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109 results on '"Centro de Edafologia y Biologia, Aplicada del Segura"'

1. A systematic review and meta-analysis of the effects of flavanol-containing tea, Cocoa and apple products on body composition and blood lipids: Exploring the factors responsible for variability in their efficacy

Author

González-Sarrías, Antonio, Combet, Emilie, Pinto, Paula, Mena, Pedro, Dall’Asta, Margherita, Garcia-Aloy, Mar, Rodríguez-Mateos, Ana, Gibney, Eileen R., Dumont, Julie, Massaro, Marika, Sánchez-Meca, Julio, Morand, Christine, García-Conesa, María-Teresa, Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, College of Medical Veterinary & Life Sciences, University of Glasgow, Department of Food Technology, Biotechnology and Nutrition, Insituto Politécnico de Santarém, Human Nutrition Unit, Department of Food & Drug, University of Parma, Department of Nutrition, Food Sciences and Gastronomy, University of Barcelona, CIBERFES, Instituto de Salud Carlos III (ISC), Division of Diabetes and Nutritional Sciences, King‘s College London, Institute of Food and Health, University College Dublin [Dublin] (UCD), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement (Inserm U1167 - RID-AGE - Institut Pasteur), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Lille (CHU de Lille), Istituto di Fisiologia Clinica (IFC), CNR, Department of Basic Psychology and Methodology, Universidad de Murcia, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centro de Edafologia y Biologia Aplicada del Segura, COST Action FA1403 'POSITIVe', Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of Parma = Università degli studi di Parma [Parme, Italie], Instituto de Salud Carlos III [Madrid] (ISC), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Università degli studi di Parma = University of Parma (UNIPR), and ProdInra, Archive Ouverte

Subjects
cardiometabolic disorders, tea, blood lipids, food and beverages, apple, lcsh:TX341-641, body mass index, Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE, Review, waist circumference, essai randomisé contrôlé, interindividual variability, meta-analysis, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, flavanol, cardiovascular disease, cocoa, maladie cardiovasculaire, méta-analyse, flavanols, lcsh:Nutrition. Foods and food supply, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

Several randomized controlled trials (RCTs) and meta-analyses support the benefits of flavanols on cardiometabolic health, but the factors affecting variability in the responses to these compounds have not been properly assessed. The objectives of this meta-analysis were to systematically collect the RCTs-based-evidence of the effects of flavanol-containing tea, cocoa and apple products on selected biomarkers of cardiometabolic risk and to explore the influence of various factors on the variability in the responses to the consumption of these products. A total of 120 RCTs were selected. Despite a high heterogeneity, the intake of the flavanol-containing products was associated using a random model with changes (reported as standardized difference in means (SDM)) in body mass index (−0.15, p < 0.001), waist circumference (−0.29, p < 0.001), total-cholesterol (−0.21, p < 0.001), LDL-cholesterol (−0.23, p < 0.001), and triacylglycerides (−0.11, p = 0.027), and with an increase of HDL-cholesterol (0.15, p = 0.005). Through subgroup analyses, we showed the influence of baseline-BMI, sex, source/form of administration, medication and country of investigation on some of the outcome measures and suggest that flavanols may be more effective in specific subgroups such as those with a BMI ≥ 25.0 kg/m2, non-medicated individuals or by specifically using tea products. This meta-analysis provides the first robust evidence of the effects induced by the consumption of flavanol-containing tea, cocoa and apple products on weight and lipid biomarkers and shows the influence of various factors that can affect their bioefficacy in humans. Of note, some of these effects are quantitatively comparable to those produced by drugs, life-style changes or other natural products. Further, RCTs in well-characterized populations are required to fully comprehend the factors affecting inter-individual responses to flavanol and thereby improve flavanols efficacy in the prevention of cardiometabolic disorders info:eu-repo/semantics/publishedVersion

Published
2017
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2. Beyond barriers: the fluid roles young people adopt in water conflict and cooperation

