99 results on '"Giant basal cell carcinoma"'
Search Results
2. Neglected Fungating Giant basal cell carcinoma: A case report and literature review
- Author
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Susmin Karki, Asmita Parajuli, Bhawesh Bhattarai, Khusbu Kumari, Kayleigh Anjali Harrylal, Pramish Bhatta, Milan K. C., and Samit Sharma
- Subjects
basal cell carcinoma ,BCC ,case report ,giant basal cell carcinoma ,Medicine ,Medicine (General) ,R5-920 - Abstract
Key Clinical Message Gaint fungating BCC is rare and aggressive. Early health‐seeking behavior may result in positive outcomes. Abstract Fungating giant basal cell carcinoma (BCC) is a rare and aggressive form of BCC infrequently reported in the literature. We present a giant BCC case in an old female from a rural area with a poor socioeconomic profile.
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- 2024
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3. Giant nodular basal cell skin cancer
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Tatiana G. Sedova and Vladimir D. Elkin
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case reports ,giant basal cell carcinoma ,nodular form ,clinic ,diagnostics ,prognosis ,Dermatology ,RL1-803 - Abstract
The article presents clinical case report of primary giant nodular basal cell skin cancer in two patients at the age of 64 and 68 years and with disease duration of 20 and 15 years respectively. Psychological status of fear and anxiety are considered the main reasons for the late health encounter. The clinical picture of the case report was characterized by a slow long-term asymptomatic growth of solitary tumor-like mushroom-shaped nodes of stagnant pink color with a bumpy surface, densely elastic consistency, adherent to underlying soft tissues and sized 9.5 7.0 cm and 5.0 9.0 cm respectively. Giant basaliomas were located on the scalp in a woman and on the trunk skin in a man. The clinical tumors features are corresponded to those of a large conglomerated basal cell skin cancer. The article also presents a description of the clinical and dermatoscopic picture of giant nodular basaliomas. The patients underwent curative surgical excision of tumors with pathomorphological examination of the postoperative material. The histological picture of giant basal cell carcinoma in both cases is represented by tumors of a complex structure, namely a solid adenoid type with invasion into the reticular dermis and subcutaneous fat. The low biological potential of giant nodular basaliomas has been established.
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- 2023
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4. A Case of Giant Basal Cell Carcinoma of the Ear Complicated by Primary Cutaneous Aspergillosis
- Author
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Yao Y, Li T, Huang Y, and Cheng H
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giant basal cell carcinoma ,primary ,cutaneous aspergillosis ,Dermatology ,RL1-803 - Abstract
Yabo Yao, Tianhao Li, Yuanen Huang, Hongbin Cheng Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of ChinaCorrespondence: Hongbin Cheng, Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39, Shi-er-qiao Road, Jinniu District, Chengdu, People’s Republic of China, Email chenghongbin@cdutcm.edu.cnAbstract: A 78-year-old female patient with right ear agenesis presented with a skin manifestation of approximately 7 cm × 8 cm deep-invasive ulcer with well-defined borders and a small amount of yellow purulent discharge visible at the base, surrounded by pearl-like margins in a dyke-like elevation, covered with a small amount of necrotic tissue and black crust. The disease lasted for more than 20 years and was diagnosed as giant basal cell carcinoma complicated by primary cutaneous aspergillosis after two histopathological examinations of the skin lesions. There are similarities in the clinical manifestations of these two diseases, which need to be differentiated, and the simultaneous complications are infrequent. It has not been reported.Keywords: giant basal cell carcinoma, primary, cutaneous aspergillosis
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- 2022
5. Management of patients with giant basal cell carcinoma during SARS COV2 outbreak in Italy.
- Author
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Cantisani, Carmen, Rossi, Raimondo, Nisticò, Steven Paul, Vitiello, Martina, Farnetani, Francesca, Bennaro, Luigi, and Pellacani, Giovanni
- Subjects
BASAL cell carcinoma ,SARS Epidemic, 2002-2003 ,SKIN cancer ,TREATMENT effectiveness ,PHOTODYNAMIC therapy - Abstract
Basal cell carcinoma (BCC) is the most frequently occurring type of all cancers, and represents 80% of all skin cancer. The estimated lifetime risk for BCC in the white population is between 33% and 39% for men and 23% and 28% for women. Its incidence doubles every 25 years and is increasing in the young population. Death is uncommon and seems to decrease in the last years, probably due to early and better diagnosis. BCC arises from abnormal and uncontrolled growth of basal cells. It is a slow‐growing tumor, therefore usually curable at an early stage with surgery or alternative treatment, such as cryotherapy, laser, photodynamic therapy, retinoids and topical agent like 5‐Fluorouracil cream, imiquimod cream, and so forth. Topical treatment of superficial basocellular carcinoma is a viable option, when surgery is not an advisable treatment, especially in the case of giant basocellular carcinoma. In this subtype, imiquimod 5% cream can be a safe and effective treatment, but there are few reports in available literature. We present our case series of eight patients with superficial giant basocellular carcinoma successfully treated with imiquimod 5% cream, which showed clinical improvement after 8 weeks of treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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6. Management of patients with giant basal cell carcinoma during SARS COV2 outbreak in Italy
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Carmen Cantisani, Raimondo Rossi, Steven Paul Nisticò, Martina Vitiello, Francesca Farnetani, Luigi Bennaro, and Giovanni Pellacani
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basal cell carcinoma ,giant basal cell carcinoma ,imiquimod ,immunomodulator agent ,superficial basal cell carcinoma ,topical therapy ,Applied optics. Photonics ,TA1501-1820 ,Medical technology ,R855-855.5 - Abstract
Abstract Basal cell carcinoma (BCC) is the most frequently occurring type of all cancers, and represents 80% of all skin cancer. The estimated lifetime risk for BCC in the white population is between 33% and 39% for men and 23% and 28% for women. Its incidence doubles every 25 years and is increasing in the young population. Death is uncommon and seems to decrease in the last years, probably due to early and better diagnosis. BCC arises from abnormal and uncontrolled growth of basal cells. It is a slow‐growing tumor, therefore usually curable at an early stage with surgery or alternative treatment, such as cryotherapy, laser, photodynamic therapy, retinoids and topical agent like 5‐Fluorouracil cream, imiquimod cream, and so forth. Topical treatment of superficial basocellular carcinoma is a viable option, when surgery is not an advisable treatment, especially in the case of giant basocellular carcinoma. In this subtype, imiquimod 5% cream can be a safe and effective treatment, but there are few reports in available literature. We present our case series of eight patients with superficial giant basocellular carcinoma successfully treated with imiquimod 5% cream, which showed clinical improvement after 8 weeks of treatment.
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- 2022
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7. A Rare Case of Neglected Giant Basal Cell Carcinoma in a Nurse-Case Report and Literature Review.
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COJOCARU, ANCA, ORZAN, OLGUȚA-ANCA, BÎRJOVANU, CARROL, ANDREEA, NICOLAE CĂTĂLINA, PETRACHE, DIANA, MARINESCU, ELENA-ALEXANDRA, and CIUREA, MARIUS-EUGEN
- Subjects
- *
BASAL cell carcinoma , *SKIN cancer , *LITERATURE reviews , *SQUAMOUS cell carcinoma , *NURSE-patient relationships , *CANCER patients - Abstract
Basal cell carcinoma (BCC) is the most common skin cancer in the fair-skinned adult population over 50 years of age and the incidence is rising. Generally, BCC has an indolent course, low mortality and a good prognosis due to low rates of metastasis. Giant basal cell carcinoma is a rare reported oncological entity which accounts for 0.5% to 1% of all cases of BCC and has a diameter larger than 5cm. Basosquamous carcinoma is a rare high-risk type of BCC with clinical and histopathological features of both BCC and squamous cell carcinoma. A 61-year-old female presented to our clinic for a giant bleeding tumor located under her left breast. She initially noted the tumor almost 15 years ago. Although the patient was a nurse, she was afraid to seek medical advice until an episode of significant bleeding. At presentation the tumor was a 15/7cm in size, was invading the underlying structures and had a central ulceration. The margins of the tumoral plaque had several nodules and pearly structures suggesting the possible clinical diagnosis of BCC. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Slow‐growing pedunculated nodule
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Chaima Kouki, Nadine Kammoun, Khadija Sellami, Emna Bahloul, Manel Mallouli, Lobna Ayadi, Tahya Boudaouara, and Hamida Turki
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giant basal cell carcinoma ,pedenculated basal cell carcinoma ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract There have been limited reported cases of pedunculated basal cell carcinoma(BCC). Our case is original, and it combines two rare aspects of CBC: Pedunculated and giant. This uncommon aspect is rarely encountered.
