88 results on '"De Los Rios J"'
Search Results
2. Outcome of treatment of MDR-TB or drug-resistant patients treated with bedaquiline and delamanid: Results from a large global cohort
- Author
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Koirala, S., Borisov, S., Danila, E., Mariandyshev, A., Shrestha, B., Lukhele, N., Dalcolmo, M., Shakya, S.R., Miliauskas, S., Kuksa, L., Manga, S., Aleksa, A., Denholm, J.T., Khadka, H.B., Skrahina, A., Diktanas, S., Ferrarese, M., Bruchfeld, J., Koleva, A., Piubello, A., Koirala, G.S., Udwadia, Z.F., Palmero, D.J., Munoz-Torrico, M., GC, R., Gualano, G., Grecu, V.I., Motta, I., Papavasileiou, A., Li, Y., Hoefsloot, W., Kunst, H., Mazza-Stalder, J., Payen, M.-C., Akkerman, O.W., Bernal, E., Manfrin, V., Matteelli, A., Mustafa Hamdan, H., Nieto Marcos, M., Cadiñanos Loidi, J., Cebrian Gallardo, J.J., Duarte, R., Escobar Salinas, N., Gomez Rosso, R., Laniado-Laborín, R., Martínez Robles, E., Quirós Fernandez, S., Rendon, A., Solovic, I., Tadolini, M., Viggiani, P., Belilovski, E., Boeree, M.J., Cai, Q., Davidavičienė, E., Forsman, L.D., De Los Rios, J., Drakšienė, J., Duga, A., Elamin, S.E., Filippov, A., Garcia, A., Gaudiesiute, I., Gavazova, B., Gayoso, R., Gruslys, V., Jonsson, J., Khimova, E., Madonsela, G., Magis-Escurra, C., Marchese, V., Matei, M., Moschos, C., Nakčerienė, B., Nicod, L., Palmieri, F., Pontarelli, A., Šmite, A., Souleymane, M.B., Vescovo, M., Zablockis, R., Zhurkin, D., Alffenaar, J.-W., Caminero, J.A., Codecasa, L.R., García-García, J.-M., Esposito, S., Saderi, L., Spanevello, A., Visca, D., Tiberi, S., Pontali, E., Centis, R., D'Ambrosio, L., van den Boom, M., Sotgiu, G., and Migliori, G.B.
- Published
- 2021
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3. On the use of a roving body with rotary inertia to locate cracks in beams
- Author
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Cannizzaro, F., De Los Rios, J., Caddemi, S., Caliò, I., and Ilanko, S.
- Published
- 2018
- Full Text
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4. Synthesis of Ni–TiO2 Nanocomposites as Enzyme–Less, Amperometric Sensors for the Electrooxidation of Glucose
- Author
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de los Rios, J. P., primary, Galvan, Vicente, additional, and Prakash, G. K. Surya, additional
- Published
- 2023
- Full Text
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5. Use of Avocado to Obtain an Ammonium Quaternary Salt as CO2-Corrosion Inhibitor of a Duplex Stainless Steel.
- Author
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Brito-Franco, A., Vazquez-Velez, E., Florez-De los Rios, J. P., Landeros-Martínez, L. L., and Gonzalez-Rodriguez, J. G.
- Published
- 2023
- Full Text
- View/download PDF
6. Proposal of a Computing Model Using GRID Resources for the JEM-EUSO Space Mission
- Author
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de los Ríos, J. A. Morales, Frías, M. D. Rodríguez, del Peral, L., Prieto, H., Sáez-Cano, G., Putnik, Goran D., editor, and Cruz-Cunha, Maria Manuela, editor
- Published
- 2012
- Full Text
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7. Brain contusions induce a strong local overexpression of MMP-9. Results of a pilot study
- Author
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Vilalta, A., Sahuquillo, J., Poca, M. A., De Los Rios, J., Cuadrado, E., Ortega-Aznar, A., Riveiro, M., Montaner, J., and Steiger, H. -J., editor
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- 2009
- Full Text
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8. Effect of SGLT2 inhibitors on stroke and atrial fibrillation in diabetic kidney disease: Results from the CREDENCE trial and meta-analysis
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Zhou, Z, Jardine, M, Li, Q, Neuen, B, Cannon, C, De Zeeuw, D, Edwards, R, Levin, A, Mahaffey, K, Perkovic, V, Neal, B, Lindley, R, Guerrero, R, Aizenberg, D, Albisu, J, Alvarisqueta, A, Bartolacci, I, Berli, M, Bordonava, A, Calella, P, Cantero, M, Cartasegna, L, Cercos, E, Coloma, G, Colombo, H, Commendatore, V, Cuadrado, J, Cuneo, C, Cusumano, A, Douthat, W, Dran, R, Farias, E, Fernandez, M, Finkelstein, H, Fragale, G, Fretes, J, Garcia, N, Gastaldi, A, Gelersztein, E, Glenny, J, Gonzalez, J, Del Carmen Gonzalez Colaso, P, Goycoa, C, Greloni, G, Guinsburg, A, Hermida, S, Juncos, L, Klyver, M, Kraft, F, Krynski, F, Lanchiotti, P, De La Fuente, R, Marchetta, N, Mele, P, Nicolai, S, Novoa, P, Orio, S, Otreras, F, Oviedo, A, Raffaele, P, Resk, J, Rista, L, Papini, N, Sala, J, Santos, J, Schiavi, L, Sessa, H, Casabella, T, Ulla, M, Valdez, M, Vallejos, A, Villarino, A, Visco, V, Wassermann, A, Zaidman, C, Cheung, N, Droste, C, Fraser, I, Johnson, D, Mah, P, Nicholls, K, Packham, D, Proietto, J, Roberts, A, Roger, S, Tsang, V, Raduan, R, Da Costa, F, Amodeo, C, Turatti, L, Bregman, R, Sanches, F, Canani, L, Chacra, A, Borges, J, Vencio, S, Da Silva Franco, R, D'Avila, D, De Souza Portes, E, De Souza, P, Deboni, L, Filho, F, Neto, B, Gomes, M, Kohara, S, Keitel, E, Saraiva, J, Lisboa, H, De Carvalho Contieri, F, Milagres, R, Junior, R, De Brito, C, Hissa, M, Sabbag, A, Noronha, I, Panarotto, D, Filho, R, Pereira, M, Saporito, W, Scotton, A, Schuch, T, De Almeida, R, Ramos, C, Felicio, J, Thome, F, Hachmann, J, Yamada, S, Hayashida, C, Petry, T, Zanella, M, Andreeva, V, Angelova, A, Dimitrov, S, Genadieva, V, Genova-Hristova, G, Hristozov, K, Kamenov, Z, Koundurdjiev, A, Lozanov, L, Margaritov, V, Nonchev, B, Rangelov, R, Shinkov, A, Temelkova, M, Velichkova, E, Yakov, A, Aggarwal, N, Aronson, R, Bajaj, H, Cherney, D, Chouinard, G, Conway, J, Cournoyer, S, Daroza, G, De Serres, S, Dube, F, Goldenberg, R, Gupta, A, Gupta, M, Henein, S, Khandwala, H, Leiter, L, Madore, F, Mc-Mahon, A, Muirhead, N, Pichette, V, Rabasa-Lhoret, R, Steele, A, Tangri, N, Torshizi, A, Woo, V, Zalunardo, N, Montenegro, M, Jorquera, J, Farina, M, Gajardo, V, Vejar, M, Chen, N, Chen, Q, Gan, S, Kong, Y, Li, D, Li, W, Li, X, Lin, H, Liu, J, Lu, W, Mao, H, Ren, Y, Song, W, Sun, J, Sun, L, Tu, P, Wang, G, Yang, J, Yin, A, Yu, X, Zhao, M, Zheng, H, Mendoza, J, Arcos, E, Avendano, J, Ruiz, J, Ortiz, L, Gonzalez, A, Triana, E, Higuera, J, Malaver, N, De Salazar, D, Rosero, R, Lozano, M, Cometa, L, Valenzuela, A, Alonso, R, Villegas, I, Yupanqui, H, Bartaskova, D, Barton, P, Belobradkova, J, Dohnalova, L, Drasnar, T, Ferkl, R, Halciakova, K, Klokocnikova, V, Kovar, R, Lastuvka, J, Lukac, M, Pesickova, S, Peterka, K, Pumprla, J, Rychlik, I, Saudek, F, Tesar, V, Valis, M, Weiner, P, Zemek, S, Alamartine, E, Borot, S, Cariou, B, Dussol, B, Fauvel, J, Gourdy, P, Klein, A, Le Meur, Y, Penfornis, A, Roussel, R, Saulnier, P, Thervet, E, Zaoui, P, Burst, V, Faghih, M, Faulmann, G, Haller, H, Jerwan-Keim, R, Maxeiner, S, Paschen, B, Plassmann, G, Rose, L, Orellana, R, Haase, F, Diaz, J, Roca, L, Arenales, J, Polo, J, Juarez, E, Csecsei, G, Csiky, B, Danos, P, Deak, L, Dudas, M, Harcsa, E, Keltai, K, Keresztesi, S, Kiss, K, Konyves, L, Major, L, Mileder, M, Molnar, M, Mucsi, J, Oroszlan, T, Ory, I, Paragh, G, Peterfai, E, Petro, G, Revesz, K, Takacs, R, Vangel, S, Vasas, S, Zsom, M, Oomman, A, Raju, S, Dewan, D, Fernando, M, Gopalakrishnan, N, Gracious, N, Alva, H, Jain, D, Keshavamurthy, C, Khullar, D, Sahay, M, Peringat, J, Prasad, N, Rao, K, Reddy, S, Melemadathil, S, Sudhakar, B, Vyasam, R, Bonadonna, R, Castellino, P, Ceriello, A, Chiovato, L, De Cosmo, S, De Nicola, L, Derosa, G, Carlo, A, Cianni, G, Frasca, G, Fuiano, G, Gambaro, G, Garibotto, G, Giorda, C, Malberti, F, Mandreoli, M, Mannucci, E, Orsi, E, Piatti, P, Santoro, D, Sasso, F, Serviddio, G, Stella, A, Trevisan, R, Veronelli, A, Zanoli, L, Akiyama, H, Aoki, H, Asano, A, Iitsuka, T, Kajiyama, S, Kashine, S, Kawada, T, Kodera, T, Kono, H, Koyama, K, Kumeda, Y, Miyauchi, S, Mizuyama, K, Niiya, T, Oishi, H, Ota, S, Sakakibara, T, Takai, M, Tomonaga, O, Tsujimoto, M, Wada, T, Wakasugi, M, Wakida, Y, Watanabe, T, Yamada, M, Yanagida, K, Yanase, T, Yumita, W, Gaupsiene, E, Kozloviene, D, Navickas, A, Urbanaviciene, E, Ghani, R, Kadir, K, Ali, N, Yusof, M, Gan, C, Ismail, M, Kong, W, Lam, S, Lee, L, Lim, S, Loh, C, Manocha, A, Ng, K, Ahmad, N, Ratnasingam, V, Shudim, S, Vengadasalam, P, Munoz, L, Salazar, M, Cruz, J, Soto, M, Ramos, J, Wong, A, Rotter, J, Escalante, T, Sosa, F, Lozano, F, Cervera, L, Baron, P, Ballesteros, C, Rangel, J, Jimenez, L, Santana, S, Flores, F, Molina, H, Ceballos, R, Del Campo Blanco, B, Franco, G, Loza, O, Rocha, C, Vera, G, Castellanos, R, Calcaneo, J, Rosano, M, Pattzi, H, Guzman, J, Joerg, I, Sanchez, S, Mijangos, J, Sanson, P, Tamayo Y Orozco, J, Chavez, E, Cepeda, A, Carrillo, L, Mesa, J, Escobedo, R, Baker, J, Noonan, P, Scott, R, Walker, R, Watson, E, Williams, M, Young, S, Abejuela, Z, Agra, J, Aquitania, G, Caringal, C, Comia, R, Santos, L, Gomez, O, Jimeno, C, Santos, F, Tan, G, Tolentino, M, Yao, C, Yap, Y, Ygpuara, M, Bijata-Bronisz, R, Hotlos, L, Januszewicz, A, Kaczmarek, B, Kaminska, A, Lazuka, L, Madej, A, Mazur, S, Mlodawska-Choluj, D, Nowicki, M, Orlowska-Kowalik, G, Popenda, G, Rewerska, B, Sowinski, D, Angelescu, L, Anghel, V, Avram, R, Busegeanu, M, Cif, A, Cosma, D, Crisan, C, Demian, L, Ferariu, I, Halmagyi, I, Hancu, N, Munteanu, M, Negru, D, Onaca, A, Petrica, L, Popa, A, Ranetti, A, Serafinceanu, C, Toarba, C, Agafyina, A, Barbarash, O, Barysheva, O, Chizhov, D, Dobronravov, V, Dreval, A, Glinkina, I, Grineva, E, Khirmanov, V, Kolmakova, E, Koroleva, T, Kvitkova, L, Marasaev, V, Mkrtumyan, A, Morugova, T, Nagibovich, G, Nagibovich, O, Nedogoda, S, Osipova, I, Raskina, T, Samoylova, Y, Sazonova, O, Shamkhalova, M, Shutemova, E, Shwartz, Y, Uriasyev, O, Vorobyev, S, Zateyshchikova, A, Zateyshshikov, D, Zykova, T, Antic, S, Djordjevic, M, Kendereski, A, Lalic, K, Lalic, N, Popovic-Radinovic, V, Babikova, J, Benusova, O, Buganova, I, Culak, J, Dzupina, A, Dzuponova, J, Fulop, P, Ilavska, A, Martinka, E, Ochodnicka, Z, Pella, D, Smatanova, I, Ahmed, F, Badat, A, Breedt, J, Distiller, L, Govender, V, Govender, R, Joshi, M, Jurgens, J, Latiff, G, Lombard, L, Mookadam, M, Ngcakani, N, Nortje, H, Oosthuizen, H, Pillay-Ramaya, L, Prozesky, H, Reddy, J, Rheeder, P, Seeber, M, Chae, D, Cho, Y, Jeong, I, Kim, S, Kim, Y, Kwon, H, Kwon, M, Lee, B, Lee, J, Lee, M, Nam, M, Oh, K, Park, C, Park, S, Yoon, K, Garcia, P, Mercadal, L, Barrios, C, Castro, F, Guldris, S, Lopez, M, De Los Rios, J, Fresnedo, G, Serrano, A, Garcia, I, Martinez, F, Gimeno, J, Mendoza, M, Marin, T, Portillo, C, Vila, M, Torres, M, Iglesias, J, Perez, J, Vera, M, Simon, M, Canonge, R, Riera, M, Madueno, F, Plaza, M, Chang, C, Chuang, L, Hsia, T, Hsieh, C, Hwang, S, Lin, C, Lu, Y, Sheu, W, Barna, O, Bilyk, S, Botsyurko, V, Dudar, I, Fushtey, I, Godlevska, O, Golovchenko, O, Gyrina, O, Kazmirchuk, A, Kolesnyk, M, Komisarenko, I, Korzh, O, Kravchun, N, Legun, O, Mankovskyy, B, Martynyuk, L, Mostovoy, Y, Pashkovska, N, Pererva, L, Pertseva, T, Samoylov, O, Smirnov, I, Svyshchenko, Y, Tomashkevych, H, Topchii, I, Tryshchuk, N, Tseluyko, V, Vizir, V, Vlasenko, M, Zlova, T, Zub, L, Abusnana, S, Railey, M, Abouglila, K, Ainsworth, P, Ali, Z, Arutchelvam, V, Barnard, M, Bellary, S, Davies, E, Davies, M, Davies, S, Dawson, A, Kossi, M, English, P, Fraser, D, Gnudi, L, Gunstone, A, Hall, T, Hanif, W, Jackson, A, Johnson, A, Joseph, F, Krishnan, S, Kumwenda, M, Macdougall, I, Nixon, P, O'Hare, J, Philip, S, Ramtoola, S, Saxena, M, Sennik, D, Simon, G, Singh, B, Stephens, J, Strzelecka, A, Symonds, R, Turner, W, Wahba, M, Wakeling, J, Wheeler, D, Winocour, P, Abdallah, J, Abdullah, R, Abramowitz, M, Acosta, I, Aiello, J, Akright, L, Akyea-Djamson, A, Alappan, R, Alicic, R, Al-Karadsheh, A, Allison, D, Arauz-Pacheco, C, Arfeen, S, Arif, A, Arvind, M, Atray, N, Awad, A, Bakris, G, Barnhill, P, Barranco, E, Barrera, C, Beacom, M, Behara, V, Belo, D, Bentley-Lewis, R, Berenguer, R, Bermudez, L, Bernardo, M, Biscoveanu, M, Bowman-Stroud, C, Brandon, D, Brusco, O, Busch, R, Canaan, Y, Chilito, A, Christensen, T, Christiano, C, Christofides, E, Chuateco, C, Cohen, K, Cohen, R, Cohen-Stein, D, Cook, C, Coyne, D, Daboul, N, Darwish, R, Daswani, A, Deck, K, Desouza, C, Dev, D, Dhillon, M, Dua, S, Eder, F, Elosegui, A, El-Shahawy, M, Ervin, J, Esquenazi, A, Evans, J, Fishbane, S, Frias, J, Galindo-Ramos, E, Galphin, C, Ghazi, A, Gonzalez, E, Gorson, D, Gowda, A, Greco, B, Grubb, S, Gulati, R, Hammoud, J, Handelsman, S, Hartman, I, Hershon, K, Hiser, D, Hon, G, Jacob, R, Jaime, M, Jamal, A, Kaupke, C, Keightley, G, Kern, E, Khanna, R, Khitan, Z, Kopyt, N, Kovesdy, C, Krishna, G, Kropp, J, Kumar, A, Kumar, J, Kumar, N, Kusnir, J, Lane, W, Lawrence, M, Lehrner, L, Lentz, J, Levinson, D, Lewis, D, Liss, K, Maddux, A, Maheshwari, H, Mandayam, S, Marar, I, Mehta, B, Middleton, J, Mordujovich, J, Moreda, R, Moustafa, M, Trenche, S, Narayanan, M, Narvarte, J, Nassar, T, Newman, G, Nichol, B, Nicol, P, Nisnisan, J, Nossuli, A, Obialo, C, Olelewe, S, Oliver, M, O'Shaughnessy, A, Padron, J, Pankhaniya, R, Parker, R, Patel, D, Patel, G, Patel, N, Pavon, H, Perez, A, Perez, C, Perlman, A, Pettis, K, Pharr, W, Phillips, A, Purighalla, R, Quesada-Suarez, L, Ranjan, R, Rastogi, S, Rendell, M, Rich, L, Robinson, M, Rodriguez, H, Rosas, S, Saba, F, Sankaram, R, Sarin, R, Schreiman, R, Scott, D, Sekkarie, M, Sensenbrenner, J, Shakeel, M, Shanik, M, Shaw, S, Smith, S, Solomon, R, Sprague, A, Spry, L, Suchinda, P, Sultan, S, Surampudi, P, Sussman, S, Tan, A, Terrelonge, A, Thompson, M, Trespalacios, F, Trippe, B, Trueba, P, Twahirwa, M, Updegrove, J, Van Buren, P, Vannorsdall, M, Varghese, F, Velasquez-Mieyer, P, Ventrapragada, S, Vukotic, G, Wadud, K, Warren, M, Watson, H, Watts, R, Weiner, D, Welker, J, Welsh, J, Williams, S, Zaniewski-Singh, M, Zhou Z., Jardine M. J., Li Q., Neuen B. L., Cannon C. P., De Zeeuw D., Edwards R., Levin A., Mahaffey K. W., Perkovic V., Neal B., Lindley R. I., Guerrero R. A. A., Aizenberg D., Albisu J. P., Alvarisqueta A., Bartolacci I., Berli M. A., Bordonava A., Calella P., Cantero M. C., Cartasegna L. R., Cercos E., Coloma G. C., Colombo H., Commendatore V., Cuadrado J., Cuneo C. A., Cusumano A. M., Douthat W. G., Dran R. D., Farias E., Fernandez M. F., Finkelstein H., Fragale G., Fretes J. O., Garcia N. H., Gastaldi A., Gelersztein E., Glenny J. A., Gonzalez J. P., Del Carmen Gonzalez Colaso P., Goycoa C., Greloni G. C., Guinsburg A., Hermida S., Juncos L. I., Klyver M. I., Kraft F., Krynski F., Lanchiotti P. V., De La Fuente R. A. L., Marchetta N., Mele P., Nicolai S., Novoa P. A., Orio S. I., Otreras F., Oviedo A., Raffaele P., Resk J. H., Rista L., Papini N. R., Sala J., Santos J. C., Schiavi L. B., Sessa H., Casabella T. S., Ulla M. R., Valdez M., Vallejos A., Villarino A., Visco V. E., Wassermann A., Zaidman C. J., Cheung N. W., Droste C., Fraser I., Johnson D., Mah P. M., Nicholls K., Packham D., Proietto J., Roberts A., Roger S., Tsang V., Raduan R. A., Da Costa F. A. A., Amodeo C., Turatti L. A. A., Bregman R., Sanches F. C. C., Canani L. H., Chacra A. R., Borges J. L. C., Vencio S. A. C., Da Silva Franco R. J., D'Avila D., De Souza Portes E., De Souza P., Deboni L. M., Filho F. F., Neto B. G., Gomes M., Kohara S. K., Keitel E., Saraiva J. F. K., Lisboa H. R. K., De Carvalho Contieri F. L., Milagres R., Junior R. M., De Brito C. M., Hissa M. N., Sabbag A. R. N., Noronha I., Panarotto D., Filho R. P., Pereira M. A., Saporito W., Scotton A. S., Schuch T., De Almeida R. S., Ramos C. S., Felicio J. S., Thome F., Hachmann J. C. T., Yamada S., Hayashida C. Y., Petry T. B. Z., Zanella M. T., Andreeva V., Angelova A., Dimitrov S., Genadieva V., Genova-Hristova G., Hristozov K., Kamenov Z., Koundurdjiev A., Lozanov L., Margaritov V., Nonchev B., Rangelov R., Shinkov A., Temelkova M., Velichkova E., Yakov A., Aggarwal N., Aronson R., Bajaj H., Cherney D., Chouinard G., Conway J., Cournoyer S., DaRoza G., De Serres S., Dube F., Goldenberg R., Gupta A., Gupta M., Henein S., Khandwala H., Leiter L., Madore F., Mc-Mahon A., Muirhead N., Pichette V., Rabasa-Lhoret R., Steele A., Tangri N., Torshizi A., Woo V., Zalunardo N., Montenegro M. A. F., Jorquera J. G. G., Farina M. M., Gajardo V. S., Vejar M., Chen N., Chen Q., Gan