Application to Doppler Velocimetry
- Author
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Hongzhi Yang, Marc Brunel, Haiyang Zhang, Marc Vallet, Changming Zhao, and Suhui Yang
- Subjects
Radio frequency photonics ,fiber optics links and subsystems. ,Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
We investigate the radio-frequency (RF) up-conversion and waveform generation properties of an optical fiber loop including a frequency shifter and an amplifier. By seeding the loop with a single-frequency continuous-wave laser, one can develop a wide optically carried RF comb, whose spectral extension is governed by the loop net gain. In addition, by choosing the fiber loop length and the RF shifting frequency, arbitrary waveforms can be generated. We present an analytical interference model that includes the time delay, the frequency shift, and the gain. Experiments are conducted with 1.06-μm fiber-optic components. Using a 200-MHz acousto-optic frequency shifter, we find a 19-fold up-conversion up to 3.8 GHz with a typical in-loop gain of 3. Various waveforms including bright and dark pulses, square- or triangle shaped are achieved by properly adjusting the loop length and the frequency shift. A good agreement between experimental and theoretical results is obtained. The fully fibered microwave-photonic source is applied to a laboratory Doppler velocimetry demonstration. The gain in sensitivity obtained with the up-converted signal is readily observed.
- Published
- 2017
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36. Optimization of the key geological target parameters of shale-gas horizontal wells in the Changning Block, Sichuan Basin
- Author
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Hongzhi Yang, Xiaotao Zhang, Man Chen, Jianfa Wu, Jian Zhang, and Chuanqiang You
- Subjects
Sichuan Basin ,Changning Block ,Late Cambrian–Early Silurian ,Shale gas ,Horizontal well ,Productivity evaluation ,Prediction model ,Technical parameter ,Development design ,Gas industry ,TP751-762 - Abstract
In recent years, great progress has been made in geologic evaluation, engineering test and development optimization of the Lower Cambrian Wufeng Fm–Lower Silurian Longmaxi Fm shale gas in the Sichuan Basin, and the main shale gas exploitation technologies have been understood preliminarily. In addition, scale productivity construction has been completed in Jiaoshiba, Changning and Weiyuan blocks. In this paper, the Wufeng Fm–Longmaxi Fm shale gas wells in Changning Block were taken as the study object to provide technical reference for the development design of similar shale-gas horizontal wells. The technology combining geology with engineering, dynamic with static, and statistical analysis with simulation prediction was applied to quantify the main factors controlling shale-gas well productivity, develop the shale-gas well production prediction model, and optimize the key technical parameters of geologic target of shale-gas horizontal wells in the block (e.g. roadway orientation, location and spacing, horizontal section length and gas well production index). In order to realize high productivity of shale gas wells, it is necessary to maximize the included angle between the horizontal section orientation and the maximum major stress and fracture development direction, deploy horizontal-well roadway in top-quality shale layers, and drill the horizontal section in type I reservoirs over 1000 m long. It is concluded that high productivity of shale gas wells is guaranteed by the horizontal-well wellbore integrity and the optimized low-viscosity slickwater and ceramsite fracturing technology for complex fracture creation. Based on the research results, the technical policies for shale gas development of Changning Block are prepared and a guidance and reference are provided for the shale gas development and productivity construction in the block and the development design of similar shale-gas horizontal wells.
- Published
- 2016
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37. An Algorithm Based on Text Position Correction and Encoder-Decoder Network for Text Recognition in the Scene Image of Visual Sensors
- Author
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Zhiwei Huang, Jinzhao Lin, Hongzhi Yang, Huiqian Wang, Tong Bai, Qinghui Liu, and Yu Pang
- Subjects
scene text recognition ,visual sensor ,text position correction ,encoder-decoder network ,Chemical technology ,TP1-1185 - Abstract
Text recognition in natural scene images has always been a hot topic in the field of document-image related visual sensors. The previous literature mostly solved the problem of horizontal text recognition, but the text in the natural scene is usually inclined and irregular, and there are many unsolved problems. For this reason, we propose a scene text recognition algorithm based on a text position correction (TPC) module and an encoder-decoder network (EDN) module. Firstly, the slanted text is modified into horizontal text through the TPC module, and then the content of horizontal text is accurately identified through the EDN module. Experiments on the standard data set show that the algorithm can recognize many kinds of irregular text and get better results. Ablation studies show that the proposed two network modules can enhance the accuracy of irregular scene text recognition.
- Published
- 2020
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38. Learner interaction with, and response to, AI-programmed automated writing evaluation feedback in EFL writing: An exploratory study.