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- 2022
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9. Giant basal cell carcinoma in a non-sun exposed area with four years follow-up: a case report.
- Author
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Alhetheli G
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- Humans, Female, Follow-Up Studies, Biopsy, Quality of Life, Aged, Diagnostic Errors, Carcinoma, Basal Cell pathology, Carcinoma, Basal Cell diagnosis, Skin Neoplasms pathology, Skin Neoplasms diagnosis
- Abstract
Basal cell carcinoma (BCC) is a low-grade malignant tumor that if properly managed has an excellent prognosis. Development of BCC outside the skin areas exposed to sun rays is infrequent. Giant BCC is a rare entity, especially in unexposed areas of the body. It carries a considerable implication on patients' quality of life because of the risk of being a source of infection that may progress to severe sepsis and/or metastasis. An old female presented with a long-standing solitary lesion measuring 7.5x6 cm overlaying the lumber 4-5 vertebral region about 2.5 cm from the line of the sacral promontory. No lymph nodes or distant metastases were detected. For many years, it was misdiagnosed by other physicians as eczema, psoriasis, and fungal infection and accordingly failed to respond to treatment. A histopathological examination of lesional punch biopsy assured the diagnosis of giant superficially spreading BCC. The lesion was excised with a circumferential safety margin of about 5 mm. During the follow-up period of 4 years, no recurrence was detected. Despite being a long-standing Giant basal cell carcinoma (GBCC) in a sun-hidden skin area, the growth behaved as a locally malignant lesion without metastasizing. A wide local surgical excision of the GBCC with 5 mm safety margins was feasible, safe, and with a good aesthetic outcome. Importantly, family practitioners should avoid such missed cases through accuracy in their diagnosis and early referral of any atypical cases to a dermatologist., Competing Interests: The author declares no competing interests., (Copyright: Ghadah Alhetheli et al.)
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- 2024
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10. A large hyperplastic nodule on the abdomen
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Zhang, Yanfei, Li, Zhengxiao, Xiao, Shengxiang, and Feng, Yiguo
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Basal cell carcinomas ,Giant basal cell carcinoma ,Dermatopathology ,hyperplastic cutaneous nodule - Abstract
A 65-year-old man presented with a slowly enlarging, hyperplastic cutaneous nodule on the abdomen that developed over a period of 20 years. Based on the clinical manifestation and typical histopathology, the patient received a diagnosis of giant basal cell carcinoma.
- Published
- 2015
11. Giant basal cell carcinoma associated with vitiligo
- Author
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Luiza Fiszon‐Cerqueira, Marcia Ramos‐e‐Silva, Flávio Bacelar Guerreiro, Marcela Cistaro‐Serrano, Ana Helena Correia Carneiro, and Maria Kátia Gomes
- Subjects
basal cell carcinoma ,giant basal cell carcinoma ,squamous cell carcinoma ,vitiligo ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract We report a woman with two giant Basal cell carcinomas (BCCs) on the back, the largest with 12 cm in diameter, inside a vitiligo plaque. They were metatypical subtype BCC associated with a nodular subtype area. Thinking of BCC in vitiligo lesion is extremely important. Giant BCC and vitiligo are rare association.
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- 2019
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12. Carcinoma basocelular gigante en un paciente con esquizofrenia no controlada.
- Author
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Serrano-Ríos, Fray Elaev and Rodríguez-Mena, Adriana del Carmen
- Abstract
BACKGROUND: Skin cancer is one of the most frequent malignant neoplasms worldwide; in this group the basal cell carcinoma is the most common; nevertheless, different clinical variants exist that modify the natural evolution of the disease. CLINICAL CASE: A 50-year-old male patient with history of uncontrolled schizophrenia in who a giant basal cell carcinoma was found, but, in spite of its size and evolution, no invasion to deep tissue was found. CONCLUSIONS: Giant basal cell carcinoma is a rare and aggressive subtype of basal cell carcinoma and, therefore, requires multidisciplinary management, with some difficulties in choosing the appropriate treatment. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Conventional versus giant basal cell carcinoma, a review of 57 Cases: Histologic differences contributing to excessive growth
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J Chase Purnell, Jerad M Gardner, J Ahmad Brown, and Sara C Shalin
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Basal cell carcinoma ,giant basal cell carcinoma ,host immune response ,plasma cells ,Dermatology ,RL1-803 - Abstract
Background: Giant basal cell carcinoma (GBCC) is defined as a basal cell carcinoma (BCC) exceeding 5 cm in size. While these tumors impart significant morbidity due to local tissue destruction and have a higher rate of metastatic disease than their conventional (smaller) counterparts, reasons for their large size remain unclear. While theories relating to neglect or faster growth rate are often invoked; to date, there has not been a comprehensive evaluation of the histologic features of these large tumors that may contribute to their size. Methods: Histologic features of GBCCs (n = 29) were evaluated and compared to those of conventional BCC (n = 28). Available clinical demographic data were also reviewed. Results: GBCCs, in addition to overall larger size, more often were thicker, displayed ulceration, and showed a more infiltrative growth pattern than their conventional counterparts. These rare tumors also displayed an insignificant increased propensity for a brisk host immune response, and the infiltrate significantly more often included clusters of plasma cells. Conclusions: Most histologic features seen in GBCCs likely reflect their large size. Histologic features alone are unlikely to explain the size of these rare tumors. The possibility of an altered host immune response contributing to the growth of these tumors requires further investigation.
- Published
- 2018
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14. Reappraisal of giant basal cell carcinoma: Clinical features and outcomes.
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Oudit, Deemesh, Pham, Hoang, Grecu, Titus, Hodgson, Clare, Grant, Megan E., Rashed, Andzhela Abu, Allan, Donald, and Green, Adele C.
- Abstract
Giant basal cell carcinoma (GBCC) is a rare subgroup of basal cell carcinomas with a diameter of >5 cm. Current evidence about determining factors is conflicting, suggesting patient neglect, on the one hand, and biologically aggressive behaviour, on the other, with outcomes varying from clearance to death. We aimed to clarify the natural history of GBCC and its response to treatment. We extracted information from clinical records of all patients with GBCC treated from 1998 to 2017 in a tertiary oncology hospital in northwest England. Associations between patient and tumour characteristics were investigated, and modes of treatment and outcomes were assessed. In the 20-year study period, 43 patients (median age 76 years; 23 (53%) female), 3 of whom had Gorlin syndrome, were treated for GBCCs. Median diameter was 6.3 cm, and median time to presentation was 5 years. Seven (16%) GBCCs arose from recurrent BCC, while the majority (84%) presented de novo. The size of GBCC was significantly correlated with delay in presentation (p = 0.03) but not with age or sex. Of 41 patients receiving definitive treatment, 19 GBCCs were treated by excision with ≤1 cm margin and none recurred during follow-up, compared with 10 recurrences of 23 treated with photodynamic therapy (PDT), and 1 of 7 recurred after radiotherapy. Two of 43 patients with GBCC (<5%) presented with extensive local invasion, one of whom also had distant metastases, and both died of the disease. The majority of GBCCs are not clinically aggressive and respond to conservative surgical treatment with a low risk of recurrence. [ABSTRACT FROM AUTHOR]
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- 2020
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15. Giant Basal Cell Carcinomas Arising on the Bilateral Forearms of a Patient: A Case Report and Review of Nonsurgical Treatment Options
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Sarah Shangraw, Rivka C. Stone, Jeong Hee Cho-Vega, and Robert S. Kirsner
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Medical therapy ,Giant basal cell carcinoma ,Nonsurgical treatment ,Dermatology ,RL1-803 - Abstract
Giant basal cell carcinomas (GBCCs) are large basal cell carcinomas (BCCs;
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- 2016
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16. Versatility of the O-Z flap for back reconstruction after giant basal cell carcinoma resection: A case report and review of the literature.
