153 results on '"Hideaki Imai"'
Search Results
2. Differences in Clinical Features among Different Onset Patterns in Moyamoya Disease
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Yudai Hirano, Satoru Miyawaki, Hideaki Imai, Hiroki Hongo, Yu Teranishi, Shogo Dofuku, Daiichiro Ishigami, Kenta Ohara, Satoshi Koizumi, Hideaki Ono, Hirofumi Nakatomi, and Nobuhito Saito
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asymptomatic moyamoya disease ,cerebrovascular events ,hemorrhagic onset ,ischemic onset ,moyamoya disease ,natural history ,Medicine - Abstract
Moyamoya disease is characterized by severe stenosis at the ends of the bilateral internal carotid arteries and the development of collateral circulation. The disease is very diverse in terms of age at onset, onset patterns, radiological findings, and genetic phenotypes. The pattern of onset is mainly divided into ischemic and hemorrhagic onsets. Recently, the opportunity to identify asymptomatic moyamoya disease, which sometimes manifests as nonspecific symptoms such as headache and dizziness, through screening with magnetic resonance imaging has been increasing. Various recent reports have investigated the associations between the clinical features of different onset patterns of moyamoya disease and the corresponding imaging characteristics. In this article, we have reviewed the natural history, clinical features, and imaging features of each onset pattern of moyamoya disease.
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- 2021
- Full Text
- View/download PDF
3. Treating Pulsatile Exophthalmos in Child with Minimally Invasive Approach and Custom-made Titanium Mesh Plate
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Yuta Moriwaki, MD, Yoko Tomioka, PhD, Hideaki Imai, PhD, Takuya Iida, PhD, Shuji Yamashita, PhD, Koji Kanayama, PhD, Naoaki Iwamoto, MD, and Mutsumi Okazaki, PhD
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Surgery ,RD1-811 - Abstract
Summary:. Orbital roof fracture is a relatively rare trauma. In most cases, surgical intervention is not needed since the fracture is slight. However, invasive surgical procedures are inevitable once pulsatile exophthalmos occurs if vision impairment is to be avoided. We report our rare experience of orbital roof fracture in a child with pulsatile exophthalmos. Good reconstruction of the anterior cranial base was achieved using a custom-made titanium mesh and a minimally invasive approach. A 3-year-old girl who had been diagnosed with subdural hematoma, brain contusion, and fracture of the right orbital roof caused by facial bruising underwent emergent external decompression by coronal skin incision and a transcranial approach on the same day as the trauma. Cranioplasty using autologous frozen bone in the same approach was performed 103 days posttrauma, but this was followed by pulsatile exophthalmos. After recovering from critical stage, the girl was brought to our department for reconstruction of the anterior base. Risk of vision impairment was also one reason for reconstruction, but the neurosurgeon hesitated to approach the region using a coronal approach considering the possibility of infection in the frozen autologous bone. Through cross-team discussion, reconstruction using a subeyebrow incision was performed with a custom-made titanium mesh plate. Pulsatile exophthalmos completely disappeared. Pulsatile exophthalmos is a very rare but serious complication that carries a risk of vision impairment. By applying a custom-made titanium mesh plate, precise reconstruction was enabled with minimal invasiveness and low risk.
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- 2019
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4. Registration Method Between Phase-Contrast Magnetic Resonance Angiography and Time-of-Flight Magnetic Resonance Angiography - A Preliminary Study.
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Seiji Nomura, Taichi Kin, Akira Kunimatsu, Masaaki Shojima, Yasushi Watanebe, Yuuichi Suzuki, Naoyuki Shono, Hideaki Imai, Toki Saito, Hirofumi Nakatomi, Hiroshi Oyama 0001, and Nobuhito Saito
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- 2021
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5. Mesenchymal Stromal Cell Implants for Chronic Motor Deficits After Traumatic Brain Injury: Post Hoc Analysis of a Randomized Trial.
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Okonkwo, David O., McAllister, Peter, Achrol, Achal S., Yasuaki Karasawa, Masahito Kawabori, Cramer, Steven C., Lai, Albert, Santosh Kesari, Frishberg, Benjamin M., Groysman, Leonid I., Kim, Anthony S., Schwartz, Neil E., Chen, Jefferson W., Hideaki Imai, Takao Yasuhara, Dai Chida, Nejadnik, Bijan, Bates, Damien, Stonehouse, Anthony H., and Richardson, R. Mark
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- 2024
- Full Text
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6. Five-Year Stroke Risk and Its Predictors in Asymptomatic Moyamoya Disease: Asymptomatic Moyamoya Registry (AMORE)
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Satoshi Kuroda, Shusuke Yamamoto, Takeshi Funaki, Miki Fujimura, Hiroharu Kataoka, Tomohito Hishikawa, Jun Takahashi, Hidenori Endo, Tadashi Nariai, Toshiaki Osato, Nobuhito Saito, Norihiro Sato, Emiko Hori, Yoichi M. Ito, Susumu Miyamoto, Motoki Inaji, Kenichi Morita, Daisuke Maruyama, Jyoji Nakagawara, Naoki Hashimura, Eika Hamano, Koji Iihara, Nobuo Hashimoto, Kaori Honjo, Hirohiko Nakamura, Daina Kashiwazaki, Hideaki Imai, Satoru Miyawaki, Hiroki Hongo, Kazumichi Yoshida, Takayuki Kikuchi, Yohei Mineharu, Makoto Isozaki, Kenichiro Kikuta, Yoshio Araki, Fumiaki Kanamori, Isao Date, Junichi Ono, Toshio Machida, Mitsuhito Mase, Hiroyuki Katano, Koji Yamaguchi, Takakazu Kawamata, Teiji Tominaga, Haruto Uchino, Kikutaro Tokairin, Masaki Ito, Kiyohiro Houkin, Kohei Chida, Kuniaki Ogasawara, Izumi Nagata, Nobutaka Horie, Hidehiro Oka, Toshihiro Kumabe, Yoshiaki Itoh, Takato Abe, Koichi Oki, Shinichi Takahashi, and Norihiro Suzuki
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Advanced and Specialized Nursing ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine - Abstract
Background: Long-term outcomes are unknown in patients with asymptomatic moyamoya disease. In this report, we aimed to clarify their 5-year risk of stroke and its predictors. Methods: We are conducting a multicenter, prospective cohort study (Asymptomatic Moyamoya Registry) in Japan. Participants were eligible if they were 20 to 70 years, had bilateral or unilateral moyamoya disease, experienced no episodes suggestive of TIA and stroke; and were functionally independent (modified Rankin Scale score 0–1). Demographic and radiological information was collected at enrollment. In this study, they are still followed up for 10 years. In this interim analysis, we defined the primary end point as a stroke occurring during a 5-year follow-up period. Independent predictors for stroke were also determined, using a stratification analysis method. Results: Between 2012 and 2015, we enrolled 109 patients, of whom 103 patients with 182 involved hemispheres completed the 5-year follow-up. According to the findings on DSA and MRA, 143 hemispheres were judged as moyamoya disease and 39 hemispheres as questionable manifestations (isolated middle cerebral artery stenosis). The patients with questionable hemispheres were significantly older, more often male, and more frequently had hypertension than those with moyamoya hemisphere. Moyamoya hemispheres developed 7 strokes, including 6 hemorrhagic and 1 ischemic stroke, during the first 5 years. The annual risk of stroke was 1.4% per person, 0.8% per hemisphere, and 1.0% per moyamoya hemisphere. Independent predictor for stroke was Grade-2 choroidal anastomosis (hazard ratio, 5.05 [95% CI, 1.24–20.6]; P =0.023). Furthermore, microbleeds (hazard ratio, 4.89 [95% CI, 1.13-21.3]; P =0.0342) and Grade-2 choroidal anastomosis (hazard ratio, 7.05 [95% CI, 1.62–30.7]; P =0.0093) significantly predicted hemorrhagic stroke. No questionable hemispheres developed any stroke. Conclusions: The hemispheres with asymptomatic moyamoya disease may carry a 1.0% annual risk of stroke during the first 5 years, the majority of which are hemorrhagic stroke. Grade-2 choroidal anastomosis may predict stroke, and the microbleeds and Grade-2 choroidal anastomosis may carry the risk for hemorrhagic stroke. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: UMIN000006640.
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- 2023
7. Clinical and Genetic Characteristics of Patients with Moyamoya Disease who Experienced Both Ischemic and Hemorrhagic Events
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Yudai Hirano, Satoru Miyawaki, Hideaki Imai, Hiroki Hongo, Yu Teranishi, Daiichiro Ishigami, Yu Sakai, Daisuke Shimada, Motoyuki Umekawa, Masafumi Segawa, Satoshi Koizumi, Hideaki Ono, Hirofumi Nakatomi, and Nobuhito Saito
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Surgery ,Neurology (clinical) - Published
- 2023
8. Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study
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Shogo Dofuku, Kyuto Sonehara, Satoru Miyawaki, Saori Sakaue, Hideaki Imai, Masahiro Shimizu, Hiroki Hongo, Yuki Shinya, Kenta Ohara, Yu Teranishi, Atsushi Okano, Hideaki Ono, Hirofumi Nakatomi, Akira Teraoka, Kenichi Yamamoto, Yuichi Maeda, Takuro Nii, Toshihiro Kishikawa, Ken Suzuki, Jun Hirata, Meiko Takahashi, Koichi Matsuda, Atsushi Kumanogoh, Fumihiko Matsuda, Yukinori Okada, and Nobuhito Saito
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General Neuroscience ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine - Published
- 2022
9. Multiple Spinal Syphilitic Gummas Diagnosed by Postoperative Histopathology and Antibiotic Responsiveness: A Case Report
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Manabu Niimura and Hideaki Imai
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Surgical resection ,medicine.medical_specialty ,medicine.drug_class ,business.industry ,spinal syphilitic gumma ,Antibiotics ,Case Report ,surgical resection ,medicine.disease ,Surgery ,Neurosyphilis ,differential diagnosis ,antibiotic treatment ,medicine ,neurosyphilis ,Histopathology ,Differential diagnosis ,business - Abstract
Neurosyphilis is an infection of the central nervous system by Treponema pallidum. Gummatous neurosyphilis, especially spinal syphilitic gumma, is an exceedingly rare manifestation and may be misdiagnosed as other tumors due to its rarity. A 42-year-old man with a medical history of treatment for syphilis presented with rapidly progressive leg paralysis, leg sensory disturbance, and bladder and rectal disturbance. Spinal MRI demonstrated an intradural extramedullary lesion strongly compressing the spinal cord at the T6/7 level, which was accompanied with dural tail sign and perilesional meningeal thickening at the T6–T8 levels. Small intradural extramedullary lesions were also detected at the T1 and T8 levels. Serological and cerebrospinal fluid examinations for syphilis were both positive. In the treatment of spinal syphilitic gumma, the decompression of the spinal cord by lesionectomy followed by postoperative antibiotic treatment is considered to be an optimal procedure in patients with rapid progression of neurological deterioration. In the present case, the symptomatic main lesion that was compressing the thoracic cord was excised by surgery and analyzed by histopathological examination, and another small asymptomatic lesion was resolved by postoperative antibiotic treatment. Spinal syphilitic gumma was diagnosed using both histopathological findings of the surgically resected lesion and another residual lesion that was resolved by postoperative antibiotic treatment.