S., Kong Y., Li D., Li W., Li X., Lin H., Liu J., Lu W., Mao H., Ren Y., Song W., Sun J., Sun L., Tu P., Wang G., Yang J., Yin A., Yu X., Zhao M., Zheng H., Mendoza J. L. A., Arcos E., Avendano J., Ruiz J. E. A. D., Ortiz L. H. G., Gonzalez A., Triana E. H., Higuera J. D., Malaver N., De Salazar D. I. M., Rosero R., Lozano M. A. T., Cometa L. V., Valenzuela A., Alonso R. D. V., Villegas I., Yupanqui H., Bartaskova D., Barton P., Belobradkova J., Dohnalova L., Drasnar T., Ferkl R., Halciakova K., Klokocnikova V., Kovar R., Lastuvka J., Lukac M., Pesickova S., Peterka K., Pumprla J., Rychlik I., Saudek F., Tesar V., Valis M., Weiner P., Zemek S., Alamartine E., Borot S., Cariou B., Dussol B., Fauvel J. -P., Gourdy P., Klein A., Le Meur Y., Penfornis A., Roussel R., Saulnier P. -J., Thervet E., Zaoui P., Burst V., Faghih M., Faulmann G., Haller H., Jerwan-Keim R., Maxeiner S., Paschen B., Plassmann G., Rose L., Orellana R. A. G., Haase F. P., Diaz J. P. M., Roca L. A. R., Arenales J. A. S., Polo J. V. S., Juarez E. T., Csecsei G., Csiky B., Danos P., Deak L., Dudas M., Harcsa E., Keltai K., Keresztesi S., Kiss K., Konyves L., Major L., Mileder M., Molnar M., Mucsi J., Oroszlan T., Ory I., Paragh G., Peterfai E., Petro G., Revesz K., Takacs R., Vangel S., Vasas S., Zsom M., Oomman A., Raju S. B., Dewan D., Fernando M. E., Gopalakrishnan N., Gracious N., Alva H., Jain D., Keshavamurthy C. B., Khullar D., Sahay M., Peringat J., Prasad N., Rao K. S., Reddy S., Melemadathil S., Sudhakar B., Vyasam R. C., Bonadonna R., Castellino P., Ceriello A., Chiovato L., De Cosmo S., De Nicola L., Derosa G., Carlo A. D., Cianni G. D., Frasca G., Fuiano G., Gambaro G., Garibotto G., Giorda C., Malberti F., Mandreoli M., Mannucci E., Orsi E., Piatti P., Santoro D., Sasso F. C., Serviddio G., Stella A., Trevisan R., Veronelli A. M., Zanoli L., Akiyama H., Aoki H., Asano A., Iitsuka T., Kajiyama S., Kashine S., Kawada T., Kodera T., Kono H., Koyama K., Kumeda Y., Miyauchi S., Mizuyama K., Niiya T., Oishi H., Ota S., Sakakibara T., Takai M., Tomonaga O., Tsujimoto M., Wada T., Wakasugi M., Wakida Y., Watanabe T., Yamada M., Yanagida K., Yanase T., Yumita W., Gaupsiene E., Kozloviene D., Navickas A., Urbanaviciene E., Ghani R. A., Kadir K. A., Ali N., Yusof M. D. C., Gan C. L., Ismail M., Kong W. Y., Lam S. W., Lee L. Y., Lim S. K., Loh C. L., Manocha A. B., Ng K. S., Ahmad N. N. F. N., Ratnasingam V., Shudim S. S. B., Vengadasalam P., Munoz L. D. A., Salazar M. A., Cruz J. B., Soto M. B., Ramos J. C., Wong A. C., Rotter J. R. C., Escalante T. D., Sosa F. E. E., Lozano F. F., Cervera L. F. F., Baron P. F., Ballesteros C. G., Rangel J. D. G., Jimenez L. E. H., Santana S. S. I., Flores F. J., Molina H. L., Ceballos R. I. L., Del Campo Blanco B. M., Franco G. M., Loza O. T. M., Rocha C. M., Vera G. O., Castellanos R. O., Calcaneo J. P., Rosano M. A. R., Pattzi H. R., Guzman J. R., Joerg I. E. R., Sanchez S. B. S., Mijangos J. H. S., Sanson P. S., Tamayo Y Orozco J. A., Chavez E. T., Cepeda A. V., Carrillo L. V., Mesa J. V., Escobedo R. Z., Baker J., Noonan P., Scott R., Walker R., Watson E., Williams M., Young S., Abejuela Z., Agra J., Aquitania G., Caringal C., Comia R. S., Santos L. D., Gomez O., Jimeno C., Santos F., Tan G., Tolentino M., Yao C., Yap Y. E., Ygpuara M. D. L., Bijata-Bronisz R., Hotlos L., Januszewicz A., Kaczmarek B., Kaminska A., Lazuka L., Madej A., Mazur S., Mlodawska-Choluj D., Nowicki M., Orlowska-Kowalik G., Popenda G., Rewerska B., Sowinski D., Angelescu L. M., Anghel V., Avram R. -I., Busegeanu M. -M., Cif A., Cosma D., Crisan C., Demian L. D., Ferariu I. E., Halmagyi I., Hancu N., Munteanu M., Negru D., Onaca A. G., Petrica L., Popa A. R., Ranetti A. -E., Serafinceanu C., Toarba C., Agafyina A., Barbarash O., Barysheva O., Chizhov D., Dobronravov V., Dreval A., Glinkina I., Grineva E., Khirmanov V., Kolmakova E., Koroleva T., Kvitkova L., Marasaev V., Mkrtumyan A., Morugova T., Nagibovich G., Nagibovich O., Nedogoda S., Osipova I., Raskina T., Samoylova Y., Sazonova O., Shamkhalova M., Shutemova E., Shwartz Y., Uriasyev O., Vorobyev S., Zateyshchikova A., Zateyshshikov D., Zykova T., Antic S., Djordjevic M., Kendereski A., Lalic K., Lalic N., Popovic-Radinovic V., Babikova J., Benusova O., Buganova I., Culak J., Dzupina A., Dzuponova J., Fulop P., Ilavska A., Martinka E., Ochodnicka Z., Pella D., Smatanova I., Ahmed F., Badat A., Breedt J., Distiller L., Govender V., Govender R., Joshi M., Jurgens J., Latiff G., Lombard L., Mookadam M., Ngcakani N., Nortje H., Oosthuizen H., Pillay-Ramaya L., Prozesky H., Reddy J., Rheeder P., Seeber M., Chae D. -W., Cho Y. M., Jeong I. -K., Kim S. G., Kim Y. H., Kwon H. -S., Kwon M. J., Lee B. -W., Lee J., Lee M. -K., Nam M. -S., Oh K. -H., Park C. -Y., Park S. -H., Yoon K. H., Garcia P. A., Mercadal L. A., Barrios C., Castro F. C., Guldris S. C., Lopez M. D., De Los Rios J. E., Fresnedo G. F., Serrano A. G., Garcia I., Martinez F. J. G., Gimeno J. E. J., Mendoza M. L., Marin T. M., Portillo C. M., Vila M. A. M., Torres M. M., Iglesias J. N., Perez J. P., Vera M. P., Perez J. M. P., Simon M. A. Q., Canonge R. S., Gonzalez A. S., Riera M. T., Madueno F. J. T., Plaza M. V., Chang C. -T., Chuang L. -M., Hsia T. -L., Hsieh C. -H., Hwang S. -J., Lin C. -C., Lu Y. -C., Sheu W. H. -H., Barna O., Bilyk S. 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J., Li Q., Neuen B. L., Cannon C. P., De Zeeuw D., Edwards R., Levin A., Mahaffey K. W., Perkovic V., Neal B., Lindley R. I., Guerrero R. A. A., Aizenberg D., Albisu J. P., Alvarisqueta A., Bartolacci I., Berli M. A., Bordonava A., Calella P., Cantero M. C., Cartasegna L. R., Cercos E., Coloma G. C., Colombo H., Commendatore V., Cuadrado J., Cuneo C. A., Cusumano A. M., Douthat W. G., Dran R. D., Farias E., Fernandez M. F., Finkelstein H., Fragale G., Fretes J. O., Garcia N. H., Gastaldi A., Gelersztein E., Glenny J. A., Gonzalez J. P., Del Carmen Gonzalez Colaso P., Goycoa C., Greloni G. C., Guinsburg A., Hermida S., Juncos L. I., Klyver M. I., Kraft F., Krynski F., Lanchiotti P. V., De La Fuente R. A. L., Marchetta N., Mele P., Nicolai S., Novoa P. A., Orio S. I., Otreras F., Oviedo A., Raffaele P., Resk J. H., Rista L., Papini N. R., Sala J., Santos J. C., Schiavi L. B., Sessa H., Casabella T. S., Ulla M. R., Valdez M., Vallejos A., Villarino A., Visco V. E., Wassermann A., Zaidman C. J., Cheung N. W., Droste C., Fraser I., Johnson D., Mah P. M., Nicholls K., Packham D., Proietto J., Roberts A., Roger S., Tsang V., Raduan R. A., Da Costa F. A. A., Amodeo C., Turatti L. A. A., Bregman R., Sanches F. C. C., Canani L. H., Chacra A. R., Borges J. L. C., Vencio S. A. C., Da Silva Franco R. J., D'Avila D., De Souza Portes E., De Souza P., Deboni L. M., Filho F. F., Neto B. G., Gomes M., Kohara S. K., Keitel E., Saraiva J. F. K., Lisboa H. R. K., De Carvalho Contieri F. L., Milagres R., Junior R. M., De Brito C. M., Hissa M. N., Sabbag A. R. N., Noronha I., Panarotto D., Filho R. P., Pereira M. A., Saporito W., Scotton A. S., Schuch T., De Almeida R. S., Ramos C. S., Felicio J. S., Thome F., Hachmann J. C. T., Yamada S., Hayashida C. Y., Petry T. B. Z., Zanella M. T., Andreeva V., Angelova A., Dimitrov S., Genadieva V., Genova-Hristova G., Hristozov K., Kamenov Z., Koundurdjiev A., Lozanov L., Margaritov V., Nonchev B., Rangelov R., Shinkov A., Temelkova M., Velichkova E., Yakov A., Aggarwal N., Aronson R., Bajaj H., Cherney D., Chouinard G., Conway J., Cournoyer S., DaRoza G., De Serres S., Dube F., Goldenberg R., Gupta A., Gupta M., Henein S., Khandwala H., Leiter L., Madore F., Mc-Mahon A., Muirhead N., Pichette V., Rabasa-Lhoret R., Steele A., Tangri N., Torshizi A., Woo V., Zalunardo N., Montenegro M. A. F., Jorquera J. G. G., Farina M. M., Gajardo V. S., Vejar M., Chen N., Chen Q., Gan S., Kong Y., Li D., Li W., Li X., Lin H., Liu J., Lu W., Mao H., Ren Y., Song W., Sun J., Sun L., Tu P., Wang G., Yang J., Yin A., Yu X., Zhao M., Zheng H., Mendoza J. L. A., Arcos E., Avendano J., Ruiz J. E. A. D., Ortiz L. H. G., Gonzalez A., Triana E. H., Higuera J. D., Malaver N., De Salazar D. I. M., Rosero R., Lozano M. A. T., Cometa L. V., Valenzuela A., Alonso R. D. V., Villegas I., Yupanqui H., Bartaskova D., Barton P., Belobradkova J., Dohnalova L., Drasnar T., Ferkl R., Halciakova K., Klokocnikova V., Kovar R., Lastuvka J., Lukac M., Pesickova S., Peterka K., Pumprla J., Rychlik I., Saudek F., Tesar V., Valis M., Weiner P., Zemek S., Alamartine E., Borot S., Cariou B., Dussol B., Fauvel J. -P., Gourdy P., Klein A., Le Meur Y., Penfornis A., Roussel R., Saulnier P. -J., Thervet E., Zaoui P., Burst V., Faghih M., Faulmann G., Haller H., Jerwan-Keim R., Maxeiner S., Paschen B., Plassmann G., Rose L., Orellana R. A. G., Haase F. P., Diaz J. P. M., Roca L. A. R., Arenales J. A. S., Polo J. V. S., Juarez E. T., Csecsei G., Csiky B., Danos P., Deak L., Dudas M., Harcsa E., Keltai K., Keresztesi S., Kiss K., Konyves L., Major L., Mileder M., Molnar M., Mucsi J., Oroszlan T., Ory I., Paragh G., Peterfai E., Petro G., Revesz K., Takacs R., Vangel S., Vasas S., Zsom M., Oomman A., Raju S. B., Dewan D., Fernando M. E., Gopalakrishnan N., Gracious N., Alva H., Jain D., Keshavamurthy C. B., Khullar D., Sahay M., Peringat J., Prasad N., Rao K. S., Reddy S., Melemadathil S., Sudhakar B., Vyasam R. C., Bonadonna R., Castellino P., Ceriello A., Chiovato L., De Cosmo S., De Nicola L., Derosa G., Carlo A. D., Cianni G. D., Frasca G., Fuiano G., Gambaro G., Garibotto G., Giorda C., Malberti F., Mandreoli M., Mannucci E., Orsi E., Piatti P., Santoro D., Sasso F. C., Serviddio G., Stella A., Trevisan R., Veronelli A. M., Zanoli L., Akiyama H., Aoki H., Asano A., Iitsuka T., Kajiyama S., Kashine S., Kawada T., Kodera T., Kono H., Koyama K., Kumeda Y., Miyauchi S., Mizuyama K., Niiya T., Oishi H., Ota S., Sakakibara T., Takai M., Tomonaga O., Tsujimoto M., Wada T., Wakasugi M., Wakida Y., Watanabe T., Yamada M., Yanagida K., Yanase T., Yumita W., Gaupsiene E., Kozloviene D., Navickas A., Urbanaviciene E., Ghani R. A., Kadir K. A., Ali N., Yusof M. D. C., Gan C. L., Ismail M., Kong W. Y., Lam S. W., Lee L. Y., Lim S. K., Loh C. L., Manocha A. B., Ng K. S., Ahmad N. N. F. N., Ratnasingam V., Shudim S. S. B., Vengadasalam P., Munoz L. D. A., Salazar M. A., Cruz J. B., Soto M. B., Ramos J. C., Wong A. C., Rotter J. R. C., Escalante T. D., Sosa F. E. E., Lozano F. F., Cervera L. F. F., Baron P. F., Ballesteros C. G., Rangel J. D. G., Jimenez L. E. H., Santana S. S. I., Flores F. J., Molina H. L., Ceballos R. I. L., Del Campo Blanco B. M., Franco G. M., Loza O. T. M., Rocha C. M., Vera G. O., Castellanos R. O., Calcaneo J. P., Rosano M. A. R., Pattzi H. R., Guzman J. R., Joerg I. E. R., Sanchez S. B. S., Mijangos J. H. S., Sanson P. S., Tamayo Y Orozco J. A., Chavez E. T., Cepeda A. V., Carrillo L. V., Mesa J. V., Escobedo R. Z., Baker J., Noonan P., Scott R., Walker R., Watson E., Williams M., Young S., Abejuela Z., Agra J., Aquitania G., Caringal C., Comia R. S., Santos L. D., Gomez O., Jimeno C., Santos F., Tan G., Tolentino M., Yao C., Yap Y. E., Ygpuara M. D. L., Bijata-Bronisz R., Hotlos L., Januszewicz A., Kaczmarek B., Kaminska A., Lazuka L., Madej A., Mazur S., Mlodawska-Choluj D., Nowicki M., Orlowska-Kowalik G., Popenda G., Rewerska B., Sowinski D., Angelescu L. M., Anghel V., Avram R. -I., Busegeanu M. -M., Cif A., Cosma D., Crisan C., Demian L. D., Ferariu I. E., Halmagyi I., Hancu N., Munteanu M., Negru D., Onaca A. G., Petrica L., Popa A. R., Ranetti A. -E., Serafinceanu C., Toarba C., Agafyina A., Barbarash O., Barysheva O., Chizhov D., Dobronravov V., Dreval A., Glinkina I., Grineva E., Khirmanov V., Kolmakova E., Koroleva T., Kvitkova L., Marasaev V., Mkrtumyan A., Morugova T., Nagibovich G., Nagibovich O., Nedogoda S., Osipova I., Raskina T., Samoylova Y., Sazonova O., Shamkhalova M., Shutemova E., Shwartz Y., Uriasyev O., Vorobyev S., Zateyshchikova A., Zateyshshikov D., Zykova T., Antic S., Djordjevic M., Kendereski A., Lalic K., Lalic N., Popovic-Radinovic V., Babikova J., Benusova O., Buganova I., Culak J., Dzupina A., Dzuponova J., Fulop P., Ilavska A., Martinka E., Ochodnicka Z., Pella D., Smatanova I., Ahmed F., Badat A., Breedt J., Distiller L., Govender V., Govender R., Joshi M., Jurgens J., Latiff G., Lombard L., Mookadam M., Ngcakani N., Nortje H., Oosthuizen H., Pillay-Ramaya L., Prozesky H., Reddy J., Rheeder P., Seeber M., Chae D. -W., Cho Y. M., Jeong I. -K., Kim S. G., Kim Y. H., Kwon H. -S., Kwon M. J., Lee B. -W., Lee J., Lee M. -K., Nam M. -S., Oh K. -H., Park C. -Y., Park S. -H., Yoon K. H., Garcia P. A., Mercadal L. A., Barrios C., Castro F. C., Guldris S. C., Lopez M. D., De Los Rios J. E., Fresnedo G. F., Serrano A. G., Garcia I., Martinez F. J. G., Gimeno J. E. J., Mendoza M. L., Marin T. M., Portillo C. M., Vila M. A. M., Torres M. M., Iglesias J. N., Perez J. P., Vera M. P., Perez J. M. P., Simon M. A. Q., Canonge R. S., Gonzalez A. S., Riera M. T., Madueno F. J. T., Plaza M. V., Chang C. -T., Chuang L. -M., Hsia T. -L., Hsieh C. -H., Hwang S. -J., Lin C. -C., Lu Y. -C., Sheu W. H. -H., Barna O., Bilyk S. D., Botsyurko V., Dudar I., Fushtey I., Godlevska O., Golovchenko O., Gyrina O., Kazmirchuk A., Kolesnyk M., Komisarenko I., Korzh O., Kravchun N., Legun O., Mankovskyy B., Martynyuk L., Mostovoy Y., Pashkovska N., Pererva L., Pertseva T., Samoylov O., Smirnov I., Svyshchenko Y., Tomashkevych H., Topchii I., Tryshchuk N., Tseluyko V., Vizir V., Vlasenko M., Zlova T., Zub L., Abusnana S., Railey M., Abouglila K., Ainsworth P., Ali Z., Arutchelvam V., Barnard M., Bellary S., Davies E., Davies M., Davies S., Dawson A., Kossi M. E., English P., Fraser D., Gnudi L., Gunstone A., Hall T., Hanif W., Jackson A., Johnson A., Joseph F., Krishnan S., Kumwenda M., MacDougall I., Nixon P., O'Hare J., Philip S., Ramtoola S., Saxena M., Sennik D., Simon G., Singh B., Stephens J., Strzelecka A., Symonds R., Turner W., Wahba M., Wakeling J., Wheeler D., Winocour P., Abdallah J., Abdullah R., Abramowitz M., Acosta I., Aiello J., Akright L., Akyea-Djamson A., Alappan R., Alicic R., Al-Karadsheh A., Allison D. C., Arauz-Pacheco C., Arfeen S., Arif A., Arvind M., Atray N., Awad A., Bakris G., Barnhill P., Barranco E., Barrera C., Beacom M., Behara V., Belo D., Bentley-Lewis R., Berenguer R., Bermudez L., Bernardo M., Biscoveanu M., Bowman-Stroud C., Brandon D., Brusco O., Busch R., Canaan Y., Chilito A., Christensen T., Christiano C., Christofides E., Chuateco C., Cohen K., Cohen R., Cohen-Stein D., Cook C., Coyne D., Daboul N., Darwish R., Daswani A., Deck K., Desouza C., Dev D., Dhillon M., Dua S., Eder F., Elosegui A. M., El-Shahawy M., Ervin J., Esquenazi A., Evans J., Fishbane S., Frias J., Galindo-Ramos E., Galphin C., Ghazi A., Gonzalez E., Gorson D., Gowda A., Greco B., Grubb S., Gulati R., Hammoud J., Handelsman S., Hartman I., Hershon K., Hiser D., Hon G., Jacob R., Jaime M., Jamal A., Kaupke C., Keightley G., Kern E., Khanna R., Khitan Z., Kim S., Kopyt N., Kovesdy C., Krishna G., Kropp J., Kumar A., Kumar J., Kumar N., Kusnir J., Lane W., Lawrence M., Lehrner L., Lentz J., Levinson D., Lewis D., Liss K., Maddux A., Maheshwari H., Mandayam S., Marar I., Mehta B., Middleton J., Mordujovich J., Moreda R., Moustafa M., Trenche S. M., Narayanan M., Narvarte J., Nassar T., Newman G., Nichol B., Nicol P., Nisnisan J., Nossuli A. K., Obialo C., Olelewe S., Oliver M., O'Shaughnessy A., Padron J., Pankhaniya R., Parker R., Patel D., Patel G., Patel N., Pavon H., Perez A., Perez C., Perlman A., Pettis K., Pharr W., Phillips A., Purighalla R., Quesada-Suarez L., Ranjan R., Rastogi S., Rendell M., Rich L., Robinson M., Rodriguez H., Rosas S., Saba F., Sankaram R., Sarin R., Schreiman R., Scott D., Sekkarie M., Sensenbrenner J., Shakeel M., Shanik M., Shaw S., Smith S., Solomon R., Sprague A., Spry L., Suchinda P., Sultan S., Surampudi P., Sussman S., Tan A., Terrelonge A., Thompson M., Trespalacios F., Trippe B., Trueba P., Twahirwa M., Updegrove J., Van Buren P., Vannorsdall M., Varghese F., Velasquez-Mieyer P., Ventrapragada S., Vukotic G., Wadud K., Warren M., Watson H., Watts R., Weiner D., Welker J., Welsh J., Williams S., and Zaniewski-Singh M.