Author

Vojno, N, ter Horst, R, Hussein, H, Nolden, T, Badawy, A, Goubert, A, Sharipova, B, Pedrero, F, Peters, S, Damkjaer, S, IHE Delft Institute for Water Education, Ministry of Foreign Affairs (The Netherlands), University of Oxford, Tokyo Woman's Christian University (TWCU), Wageningen University and Research [Wageningen] (WUR), University of Oxford [Oxford], Institute for Water Education (IHE Delft ), Boston University [Boston] (BU), Centre méditerranéen de sociologie, de science politique et d’histoire (Mesopolhis), Sciences Po Aix - Institut d'études politiques d'Aix-en-Provence (IEP Aix-en-Provence)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of Applied Sciences [Offenburg], and University College of London [London] (UCL)

Subjects
Water cooperation, foresight, Foresight, WASS, Management, Monitoring, Policy and Law, Water Resources Management, young people, [SHS]Humanities and Social Sciences, Peace-building, Water diplomacy, water diplomacy, Young people, peace-building, Water Science and Technology
Abstract

Most people on this planet are under the age of 35. They have been raising their voices in discussions on climate change in recent years, while this is well documented, their roles in water cooperation are not. Drawing on examples from desk research, an online survey, and action research alongside young water leaders, this article seeks to map out various ways young people engage in water conflict and cooperation. This paper contributes to literature on water leadership by recognizing the fluid and adaptive roles of young people in water conflict and cooperation., This research and publication was financed through the IHE Delft Water and Development Partnership Programme (DUPC) funded by the DGIS, the development cooperation agency of the Dutch Ministry of Foreign Affairs. This publication was also made possible by the Oxford Martin School, University of Oxford

Published
2022
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3. Regenerative agriculture—agroecology without politics?

Author

Pablo Tittonell, Veronica El Mujtar, Georges Felix, Yodit Kebede, Luciana Laborda, Raquel Luján Soto, Joris de Vente, Agroécologie et Intensification Durables des cultures annuelles (UPR AIDA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Département Performances des systèmes de production et de transformation tropicaux (Cirad-PERSYST), University of Groningen [Groningen], Instituto de Investigaciones Forestales y Agropecuarias Bariloche (IFAB), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Instituto Nacional de Tecnología Agropecuaria (INTA), Centre for Agroecology, Water and Resilience (CAWR), Coventry University, Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes (UMR Eco&Sols), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidad de Córdoba = University of Córdoba [Córdoba], and Tittonell group

Subjects
P36 - Érosion, conservation et récupération des sols, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, Global and Planetary Change, Ecology, F08 - Systèmes et modes de culture, agroécologie, Conservation des sols, Horticulture, Management, Monitoring, Policy and Law, sustainability, agroecological transition, climate change, Récupération des sols, soil restoration, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, resilience, Agronomy and Crop Science, Food Science
Abstract

International audience

Published
2022
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4. Evaluation of Phoenix dactylifera Edible Parts and Byproducts as Sources of Phytoprostanes and Phytofurans

Author

Sonia Medina, Ibrahim M. Abu-Reidah, Raúl Domínguez-Perles, Jean-Marie Galano, Angel Gil-Izquierdo, Thierry Durand, Valérie Bultel-Poncé, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
2. Zero hunger, 0106 biological sciences, Range (biology), [SDV]Life Sciences [q-bio], Dietary intake, 010401 analytical chemistry, General Chemistry, phytoprostanes, 15. Life on land, Biology, 01 natural sciences, 0104 chemical sciences, phytofurans, targeted metabolomics, Phoenix dactylifera, byproducts, Food science, General Agricultural and Biological Sciences, UHPLC−ESI-QqQ-MS/MS, date palm, 010606 plant biology & botany, Targeted metabolomics
Abstract