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- 2021
10. Research on the Characteristic Evaluation of Electromagnetic Shielding Material for Aircraft Windows
- Author
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Masahiko Hinatase, Naruto Yonemoto, Hideaki Imai, Kazuyuki Oguri, and Tomohiro Isshiki
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Materials science ,Acoustics ,Electromagnetic shielding - Published
- 2021
11. Registration Method Between Phase-Contrast Magnetic Resonance Angiography and Time-of-Flight Magnetic Resonance Angiography—A Preliminary Study
- Author
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Nobuhito Saito, Naoyuki Shono, Hiroshi Oyama, Toki Saito, Yasushi Watanebe, Yuuichi Suzuki, Akira Kunimatsu, Hirofumi Nakatomi, Seiji Nomura, Taichi Kin, Masaaki Shojima, and Hideaki Imai
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Time of flight ,Nuclear magnetic resonance ,Materials science ,medicine.diagnostic_test ,law ,Phase contrast microscopy ,medicine ,Health Informatics ,Radiology, Nuclear Medicine and imaging ,equipment and supplies ,human activities ,Magnetic resonance angiography ,law.invention - Abstract
Purpose: To evaluate a new method that registers phase-contrast magnetic resonance angiography images to time-of-flight magnetic resonance angiography images. Methods: Magnetic resonance angiography datasets of 10 healthy volunteers obtained by using two modalities (phase-contrast magnetic resonance angiography and time-of-flight magnetic resonance angiography) were preprocessed. Specifically, vessel regions were extracted using the region growing method with a threshold of 10% of the signal intensity maximum or 50% of the signal intensity maximum for phase-contrast magnetic resonance angiography images and time-of-flight magnetic resonance angiography images, respectively. Then, the normalized mutual information method was used to determine spatial positions, and registration between non-preprocessed phase-contrast magnetic resonance angiography and time-of-flight magnetic resonance angiography was performed using the spatial position information. Misalignment of 3 anatomical points was used to compare the accuracy of registration in this data group (the proposed method group) to that in the data group without registration (the non-registration group) and that in the data group subjected to normalized mutual information-based registration without preprocessing (the non-preprocessing group). Results: The mean misalignment of 3 anatomical points ± standard error was 1.69 ± 0.11 mm in the proposed method group, and 2.77± 0.13 mm and 90.28 ± 8.24 mm in the non-registration group and non-preprocessing group, respectively. The mean misalignment of 3 anatomical points was significantly smaller in the proposed method group than in the non-registration group (p = 0 001). Conclusions: The proposed preprocessing and registration method improved the accuracy of normalized mutual information-based registration between phase-contrast magnetic resonance angiography images and time-of-flight magnetic resonance angiography images.
- Published
- 2021
12. Current Status and Technological Trends Regarding the Efficiency of Maintenance and Maintenance Work at Hydropower Plants
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Hideki Sakai, Hideaki Imai, and Toshihiko Ota
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Engineering ,Work (electrical) ,business.industry ,Energy Engineering and Power Technology ,Electrical and Electronic Engineering ,Environmental economics ,Current (fluid) ,business ,Hydropower - Published
- 2020
13. Pharmacological Profile and Therapeutic Potential of Ulotaront, a Novel Candidate for the Treatment of Schizophrenia
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Hideaki, Imai, primary, Nina, Dedic, additional, Heather, Dworak, additional, Seth, Hopkins, additional, Courtney, Zeni, additional, and Kenneth, Koblan, additional
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- 2022
- Full Text
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14. EPEN-27. Epigenetic dissection of spinal ependymomas (SP-EPN) separates tumors with and withoutNF2 mutation
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Sina Neyazi, Erika Yamazawa, Catena Kresbach, Genta Nagae, Alicia Eckhardt, Takayoshi Umeda, Lara Pohl, Kenji Tatsuno, Ceren Saygi, Taijun Hana, Malik Alawi, Phyo Kim, Mario M Dorostkar, Fumi Higuchi, Abigail K Suwala, Toshihiro Takami, Annika Wefers, Yuta Nakanishi, Leonille Schweizer, Keisuke Takai, Lara Engertsberger, Takashi Komori, Theresa Mohme, Hirokazu Takami, Martin Mynarek, Masashi Nomura, Karin Lamszus, Akitake Mukasa, Lan Kluwe, Shunsaku Takayanagi, Andreas von Deimling, Kazuhiko Ishii, Martin Benesch, Hideaki Imai, Matija Snuderl, Stephan Frank, Koichi Ichimura, Christian Hagel, Viktor F Mautner, Stefan Rutkowski, Shota Tanaka, Hiroyuki Aburatani, Saito Nobuhito, and Ulrich Schüller
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Cancer Research ,Oncology ,Neurology (clinical) - Abstract
Ependymomas encompass multiple, clinically relevant tumor types based on localization, genetic alterations, and epigenetic and transcriptomic profiles. Tumors belonging to the methylation class of spinal ependymoma (SP-EPN) represent the most common intramedullary neoplasms in children and adults. However, molecular data of SP-EPN are scarce, and clear treatment recommendations are lacking. The only known recurrent genetic events in SP-EPN are loss of chromosome 22q and NF2 mutations. Yet, it remains unclear whether SP-EPN with germline or sporadic NF2 mutations or with NF2 wild type status differ clinically or molecularly. To provide a comprehensive molecular profile of SP-EPN, we integrated epigenetic, genomic, transcriptomic, and histological analyses of up to 237 cases. Clustering of methylation data revealed two distinct molecular SP-EPN subtypes. The distribution of NF2 mutated cases differed significantly across these subtypes (p
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- 2022
15. RNF213 p.Arg4810Lys Heterozygosity in Moyamoya Disease Indicates Early Onset and Bilateral Cerebrovascular Events
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Masafumi Segawa, Hideaki Ono, Yudai Hirano, Yu Teranishi, Hiroki Hongo, Nobuhito Saito, Hirofumi Nakatomi, Satoshi Koizumi, Satoru Miyawaki, Daiichiro Ishigami, Hideaki Imai, Daisuke Shimada, Masahiro Shimizu, Shogo Dofuku, and Kenta Ohara
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Adenosine Triphosphatases ,medicine.medical_specialty ,business.industry ,General Neuroscience ,Ubiquitin-Protein Ligases ,Retrospective cohort study ,medicine.disease ,Logistic regression ,Asymptomatic ,Loss of heterozygosity ,Internal medicine ,medicine ,Humans ,Medical history ,Genetic Predisposition to Disease ,Neurology (clinical) ,Moyamoya disease ,medicine.symptom ,Family history ,Moyamoya Disease ,Cardiology and Cardiovascular Medicine ,business ,Stroke ,Retrospective Studies - Abstract
The relationship between RNF213 c.14429G > A (p.Arg4810Lys) heterozygous variants and clinical manifestation in patients with Moyamoya disease (MMD) remains unclear. We performed a retrospective cohort analysis to clarify the genotype-phenotype correlation of this RNF213 hotspot variant in MMD patients, especially between wild-type (GG) and heterozygous (GA) genotypes. Clinical and genetic data were obtained from patients diagnosed with MMD in our institutions between October 2011 and November 2020. Clinical data included age, sex, neurological status at diagnosis, medical history, smoking history, alcohol intake, and family history. Of the 225 enrolled patients, 160 (71.1%) were symptomatic, 3 (1.3%) had the homozygous variant, and 149 (66.2%) had the heterozygous variant (GA). Analysis of all enrolled patients showed that the GA group was prone to present bilateral symptoms (p = 0.008) and progressive status (Suzuki grade ≥ 4; p = 0.017). Analysis limited to symptomatic patients revealed that the GA group had bilateral symptoms (p = 0.017), younger age at onset (p = 0.043), and, in particular, a higher proportion of onset before 25 years of age (p = 0.021). Multivariate logistic regression analysis of overall patients revealed that earlier age at diagnosis (p
- Published
- 2021
16. Differences in Clinical Features among Different Onset Patterns in Moyamoya Disease
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Kenta Ohara, Hirofumi Nakatomi, Yudai Hirano, Shogo Dofuku, Satoru Miyawaki, Satoshi Koizumi, Hideaki Imai, Daiichiro Ishigami, Hideaki Ono, Hiroki Hongo, Nobuhito Saito, and Yu Teranishi
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medicine.medical_specialty ,Carotid arteries ,Disease ,Review ,Asymptomatic ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,risk factors ,cerebrovascular events ,Severe stenosis ,Moyamoya disease ,hemorrhagic onset ,asymptomatic moyamoya disease ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Collateral circulation ,Natural history ,onset pattern ,ischemic onset ,natural history ,Cardiology ,Medicine ,medicine.symptom ,business ,moyamoya disease ,030217 neurology & neurosurgery - Abstract
Moyamoya disease is characterized by severe stenosis at the ends of the bilateral internal carotid arteries and the development of collateral circulation. The disease is very diverse in terms of age at onset, onset patterns, radiological findings, and genetic phenotypes. The pattern of onset is mainly divided into ischemic and hemorrhagic onsets. Recently, the opportunity to identify asymptomatic moyamoya disease, which sometimes manifests as nonspecific symptoms such as headache and dizziness, through screening with magnetic resonance imaging has been increasing. Various recent reports have investigated the associations between the clinical features of different onset patterns of moyamoya disease and the corresponding imaging characteristics. In this article, we have reviewed the natural history, clinical features, and imaging features of each onset pattern of moyamoya disease.