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Torresetti, Matteo, Gioacchini, Matteo, Scalise, Alessandro, and Di Benedetto, Giovanni
- Abstract
• Giant basal cell carcinomas are rare and potentially aggressive tumors. • Aggressive surgical resection with suggested wide free margins is suggested. • Soft tissue reconstruction for back lesions may be challenging. • The O-Z flap represents a safe and reliable alternative for back reconstruction. Giant basal cell carcinomas are rare and potentially aggressive skin malignancies that are infrequently reported in the Literature, and they usually require aggressive surgical resection and immediate soft tissue reconstruction with skin grafts or flaps. The large size of GBCCs has relevant implications not only for the metastatic potential, but even for the reconstructive challenging due to the possible limited availability of tissues for flap coverage. We report the peculiar case of an old patient who underwent to GBCC resection of the back measuring 16 × 13 cm, and immediate reconstruction with a large O to Z flap harvested from the back; one-year follow-up examination revealed a satisfactory result and no recurrence of the disease was observed. The review of the Literature showed that reconstructive options are mainly determined by the site and extent of the defect, exposed structures and patient characteristics and comorbidities, and previous series reported the use of skin grafts only, pedicled myocutaneous or perforator flaps, exclusively free flaps and a combination of techniques. Therefore, in this scenario local flaps such as O-Z flaps are less invasive procedures, that usually have lower rate of postoperative complications and shorter hospitalization compared to more complex procedures. Despite the use of O-Z flap is quite unusual for back reconstruction, we believe that this flap represents a valid and safe alternative in selected cases, particularly in the elderly and medically compromised patients with multiple comorbidities. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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17. Giant basal cell carcinoma associated with vitiligo.
- Author
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Fiszon‐Cerqueira, Luiza, Ramos‐e‐Silva, Marcia, Guerreiro, Flávio Bacelar, Cistaro‐Serrano, Marcela, Carneiro, Ana Helena Correia, and Gomes, Maria Kátia
- Subjects
- *
BASAL cell carcinoma , *VITILIGO , *SQUAMOUS cell carcinoma - Abstract
We report a woman with two giant Basal cell carcinomas (BCCs) on the back, the largest with 12 cm in diameter, inside a vitiligo plaque. They were metatypical subtype BCC associated with a nodular subtype area. Thinking of BCC in vitiligo lesion is extremely important. Giant BCC and vitiligo are rare association. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
18. Giant Basal Cell Carcinoma of the Lumbosacral Region: A Case Report and Literature Review
- Author
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Arzu Akçal, Selami Serhat Şirvan, Kamuran Zeynep Sevim, Semra Hacıkerim Karşıdağ, and Kemal Uğurlu
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Skin cancer ,giant basal cell carcinoma ,Medicine ,Surgery ,RD1-811 - Abstract
Objective: Although frequently regarded as a low grade malignancy, basal cell carcinoma (BCC) sometimes shows aggressive behavior. Giant BCC is defined as a lesion greater then 5 centimeter. Material and Methods: The authors described the diagnosis and treatment protocol of giant BCC, involving lumbosacral region without any local or distant metastasis. Also the authors went through a thorough a retrospective literature research of giant BCCs in terms of frequency and treatment. Results: Giant BCCs are biologically more aggressive; however, patient’s negligence is a key factor for the tumor size. İnternational medical database (PubMed) search reveals 253 giant BCCs with the most commonly seen site as the face and back area. However perianal BCCs are seen lower then 1%. Conclusion: In general, diagnosed giant BCCs account for lower then 1% of all BCCs. One must keep in mind this diagnosis to discard the metastasis rate among BCCs.
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- 2016
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19. Necrotic Chest Wall Mass: Atypical Presentation of Giant Basal Cell Carcinoma.
- Author
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Newman, Ashley, Ventarola, Daniel, and To, Jennifer
- Subjects
- *
BASAL cell carcinoma , *EPIDERMAL growth factor receptors - Abstract
The article describes the case of a 73-year-old male with giant basal cell carcinoma (GBCC). The patient arrived in the emergency department with a large bleeding ulcerated lesion of his right anterior chest wall and was in hemorrhagic and septic shock. His computed tomography of the chest revealed a subcutaneous defect with emphysema along the right axilla, sternal fracture and possible osteomyelitis. His treatment is primarily focused on excision and reconstruction.
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- 2020
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20. Giant Basal Cell Carcinoma of the Lateral Neck: A Case Study.
- Author
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Bryson AM, Dominiak N, and Frank PW
- Abstract
A giant basal cell carcinoma (GBCC) is a rare variant of basal cell carcinoma (BCC) that is larger (>5 cm) and more aggressive. While BCC is usually surgically excised as a small, local tumor, cases of GBCC represent a considerable portion of BCC malignancies and mortality. The growth of GBCC is hypothesized to be multifactorial, and due to the successful treatment of BCC, available data is limited. We present a case of GBCC found during routine post-mortem dissection in a 92-year-old male cadaver. The neoplasm showed predilection to periauricular soft tissue invasion, despite demonstrating high-risk characteristics for metastasis. Microscopic analysis demonstrated an infiltrative growth pattern and neurotropism. Perineural spread could be observed on gross dissection, indicating a worse prognosis, but there was no evidence of lymphatic or hematogenous spread. This is most likely due to the stromal dependence of BCC. Local invasion of the primary tumor likely compromised head and neck function, but there was no secondary tumor evidence. There were no histopathological findings that indicate an aggressive growth or metastatic transformation of the tumor. Therefore, while a conclusion about duration cannot be made due to the anonymity of the cadaver, duration of growth likely was a significant factor in mortality., Competing Interests: The authors have declared financial relationships, which are detailed in the next section., (Copyright © 2023, Bryson et al.)
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- 2023
- Full Text
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21. Conventional Versus Giant Basal Cell Carcinoma, a Review of 57 Cases: Histologic Differences Contributing to Excessive Growth.
- Author
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Purnell, J, Gardner, Jerad, Brown, J, and Shalin, Sara
- Subjects
- *
DISEASE risk factors , *BASAL cell carcinoma , *COMPARATIVE studies , *GIANT cell tumors , *HISTOLOGY , *METASTASIS , *PLASMACYTOMA ,IMMUNE system physiology - Abstract
Background: Giant basal cell carcinoma (GBCC) is defined as a basal cell carcinoma (BCC) exceeding 5 cm in size. While these tumors impart significant morbidity due to local tissue destruction and have a higher rate of metastatic disease than their conventional (smaller) counterparts, reasons for their large size remain unclear. While theories relating to neglect or faster growth rate are often invoked; to date, there has not been a comprehensive evaluation of the histologic features of these large tumors that may contribute to their size. Methods: Histologic features of GBCCs (n = 29) were evaluated and compared to those of conventional BCC (n = 28). Available clinical demographic data were also reviewed. Results: GBCCs, in addition to overall larger size, more often were thicker, displayed ulceration, and showed a more infiltrative growth pattern than their conventional counterparts. These rare tumors also displayed an insignificant increased propensity for a brisk host immune response, and the infiltrate significantly more often included clusters of plasma cells. Conclusions: Most histologic features seen in GBCCs likely reflect their large size. Histologic features alone are unlikely to explain the size of these rare tumors. The possibility of an altered host immune response contributing to the growth of these tumors requires further investigation. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