International audience; Even though traditionally date-fruit has been featured by a marginal use, mainly restricted to its dietary intake, in recent years, it has raised the range of applications for this agro-food production. These new uses have entailed an enlarged production of date fruits and, simultaneously, of date palm byproducts. Encouraged by the traditional medicinal uses of dates, according to their phytochemical composition, the present work was focused on the evaluation of a new family of secondary metabolites, the plant oxylipins phytoprostanes (PhytoPs) and phytofurans (PhytoFs), in six separate matrixes of the date palm edible parts and byproducts, applying an UHPLC–ESI-QqQ-MS/MS-based methodology. The evaluation for the first time of date palm edible parts and byproducts as a dietary source of PhytoPs and PhytoFs provides evidence on the value of six different parts (pulp, skin, pits, leaves, clusters, and pollen) regarding their content in these plant oxylipins evidenced by the presence of the PhytoPs, 9-F1t-PhytoP (201.3–7223.1 ng/100 g dw) and 9-epi-9-F1t-PhytoP (209.7–7297.4 ng/100 g dw), and the PhytoFs ent-16(RS)-9-epi-ST-Δ14-10-PhytoF (4.6–191.0 ng/100g dw), and ent-16(RS)-13-epi-ST-Δ14-9-PhytoF as the most abundant compounds. Regarding the diverse matrixes assessed, pollen, clusters, and leaves for PhytoPs and skins and pollen for PhytoFs were identified as the most interesting sources of these compounds. In this concern, the information obtained upon the detailed characterization performed in the present work will allow unravelling the biological interest of PhytoPs and PhytoFs and the extent to which these compounds could exert valuable biological activities upon in vitro (mechanistic) and in vivo studies, allocating the effort-focus on the chemical species of PhytoPs and PhytoFs responsible for such traits.

Published
2020
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5. Effects of Deficit Irrigation, Rootstock, and Roasting on the Contents of Fatty Acids, Phytoprostanes, and Phytofurans in Pistachio Kernels

Author

I. Griñán, Sonia Medina, Raúl Domínguez-Perles, Angel Gil-Izquierdo, Ángel A. Carbonell-Barrachina, Arturo Torrecillas, Federico Ferreres, Marina Cano-Lamadrid, Thierry Durand, Ana Centeno, Alexandre Guy, David Pérez-López, Jean-Marie Galano, Jacinta Collado-González, Universidad Miguel Hernández [Elche] (UMH), Universidad Politécnica de Madrid (UPM), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Universidad Católica San Antonio de Murcia (UCAM)

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, 0106 biological sciences, Agricultural Irrigation, Linoleic acid, GC−MS, Deficit irrigation, MESH: Plant Extracts, MESH: Plant Roots, Biology, Plant Roots, 01 natural sciences, water stress, chemistry.chemical_compound, phytofurans, MESH: Water, Cooking, Cultivar, Furans, MESH: Pistacia, Roasting, Pistacia vera, 2. Zero hunger, UHPLC−MS/MS, Pistacia, Plant Extracts, business.industry, MESH: Furans, Fatty Acids, 010401 analytical chemistry, Water, MESH: Cooking, General Chemistry, phytoprostanes, biology.organism_classification, MESH: Fatty Acids, 0104 chemical sciences, Horticulture, Oleic acid, MESH: Seeds, chemistry, Agriculture, Seeds, General Agricultural and Biological Sciences, business, Rootstock, MESH: Agricultural Irrigation, 010606 plant biology & botany
Abstract