- Published
- 2021
17. Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study
- Author
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Shogo, Dofuku, Kyuto, Sonehara, Satoru, Miyawaki, Saori, Sakaue, Hideaki, Imai, Masahiro, Shimizu, Hiroki, Hongo, Yuki, Shinya, Kenta, Ohara, Yu, Teranishi, Atsushi, Okano, Hideaki, Ono, Hirofumi, Nakatomi, Akira, Teraoka, Kenichi, Yamamoto, Yuichi, Maeda, Takuro, Nii, Toshihiro, Kishikawa, Ken, Suzuki, Jun, Hirata, Meiko, Takahashi, Koichi, Matsuda, Atsushi, Kumanogoh, Fumihiko, Matsuda, Yukinori, Okada, and Nobuhito, Saito
- Abstract
The genetic background of intracranial artery stenosis (ICAS), a major cause of ischemic stroke, remains elusive. We performed the world's first genome-wide association study (GWAS) of ICAS using DNA samples from Japanese subjects, to identify the genetic factors associated with ICAS and their correlation with clinical features. We also conducted a phenome-wide association study (PheWAS) of the top variant identified via GWAS to determine its association with systemic disease. The GWAS involved 408 patients with ICAS and 349 healthy controls and utilized an Asian Screening Array of venous blood samples. The PheWAS was performed using genotypic and phenotypic data of the Biobank Japan Project, which contained information on 46 diseases and 60 quantitative trait data from 150,000 Japanese individuals. The GWAS revealed that the East Asian-specific functional variant of RNF213, rs112735431 (c.14429G A, p.Arg4810Lys), was associated with ICAS (odds ratio, 12.3; 95% CI 5.5 to 27.5; P = 7.8 × 10
- Published
- 2021
18. Stem cell implants show promise in chronic traumatic brain injury
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Laroslav Zinkevych, Dai Chida, Alan Weintraub, Yasuaki Karasawa, Bijan Nejadnik, Daniel C. Lu, Hajime Nakamura, David O. Okonkwo, Masahito Kawabori, Takehiko Kaneko, Neil E. Schwartz, Susan Paadre, Jefferson W. Chen, Achal S. Achrol, Benjamin M. Frishberg, Steven C. Cramer, Takao Yasuhara, Douglas Kondziolka, Jun Suenaga, Peter McAllister, Anthony H. Stonehouse, Gary K. Steinberg, Damien Bates, Ihor Semeniv, Hideaki Imai, and R. Mark Richardson
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0301 basic medicine ,Randomization ,Physical Injury - Accidents and Adverse Effects ,Traumatic brain injury ,Population ,Clinical Trials and Supportive Activities ,Clinical Sciences ,MEDLINE ,Traumatic Brain Injury (TBI) ,Bioinformatics ,Mean difference ,Article ,Cell therapy ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Injury - Trauma - (Head and Spine) ,Clinical Research ,Medicine ,In patient ,Adverse effect ,education ,Traumatic Head and Spine Injury ,education.field_of_study ,Neurology & Neurosurgery ,business.industry ,Neurosciences ,Interim analysis ,medicine.disease ,Brain Disorders ,030104 developmental biology ,Anesthesia ,Injury (total) Accidents/Adverse Effects ,Cognitive Sciences ,Neurology (clinical) ,Patient Safety ,Stem cell ,Injury - Traumatic brain injury ,business ,030217 neurology & neurosurgery - Abstract
ObjectiveTo determine whether chronic motor deficits secondary to traumatic brain injury (TBI) can be improved by implantation of allogeneic modified bone marrow–derived mesenchymal stromal/stem cells (SB623).MethodsThis 6-month interim analysis of the 1-year double-blind, randomized, surgical sham–controlled, phase 2 Stem Cell Therapy for Traumatic Brain Injury (STEMTRA) trial (NCT02416492) evaluated safety and efficacy of the stereotactic intracranial implantation of SB623 in patients with stable chronic motor deficits secondary to TBI. Patients in this multicenter trial (n = 63) underwent randomization in a 1:1:1:1 ratio to 2.5 × 106, 5.0 × 106, or 10 × 106 SB623 cells or control. Safety was assessed in patients who underwent surgery (n = 61), and efficacy was assessed in the modified intent-to-treat population of randomized patients who underwent surgery (n = 61; SB623 = 46, control = 15).ResultsThe primary efficacy endpoint of significant improvement from baseline of Fugl-Meyer Motor Scale score at 6 months for SB623-treated patients was achieved. SB623-treated patients improved by (least square [LS] mean) 8.3 (standard error 1.4) vs 2.3 (standard error 2.5) for control at 6 months, the LS mean difference was 6.0 (95% confidence interval 0.3–11.8, p = 0.040). Secondary efficacy endpoints improved from baseline but were not statistically significant vs control at 6 months. There were no dose-limiting toxicities or deaths, and 100% of SB623-treated patients experienced treatment-emergent adverse events vs 93.3% of control patients (p = 0.25).ConclusionsSB623 cell implantation appeared to be safe and well tolerated, and patients implanted with SB623 experienced significant improvement from baseline motor status at 6 months compared to controls.ClinicalTrials.gov Identifier:NCT02416492.Classification of EvidenceThis study provides Class I evidence that implantation of SB623 was well tolerated and associated with improvement in motor status.
- Published
- 2021
19. Complementary electrochromic devices based on acrylic substrates for smart window applications in aircrafts
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Kazuki Tajima, Hideaki Imai, Takashi Kubota, Masakazu Kitamura, and Chan Yang Jeong
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Prussian blue ,Materials science ,business.industry ,Electrolyte ,Substrate (electronics) ,Condensed Matter Physics ,Electrochromic devices ,medicine.disease_cause ,Indium tin oxide ,chemistry.chemical_compound ,chemistry ,Electrochromism ,medicine ,Optoelectronics ,General Materials Science ,Thin film ,business ,Ultraviolet - Abstract
Electrochromic devices (ECDs) fabricated using resin substrates are attracting considerable interest owing to their advantages of shape deformability and low weight. Acrylic substrates are used to fabricate aircraft windows because they are lighter and more impact-resistant than glass substrates. In this study, the wettability of an indium tin oxide (ITO) surface was enhanced using ultraviolet (UV) treatment prior to the spin-coating and deposition of Prussian blue (PB) and WO3 thin films, which were prepared using functional nanoparticle-dispersed inks on an ITO/acrylic substrate. The fabricated ECD was structured as acrylic/ITO/PB/K+-base gel electrolyte/WO3/ITO/acrylic, and was observed to exhibit excellent electrochromic performance. A high optical modulation and coloration efficiency of 76% and 118.37 cm2/C at a wavelength of 633 nm, respectively, and satisfactory cyclic durability over 1800 cycles were observed. The fabricated ECD possesses immense potential for application in various fields, especially in the field of smart windows for aircrafts.
- Published
- 2022
20. Association Between the Onset Pattern of Adult Moyamoya Disease and Risk Factors for Stroke
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Yudai Hirano, Kenta Ohara, Satoru Miyawaki, Hirofumi Nakatomi, Yu Teranishi, Hiroki Hongo, Nobuhito Saito, Hideaki Imai, and Shogo Dofuku
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,0502 economics and business ,medicine ,Humans ,Moyamoya disease ,Stroke ,Retrospective Studies ,Advanced and Specialized Nursing ,medicine.diagnostic_test ,business.industry ,05 social sciences ,Brain ,Magnetic resonance imaging ,Cerebral Arteries ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Natural history ,050211 marketing ,Female ,Neurology (clinical) ,Moyamoya Disease ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery ,Magnetic Resonance Angiography - Abstract
Background and Purpose: Few previous studies have comprehensively explored the relationship between the onset pattern of adult moyamoya disease and risk factors for stroke. We performed a retrospective analysis focusing on risk factors for stroke and related findings on magnetic resonance imaging/angiography with respect to the pattern of disease onset. We also examined whether risk factors for stroke were associated with an increased risk for symptomization in asymptomatic patients. Methods: A total of 178 adult patients with moyamoya disease (asymptomatic, n=84; ischemic, n=71; hemorrhagic, n=23) at the University of Tokyo Hospital from 2000 to 2018 were included in this study. Data pertaining to patient background and magnetic resonance imaging findings were analyzed retrospectively. In the asymptomatic group, the effects of stroke-associated risk factors on symptom onset were analyzed. Results: Comparisons among the 3 groups revealed no significant difference in the frequency of risk factors for stroke. The proportion of patients with magnetic resonance imaging/angiography findings indicating anterior choroidal artery anastomosis or microbleeds was significantly higher in the hemorrhagic group than in the asymptomatic or ischemic group. Among asymptomatic patients, the hazard ratios for symptomization with hypertension and dyslipidemia were 6.69 ([95% CI, 1.23–36.4] P =0.028) and 8.14 ([95% CI, 1.46–45.2] P =0.017), respectively. Conclusions: The development of anterior choroidal artery anastomosis and microbleeds on magnetic resonance imaging/angiography was significantly associated with hemorrhagic onset. Hypertension and dyslipidemia may increase the risk of cerebrovascular events in asymptomatic patients, and thus, early intervention to these factors may be important.
- Published
- 2020
21. Comprehensive investigation of RNF213 nonsynonymous variants associated with intracranial artery stenosis
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Yu Teranishi, Hiroyuki Ishiura, Masahiro Shimizu, Shinichi Yagi, Wei Qu, Hideaki Imai, Jun Yoshimura, Tsuneo Shimizu, Shoji Tsuji, Jun Mitsui, Shinichi Morishita, Koichiro Doi, Hiroki Hongo, Nobuhito Saito, Atsushi Okano, Hirofumi Nakatomi, Satoru Miyawaki, and Hideaki Ono
- Subjects
Adult ,Male ,Nonsynonymous substitution ,medicine.medical_specialty ,dbSNP ,Adolescent ,Genotype ,Ubiquitin-Protein Ligases ,Mutation, Missense ,lcsh:Medicine ,Constriction, Pathologic ,030204 cardiovascular system & hematology ,Polymorphism, Single Nucleotide ,Gastroenterology ,Article ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Polymorphism (computer science) ,Internal medicine ,medicine ,Humans ,Missense mutation ,Genetic Predisposition to Disease ,Moyamoya disease ,lcsh:Science ,Alleles ,Genetic Association Studies ,Aged ,Adenosine Triphosphatases ,Aged, 80 and over ,Multidisciplinary ,Molecular medicine ,business.industry ,lcsh:R ,Genetic Variation ,Intracranial Artery ,Sequence Analysis, DNA ,Middle Aged ,medicine.disease ,Stenosis ,Amino Acid Substitution ,Risk factors ,Female ,lcsh:Q ,Intracranial Arterial Diseases ,business ,030217 neurology & neurosurgery - Abstract
Intracranial artery stenosis (ICAS) is the most common cause of ischemic stroke worldwide. RNF213 single nucleotide variant c.14429G > A (p.Arg4810Lys, rs112735431) was recently reported to be associated with ICAS in East Asians. However, the disease susceptibility of other RNF213 variants has not been clarified. This study comprehensively investigated ICAS-associated RNF213 variants in a pool of 168 Japanese ICAS patients and 1,194 control subjects. We found 138 nonsynonymous germline variants by target resequencing of all coding exons in RNF213. Association study between ICAS patients and control subjects revealed that only p.Arg4810Lys had significant association with ICAS (P = 1.5 × 10–28, odds ratio = 29.3, 95% confidence interval 15.31–56.2 [dominant model]). Fourteen of 138 variants were rare variants detected in ICAS patients not harboring p.Arg4810Lys variant. Two of these rare variants (p.Cys118Arg and p.Leu2356Phe) consistent with variants previously reported in moyamoya disease patients characterized by stenosis of intracranial artery and association with RNF213, and three rare variants (p.Ser193Gly, p.Val1817Leu, and p.Asp3329Tyr) were found neither in control subjects and Single Nucleotide Polymorphism Database. The present findings may improve our understanding of the genetic background of intracranial artery stenosis.