- Abstract
BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-Analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-Analysis. RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: Total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]). CONCLUSIONS: Although we found no clear effect
- Published
- 2021
9. Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis
- Author
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Zhou Z., Jardine M. J., Li Q., Neuen B. L., Cannon C. P., De Zeeuw D., Edwards R., Levin A., Mahaffey K. W., Perkovic V., Neal B., Lindley R. I., Guerrero R. A. A., Aizenberg D., Albisu J. P., Alvarisqueta A., Bartolacci I., Berli M. A., Bordonava A., Calella P., Cantero M. C., Cartasegna L. R., Cercos E., Coloma G. C., Colombo H., Commendatore V., Cuadrado J., Cuneo C. A., Cusumano A. M., Douthat W. G., Dran R. D., Farias E., Fernandez M. F., Finkelstein H., Fragale G., Fretes J. O., Garcia N. H., Gastaldi A., Gelersztein E., Glenny J. A., Gonzalez J. P., Del Carmen Gonzalez Colaso P., Goycoa C., Greloni G. C., Guinsburg A., Hermida S., Juncos L. I., Klyver M. I., Kraft F., Krynski F., Lanchiotti P. V., De La Fuente R. A. L., Marchetta N., Mele P., Nicolai S., Novoa P. A., Orio S. I., Otreras F., Oviedo A., Raffaele P., Resk J. H., Rista L., Papini N. R., Sala J., Santos J. C., Schiavi L. B., Sessa H., Casabella T. S., Ulla M. R., Valdez M., Vallejos A., Villarino A., Visco V. E., Wassermann A., Zaidman C. J., Cheung N. W., Droste C., Fraser I., Johnson D., Mah P. M., Nicholls K., Packham D., Proietto J., Roberts A., Roger S., Tsang V., Raduan R. A., Da Costa F. A. A., Amodeo C., Turatti L. A. A., Bregman R., Sanches F. C. C., Canani L. H., Chacra A. R., Borges J. L. C., Vencio S. A. C., Da Silva Franco R. J., D'Avila D., De Souza Portes E., De Souza P., Deboni L. M., Filho F. F., Neto B. G., Gomes M., Kohara S. K., Keitel E., Saraiva J. F. K., Lisboa H. R. K., De Carvalho Contieri F. L., Milagres R., Junior R. M., De Brito C. M., Hissa M. N., Sabbag A. R. N., Noronha I., Panarotto D., Filho R. P., Pereira M. A., Saporito W., Scotton A. S., Schuch T., De Almeida R. S., Ramos C. S., Felicio J. S., Thome F., Hachmann J. C. T., Yamada S., Hayashida C. Y., Petry T. B. Z., Zanella M. T., Andreeva V., Angelova A., Dimitrov S., Genadieva V., Genova-Hristova G., Hristozov K., Kamenov Z., Koundurdjiev A., Lozanov L., Margaritov V., Nonchev B., Rangelov R., Shinkov A., Temelkova M., Velichkova E., Yakov A., Aggarwal N., Aronson R., Bajaj H., Cherney D., Chouinard G., Conway J., Cournoyer S., DaRoza G., De Serres S., Dube F., Goldenberg R., Gupta A., Gupta M., Henein S., Khandwala H., Leiter L., Madore F., Mc-Mahon A., Muirhead N., Pichette V., Rabasa-Lhoret R., Steele A., Tangri N., Torshizi A., Woo V., Zalunardo N., Montenegro M. A. F., Jorquera J. G. G., Farina M. M., Gajardo V. S., Vejar M., Chen N., Chen Q., Gan S., Kong Y., Li D., Li W., Li X., Lin H., Liu J., Lu W., Mao H., Ren Y., Song W., Sun J., Sun L., Tu P., Wang G., Yang J., Yin A., Yu X., Zhao M., Zheng H., Mendoza J. L. A., Arcos E., Avendano J., Ruiz J. E. A. D., Ortiz L. H. G., Gonzalez A., Triana E. H., Higuera J. D., Malaver N., De Salazar D. I. M., Rosero R., Lozano M. A. T., Cometa L. V., Valenzuela A., Alonso R. D. V., Villegas I., Yupanqui H., Bartaskova D., Barton P., Belobradkova J., Dohnalova L., Drasnar T., Ferkl R., Halciakova K., Klokocnikova V., Kovar R., Lastuvka J., Lukac M., Pesickova S., Peterka K., Pumprla J., Rychlik I., Saudek F., Tesar V., Valis M., Weiner P., Zemek S., Alamartine E., Borot S., Cariou B., Dussol B., Fauvel J. -P., Gourdy P., Klein A., Le Meur Y., Penfornis A., Roussel R., Saulnier P. -J., Thervet E., Zaoui P., Burst V., Faghih M., Faulmann G., Haller H., Jerwan-Keim R., Maxeiner S., Paschen B., Plassmann G., Rose L., Orellana R. A. G., Haase F. P., Diaz J. P. M., Roca L. A. R., Arenales J. A. S., Polo J. V. S., Juarez E. T., Csecsei G., Csiky B., Danos P., Deak L., Dudas M., Harcsa E., Keltai K., Keresztesi S., Kiss K., Konyves L., Major L., Mileder M., Molnar M., Mucsi J., Oroszlan T., Ory I., Paragh G., Peterfai E., Petro G., Revesz K., Takacs R., Vangel S., Vasas S., Zsom M., Oomman A., Raju S. B., Dewan D., Fernando M. E., Gopalakrishnan N., Gracious N., Alva H., Jain D., Keshavamurthy C. B., Khullar D., Sahay M., Peringat J., Prasad N., Rao K. S., Reddy S., Melemadathil S., Sudhakar B., Vyasam R. C., Bonadonna R., Castellino P., Ceriello A., Chiovato L., De Cosmo S., De Nicola L., Derosa G., Carlo A. D., Cianni G. D., Frasca G., Fuiano G., Gambaro G., Garibotto G., Giorda C., Malberti F., Mandreoli M., Mannucci E., Orsi E., Piatti P., Santoro D., Sasso F. C., Serviddio G., Stella A., Trevisan R., Veronelli A. M., Zanoli L., Akiyama H., Aoki H., Asano A., Iitsuka T., Kajiyama S., Kashine S., Kawada T., Kodera T., Kono H., Koyama K., Kumeda Y., Miyauchi S., Mizuyama K., Niiya T., Oishi H., Ota S., Sakakibara T., Takai M., Tomonaga O., Tsujimoto M., Wada T., Wakasugi M., Wakida Y., Watanabe T., Yamada M., Yanagida K., Yanase T., Yumita W., Gaupsiene E., Kozloviene D., Navickas A., Urbanaviciene E., Ghani R. A., Kadir K. A., Ali N., Yusof M. D. C., Gan C. L., Ismail M., Kong W. Y., Lam S. W., Lee L. 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E., English P., Fraser D., Gnudi L., Gunstone A., Hall T., Hanif W., Jackson A., Johnson A., Joseph F., Krishnan S., Kumwenda M., MacDougall I., Nixon P., O'Hare J., Philip S., Ramtoola S., Saxena M., Sennik D., Simon G., Singh B., Stephens J., Strzelecka A., Symonds R., Turner W., Wahba M., Wakeling J., Wheeler D., Winocour P., Abdallah J., Abdullah R., Abramowitz M., Acosta I., Aiello J., Akright L., Akyea-Djamson A., Alappan R., Alicic R., Al-Karadsheh A., Allison D. C., Arauz-Pacheco C., Arfeen S., Arif A., Arvind M., Atray N., Awad A., Bakris G., Barnhill P., Barranco E., Barrera C., Beacom M., Behara V., Belo D., Bentley-Lewis R., Berenguer R., Bermudez L., Bernardo M., Biscoveanu M., Bowman-Stroud C., Brandon D., Brusco O., Busch R., Canaan Y., Chilito A., Christensen T., Christiano C., Christofides E., Chuateco C., Cohen K., Cohen R., Cohen-Stein D., Cook C., Coyne D., Daboul N., Darwish R., Daswani A., Deck K., Desouza C., Dev D., Dhillon M., Dua S., Eder F., Elosegui A. M., El-Shahawy M., Ervin J., Esquenazi A., Evans J., Fishbane S., Frias J., Galindo-Ramos E., Galphin C., Ghazi A., Gonzalez E., Gorson D., Gowda A., Greco B., Grubb S., Gulati R., Hammoud J., Handelsman S., Hartman I., Hershon K., Hiser D., Hon G., Jacob R., Jaime M., Jamal A., Kaupke C., Keightley G., Kern E., Khanna R., Khitan Z., Kim S., Kopyt N., Kovesdy C., Krishna G., Kropp J., Kumar A., Kumar J., Kumar N., Kusnir J., Lane W., Lawrence M., Lehrner L., Lentz J., Levinson D., Lewis D., Liss K., Maddux A., Maheshwari H., Mandayam S., Marar I., Mehta B., Middleton J., Mordujovich J., Moreda R., Moustafa M., Trenche S. M., Narayanan M., Narvarte J., Nassar T., Newman G., Nichol B., Nicol P., Nisnisan J., Nossuli A. 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M., Nicholls, K., Packham, D., Proietto, J., Roberts, A., Roger, S., Tsang, V., Raduan, R. A., Da Costa, F. A. A., Amodeo, C., Turatti, L. A. A., Bregman, R., Sanches, F. C. C., Canani, L. H., Chacra, A. R., Borges, J. L. C., Vencio, S. A. C., Da Silva Franco, R. J., D'Avila, D., De Souza Portes, E., De Souza, P., Deboni, L. M., Filho, F. F., Neto, B. G., Gomes, M., Kohara, S. K., Keitel, E., Saraiva, J. F. K., Lisboa, H. R. K., De Carvalho Contieri, F. L., Milagres, R., Junior, R. M., De Brito, C. M., Hissa, M. N., Sabbag, A. R. N., Noronha, I., Panarotto, D., Filho, R. P., Pereira, M. A., Saporito, W., Scotton, A. S., Schuch, T., De Almeida, R. S., Ramos, C. S., Felicio, J. S., Thome, F., Hachmann, J. C. T., Yamada, S., Hayashida, C. Y., Petry, T. B. Z., Zanella, M. 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E., English, P., Fraser, D., Gnudi, L., Gunstone, A., Hall, T., Hanif, W., Jackson, A., Johnson, A., Joseph, F., Krishnan, S., Kumwenda, M., Macdougall, I., Nixon, P., O'Hare, J., Philip, S., Ramtoola, S., Saxena, M., Sennik, D., Simon, G., Singh, B., Stephens, J., Strzelecka, A., Symonds, R., Turner, W., Wahba, M., Wakeling, J., Wheeler, D., Winocour, P., Abdallah, J., Abdullah, R., Abramowitz, M., Acosta, I., Aiello, J., Akright, L., Akyea-Djamson, A., Alappan, R., Alicic, R., Al-Karadsheh, A., Allison, D. C., Arauz-Pacheco, C., Arfeen, S., Arif, A., Arvind, M., Atray, N., Awad, A., Bakris, G., Barnhill, P., Barranco, E., Barrera, C., Beacom, M., Behara, V., Belo, D., Bentley-Lewis, R., Berenguer, R., Bermudez, L., Bernardo, M., Biscoveanu, M., Bowman-Stroud, C., Brandon, D., Brusco, O., Busch, R., Canaan, Y., Chilito, A., Christensen, T., Christiano, C., Christofides, E., Chuateco, C., Cohen, K., Cohen, R., Cohen-Stein, D., Cook, C., Coyne, D., Daboul, N., Darwish, R., Daswani, A., Deck, K., Desouza, C., Dev, D., Dhillon, M., Dua, S., Eder, F., Elosegui, A. M., El-Shahawy, M., Ervin, J., Esquenazi, A., Evans, J., Fishbane, S., Frias, J., Galindo-Ramos, E., Galphin, C., Ghazi, A., Gonzalez, E., Gorson, D., Gowda, A., Greco, B., Grubb, S., Gulati, R., Hammoud, J., Handelsman, S., Hartman, I., Hershon, K., Hiser, D., Hon, G., Jacob, R., Jaime, M., Jamal, A., Kaupke, C., Keightley, G., Kern, E., Khanna, R., Khitan, Z., Kim, S., Kopyt, N., Kovesdy, C., Krishna, G., Kropp, J., Kumar, A., Kumar, J., Kumar, N., Kusnir, J., Lane, W., Lawrence, M., Lehrner, L., Lentz, J., Levinson, D., Lewis, D., Liss, K., Maddux, A., Maheshwari, H., Mandayam, S., Marar, I., Mehta, B., Middleton, J., Mordujovich, J., Moreda, R., Moustafa, M., Trenche, S. M., Narayanan, M., Narvarte, J., Nassar, T., Newman, G., Nichol, B., Nicol, P., Nisnisan, J., Nossuli, A. K., Obialo, C., Olelewe, S., Oliver, M., O'Shaughnessy, A., Padron, J., Pankhaniya, R., Parker, R., Patel, D., Patel, G., Patel, N., Pavon, H., Perez, A., Perez, C., Perlman, A., Pettis, K., Pharr, W., Phillips, A., Purighalla, R., Quesada-Suarez, L., Ranjan, R., Rastogi, S., Rendell, M., Rich, L., Robinson, M., Rodriguez, H., Rosas, S., Saba, F., Sankaram, R., Sarin, R., Schreiman, R., Scott, D., Sekkarie, M., Sensenbrenner, J., Shakeel, M., Shanik, M., Shaw, S., Smith, S., Solomon, R., Sprague, A., Spry, L., Suchinda, P., Sultan, S., Surampudi, P., Sussman, S., Tan, A., Terrelonge, A., Thompson, M., Trespalacios, F., Trippe, B., Trueba, P., Twahirwa, M., Updegrove, J., Van Buren, P., Vannorsdall, M., Varghese, F., Velasquez-Mieyer, P., Ventrapragada, S., Vukotic, G., Wadud, K., Warren, M., Watson, H., Watts, R., Weiner, D., Welker, J., Welsh, J., Williams, S., Zaniewski-Singh, M., Groningen Kidney Center (GKC), Zhou, Z, Jardine, M, Li, Q, Neuen, B, Cannon, C, De Zeeuw, D, Edwards, R, 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Haase, F, Diaz, J, Roca, L, Arenales, J, Polo, J, Juarez, E, Csecsei, G, Csiky, B, Danos, P, Deak, L, Dudas, M, Harcsa, E, Keltai, K, Keresztesi, S, Kiss, K, Konyves, L, Major, L, Mileder, M, Molnar, M, Mucsi, J, Oroszlan, T, Ory, I, Paragh, G, Peterfai, E, Petro, G, Revesz, K, Takacs, R, Vangel, S, Vasas, S, Zsom, M, Oomman, A, Raju, S, Dewan, D, Fernando, M, Gopalakrishnan, N, Gracious, N, Alva, H, Jain, D, Keshavamurthy, C, Khullar, D, Sahay, M, Peringat, J, Prasad, N, Rao, K, Reddy, S, Melemadathil, S, Sudhakar, B, Vyasam, R, Bonadonna, R, Castellino, P, Ceriello, A, Chiovato, L, De Cosmo, S, De Nicola, L, Derosa, G, Carlo, A, Cianni, G, Frasca, G, Fuiano, G, Gambaro, G, Garibotto, G, Giorda, C, Malberti, F, Mandreoli, M, Mannucci, E, Orsi, E, Piatti, P, Santoro, D, Sasso, F, Serviddio, G, Stella, A, Trevisan, R, Veronelli, A, Zanoli, L, Akiyama, H, Aoki, H, Asano, A, Iitsuka, T, Kajiyama, S, Kashine, S, Kawada, T, Kodera, T, Kono, H, Koyama, K, Kumeda, Y, Miyauchi, S, Mizuyama, K, Niiya, T, Oishi, H, Ota, S, Sakakibara, T, Takai, M, Tomonaga, O, Tsujimoto, M, Wada, T, Wakasugi, M, Wakida, Y, Watanabe, T, Yamada, M, Yanagida, K, Yanase, T, Yumita, W, Gaupsiene, E, Kozloviene, D, Navickas, A, Urbanaviciene, E, Ghani, R, Kadir, K, Ali, N, Yusof, M, Gan, C, Ismail, M, Kong, W, Lam, S, Lee, L, Lim, S, Loh, C, Manocha, A, Ng, K, Ahmad, N, Ratnasingam, V, Shudim, S, Vengadasalam, P, Munoz, L, Salazar, M, Cruz, J, Soto, M, Ramos, J, Wong, A, Rotter, J, Escalante, T, Sosa, F, Lozano, F, Cervera, L, Baron, P, Ballesteros, C, Rangel, J, Jimenez, L, Santana, S, Flores, F, Molina, H, Ceballos, R, Del Campo Blanco, B, Franco, G, Loza, O, Rocha, C, Vera, G, Castellanos, R, Calcaneo, J, Rosano, M, Pattzi, H, Guzman, J, Joerg, I, Sanchez, S, Mijangos, J, Sanson, P, Tamayo Y Orozco, J, Chavez, E, Cepeda, A, Carrillo, L, Mesa, J, Escobedo, R, Baker, J, Noonan, P, Scott, R, Walker, R, Watson, E, Williams, M, Young, S, Abejuela, Z, Agra, J, Aquitania, G, Caringal, C, Comia, R, Santos, L, Gomez, O, Jimeno, C, Santos, F, Tan, G, Tolentino, M, Yao, C, Yap, Y, Ygpuara, M, Bijata-Bronisz, R, Hotlos, L, Januszewicz, A, Kaczmarek, B, Kaminska, A, Lazuka, L, Madej, A, Mazur, S, Mlodawska-Choluj, D, Nowicki, M, Orlowska-Kowalik, G, Popenda, G, Rewerska, B, Sowinski, D, Angelescu, L, Anghel, V, Avram, R, Busegeanu, M, Cif, A, Cosma, D, Crisan, C, Demian, L, Ferariu, I, Halmagyi, I, Hancu, N, Munteanu, M, Negru, D, Onaca, A, Petrica, L, Popa, A, Ranetti, A, Serafinceanu, C, Toarba, C, Agafyina, A, Barbarash, O, Barysheva, O, Chizhov, D, Dobronravov, V, Dreval, A, Glinkina, I, Grineva, E, Khirmanov, V, Kolmakova, E, Koroleva, T, Kvitkova, L, Marasaev, V, Mkrtumyan, A, Morugova, T, Nagibovich, G, Nagibovich, O, Nedogoda, S, Osipova, I, Raskina, T, Samoylova, Y, Sazonova, O, Shamkhalova, M, Shutemova, E, Shwartz, Y, Uriasyev, O, Vorobyev, S, Zateyshchikova, A, Zateyshshikov, D, Zykova, T, Antic, S, Djordjevic, M, Kendereski, A, Lalic, K, Lalic, N, Popovic-Radinovic, V, Babikova, J, Benusova, O, Buganova, I, Culak, J, Dzupina, A, Dzuponova, J, Fulop, P, Ilavska, A, Martinka, E, Ochodnicka, Z, Pella, D, Smatanova, I, Ahmed, F, Badat, A, Breedt, J, Distiller, L, Govender, V, Govender, R, Joshi, M, Jurgens, J, Latiff, G, Lombard, L, Mookadam, M, Ngcakani, N, Nortje, H, Oosthuizen, H, Pillay-Ramaya, L, Prozesky, H, Reddy, J, Rheeder, P, Seeber, M, Chae, D, Cho, Y, Jeong, I, Kim, S, Kim, Y, Kwon, H, Kwon, M, Lee, B, Lee, J, Lee, M, Nam, M, Oh, K, Park, C, Park, S, Yoon, K, Garcia, P, Mercadal, L, Barrios, C, Castro, F, Guldris, S, Lopez, M, De Los Rios, J, Fresnedo, G, Serrano, A, Garcia, I, Martinez, F, Gimeno, J, Mendoza, M, Marin, T, Portillo, C, Vila, M, Torres, M, Iglesias, J, Perez, J, Vera, M, Simon, M, Canonge, R, Riera, M, Madueno, F, Plaza, M, Chang, C, Chuang, L, Hsia, T, Hsieh, C, Hwang, S, Lin, C, Lu, Y, Sheu, W, Barna, O, Bilyk, S, Botsyurko, V, Dudar, I, Fushtey, I, Godlevska, O, Golovchenko, O, Gyrina, O, Kazmirchuk, A, Kolesnyk, M, Komisarenko, I, Korzh, O, Kravchun, N, Legun, O, Mankovskyy, B, Martynyuk, L, Mostovoy, Y, Pashkovska, N, Pererva, L, Pertseva, T, Samoylov, O, Smirnov, I, Svyshchenko, Y, Tomashkevych, H, Topchii, I, Tryshchuk, N, Tseluyko, V, Vizir, V, Vlasenko, M, Zlova, T, Zub, L, Abusnana, S, Railey, M, Abouglila, K, Ainsworth, P, Ali, Z, Arutchelvam, V, Barnard, M, Bellary, S, Davies, E, Davies, M, Davies, S, Dawson, A, Kossi, M, English, P, Fraser, D, Gnudi, L, Gunstone, A, Hall, T, Hanif, W, Jackson, A, Johnson, A, Joseph, F, Krishnan, S, Kumwenda, M, Macdougall, I, Nixon, P, O'Hare, J, Philip, S, Ramtoola, S, Saxena, M, Sennik, D, Simon, G, Singh, B, Stephens, J, Strzelecka, A, Symonds, R, Turner, W, Wahba, M, Wakeling, J, Wheeler, D, Winocour, P, Abdallah, J, Abdullah, R, Abramowitz, M, Acosta, I, Aiello, J, Akright, L, Akyea-Djamson, A, Alappan, R, Alicic, R, Al-Karadsheh, A, Allison, D, Arauz-Pacheco, C, Arfeen, S, Arif, A, Arvind, M, Atray, N, Awad, A, Bakris, G, Barnhill, P, Barranco, E, Barrera, C, Beacom, M, Behara, V, Belo, D, Bentley-Lewis, R, Berenguer, R, Bermudez, L, Bernardo, M, Biscoveanu, M, Bowman-Stroud, C, Brandon, D, Brusco, O, Busch, R, Canaan, Y, Chilito, A, Christensen, T, Christiano, C, Christofides, E, Chuateco, C, Cohen, K, Cohen, R, Cohen-Stein, D, Cook, C, Coyne, D, Daboul, N, Darwish, R, Daswani, A, Deck, K, Desouza, C, Dev, D, Dhillon, M, Dua, S, Eder, F, Elosegui, A, El-Shahawy, M, Ervin, J, Esquenazi, A, Evans, J, Fishbane, S, Frias, J, Galindo-Ramos, E, Galphin, C, Ghazi, A, Gonzalez, E, Gorson, D, Gowda, A, Greco, B, Grubb, S, Gulati, R, Hammoud, J, Handelsman, S, Hartman, I, Hershon, K, Hiser, D, Hon, G, Jacob, R, Jaime, M, Jamal, A, Kaupke, C, Keightley, G, Kern, E, Khanna, R, Khitan, Z, Kopyt, N, Kovesdy, C, Krishna, G, Kropp, J, Kumar, A, Kumar, J, Kumar, N, Kusnir, J, Lane, W, Lawrence, M, Lehrner, L, Lentz, J, Levinson, D, Lewis, D, Liss, K, Maddux, A, Maheshwari, H, Mandayam, S, Marar, I, Mehta, B, Middleton, J, Mordujovich, J, Moreda, R, Moustafa, M, Trenche, S, Narayanan, M, Narvarte, J, Nassar, T, Newman, G, Nichol, B, Nicol, P, Nisnisan, J, Nossuli, A, Obialo, C, Olelewe, S, Oliver, M, O'Shaughnessy, A, Padron, J, Pankhaniya, R, Parker, R, Patel, D, Patel, G, Patel, N, Pavon, H, Perez, A, Perez, C, Perlman, A, Pettis, K, Pharr, W, Phillips, A, Purighalla, R, Quesada-Suarez, L, Ranjan, R, Rastogi, S, Rendell, M, Rich, L, Robinson, M, Rodriguez, H, Rosas, S, Saba, F, Sankaram, R, Sarin, R, Schreiman, R, Scott, D, Sekkarie, M, Sensenbrenner, J, Shakeel, M, Shanik, M, Shaw, S, Smith, S, Solomon, R, Sprague, A, Spry, L, Suchinda, P, Sultan, S, Surampudi, P, Sussman, S, Tan, A, Terrelonge, A, Thompson, M, Trespalacios, F, Trippe, B, Trueba, P, Twahirwa, M, Updegrove, J, Van Buren, P, Vannorsdall, M, Varghese, F, Velasquez-Mieyer, P, Ventrapragada, S, Vukotic, G, Wadud, K, Warren, M, Watson, H, Watts, R, Weiner, D, Welker, J, Welsh, J, Williams, S, and Zaniewski-Singh, M
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medicine.medical_specialty ,Original Contributions ,atrial fibrillation ,canagliflozin ,glomerular filtration rate ,hemorrhagic stroke ,ischemic stroke ,Renal function ,Disease ,Brain Ischemia ,Clinical and Population Sciences ,Meta-Analysis as Topic ,Internal medicine ,CREDENCE Trial Investigators ,Atrial Fibrillation ,medicine ,Diabetes Mellitus ,Humans ,Diabetic Nephropathies ,Canagliflozin ,Stroke ,1102 Cardiorespiratory Medicine and Haematology ,Sodium-Glucose Transporter 2 Inhibitors ,Advanced and Specialized Nursing ,Neurology & Neurosurgery ,business.industry ,Atrial fibrillation ,1103 Clinical Sciences ,medicine.disease ,Diabetes Mellitus, Type 2 ,Meta-analysis ,Cardiology ,Albuminuria ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Neurology (clinical) ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,1109 Neurosciences ,Kidney disease ,medicine.drug - Abstract
Supplemental Digital Content is available in the text., Background and Purpose: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. Methods: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis. Results: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55–1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61–1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19–1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20–1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53–1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82–1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89–1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30–0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49–1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71–0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (
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- 2021
10. Outcome of treatment of MDR-TB or drug-resistant patients treated with bedaquiline and delamanid: Results from a large global cohort
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Koirala, S, Borisov, S, Danila, E, Mariandyshev, A, Shrestha, B, Lukhele, N, Dalcolmo, M, Shakya, SR, Miliauskas, S, Kuksa, L, Manga, S, Aleksa, A, Denholm, JT, Khadka, HB, Skrahina, A, Diktanas, S, Ferrarese, M, Bruchfeld, J, Koleva, A, Piubello, A, Koirala, GS, Udwadia, ZF, Palmero, DJ, Munoz-Torrico, M, Gc, R, Gualano, G, Grecu, V, Motta, I, Papavasileiou, A, Li, Y, Hoefsloot, W, Kunst, H, Mazza-Stalder, J, Payen, M-C, Akkerman, OW, Bernal, E, Manfrin, V, Matteelli, A, Hamdan, HM, Marcos, MN, Cadinanos Loidi, J, Cebrian Gallardo, JJ, Duarte, R, Escobar Salinas, N, Gomez Rosso, R, Laniado-Laborin, R, Martinez Robles, E, Quiros Fernandez, S, Rendon, A, Solovic, I, Tadolini, M, Viggiani, P, Belilovski, E, Boeree, MJ, Cai, Q, Davidaviciene, E, Forsman, LD, De Los Rios, J, Draksiene, J, Duga, A, Elamin, SE, Filippov, A, Garcia, A, Gaudiesiute, I, Gavazova, B, Gayoso, R, Gruslys, V, Jonsson, J, Khimova, E, Madonsela, G, Magis-Escurra, C, Marchese, V, Matei, M, Moschos, C, Nakceriene, B, Nicod, L, Palmieri, F, Pontarelli, A, Smite, A, Souleymane, MB, Vescovo, M, Zablockis, R, Zhurkin, D, Alffenaar, J-W, Caminero, JA, Codecasa, LR, Garcia-Garcia, J-M, Esposito, S, Saderi, L, Spanevello, A, Visca, D, Tiberi, S, Pontali, E, Centis, R, D'Ambrosio, L, van den Boom, M, Sotgiuw, G, Migliori, GB, Koirala, S, Borisov, S, Danila, E, Mariandyshev, A, Shrestha, B, Lukhele, N, Dalcolmo, M, Shakya, SR, Miliauskas, S, Kuksa, L, Manga, S, Aleksa, A, Denholm, JT, Khadka, HB, Skrahina, A, Diktanas, S, Ferrarese, M, Bruchfeld, J, Koleva, A, Piubello, A, Koirala, GS, Udwadia, ZF, Palmero, DJ, Munoz-Torrico, M, Gc, R, Gualano, G, Grecu, V, Motta, I, Papavasileiou, A, Li, Y, Hoefsloot, W, Kunst, H, Mazza-Stalder, J, Payen, M-C, Akkerman, OW, Bernal, E, Manfrin, V, Matteelli, A, Hamdan, HM, Marcos, MN, Cadinanos Loidi, J, Cebrian Gallardo, JJ, Duarte, R, Escobar Salinas, N, Gomez Rosso, R, Laniado-Laborin, R, Martinez Robles, E, Quiros Fernandez, S, Rendon, A, Solovic, I, Tadolini, M, Viggiani, P, Belilovski, E, Boeree, MJ, Cai, Q, Davidaviciene, E, Forsman, LD, De Los Rios, J, Draksiene, J, Duga, A, Elamin, SE, Filippov, A, Garcia, A, Gaudiesiute, I, Gavazova, B, Gayoso, R, Gruslys, V, Jonsson, J, Khimova, E, Madonsela, G, Magis-Escurra, C, Marchese, V, Matei, M, Moschos, C, Nakceriene, B, Nicod, L, Palmieri, F, Pontarelli, A, Smite, A, Souleymane, MB, Vescovo, M, Zablockis, R, Zhurkin, D, Alffenaar, J-W, Caminero, JA, Codecasa, LR, Garcia-Garcia, J-M, Esposito, S, Saderi, L, Spanevello, A, Visca, D, Tiberi, S, Pontali, E, Centis, R, D'Ambrosio, L, van den Boom, M, Sotgiuw, G, and Migliori, GB
- Abstract
The World Health Organization (WHO) recommends countries introduce new anti-TB drugs in the treatment of multidrug-resistant tuberculosis. The aim of the study is to prospectively evaluate the effectiveness of bedaquiline (and/or delamanid)- containing regimens in a large cohort of consecutive TB patients treated globally. This observational, prospective study is based on data collected and provided by Global Tuberculosis Network (GTN) centres and analysed twice a year. All consecutive patients (including children/adolescents) treated with bedaquiline and/or delamanid were enrolled, and managed according to WHO and national guidelines. Overall, 52 centres from 29 countries/regions in all continents reported 883 patients as of January 31st 2021, 24/29 countries/regions providing data on 100% of their consecutive patients (10-80% in the remaining 5 countries). The drug-resistance pattern of the patients was severe (>30% with extensively drug-resistant -TB; median number of resistant drugs 5 (3-7) in the overall cohort and 6 (4-8) among patients with a final outcome). For the patients with a final outcome (477/883, 54.0%) the median (IQR) number of months of anti-TB treatment was 18 (13-23) (in days 553 (385-678)). The proportion of patients achieving sputum smear and culture conversion ranged from 93.4% and 92.8% respectively (whole cohort) to 89.3% and 88.8% respectively (patients with a final outcome), a median (IQR) time to sputum smear and culture conversion of 58 (30-90) days for the whole cohort and 60 (30-100) for patients with a final outcome and, respectively, of 55 (30-90) and 60 (30-90) days for culture conversion. Of 383 patients treated with bedaquiline but not delamanid, 284 (74.2%) achieved treatment success, while 25 (6.5%) died, 11 (2.9%) failed and 63 (16.5%) were lost to follow-up.