International audience; Pistachio (Pistacia vera L.) is a drought-tolerant species grown under the semiarid conditions of the Mediterranean basin. For this reason, it is essential to make an exhaustive quantification of yield and quality benefits of the kernels because the regulated deficit irrigation will allow significant water savings with a minimum impact on yield while improving kernel quality. The goal of this scientific work was to study the influence of the rootstock, water deficit during pit hardening, and kernel roasting on pistachio (P. vera, cv. Kerman) fruit yield, fruit size, and kernel content of fatty acids phytoprostanes (PhytoPs) and phytofurans (PhytoFs) for the first time. Water stress during pit hardening did not affect the pistachio yield. The kernel cultivar showed a lower oleic acid and a higher linoleic acid contents than other cultivars. Kernels from plants grafted on the studied rootstocks showed very interesting characteristics. P. integerrima led to the highest percentage of monounsaturated fatty acids. Regarding the plant oxylipins, P. terebinthus led to the highest contents of PhytoPs and PhytoFs (1260 ng/100 g and 16.2 ng/100 g, respectively). In addition, nuts from trees cultivated under intermediate water deficit during pit hardening showed increased contents of the 9-series F1-phytoprostanes and ent-16(RS)-9-epi-ST-Δ14-10-phytofuran. However, roasting of pistachios led to PhytoP degradation. Therefore, plant cultivar, deficit irrigation, rootstock, and roasting must be considered to enhance biosynthesis of these secondary metabolites. New tools using agricultural strategies to produce hydroSOS pistachios have been opened thanks to the biological properties of these prostaglandin-like compounds linking agriculture, nutrition, and food science technology for further research initiatives.

Published
2020
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6. Phytoprostanes and Phytofurans—Oxidative Stress and Bioactive Compounds—in Almonds are Affected by Deficit Irrigation in Almond Trees

Author

Sonia Medina, Jean-Marie Galano, Thierry Durand, Raúl Domínguez-Perles, Angel Gil-Izquierdo, Mireia Corell, Leontina Lipan, Jacinta Collado-González, Ángel A. Carbonell-Barrachina, Valérie Bultel-Poncé, Universidad Miguel Hernández [Elche] (UMH), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of Sevilla, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, Agricultural Irrigation, [SDV]Life Sciences [q-bio], α-linolenic acid, Deficit irrigation, Biology, Health benefits, medicine.disease_cause, 01 natural sciences, Regulated deficit irrigation, medicine, Plant defense against herbivory, Food science, Furans, 2. Zero hunger, chemistry.chemical_classification, HydroSOStainable products, 010401 analytical chemistry, Water, food and beverages, General Chemistry, Prunus dulcis, 0104 chemical sciences, Oxidative Stress, Sustained deficit irrigation, Stress biomarkers, chemistry, Seeds, Fatty Acids, Unsaturated, General Agricultural and Biological Sciences, Biomarkers, Oxidative stress, 010606 plant biology & botany, Polyunsaturated fatty acid
Abstract

International audience; Almonds have gained consumers’ attention due to their health benefits (they are rich in bioactive compounds) and sensory properties. Nevertheless, information about phytoprostanes (PhytoPs) and phytofurans (PhytoFs) (new plant markers of oxidative stress and compounds with biological properties for human health) in almonds under deficit irrigation is scarce or does not exist. These compounds are plant oxylipins synthesized by the oxidation of α-linolenic acid (ALA). Besides, they are biomarkers of plant oxidative degradation and biologically active molecules involved in several plant defense mechanisms. hydroSOStainable or hydroSOS mean plant foods made from from plants under controlled water stress. Almonds are a good source of polyunsaturated fatty (PUFAs) acids, including a high content of ALA. This paper aimed to describe the influence of diverse irrigation treatments on in vitro anti-oxidant activity (AAc) and total phenolic content (TPC), as well as on the level of ALA, PhytoP, and PhytoF in “Vairo” almonds. The AAc and TPC were not affected by the irrigation strategy, while the in vivo oxidative stress makers, PhytoPs and PhytoFs, exhibited significant differences in response to water shortage. The total PhytoP and PhytoF contents ranged from 4551 to 8151 ng/100 g dry weight (dw) and from 33 to 56 ng/100 g dw, respectively. The PhytoP and PhytoF profiles identified in almonds showed significant differences among treatments. Individual PhytoPs and PhytoFs were present above the limit of detection only in almonds obtained from trees maintained under deficit irrigation (DI) conditions (regulated deficit irrigation, RDI, and sustained deficit irrigation, SDI) but not in control almonds obtained from fully irrigated trees. Therefore, these results confirm PhytoPs and PhytoFs as valuable biomarkers to detect whether an almond-based product is hydroSOStainable. As a final conclusion, it can be stated that almond quality and functionality can be improved and water irrigation consumption can be reduced if controlled DI strategies are applied in almond orchards.