- Author
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Hongzhi Yang, Chuan Gao, and Hui-zhong Shen
- Published
- 2024
- Full Text
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39. A Study of the Insulation Mechanism and Anti-Frost Heave Effects of Polystyrene Boards in Seasonal Frozen Soil
- Author
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Fuqiang Guo, Haibin Shi, Manjin Cheng, Wenhui Gao, Hongzhi Yang, and Qingfeng Miao
- Subjects
polystyrene ,thermal conductivity ,insulation mechanism ,channel frost heave ,Hydraulic engineering ,TC1-978 ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
The damages resulting from frost heaving are the main causes of channel destruction in seasonal frozen soil regions. Over the years, many experimental studies have been performed regarding the channel anti-frost heaving in the Hetao irrigation area. However, there have been few experimental research studies conducted regarding the insulation and anti-frost heave effects of polystyrene boards (EPS) of different thicknesses. Therefore, in order to explore the insulation mechanism and anti-frost heave effects of precast EPS laid under the conditions of different thicknesses, an anti-frost heave test field was established in the Hetao irrigation area for the examination of the ground temperatures, frozen depths, frost heave amounts, and water content change rules. This study’s results showed that, for the laid EPS with thicknesses between 2 and 12 cm, the frost-heave reduction rate ranged from 53.2% to 92.6%; total accumulated temperature warming ranged from 248.65% to 565.93%; and the frozen depth reduction rate was between 59.8% and 75.9%. It was determined that the EPS per cm additions could effectively improve the ground temperatures at a buried depth of 30 cm by 0.78 °C, and reduce the frozen depth by 10.1 cm. Then, by comprehensively considering the positive economic and insulation effects, it was determined that the most appropriate thickness of the EPS laid under the precast concrete slabs in the Hetao irrigation area of Inner Mongolia was 8–10 cm.
- Published
- 2018
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40. Measurement of infrared optical constants with visible photons
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Anna Paterova, Hongzhi Yang, Chengwu An, Dmitry Kalashnikov, and Leonid Krivitsky
- Subjects
IR spectroscopy ,interferometry ,quantum and nonlinear optics ,Science ,Physics ,QC1-999 - Abstract
We demonstrate a new scheme for infrared spectroscopy with visible light sources and detectors. The technique relies on the nonlinear interference of correlated photons, produced via spontaneous parametric down conversion in a nonlinear crystal. Visible and infrared photons are split into two paths and the infrared photons interact with the sample under study. The photons are reflected back to the crystal, resembling a conventional Michelson interferometer. Interference of the visible photons is observed and it is dependent on the phases of all three interacting photons: pump, visible and infrared. The transmission coefficient and the refractive index of the sample in the infrared range can be inferred from the interference pattern of visible photons. The method does not require the use of potentially expensive and inefficient infrared detectors and sources, it can be applied to a broad variety of samples, and it does not require a priori knowledge of sample properties in the visible range.
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- 2018
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41. A Ratiometric Fluorescent Sensor for Cd2+ Based on Internal Charge Transfer
- Author
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Dandan Cheng, Xingliang Liu, Yadian Xie, Haitang Lv, Zhaoqian Wang, Hongzhi Yang, Aixia Han, Xiaomei Yang, and Ling Zang
- Subjects
ratiometric fluorescent sensor ,Me4BOPHY ,Cd2+ ion ,ICT ,Chemical technology ,TP1-1185 - Abstract
This work reports on a novel fluorescent sensor 1 for Cd2+ ion based on the fluorophore of tetramethyl substituted bis(difluoroboron)-1,2-bis[(1H-pyrrol-2-yl)methylene]hydrazine (Me4BOPHY), which is modified with an electron donor moiety of N,N-bis(pyridin-2-ylmethyl)benzenamine. Sensor 1 has absorption and emission in visible region, at 550 nm and 675 nm, respectively. The long wavelength spectral response makes it easier to fabricate the fluorescence detector. The sensor mechanism is based on the tunable internal charge transfer (ICT) transition of molecule 1. Binding of Cd2+ ion quenches the ICT transition, but turns on the π − π transition of the fluorophore, thus enabling ratiometric fluorescence sensing. The limit of detection (LOD) was projected down to 0.77 ppb, which is far below the safety value (3 ppb) set for drinking water by World Health Organization. The sensor also demonstrates a high selectivity towards Cd2+ in comparison to other interferent metal ions.
