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47 results on '"Franks, N.P."'

1. Neurons in prefrontal cortex respond to sleep deprivation by initiating sleep preparatory behaviour and NREM sleep

Author

Tossell, K., primary, Yu, X., additional, Anuncibay Soto, B., additional, Vicente, M., additional, Miracca, G., additional, Giannos, P., additional, Miao, A., additional, Hsieh, B., additional, Ma, Y., additional, Yustos, R., additional, Vyssotski, A.L., additional, Constandinou, T., additional, Franks, N.P., additional, and Wisden, W., additional

Published
2022
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4. Molecular and cellular mechanisms of general anaesthesia

Author

Franks, N.P. and Lieb, W.R.

Subjects
Anesthetics -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

General anesthetics at clinical concentration affects a few central nervous system targets such as the postsynaptic ligand-gated ion channels, and its influence is felt in the cellular and molecular levels. Voltage-gated ion channels exhibit greater resistance to clinical concentrations. Anesthetic activities vary from neuron to neuron at the cellular level while at the molecular level, anesthetics link to the proteins directly.

Published
1994

7. Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels

Author

Franks, N.P. and Lieb, W.R.

Subjects
Physiological aspects, Research, Anesthetics -- Physiological aspects -- Research, Enantiomers -- Physiological aspects -- Research, Ion channels -- Research -- Physiological aspects
Abstract

THE POSSIBILITY THAT OPTICAL ISO-mers of inhalational general anesthetics might display differential biological activities has generally been discounted because of the traditional view that general anesthetics act by nonspecific perturbation [...]

Published
1991

11. Staying awake: a genetic region that hinders α2 adrenergic receptor agonist-induced loss of consciousness

Author

Gelegen, C., Gent, T.C., Ferretti, V., Zhang, Z., Yustos, R., Lan, F., Yang, Q., Overington, D.W.U., Vyssotsky, A.L., van Lith, H.A., Wisden, W., Franks, N.P., Emotion and Cognition, LS Dierenwelzijn & Proefdierkunde, Dep of Animals in Science and Society, and ASS E&C2

Subjects
sedation, wakefulness, alpha2a adrenergic receptor, sleep
Abstract

How external stimuli prevent the onset of sleep has been little studied. This is usually considered to be a non-specific type of phenomenon. However, the hypnotic drug dexmedetomidine, an agonist at a2 adrenergic receptors, has unusual properties that make it useful for investigating this question. Dexmedetomidine is considered to produce an ‘arousable’ sleep-like state, so that patients or animals given dexmedetomidine become alert following modest stimulation. We hypothesized that it might be more difficult to make mice unconscious with dexmedetomidine if there was a sufficient external stimulus. Employing a motorized rotating cylinder, which provided a continuous and controlled arousal stimulus, we quantitatively measured the ability of such a stimulus to prevent dexmedetomidine loss of righting reflex in two inbred strains of mice (C57BL/6 and 129X1). We found that whereas the C57BL/6 strain required a strong stimulus to prevent dexmedetomidine-induced hypnosis, the 129X1 strain stayed awake even with minimal stimuli. Remarkably, this could be calibrated as a simple threshold trait, i.e. a binary ‘yes–no’ response, which after crossing the two mouse strains behaved as a dominant-like trait. We carried out a genome-wide linkage analysis on the F2 progeny to determine if the ability of a stimulus to prevent dexmedetomidine hypnosis could be mapped to one or more chromosomal regions. We identified a locus on chromosome 4 with an associated Logarithm of Odds score exceeding the pre-established threshold level. These results show that complex traits, such as the ability of a stimulus to reverse drug-induced hypnosis, may have precise genetic determinants.

Published
2014

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Author

Emotion and Cognition, LS Dierenwelzijn & Proefdierkunde, Dep of Animals in Science and Society, ASS E&C2, Gelegen, C., Gent, T.C., Ferretti, V., Zhang, Z., Yustos, R., Lan, F., Yang, Q., Overington, D.W.U., Vyssotsky, A.L., van Lith, H.A., Wisden, W., Franks, N.P., Emotion and Cognition, LS Dierenwelzijn & Proefdierkunde, Dep of Animals in Science and Society, ASS E&C2, Gelegen, C., Gent, T.C., Ferretti, V., Zhang, Z., Yustos, R., Lan, F., Yang, Q., Overington, D.W.U., Vyssotsky, A.L., van Lith, H.A., Wisden, W., and Franks, N.P.

Published
2014

14. Anaesthetics set their sites on ion channels

Author

Franks, N.P. and Lieb, W.R.

Subjects
Synapses -- Research, Anesthetics -- Research, GABA -- Receptors, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The main inhibitory neurotransmitters in the spinal cord and brain are glycine and gamma-aminobutyric acid and the function of their respective receptor brain proteins are enhanced by anaesthetics which reduce the functions of related receptors. Chimaeric constructs are used to support the theory that general anaesthetics are not nonspecific as previously thought.

Published
1997

15. Effects of isoflurane and xenon on Ba 2+ -currents mediated by N-type calcium channels † †Declaration of interest. Professor Franks is a board member of an Imperial College spin-out company, Protexeon Ltd, that is interested in developing clinical applications for medical gases, including xenon. Professor Franks is a paid consultant in this activity. In addition Air Products have funded work in the authors’ laboratories that bears on the actions of xenon as an anaesthetic and neuroprotectant. Air Products has a financial stake in Protexeon Ltd.

Author

White, I.L., primary, Franks, N.P., additional, and Dickinson, R, additional

Published
2005
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20. How does xenon produce anaesthesia?

Author

Franks, N.P., Dickinson, R., de Sousa, S.L.M., Hall, A.C., and Lieb, W.R.

Subjects
Xenon -- Physiological aspects, Anesthesiology -- Observations, Anesthetics -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The molecular mechanism associated with the clinical activity of the anaesthetic gas xenon have remained poorly understood since its discovery. Most general anaesthetics heighten the activity of inhibitory GABA (gamma-aminobutyric acid type-A), but a new study shows that xenon has little effect on GABA, instead inhibiting the excitory NMDA (N-methyl-D-aspartate) receptor channels, which may partially explain some important features of its pharmacology, particularly its lack of undesirable side effects.

Published
1998

44. Ion channels and inhalational anaesthetics: molecular mechanisms of action.

Author

Franks, N.P.

Subjects
ANESTHETICS, ION channels, PROTEINS
Abstract

Describes the molecular mechanisms of action of inhalational anesthetics in ion channels. Binding of anesthetics to preformed hydrophobic or amphiphilic pockets on proteins; Degree of stereoselectivity of anesthetics in their effects on ion channels; Nature and identity of anesthetics binding sites in the central nervous systems.

Published
2000

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