- Published
- 2020
22. Clinical Importance of RNF213 rs112735431 Revealed by Genome-Wide Association Study of Intracranial Artery Stenosis and Phenome-Wide Association Study
- Author
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Shogo Dofuku, Kyuto Sonehara, Satoru Miyawaki, Saori Sakaue, Hideaki Imai, Masahiro Shimizu, Hiroki Hongo, Yuki Shinya, Kenta Ohara, Yu Teranishi, Atsushi Okano, Hideaki Ono, Hirofumi Nakatomi, Akira Teraoka, Kenichi Yamamoto, Yuichi Maeda, Takuro Nii, Toshihiro Kishikawa, Ken Suzuki, Jun Hirata, Meiko Takahashi, Koichi Matsuda, Atsushi Kumanogoh, Fumihiko Matsuda, Yukinori Okada, and Nobuhito Saito
- Published
- 2020
23. Precision Medicine for Ischemic Cerebrovascular Diseases
- Author
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Nobuhito Saito, Satoru Miyawaki, and Hideaki Imai
- Subjects
medicine.medical_specialty ,business.industry ,Medicine ,Surgery ,Neurology (clinical) ,business ,Intensive care medicine ,Precision medicine - Published
- 2018
24. Correction to: RNF213 p.Arg4810Lys Heterozygosity in Moyamoya Disease Indicates Early Onset and Bilateral Cerebrovascular Events
- Author
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Masahiro Shimizu, Yu Teranishi, Hirofumi Nakatomi, Yudai Hirano, Daisuke Shimada, Hiroki Hongo, Nobuhito Saito, Hideaki Imai, Hideaki Ono, Shogo Dofuku, Kenta Ohara, Daiichiro Ishigami, Satoru Miyawaki, Masafumi Segawa, and Satoshi Koizumi
- Subjects
Loss of heterozygosity ,Pediatrics ,medicine.medical_specialty ,business.industry ,General Neuroscience ,MEDLINE ,Medicine ,Neurology (clinical) ,Moyamoya disease ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Early onset - Published
- 2021
25. EPCO-01. MOLECULAR PROFILING OF SPINAL CORD EPENDYMOMA
- Author
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Fumi Higuchi, Erika Yamazawa, Kazuha Kugasawa, Hideaki Imai, Tsukasa Koike, Yoshihiro Kushihara, Taijun Hana, Reiko Matsuura, Toshihiro Takami, Shohei Nambu, Kazuhiko Ishii, Hirokazu Takami, Hiroyuki Aburatani, Phyo Kim, Nobuhito Saito, Shota Tanaka, Yuta Nakanishi, Genta Nagae, Akitake Mukasa, Takashi Komori, Shunsaku Takayanagi, Takayoshi Umeda, Keisuke Takai, and Masashi Nomura
- Subjects
Ependymoma ,Cancer Research ,Spinal Cord Ependymoma ,Methylation ,26th Annual Meeting & Education Day of the Society for Neuro-Oncology ,Ribosomal RNA ,Biology ,Spinal cord ,medicine.disease ,medicine.anatomical_structure ,Oncology ,DNA methylation ,Cancer research ,medicine ,Neurology (clinical) ,Epigenetics ,Epigenomics - Abstract
BACKGROUND Ependymomas are currently classified into 9 subgroups by DNA methylation profiles. Although spinal cord ependymoma (SP-EPN) is distinct from other tumors, diversity within SP-EPN is still unclear. Here, we used transcriptomic and epigenomic profiles to investigate the diversity among Japanese SP-EPN cases. MATERIALS AND METHODS We analyzed 57 SP-EPN patients (32 males and 25 females, aged from 18 to 78 years, median: 52), including two cases of neurofibromatosis type 2, five cases of grade 3 (WHO grade). We obtained transcriptome (RNA-seq) and DNA methylation (Infinium Methylation EPIC array) data from fresh frozen specimens of SP-EPN resected at the University of Tokyo Hospital and our collaborative groups. RESULTS Three cases had a previous intracranial ependymoma operation. Hierarchical clustering of the DNA methylation data showed that these three cases of intracranial origin as a different cluster from spinal origin. The 45 grade 2 spinal ependymoma showed a relatively homogenous methylation pattern. However, the methylation status of HOX gene cluster regions is compatible with the segment of origin, which reflects the cells of origins are derived after the determination of segment identity. RNA sequencing of 57 cases revealed two subgroups within grade 2. Gene ontology analysis of differentially expressed genes suggested the difference in metabolic state such as rRNA translation and mitochondrial respiration between the two expression subgroups. CONCLUSION Epigenetic analysis indicated the accurate body segment origin of SP-EPN. We observed that metabolic states could divide grade 2 spinal cord ependymoma into 2 subgroups and will present the relationship to clinicopathological information.
- Published
- 2021
26. Spinal extradural arteriovenous fistulas with retrograde intradural venous drainage: Diagnostic features in digital subtraction angiography and time-resolved magnetic resonance angiography
- Author
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Hirofumi Nakatomi, Akira Kunimatsu, Kazuhiko Ishii, Hideaki Imai, Satoshi Koizumi, Keisuke Takai, Masaaki Shojima, and Nobuhito Saito
- Subjects
Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Fistula ,Magnetic resonance angiography ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,medicine ,Medical imaging ,Humans ,cardiovascular diseases ,Aged ,Retrospective Studies ,Aged, 80 and over ,Central Nervous System Vascular Malformations ,medicine.diagnostic_test ,business.industry ,Angiography, Digital Subtraction ,Venous drainage ,Magnetic resonance imaging ,General Medicine ,Digital subtraction angiography ,Middle Aged ,medicine.disease ,Spinal cord ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Spinal Cord ,Neurology ,Angiography ,Drainage ,Female ,Surgery ,Neurology (clinical) ,Radiology ,business ,Magnetic Resonance Angiography ,030217 neurology & neurosurgery - Abstract
Spinal extradural arteriovenous fistulas (AVFs) may be more difficult to prospectively identify than dural AVFs because they are less common than dural AVFs. The primary purpose was to further characterize the diagnostic imaging of spinal extradural AVFs with intradural retrograde venous drainage. The magnetic resonance (MR) imaging and angiographic results of 23 patients with suspected spinal dural AVFs were analyzed in order to distinguish dural and extradural AVFs. The diagnostic accuracy of MR angiography was retrospectively compared between dural and extradural AVFs. All 23 patients showed high intensity in the spinal cord on T2-weighted MR images. Eighteen out of 23 patients were diagnosed with dural AVFs, while the remaining 5 were diagnosed with extradural AVFs by angiography. Extradural AVFs were fed by a branch of the segmental artery to the vertebral body, characterized by a fistula located in the ventral extradural space, and drained retrogradely via an epidural venous pouch into intradural veins. The segmental artery was localized within 1 vertebral level using MRA in 12 out of 18 patients (67%) with dural AVFs and in 1 out of 5 patients (20%) with extradural AVFs (p=0.09). The reasons behind the lower accuracy was mainly the image misinterpretation. Congestion of the spinal cord in spinal extradural AVFs with intradural retrograde venous drainage was similar to that in dural AVFs, whereas its angioarchitecture differed from that of dural AVFs. A clearer understanding of the imaging features of extradural AVFs is important for improving the diagnostic accuracy and clarifying treatment targets.
- Published
- 2017
27. Microsurgery Simulator of Cerebral Aneurysm Clipping with Interactive Cerebral Deformation Featuring a Virtual Arachnoid
- Author
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Toki Saito, Seiji Nomura, Hiroshi Oyama, Nobuhito Saito, Naoyuki Shono, Satoru Miyawaki, Hideaki Imai, Taichi Kin, and Hirofumi Nakatomi
- Subjects
Adult ,Male ,Microsurgery ,medicine.medical_treatment ,Virtual reality ,Neurosurgical Procedures ,Computer graphics ,Motion ,User-Computer Interface ,03 medical and health sciences ,0302 clinical medicine ,Aneurysm ,Computer Systems ,Surveys and Questionnaires ,Computer Graphics ,medicine ,Humans ,Computer Simulation ,Simulation Training ,Simulation ,Aged ,Aged, 80 and over ,business.industry ,Dissection ,Virtual Reality ,Brain ,Intracranial Aneurysm ,Clipping (medicine) ,Middle Aged ,medicine.disease ,Visualization ,Neurosurgeons ,Arachnoid mater ,030220 oncology & carcinogenesis ,Female ,Surgery ,Arachnoid Membrane ,Neurology (clinical) ,Arachnoid ,business ,Vascular Surgical Procedures ,030217 neurology & neurosurgery - Abstract
BACKGROUND A virtual reality simulator for aneurysmal clipping surgery is an attractive research target for neurosurgeons. Brain deformation is one of the most important functionalities necessary for an accurate clipping simulator and is vastly affected by the status of the supporting tissue, such as the arachnoid membrane. However, no virtual reality simulator implementing the supporting tissue of the brain has yet been developed. OBJECTIVE To develop a virtual reality clipping simulator possessing interactive brain deforming capability closely dependent on arachnoid dissection and apply it to clinical cases. METHODS Three-dimensional computer graphics models of cerebral tissue and surrounding structures were extracted from medical images. We developed a new method for modifiable cerebral tissue complex deformation by incorporating a nonmedical image-derived virtual arachnoid/trabecula in a process called multitissue integrated interactive deformation (MTIID). MTIID made it possible for cerebral tissue complexes to selectively deform at the site of dissection. Simulations for 8 cases of actual clipping surgery were performed before surgery and evaluated for their usefulness in surgical approach planning. RESULTS Preoperatively, each operative field was precisely reproduced and visualized with the virtual brain retraction defined by users. The clear visualization of the optimal approach to treating the aneurysm via an appropriate arachnoid incision was possible with MTIID. CONCLUSION A virtual clipping simulator mainly focusing on supporting tissues and less on physical properties seemed to be useful in the surgical simulation of cerebral aneurysm clipping. To our knowledge, this article is the first to report brain deformation based on supporting tissues.