22. Colgajo de rotación para carcinoma basocelular gigante en región craneal.
- Author
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C., Gallegos-Sierra, U., Flores-Hernández, E. A., Morales-Flores, J. E., Velázquez-Flores, and J. L., Villarreal-Salgado
- Abstract
Skin cancer is the most reported malignancy in the world; its most common variant is basal cell carcinoma with a relatively benign behavior; however, giant basal cell carcinoma is a rare variant that is characterized by aggressive biological behavior with deep tissue invasion and increased metastatic capacity. The giant basal cell carcinoma is defined as greater than 5 cm in diameter, it is an infrequent variant (<1%) and its importance lies in its potential recurrence after extirpation (38%). We present the case of a 72-year-old Caucasian patient with the purpose of establishing the therapeutic options that adapt to the therapeutic resources of each institution. The follow-up sequence is presented, corroborating patient evolution, currently at 2 years free of disease. [ABSTRACT FROM AUTHOR]
- Published
- 2018
23. Giant adenoid basal cell carcinoma of the scalp with intracranial involvement-successful management strategies for a rare entity.
- Author
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Ascha, Mona, Hiuser, Amy, Piliang, Melissa, and Schwarz, Graham
- Subjects
- *
BASAL cell carcinoma , *SCALP , *CANCER - Abstract
Adenoid basal cell carcinoma (BCC) is a rare but aggressive histologic subtype of BCC. The aim of this report is to present our multidisciplinary management strategy and a literature review on this seldom reported entity. A 72-year-old female with fungating giant BCC of the scalp, ear, and bone underwent preoperative biopsy revealing adenoid histology with infiltrating and nodular components. The patient underwent radical resection of the biparietal and occipital scalp, auriculectomy and craniectomy with dural resection. Immediate reconstruction of the intracranial and bony defect was performed with dural substitute and a titanium cranioplasty. The soft tissue defect was reconstructed with a latissimus dorsi free flap and split thickness skin graft using the right superficial temporal artery and vein as recipient vessels. Adjuvant external beam radiation was initiated postoperatively. Nearly 2 years postoperatively, she presented mesh exposure necessitating secondary reconstruction with debridement, hardware removal, and an anterolateral thigh (ALT) free flap, followed by flap debulking. Four years following initial presentation, she remains disease-free. To our knowledge, this is the only reported case of a giant, locally invasive scalp BCC with the adenoid subtype treated with composite resection and single stage reconstruction. Using an aggressive multimodal management paradigm, treatment and surveillance of the rarely reported, giant, locally invasive scalp BCC with adenoid subtype can result in a durable disease-free response and a functional, esthetic reconstruction. Evidence-based medicine level. Level of Evidence: Level V, therapeutic study. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
24. Successful treatment of giant basal cell carcinoma with topical imiquimod 5% cream with long term follow-up
- Author
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M Chun-Guang, L Qi-Man, Z H Yu-Yun, C H Li-Hua, Tiffany Cheng, and H Jian-De
- Subjects
Giant basal cell carcinoma ,Imiquimod ,treatment ,Dermatology ,RL1-803 - Abstract
The use of the topical Imiquimod 5% cream offers a noninvasive, nonsurgical, and an effective option for the treatment of primary small (5 cm) BCC with topical Imiquimod 5% cream are rare. We present our experience in the treatment of two giant tumors (6 × 8 cm 2 , 5.2 × 4.2 cm 2 ) of BCC on the face with Imiquimod 5% cream, 2 to 3 days/week for 12 weeks. Both the tumors were cured with clinical and pathological evidence, one with 6-year follow-up and the other with 3.5-year follow-up.
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- 2014
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25. Giant basal cell carcinoma of the face
- Author
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Mohammad Bayat, Amir Jalal Abbasi, Ata Garajei, and Naeem Ahmadi
- Subjects
Giant Basal Cell Carcinoma ,Modern Dressing ,Gel Dressing ,Silver Dressing ,Safe Margin ,Medicine - Abstract
This case report describes a 59-year-old woman with a giant basal cell carcinoma on the face neglected for 11 years. Surgical resection of the lesion resulted in a 13 × 11 cm defect. Issues regarding the adequately safe surgical margins and the management of the resultant defect through modern wound dressing technologies are discussed.
- Published
- 2016
26. Metastatic giant basal cell carcinoma: a case report
- Author
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Bellahammou Khadija, Lakhdissi Asmaa, Akkar Othman, Rais Fadoua, Benhmidou Nawal, Elghissassi Ibrahim, M'rabti Hind, and Errihani Hassan
- Subjects
giant basal cell carcinoma ,metastasis ,prognosis ,Medicine - Abstract
Basal cell carcinoma is the most common skin cancer, characterised by a slow growing behavior, metastasis are extremely rare, and it occurs in less than 0, 1% of all cases.Giant basal cell carcinoma is a rare form of basal cell carcinoma, more aggressive and defined as a tumor measuring more than 5 cm at its largest diameter. Only 1% of all basal cell carcinoma develops to a giant basal cell carcinoma,resulting ofpatient's negligence. Giant basal cell carcinoma is associated with higher potential of metastasis and even death, compared to ordinary basal cell carcinoma.We report a case of giant basal cell carcinoma metastaticin lung occurringin a 79 years old male patient, with a fatal evolution after one course of systemic chemotherapy.Giant basal cell carcinoma is a very rare entity, early detection of these tumors could prevent metastasis occurrence and improve the prognosis of this malignancy.
- Published
- 2016
- Full Text
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27. Complex reconstruction of the orbitofrontal regions using three regional flaps after orbital exenteration for the treatment of basal cell carcinoma
- Author
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Catalin Gheorghe Bejinariu, S Marinescu, and Christiana Diana Maria Dragosloveanu
- Subjects
Male ,medicine.medical_specialty ,Skin Neoplasms ,Orbital exenteration ,Case Reports ,Ophthalmologic Surgical Procedures ,Temporal muscle ,Surgical Flaps ,Postoperative results ,Humans ,Medicine ,Basal cell carcinoma ,giant basal cell carcinoma ,facial reconstruction ,Stage (cooking) ,orbital exenteration ,Orbit Evisceration ,Aged ,Retrospective Studies ,Surgical team ,business.industry ,Soft tissue ,General Medicine ,Plastic Surgery Procedures ,medicine.disease ,Facial reconstruction ,Carcinoma, Basal Cell ,Orbital Neoplasms ,Radiology ,Facial Neoplasms ,Tomography, X-Ray Computed ,business - Abstract
Objective. The current paper presents an interesting case of facial reconstruction after the excision of a giant basal cell carcinoma located in the orbitofrontal region. Methods. Performing the excision while securing the appropriate oncologic safety margin has determined the appearance of a soft tissue defect that required a complex reconstruction using three regional flaps: frontal, temporal fascial and temporal muscle flaps. Results. After the excision and reconstruction in a single surgical stage, the postoperative result was favorable, the 12 months assessment showing that the patient was satisfied with the aesthetic aspect. Conclusion. Including the orbital exenterations in the excisional treatment of giant neoplasms located in the facial region requires a complex reconstructive plan. The surgical team has to consider the relief of the anatomical structures that are targeted, as well as the necessity of achieving satisfactory aesthetic results while ensuring oncological radicality.
