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Reappraisal of giant basal cell carcinoma: Clinical features and outcomes
- Source :
- Oudit, D, Pham, H, Grecu, T, Hodgson, C, Grant, M E, Rashed, A A, Allan, D & Green, A C 2020, ' Reappraisal of giant basal cell carcinoma : Clinical features and outcomes ', Journal of Plastic, Reconstructive and Aesthetic Surgery, vol. 73, no. 1, pp. 53-57 . https://doi.org/10.1016/j.bjps.2019.06.029
- Publication Year :
- 2019
-
Abstract
- Background: Giant basal cell carcinoma (GBCC) is a rare subgroup of basal cell carcinomas with a diameter of >5 cm. Current evidence about determining factors is conflicting, suggesting patient neglect, on the one hand, and biologically aggressive behaviour, on the other, with outcomes varying from clearance to death. We aimed to clarify the natural history of GBCC and its response to treatment. Methods: We extracted information from clinical records of all patients with GBCC treated from 1998 to 2017 in a tertiary oncology hospital in northwest England. Associations between patient and tumour characteristics were investigated, and modes of treatment and outcomes were assessed. Results: In the 20-year study period, 43 patients (median age 76 years; 23 (53%) female), 3 of whom had Gorlin syndrome, were treated for GBCCs. Median diameter was 6.3 cm, and median time to presentation was 5 years. Seven (16%) GBCCs arose from recurrent BCC, while the majority (84%) presented de novo. The size of GBCC was significantly correlated with delay in presentation (p = 0.03) but not with age or sex. Of 41 patients receiving definitive treatment, 19 GBCCs were treated by excision with ≤1 cm margin and none recurred during follow-up, compared with 10 recurrences of 23 treated with photodynamic therapy (PDT), and 1 of 7 recurred after radiotherapy. Two of 43 patients with GBCC (
- Subjects :
- Adult
Male
medicine.medical_specialty
Skin Neoplasms
medicine.medical_treatment
Cancer Care Facilities
Photodynamic therapy
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Giant basal cell carcinoma
Risk Factors
medicine
Humans
Basal cell
Basal cell carcinoma
Age of Onset
Surgical treatment
Aggressive BCC
Aged
Retrospective Studies
Aged, 80 and over
Radiotherapy
Manchester Cancer Research Centre
business.industry
ResearchInstitutes_Networks_Beacons/mcrc
Margins of Excision
Middle Aged
medicine.disease
Response to treatment
Surgery
Radiation therapy
Natural history
Treatment Outcome
England
Photochemotherapy
Median time
Carcinoma, Basal Cell
030220 oncology & carcinogenesis
Female
Neoplasm Recurrence, Local
business
Clinical record
Subjects
Details
- ISSN :
- 18780539
- Volume :
- 73
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of plastic, reconstructiveaesthetic surgery : JPRAS
- Accession number :
- edsair.doi.dedup.....b9cbd825b9e756193e93a473bd5600d3