- Published
- 2017
28. Usefulness of high-resolution 3D multifusion medical imaging for preoperative planning in patients with posterior fossa hemangioblastoma: technical note
- Author
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Masanori Yoshino, Seiji Nomura, Nobuhito Saito, Naoyuki Shono, Toki Saito, Hiroshi Oyama, Taichi Kin, Shunsaku Takayanagi, Hideaki Imai, Hirofumi Nakatomi, and Daichi Nakagawa
- Subjects
Adult ,Male ,medicine.medical_specialty ,Posterior fossa ,High resolution ,Infratentorial Neoplasms ,Neuroimaging ,Multimodal Imaging ,Neurosurgical Procedures ,Patient Care Planning ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Hemangioblastoma ,Preoperative Care ,medicine ,Medical imaging ,Humans ,In patient ,Aged ,Preoperative planning ,medicine.diagnostic_test ,business.industry ,Technical note ,General Medicine ,medicine.disease ,030220 oncology & carcinogenesis ,Angiography ,Female ,Radiology ,business ,030217 neurology & neurosurgery - Abstract
Successful resection of hemangioblastoma depends on preoperative assessment of the precise locations of feeding arteries and draining veins. Simultaneous 3D visualization of feeding arteries, draining veins, and surrounding structures is needed. The present study evaluated the usefulness of high-resolution 3D multifusion medical imaging (hr-3DMMI) for preoperative planning of hemangioblastoma. The hr-3DMMI combined MRI, MR angiography, thin-slice CT, and 3D rotated angiography. Surface rendering was mainly used for the creation of hr-3DMMI using multiple thresholds to create 3D models, and processing took approximately 3–5 hours. This hr-3DMMI technique was used in 5 patients for preoperative planning and the imaging findings were compared with the operative findings. Hr-3DMMI could simulate the whole 3D tumor as a unique sphere and show the precise penetration points of both feeding arteries and draining veins with the same spatial relationships as the original tumor. All feeding arteries and draining veins were found intraoperatively at the same position as estimated preoperatively, and were occluded as planned preoperatively. This hr-3DMMI technique could demonstrate the precise locations of feeding arteries and draining veins preoperatively and estimate the appropriate route for resection of the tumor. Hr-3DMMI is expected to be a very useful support tool for surgery of hemangioblastoma.
- Published
- 2017
29. Genetic analysis of intracranial major artery stenosis: Analysis of moyamoya disease associated gene RNF213
- Author
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Nobuhito Saito, Satoru Miyawaki, and Hideaki Imai
- Subjects
medicine.medical_specialty ,Stenosis ,Major artery ,business.industry ,Internal medicine ,medicine ,Cardiology ,General Medicine ,Moyamoya disease ,medicine.disease ,business ,Genetic analysis ,Gene - Published
- 2017
30. Wall-to-lumen ratio of intracranial arteries measured by indocyanine green angiography
- Author
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Nobuhito Saito, Hiroshi Oyama, Toki Saito, Daichi Nakagawa, Hideaki Imai, Masaaki Shojima, Taichi Kin, Masanori Yoshino, Seiji Nomura, and Hirofumi Nakatomi
- Subjects
medicine.medical_specialty ,vascular wall ,medicine.medical_treatment ,Lumen (anatomy) ,030204 cardiovascular system & hematology ,intracranial artery ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,In vivo ,Medical imaging ,Medicine ,medicine.diagnostic_test ,business.industry ,Intracranial Artery ,General Medicine ,wall-to-lumen ratio ,Microsurgery ,medicine.disease ,normal ,Stenosis ,chemistry ,Angiography ,Original Article ,Radiology ,business ,Operating microscope ,Indocyanine green ,indocyanine green angiography ,030217 neurology & neurosurgery - Abstract
Background: The wall-to-lumen ratio (WLR) is an important parameter in vascular medicine because it indicates the character of vascular wall as well as the degree of stenosis. Despite the advances in medical imaging technologies, it is still difficult to measure the thin-walled normal intracranial arteries, and the reports on the WLR of normal intracranial artery are limited. It might be possible to calculate the WLR using the indocyanine green (ICG) angiography, which is used to observe intracranial vessels during microsurgery. Purpose: To evaluate the WLR of normal intracranial arteries using ICG angiography. Materials and Methods: From the three cases in which ICG angiography was recorded with a ruler during microsurgery, 20 measurement points were chosen for the analysis. The ICG was injected intravenously with a dose of 0.2 mg/kg, and the vessels were inspected at high magnification using an operating microscope equipped with near-infrared illumination system. The vessel outer diameter and the luminal diameter were measured using the images before and after the ICG arrival based on the pixel ratio method using a ruler as reference, respectively. The WLR was calculated as 0.5 × (vessel outer diameter − vessel luminal diameter). Results: The WLR (mean ± standard deviation) of normal intracranial arteries was 0.086 ± 0.022. The WLR tended to be high in small arteries. Conclusion: The WLR of normal intracranial arteries calculated using ICG angiography was consistent with the WLR reported in the previous reports based on human autopsy.
- Published
- 2016
31. Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle
- Author
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Keiji Itaka, Nobuhito Saito, Hirofumi Nakatomi, Kazunori Kataoka, Satoshi Uchida, Hideaki Imai, and Yuta Fukushima
- Subjects
Biophysics ,Ischemia ,Hippocampus ,Bioengineering ,02 engineering and technology ,Pharmacology ,Hippocampal formation ,Biomaterials ,03 medical and health sciences ,Neurotrophic factors ,medicine ,Animals ,RNA, Messenger ,030304 developmental biology ,Brain-derived neurotrophic factor ,0303 health sciences ,Messenger RNA ,Cell Death ,business.industry ,Brain-Derived Neurotrophic Factor ,021001 nanoscience & nanotechnology ,medicine.disease ,Rats ,medicine.anatomical_structure ,nervous system ,Mechanism of action ,Mechanics of Materials ,Ceramics and Composites ,medicine.symptom ,0210 nano-technology ,business ,Astrocyte - Abstract
Ischemic neuronal death causes serious lifelong neurological deficits; however, there is no proven effective treatment that can prevent neuronal death after the ischemia. We investigated the feasibility of mRNA therapeutics for preventing the neuronal death in a rat model of transient global ischemia (TGI). By intraventricular administration of mRNA encoding brain-derived neurotrophic factor (BDNF) using a polymer-based carrier, polyplex nanomicelle, the mRNA significantly increased the survival rate of hippocampal neurons after TGI, with a rapid rise of BDNF in the hippocampus. Interestingly, mRNA administration on Day 2 after TGI provided significantly better survival rate than the administration immediately after TGI. Eventually, dosing twice on Day 2 and 5 exerted long-term therapeutic effects, which were confirmed by a Y-maze behavioral test demonstrating improved spatial memory compared with untreated rats on Day 20. Immunohistochemical analysis showed that astrocytes were chief targets of the BDNF mRNA-loaded nanomicelles, suggesting that the augmented BDNF secretion from astrocytes creates a supportive microenvironment for the neurons to tolerate changes caused by ischemic stresses, and terminate the process of progressive neuronal death after the ischemic attack. Overall, the unique mechanism of action of mRNA therapeutics provide a promising approach for preventing ischemic neuronal death.
- Published
- 2021
32. Conducting thin films of pentacene doped with alkaline metals
- Author
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Takashi Minakata, Masaru Ozaki, and Hideaki Imai
- Subjects
Thin films -- Electric properties ,Semiconductor doping -- Methods ,Physics - Abstract
Alkalene metals such as sodium, potassium and rubidium were used for the donor doping of thin films of pentacene (PEN). The doping causes changes in conductivities of PEN films from an insulator to an n-type semiconductor. The film doped with rubidium had the maximum conductivity of 2. 8 per ohm per centimeter. Thin films of other acene compounds, such as tetracene and hexacene, were doped with alkaline metals.
- Published
- 1993
33. The outcome of a surgical protocol based on ischemia overprotection in large and giant aneurysms of the anterior cerebral circulation
- Author
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Katsushige Watanabe, Takaaki Miyagishima, Taichi Kin, Hirofumi Nakatomi, Nobuhito Saito, Yuhei Yoshimoto, and Hideaki Imai
- Subjects
Adult ,Carotid Artery Diseases ,Male ,medicine.medical_specialty ,Microsurgery ,Middle Cerebral Artery ,Anterior Cerebral Artery ,Decompression ,medicine.medical_treatment ,Bypass ,Ischemia ,Clinical Neurology ,Neurosurgical Procedures ,030218 nuclear medicine & medical imaging ,Brain Ischemia ,03 medical and health sciences ,Cerebral circulation ,0302 clinical medicine ,medicine.artery ,Occlusion ,medicine ,Humans ,Perforating artery ,Motor evoked potential ,Aged ,Intracavernous aneurysm ,business.industry ,Glasgow Outcome Scale ,Intracranial Aneurysm ,General Medicine ,Clipping (medicine) ,Giant/large cerebral aneurysm ,Middle Aged ,medicine.disease ,Surgical Instruments ,Surgery ,Cerebral Angiography ,Treatment Outcome ,Bypass surgery ,Anesthesia ,Cerebrovascular Circulation ,Original Article ,Female ,Neurology (clinical) ,Internal carotid artery ,business ,030217 neurology & neurosurgery - Abstract
Aiming to define the optimal treatment of large and giant aneurysms (LGAs) in the anterior circulation, we present our surgical protocol and patient outcome. A series of 42 patients with intracavernous LGAs (n = 16), paraclinoid (C2) LGAs (n = 17), and peripheral (middle cerebral artery—MCA or anterior cerebral artery—ACA) LGAs (n = 9) were treated after bypass under motor evoked potential (MEP) monitoring. Preoperatively, three categories of ischemic tolerance during internal carotid artery (ICA) occlusion were defined on conventional angiography: optimal, suboptimal, and insufficient collaterals. Accordingly, three types of bypass: low flow (LFB), middle flow (MFB) and high flow (HFB) were applied for the cases with optimal, suboptimal, and insufficient collaterals, respectively. Outcome was evaluated by the Glasgow Outcome Scale (GOS). All patients had excellent GOS score except one, who suffered a major ischemic stroke immediately after surgery for a paraclinoid lesion. Forty-one patients were followed up for 87.1 ± 40.1 months (range 13–144 months). Intracavernous LGAs were all treated by proximal occlusion with bypass surgery. Of paraclinoid LGA patients, 15 patients had direct clipping under suction decompression and other 2 patients with recurrent aneurysms had ICA (C2) proximal clipping with HFB. MEP monitoring guided for temporary clipping time and clip repositioning, observing significant MEP changes for up to 6 min duration. Of 9 peripheral LGAs patients 7 MCA LGAs had reconstructive clipping (n = 4) or trapping (n = 3) with bypass including LFB in 3 cases, MFB in 1 and HFB in 1. Two ACA LGAs had clipping (n = 1) or trapping (n = 1) with A3-A3 bypass. The applied protocol provided excellent results in intracavernous, paraclinoid, and peripheral thrombosed LGAs of the anterior circulation.