- Published
- 2021
11. Brain contusions induce a strong local overexpression of MMP-9. Results of a pilot study
- Author
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Vilalta, A., primary, Sahuquillo, J., additional, Poca, M. A., additional, De Los Rios, J., additional, Cuadrado, E., additional, Ortega-Aznar, A., additional, Riveiro, M., additional, and Montaner, J., additional
- Published
- 2008
- Full Text
- View/download PDF
12. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
- Author
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Perkovic, V., Jardine, M. J., Neal, B., Bompoint, S., Heerspink, H. J. L., Charytan, D. M., Edwards, R., Agarwal, R., Bakris, G., Bull, S., Cannon, C. P., Capuano, G., Chu, P. -L., De Zeeuw, D., Greene, T., Levin, A., Pollock, C., Wheeler, D. C., Yavin, Y., Zhang, H., Zinman, B., Meininger, G., Brenner, B. M., Mahaffey, K. W., Perkovic, V, Mahaffey, Kw, Agarwal, R, Bakris, G, Brenner, Bm, Cannon, Cp, Charytan, Dm, de Zeeuw, D, Greene, T, Jardine, Mj, Heerspink, Hjl, Levin, A, Meininger, G, Neal, B, Pollock, C, Wheeler, Dc, Zhang, H, Zinman, B, Mcguire, Dk, Holman, R, Home, P, Scharfstein, D, Parfrey, P, Shahinfar, S, August, P, Chang, T, Sinha, Ad, Januzzi, J, Kolansky, D, Amerena, J, Hillis, G, Gorelick, P, Kissela, B, Kasner, S, Lindley, R, Fulcher, G, Ounadjela, S, Hufert, K, von Ingersleben, G, Gaglia, J, Harris, R, Hudson, M, Turchin, A, Cheifetz, A, Sheth, S, Feuerstein, J, Cohen, S, Jardine, M, Li, N, Kolesnyk, I, Aizenberg, D, Pecoits-Filho, R, Cherney, D 3rd, Obrador, G, Chertow, G, Hawley, C, Ji, L, Wada, T, Jha, V, Lim, Sk, Lim-Abrahan, Ma, Santos, F, Chae, Dw, Hwang, Sj, Vazelov, E, Rychlík, I, Hadjadj, S, Krane, V, Rosivall, L, De Nicola, L, Dreval, A, Nowicki, M, Schiller, A, Distiller, L, Górriz, Jl, Kolesnyk, M, Morren, F, Goykhman, S, David, C, Yost, L, Wang, H, Hettiarachchi, M, 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M, Harcsa, E, Keltai, K, Keresztesi, S, Kiss, K, Konyves, L, Major, L, Mileder, M, Molnar, M, Mucsi, J, Oroszlan, T, Ory, I, Paragh, G, Peterfai, E, Petro, G, Revesz, K, Takacs, R, Vangel, S, Vasas, S, Zsom, M, Abraham, O, Bhushan, R, Deepak, D, Edwin, Fm, Gopalakrishnan, N, Gracious, N, Hansraj, A, Jain, D, Keshavamurthy, Cb, Khullar, D, Manisha, S, Peringat, J, Prasad, N, Satyanarayana, Rk, Sreedhar, R, Sreelatha, M, Sudhakar, B, Vyasam, Rc, Bonadonna, R, Castellino, P, Ceriello, A, Chiovato, L, De Cosmo, S, Derosa, G, Di Carlo, A, Di Cianni, G, Frascà, G, Fuiano, G, Gambaro, G, Garibotto, G, Giorda, C, Malberti, F, Mandreoli, M, Mannucci, E, Orsi, E, Piatti, P, Santoro, D, Sasso, Fc, Serviddio, G, Stella, A, Trevisan, R, Veronelli, Am, Zanoli, L, Akiyama, H, Aoki, H, Asano, A, Iitsuka, T et al, Groningen Kidney Center (GKC), and Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)
- Subjects
Aged ,Canagliflozin ,Cardiovascular Diseases ,Creatinine ,Diabetes Mellitus, Type 2 ,Diabetic Nephropathies ,Double-Blind Method ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Humans ,Kidney Failure, Chronic ,Male ,Middle Aged ,Sodium-Glucose Transporter 2 Inhibitors ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Diabetic nephropathy ,Kidney Failure ,chemistry.chemical_compound ,0302 clinical medicine ,030212 general & internal medicine ,03.02. Klinikai orvostan ,Dapagliflozin ,Chronic ,11 Medical and Health Sciences ,EMPAGLIFLOZIN ,General Medicine ,Life Sciences & Biomedicine ,Type 2 ,medicine.drug ,medicine.medical_specialty ,Nephropathy ,03 medical and health sciences ,Medicine, General & Internal ,Internal medicine ,Diabetes mellitus ,General & Internal Medicine ,CREDENCE Trial Investigators ,medicine ,Diabetes Mellitus ,Science & Technology ,business.industry ,urogenital system ,diabetic nephropathy ,Type 2 Diabetes Mellitus ,KIDNEY-DISEASE ,medicine.disease ,chemistry ,business ,Kidney disease - Abstract
BACKGROUND: Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS: In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin-angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of
- Published
- 2019
13. Canagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups Results From the Randomized CREDENCE Trial
- Author
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- Abstract
BACKGROUND: Canagliflozin reduces the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, but effects on specific cardiovascular outcomes are uncertain, as are effects in people without previous cardiovascular disease (primary prevention). METHODS: In CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation), 4401 participants with type 2 diabetes mellitus and chronic kidney disease were randomly assigned to canagliflozin or placebo on a background of optimized standard of care. RESULTS: Primary prevention participants (n=2181, 49.6%) were younger (61 versus 65 years), were more often female (37% versus 31%), and had shorter duration of diabetes mellitus (15 years versus 16 years) compared with secondary prevention participants (n=2220, 50.4%). Canagliflozin reduced the risk of major cardiovascular events overall (hazard ratio [HR], 0.80 [95% CI, 0.67-0.95]; P=0.01), with consistent reductions in both the primary (HR, 0.68 [95% CI, 0.49-0.94]) and secondary (HR, 0.85 [95% CI, 0.69-1.06]) prevention groups (P for interaction=0.25). Effects were also similar for the components of the composite including cardiovascular death (HR, 0.78 [95% CI, 0.61-1.00]), nonfatal myocardial infarction (HR, 0.81 [95% CI, 0.59-1.10]), and nonfatal stroke (HR, 0.80 [95% CI, 0.56-1.15]). The risk of the primary composite renal outcome and the composite of cardiovascular death or hospitalization for heart failure were also consistently reduced in both the primary and secondary prevention groups (P for interaction >0.5 for each outcome). CONCLUSIONS: Canagliflozin significantly reduced major cardiovascular events and kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, including in participants who did not have previous cardiovascular disease. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02065791.
- Published
- 2019
14. Comparison of phenotypic and genotypic markers for characterization of an outbreak of Salmonella serotype Havana in captive raptors
- Author
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Reche, M. P., Echeita, M. A., de los Rios, J. E. García, Usera, M. A., Jiménez, P. A., Rojas, A. M., Colás, J., and Rodriguez, I.
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- 2003
15. The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics
- Author
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Abdallah J, Abdul Ghani R, Abdul Kadir K, Abdullah R, Abejuela Z, Abraham O, Abramowitz M, Abusnana S, Accini Mendoza JL, Acosta I, Agafyina A, Aggarwal N, Ahmed F, Ahuad Guerrero RA, Aiello J, Ainsworth P, Aizenberg D, Akiyama H, Akright L, Akyea-Djamson A, Alamartine E, Alappan R, Ali N, Ali Z, Alicic R, Al-Karadsheh A, Alpizar Salazar M, Alvarez Garcia P, Alvarisqueta A, Amodeo C, Andreeva V, Andreotti Turatti LA, Angelescu LM, Angelova A, Anghel V, Antic S, Aoki H, Aquitania G, Arauz-Pacheco C, Arce-Nunez E, Arcos Palma EG, Arfeen S, Arif A, Aronson R, Arutchelvam V, Asano A, Atray N, Avram RI, Awad A, Baas Cruz J, Babikova J, Badat A, Bajaj H, Baker J, Bakris G, Barbarash O, Barna O, Barnard M, Barranco E, Barrera C, Bartaskova D, Bartolacci I, Barysheva O, Behara V, Bellary S, Belo D, Bentley-Lewis R, Benusova O, Berenguer R, Berli MA, Bernardo M, Biscoveanu M, Bordonava AP, Borot S, Botsyurko V, Bowman-Stroud C, Brandon D, Bregman R, Brusco O, Buganova I, Burgos Soto M, Busch R, Busegeanu MM, Calella P, Camelo Sanches FC, Canaan Y, Canani LH, Cantero MC, Cariou B, Cartasegna LR, Castellino P, Cereto Castro F, Certow G, Chacra AR, Chae DW, Chang CT, Chang T, Che Yusof MD, Chen N, Chen Q, Cherney D, Cheung NW, Chevaile Ramos J, Chew Wong A, Chiovato L, Chizhov D, Cho YM, Christiano C, Christofides E, Chuang LM, Chuateco C, Cif A, Cigarran Guldris S, Cohen K, Cohen R, Coloma GC, Comia RS, Commendatore V, Conway J, Cook C, Cosma D, Cournoyer S, Coyne D, Crisan C, Csecsei G, Csiky B, Cuadrado J, Cuneo CA, Cunha Borges JL, Cunha Vêncio SA, Cusumano AM, da Silva Franco RJ, Daboul N, Danos P, DaRoza G, Davies E, Davies M, Davies S, Dawson A, De Cosmo S, De Nicola L, De Serres S, de Souza Portes E, Deak L, Deck K, Deepak D, Derosa G, Desouza C, Dev D, Dhillon M, DI CARLO, Alfonso, Di Cianni G, Diaz Escalante T, Dimitrov S, Distiller L, Djordjevic M, Dobronravov V, Dohnalova L, Dominguez Lopez M, Douthat WG, Dran RD, Drasnar T, Dreval A, Droste C, Dua S, Dube F, Dudar I, Dudas M, Dussol B, Dzupina A, Eder F, Egido de Los Rios J, El Kossi M, El-Shahawy M, English P, Enriquez Sosa FE, Ervin J, Esquenazi A, Evans J, Faghih M, Farias E, Faulmann G, Fauvel JP, Ferariu IE, Fernandez MF, Fernandez Fresnedo G, Fernandez Montenegro MA, Finkelstein H, Flores Lozano F, Flota Cervera L, Fraige Filho F, Fraser D, Frenk Baron P, Fretes JO, Frias J, Fuiano G, Fulop P, Fushtey I, Galan Serrano A, Galphin C, Gan S, Gan CL, Garcia NH, Garcia I, Garcia Ballesteros C, Garcia Ortiz LH, Garrido N, Gastaldi A, Gelersztein E, Geloneze Neto B, Genadieva V, Genova-Hristova G, Genovese S, Ghazi A, Giorda C, Glenny JA, Glinkina I, Godlevska O, Godoy Jorquera JG, Goldenberg R, Golovchenko O, Gomes Bastos M, Gomez O, Gomez Rangel JD, Gonzalez E, Gonzalez Dorado A, Gonzalez Martinez FJ, Gonzalez Orellana RA, Gopalakrishnan N, Gorriz JL, Gorson D, Govender V, Gracious N, Greco B, Gregar R, Greloni GC, Grineva E, Guinsburg A, Gulati R, Gunstone A, Gupta A, Gupta M, Gyrina O, Hadjadj S, Halciakova K, Hall T, Haller H, Halmagyi I, Hammoud J, Hancu N, Hanif W, Hansraj A, Hawley C, Henein S, Hermida S, Hernandez Triana E, Herrera Jimenez LE, Hershon K, Higuera Cobos JD, Hiser D, Hocking S, Hon G, Hristozov K, Hsieh CH, Hura C, Hwang SJ, Ilavska A, Irizar Santana SS, Ismail M, Jackson A, Jain D, Jamal A, Januszewicz A, Jeong IK, Jha V, Jimenez Flores F, Jodar Gimeno JE, Johnson A, Joseph F, Joshi M, Juncos LI, Jurgens J, Kajiyama S, Kaminska A, Kashine S, Kaupke C, Kawada T, Keiko Kohara S, Keitel E, Keltai K, Kendereski A, Keresztesi S, Kern E, Kerr Saraiva JF, Keshavamurthy CB, Khandwala H, Khanna R, Khitan Z, Khullar D, Kim SG, Kim YH, Kim S, Kiss K, Klein A, Klyver MI, Kodera T, Kolesnyk M, Kolmakova E, Komisarenko I, Kong Y, Kong WY, Kono H, Konyves L, Kopyt N, Korzh O, Kovar R, Kovesdy C, Koyama K, Kozloviene D, Kraft F, Krane V, Kravchun N, Krishna G, Krishnan S, Kropp JJ, Kumar A, Kumar J, Kumeda Y, Kumwenda M, Kurtz Lisboa HR, Kvitkova L, Kwon HS, Kwon MJ, Lalic K, Lalic N, Lanchiotti PV, Lastuvka J, Laviada Molina H, Lawrence M, Le Meur Y, Lee LY, Lee BW, Lee J, Lee MK, Legun O, Leiter L, Lentz J, Leon de la Fuente RA, Levin A, Lewis D, Li D, Li W, Li X, Lim SK, Lin H, Lin CC, Liss K, Liu J, Loh CL, Lombard L, Lopez Mendoza M, Lopez Tarabay C, Lorenzoni d'avila DO, Loss de Carvalho Contieri F, Lu W, Lu YC, Luna Ceballos R, M. Edwin F, MacDougall I, Macedo de Souza PA, Madej A, Madore F, Magalhaes Montenegro Junior R, Mah PM, Maheshwari H, Major L, Malberti F, Malek Marin T, Mandayam S, Mandreoli M, Manisha S, Mankovskyy B, Mannucci E, Manocha AB, Mao H, Marar I, Marasaev V, Marchetta N, Martin Del Campo Blanco B, Martinka E, Martynyuk L, Maxeiner S, Mazur S, McMahon A, Medina Farina M, Mehta B, Middleton J, Mileder M, Miyauchi S, Mizuyama K, Mkrtumyan A, Mlodawska-Choluj D, Molina de Salazar DI, Molnar M, Mookadam M, Morales Franco G, Morales Portillo C, Mordujovich J, Moreira de Brito C, Moreira Diaz JP, Moreno Loza OT, Mostovoy Y, Moustafa M, Muirhead N, Mujica Trenche S, Munar Vila MA, Munoz Torres M, Munteanu M, Mustieles Rocha C, Nagibovich G, Nam MS, Narvarte J, Nasser Hissa M, Navickas A, Nazario Sabbag ÂR, Nedogoda S, Negru D, Newman G, Ng KS, Ngcakani N, Nicholls K, Nicol P, Nieto Iglesias J, Niiya T, Nik Ahmad NNF, Nisnisan J, Nonchev B, Noronha IL, Nortje H, Nossuli AK, Nowicki M, Obialo C, Obrador Vera G, Ochodnicka Z, Oh KH, Oishi H, Olelewe S, Oliver M, Oosthuizen H, Orio SI, Orlowska-Kowalik G, Oroszlan T, Orozco Castellanos R, Orsi E, Ory I, O'Shaughnessy A, Ota S, Otreras F, Oviedo A, Packham D, Padron J, Panarotto D, Pankhaniya R, Pantoja Perez J, Paragh G, Park CY, Park SH, Pashkovska N, Patel D, Patel G, Pavon H, Pei D, Pella D, Penfornis A, Peralta Calcaneo J, Pereira MA, Pererva L, Perez Vera M, Peringat J, Pertseva T, Pesickova S, Peterfai E, Peterka K, Petrica L, Petro G, Pettis K, Pharr W, Philip S, Phillips A, Piatti P, Pichette V, Pontiroli A, Popa AR, Popenda G, Popovic-Radinovic V, Portoles Perez JM, Prasad N, Proietto J, Prozesky H, Pumprla J, Purighalla R, Quesada Simon MA, Quesada-Suarez L, Rabasa-Lhoret R, Ramirez Roca LA, Ramtoola S, Ranetti AE, Rangelov R, Ranjan R, Raskina T, Rastogi S, Ratnasingam V, Reddy J, Ren Y, Resk JH, Rewerska B, Reyes Rosano MA, Rich L, Rista L, Roberts A, Robinson M, Rodelo J, Rodriguez H, Rodriguez Papini N, Roger S, Rosas S, Rosas Guzman J, Rosivall L, Roussel R, Rucker Joerg IE, Rychlik I, Saavedra Gajardo V, Saavedra Sanchez SB, Sala J, Samoylov O, Samoylova Y, Sanchez Arenales JA, Sanchez Mijangos JH, Sanchez Polo JV, Sankaram R, Santoro D, Santos JC, Santos F, Sarin R, Saudek F, Saumell F, Saxena M, Sazonova O, Schiavi LB, Schiller A, Schuch T, Scott R, Scott D, Seeber M, Seiji Yamada S, Sekkarie M, Sensenbrenner J, Serafinceanu C, Serrano Sanson P, Sessa H, Shakeel M, Shamkhalova M, Shanik M, Shaw S, Sheu WH, Shinkov A, Shutemova E, Silva Pecoits Filho RF, Simo Canonge R, Simoes de Almeida R, Simon G, Singh B, Slompo Ramos C, Smatanova I, Smirnov I, Smith S, Smith Casabella T, Soares Felicio J, Soler Romeo MJ, Solomon R, Song W, Soto Gonzalez A, Sowinski D, Sprague A, Sree Bhushan R, Sreedhar R, Sreelatha M, Steele A, SPEDDING, Stephen John, Strzelecka A, Suchinda P, Sudhakar B, Sun J, Sun L, Surampudi P, Sussman S, Svyshchenko Y, Symonds R, Szlachcic Y, Takacs R, Takai M, Tamayo Y. Orozco J, Tan G, Tellez Chavez E, Temelkova M, Terns Riera M, Terront Lozano MA, Tesar V, Thompson M, Tibes Hachmann JC, Tinahones Madueno FJ, Tolentino M, Tomashkevych H, Tomonaga O, Topchii I, Torshizi A, Trespalacios F, Trevisan R, Trueba P, Tryshchuk N, Tseluyko V, Tsujimoto M, Tu P, Turcios Juarez E, Turner W, Twahirwa M, Ulla MR, Updegrove J, Urbanaviciene E, Valderrama Cometa L, Valdes Cepeda A, Valenzuela A, Valis M, Vallejos A, Vangel S, Vannorsdall M, Vargas Alonso RD, Varghese F, Vasas S, Vazelov E, Vejar M, Velasquez-Mieyer P, Velichkova E, Velo M, Venegas Carrillo L, Vengadasalam P, Ventrapragada S, Villagordoa Mesa J, Villarino AA, Villegas I, Visco VE, Vizir V, Vlasenko M, Vyasam RC, Wada T, Wadud K, Wahba M, Wakasugi M, Wakeling J, Wakida Y, WALKER, JOHN RICHARD, Wang G, Warren M, Wassermann A, Watanabe T, Watson E, Watts R, Weiner P, Weiner D, Welsh J, Wheeler D, Williams M, Winocour P, Woo V, Yamada M, Yanagida K, Yanase T, Yang J, Yao C, Yap YE, Ygpuara MDL, Yin A, Yoiti Hayashida C, Yoon KH, Young S, Yu X, Yumita W, Yupanqui H, Zaidman CJ, Zamarripa Escobedo R, Zanata Petry TB, Zanella MT, Zaoui P, Zavaroni I, Zemek S, Zhang H, Zhao M, Zheng H, Zlova T, Zsom M, Zykova T., Groningen Kidney Center (GKC), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Abdallah, J, Abdul Ghani, R, Abdul Kadir, K, Abdullah, R, Abejuela, Z, Abraham, O, Abramowitz, M, Abusnana, S, Accini Mendoza, Jl, Acosta, I, Agafyina, A, Aggarwal, N, Ahmed, F, Ahuad Guerrero, Ra, Aiello, J, Ainsworth, P, Aizenberg, D, Akiyama, H, Akright, L, Akyea-Djamson, A, Alamartine, E, Alappan, R, Ali, N, Ali, Z, Alicic, R, Al-Karadsheh, A, Alpizar Salazar, M, Alvarez Garcia, P, Alvarisqueta, A, Amodeo, C, Andreeva, V, Andreotti Turatti, La, Angelescu, Lm, Angelova, A, Anghel, V, Antic, S, Aoki, H, Aquitania, G, Arauz-Pacheco, C, Arce-Nunez, E, Arcos Palma, Eg, Arfeen, S, Arif, A, Aronson, R, Arutchelvam, V, Asano, A, Atray, N, Avram, Ri, Awad, A, Baas Cruz, J, Babikova, J, Badat, A, Bajaj, H, Baker, J, Bakris, G, Barbarash, O, Barna, O, Barnard, M, Barranco, E, Barrera, C, Bartaskova, D, Bartolacci, I, Barysheva, O, Behara, V, Bellary, S, Belo, D, Bentley-Lewis, R, Benusova, O, Berenguer, R, Berli, Ma, Bernardo, M, Biscoveanu, M, Bordonava, Ap, Borot, S, Botsyurko, V, Bowman-Stroud, C, Brandon, D, Bregman, R, Brusco, O, Buganova, I, Burgos Soto, M, Busch, R, Busegeanu, Mm, Calella, P, Camelo Sanches, Fc, Canaan, Y, Canani, Lh, Cantero, Mc, Cariou, B, Cartasegna, Lr, Castellino, P, Cereto Castro, F, Certow, G, Chacra, Ar, Chae, Dw, Chang, Ct, Chang, T, Che Yusof, Md, Chen, N, Chen, Q, Cherney, D, Cheung, Nw, Chevaile Ramos, J, Chew Wong, A, Chiovato, L, Chizhov, D, Cho, Ym, Christiano, C, Christofides, E, Chuang, Lm, Chuateco, C, Cif, A, Cigarran Guldris, S, Cohen, K, Cohen, R, Coloma, Gc, Comia, R, Commendatore, V, Conway, J, Cook, C, Cosma, D, Cournoyer, S, Coyne, D, Crisan, C, Csecsei, G, Csiky, B, Cuadrado, J, Cuneo, Ca, Cunha Borges, Jl, Cunha Vêncio, Sa, Cusumano, Am, da Silva Franco, Rj, Daboul, N, Danos, P, Daroza, G, Davies, E, Davies, M, Davies, S, Dawson, A, De Cosmo, S, De Nicola, L, De Serres, S, de Souza Portes, E, Deak, L, Deck, K, Deepak, D, Derosa, G, Desouza, C, Dev, D, Dhillon, M, DI CARLO, Alfonso, Di Cianni, G, Diaz Escalante, T, Dimitrov, S, Distiller, L, Djordjevic, M, Dobronravov, V, Dohnalova, L, Dominguez Lopez, M, Douthat, Wg, Dran, Rd, Drasnar, T, Dreval, A, Droste, C, Dua, S, Dube, F, Dudar, I, Dudas, M, Dussol, B, Dzupina, A, Eder, F, Egido de Los Rios, J, El Kossi, M, El-Shahawy, M, English, P, Enriquez Sosa, Fe, Ervin, J, Esquenazi, A, Evans, J, Faghih, M, Farias, E, Faulmann, G, Fauvel, Jp, Ferariu, Ie, Fernandez, Mf, Fernandez Fresnedo, G, Fernandez Montenegro, Ma, Finkelstein, H, Flores Lozano, F, Flota Cervera, L, Fraige Filho, F, Fraser, D, Frenk Baron, P, Fretes, Jo, Frias, J, Fuiano, G, Fulop, P, Fushtey, I, Galan Serrano, A, Galphin, C, Gan, S, Gan, Cl, Garcia, Nh, Garcia, I, Garcia Ballesteros, C, Garcia Ortiz, Lh, Garrido, N, Gastaldi, A, Gelersztein, E, Geloneze Neto, B, Genadieva, V, Genova-Hristova, G, Genovese, S, Ghazi, A, Giorda, C, Glenny, Ja, Glinkina, I, Godlevska, O, Godoy Jorquera, Jg, Goldenberg, R, Golovchenko, O, Gomes Bastos, M, Gomez, O, Gomez Rangel, Jd, Gonzalez, E, Gonzalez Dorado, A, Gonzalez Martinez, Fj, Gonzalez Orellana, Ra, Gopalakrishnan, N, Gorriz, Jl, Gorson, D, Govender, V, Gracious, N, Greco, B, Gregar, R, Greloni, Gc, Grineva, E, Guinsburg, A, Gulati, R, Gunstone, A, Gupta, A, Gupta, M, Gyrina, O, Hadjadj, S, Halciakova, K, Hall, T, Haller, H, Halmagyi, I, Hammoud, J, Hancu, N, Hanif, W, Hansraj, A, Hawley, C, Henein, S, Hermida, S, Hernandez Triana, E, Herrera Jimenez, Le, Hershon, K, Higuera Cobos, Jd, Hiser, D, Hocking, S, Hon, G, Hristozov, K, Hsieh, Ch, Hura, C, Hwang, Sj, Ilavska, A, Irizar Santana, S, Ismail, M, Jackson, A, Jain, D, Jamal, A, Januszewicz, A, Jeong, Ik, Jha, V, Jimenez Flores, F, Jodar Gimeno, Je, Johnson, A, Joseph, F, Joshi, M, Juncos, Li, Jurgens, J, Kajiyama, S, Kaminska, A, Kashine, S, Kaupke, C, Kawada, T, Keiko Kohara, S, Keitel, E, Keltai, K, Kendereski, A, Keresztesi, S, Kern, E, Kerr Saraiva, Jf, Keshavamurthy, Cb, Khandwala, H, Khanna, R, Khitan, Z, Khullar, D, Kim, Sg, Kim, Yh, Kim, S, Kiss, K, Klein, A, Klyver, Mi, Kodera, T, Kolesnyk, M, Kolmakova, E, Komisarenko, I, Kong, Y, Kong, Wy, Kono, H, Konyves, L, Kopyt, N, Korzh, O, Kovar, R, Kovesdy, C, Koyama, K, Kozloviene, D, Kraft, F, Krane, V, Kravchun, N, Krishna, G, Krishnan, S, Kropp, Jj, Kumar, A, Kumar, J, Kumeda, Y, Kumwenda, M, Kurtz Lisboa, Hr, Kvitkova, L, Kwon, H, Kwon, Mj, Lalic, K, Lalic, N, Lanchiotti, Pv, Lastuvka, J, Laviada Molina, H, Lawrence, M, Le Meur, Y, Lee, Ly, Lee, Bw, Lee, J, Lee, Mk, Legun, O, Leiter, L, Lentz, J, Leon de la Fuente, Ra, Levin, A, Lewis, D, Li, D, Li, W, Li, X, Lim, Sk, Lin, H, Lin, Cc, Liss, K, Liu, J, Loh, Cl, Lombard, L, Lopez Mendoza, M, Lopez Tarabay, C, Lorenzoni d'avila, Do, Loss de Carvalho Contieri, F, Lu, W, Lu, Yc, Luna Ceballos, R, M., Edwin F, Macdougall, I, Macedo de Souza, Pa, Madej, A, Madore, F, Magalhaes Montenegro Junior, R, Mah, Pm, Maheshwari, H, Major, L, Malberti, F, Malek Marin, T, Mandayam, S, Mandreoli, M, Manisha, S, Mankovskyy, B, Mannucci, E, Manocha, Ab, Mao, H, Marar, I, Marasaev, V, Marchetta, N, Martin Del Campo Blanco, B, Martinka, E, Martynyuk, L, Maxeiner, S, Mazur, S, Mcmahon, A, Medina Farina, M, Mehta, B, Middleton, J, Mileder, M, Miyauchi, S, Mizuyama, K, Mkrtumyan, A, Mlodawska-Choluj, D, Molina de Salazar, Di, Molnar, M, Mookadam, M, Morales Franco, G, Morales Portillo, C, Mordujovich, J, Moreira de Brito, C, Moreira Diaz, Jp, Moreno Loza, Ot, Mostovoy, Y, Moustafa, M, Muirhead, N, Mujica Trenche, S, Munar Vila, Ma, Munoz Torres, M, Munteanu, M, Mustieles Rocha, C, Nagibovich, G, Nam, M, Narvarte, J, Nasser Hissa, M, Navickas, A, Nazario Sabbag, Âr, Nedogoda, S, Negru, D, Newman, G, Ng, K, Ngcakani, N, Nicholls, K, Nicol, P, Nieto Iglesias, J, Niiya, T, Nik Ahmad, Nnf, Nisnisan, J, Nonchev, B, Noronha, Il, Nortje, H, Nossuli, Ak, Nowicki, M, Obialo, C, Obrador Vera, G, Ochodnicka, Z, Oh, Kh, Oishi, H, Olelewe, S, Oliver, M, Oosthuizen, H, Orio, Si, Orlowska-Kowalik, G, Oroszlan, T, Orozco Castellanos, R, Orsi, E, Ory, I, O'Shaughnessy, A, Ota, S, Otreras, F, Oviedo, A, Packham, D, Padron, J, Panarotto, D, Pankhaniya, R, Pantoja Perez, J, Paragh, G, Park, Cy, Park, Sh, Pashkovska, N, Patel, D, Patel, G, Pavon, H, Pei, D, Pella, D, Penfornis, A, Peralta Calcaneo, J, Pereira, Ma, Pererva, L, Perez Vera, M, Peringat, J, Pertseva, T, Pesickova, S, Peterfai, E, Peterka, K, Petrica, L, Petro, G, Pettis, K, Pharr, W, Philip, S, Phillips, A, Piatti, P, Pichette, V, Pontiroli, A, Popa, Ar, Popenda, G, Popovic-Radinovic, V, Portoles Perez, Jm, Prasad, N, Proietto, J, Prozesky, H, Pumprla, J, Purighalla, R, Quesada Simon, Ma, Quesada-Suarez, L, Rabasa-Lhoret, R, Ramirez Roca, La, Ramtoola, S, Ranetti, Ae, Rangelov, R, Ranjan, R, Raskina, T, Rastogi, S, Ratnasingam, V, Reddy, J, Ren, Y, Resk, Jh, Rewerska, B, Reyes Rosano, Ma, Rich, L, Rista, L, Roberts, A, Robinson, M, Rodelo, J, Rodriguez, H, Rodriguez Papini, N, Roger, S, Rosas, S, Rosas Guzman, J, Rosivall, L, Roussel, R, Rucker Joerg, Ie, Rychlik, I, Saavedra Gajardo, V, Saavedra Sanchez, Sb, Sala, J, Samoylov, O, Samoylova, Y, Sanchez Arenales, Ja, Sanchez Mijangos, Jh, Sanchez Polo, Jv, Sankaram, R, Santoro, D, Santos, Jc, Santos, F, Sarin, R, Saudek, F, Saumell, F, Saxena, M, Sazonova, O, Schiavi, Lb, Schiller, A, Schuch, T, Scott, R, Scott, D, Seeber, M, Seiji Yamada, S, Sekkarie, M, Sensenbrenner, J, Serafinceanu, C, Serrano Sanson, P, Sessa, H, Shakeel, M, Shamkhalova, M, Shanik, M, Shaw, S, Sheu, Wh, Shinkov, A, Shutemova, E, Silva Pecoits Filho, Rf, Simo Canonge, R, Simoes de Almeida, R, Simon, G, Singh, B, Slompo Ramos, C, Smatanova, I, Smirnov, I, Smith, S, Smith Casabella, T, Soares Felicio, J, Soler Romeo, Mj, Solomon, R, Song, W, Soto Gonzalez, A, Sowinski, D, Sprague, A, Sree Bhushan, R, Sreedhar, R, Sreelatha, M, Steele, A, Spedding, Stephen John, Strzelecka, A, Suchinda, P, Sudhakar, B, Sun, J, Sun, L, Surampudi, P, Sussman, S, Svyshchenko, Y, Symonds, R, Szlachcic, Y, Takacs, R, Takai, M, Tamayo Y., Orozco J, Tan, G, Tellez Chavez, E, Temelkova, M, Terns Riera, M, Terront Lozano, Ma, Tesar, V, Thompson, M, Tibes Hachmann, Jc, Tinahones Madueno, Fj, Tolentino, M, Tomashkevych, H, Tomonaga, O, Topchii, I, Torshizi, A, Trespalacios, F, Trevisan, R, Trueba, P, Tryshchuk, N, Tseluyko, V, Tsujimoto, M, Tu, P, Turcios Juarez, E, Turner, W, Twahirwa, M, Ulla, Mr, Updegrove, J, Urbanaviciene, E, Valderrama Cometa, L, Valdes Cepeda, A, Valenzuela, A, Valis, M, Vallejos, A, Vangel, S, Vannorsdall, M, Vargas Alonso, Rd, Varghese, F, Vasas, S, Vazelov, E, Vejar, M, Velasquez-Mieyer, P, Velichkova, E, Velo, M, Venegas Carrillo, L, Vengadasalam, P, Ventrapragada, S, Villagordoa Mesa, J, Villarino, Aa, Villegas, I, Visco, Ve, Vizir, V, Vlasenko, M, Vyasam, Rc, Wada, T, Wadud, K, Wahba, M, Wakasugi, M, Wakeling, J, Wakida, Y, Walker, JOHN RICHARD, Wang, G, Warren, M, Wassermann, A, Watanabe, T, Watson, E, Watts, R, Weiner, P, Weiner, D, Welsh, J, Wheeler, D, Williams, M, Winocour, P, Woo, V, Yamada, M, Yanagida, K, Yanase, T, Yang, J, Yao, C, Yap, Ye, Ygpuara, Mdl, Yin, A, Yoiti Hayashida, C, Yoon, Kh, Young, S, Yu, X, Yumita, W, Yupanqui, H, Zaidman, Cj, Zamarripa Escobedo, R, Zanata Petry, Tb, Zanella, Mt, Zaoui, P, Zavaroni, I, Zemek, S, Zhang, H, Zhao, M, Zheng, H, Zlova, T, Zsom, M, and Zykova, T.