- Published
- 2020
28. Slow‐growing pedunculated nodule.
- Author
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Kouki, Chaima, Kammoun, Nadine, Sellami, Khadija, Bahloul, Emna, Mallouli, Manel, Ayadi, Lobna, Boudaouara, Tahya, and Turki, Hamida
- Subjects
- *
BASAL cell carcinoma - Abstract
There have been limited reported cases of pedunculated basal cell carcinoma(BCC). Our case is original, and it combines two rare aspects of CBC: Pedunculated and giant. This uncommon aspect is rarely encountered. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
29. Lumbosakral Alanda Dev Bazal Hücreli Karsinom: Olgu Sunumu ve Literatür Taraması.
- Author
-
Akçal, Arzu, Şirvan, Selami Serhat, Sevim, Kamuran Zeynep, Karşıdağ, Semra Hacıkerim, and Uğurlu, Kemal
- Abstract
Objective: Although frequently regarded as a low grade malignancy, basal cell carcinoma (BCC) sometimes shows aggressive behavior. Giant BCC is defined as a lesion greater then 5 centimeter. Material and Methods: The authors described the diagnosis and treatment protocol of giant BCC, involving lumbosacral region without any local or distant metastasis. Also the authors went through a thorough a retrospective literature research of giant BCCs in terms of frequency and treatment. Results: Giant BCCs are biologically more aggressive; however, patient's negligence is a key factor for the tumor size. İnternational medical database (PubMed) search reveals 253 giant BCCs with the most commonly seen site as the face and back area. However perianal BCCs are seen lower then 1%. Conclusion: In general, diagnosed giant BCCs account for lower then 1% of all BCCs. One must keep in mind this diagnosis to discard the metastasis rate among BCCs. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
30. Giant Basal Cell Carcinomas Arising on the Bilateral Forearms of a Patient: A Case Report and Review of Nonsurgical Treatment Options.
- Author
-
Shangraw, Sarah, Stone, Rivka C., Cho-Vega, Jeong Hee, and Kirsner, Robert S.
- Subjects
- *
BASAL cell carcinoma treatment , *METASTASIS , *HERBAL medicine , *CANCER radiotherapy , *CAUCASIAN race , *HEALTH - Abstract
Giant basal cell carcinomas (GBCCs) are large basal cell carcinomas (BCCs; <5 cm) with a greater propensity to invade and metastasize than standard BCCs. The presence of 2 GBCCs in a single individual is rare. We present the case of a 71-year-old Caucasian male with bilateral GBCCs on the dorsal forearms, measuring 130 cm² and 24 cm², respectively, that developed over a 21-year period. Over this period, the patient treated the tumors with herbal remedies. Histologic evaluation showed a conventional nodular BCC for both tumors. Computed tomography and magnetic resonance imaging revealed a T4N0M0 stage for the larger lesion. Surgical excision and grafting and reconstruction were offered, but he declined. This case highlights a shared belief in holistic treatments and rejection of Western medical inter-ventions that are common among many patients with GBCC. Studies reporting nonsurgical treatments for GBCCs, including radiotherapy, vismodegib, topical imiquimod, and acitretin are reviewed. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
31. Axial flap for giant basal cell carcinoma of the anterior chest wall: Case report
- Author
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Monica Bellynda, Affandi Wiramur, Kristanto Yuli Yarso, and Andhika Aji Nugroho
- Subjects
medicine.medical_specialty ,business.industry ,Anterior chest wall ,Case Report ,Anterior chest wall mass ,Skin tone ,Case presentation ,Axial flap ,medicine.disease ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Male patient ,Giant basal cell carcinoma ,030220 oncology & carcinogenesis ,Skin laxity ,Medicine ,030211 gastroenterology & hepatology ,Basal cell carcinoma ,Upper chest wall ,business ,Wide resection - Abstract
Introduction and importance Anterior chest wall Giant Basal Cell Carcinoma (GBCC) is rare amongst GBCC cases and results in a large defect that is challenging to resect and reconstruct. It requires multidisciplinary approach to prevent recurrence. Case presentation A 72-year-old man with giant basal cell carcinoma at the anterior chest wall measuring 10 × 6 cm. Wide resection of 1 cm margin with axial flap was performed to close the defect. The follow-up report stated that the patient was satisfied with the result and there was no recurrence observed. Clinical discussion Review of literatures concludes that GBCC is excised with a minimum of 4-6 mm margin outside the tumor area. The axial IMAP flap is ideal to close the upper chest wall defect because of the better aesthetic outcome compared to other conventional flaps, especially in stable elderly male, patients with noninfected wound. Increased skin laxity and more relaxed skin tension associated with aging allows easier tissue mobilization and transfer to close the defect. Conclusion Axial flap for GBCC in anterior chest wall is ideal, safe, and has the advantage of aesthetic reasons of suitable skin tone, particularly for stable elderly male patients., Highlights • A 72-year-old man presented with a seven-year history of ulcerating mass on his anterior chest wall. • Histopathologic examination confirmed the diagnosis of giant basal cell carcinoma (GBCC). • We performed wide resection with 1 cm margin and reconstruct the defect with axial flap. • No evidence of recurrence observed after 1 year of resection.
- Published
- 2021
32. Giant basal cell carcinoma associated with vitiligo
- Author
-
Flávio Bacelar Guerreiro, Maria Kátia Gomes, Ana Helena Pereira Correia Carneiro, Luiza Fiszon‐Cerqueira, Marcela Cistaro‐Serrano, and Marcia Ramos-e-Silva
- Subjects
squamous cell carcinoma ,vitiligo ,Pathology ,medicine.medical_specialty ,animal structures ,lcsh:Medicine ,Case Report ,Case Reports ,Vitiligo ,030204 cardiovascular system & hematology ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,basal cell carcinoma ,medicine ,Basal cell carcinoma ,Basal cell ,giant basal cell carcinoma ,skin and connective tissue diseases ,neoplasms ,lcsh:R5-920 ,integumentary system ,business.industry ,lcsh:R ,fungi ,General Medicine ,medicine.disease ,030220 oncology & carcinogenesis ,medicine.symptom ,lcsh:Medicine (General) ,business - Abstract
We report a woman with two giant Basal cell carcinomas (BCCs) on the back, the largest with 12 cm in diameter, inside a vitiligo plaque. They were metatypical subtype BCC associated with a nodular subtype area. Thinking of BCC in vitiligo lesion is extremely important. Giant BCC and vitiligo are rare association.
- Published
- 2019
33. Successful Treatment of Giant Basal Cell Carcinoma with Topical Imiquimod 5% Cream with Long Term Follow-up.
- Author
-
Chun-Guang M., Qi-Man L., Yu-Yun Z. H., Li-Hua C.H., Cheng, Tiffany, and Jian-De H.
- Subjects
- *
OINTMENTS , *HISTOLOGY methodology , *PATIENT aftercare , *BASAL cell carcinoma , *DRUG therapy , *HEALTH outcome assessment , *TIME , *TREATMENT effectiveness , *ARRHYTHMOGENIC right ventricular dysplasia , *THERAPEUTICS - Abstract
The use of the topical Imiquimod 5% cream offers a noninvasive, nonsurgical, and an effective option for the treatment of primary small (<2 cm) superficial basal cell carcinoma (sBCC). However, reports about successful treatment of giant (>5 cm) BCC with topical Imiquimod 5% cream are rare. We present our experience in the treatment of two giant tumors (6 × 8 cm2, 5.2 × 4.2 cm2) of BCC on the face with Imiquimod 5% cream, 2 to 3 days/week for 12 weeks. Both the tumors were cured with clinical and pathological evidence, one with 6-year follow-up and the other with 3.5-year follow-up. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
34. Giant Ulcerative Basal Cell Carcinoma with Local Metastasis: A Case Report and Assessment of Surgical Techniques
- Author
-
Jaafar Sahned, Dereen Mohammed Saeed, Darshan Thakkar, and Subhasis Misra
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Sentinel lymph node ,Dermatology ,030204 cardiovascular system & hematology ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,basal cell carcinoma ,Biopsy ,medicine ,Basal cell carcinoma ,giant basal cell carcinoma ,medicine.diagnostic_test ,skin cancer ,business.industry ,Incidence (epidemiology) ,Wide local excision ,General Engineering ,medicine.disease ,Oncology ,General Surgery ,Radiology ,Lymph ,Skin cancer ,business ,030217 neurology & neurosurgery - Abstract
Giant basal cell carcinoma (GBCC) is a rare skin cancer characterized by an aggressive biological behavior with extensive local invasion, frequent metastasis, and associated poor prognosis. Wide local excision with sentinel lymph node biopsy is often warranted for this condition, and reconstruction by local rotational flap is one of the best surgical techniques for repairing similar skin cancers with a relatively large skin defect. A 59-year-old man who was a former construction worker with a significant smoking history presented with a single giant suspicious chronic ulcerating skin lesion measuring 9 x 7 cm that proved to be a basal cell carcinoma (BCC) on his left shoulder. The patient was negative for enlarged or palpable lymph nodes and underwent a wide local excision and primary repair with a local flap. Despite negative margins, his follow-up visits at six, nine, and 10 months revealed numerous suspicious lesions that further required multiple local wide excisions that showed new basal cell carcinoma and recurrence to the left axilla. Given the invasiveness of his skin cancer, he was referred to oncology and later treated by chemoradiation. Patients with multiple risk factors are associated with a higher incidence of more invasive skin cancer due to possible cumulative effects. The therapeutic approach for GBCC should involve multidisciplinary teams, with wide local resection of the tumor with possible sentinel lymph node biopsy, local rotational flap for reconstruction of the wide defect, and adjuvant chemoradiotherapy if necessary.