- Published
- 2016
34. Temporal changes in the response of SVZ neural stem cells to intraventricular administration of growth factors
- Author
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Akihiro Ito, Shigeo Okabe, Nobuhito Saito, Takashi Ochi, Hirofumi Nakatomi, and Hideaki Imai
- Subjects
Male ,0301 basic medicine ,Time Factors ,Neurogenesis ,Cellular differentiation ,medicine.medical_treatment ,Subventricular zone ,Cell Count ,Biology ,Fibroblast growth factor ,Sodium Channels ,Mice ,03 medical and health sciences ,Neural Stem Cells ,Tubulin ,Epidermal growth factor ,Lateral Ventricles ,Glial Fibrillary Acidic Protein ,In Situ Nick-End Labeling ,medicine ,Animals ,Molecular Biology ,reproductive and urinary physiology ,Adaptor Proteins, Signal Transducing ,Injections, Intraventricular ,SOXB1 Transcription Factors ,General Neuroscience ,Growth factor ,Cell Differentiation ,Olfactory Bulb ,Neural stem cell ,nervous system diseases ,Olfactory bulb ,Cell biology ,Mice, Inbred C57BL ,Ki-67 Antigen ,030104 developmental biology ,medicine.anatomical_structure ,Bromodeoxyuridine ,nervous system ,Phosphopyruvate Hydratase ,Intercellular Signaling Peptides and Proteins ,Neurology (clinical) ,biological phenomena, cell phenomena, and immunity ,Neuroscience ,Developmental Biology - Abstract
In vivo growth factor (GF) treatment is a promising approach to enhance the regenerative capacity of neural stem cells (NSCs) for brain repair. However, how exogenous GFs affect endogenous NSCs is not well understood. This study investigated the impact of intraventricular administration of fibroblast growth factor 2 and epidermal growth factor on NSCs in the subventricular zone of intact adult mice. GFs were administered for various periods (3, 7, 10, and 14 days), and the proliferation and neuronal production of NSCs were assessed during and after GF treatment. We found that proliferation of NSCs and their progeny is markedly augmented during the first 7 days after the initiation of GF treatment. GF treatment for longer periods, however, did not lead to further increases in the NSC pool, but rather attenuated such proliferation and inhibited neurogenesis. As a result, the production of new olfactory bulb neurons was increased in animals treated with GFs for 7 days but decreased in animals treated for 14 days. These results show time-dependent changes in the response of NSCs to exogenous GFs and demonstrate that precise control of the duration of GF treatment is important for significant enhancement of neuronal production by NSCs in vivo for brain repair.
- Published
- 2016
35. Dorsal Forebrain-Specific Deficiency of Reelin-Dab1 Signal Causes Behavioral Abnormalities Related to Psychiatric Disorders
- Author
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Kenji Sakimura, Toshio Terashima, Masaki Ogata, Yu Katsuyama, Hideaki Imai, Hirotaka Shoji, Tsuyoshi Miyakawa, Yoshiteru Kagawa, and Yuji Owada
- Subjects
Male ,0301 basic medicine ,Reflex, Startle ,medicine.medical_specialty ,Cell Adhesion Molecules, Neuronal ,Cognitive Neuroscience ,Hippocampus ,Nerve Tissue Proteins ,Motor Activity ,Mice ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Conditional gene knockout ,medicine ,Animals ,Reelin ,Maze Learning ,Psychiatry ,Mice, Knockout ,Extracellular Matrix Proteins ,Memory Disorders ,Behavior, Animal ,biology ,Cerebellar ataxia ,business.industry ,Mental Disorders ,Serine Endopeptidases ,Immobility Response, Tonic ,Fear ,medicine.disease ,DAB1 ,Adaptation, Physiological ,Mice, Inbred C57BL ,Disease Models, Animal ,Reelin Protein ,030104 developmental biology ,nervous system ,Schizophrenia ,Forebrain ,Exploratory Behavior ,biology.protein ,Cerebellar atrophy ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
Reelin-Dab1 signaling is involved in brain development and neuronal functions. The abnormalities in the signaling through either reduction of Reelin and Dab1 gene expressions or the genomic mutations in the brain have been reported to be associated with psychiatric disorders. However, it has not been clear if the deficiency in Reelin-Dab1 signaling is responsible for symptoms of the disorders. Here, to examine the function of Reelin-Dab1 signaling in the forebrain, we generated dorsal forebrain-specific Dab1 conditional knockout mouse (Dab1 cKO) and performed a behavioral test battery on the Dab1 cKO mice. Although conventional Dab1 null mutant mice exhibit cerebellar atrophy and cerebellar ataxia, the Dab1 cKO mice had normal cerebellum and showed no motor dysfunction. Dab1 cKO mice exhibited behavioral abnormalities, including hyperactivity, decreased anxiety-like behavior, and impairment of working memory, which are reminiscent of symptoms observed in patients with psychiatric disorders such as schizophrenia and bipolar disorder. These results suggest that deficiency of Reelin-Dab1 signal in the dorsal forebrain is involved in the pathogenesis of some symptoms of human psychiatric disorders.
- Published
- 2016
36. Rat white matter injury model induced by endothelin-1 injection: technical modification and pathological evaluation
- Author
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Hideaki Imai, Nobuhito Saito, Hideaki Ono, Satoru Miyawaki, and Hirofumi Nakatomi
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Time Factors ,Internal capsule ,Stilbamidines ,Ischemia ,Poison control ,Functional Laterality ,Rats, Sprague-Dawley ,White matter ,Lesion ,Amyloid beta-Protein Precursor ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,lacunar infarction ,Internal Capsule ,Leukoencephalopathies ,Glial Fibrillary Acidic Protein ,medicine ,Animals ,Swimming ,Neurologic Examination ,Hydroxystilbamidine ,Endothelin-1 ,medicine.diagnostic_test ,business.industry ,rat model ,General Neuroscience ,Magnetic resonance imaging ,General Medicine ,Ectodysplasins ,medicine.disease ,Magnetic Resonance Imaging ,Rats ,Disease Models, Animal ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Gliosis ,white matter injury ,histopathology ,retrograde tracing ,medicine.symptom ,business ,Locomotion ,Psychomotor Performance ,030217 neurology & neurosurgery - Abstract
White matter injury is an important cause of functional disability of the brain. We comprehensively analyzed a modified endothelin-1 (ET-1) injection-induced white matter injury model in the rat which is very valuable for investigating the underlying mechanisms of subcortical ischemic stroke. ET-1 was stereotactically injected into the internal capsule of the rat. To avoid complications with leakage of ET-1 into the lateral ventricle, the safest trajectory angle to the target was established. Rats with white matter injury were extensively evaluated for structural changes and functional sequelae, using motor function tests, magnetic resonance (MR) imaging, histopathology evolution, volume estimation of the lesion, and neuroanatomical identification of affected neurons using the retrograde tracer hydroxystilbamidine. Optimization of the trajectory of the ET-1 injection needle provided excellent survival rate. MR imaging visualized the white matter injury 2 days after surgery. Motor function deficit appeared temporarily after the operation. Histological studies confirmed damage of axons and myelin sheaths followed by inflammatory reaction and gliosis similar to lacunar infarction, with lesion volume of less than 1% of the whole brain. Hydroxystilbamidine injected into the lesion revealed wide spatial distribution of the affected neuronal population. Compared with prior ET 1 injection models, this method induced standardized amount of white matter damage and temporary motor function deficit in a reproducible and safe manner. The present model is valuable for studying the pathophysiology of not only ischemia, but a broader set of white matter damage conditions in the lissencephalic brain.
- Published
- 2016
37. Surgical management for a huge presacral teratoma and a meningocele in an adult with Currarino triad: a case report
- Author
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Kazushige Kawai, Tetsuo Ushiku, Keisuke Hata, Toshiaki Tanaka, Manabu Kaneko, Koji Murono, Sakae Tanaka, Hideaki Imai, Kazuhito Sasaki, Nobuhito Saito, Takeshi Nishikawa, Hiroshi Kobayashi, Kensuke Otani, Shigenobu Emoto, Hiroaki Nozawa, and Masako Ikemura
- Subjects
medicine.medical_specialty ,business.industry ,Presacral teratoma ,lcsh:Surgery ,Currarino triad ,Case Report ,lcsh:RD1-811 ,Meningocele ,Posterior approach ,Surgery ,03 medical and health sciences ,Triad (sociology) ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Presacral mass ,030211 gastroenterology & hepatology ,business - Abstract
Background The Currarino triad is a rare hereditary syndrome comprising anorectal malformation, sacral bony defect, and presacral mass. Most of the patients are diagnosed during infancy. Case presentation A 44-year-old man was diagnosed with Currarino triad, with a huge presacral teratoma and meningocele. One-stage surgery via posterior approach was successful. Conclusions Treatment of the presacral mass in the Currarino triad, diagnosed in adulthood, is challenging. Multidisciplinary management and detailed planning before surgery are important for a satisfactory outcome.