- Subjects
medicine.medical_specialty ,ALBUMINURIA ,Urology ,Renal function ,030209 endocrinology & metabolism ,PROGRESSION ,Type 2 diabetes ,Diabetic nephropathy ,030204 cardiovascular system & hematology ,GLOMERULAR-FILTRATION-RATE ,CARDIOVASCULAR OUTCOMES ,Nephropathy ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Chronic kidney disease ,medicine ,03.02. Klinikai orvostan ,Renal outcome ,Canagliflozin ,Science & Technology ,ATRIAL-NATRIURETIC-PEPTIDE ,IRBESARTAN ,GFR DECLINE ,business.industry ,1103 Clinical Sciences ,KIDNEY-DISEASE ,Urology & Nephrology ,medicine.disease ,Renal outcomes ,Nephrology ,COLLABORATIVE METAANALYSIS ,Albuminuria ,Original Report: Patient-Oriented, Translational Research ,LOSARTAN ,medicine.symptom ,business ,Life Sciences & Biomedicine ,CREDENCE study investigators ,medicine.drug ,Kidney disease - Abstract
Background: People with diabetes and kidney disease have a high risk of cardiovascular events and progression of kidney disease. Sodium glucose co-transporter 2 inhibitors lower plasma glucose by reducing the uptake of filtered glucose in the kidney tubule, leading to increased urinary glucose excretion. They have been repeatedly shown to induce modest natriuresis and reduce HbA1c, blood pressure, weight, and albuminuria in patients with type 2 diabetes. However, the effects of these agents on kidney and cardiovascular events have not been extensively studied in patients with type 2 diabetes and established kidney disease. Methods: The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial aims to compare the efficacy and safety of canagliflozin versus placebo at preventing clinically important kidney and cardiovascular outcomes in patients with diabetes and established kidney disease. CREDENCE is a randomized, double-blind, event-driven, placebo-controlled trial set in in 34 countries with a projected duration of ∼5.5 years and enrolling 4,401 adults with type 2 diabetes, estimated glomerular filtration rate ≥30 to 2, and albuminuria (urinary albumin:creatinine ratio >300 to ≤5,000 mg/g). The study has 90% power to detect a 20% reduction in the risk of the primary outcome (α = 0.05), the composite of end-stage kidney disease, doubling of serum creatinine, and renal or cardiovascular death. Conclusion: CREDENCE will provide definitive evidence about the effects of canagliflozin on renal (and cardiovascular) outcomes in patients with type 2 diabetes and established kidney disease. Trial Registration: EudraCT number: 2013-004494-28; ClinicalTrials.gov identifier: NCT02065791.
- Published
- 2017
16. First observations of speed of light tracks by a fluorescence detector looking down on the atmosphere
- Author
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Abdellaoui, G., Abe, S., Adams, J. H., Jr., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Ave Pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Benmessai, K., Bertainaek, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Blecki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J-N, Capel, Francesca, Caramete, A., Caramete, L., Carlson, Per, Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V, Conti, L., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Cummings, A., Dagoret-Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Damian, A. Diaz, Djemil, T., Dutan, I, Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenuek, F., Fernandez-Gonzalez, S., Fernandez-Soriano, J., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, Christer, Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., Garcia-Ortega, E., Garipov, G., Gascon, E., Genci, J., Giraudo, G., Gonzalez Alvarado, C., Gorodetzky, P., Greg, R., Guarino, F., Guzman, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernandez Carretero, J., Hidber Cruz, W., Ikeda, D., Inoue, N., Inoue, S., Isgro, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I, Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I, Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lachaud, C., Lahmar, H., Lakhdari, F., Larson, R., Larsson, Oscar, Lee, J., Licandro, J., Lopez Campano, L., Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Marszal, W., Martens, K., Martin, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Mastafa, M., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Mendoza, M. A., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Morales de los Rios, J. A., Moretto, C., Nagataki, S., Naitamor, S., Napolitano, T., Naslund, W., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. , V, Orleanski, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. , I, Panico, B., Pasqualino, G., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Perez-Grande, I, Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonski, Z., Popescu, E. M., Prat, P., Prevot, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Rodriguez Frias, M. D., Rodencal, M., Ronga, F., Roudil, G., Rusinov, I, Rybczynski, M., Sabau, M. D., Saez Cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sanchez Balanzar, J. C., Sanchez, J. L., Santangelo, A., Sanz-Andres, A., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V, Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shinozaki, K., Shirahama, T., Spataro, B., Stan, I, Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traiche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villasenor, L., Vlcek, B., Von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts, J., Jr., Weber, M., Weigand Munoz, R., Weindl, A., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. , V, Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu, Marchi, A. Zuccaro, Abdellaoui, G., Abe, S., Adams, J. H., Jr., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Ave Pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Benmessai, K., Bertainaek, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Blecki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J-N, Capel, Francesca, Caramete, A., Caramete, L., Carlson, Per, Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V, Conti, L., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Cummings, A., Dagoret-Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Damian, A. Diaz, Djemil, T., Dutan, I, Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenuek, F., Fernandez-Gonzalez, S., Fernandez-Soriano, J., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, Christer, Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., Garcia-Ortega, E., Garipov, G., Gascon, E., Genci, J., Giraudo, G., Gonzalez Alvarado, C., Gorodetzky, P., Greg, R., Guarino, F., Guzman, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernandez Carretero, J., Hidber Cruz, W., Ikeda, D., Inoue, N., Inoue, S., Isgro, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I, Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I, Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lachaud, C., Lahmar, H., Lakhdari, F., Larson, R., Larsson, Oscar, Lee, J., Licandro, J., Lopez Campano, L., Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Marszal, W., Martens, K., Martin, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Mastafa, M., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Mendoza, M. A., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Morales de los Rios, J. A., Moretto, C., Nagataki, S., Naitamor, S., Napolitano, T., Naslund, W., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. , V, Orleanski, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. , I, Panico, B., Pasqualino, G., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Perez-Grande, I, Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonski, Z., Popescu, E. M., Prat, P., Prevot, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Rodriguez Frias, M. D., Rodencal, M., Ronga, F., Roudil, G., Rusinov, I, Rybczynski, M., Sabau, M. D., Saez Cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sanchez Balanzar, J. C., Sanchez, J. L., Santangelo, A., Sanz-Andres, A., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V, Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shinozaki, K., Shirahama, T., Spataro, B., Stan, I, Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traiche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villasenor, L., Vlcek, B., Von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts, J., Jr., Weber, M., Weigand Munoz, R., Weindl, A., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. , V, Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu, and Marchi, A. Zuccaro
- Abstract
EUSO-Balloon is a pathfinder mission for the Extreme Universe Space Observatory onboard the Japanese Experiment Module (JEM-EUSO). It was launched on the moonless night of the 25(th) of August 2014 from Timmins, Canada. The flight ended successfully after maintaining the target altitude of 38 km for five hours. One part of the mission was a 2.5 hour underflight using a helicopter equipped with three UV light sources (LED, xenon flasher and laser) to perform an inflight calibration and examine the detectors capability to measure tracks moving at the speed of light. We describe the helicopter laser system and details of the underflight as well as how the laser tracks were recorded and found in the data. These are the first recorded laser tracks measured from a fluorescence detector looking down on the atmosphere. Finally, we present a first reconstruction of the direction of the laser tracks relative to the detector., QC 20180903
- Published
- 2018
- Full Text
- View/download PDF
17. Meteor studies in the framework of the JEM-EUSO program
- Author
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Abdellaoui, G., Abe, S., Acheli, A., Adams, J. H. J. H., Ahmad, S., Ahriche, A., Albert, J. -N, Allard, D., Alonso, G., Anchordoqui, L., Andreev, V., Anzalone, A., Aouimeure, W., Arai, Y., Arsene, N., Asano, K., Attallah, R., Attoui, H., Pemas, M. Ave, Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Batsch, T., Bayer, J., Bechini, R., Belenguer, T., Bellotti, R., Belov, A., Belov, K., Benadda, B., Benmessai, K., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Blecki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bonamente, M., Boudaoud, R., Bozzo, E., Briggs, M. S., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J. -N, Capel, Francesca, Caramete, A., Caramete, L., Carlson, Per, Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Castellini, G., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Crawford, H. J., Cremonini, R., Csorna, S., Dagoret-Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Djemil, T., Djenas, S. A., Dulucq, F., Dupieux, M., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fang, K., Fenu, F., Fernandez-Gonzalez, S., Fernandez-Soriano, J., Ferrarese, S., Finco, D., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, Christer, Fujimoto, J., Fukushima, M., Galeotti, P., Garcia-Ortega, E., Garipov, G., Gascon, E., Geary, J., Gelmini, G., Genci, J., Giraudo, G., Gonchar, M., Alvarado, C. Gonzalez, Gorodetzky, P., Guarino, F., Guehaz, R., Guzman, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Carretero, J. Hernandez, Hidber, W., Higashide, K., Ikeda, D., Ikeda, H., Inoue, N., Inoue, S., Isgro, F., Itow, Y., Jammer, T., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kang, D., Kanouni, F., Karadzhov, Y., Karczmarczyk, J., Karus, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kim, Sug-Whan, Kleifges, M., Klimov, P. A., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lacombe, M., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, Oscar, Lee, J., Licandro, J., Lim, H., Campano, L. Lopez, Maccarone, M. C., Mackovjak, S., Mandi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Martens, K., Martin, Y., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Mehrad, L., Mendoza, M. A., Merino, A., Memik, T., Meseguer, J., Messaoud, S., Micu, O., Mimouni, J., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monaco, A., Monnier-Ragaigne, D., de los Rios, J. A. Morales, Moretto, C., Morozenko, V. S., Mot, B., Murakami, T., Nadji, B., Nagano, M., Nagata, M., Nagataki, S., Nakamura, T., Napolitano, T., Nardellis, A., Naumov, D., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleariski, P., Osteria, G., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Park, H. W., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Perdichizzi, M., Perez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pierog, T., Pindado, S., Piotrowski, L. W., Pirainou, S., Placidis, L., Plebaniak, Z., Pliego, S., Pollini, A., Popescu, E. M., Prat, P., Prevot, G., Prieto, H., Putis, M., Rabanal, J., Radu, A. A., Rahmani, M., Reardon, P., Reyes, M., Rezazadeh, M., Ricci, M., Frias, M. D. Rodriguez, Ronga, F., Roth, M., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Cano, G. Saez, Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sanchez, J. C., Sanchez, J. L., Santangelo, A., Cruz, L. Santiago, Sanz-Andres, A., Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, V., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec-Ozieblo, G., Sledd, J., Slomiriska, K., Sobey, A., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tahi, H., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traiche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tymieniecka, T., Uchihori, Y., Unger, M., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villasenor, L., Vicek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watanabe, S., Watts, J., Jr., Weber, M., Munoz, R. Weigand, Weindl, A., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., Marchi, A. Zuccaro, Abdellaoui, G., Abe, S., Acheli, A., Adams, J. H. J. H., Ahmad, S., Ahriche, A., Albert, J. -N, Allard, D., Alonso, G., Anchordoqui, L., Andreev, V., Anzalone, A., Aouimeure, W., Arai, Y., Arsene, N., Asano, K., Attallah, R., Attoui, H., Pemas, M. Ave, Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Batsch, T., Bayer, J., Bechini, R., Belenguer, T., Bellotti, R., Belov, A., Belov, K., Benadda, B., Benmessai, K., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Blecki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bonamente, M., Boudaoud, R., Bozzo, E., Briggs, M. S., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J. -N, Capel, Francesca, Caramete, A., Caramete, L., Carlson, Per, Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Castellini, G., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Crawford, H. J., Cremonini, R., Csorna, S., Dagoret-Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Djemil, T., Djenas, S. A., Dulucq, F., Dupieux, M., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fang, K., Fenu, F., Fernandez-Gonzalez, S., Fernandez-Soriano, J., Ferrarese, S., Finco, D., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, Christer, Fujimoto, J., Fukushima, M., Galeotti, P., Garcia-Ortega, E., Garipov, G., Gascon, E., Geary, J., Gelmini, G., Genci, J., Giraudo, G., Gonchar, M., Alvarado, C. Gonzalez, Gorodetzky, P., Guarino, F., Guehaz, R., Guzman, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Carretero, J. Hernandez, Hidber, W., Higashide, K., Ikeda, D., Ikeda, H., Inoue, N., Inoue, S., Isgro, F., Itow, Y., Jammer, T., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kang, D., Kanouni, F., Karadzhov, Y., Karczmarczyk, J., Karus, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kim, Sug-Whan, Kleifges, M., Klimov, P. A., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lacombe, M., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, Oscar, Lee, J., Licandro, J., Lim, H., Campano, L. Lopez, Maccarone, M. C., Mackovjak, S., Mandi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Martens, K., Martin, Y., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Mehrad, L., Mendoza, M. A., Merino, A., Memik, T., Meseguer, J., Messaoud, S., Micu, O., Mimouni, J., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monaco, A., Monnier-Ragaigne, D., de los Rios, J. A. Morales, Moretto, C., Morozenko, V. S., Mot, B., Murakami, T., Nadji, B., Nagano, M., Nagata, M., Nagataki, S., Nakamura, T., Napolitano, T., Nardellis, A., Naumov, D., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleariski, P., Osteria, G., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Park, H. W., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Perdichizzi, M., Perez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pierog, T., Pindado, S., Piotrowski, L. W., Pirainou, S., Placidis, L., Plebaniak, Z., Pliego, S., Pollini, A., Popescu, E. M., Prat, P., Prevot, G., Prieto, H., Putis, M., Rabanal, J., Radu, A. A., Rahmani, M., Reardon, P., Reyes, M., Rezazadeh, M., Ricci, M., Frias, M. D. Rodriguez, Ronga, F., Roth, M., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Cano, G. Saez, Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sanchez, J. C., Sanchez, J. L., Santangelo, A., Cruz, L. Santiago, Sanz-Andres, A., Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, V., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec-Ozieblo, G., Sledd, J., Slomiriska, K., Sobey, A., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tahi, H., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traiche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tymieniecka, T., Uchihori, Y., Unger, M., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villasenor, L., Vicek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watanabe, S., Watts, J., Jr., Weber, M., Munoz, R. Weigand, Weindl, A., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., and Marchi, A. Zuccaro
- Abstract
We summarize the state of the art of a program of UV observations from space of meteor phenomena, a secondary objective of the JEM-EUSO international collaboration. Our preliminary analysis indicates that JEM-EUSO, taking advantage of its large FOV and good sensitivity, should be able to detect meteors down to absolute magnitude close to 7. This means that JEM-EUSO should be able to record a statistically significant flux of meteors, including both sporadic ones, and events produced by different meteor streams. Being unaffected by adverse weather conditions, JEM-EUSO can also be a very important facility for the detection of bright meteors and fireballs, as these events can be detected even in conditions of very high sky background. In the case of bright events, moreover, exhibiting some persistence of the meteor train, preliminary simulations show that it should be possible to exploit the motion of the ISS itself and derive at least a rough 3D reconstruction of the meteor trajectory. Moreover, the observing strategy developed to detect meteors may also be applied to the detection of nuclearites, exotic particles whose existence has been suggested by some theoretical investigations. Nuclearites are expected to move at higher velocities than meteoroids, and to exhibit a wider range of possible trajectories, including particles moving upward after crossing the Earth. Some pilot studies, including the approved Mini-EUSO mission, a precursor of JEM-EUSO, are currently operational or in preparation. We are doing simulations to assess the performance of Mini-EUSO for meteor studies, while a few meteor events have been already detected using the ground-based facility EUSO-TA., QC 20170803
- Published
- 2017
- Full Text
- View/download PDF
18. A sensitivity assessment of multidimensional poverty to various sets of missing dimensions' indicators : the Chilean case
- Author
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De Los Rios, C and De Los Rios, J
- Abstract
This draft paper examines the sensitivity of multidimensional poverty in Chile to various sets of missing dimensions, including quality of employment, empowerment or agency, physical safety, and the ability to go about without shame.