Published
2020
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7. Transdisciplinary innovation in irrigated smallholder agriculture in africa

Author

Serge Marlet, Salia Hanafi, Philippe Ker Rault, Tarek Ajmi, Bandiougou Diawara, Yacouba M. Coulibaly, Jochen Froebrich, Elijah Phiri, Aleksandra Dolinska, Nathaniel Mason, Cai Xueliang, Benson H. Chishala, Christy van Beek, Beatrice Mosello, Insaf Mekki, Joris de Vente, Mohammed Dicko, Constansia D Musvoto, Sebastião Famba, Willem de Clercq, Eva Ludi, Nebo Jovanovic, Naomi Oates, Maite Sánchez Reparaz, Andrei Rozanov, Solomon Habtu, Sami Bouarfa, Chizumba Shepande, Angel De Miguel Garcia, Bréhima Tangara, Teklu Erkossa, Abdelaziz Zairi, Kees van't Klooster, Maria Roble, Sékou Bah, Hanneke Heesmans, Dominique Rollin, Haithem Bahri, Julia Harper, Jean Emmanuel Rougier, Ludivine Pradeleix, Rami Albasha, Bruno Cheviron, Marlene de Witt, Jean Claude Mailhol, Gonzalo G. Barberá, Degol Fissahaye, Alice M. Mweetwa, Erik Querner, Raphaëlle Ducrot, Jean-Yves Jamin, Gestion de l'Eau, Acteurs, Usages (UMR G-EAU), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-AgroParisTech-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut de Recherche pour le Développement (IRD)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-AgroParisTech-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Wageningen Environmental Research (Alterra), Overseas Development Institute, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-AgroParisTech-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Council for Scientific and Industrial Research [Pretoria] (CSIR), Columbia Mailman School of Public Health, Institut National de Recherche en Génie Rural Eaux et Forêts (INRGREF), Ecole Nationale du Génie Rural, des Eaux et des Forêts (ENGREF)-Institution de la Recherche et de l'Enseignement Supérieur Agricoles [Tunis] (IRESA), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of Zambia [Lusaka] (UNZA), Stellenbosch University, Énergie Matériaux Télécommunications - INRS (EMT-INRS), Institut National de la Recherche Scientifique [Québec] (INRS)-Université du Québec à Montréal = University of Québec in Montréal (UQAM), INSTITUT D'ECONOMIE RURALE BAMAKO MLI, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Lisode, Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), German International Cooperation, NUNIVERSIDADE EDUARDO MONDLANE MAPUTO MOZ, Mekelle University, Adelphi, University of Sheffield [Sheffield], Institute of Environmental Assessment and Water Research (IDAEA), Technical University of Cartagena (UPTC), IER Niono, Mali, Institut d'Economie Rurale du Mali - CRRA Niono (IER - Niono), IER-IER, Cebas-Csic, International Water Management Institute [CGIAR, Sri Lanka] (IWMI), Consultative Group on International Agricultural Research [CGIAR] (CGIAR), Institute for Water Education (IHE Delft ), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-AgroParisTech-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Columbia University [New York], Universidad Politécnica de Cartagena / Technical University of Cartagena (UPCT), National funding organizations, especially in Ethiopia, Mozambique, South Africa, Mali and Tunisia, to co-finance staff, infrastructure and activities., European Project: 265471,EC:FP7:KBBE,FP7-AFRICA-2010,EAU4FOOD(2011), and European Project: 688320,H2020,H2020-WATER-2015-two-stage,MADFORWATER(2016)