- Published
- 2019
35. A Rare Case of Giant Basal Cell Carcinoma of the Abdominal Wall: Excision and Immediate Reconstruction with a Pedicled Deep Inferior Epigastric Artery Perforator (DIEP) Flap
- Author
-
Roberto Pirrello, Bartolo Corradino, Massimiliano Tripoli, Giovanni Zabbia, Adriana Cordova, Sara Di Lorenzo, Di Lorenzo, S., Zabbia, G., Corradino, B., Tripoli, M., Pirrello, R., and Cordova, A.
- Subjects
medicine.medical_specialty ,Skin Neoplasms ,Propeller Flap ,Settore MED/19 - Chirurgia Plastica ,030204 cardiovascular system & hematology ,Abdominal wall ,03 medical and health sciences ,Rare Diseases ,0302 clinical medicine ,DIEP flap ,Rare case ,medicine ,Carcinoma ,Humans ,Neoplasm Invasiveness ,Basal cell carcinoma ,giant basal cell carcinoma ,Aged, 80 and over ,Systemic complication ,business.industry ,Abdominal Wall ,Deep Inferior Epigastric Artery ,Articles ,General Medicine ,medicine.disease ,Multiple pathologies ,Surgery ,medicine.anatomical_structure ,Carcinoma, Basal Cell ,Female ,business ,Perforator Flap ,Basal Cell Carcinoma ,030217 neurology & neurosurgery - Abstract
Patient: Female, 82 Final Diagnosis: Giant basal cell carcinoma Symptoms: Anemia Medication: — Clinical Procedure: — Specialty: Plastic Surgery Objective: Rare disease Background: Basal cell carcinoma (BCC) greater than 5 cm in diameter is called giant basal cell carcinoma (GBCC), or super giant basal cell carcinoma if it has a diameter larger than 20 cm. Giant BCC only accounts for 0.5% of BCCs and super giant BCC is exceedingly rare. On account of their rarity, there are no established guidelines for GBCC treatment. Case Report: We describe a peculiar case of an 82-year-old woman with a GBCC carcinoma of the lower abdominal wall. The tumor was surgically removed with ipsilateral inguinal lymph nodes and the abdominal wall was reconstructed immediately with a pedicled deep inferior epigastric artery perforator (DIEP) flap. Conclusions: Treatment of giant basal cell carcinoma is often difficult, especially in elderly patients with poor general health and multiple pathologies. The pedicled DIEP flap is rotated to cover the loss of substance without tension, and it is easy to harvest and transfer. This flap allowed a good result without local or systemic complication. We present this report as a reminder of the occasional occurrence of extremely aggressive BCCs. We believe that, especially for rare tumors like these, it is very useful for the entire scientific community to publish these cases and the therapeutic strategies used to treat them.
- Published
- 2017
36. Carcinoma basocelular gigante: comunicación de un caso extraordinariamente agresivo en un paciente con síndrome mielodisplásico y mieloproliferativo.
- Author
-
Díaz González, José Manuel, Jasso Olivares, Julio César, Iglesias Morales, Martín, and Domínguez Cherit, Judith
- Subjects
- *
BASAL cell carcinoma , *MYELODYSPLASTIC syndromes , *MYELOPROLIFERATIVE neoplasms , *SKIN cancer , *METASTASIS , *PLASTIC surgery , *OPERATIVE surgery - Abstract
Skin cancer is the most common malignant neoplasm worldwide and basal cell carcinoma is the most frequent type with a benign behavior, on the contrary, giant basal cell carcinoma is a rare subtype that is characterized by an aggressive biological behavior with involvement to deep tissue and its metastatic potential is reported to be high. This paper reports the case of a patient with myelodysplastic and myeloproliferative syndrome with an unresponsive giant basal cell carcinoma that was excised by extensive surgery with a multidisciplinary team. In a second operation, reconstructive surgery was performed using a vascularized composite graft with functional preservation of the affected area. [ABSTRACT FROM AUTHOR]
- Published
- 2013
37. Giant Basal Cell Carcinoma of the Back: A Case Report and Review of the Literature.
- Author
-
Bogdanić, Branko, Smuđ, Sanda, Bagatin, Dinko, Nola, Marin, Mijatović, Davor, and Majerović, Matea
- Subjects
BASAL cell carcinoma ,SKIN cancer ,CANCER patients ,PERIODIC health examinations ,CANCER treatment ,SURGERY ,PATIENTS - Abstract
Copyright of Collegium Antropologicum is the property of Croatian Anthropological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2009
38. Female patient with two simultaneous giants facial basal cell carcinomas demonstrates a positive response to vismodegib as a monotherapy.
- Author
-
Theotokoglou, Sofia, Sgouros, Dimitrios, Theodoropoulos, Konstantinos, Syrmali, Anna, Polyderas, George, and Katoulis, Alexander
- Subjects
- *
METASTASIS , *TREATMENT effectiveness , *BASAL cell carcinoma , *BENZAMIDE - Abstract
Basal cell carcinoma (BCC) is the most frequent histological type of cancer in the world and accounts for approximately 80% of all skin cancers.In the majority of cases, they are slow-growing, low metastatic potential tumors, easy to cure by surgical or nonsurgical procedures.Giant BCC (GBCC) is a rare variant of BCC and according to the American Joint Committee on Cancer, this includes lesions with a diameter larger than 5 cm.GBCC's incidence has been reported to be less than 1%, and it displays a more aggressive behavior with both local invasion and higher metastatic potential.Archodaki et al.specifically reported that metastasis was present in 17.6% of GBCC patients during the primary examination. Patients with GBCC who are not suitable for either surgery or radiotherapy since 2012 seem to have another therapeutic option. Vismodegib is an oral small-molecule inhibitor of the Hedgehog pathway (HPI) that was approved for treating metastatic or locally advanced BCC in patients who are poor candidates for surgery or radiotherapy.In this case, we present a woman with two simultaneous facial GBCCs who was treated successfully using vismodegib as a monotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
39. Versatility of the O-Z flap for back reconstruction after giant basal cell carcinoma resection: A case report and review of the literature
- Author
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Giovanni Di Benedetto, Matteo Gioacchini, Matteo Torresetti, and Alessandro Scalise
- Subjects
Surgical resection ,medicine.medical_specialty ,business.industry ,Less invasive ,Patient characteristics ,medicine.disease ,Flap ,Article ,Resection ,Surgery ,O-Z flap ,03 medical and health sciences ,0302 clinical medicine ,Back reconstruction ,Giant basal cell carcinoma ,030220 oncology & carcinogenesis ,Soft tissue reconstruction ,medicine ,030211 gastroenterology & hepatology ,Basal cell carcinoma ,Basal cell ,business ,Perforator flaps - Abstract
Highlights • Giant basal cell carcinomas are rare and potentially aggressive tumors. • Aggressive surgical resection with suggested wide free margins is suggested. • Soft tissue reconstruction for back lesions may be challenging. • The O-Z flap represents a safe and reliable alternative for back reconstruction., Introduction Giant basal cell carcinomas are rare and potentially aggressive skin malignancies that are infrequently reported in the Literature, and they usually require aggressive surgical resection and immediate soft tissue reconstruction with skin grafts or flaps. The large size of GBCCs has relevant implications not only for the metastatic potential, but even for the reconstructive challenging due to the possible limited availability of tissues for flap coverage. Presentation of case We report the peculiar case of an old patient who underwent to GBCC resection of the back measuring 16 × 13 cm, and immediate reconstruction with a large O to Z flap harvested from the back; one-year follow-up examination revealed a satisfactory result and no recurrence of the disease was observed. Discussion The review of the Literature showed that reconstructive options are mainly determined by the site and extent of the defect, exposed structures and patient characteristics and comorbidities, and previous series reported the use of skin grafts only, pedicled myocutaneous or perforator flaps, exclusively free flaps and a combination of techniques. Therefore, in this scenario local flaps such as O-Z flaps are less invasive procedures, that usually have lower rate of postoperative complications and shorter hospitalization compared to more complex procedures. Conclusions Despite the use of O-Z flap is quite unusual for back reconstruction, we believe that this flap represents a valid and safe alternative in selected cases, particularly in the elderly and medically compromised patients with multiple comorbidities.