- Published
- 2016
19. Corneal involvement due to Erdheim-Chester disease
- Author
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Díez de los Ríos, J., Serra Batlles, J., and Ruiz, F.
- Published
- 2019
- Full Text
- View/download PDF
20. Afectación corneal debido a enfermedad de Erdheim-Chester
- Author
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Díez de los Ríos, J., Serra Batlles, J., and Ruiz, F.
- Published
- 2019
- Full Text
- View/download PDF
21. TEM Study of Polycrystalline Co-Ni-Ga for Applications of Shape Memory Alloys
- Author
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Sanchez-Carrillo, M., primary, de los Rios, J. P. Flores, additional, Morales-Rodriguez, H., additional, Ramos-Cano, J., additional, Santos-Beltran, A., additional, and Gallegos-Orozco, V., additional
- Published
- 2017
- Full Text
- View/download PDF
22. SEM Study of Corrosion Deposits of Ni-Mn-Ga Fe Doped Shape Memory Alloys
- Author
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Sanchez-Carrillo, M., primary, Morales-Rodriguez, H., additional, Flores de los Rios, J. P., additional, Huape-Padilla, E., additional, Santos-Beltran, A., additional, and Gallegos-Orozco, V., additional
- Published
- 2017
- Full Text
- View/download PDF
23. An Evaluation of the Exposure in Nadir Observation of the JEM-EUSO Mission
- Author
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Adams Jr., J. H., Ahmad, S., Albert, J.-N., Allard, D., Ambrosio, M., Anchordoqui, L., Anzalone, A., Arai, Y., Aramo, C., Asano, K., Ave, M., Keilhauer, B., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kim, Sug-Whan, Kleifges, M., Klimov, P. A., Ko, S. H., Kolev, D., Kreykenbohm, I., Barrillon, P., Kudela, K., Kurihara, Y., Kuznetsov, E., La Rosa, G., Lee, J., Licandro, J., Lim, H., Lopez, F., Maccarone, M. C., Mannheim, K., Batsch, T., Marcelli, L., Marini, A., Martin-Chassard, G., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Maurissen, A., Medina-Tanco, G., Mernik, T., Bayer, J., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monnier-Ragaigne, D., Morales de los Rios, J. A., Mot, B., Murakami, T., Nagano, M., Nagata, M., Belenguer, T., Nagataki, S., Nakamura, T., Nam, J. W., Nam, S., Nam, K., Napolitano, T., Naumov, D., Neronov, A., Nomoto, K., Ogawa, T., Bellotti, R., Ohmori, H., Olinto, A. V., Orleanski, P., Osteria, G., Pacheco, N., Panasyuk, M. I., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Berlind, A. A., Paul, T., Pennypacker, C., Peter, T., Picozza, P., Pollini, A., Prieto, H., Reardon, P., Reina, M., Reyes, M., Ricci, M., Bertaina, M., Rodriguez, I., Frias, M. D. Rodriguez, Ronga, F., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Saez Cano, G., Saito, A., Biermann, P. L., Sakaki, N., Sakata, M., Salazar, H., Sanchez, S., Santangelo, Santiago Cruz, L., Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, H., Biktemerova, S., Sato, M., Schanz, T., Schieler, H., Scotti, V., Scuderi, M., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Blaksley, C., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec-Ozieblo, G., Silva Lopez, H. H., Sledd, J., Slominska, K., Sobey, A., Sugiyama, T., Brecki, J., Supanitsky, D., 鈴木, 睦, Szabelska, B., Szabelski, J., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Blin-Bondil, S., Takizawa, Y., Tenzer, C., Tibolla, O., Tkachev, L., Tomida, T., Tone, N., Trillaud, F., Tsenov, R., Tsuno, K., Tymieniecka, T., Blumer, J., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Valore, L., Vankova, G., Vigorito, C., Villasenor, L., von Ballmoos, P., Wada, S., Bobik, P., Watanabe, J., Watanabe, S., Watts Jr., J., Weber, M., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Bogomilov, M., Yamamoto, T., Yamamoto, Y., Yang, J., 矢野, 創, Yashin, I. V., Yonetoku, D., Yoshida, K., Yoshida, S., Young, R., Zamora, A., Bonamente, M., Zuccaro Marchi, A., Briggs, M. S., Briz, S., Bruno, A., Cafagna, F., Campana, D., Capdevielle, J.-N., Caruso, R., Casolino, M., Cassardo, C., Castellini, G., Catalano, O., Cellino, A., Chikawa, M., Christl, M. J., Connaughton, V., Cortes, J. F., Crawford, H. J., Cremonini, R., Csorna, S., D'Olivo, J. C., Dagoret-Campagne, S., de Castro, A. J., De Donato, C., de la Taille, C., del Peral, L., Dell'Oro, A., De Pascale, M. P., Di Martino, M., Distratis, G., Dupieux, M., Ebersoldt, A., Ebisuzaki, T., Engel, R., Falk, S., Fang, K., Fenu, F., Fernandez-Gomez, I., Ferrarese, S., Franceschi, A., Fujimoto, J., Galeotti, P., Garipov, G., Geary, J., Giaccari, U. G., Giraudo, G., Gonchar, M., Gonzalez Alvarado, C., Gorodetzky, P., Guarino, F., Guzman, A., Hachisu, Y., Harlov, B., Haungs, A., Hernandez Carretero, J., Higashide, K., Iguchi, T., Ikeda, Hirokazu, Inoue, N., Inoue, S., Insolia, A., Isgro, F., Itow, Y., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Suzuki, Makoto, Yano, Hajime, 池田, 博一, Adams Jr., J. H., Ahmad, S., Albert, J.-N., Allard, D., Ambrosio, M., Anchordoqui, L., Anzalone, A., Arai, Y., Aramo, C., Asano, K., Ave, M., Keilhauer, B., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kim, Sug-Whan, Kleifges, M., Klimov, P. A., Ko, S. H., Kolev, D., Kreykenbohm, I., Barrillon, P., Kudela, K., Kurihara, Y., Kuznetsov, E., La Rosa, G., Lee, J., Licandro, J., Lim, H., Lopez, F., Maccarone, M. C., Mannheim, K., Batsch, T., Marcelli, L., Marini, A., Martin-Chassard, G., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Maurissen, A., Medina-Tanco, G., Mernik, T., Bayer, J., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monnier-Ragaigne, D., Morales de los Rios, J. A., Mot, B., Murakami, T., Nagano, M., Nagata, M., Belenguer, T., Nagataki, S., Nakamura, T., Nam, J. W., Nam, S., Nam, K., Napolitano, T., Naumov, D., Neronov, A., Nomoto, K., Ogawa, T., Bellotti, R., Ohmori, H., Olinto, A. V., Orleanski, P., Osteria, G., Pacheco, N., Panasyuk, M. I., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Berlind, A. A., Paul, T., Pennypacker, C., Peter, T., Picozza, P., Pollini, A., Prieto, H., Reardon, P., Reina, M., Reyes, M., Ricci, M., Bertaina, M., Rodriguez, I., Frias, M. D. Rodriguez, Ronga, F., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Saez Cano, G., Saito, A., Biermann, P. L., Sakaki, N., Sakata, M., Salazar, H., Sanchez, S., Santangelo, Santiago Cruz, L., Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, H., Biktemerova, S., Sato, M., Schanz, T., Schieler, H., Scotti, V., Scuderi, M., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Blaksley, C., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec-Ozieblo, G., Silva Lopez, H. H., Sledd, J., Slominska, K., Sobey, A., Sugiyama, T., Brecki, J., Supanitsky, D., 鈴木, 睦, Szabelska, B., Szabelski, J., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Blin-Bondil, S., Takizawa, Y., Tenzer, C., Tibolla, O., Tkachev, L., Tomida, T., Tone, N., Trillaud, F., Tsenov, R., Tsuno, K., Tymieniecka, T., Blumer, J., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Valore, L., Vankova, G., Vigorito, C., Villasenor, L., von Ballmoos, P., Wada, S., Bobik, P., Watanabe, J., Watanabe, S., Watts Jr., J., Weber, M., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Bogomilov, M., Yamamoto, T., Yamamoto, Y., Yang, J., 矢野, 創, Yashin, I. V., Yonetoku, D., Yoshida, K., Yoshida, S., Young, R., Zamora, A., Bonamente, M., Zuccaro Marchi, A., Briggs, M. S., Briz, S., Bruno, A., Cafagna, F., Campana, D., Capdevielle, J.-N., Caruso, R., Casolino, M., Cassardo, C., Castellini, G., Catalano, O., Cellino, A., Chikawa, M., Christl, M. J., Connaughton, V., Cortes, J. F., Crawford, H. J., Cremonini, R., Csorna, S., D'Olivo, J. C., Dagoret-Campagne, S., de Castro, A. J., De Donato, C., de la Taille, C., del Peral, L., Dell'Oro, A., De Pascale, M. P., Di Martino, M., Distratis, G., Dupieux, M., Ebersoldt, A., Ebisuzaki, T., Engel, R., Falk, S., Fang, K., Fenu, F., Fernandez-Gomez, I., Ferrarese, S., Franceschi, A., Fujimoto, J., Galeotti, P., Garipov, G., Geary, J., Giaccari, U. G., Giraudo, G., Gonchar, M., Gonzalez Alvarado, C., Gorodetzky, P., Guarino, F., Guzman, A., Hachisu, Y., Harlov, B., Haungs, A., Hernandez Carretero, J., Higashide, K., Iguchi, T., Ikeda, Hirokazu, Inoue, N., Inoue, S., Insolia, A., Isgro, F., Itow, Y., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Suzuki, Makoto, Yano, Hajime, and 池田, 博一
- Abstract
著者人数: 261名, Accepted: 2013-01-14
- Published
- 2015
24. Parvovirus B19 infection: An unusual aetiology of anaemia
- Author
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Díez de los Ríos, J., Reynaga, E., and Badia, D.
- Published
- 2018
- Full Text
- View/download PDF
25. Infección por parvovirus B19: una inusual etiología de anemia
- Author
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Díez de los Ríos, J., Reynaga, E., and Badia, D.
- Published
- 2018
- Full Text
- View/download PDF
26. An evaluation of the exposure in nadir observation of the JEM-EUSO mission
- Author
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Adams, Jr. J. H., Ahmad, S., Albert, J.-N., Allard, D., Ambrosio, M., Anchordoqui, L., Anzalone, A., Arai, Y., Aramo, C., Asano, K., Ave, M., Keilhauer, B., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kim, Sug-Whan, Kleifges, M., Klimov, P. A., Ko, S. H., Kolev, D., Kreykenbohm, I., Barrillon, P., Kudela, K., Kurihara, Y., Kuznetsov, E., La, Rosa G., Lee, J., Licandro, J., Lim, H., Lopez, F., Maccarone, M. C., Mannheim, K., Batsch, T., Marcelli, L., Marini, A., Martin-Chassard, G., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Maurissen, A., Medina-Tanco, G., Mernik, T., Bayer, J., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monnier-Ragaigne, D., Morales, de los Rios J. A., Mot, B., Murakami, T., Nagano, M., Nagata, M., Belenguer, T., Nagataki, S., Nakamura, T., Nam, J. W., Nam, S., Nam, K., Napolitano, T., Naumov, D., Neronov, A., Nomoto, K., Ogawa, T., Bellotti, R., Ohmori, H., Olinto, A. V., Orleanski, P., Osteria, G., Pacheco, N., Panasyuk, M. I., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Berlind, A. A., Paul, T., Pennypacker, C., Peter, T., Picozza, P., Pollini, A., Prieto, H., Reardon, P., Reina, M., Reyes, M., Ricci, M., Bertaina, M., Rodriguez, I., Frias, M. D. Rodriguez, Ronga, F., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Saez, Cano G., Saito, A., Biermann, P. L., Sakaki, N., Sakata, M., Salazar, H., Sanchez, S., Santangelo, Santiago, Cruz L., Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, H., Biktemerova, S., Sato, M., Schanz, T., Schieler, H., Scotti, V., Scuderi, M., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Blaksley, C., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec-Ozieblo, G., Silva, Lopez H. H., Sledd, J., Slominska, K., Sobey, A., Sugiyama, T., Brecki, J., Supanitsky, D., Szabelska, B., Szabelski, J., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Blin-Bondil, S., Takizawa, Y., Tenzer, C., Tibolla, O., Tkachev, L., Tomida, T., Tone, N., Trillaud, F., Tsenov, R., Tsuno, K., Tymieniecka, T., Blumer, J., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Valore, L., Vankova, G., Vigorito, C., Villasenor, L., von, Ballmoos P., Wada, S., Bobik, P., Watanabe, J., Watanabe, S., Watts, Jr. J., Weber, M., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Bogomilov, M., Yamamoto, T., Yamamoto, Y., Yang, J., Yashin, I. V., Yonetoku, D., Yoshida, K., Yoshida, S., Young, R., Zamora, A., Bonamente, M., Zuccaro, Marchi A., Briggs, M. S., Briz, S., Bruno, A., Cafagna, F., Campana, D., Capdevielle, J.-N., Caruso, R., Casolino, M., Cassardo, C., Castellini, G., Catalano, O., Cellino, A., Chikawa, M., Christl, M. J., Connaughton, V., Cortes, J. F., Crawford, H. J., Cremonini, R., Csorna, S., D'Olivo, J. C., Dagoret-Campagne, S., de, Castro A. J., De, Donato C., de, la Taille C., del, Peral L., Dell'Oro, A., De, Pascale M. P., Di, Martino M., Distratis, G., Dupieux, M., Ebersoldt, A., Ebisuzaki, T., Engel, R., Falk, S., Fang, K., Fenu, F., Fernandez-Gomez, I., Ferrarese, S., Franceschi, A., Fujimoto, J., Galeotti, P., Garipov, G., Geary, J., Giaccari, U. G., Giraudo, G., Gonchar, M., Gonzalez, Alvarado C., Gorodetzky, P., Guarino, F., Guzman, A., Hachisu, Y., Harlov, B., Haungs, A., Hernandez, Carretero J., Higashide, K., Iguchi, T., Inoue, N., Inoue, S., Insolia, A., Isgro, F., Itow, Y., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Ikeda, Hirokazu, Suzuki, Makoto, Yano, Hajime, JEM-EUSO, Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), APC - Astrophysique des Hautes Energies (APC - AHE), AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), APC - Neutrinos, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, APC - THEORIE, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut für theoretische Physik, Universität Hamburg (UHH)-Universität Hamburg (UHH), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut für theoretische Physik, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)-AstroParticule et Cosmologie (APC (UMR_7164)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut für theoretische Physik, Guarino, F., Isgro', F., Scotti, V., Valore, L., and JEM-EUSO Collaboration, The
- Subjects
[PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE] ,[PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM] ,Ciencias Físicas ,media_common.quotation_subject ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Cosmic ray ,01 natural sciences ,purl.org/becyt/ford/1 [https] ,Atmosphere ,Observatory ,0103 physical sciences ,International Space Station ,Nadir ,Ultraviolet light ,Extensive air showers ,extensive air showers ,space-based experiment ,010303 astronomy & astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,Remote sensing ,media_common ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,010308 nuclear & particles physics ,[SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE] ,Astrophysics::Instrumentation and Methods for Astrophysics ,Astronomy ,Astronomy and Astrophysics ,purl.org/becyt/ford/1.3 [https] ,Universe ,[SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM] ,Astronomía ,Ultra High Energy Cosmic Rays ,Space-based experiment ,Physics::Space Physics ,JEM-EUSO mission ,Satellite ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics ,CIENCIAS NATURALES Y EXACTAS - Abstract
著者人数: 261名, Accepted: 2013-01-14, 資料番号: SA1004526000
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- 2013
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27. Celulitis por Streptococcus pneumoniae
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Díez de los Ríos, J., Isernia, V., and Navarro, M.
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- 2017
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28. An evaluation of the exposure in nadir observation of the JEM-EUSO mission
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Adams, J., Ahmad, S., Albert, J., Allard, D., Ambrosio, M., Anchordoqui, L., Anzalone, A., Arai, Y., Aramo, C., Asano, K., Ave, M., Barrillon, P., Batsch, T., Bayer, J., Belenguer, T., Bellotti, R., Berlind, A., Bertaina, M., Biermann, P., Biktemerova, S., Blaksley, C., Blecki, J., Blin-Bondil, S., Blümer, J., Bobík, P., Bogomilov, M., Bonamente, M., Briggs, M., Briz, S., Bruno, A., Cafagna, F., Campana, D., Capdevielle, J., Caruso, R., Casolino, M., Cassardo, C., Castellini, G., Catalano, O., Cellino, A., Chikawa, M., Christl, M., Connaughton, V., Cortés, J., Crawford, H., Cremonini, R., Csorna, S., D'Olivo, J., Dagoret-Campagne, S., De Castro, A., De Donato, C., De La Taille, C., Del Peral, L., Dell'Oro, A., De Pascale, M., Di Martino, M., Distratis, G., Dupieux, M., Ebersoldt, A., Ebisuzaki, T., Engel, R., Falk, S., Fang, K., Fenu, F., Fernández-Gómez, I., Ferrarese, S., Franceschi, E., Fujimoto, M., Galeotti, P., Garipov, G., Geary, J., Giaccari, U., Giraudo, G., Gonchar, M., González Alvarado, C., Gorodetzky, P., Guarino, F., Guzmán, A., Hachisu, Y., Harlov, B., Haungs, A., Hernández Carretero, J., Higashide, K., Iguchi, T., Ikeda, H., Inoue, N., Inoue, S., Insolia, A., Isgrò, F., Itow, Y., Joven, E., Judd, E., Jung, A., Kajino, F., Kajino, T., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawahata, K., Kawasaki, Y., Keilhauer, B., Khrenov, B., Kim, J., Kim, S., Kleifges, M., Klimov, P., Ko, S., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kuznetsov, E., La Rosa, G., Lee, J., Licandro, J., Lim, H., López, F., Maccarone, M., Mannheim, K., Marcelli, L., Marini, A., Martin-Chassard, G., Martínez, O., Masciantonio, G., Mase, K., Matev, R., Maurissen, A., Medina-Tanco, G., Mernik, T., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monnier Ragaigne, D., Morales De Los Rios, J., Mot, B., Murakami, T., Nagano, M., Nagata, M., Nagataki, S., Nakamura, T., Nam, J., Nam, S., Nam, K., Napolitano, T., Naumov, D., Neronov, A., Nomoto, K., Ogawa, T., Ohmori, H., Olinto, A., Orleanski, P., Osteria, G., Pacheco, N., Panasyuk, M., Parizot, E., Park, I., Pastircák, B., Patzak, T., Paul, T., Pennypacker, C., Peter, T., Picozza, P., Pollini, A., Prieto, H., Reardon, P., Reina, M., Reyes, M., Ricci, M., Rodríguez, I., Rodríguez Frías, M., Ronga, F., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M., Sáez Cano, G., Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sánchez, S., Santangelo, A., Santiago Crúz, L., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, V., Scuderi, M., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H., Shinozaki, K., Shirahama, T., Siemieniec-Ozi?blo, G., Silva López, H., Sledd, J., Slominska, K., Sobey, A., Sugiyama, T., Supanitsky, A., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, F., Tajima, N., Tajima., T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Tenzer, C., Tibolla, Omar, Tkachev, L., Tomida, T., Tone, N., Trillaud, F., Tsenov, R., Tsuno, K., Tymieniecka, T., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J., Vallania, P., Valore, L., Vankova, G., Vigorito, C., Villaseñor, L., Von Ballmoos, P., Wada, S., Watanabe, J., Watanabe, S., Watts, J., Weber, M., Weiler, T., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin., I., Yonetoku, D., Yoshida, K., Yoshida, S., Young, R., Zamora, A., Zuccaro Marchi, A., Adams, J., Ahmad, S., Albert, J., Allard, D., Ambrosio, M., Anchordoqui, L., Anzalone, A., Arai, Y., Aramo, C., Asano, K., Ave, M., Barrillon, P., Batsch, T., Bayer, J., Belenguer, T., Bellotti, R., Berlind, A., Bertaina, M., Biermann, P., Biktemerova, S., Blaksley, C., Blecki, J., Blin-Bondil, S., Blümer, J., Bobík, P., Bogomilov, M., Bonamente, M., Briggs, M., Briz, S., Bruno, A., Cafagna, F., Campana, D., Capdevielle, J., Caruso, R., Casolino, M., Cassardo, C., Castellini, G., Catalano, O., Cellino, A., Chikawa, M., Christl, M., Connaughton, V., Cortés, J., Crawford, H., Cremonini, R., Csorna, S., D'Olivo, J., Dagoret-Campagne, S., De Castro, A., De Donato, C., De La Taille, C., Del Peral, L., Dell'Oro, A., De Pascale, M., Di Martino, M., Distratis, G., Dupieux, M., Ebersoldt, A., Ebisuzaki, T., Engel, R., Falk, S., Fang, K., Fenu, F., Fernández-Gómez, I., Ferrarese, S., Franceschi, E., Fujimoto, M., Galeotti, P., Garipov, G., Geary, J., Giaccari, U., Giraudo, G., Gonchar, M., González Alvarado, C., Gorodetzky, P., Guarino, F., Guzmán, A., Hachisu, Y., Harlov, B., Haungs, A., Hernández Carretero, J., Higashide, K., Iguchi, T., Ikeda, H., Inoue, N., Inoue, S., Insolia, A., Isgrò, F., Itow, Y., Joven, E., Judd, E., Jung, A., Kajino, F., Kajino, T., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawahata, K., Kawasaki, Y., Keilhauer, B., Khrenov, B., Kim, J., Kim, S., Kleifges, M., Klimov, P., Ko, S., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kuznetsov, E., La Rosa, G., Lee, J., Licandro, J., Lim, H., López, F., Maccarone, M., Mannheim, K., Marcelli, L., Marini, A., Martin-Chassard, G., Martínez, O., Masciantonio, G., Mase, K., Matev, R., Maurissen, A., Medina-Tanco, G., Mernik, T., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monnier Ragaigne, D., Morales De Los Rios, J., Mot, B., Murakami, T., Nagano, M., Nagata, M., Nagataki, S., Nakamura, T., Nam, J., Nam, S., Nam, K., Napolitano, T., Naumov, D., Neronov, A., Nomoto, K., Ogawa, T., Ohmori, H., Olinto, A., Orleanski, P., Osteria, G., Pacheco, N., Panasyuk, M., Parizot, E., Park, I., Pastircák, B., Patzak, T., Paul, T., Pennypacker, C., Peter, T., Picozza, P., Pollini, A., Prieto, H., Reardon, P., Reina, M., Reyes, M., Ricci, M., Rodríguez, I., Rodríguez Frías, M., Ronga, F., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M., Sáez Cano, G., Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sánchez, S., Santangelo, A., Santiago Crúz, L., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, V., Scuderi, M., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H., Shinozaki, K., Shirahama, T., Siemieniec-Ozi?blo, G., Silva López, H., Sledd, J., Slominska, K., Sobey, A., Sugiyama, T., Supanitsky, A., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, F., Tajima, N., Tajima., T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Tenzer, C., Tibolla, Omar, Tkachev, L., Tomida, T., Tone, N., Trillaud, F., Tsenov, R., Tsuno, K., Tymieniecka, T., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J., Vallania, P., Valore, L., Vankova, G., Vigorito, C., Villaseñor, L., Von Ballmoos, P., Wada, S., Watanabe, J., Watanabe, S., Watts, J., Weber, M., Weiler, T., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin., I., Yonetoku, D., Yoshida, K., Yoshida, S., Young, R., Zamora, A., and Zuccaro Marchi, A.