- Published
- 2017
38. Response to Letter to the Editor Regarding 'Genetic Analysis of Ring Finger Protein 213 (RNF213) c.14576G>A in Intracranial Atherosclerosis of the Anterior and Posterior Circulations'
- Author
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Yuki Shinya, Akira Teraoka, Hirofumi Nakatomi, Hideaki Ono, Atsumi Takenobu, Hideaki Imai, Satoru Miyawaki, Hiroki Hongo, and Nobuhito Saito
- Subjects
Letter to the editor ,business.industry ,Rehabilitation ,Neural crest ,Medicine ,Surgery ,Neurology (clinical) ,Intracranial Atherosclerosis ,Anatomy ,Cardiology and Cardiovascular Medicine ,business ,Genetic analysis ,Ring Finger Protein 213 - Published
- 2018
39. Cell Therapy for Chronic TBI: Interim Analysis of the Randomized Controlled STEMTRA Trial.
- Author
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Masahito Kawabori, Weintraub, Alan H., Hideaki Imai, Zinkevych, Iaroslav, McAllister, Peter, Steinberg, Gary K., Frishberg, Benjamin M., Takao Yasuhara, Chen, Jefferson W., Cramer, Steven C., Achrol, Achal S., Schwartz, Neil E., Suenaga, Jun, Lu, Daniel C., Semeniv, Ihor, Hajime Nakamura, Kondziolka, Douglas, Dai Chida, Takehiko Kaneko, and Yasuaki Karasawa
- Published
- 2021
- Full Text
- View/download PDF
40. Microsurgical and Endovascular Treatments of Spinal Extradural Arteriovenous Fistulas with or without Intradural Venous Drainage
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Masaaki Shojima, Hideaki Imai, Makoto Taniguchi, Keisuke Takai, and Nobuhito Saito
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Adult ,Male ,medicine.medical_specialty ,Microsurgery ,medicine.medical_treatment ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Myelopathy ,Young Adult ,0302 clinical medicine ,Occlusion ,medicine ,Humans ,Vein ,Gait Disorders, Neurologic ,Aged ,Retrospective Studies ,Aged, 80 and over ,Paraplegia ,Neck Pain ,business.industry ,Endovascular Procedures ,Venous plexus ,Arteriovenous malformation ,Middle Aged ,medicine.disease ,Venous lake ,Surgery ,Cerebral Angiography ,medicine.anatomical_structure ,Treatment Outcome ,Arteriovenous Fistula ,Drainage ,Female ,Neurology (clinical) ,Dura Mater ,Nervous System Diseases ,business ,030217 neurology & neurosurgery ,Lumbosacral joint ,Follow-Up Studies - Abstract
Objective To present treatment strategies for spinal extradural arteriovenous fistulas (AVFs) in relation to angioarchitecture. Methods A retrospective analysis comprising 14 patients treated at 2 hospitals was performed. Results The 14 AVFs included 4 cervical, 1 thoracic, and 9 lumbosacral lesions. Three key angiographic features were observed: the feeding artery, an enlarged extradural venous plexus, and intradural retrograde venous drainage. In 3 patients (3 cervical AVFs) with compressive myelopathy owing to an enlarged venous plexus, the treatment goal was mass reduction of the venous plexus. Combined endovascular and microsurgical treatments may be curative for a large venous lake with multiple feeders. No intradural procedure was required because of the absence of intradural venous drainage. In contrast, in the other 11 patients (1 cervical, 1 thoracic, and 9 lumbosacral AVFs) with congestive myelopathy owing to intradural retrograde venous drainage, the goal of treatment was occlusion of the intradural proximal vein. Microsurgery or endovascular treatment may be curative by itself for a small venous pouch with a single intradural draining vein. Extradural procedures were not required in most patients treated by microsurgery because the extradural venous plexus was small. In all 14 patients, neurologic deficits improved or stabilized, and no recurrence was noted in the follow-up period (29 months). Conclusions Spinal extradural AVFs consist of 2 subtypes—type A with intradural drainage and type B without intradural drainage—characterized by regional differences at each spinal level in angioarchitecture, causes of myelopathy, and treatment goals.
- Published
- 2017
41. Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431)
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Akira Kunimatsu, Harushi Mori, Hideaki Imai, Satoru Miyawaki, Yuki Shinya, Hideaki Ono, Hiroki Hongo, Nobuhito Saito, and Hirofumi Nakatomi
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medicine.medical_specialty ,Outer diameter ,magnetic resonance imaging (MRI) ,030204 cardiovascular system & hematology ,Neurovascular: Original Article ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine.artery ,Occlusion ,medicine ,genetics ,intracranial artery stenosis ,remodeling ,medicine.diagnostic_test ,RNF213 ,Variant type ,business.industry ,Magnetic resonance imaging ,medicine.disease ,Atherosclerosis ,Stenosis ,Middle cerebral artery ,Cardiology ,Surgery ,Neurology (clinical) ,Intracranial Atherosclerosis ,business ,030217 neurology & neurosurgery ,Ring Finger Protein 213 - Abstract
Background Intracranial atherosclerosis (ICAS) involves diverse histologies and several remodeling patterns. Ring finger protein 213 (RNF213) c.14576G>A variant (rs112735431), recently reported to be associated with ICAS, may be linked with negative remodeling (outer diameter - reducing morphological alteration) of intracranial arteries. This study investigated the outer diameter of atherosclerotic middle cerebral artery (MCA). Methods Patients with unilateral atherosclerotic MCA stenosis/occlusion were enrolled in this single-hospital-based case-control study at The University of Tokyo Hospital. The patients were divided into two groups by the presence of RNF213 c.14576G>A (variant group and wild-type group) and the outer diameter of the MCA was measured with high-resolution magnetic resonance imaging. Results Twenty-eight patients with the wild type and 19 patients with the variant type were included. The outer diameter of the stenotic side MCA was smaller in the variant group than in the wild-type group (P = 8.3 × 10-6). The outer diameter of the normal side MCA was also smaller in the variant group than in the wild-type group (P = 5.2 × 10-3). The ratio of stenotic side to normal side was also smaller in the variant group than in the wild-type group (P = 1.5 × 10-5). Conclusions This study indicates that RNF213 c.14576G>A is associated with negative remodeling of ICAS.
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- 2017
42. Vascular Diseases Attributable to RNF213 Other Than Moyamoya Disease
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Nobuhito Saito, Hideaki Imai, and Satoru Miyawaki
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medicine.medical_specialty ,education.field_of_study ,business.industry ,Population ,Fibromuscular dysplasia ,030204 cardiovascular system & hematology ,medicine.disease ,Pathophysiology ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,Aneurysm ,Internal medicine ,medicine ,Cardiology ,Intracranial Atherosclerosis ,Moyamoya disease ,Genetic risk ,education ,business ,030217 neurology & neurosurgery - Abstract
Ring finger protein 213 (RNF213) has been reported to have association with various vascular diseases other than moyamoya disease (MMD). MMD-associated genetic variant RNF213 c.14576G>A had association with various degrees of intracranial major artery stenotic lesions including intracranial atherosclerosis (ICAS). RNF213 c.14576G>A could be the candidate genetic variant for this prevalence of ICAS in East Asian population. The presence of RNF213 c.14576G>A may associate with high blood pressure. Thus, RNF213 c.14576G>A could be a robust genetic risk indicator for ischemic stroke in East Asian population. RNF213 c.14576G>A may also have some association with quasi-MMD in East Asian population. Associations of RNF213 with fibromuscular dysplasia and intracranial aneurysm have also been reported in European population. These results indicate that RNF213 has a fundamental role in the pathophysiology of various vascular diseases.
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- 2017
43. Definitions and Properties of (Local) Minima and Multimodal Functions using Level Set for Continuous Optimization Problems
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Hideaki Imai, Hideo Kanemitsu, and Masaaki Miyaskoshi
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Continuous optimization ,Maxima and minima ,Mathematical optimization ,Level set (data structures) ,Computer science - Published
- 2014
44. Pre- and Intraoperative Brain Functional Mapping in Brain Tumor Surgery
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Hirofumi Nakatomi, Akira Kunimatsu, Nobuhito Saito, Akitake Mukasa, Toki Saito, Masahiro Shin, Taichi Kin, Masanori Yoshino, Hideaki Imai, Masaaki Shojima, Daichi Nakagawa, and Hiroshi Oyama
- Subjects
medicine.medical_specialty ,Functional mapping ,business.industry ,Medicine ,Surgery ,Neurology (clinical) ,Radiology ,business ,Brain tumor surgery - Published
- 2014
45. Genetic Analysis of Ring Finger Protein 213 (RNF213) c.14576GA in Intracranial Atherosclerosis of the Anterior and Posterior Circulations
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Akira Teraoka, Satoru Miyawaki, Hideaki Imai, Hiroki Hongo, Hideaki Ono, Nobuhito Saito, Yuki Shinya, Atsumi Takenobu, and Hirofumi Nakatomi
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Male ,medicine.medical_specialty ,Anterior Cerebral Artery ,Genotype ,Ubiquitin-Protein Ligases ,030204 cardiovascular system & hematology ,Genetic analysis ,Polymorphism, Single Nucleotide ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Gene Frequency ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Moyamoya disease ,Genetic Testing ,Stroke ,Aged ,Adenosine Triphosphatases ,Aged, 80 and over ,Posterior Cerebral Artery ,business.industry ,Rehabilitation ,Odds ratio ,Middle Aged ,medicine.disease ,Intracranial Arteriosclerosis ,Magnetic Resonance Imaging ,Confidence interval ,Surgery ,Genetic epidemiology ,Case-Control Studies ,cardiovascular system ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery ,Ring Finger Protein 213 ,Magnetic Resonance Angiography - Abstract
Background Intracranial atherosclerosis of the anterior circulation (anterior ICAS) and intracranial atherosclerosis of the posterior circulation (posterior ICAS) are thought to involve different pathogeneses and risk factors. Recently, we identified a genetic variant that has a significant association with ICAS. The variant was ring finger protein 213 (RNF213) c.14576G>A (rs112735431), which was originally identified as a susceptibility genetic variant for moyamoya disease (MMD). The present study investigated the association of RNF213 c.14576G>A with anterior and posterior ICAS. Materials and Methods A total of 221 study participants (43 with anterior ICAS, 61 with posterior ICAS, 12 with extracranial carotid atherosclerosis [ECAS], 5 with MMD, and 100 control subjects) were recruited from April 2015 to October 2015. A genetic analysis of RNF213 c.14576G>A and an association study with these cerebrovascular diseases were performed. Results RNF213 c.14576G>A was present in 10 of 43 patients in the anterior ICAS group and 4 of 5 patients in the MMD group, but was not present in the patients in the posterior ICAS and ECAS groups. c.14576G>A was found in 2 of 100 patients in the control group. RNF213 c.14576G>A showed a significant association with anterior ICAS (allele count: P = 3.9 × 10−5, odds ratio [OR] = 13.0, 95% confidence interval [CI] = 2.8-60.8; prevalence of carriers of c.14576G>A: P = 2.6 × 10−5, OR = 14.8, 95% CI = 3.1-71.3). However, RNF213 c.14576G>A showed no association with posterior ICAS. RNF213 c.14576G>A also had a significant association with MMD and had no association with ECAS. Conclusions The genetic variant RNF213 c.14576G>A is significantly associated with anterior ICAS but not with posterior ICAS. The present findings may indicate factors involved in the pathogenesis of ICAS-related stroke.
