Mechanism of Curcumin and/or Aerobic Exercise Improving Pyroptosis in Myocardium of Hyperlipidemic Rats

To study the mechanism of curcumin and/or aerobic exercise improving pyroptosis in myocardium of hyperlipidemic rats. Fifty 5-week-old male SD rats were randomly divided into normal diet control group (RDC), high fat diet control group (HDC), high fat diet with curcumin group (HDCC), high fat diet with aerobic exercise group (HDM), high fat diet with curcumin and aerobic exercise group (HDCM), ten in each group. From the third week, group HDCC and HDCM were injected intragastrically with curcumin at 400 g/(kg·d), and the other groups were given an equal volume of 0.5% sodium carboxymethylcellulose. Group HDM and HDCM performed aerobic exercise intervention, and the other groups did not. Twenty-four hours after the end of 6-week-intervention, the myocardial microstructure in each group was observed, blood and myocardium related biochemical indicators were tested. The results showed that, serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), HDC were significantly higher than RDC (P