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Association Between the Onset Pattern of Adult Moyamoya Disease and Risk Factors for Stroke
- Source :
- Stroke. 51(10)
- Publication Year :
- 2020
-
Abstract
- Background and Purpose: Few previous studies have comprehensively explored the relationship between the onset pattern of adult moyamoya disease and risk factors for stroke. We performed a retrospective analysis focusing on risk factors for stroke and related findings on magnetic resonance imaging/angiography with respect to the pattern of disease onset. We also examined whether risk factors for stroke were associated with an increased risk for symptomization in asymptomatic patients. Methods: A total of 178 adult patients with moyamoya disease (asymptomatic, n=84; ischemic, n=71; hemorrhagic, n=23) at the University of Tokyo Hospital from 2000 to 2018 were included in this study. Data pertaining to patient background and magnetic resonance imaging findings were analyzed retrospectively. In the asymptomatic group, the effects of stroke-associated risk factors on symptom onset were analyzed. Results: Comparisons among the 3 groups revealed no significant difference in the frequency of risk factors for stroke. The proportion of patients with magnetic resonance imaging/angiography findings indicating anterior choroidal artery anastomosis or microbleeds was significantly higher in the hemorrhagic group than in the asymptomatic or ischemic group. Among asymptomatic patients, the hazard ratios for symptomization with hypertension and dyslipidemia were 6.69 ([95% CI, 1.23–36.4] P =0.028) and 8.14 ([95% CI, 1.46–45.2] P =0.017), respectively. Conclusions: The development of anterior choroidal artery anastomosis and microbleeds on magnetic resonance imaging/angiography was significantly associated with hemorrhagic onset. Hypertension and dyslipidemia may increase the risk of cerebrovascular events in asymptomatic patients, and thus, early intervention to these factors may be important.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
03 medical and health sciences
0302 clinical medicine
Risk Factors
0502 economics and business
medicine
Humans
Moyamoya disease
Stroke
Retrospective Studies
Advanced and Specialized Nursing
medicine.diagnostic_test
business.industry
05 social sciences
Brain
Magnetic resonance imaging
Cerebral Arteries
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Natural history
050211 marketing
Female
Neurology (clinical)
Moyamoya Disease
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Magnetic Resonance Angiography
Subjects
Details
- ISSN :
- 15244628
- Volume :
- 51
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.doi.dedup.....d63b869d159de1edd4b0feee6861abd8