- Published
- 2019
40. Reappraisal of giant basal cell carcinoma: Clinical features and outcomes
- Author
-
Hoang Pham, Adèle C. Green, Titus Grecu, Donald Allan, Megan E. Grant, Clare Hodgson, Deemesh Oudit, and Andzhela Abu Rashed
- Subjects
Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,medicine.medical_treatment ,Cancer Care Facilities ,Photodynamic therapy ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Giant basal cell carcinoma ,Risk Factors ,medicine ,Humans ,Basal cell ,Basal cell carcinoma ,Age of Onset ,Surgical treatment ,Aggressive BCC ,Aged ,Retrospective Studies ,Aged, 80 and over ,Radiotherapy ,Manchester Cancer Research Centre ,business.industry ,ResearchInstitutes_Networks_Beacons/mcrc ,Margins of Excision ,Middle Aged ,medicine.disease ,Response to treatment ,Surgery ,Radiation therapy ,Natural history ,Treatment Outcome ,England ,Photochemotherapy ,Median time ,Carcinoma, Basal Cell ,030220 oncology & carcinogenesis ,Female ,Neoplasm Recurrence, Local ,business ,Clinical record - Abstract
Background: Giant basal cell carcinoma (GBCC) is a rare subgroup of basal cell carcinomas with a diameter of >5 cm. Current evidence about determining factors is conflicting, suggesting patient neglect, on the one hand, and biologically aggressive behaviour, on the other, with outcomes varying from clearance to death. We aimed to clarify the natural history of GBCC and its response to treatment. Methods: We extracted information from clinical records of all patients with GBCC treated from 1998 to 2017 in a tertiary oncology hospital in northwest England. Associations between patient and tumour characteristics were investigated, and modes of treatment and outcomes were assessed. Results: In the 20-year study period, 43 patients (median age 76 years; 23 (53%) female), 3 of whom had Gorlin syndrome, were treated for GBCCs. Median diameter was 6.3 cm, and median time to presentation was 5 years. Seven (16%) GBCCs arose from recurrent BCC, while the majority (84%) presented de novo. The size of GBCC was significantly correlated with delay in presentation (p = 0.03) but not with age or sex. Of 41 patients receiving definitive treatment, 19 GBCCs were treated by excision with ≤1 cm margin and none recurred during follow-up, compared with 10 recurrences of 23 treated with photodynamic therapy (PDT), and 1 of 7 recurred after radiotherapy. Two of 43 patients with GBCC (
- Published
- 2019
41. Giant Basal Cell Carcinoma in the Inguinal Region Invading the Femoral Vessels.
- Author
-
Ueda T, Kuro A, Kunieda S, Ozaki Y, Suzuki K, Hihara M, Komai H, and Kakudo N
- Abstract
Competing Interests: Disclosures: The authors disclose no financial or other conflicts of interest.
- Published
- 2022
42. Axial flap for giant basal cell carcinoma of the anterior chest wall: Case report.
- Author
-
Bellynda, Monica, Nugroho, Andhika Aji, Wiramur, Affandi, and Yarso, Kristanto Yuli
- Abstract
Anterior chest wall Giant Basal Cell Carcinoma (GBCC) is rare amongst GBCC cases and results in a large defect that is challenging to resect and reconstruct. It requires multidisciplinary approach to prevent recurrence. A 72-year-old man with giant basal cell carcinoma at the anterior chest wall measuring 10 × 6 cm. Wide resection of 1 cm margin with axial flap was performed to close the defect. The follow-up report stated that the patient was satisfied with the result and there was no recurrence observed. Review of literatures concludes that GBCC is excised with a minimum of 4-6 mm margin outside the tumor area. The axial IMAP flap is ideal to close the upper chest wall defect because of the better aesthetic outcome compared to other conventional flaps, especially in stable elderly male, patients with noninfected wound. Increased skin laxity and more relaxed skin tension associated with aging allows easier tissue mobilization and transfer to close the defect. Axial flap for GBCC in anterior chest wall is ideal, safe, and has the advantage of aesthetic reasons of suitable skin tone, particularly for stable elderly male patients. • A 72-year-old man presented with a seven-year history of ulcerating mass on his anterior chest wall. • Histopathologic examination confirmed the diagnosis of giant basal cell carcinoma (GBCC). • We performed wide resection with 1 cm margin and reconstruct the defect with axial flap. • No evidence of recurrence observed after 1 year of resection. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
43. Lethal giant basal cell carcinoma.
- Author
-
Byard RW, Wills S, and Gilbert JD
- Subjects
- Humans, Male, Middle Aged, Carcinoma, Basal Cell, Skin Neoplasms
- Abstract
Basal cell carcinomas are the most common malignancy in Caucasian populations with a very low predisposition to metastatic disease and an excellent prognosis if appropriately treated. Given the rarity of a lethal outcome two cases are reported. Case 1 : A 61-year-old reclusive man who had an untreated facial basal cell carcinoma for 10 years died of hypothermia and sepsis complicating the extensively ulcerated and infected tumour. He also had underlying cardiomegaly, ischaemic heart disease and chronic obstructive pulmonary disease. Case 2 : A 60-year-old man who had an untreated lower lumbar basal cell carcinoma for 14 years died of sepsis, inanition and pulmonary thromboembolism (due to a right-sided deep venous thrombosis) complicating the deeply ulcerated tumour. Untreated giant basal cell carcinoma may uncommonly present for medicolegal assessment with complex pathophysiological lethal mechanisms. The possibility of Diogenes syndrome should be considered.