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- 2013
29. Null space based behavior control applied to robot formation.
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Quintana-Carapia, Gustavo, Benitez-Read, Jorge S., and Segovia-De-Los-Rios, J. Armando
- Abstract
This paper presents the null space based behavioral control method applied to the formation of a mobile robot team. This method has been used in redundant manipulators to obtain the joint parameters (joint space) based on Cartesian coordinates. New task functions are introduced to obtain a predefined robot formation. As in redundant manipulators, the inverse kinematics of a group of mobile robots admits infinite solutions. The redundancy is exploited to obtain additional maneuverability in terms of configuration and interaction with the workspace. [ABSTRACT FROM PUBLISHER]
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- 2012
30. Changes of the Renin Aldosterone System and pattern of sodium excretion after orthotopic liver transplantation
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de los Rios, J, primary
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- 1993
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31. Microdiálisis de alta resolución. Aspectos metodológicos y aplicación al estudio de la respuesta inflamatoria cerebral.
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De Los Rios, J. A., Sahuquillo, J., Merino, M. A., Poca, M. A., and Expósito, L.
- Abstract
Copyright of Neurocirugía is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2009
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32. [Monoclonal gammopathy in rheumatoid arthritis]
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Gabriel Herrero-Beaumont, Morales Piga A, Fernández Domínguez E, Ortíz Masllorens F, Egido de los Rios J, Jl, Póstigo Alvarez, and Fernández del Vallado P
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Adult ,Arthritis, Rheumatoid ,Male ,Hypergammaglobulinemia ,Humans ,Immunoglobulins ,Female ,Middle Aged ,Immunoelectrophoresis - Published
- 1980
33. The JEM-EUSO Mission: Contributions to the ICRC 2013
- Author
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Adams, JEM EUSO Collaboration (. J. H., J. r., Polytech, S. Ahmad (. E. c., Palaiseau, Albert, J. N., Allard, D., Anchordoqui, L., Andreev, V., Anzalone, A., Arai, Y., Asano, K., Ave Pernas, M., Barrillon, P., Batsch, T., Bayer, J., Belenguer, T., Bellotti, R., Belov, K., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Blaksley, C., Blanc, N., Blecki, J., Polytech, S. Blin Bondil (. E. c., Blumer, J., Bobik, P., Bogomilov, M., Bonamente, M., Briggs, M. S., Briz, S., Bruno, A., Cafagna, F., Campana, D., Capdevielle, J. N., Caruso, Rossella, Casolino, M., Cassardo, C., Castellini, G., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Christl, M. J., Cline, D., Connaughton, V., Conti, L., Cordero, G., Crawford, H. J., Cremonini, R., Csorna, S., Dagoret Campagne, S., De Castro, A. J., De Donato, C., Polytech, C. de la Taille (. E. c., De Santis, C., del Peral, L., Dell'Oro, A., De Simone, N., Di Martino, M., Distratis, G., Polytech, F. Dulucq (. E. c., Dupieux, M., Ebersoldt, A., Ebisuzaki, T., Engel, R., Falk, S., Fang, K., Fenu, F., Fernandez Gomez, I., Ferrarese, S., Finco, D., Flamini, M., Fornaro, C., Franceschi, A., Fujimoto, J., Fukushima, M., Galeotti, P., Garipov, G., Geary, J., Gelmini, G., Giraudo, G., Gonchar, M., Gonzalez Alvarado, C., Gorodetzky, P., Guarino, F., Guzman, A., Hachisu, Y., Harlov, B., Haungs, A., Hernandez Carretero, J., Higashide, K., Ikeda, D., Ikeda, H., Inoue, N., Inoue, S., Insolia, A., Isgro, F., Itow, Y., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Karus, M., Katahira, K., Kawai, K., Kawasaki, Y., Keilhauer, B., Khrenov, B. A., Jeong Sook Kim, Soon Wook Kim, Sug Whan Kim, Kleifges, M., Klimov, P. A., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lacombe, M., Lachaud, C., Lee, J., Licandro, J., Lim, H., Lopez, F., Maccarone, M. C., Mannheim, K., Maravilla, D., Marcelli, L., Marini, A., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Medina Tanco, G., Mernik, T., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monaco, A., Monnier Ragaigne, D., Morales de los Rios, J. A., Moretto, C., Morozenko, V. S., Mot, B., Murakami, T., Nagano, M., Nagata, M., Nagataki, S., Nakamura, T., Napolitano, T., Naumov, D., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleanski, P., Osteria, G., Panasyuk, M. I., Parizot, E., Park, I. H., Park, H. W., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Perez Cano, S., Peter, T., Picozza, P., Pierog, T., Piotrowski, L. W., Piraino, S., Plebaniak, Z., Pollini, A., Prat, P., Prevot, G., Prieto, H., Putis, M., Reardon, P., Reyes, M., Ricci, M., Rodriguez, I., Rodriguez Frias, M. D., Ronga, F., Roth, M., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Saez Cano, G., Sagawa, H., Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sanchez, S., Santangelo, A., Santiago Cruz, L., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, V., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec Ozieblo, G., Silva Lopez, H. H., Sledd, J., Slominska, K., Sobey, A., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Tenzer, C., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Trillaud, F., Tsenov, R., Tsunesada, Y., Tsuno, K., Tymieniecka, T., Uchihori, Y., Unger, M., Vaduvescu, O., Valdes Galicia, J. F., Vallania, P., Valore, L., Vankova, G., Vigorito, C., Villasenor, L., von Ballmoos, P., Wada, S., Watanabe, J., Watanabe, S., J. Watts J. r., Weber, M., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Z. W. l., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, K., Yoshida, S., Young, R., Zotov, M. Y. u., and Zuccaro Marchi, A.
34. Corrosion study of Fe-Al intermetallic alloys in simulated acid rain
- Author
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Engelbert Huape Padilla, Sánchez-Carrillo, M., Flores-De Los Rios, J. P., Espinosa-Medina, M. A., Bautista-Margulis, R. G., Ferrer-Sánchez, M. I., Carbajal-De La Torre, G., Bejar-Gómez, L., Chacón-Nava, J. G., and Martínez-Villafañe, A.
35. Identification of cracks and temperature in restrained beams using dynamic stiffness matrix
- Author
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De Los Rios, J., Kennedy, David, De Los Rios, J., and Kennedy, David
36. Identification of cracks and temperature in restrained beams using dynamic stiffness matrix
- Author
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De Los Rios, J., Kennedy, David, De Los Rios, J., and Kennedy, David
37. Immunity to hepatitis-B in a haemodialysis unit
- Author
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De la Concha, E, primary, De los Rios, J, additional, Masllorens, F, additional, and Avendano, L, additional
- Published
- 1975
- Full Text
- View/download PDF
38. Hypercalcaemia, Hypophosphataemia, and Inability to Excrete Hydrogen Ions
- Author
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Arcila, H., primary, de Los Rios, J. C., additional, Van Dyck, R., additional, and Zorrilla, E., additional
- Published
- 1972
- Full Text
- View/download PDF
39. Ultra-violet imaging of the night-time earth by EUSO-Balloon towards space-based ultra-high energy cosmic ray observations
- Author
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A. Anzalone, Toshiyuki Nonaka, Javier Licandro, K. Benmessai, B. Beldjilali, E. Kuznetsov, N. Blanc, J. L. Marcos, G. Puehlhofer, T. Djemil, Toshiki Tajima, Giuseppe Giraudo, A. Kedadra, K. S. Caballero, M. Di Martino, M. Ave Pernas, S. Blin-Bondil, G. Cordero, H. Khales, L. Allen, P. Baragatti, A. Marini, Hitoshi Ohmori, Alberto Cellino, Hiroyuki Sagawa, I. Dutan, Yoshiya Kawasaki, T. Napolitano, malek mastafa, B. A. Khrenov, Sebastián Franchini, T. Paul, G. Cotto, C. De Donato, I. Stan, P. Gorodetzky, A. Pagliaro, S. Jeong, J. Watanabe, Piergiorgio Picozza, D. Allard, M. Suzuki, L. López Campano, Soon-Wook Kim, J. Rabanal, G. Osteria, Guillaume Prévôt, O. Larsson, L. R. Wiencke, A. Ebersoldt, Yoshio Arai, Francesca Bisconti, J. Hernández Carretero, Katsuhiko Tsuno, I. Kreykenbohm, D. Kolev, A. Radu, N. Tajima, M. Takeda, Shigehiro Nagataki, A. Guzmán, C. Lachaud, Christer Fuglesang, José Meseguer, A. Menshikov, Osvaldo Catalano, Silvia Ferrarese, R. Greg, J. Mimouni, C. González Alvarado, M. E. Bertaina, Valentina Scotti, M. Bogomilov, N. Mebarki, Y. Martín, C. De Santis, Ken'ichi Nomoto, G. Chiritoi, R. Attallah, N. Tone, K. Martens, Valerie Connaughton, Angel Sanz-Andrés, L. Marcelli, G. Masciantonio, I. S. Zgura, J. Tubbs, Hirohiko M. Shimizu, Austin Cummings, M. Wille, H. Krantz, F. Kajino, A. Jung, Y. Tsunesada, Y. Uchihori, A. La Barbera, H. Lahmar, Daisuke Yonetoku, G. Medina-Tanco, Mohammed Bakiri, Maciej Rybczyński, K. Kudela, J. F. Krizmanic, J. Genci, Konstantin Belov, F.J. Ronga, Yoshimasa Kurihara, C. Moretto, A. Diaz Damian, Jin Yong Lee, H. Schieler, Alfonso Monaco, Antonella Castellina, Mitsuteru Sato, N. Inoue, L. del Peral, A. Franceschi, E. Parizot, Z. Polonsky, Humberto Ibarguen Salazar, T. Shirahama, T. Jammer, Santiago Pindado, Junpei Fujimoto, G. Abdellaoui, L. Villaseñor, Y. Hachisu, G. Roudil, H. Tokuno, Pavol Bobik, F. Perfetto, Hajime Yano, O. Martinez, Bruno Spataro, Tokonatsu Yamamoto, S. Kalli, M. Yu. Zotov, John N. Matthews, Katsuaki Asano, Estíbaliz Gascón, B. Harlov, Carlo Vigorito, Roberto Bellotti, K. Mase, R. Nava, B. Pastirčák, J. Watts, E. Bozzo, S. Turriziani, Toshikazu Ebisuzaki, M. A. Mendoza, Pierre Barrillon, S. Briz, Eduardo García-Ortega, M. Sanz Palomino, E. M. Popescu, Barbara Szabelska, W. Painter, James H. Adams, Sergei A. Sharakin, Rossella Caruso, M. Vrabel, P. Prat, Francesco Isgrò, S. Bartocci, M. Traïche, Josef Jochum, Piero Vallania, M. D. Sabau, Z. Sahnoune, J. A. Morales de los Ríos, T. Peter, S. Naitamor, R. Tsenov, Tomás Belenguer, J. C. Sanchez Balanzar, Gustavo Alonso, F. Cafagna, W. Marszał, Satoshi Wada, Toshitaka Kajino, Piotr Orleanski, J.N. Capdevielle, R. Young, D. Campana, F. Lakhdari, T. Ogawa, W. Hidber Cruz, Thomas Schanz, Daisuke Ikeda, E. Joven, Inkyu Park, N. Belkhalfa, Francesca Capel, P. Galeotti, A. Pollini, Pavel Klimov, B. Panico, M. C. Talai, S. Bacholle, A. J. de Castro, M. Putis, M. Haiduc, Lech Wiktor Piotrowski, Susumu Inoue, S. S. Meyer, Francesco Fenu, S. B. Thomas, H. Miyamoto, Livio Conti, Angela V. Olinto, H. Attoui, Ovidiu Vaduvescu, C. Tenzer, T. Sugiyama, J. Błȩcki, Sergio Fernández-González, R. Matev, J. F. Valdés-Galicia, J. Bayer, Claudio Cassardo, Andrea Santangelo, A. Neronov, L. G. Tkachev, Simona Toscano, A. Weindl, A. Zuccaro Marchi, M. C. Maccarone, M. Fouka, S. Mackovjak, S. Yoshida, J. Szabelski, L. Caramete, Jörn Wilms, Takayuki Tomida, Dmitri Semikoz, C. de la Taille, Naoto Sakaki, C. Catalano, G. Vankova, D. Supanitsky, Mark Christl, O. Tibolla, O. A. Saprykin, Yoshitaka Itow, K. Katahira, A. Belov, H. Prieto, A. Caramete, R. Cremonini, Andrés Merino, Hajime Takami, F. López, M. Rezazadeh, S. Selmane, D. Maravilla, S. Biktemerova, Masaki Fukushima, E. G. Judd, Isabel Pérez-Grande, Shinsuke Abe, P. Carlson, F. Sarazin, A. Haungs, S. Piraino, Kenji Shinozaki, Zbigniew Wlodarczyk, H. J. Crawford, Gali Garipov, Marc Weber, R. Weigand Muñoz, A. Kusenko, S. Pliego, M. Martucci, Shoichi Ogio, Y. Karadzhov, M. Flamini, J. Yang, B. Vlcek, Y. Takizawa, Amine Ahriche, L. Placidi, P. L. Biermann, M. D. Rodríguez Frías, M. Kleifges, I. Rusinov, Z. Plebaniak, I. V. Yashin, K. Kawai, Michiyuki Chikawa, Marcos Reyes, Akinori Saito, S. E. Csorna, Johannes Eser, M. Serra, Luis A. Anchordoqui, A. Bruno, Jeong-Sook Kim, I. Kaneko, T. Patzak, Yoshihiko Mizumoto, J. Karczmarczyk, G. Sáez Cano, Fausto Guarino, P. von Ballmoos, M. Ricci, S. Dagoret-Campagne, Yukihiro Takahashi, José Luis Sánchez, Marco Casolino, Claudio Fornaro, Mikhail Panasyuk, Ralph Engel, Takahiro Fujii, M. Mahdi, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Organisation de Micro-Électronique Générale Avancée (OMEGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Abdellaoui, G., Abe, S., Adams, J. H., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Ave Pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Blecki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Briz, S., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J. -N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Cummings, A., Dagoret-Campagne, S., de Castro, A. J., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Diaz Damian, A., Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernandez-Gonzalez, S., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., Garcia-Ortega, E., Garipov, G., Gascon, E., Genci, J., Giraudo, G., Gonzalez Alvarado, C., Gorodetzky, P., Greg, R., Guarino, F., Guzman, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernandez Carretero, J., Hidber Cruz, W., Ikeda, D., Inoue, N., Inoue, S., Isgro, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, J. -S., Kim, S. -W., Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Krizmanic, J. F., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., Lopez Campano, L., Lopez, F., Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Marszal, W., Martens, K., Martin, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Mastafa, M., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Mendoza, M. A., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Morales de los Rios, J. A., Moretto, C., Nagataki, S., Naitamor, S., Napolitano, T., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleanski, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, Beatrice, Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Perez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonsky, Z., Popescu, E. M., Prat, P., Prevot, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Rodriguez Frias, M. D., Ronga, F., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Saez Cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sanchez Balanzar, J. C., Sanchez, J. L., Santangelo, A., Sanz-Andres, A., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shinozaki, K., Shirahama, T., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traiche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villasenor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts, J., Weber, M., Weigand Munoz, R., Weindl, A., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Y., Zuccaro Marchi, A., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)
- Subjects
lens ,air ,media_common.quotation_subject ,tube ,JEM-EUSO ,Extensive air shower ,Airglow ,EUSO-Balloon ,Ultra-high energy cosmic ray ,7. Clean energy ,01 natural sciences ,detector: fluorescence ,Aeronáutica ,pixel ,0103 physical sciences ,ultraviolet ,Ultra-high-energy cosmic ray ,cosmic radiation: UHE ,backscatter ,010303 astronomy & astrophysics ,particle source ,Astrophysique ,media_common ,Physics ,COSMIC cancer database ,showers: atmosphere ,Settore FIS/05 ,010308 nuclear & particles physics ,background ,photon ,Astronomy ,imaging ,Astronomy and Astrophysics ,Astronomie ,Photon counting ,Universe ,observatory ,Pathfinder ,Refracting telescope ,trajectory ,Trajectory ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,satellite: orbit - Abstract
The JEM-EUSO (Joint Experiment Missions for the Extreme Universe Space Observatory) program aims at developing Ultra-Violet (UV) fluorescence telescopes for efficient detections of Extensive Air Showers (EASs) induced by Ultra-High Energy Cosmic Rays (UHECRs) from satellite orbit. In order to demonstrate key technologies for JEM-EUSO, we constructed the EUSO-Balloon instrument that consists of a ∼1 m 2 refractive telescope with two Fresnel lenses and an array of multi-anode photo-multiplier tubes at the focus. Distinguishing it from the former balloon-borne experiments, EUSO-Balloon has the capabilities of single photon counting with a gate time of 2.3 µs and of imaging with a total of 2304 pixels. As a pathfinder mission, the instrument was launched for an 8 h stratospheric flight on a moonless night in August 2014 over Timmins, Canada. In this work, we analyze the count rates over ∼2.5 h intervals. The measurements are of diffuse light, e.g. of airglow emission, back-scattered from the Earth's atmosphere as well as artificial light sources. Count rates from such diffuse light are a background for EAS detections in future missions and relevant factor for the analysis of EAS events. We also obtain the geographical distribution of the count rates over a ∼780 km 2 area along the balloon trajectory. In developed areas, light sources such as the airport, mines, and factories are clearly identified. This demonstrates the correct location of signals that will be required for the EAS analysis in future missions. Although a precise determination of count rates is relevant for the existing instruments, the absolute intensity of diffuse light is deduced for the limited conditions by assuming spectra models and considering simulations of the instrument response. Based on the study of diffuse light by EUSO-Balloon, we also discuss the implications for coming pathfinders and future space-based UHECR observation missions., 0, SCOPUS: ar.j, info:eu-repo/semantics/published
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- 2019
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40. SUCCESSFUL PREGNANCY AND ADVANCED RENAL FAILURE
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Egido de los Ríos, J., Plaza Perez, J.J., Casado Pérez, S., and Avendano, L.Hernando
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- 1976
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41. Potential of the atmospheric monitoring system of JEM-EUSO mission
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Wada, S., Ebisuzaki, T., Ogawa, T., Sato, M., Peter, T., Mitev, V., Matthey, R., Anna Anzalone, Isgrò, F., Tegolo, D., Colombo, E., Morales Los Rios, J. A., Rodriguez Frias, M. D., Il, P., Shinwoo, N., Jae, P., Wada, S., Ebisuzaki, T., Ogawa, T., Sato, M., Peter, T., Mitev, V., Matthey, R., Anzalone, A., Isgrò, F., Tegolo, D., Colombo, E., Morales de los Rios, J., Rodriguez Frias, M., Il, P., Shinwoo, N., and Jae, P.
- Subjects
Nuclear and High Energy Physics - Abstract
The existance of high energy particles with energies >1020 eV in the space is a basic problem in fundermental physics, because it means a violation of the GZK theoretical limitation. JEM-EUSO will try to detect such high energy particles in the space by the oprical fluorescence from the high energy paticles incident to the atmosphere. For caliblation of the optical background an atmospheric monitoring system consisting of a spaceborne lidar with an ultraviolet pulsed laser and an IR camera will be used. The IR camera takes images at suitable time intervals, monitoring the cloud cover in the whole field of view (FoV) of the telescope. Moreover stereo images are also taken to retrieve pixel by pixel the height of the cloud-top. The ultraviolet lidar measures the height of surface of clouds with the 30 m resolution. From these measuremnts we obtain a 3 dimentional map of clouds. The laser specifications are 20mJ/pulses at 355nm 20Hz rate, single longitudinal mode, and M 2
- Published
- 2009
42. Population Pharmacokinetics of Delamanid and its Main Metabolite DM-6705 in Drug-Resistant Tuberculosis Patients Receiving Delamanid Alone or Coadministered with Bedaquiline.
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Tanneau L, Karlsson MO, Diacon AH, Shenje J, De Los Rios J, Wiesner L, Upton CM, Dooley KE, Maartens G, and Svensson EM
- Subjects
- Adult, Albumins, Antitubercular Agents, Diarylquinolines, Humans, Oxazoles, HIV Infections drug therapy, Nitroimidazoles pharmacokinetics, Nitroimidazoles therapeutic use, Tuberculosis, Multidrug-Resistant drug therapy
- Abstract
Background and Objective: Delamanid is a nitroimidazole, a novel class of drug for treating tuberculosis, and is primarily metabolized by albumin into the metabolite DM-6705. The aims of this analysis were to develop a population pharmacokinetic (PK) model to characterize the concentration-time course of delamanid and DM-6705 in adults with drug-resistant tuberculosis and to explore a potential drug-drug interaction with bedaquiline when coadministered., Methods: Delamanid and DM-6705 concentrations after oral administration, from 52 participants (of whom 26 took bedaquiline concurrently and 20 were HIV-1 positive) enrolled in the DELIBERATE trial were analyzed using nonlinear mixed-effects modeling., Results: Delamanid PK were described by a one-compartment disposition model with transit compartment absorption (mean absorption time of 1.45 h [95% confidence interval 0.501-2.20]) and linear elimination, while the PK of DM-6705 metabolite were described by a one-compartment disposition model with delamanid clearance as input and linear elimination. Predicted terminal half-life values for delamanid and DM-6705 were 15.1 h and 7.8 days, respectively. The impact of plasma albumin concentrations on delamanid metabolism was not significant. Bedaquiline coadministration did not affect delamanid PK. Other than allometric scaling with body weight, no patients' demographics were significant (including HIV)., Conclusions: This is the first joint PK model of delamanid and its DM-6705 metabolite. As such, it can be utilized in future exposure-response or exposure-safety analyses. Importantly, albumin concentrations, bedaquiline coadministration, and HIV co-infection (dolutegravir coadministration) did not have an effect on delamanid and DM-6705 PK., (© 2022. The Author(s).)