- Published
- 2017
- Full Text
- View/download PDF
42. Zebrafish on a chip: a novel platform for real-time monitoring of drug-induced developmental toxicity.
- Author
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Yinbao Li, Fan Yang, Zuanguang Chen, Lijuan Shi, Beibei Zhang, Jianbin Pan, Xinchun Li, Duanping Sun, and Hongzhi Yang
- Subjects
Medicine ,Science - Abstract
Pharmaceutical safety testing requires a cheap, fast and highly efficient platform for real-time evaluation of drug toxicity and secondary effects. In this study, we have developed a microfluidic system for phenotype-based evaluation of toxic and teratogenic effects of drugs using zebrafish (Danio rerio) embryos and larvae as the model organism. The microfluidic chip is composed of two independent functional units, enabling the assessment of zebrafish embryos and larvae. Each unit consists of a fluidic concentration gradient generator and a row of seven culture chambers to accommodate zebrafish. To test the accuracy of this new chip platform, we examined the toxicity and teratogenicity of an anti-asthmatic agent-aminophylline (Apl) on 210 embryos and 210 larvae (10 individuals per chamber). The effect of Apl on zebrafish embryonic development was quantitatively assessed by recording a series of physiological indicators such as heart rate, survival rate, body length and hatch rate. Most importantly, a new index called clonic convulsion rate, combined with mortality was used to evaluate the toxicities of Apl on zebrafish larvae. We found that Apl can induce deformity and cardiovascular toxicity in both zebrafish embryos and larvae. This microdevice is a multiplexed testing apparatus that allows for the examination of indexes beyond toxicity and teratogenicity at the sub-organ and cellular levels and provides a potentially cost-effective and rapid pharmaceutical safety assessment tool.
- Published
- 2014
- Full Text
- View/download PDF
43. A Cu2+-Selective Probe Based on Phenanthro-Imidazole Derivative
- Author
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Dandan Cheng, Xingliang Liu, Hongzhi Yang, Tian Zhang, Aixia Han, and Ling Zang
- Subjects
copper ion ,fluorescent probe ,phenanthro-imidazole ,Chemical technology ,TP1-1185 - Abstract
A novel fluorescent Probe 1, based on phenanthro-imidazole has been developed as an efficient chemosensor for the trace detection of copper ions (Cu2+). Probe 1 demonstrated sensitive fluorescence quenching upon binding with Cu2+ through 1:1 stoichiometric chelation. The detection limit for Cu2+ ions was projected through linear quenching fitting to be as low as 2.77 × 10−8 M (or 1.77 ppb). The sensing response was highly selective towards Cu2+ with minimal influence from other common metal ions, facilitating the practical application of Probe 1 in trace detection.
- Published
- 2016
- Full Text
- View/download PDF
44. Traceability Analysis of Cold Chain Food under COVID-19 Based on Block Chain Technology.
- Author
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Hongzhi Yang, Na Li, Yadong Huang, Songbo Mou, Fan Wu 0007, and Xin Li
- Published
- 2021
- Full Text
- View/download PDF
45. Design of Blockchain Smart Contract Based on Ring Signature.
- Author
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Hongzhi Yang, Linyun Yuan, and Shu Wang
- Published
- 2021
- Full Text
- View/download PDF
46. Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate immune signaling and pyroptosis
- Author
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Luyao, Xu, primary, Wenhai, Guo, additional, Jiaying, Dai, additional, Ya, Cheng, additional, Yun, Chen, additional, Wei, Liu, additional, Jiean, Xu, additional, Wen, Su, additional, Xiaodong, Zhang, additional, Changjun, Wang, additional, Hongzhi, Yang, additional, Jinwen, Xu, additional, and Yaxing, Zhang, additional
- Published
- 2024
- Full Text
- View/download PDF
47. A CFAR Target-Detection Method Based on Superpixel Statistical Modeling.
- Author
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Zongyong Cui, Zesheng Hou, Hongzhi Yang, Nengyuan Liu, and Zongjie Cao
- Published
- 2021
- Full Text
- View/download PDF
48. Discovering High Demanding Bus Routes Using Farecard Data.
- Author
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Hongzhi Yang, Chieh-Feng Chiang, and Arbee L. P. Chen
- Published
- 2019
- Full Text
- View/download PDF
49. A sociocultural framework for exploring pre-service teacher dispositions: the role of experience and situation (Un enfoque sociocultural para el estudio de las tendencias de los profesores en prácticas: el papel de la experiencia y la situación)
- Author
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Hongzhi Yang and Lina Markauskaite
- Subjects
Cultural Studies ,Education - Published
- 2023
50. Susceptibility zoning of karst geological hazards using machine learning and cloud model
- Author
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Xingli, Jia, Qingmiao, Dai, and Hongzhi, Yang
- Published
- 2019
- Full Text
- View/download PDF
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