- Published
- 2022
- Full Text
- View/download PDF
44. Giant Basal Cell Carcinoma of the Lumbosacral Region: A Case Report and Literature Review
- Author
-
Kamuran Zeynep Sevim, Kemal Ugurlu, Semra Karsidag, Arzu Akcal, and Selami Serhat Sirvan
- Subjects
business.industry ,lcsh:R ,lcsh:Surgery ,lcsh:Medicine ,Anatomy ,lcsh:RD1-811 ,medicine.disease ,Lumbosacral region ,Medicine ,Skin cancer ,Surgery ,Basal cell carcinoma ,giant basal cell carcinoma ,business - Abstract
Objective: Although frequently regarded as a low grade malignancy, basal cell carcinoma (BCC) sometimes shows aggressive behavior. Giant BCC is defined as a lesion greater then 5 centimeter. Material and Methods: The authors described the diagnosis and treatment protocol of giant BCC, involving lumbosacral region without any local or distant metastasis. Also the authors went through a thorough a retrospective literature research of giant BCCs in terms of frequency and treatment. Results: Giant BCCs are biologically more aggressive; however, patient’s negligence is a key factor for the tumor size. İnternational medical database (PubMed) search reveals 253 giant BCCs with the most commonly seen site as the face and back area. However perianal BCCs are seen lower then 1%. Conclusion: In general, diagnosed giant BCCs account for lower then 1% of all BCCs. One must keep in mind this diagnosis to discard the metastasis rate among BCCs.
- Published
- 2016
45. Case report. A rare case of giant basal cell carcinoma and malignant melanoma
- Author
-
Izzo, L., Izzo, S., Pugliese, F., and Izzo, P.
- Subjects
giant basal cell carcinoma ,malignant melanoma ,surgical treatment - Published
- 2018
46. Successful treatment of giant basal cell carcinoma with topical imiquimod 5% cream with long term follow-up
- Author
-
Tiffany Cheng, CH Li-Hua, Liao QiMan, M Chun-Guang, ZH Yu-Yun, and Han Jian-de
- Subjects
medicine.medical_specialty ,Imiquimod ,treatment ,business.industry ,Long term follow up ,Dermatology ,lcsh:RL1-803 ,medicine.disease ,Surgery ,Giant basal cell carcinoma ,Therapeutic Round ,medicine ,lcsh:Dermatology ,Basal cell carcinoma ,Topical imiquimod ,business ,skin and connective tissue diseases ,medicine.drug - Abstract
The use of the topical Imiquimod 5% cream offers a noninvasive, nonsurgical, and an effective option for the treatment of primary small (5 cm) BCC with topical Imiquimod 5% cream are rare. We present our experience in the treatment of two giant tumors (6 × 8 cm 2 , 5.2 × 4.2 cm 2 ) of BCC on the face with Imiquimod 5% cream, 2 to 3 days/week for 12 weeks. Both the tumors were cured with clinical and pathological evidence, one with 6-year follow-up and the other with 3.5-year follow-up.
- Published
- 2014
47. Saçlı Deride Gecikmiş Tanı: Dev Bazal Hücreli Karsinom.
- Author
-
Balcı, Didem Didar, Serarslan, Gamze, and Hakverdi, Sibel
- Subjects
- *
BASAL cell carcinoma , *SKIN cancer , *CANCER invasiveness , *ANTIFUNGAL agents , *ERYTHEMA , *ATHEROSCLEROTIC plaque , *SCALP , *DIAGNOSIS , *THERAPEUTICS - Abstract
Although basal cell carcinoma (BCC) is the most common form of skin cancer, the scalp lesions of BCC have been rarely reported. Giant BCC is defined as a tumor larger than 5 cm in diameter and only 0.5-1 % of all BCCs achieve this size. We report a case of giant BCC on the scalp that was treated with topical coticosteroids and antifungal shampoo for five years. BCC should be considered in the differential diagnosis in erythematous plaque type lesions resistant to therapy with long duration localized on the scalp. [ABSTRACT FROM AUTHOR]
- Published
- 2008
48. Giant exophytic basal cell carcinoma treated with radiotherapy.
- Author
-
Rossi, R, Campolmi, P, Giomi, B, Massi, D, and Cappugi, P
- Subjects
- *
BASAL cell carcinoma treatment , *RADIOTHERAPY , *SKIN tumors - Abstract
Abstract Basal cell carcinomas may attain giant proportions due primarily to recurrence or because the tumour is neglected. We report the case of a 66-year-old man who presented with a bleeding, polypoid, cutaneous tumour located on the left shoulder region of 13 years duration. The man had not received any previous treatment. The lesion was biopsied and histopathologically diagnosed as a solid type basal cell carcinoma with focal areas of squamous differentiation and keratinization. The man refused complete surgical removal and therefore was treated with roentgentherapy, with satisfactory results and no complications in the irradiated area. No recurrences had manifested after 1 year follow-up. [ABSTRACT FROM AUTHOR]
- Published
- 2002
- Full Text
- View/download PDF
49. GIANT BASAL CELL CARCINOMA ON THE FOREHEAD AND WHY WE SHOULD PREVENT THEM - CASE REPORT.
- Author
-
De Fré M, Vermeersch N, De F, Ulicki M, Smets K, Tondu T, and Thiessen F
- Subjects
- Carcinoma, Basal Cell diagnostic imaging, Carcinoma, Basal Cell surgery, Facial Neoplasms diagnostic imaging, Facial Neoplasms surgery, Forehead, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Skin Neoplasms diagnostic imaging, Skin Neoplasms surgery, Surgical Flaps, Tomography, X-Ray Computed, Carcinoma, Basal Cell prevention & control, Facial Neoplasms prevention & control, Skin Neoplasms prevention & control
- Abstract
Basal cell carcinoma (BCC) is the most prevalent malignancy, with rising incidence worldwide. Despite its naturally slow growth and initially low metastatic potential, it can cause significant morbidity and mortality when unrecognized, inadequately treated or poorly followed up. Authors present the case of a 61-year-old male with a 7-year history of multiple incomplete excisions of a “simple” BCC on the forehead. A CT scan of the head revealed an invasive mass (5.2 cm laterolateral x 4.0 cm craniocaudal) in the frontal area. There was no evidence of metastasis. Complete resection of the lesion and reconstruction was achieved in three stages. Final reconstruction was achieved using a left frontal fasciocutaneous flap. The secondary defect was closed with an advancement flap of the scalp and donor sites were covered using a split-thickness skin graft from the upper limb. This case demonstrates the necessity for vigilance in the approach to, diagnosis, treatment and follow-up of these skin neoplasms. The development of giant BCCs should be avoided at all costs. Increased size of BCCs corresponds with increased recurrence rate, metastatic rate, morbidity, mortality, treatment difficulties and overall costs.
- Published
- 2020
50. Metastatic giant basal cell carcinoma: a case report
- Author
-
Fadoua Rais, Ibrahim Elghissassi, Asmaa Lakhdissi, Benhmidou Naoual, Hind Mrabti, Othman Akkar, Khadija Bellahammou, and Hassan Errihani
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Lung Neoplasms ,Skin Neoplasms ,Early detection ,Antineoplastic Agents ,Case Report ,Malignancy ,Metastasis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Fatal Outcome ,Giant basal cell carcinoma ,medicine ,Humans ,metastasis ,Basal cell carcinoma ,Neoplasm Metastasis ,Aged ,lcsh:R5-920 ,Lung ,business.industry ,Systemic chemotherapy ,lcsh:Public aspects of medicine ,Rare entity ,lcsh:RA1-1270 ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Carcinoma, Basal Cell ,030220 oncology & carcinogenesis ,prognosis ,Skin cancer ,business ,lcsh:Medicine (General) - Abstract
Basal cell carcinoma is the most common skin cancer, characterised by a slow growing behavior, metastasis are extremely rare, and it occurs in less than 0, 1% of all cases.Giant basal cell carcinoma is a rare form of basal cell carcinoma, more aggressive and defined as a tumor measuring more than 5 cm at its largest diameter. Only 1% of all basal cell carcinoma develops to a giant basal cell carcinoma,resulting ofpatient's negligence. Giant basal cell carcinoma is associated with higher potential of metastasis and even death, compared to ordinary basal cell carcinoma.We report a case of giant basal cell carcinoma metastaticin lung occurringin a 79 years old male patient, with a fatal evolution after one course of systemic chemotherapy.Giant basal cell carcinoma is a very rare entity, early detection of these tumors could prevent metastasis occurrence and improve the prognosis of this malignancy.The Pan African Medical Journal 2016;24
- Published
- 2016
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