- Published
- 2022
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43. Acute lymphoblastic leukemia-secreted miRNAs induce a proinflammatory microenvironment and promote the activation of hematopoietic progenitors.
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Rios de Los Rios J, Enciso J, Vilchis-Ordoñez A, Vázquez-Ramírez R, Ramirez-Ramirez D, Balandrán JC, Rodríguez-Martínez A, Ruiz-Tachiquín M, Pompa-Mera E, Mendoza L, Pedraza-Alva G, Mayani H, Fabbri M, and Pelayo R
- Subjects
- Bone Marrow pathology, Humans, Toll-Like Receptor 8 metabolism, Tumor Microenvironment, MicroRNAs genetics, MicroRNAs metabolism, Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology
- Abstract
Leukemogenesis is proposed to result from the continuous interplay between inducive bone marrow (BM) microenvironments and malignant precursor cells. Recent findings point toward an abnormal production of proinflammatory mediators within the BM from acute lymphoblastic leukemia (ALL) patients, although the mechanism underlying this phenomenon is uncertain. Here, we have identified 3 miRNAs, miR-146a-5p, miR-181b-5p, and miR-199b-3p, as potential candidates for TLR8 ligation, which are overexpressed in ALL and show agonist functional binding. When purified from ALL exosomes, they demonstrated their capacity of inducing cytokine production by both, hematopoietic and stromal BM cells. Of note, the exposure of BM cells from ALL patients to the proinflammatory milieu resulting from these miRNAs agonist activity revealed the proliferation of normal progenitors, while poor effects were recorded in the leukemic counterpart. The unconventional roles of the tumor-secreted miRNAs as TLR8 agonist ligands may provide a novel mechanism contributing a tumor-microenvironment feedback loop by switching on proinflammatory pathways that further activate normal hematopoietic precursors and support ALL progression. Secreted B-ALL TLR8-agonist miRNAs are involved in the promotion of proinflammatory microenvironments that target normal hematopoietic cells. B-lineage ALL cells secrete exosomes containing miRNAs endowed with the ability of functionally binding TLR8 in hematopoietic and BM mesenchymal stromal cells. Upon TLR8 signaling, the activation of the NF-kB pathway induces secretion of proinflammatory cytokines that, in turn, promotes cell proliferation in early hematopoietic cell populations, driving a tumor-microenvironment-hematopoietic activation feedback loop that may reduce the normal hematopoietic stem and progenitor cell compartment and facilitate cancer progression., (©2022 Society for Leukocyte Biology.)
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- 2022
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44. QT effects of bedaquiline, delamanid, or both in patients with rifampicin-resistant tuberculosis: a phase 2, open-label, randomised, controlled trial.
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Dooley KE, Rosenkranz SL, Conradie F, Moran L, Hafner R, von Groote-Bidlingmaier F, Lama JR, Shenje J, De Los Rios J, Comins K, Morganroth J, Diacon AH, Cramer YS, Donahue K, and Maartens G
- Subjects
- Adult, Electrocardiography drug effects, Female, Humans, Male, Peru, Rifampin, South Africa, Treatment Outcome, Antitubercular Agents therapeutic use, Diarylquinolines therapeutic use, Drug Therapy, Combination, Nitroimidazoles therapeutic use, Oxazoles therapeutic use, Tuberculosis, Multidrug-Resistant drug therapy
- Abstract
Background: Bedaquiline and delamanid are the first drugs of new classes registered for tuberculosis treatment in 40 years. Each can prolong the QTc interval, with maximum effects occurring weeks after drug initiation. The cardiac safety and microbiological activity of these drugs when co-administered are not well-established. Our aim was to characterise the effects of bedaquiline, delamanid, or both on the QTc interval, longitudinally over 6 months of multidrug treatment, among patients with multidrug-resistant or rifampicin-resistant tuberculosis taking multidrug background therapy., Methods: ACTG A5343 is a phase 2, open-label, randomised, controlled trial in which adults with multidrug-resistant or rifampicin-resistant tuberculosis receiving multidrug background treatment were randomly assigned 1:1:1 by centrally, computer-generated randomisation, by means of permuted blocks to receive bedaquiline, delamanid, or both for 24 weeks. Participants were enrolled at TASK in Cape Town and the South African Tuberculosis Vaccine Initiative in Worcester, both in South Africa, and Hospital Maria Auxiliadora in Peru. Individuals with QTc greater than 450 ms were excluded. HIV-positive participants received dolutegravir-based antiretroviral therapy. Clofazimine was disallowed, and levofloxacin replaced moxifloxacin. ECG in triplicate and sputum cultures were done fortnightly. The primary endpoint was mean QTcF change from baseline (averaged over weeks 8-24); cumulative culture conversation at week 8-24 was an exploratory endpoint. Analyses included all participants who initiated study tuberculosis treatment (modified intention-to-treat population). This trial is registered with ClinicalTrials.gov, NCT02583048 and is ongoing., Findings: Between Aug 26, 2016 and July 13, 2018, of 174 screened, 84 participants (28 in each treatment group, and 31 in total with HIV) were enrolled. Two participants did not initiate study treatment (one in the delamanid group withdrew consent and one in the bedaquiline plus delamanid group) did not meet the eligibility criterion). Mean change in QTc from baseline was 12·3 ms (95% CI 7·8-16·7; bedaquiline), 8·6 ms (4·0-13·1; delamanid), and 20·7 ms (16·1-25·3) (bedaquiline plus delamanid). There were no grade 3 or 4 adverse QTc prolongation events and no deaths during study treatment. Cumulative culture conversion by week 8 was 21 (88%) of 24 (95% CI 71-97; bedaquiline), 20 (83%) of 24 (65-95; delamanid), and 19 (95%) of 20 (79-100; bedaquiline plus delamanid) and was 92% (77-99) for bedaquiline, 91% (76-99), for delamanid, and 95% (79-100) for bedaquiline plus delamanid at 24 weeks., Interpretation: Combining bedaquiline and delamanid has a modest, no more than additive, effect on the QTc interval, and initial microbiology data are encouraging. This study provides supportive evidence for use of these agents together in patients with multidrug-resistant or rifampicin-resistant tuberculosis with normal baseline QTc values., Funding: Division of AIDS, National Institutes of Health., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2021
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45. Effect of Noble Metal Addition on the Disorder Dynamics of Ni 3 Al by Means of Monte Carlo Simulation.
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Ramos-Hernandez JJ, Arrieta-Gonzalez CD, Chacon-Nava JG, Porcayo-Palafox E, Sanchez-Carrillo M, Flores-De Los Rios JP, Pedraza-Basulto GK, Diaz-Mendez SE, and Porcayo-Calderon J
- Abstract
In this work, the effect of the addition of noble metals on the order-order disorder process of the L12 structure corresponding to the intermetallic Ni
3 Al is analyzed. Stoichiometric, nonstoichiometric, and quasi-binary compositions doped with noble metals such as Ag, Au, Pd, and Pt (1 at%) were analyzed. It was observed that depending on the composition, there is a modification in the activation energies calculated from the two time constants that characterize the disorder process. The statistic of atomic jumps was typified based on the configuration of the window to be crossed and, with this, it was identified that the origin of the negative activation energy of the long disorder process is due to an increase in the corresponding energy of the AlAl-Ni jump through unnatural windows.- Published
- 2020
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46. Surveillance of adverse events in the treatment of drug-resistant tuberculosis: first global report.
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Borisov S, Danila E, Maryandyshev A, Dalcolmo M, Miliauskas S, Kuksa L, Manga S, Skrahina A, Diktanas S, Codecasa LR, Aleksa A, Bruchfeld J, Koleva A, Piubello A, Udwadia ZF, Akkerman OW, Belilovski E, Bernal E, Boeree MJ, Cadiñanos Loidi J, Cai Q, Cebrian Gallardo JJ, Dara M, Davidavičienė E, Forsman LD, De Los Rios J, Denholm J, Drakšienė J, Duarte R, Elamin SE, Escobar Salinas N, Ferrarese M, Filippov A, Garcia A, García-García JM, Gaudiesiute I, Gavazova B, Gayoso R, Gomez Rosso R, Gruslys V, Gualano G, Hoefsloot W, Jonsson J, Khimova E, Kunst H, Laniado-Laborín R, Li Y, Magis-Escurra C, Manfrin V, Marchese V, Martínez Robles E, Matteelli A, Mazza-Stalder J, Moschos C, Muñoz-Torrico M, Mustafa Hamdan H, Nakčerienė B, Nicod L, Nieto Marcos M, Palmero DJ, Palmieri F, Papavasileiou A, Payen MC, Pontarelli A, Quirós S, Rendon A, Saderi L, Šmite A, Solovic I, Souleymane MB, Tadolini M, van den Boom M, Vescovo M, Viggiani P, Yedilbayev A, Zablockis R, Zhurkin D, Zignol M, Visca D, Spanevello A, Caminero JA, Alffenaar JW, Tiberi S, Centis R, D'Ambrosio L, Pontali E, Sotgiu G, and Migliori GB
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- Adult, Aged, Female, Humans, Male, Middle Aged, Pharmacovigilance, Prospective Studies, Antitubercular Agents adverse effects, Drug-Related Side Effects and Adverse Reactions diagnosis, Drug-Related Side Effects and Adverse Reactions epidemiology, Tuberculosis, Multidrug-Resistant drug therapy
- Abstract
The World Health Organization (WHO) recommends that countries implement pharmacovigilance and collect information on active drug safety monitoring (aDSM) and management of adverse events.The aim of this prospective study was to evaluate the frequency and severity of adverse events to anti-tuberculosis (TB) drugs in a cohort of consecutive TB patients treated with new ( i.e. bedaquiline, delamanid) and repurposed ( i.e. clofazimine, linezolid) drugs, based on the WHO aDSM project. Adverse events were collected prospectively after attribution to a specific drug together with demographic, bacteriological, radiological and clinical information at diagnosis and during therapy. This interim analysis included patients who completed or were still on treatment at time of data collection.Globally, 45 centres from 26 countries/regions reported 658 patients (68.7% male, 4.4% HIV co-infected) treated as follows: 87.7% with bedaquiline, 18.4% with delamanid (6.1% with both), 81.5% with linezolid and 32.4% with clofazimine. Overall, 504 adverse event episodes were reported: 447 (88.7%) were classified as minor (grade 1-2) and 57 (11.3%) as serious (grade 3-5). The majority of the 57 serious adverse events reported by 55 patients (51 out of 57, 89.5%) ultimately resolved. Among patients reporting serious adverse events, some drugs held responsible were discontinued: bedaquiline in 0.35% (two out of 577), delamanid in 0.8% (one out of 121), linezolid in 1.9% (10 out of 536) and clofazimine in 1.4% (three out of 213) of patients. Serious adverse events were reported in 6.9% (nine out of 131) of patients treated with amikacin, 0.4% (one out of 221) with ethionamide/prothionamide, 2.8% (15 out of 536) with linezolid and 1.8% (eight out of 498) with cycloserine/terizidone.The aDSM study provided valuable information, but implementation needs scaling-up to support patient-centred care., Competing Interests: Conflict of interest: S. Borisov has nothing to disclose. Conflict of interest: E. Danila has nothing to disclose. Conflict of interest: A. Maryandyshev has nothing to disclose. Conflict of interest: M. Dalcolmo has nothing to disclose. Conflict of interest: S. Miliauskas has nothing to disclose. Conflict of interest: L. Kuksa reports personal fees for trial participation from Otsuka and Tibotec, personal fees for lectures from Johnson and Johnson Services Inc., outside the submitted work. Conflict of interest: S. Manga has nothing to disclose. Conflict of interest: A. Skrahina has nothing to disclose. Conflict of interest: S. Diktanas reports personal fees for trial participation from Otsuka, grants for meeting attendance from Janssen (Sirturo), outside the submitted work. Conflict of interest: L.R. Codecasa has nothing to disclose. Conflict of interest: A. Aleksa has nothing to disclose. Conflict of interest: J. Bruchfeld has nothing to disclose. Conflict of interest: A. Koleva has nothing to disclose. Conflict of interest: A. Piubello has nothing to disclose. Conflict of interest: Z.F. Udwadia has nothing to disclose. Conflict of interest: O.W. Akkerman has nothing to disclose. Conflict of interest: E. Belilovski has nothing to disclose. Conflict of interest: E. Bernal has nothing to disclose. Conflict of interest: M.J. Boeree has nothing to disclose. Conflict of interest: J. Cadiñanos Loidi has nothing to disclose. Conflict of interest: Q. Cai has nothing to disclose. Conflict of interest: J.J. Cebrian Gallardo has nothing to disclose. Conflict of interest: M. Dara has nothing to disclose. Conflict of interest: E. Davidavičienė has nothing to disclose. Conflict of interest: L. Davies Forsman has nothing to disclose. Conflict of interest: J. De Los Rios has nothing to disclose. Conflict of interest: J. Denholm has nothing to disclose. Conflict of interest: J. Drakšienė has nothing to disclose. Conflict of interest: R. Duarte has nothing to disclose. Conflict of interest: S.E. Elamin has nothing to disclose. Conflict of interest: N. Escobar Salinas has nothing to disclose. Conflict of interest: M. Ferrarese has nothing to disclose. Conflict of interest: A. Filippov has nothing to disclose. Conflict of interest: A. Garcia has nothing to disclose. Conflict of interest: J.M. García-García has nothing to disclose. Conflict of interest: I. Gaudiesiute has nothing to disclose. Conflict of interest: B. Gavazova has nothing to disclose. Conflict of interest: R. Gayoso has nothing to disclose. Conflict of interest: R. Gomez Rosso has nothing to disclose. Conflict of interest: V. Gruslys has nothing to disclose. Conflict of interest: G. Gualano has nothing to disclose. Conflict of interest: W. Hoefsloot has nothing to disclose. Conflict of interest: J. Jonsson has nothing to disclose. Conflict of interest: E. Khimova has nothing to disclose. Conflict of interest: H. Kunst has nothing to disclose. Conflict of interest: R. Laniado-Laborín has nothing to disclose. Conflict of interest: Y. Li has nothing to disclose. Conflict of interest: C. Magis-Escurra has nothing to disclose. Conflict of interest: V. Manfrin has nothing to disclose. Conflict of interest: V. Marchese has nothing to disclose. Conflict of interest: E. Martínez Robles has nothing to disclose. Conflict of interest: A. Matteelli has nothing to disclose. Conflict of interest: J. Mazza-Stalder has nothing to disclose. Conflict of interest: C. Moschos has nothing to disclose. Conflict of interest: M. Muñoz-Torrico has nothing to disclose. Conflict of interest: H. Mustafa Hamdan has nothing to disclose. Conflict of interest: B. Nakčerienė has nothing to disclose. Conflict of interest: L. Nicod has nothing to disclose. Conflict of interest: M. Nieto Marcos has nothing to disclose. Conflict of interest: D.J. Palmero has nothing to disclose. Conflict of interest: F. Palmieri has nothing to disclose. Conflict of interest: A. Papavasileiou has nothing to disclose. Conflict of interest: M-C. Payen has nothing to disclose. Conflict of interest: A. Pontarelli has nothing to disclose. Conflict of interest: S. Quirós has nothing to disclose. Conflict of interest: A. Rendon has nothing to disclose. Conflict of interest: L. Saderi has nothing to disclose. Conflict of interest: A. Šmite has nothing to disclose. Conflict of interest: I. Solovic has nothing to disclose. Conflict of interest: M.B. Souleymane has nothing to disclose. Conflict of interest: M. Tadolini has nothing to disclose. Conflict of interest: M. van den Boom has nothing to disclose. Conflict of interest: M. Vescovo has nothing to disclose. Conflict of interest: P. Viggiani has nothing to disclose. Conflict of interest: A. Yedilbayev has nothing to disclose. Conflict of interest: R. Zablockis has nothing to disclose. Conflict of interest: D. Zhurkin has nothing to disclose. Conflict of interest: M. Zignol has nothing to disclose. Conflict of interest: D. Visca has nothing to disclose. Conflict of interest: A. Spanevello has nothing to disclose. Conflict of interest: J.A. Caminero has nothing to disclose. Conflict of interest: J-W. Alffenaar has nothing to disclose. Conflict of interest: S. Tiberi has nothing to disclose. Conflict of interest: R. Centis has nothing to disclose. Conflict of interest: L. D'Ambrosio has nothing to disclose. Conflict of interest: E. Pontali has nothing to disclose. Conflict of interest: G. Sotgiu has nothing to disclose. Conflict of interest: G.B. Migliori has nothing to disclose., (Copyright ©ERS 2019.)
- Published
- 2019
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47. Constrained acetabular liners in hip revision surgery. A low-cost solution for senile patients.
- Author
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Hernandez-Vaquero D, Llorens De Los Rios J, Perez-Coto I, Iglesias-Fernandez S, Fernandez-Lombardia J, and Cuervo-Olay MDC
- Subjects
- Aged, Aged, 80 and over, Arthroplasty, Replacement, Hip economics, Bone Cements therapeutic use, Cost-Benefit Analysis, Female, Humans, Male, Reoperation economics, Retrospective Studies, Acetabulum surgery, Arthroplasty, Replacement, Hip instrumentation, Hip Dislocation surgery, Hip Prosthesis economics, Periprosthetic Fractures surgery, Polyethylene, Prosthesis Failure, Prosthesis-Related Infections surgery, Reoperation instrumentation
- Abstract
The objective of this study was to analyze the results of a cemented polyethylene model that captures the hip prosthetic head. In a retrospective study we reviewed 36 cemented constrained acetabular liners implanted in patients older than 75 years (mean 83, SD : 4.4), of which 30 patients were aged 80-90 years and 26 were women. The average period of follow-up of our patients was 25.4 months (12-39 months, SD : 7.3). In 26 patients this model was implanted due to recurrent dislocation or instability, in 8 other cases this model was implanted during revision surgery for periprosthetic fractures, aseptic loosening of the -acetabular component, wear of the polyethylene or replacement of the implant because of infection. There was a single case of recurrent dislocation (2.8%). Cemented acetabular constrained liners are a good option in revision surgery in senile patients in which the femoral stem is firmly fixed to the bone.
- Published
- 2016
48. Computer-assisted surgery improves rotational positioning of the femoral component but not the tibial component in total knee arthroplasty.
- Author
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Hernandez-Vaquero D, Noriega-Fernandez A, Fernandez-Carreira JM, Fernandez-Simon JM, and Llorens de los Rios J
- Subjects
- Aged, Female, Femur physiopathology, Femur surgery, Humans, Knee Joint diagnostic imaging, Knee Prosthesis, Male, Middle Aged, Posture, Prospective Studies, Rotation, Surgery, Computer-Assisted, Tibia diagnostic imaging, Tibia surgery, Tomography, X-Ray Computed, Arthroplasty, Replacement, Knee methods, Joint Diseases surgery, Knee Joint surgery
- Abstract
Purpose: Computer-assisted surgery (CAS) may facilitate better positioning of total knee arthroplasty (TKA) along the coronal and lateral axes; however, there are doubts as to its usefulness in the rotational plane., Methods: This is a prospective study of 95 TKAs comparing two groups: the CAS group and the standard equipment group. The series comprises 95 cases. A radiography of the lower limb and computer tomographies (CTs) of the femoral condylar region, the proximal end of the tibia and the ankle were performed to measure rotational angulation. A month after TKA surgery, the radiography and the CTs were repeated to analyze the position of the prosthetic components in the rotational plane., Results: In the coronal axis, both CAS and mechanical technique improved femoro-tibial alignment, but when there are preexisting deformities ≥4°, CAS obtains better results. A strong correlation (R = 0.94, p = 0.001) was observed between the mean rotational axis measured with CT in the tibial plateau and that measured from the axis of the ankle. The mean initial femoral rotation of the complete series was 6.7° and 2.7° at 1-month follow-up (p < 0.001). In the standard instrumentation group, the femoral rotation went from 6.8° to 2.3°, whereas in the CAS group the femoral rotation went from 6.5° to 3.1° (p = 0.039), which is very close to the ideal 3° angle of external rotation. Tibial rotation changed by 5.28° for the entire patient population, but no differences were found when comparing CAS and standard instrumentation., Conclusion: CAS improves frontal alignment in TKA, especially in the presence of preoperative deformities. In the femoral component, navigation most closely replicated the ideal 3° external rotation of the femoral component, but tibial rotation did not differ when comparing CAS to standard instrumentation., Level of Evidence: II.
- Published
- 2014
- Full Text
- View/download PDF
49. [High-resolution microdialysis. methodological issues and application to the study of inflammatory brain response].
- Author
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De Los Rios JA, Sahuquillo J, Merino MA, Poca MA, and Expósito L
- Subjects
- Animals, Craniocerebral Trauma complications, Craniocerebral Trauma physiopathology, Cytokines chemistry, Cytokines physiology, Diffusion, Encephalitis etiology, Humans, Inflammation Mediators analysis, Membranes, Artificial, Metalloproteases chemistry, Metalloproteases physiology, Microdialysis instrumentation, Models, Molecular, Perfusion, Protein Conformation, Ultrafiltration, Brain Chemistry, Craniocerebral Trauma metabolism, Encephalitis metabolism, Microdialysis methods, Nerve Tissue Proteins analysis
- Abstract
Cerebral microdialysis is a tool that provides very relevant information in the metabolic monitoring of brain injured patients. It is a particularly effective technique for the detection and analysis of small molecules, given that the pores of the dialysis membrane act as a barrier to restrict the transport of larger species, such as proteins and other macromolecules. The recent availability of microdialysis catheters with membrane pores of larger size, termed "high resolution" catheters, would widen the spectrum of molecules detectable in the dialisate. However, there are technical complications related to the use of these catheters for such purposes, and therefore, this potential capacity for the recovery of proteins needs to be validated, in order to begin its application as a tool in studies of proteomics associated with brain injuries. The following review depicts the basic principles of microdialysis, and describes some of the issues involved in the recovery of molecules in the dialisate, including the physical properties of the dialysis membrane and of the molecules of interest.
- Published
- 2009
50. Percutaneous implantation of cerebral microdialysis catheters by twist-drill craniostomy in neurocritical patients: description of the technique and results of a feasibility study in 97 patients.
- Author
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Poca MA, Sahuquillo J, Vilalta A, de los Rios J, Robles A, and Exposito L
- Subjects
- Adolescent, Adult, Aged, Catheterization adverse effects, Craniotomy adverse effects, Feasibility Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Brain Injuries surgery, Catheterization methods, Craniotomy methods, Critical Care, Infarction, Middle Cerebral Artery surgery, Microdialysis instrumentation
- Abstract
Cerebral microdialysis is increasingly used to monitor several types of neurocritical patients. This study presents the technique used in our unit for percutaneous implantation of cerebral microdialysis catheters using a small twist-drill craniostomy that can be performed in the intensive care unit (ICU). We also present the results of this technique in 89 head-injured patients and in eight patients with a malignant middle cerebral artery (MCA) infarction. One hundred and twenty-two cerebral microdialysis catheters were implanted in the 97 patients included in this study. One cerebral microdialysis catheter was implanted in the less damaged hemisphere of 67 head-injured patients with a diffuse brain injury. An additional microdialysis catheter was inserted in the pericontusional parenchyma of 22 patients with brain contusions. In five of the eight patients with a malignant MCA infarction, only one microdialysis probe was inserted in the penumbral zone. In the remaining three patients, two cerebral microdialysis catheters were implanted in the same hemisphere (one in the ischemic core and the other in the penumbra). Technical problems were detected in 18 (15%) of the 122 microdialysis catheters implanted and were more frequent during the initial period of using microdialysis in our unit. In four patients (3% of implanted catheters), follow-up computed tomography (CT) scans showed a small intracerebral blood collection (always
- Published
- 2006
- Full Text
- View/download PDF
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