- Published
- 2016
46. Treating Pulsatile Exophthalmos in Child with Minimally Invasive Approach and Custom-made Titanium Mesh Plate
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Naoaki Iwamoto, Mutsumi Okazaki, Shuji Yamashita, Yuta Moriwaki, Hideaki Imai, Yoko Tomioka, Takuya Iida, and Koji Kanayama
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medicine.medical_specialty ,Exophthalmos ,business.industry ,medicine.medical_treatment ,lcsh:Surgery ,Pulsatile flow ,Brain Contusion ,Case Report ,lcsh:RD1-811 ,030230 surgery ,medicine.disease ,Cranioplasty ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Hematoma ,030220 oncology & carcinogenesis ,Coronal plane ,medicine ,Neurosurgery ,medicine.symptom ,business ,Complication - Abstract
Summary:. Orbital roof fracture is a relatively rare trauma. In most cases, surgical intervention is not needed since the fracture is slight. However, invasive surgical procedures are inevitable once pulsatile exophthalmos occurs if vision impairment is to be avoided. We report our rare experience of orbital roof fracture in a child with pulsatile exophthalmos. Good reconstruction of the anterior cranial base was achieved using a custom-made titanium mesh and a minimally invasive approach. A 3-year-old girl who had been diagnosed with subdural hematoma, brain contusion, and fracture of the right orbital roof caused by facial bruising underwent emergent external decompression by coronal skin incision and a transcranial approach on the same day as the trauma. Cranioplasty using autologous frozen bone in the same approach was performed 103 days posttrauma, but this was followed by pulsatile exophthalmos. After recovering from critical stage, the girl was brought to our department for reconstruction of the anterior base. Risk of vision impairment was also one reason for reconstruction, but the neurosurgeon hesitated to approach the region using a coronal approach considering the possibility of infection in the frozen autologous bone. Through cross-team discussion, reconstruction using a subeyebrow incision was performed with a custom-made titanium mesh plate. Pulsatile exophthalmos completely disappeared. Pulsatile exophthalmos is a very rare but serious complication that carries a risk of vision impairment. By applying a custom-made titanium mesh plate, precise reconstruction was enabled with minimal invasiveness and low risk.
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- 2019
47. Genetic Variant RNF213 c.14576G>A in Various Phenotypes of Intracranial Major Artery Stenosis/Occlusion
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Masahiro Shimizu, Akitake Mukasa, Shinichi Yagi, Hideaki Imai, Nobuhito Saito, Hideaki Ono, Satoru Miyawaki, Tsuneo Shimizu, and Hirofumi Nakatomi
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Male ,medicine.medical_specialty ,Ubiquitin-Protein Ligases ,Population ,Aneurysm ,Asian People ,Japan ,Risk Factors ,Internal medicine ,Occlusion ,medicine ,Humans ,Moyamoya disease ,education ,Alleles ,Adenosine Triphosphatases ,Advanced and Specialized Nursing ,Intracerebral hemorrhage ,education.field_of_study ,business.industry ,Incidence ,Case-control study ,Genetic Variation ,Odds ratio ,medicine.disease ,Surgery ,Stenosis ,Case-Control Studies ,Cardiology ,Female ,Neurology (clinical) ,Moyamoya Disease ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background and Purpose— Recently, we reported a common genetic variant, ring finger protein 213 ( RNF213 ) c.14576G>A variant, a susceptibility gene for moyamoya disease (MMD), among patients with intracranial major artery stenosis/occlusion (ICASO) in a selected Japanese population. The aim of this 2-center–based case–control study was to confirm our previous finding in a larger population. Methods— Study participants were recruited from The University of Tokyo Hospital and Kanto Neurosurgical Hospital. The occurrence rate of c.14576G>A variant was investigated in 323 patients, 22 with definite MMD, 8 with unilateral MMD, 84 with ICASO in the absence of MMD (non-MMD ICASO), 34 with extracranial carotid atherosclerosis, 44 with cerebral aneurysm, 21 with intracerebral hemorrhage, and 110 control subjects. Results— RNF213 c.14576G>A variant was found in 1.8% (2/110) of the normal control group and had significant associations with definite MMD ( P P =0.0001; odds ratio, 54.0; 95% confidence interval, 7.5–386.8), and non-MMD ICASO ( P Conclusions— A particular subset of patients with various phenotypes of ICASO has a common genetic variant, RNF213 c.14576G>A, indicating that RNF213 c.14576G>A variant is a high-risk allele for ICASO.
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- 2013
48. Virtual Reality Neurosurgical Simulation using Computer Graphics
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Masaaki Shojima, Hirofumi Nakatomi, Taichi Kin, Nobuhito Saito, Akitake Mukasa, Masanori Yoshino, Hideaki Imai, Daichi Nakagawa, Masahiro Shin, Hiroshi Oyama, and Shunya Hanakita
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Computer graphics ,business.industry ,Computer graphics (images) ,Medicine ,Surgery ,Neurology (clinical) ,Virtual reality ,business - Published
- 2013
49. Symptomatic Recurrence of Intracranial Arterial Dissections
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Akira Teraoka, Hirofumi Nakatomi, Takafumi Ide, Kazuo Tsutsumi, Nobuhito Saito, Hideaki Ono, Chifumi Kitanaka, Keisuke Ueki, Tomohiro Inoue, Hideaki Imai, and Yuhei Yoshimoto
- Subjects
Adult ,Male ,medicine.medical_specialty ,Subarachnoid hemorrhage ,Adolescent ,Infarction ,Cohort Studies ,Young Adult ,Aneurysm ,Secondary Prevention ,medicine ,Humans ,Young adult ,Child ,Pathological ,Aged ,Aged, 80 and over ,Advanced and Specialized Nursing ,Arterial dissection ,business.industry ,Intracranial Aneurysm ,Middle Aged ,medicine.disease ,Surgery ,Radiography ,Aortic Dissection ,Treatment Outcome ,Female ,Histopathology ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies ,Cohort study - Abstract
Background and Purpose— The frequency and pattern of symptomatic recurrence of spontaneous intracranial arterial dissection (IAD) are unknown. Methods— A follow-up study of 143 patients (85 men, 58 women; mean age, 50.7 [7–83] years) with spontaneous IADs at The University of Tokyo and affiliated hospitals from 1980 to 2000 was conducted. Tissue samples of IAD vessels obtained from 13 patients at various intervals from onset were also examined histologically. Results— With a mean follow-up of 8.2 years, symptomatic recurrence occurred in 47 patients (33%). Of 37 cases initially presenting with hemorrhage, 35 developed hemorrhagic recurrence with a mean interval of 4.8 days, and 2 developed nonhemorrhagic recurrences after 21 and 85 months, respectively. Of 10 patients initially presenting with nonhemorrhagic symptoms, 1 developed hemorrhagic recurrence 4 days later, and 9 developed nonhemorrhagic recurrences with a mean interval of 8.6 months. Histopathologically, the affected vessels in the acute stage of hemorrhage (days 0–6) demonstrated insufficient granulation formation within the pseudolumen, followed by marked intimal thickening around the pseudolumen and recanalizing vessel formation in the late stage (>day 30). In the late stage of brain ischemia, subintimal and subadventitial hemorrhage accompanied with intimal thickening was observed. Conclusions— These data indicate that IAD is a disease carrying a relatively high risk of symptomatic recurrence, apparently occurring in 3 phases and patterns: early hemorrhagic recurrence, late nonhemorrhagic recurrence, and chronic fusiform aneurysm transformation. Knowledge of this triphasic recurrence and corresponding histopathological characteristics help determine the treatment and follow-up strategy for IAD patients.
- Published
- 2013
50. Identification of a Genetic Variant Common to Moyamoya Disease and Intracranial Major Artery Stenosis/Occlusion
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Satoru Miyawaki, Akitake Mukasa, Hirofumi Nakatomi, Nobuhito Saito, Hideaki Imai, and Shunsaku Takayanagi
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Adult ,Male ,medicine.medical_specialty ,Ubiquitin-Protein Ligases ,Central nervous system disease ,Aneurysm ,Asian People ,Japan ,Risk Factors ,Internal medicine ,Occlusion ,medicine ,Humans ,Genetic Predisposition to Disease ,Moyamoya disease ,Stroke ,Aged ,Adenosine Triphosphatases ,Advanced and Specialized Nursing ,Vascular disease ,business.industry ,Genetic Variation ,Middle Aged ,medicine.disease ,Surgery ,Stenosis ,Case-Control Studies ,Cardiology ,Female ,Cerebral Arterial Diseases ,Neurology (clinical) ,Neurosurgery ,Moyamoya Disease ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background and Purpose— The c.14576G>A variant in ring finger protein 213 (RNF213) was recently identified as a susceptibility gene variant for moyamoya disease (MMD). The occurrence of c.14576G>A variant was evaluated in patients with intracranial major artery stenosis/occlusion (ICASO) without signs of MMD (non-MMD ICASO), as well as in patients with MMD and other cerebrovascular diseases as controls. Methods— This single-hospital–based case-control study was completed in 7 months (from October 2011–April 2012) at Department of Neurosurgery, The University of Tokyo Hospital. The occurrence of c.14576G>A variant was analyzed in 41 patients with non-MMD ICASO, in 48 with MMD, in 21 with cervical disease, in 61 with cerebral aneurysm, and in 25 normal subjects. Results— Nine of 41 patients (21.9%) with non-MMD ICASO and 41 of 48 (85.4%) with MMD had the c.14576G>A variant. One of 61 patients (1.6%) with cerebral aneurysm and no patients with cervical disease or normal subjects had the variant. Comparison of each phenotype group with the normal subjects showed that presence of c.14576G>A variant had significant associations with MMD (odds ratio [OR], 292.8; 95% confidence interval [CI], 15.4–5153.0; P Conclusions— The present study indicates that a particular subset of Japanese patients with non-MMD ICASO has a genetic variant associated with MMD. Therefore, we propose the existence of a new entity of ICASO caused by the c.14576G>A variant in RNF213.
- Published
- 2012
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