Subjects
F08 - Systèmes et modes de culture, 0208 environmental biotechnology, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, Water en Voedsel, 02 engineering and technology, Commission, irrigation, recherche participative, Research process, Engineering, smallholder farming, F06 - Irrigation, Environmental planning, 2. Zero hunger, Food security, E90 - Structure agraire, [SDE.IE]Environmental Sciences/Environmental Engineering, transdisciplinary approach, Agriculture, 04 agricultural and veterinary sciences, PE&RC, Water resource management, Drainage, agriculture familiale, Exploitation agricole familiale, Soil Science, Time frame, transdisciplinary approach, participatory innovation, smallholder farming, irrigation, approche transdisciplinaire, innovation participative, petites exploitations agricoles, irrigation, Recherche sur les systèmes agraires, 12. Responsible consumption, Farm level, Innovation, WIMEK, Water and Food, business.industry, 020801 environmental engineering, smallholder farming, irrigation, Climate Resilience, participatory innovation, Klimaatbestendigheid, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, business, Agronomy and Crop Science
Abstract

SI; International audience; Boosting the productivity of smallholder farming systems continues to be a major need in Africa. Challenges relating to how to improve irrigation are multi‐factor and multisectoral, and they involve a broad range of actors who must interact to reach decisions collectively. We provide a systematic reflection on findings from the research project EAU4Food, which adopted a transdisciplinary approach to irrigation for food security research in five case studies in Ethiopia, Mali, Mozambique, South Africa and Tunisia. The EAU4Food experiences emphasize that actual innovation at irrigated smallholder farm level remains limited without sufficient improvement of the enabling environment and taking note of the wider political economy environment. Most project partners felt at the end of the project that the transdisciplinary approach has indeed enriched the research process by providing different and multiple insights from actors outside the academic field. Local capacity to facilitate transdisciplinary research and engagement with practitioners was developed and could support the continuation and scaling up of the approach. Future projects may benefit from a longer time frame to allow for deeper exchange of lessons learned among different stakeholders and a dedicated effort to analyse possible improvements of the enabling environment from the beginning of the research process. © 2020 The Authors. Irrigation and Drainage published by John Wiley & Sons Ltd on behalf of International Commission for Irrigation and Drainage

Published
2020
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8. Is deficit irrigation with saline waters a viable alternative for winegrowers in semiarid areas?

Author

Alejandro Martínez-Moreno, Eva Pérez-Álvarez, Ramon López-Urrea, Diego Intrigliolo, M. Reyes González-Centeno, Pierre-Louis Teissedre, Rocío Gil-Muñoz, Universidad de Murcia, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Unité de Recherche Œnologie [Villenave d'Ornon] (OENO), Université de Bordeaux (UB)-Institut des Sciences de la Vigne et du Vin (ISVV)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Instituto Murciano de Investigación y desarrollo Agrario y Alimentario (IMIDA), European Project: CTM2016-78607-P ,AEI/FEDER, Ministerio de Ciencia, Innovación y Universidades (España), and Agencia Estatal de Investigación (España)

Subjects
Monastrell, Botany, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, food and beverages, Agriculture, phenolic compounds, Horticulture, anthocyanins, salinity, QK1-989, Vitis vinifera, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Food Science
Abstract

Two of the main challenges of Mediterranean viticulture is low water quality and the risk of increasing concentrations of mineral salts in the root zone. This work was undertaken to study the impact of saline deficit irrigation on grape and wine phenolic composition, as well as on the sensory profile of the wines. The experiment was carried out during three consecutive years (2016-2018) in a commercial vineyard of cv. Monastrell (Vitis vinifera L.) grafted onto 1103P rootstock located in D.O. Jumilla (SE Spain). Three watering regimes were carried out: i) the control (“Control”): the vines were irrigated with water of standard quality, ii) Sulfate treatment (“Sul”): the vines were irrigated with saline water (Na₂SO₄ + MgSO4), and iii) Chloride treatment (“Chl”): the vines were irrigated with saline water (NaCl). The same amount of irrigation water was applied to all the treatments. The water electrical conductivity was 1.8 dS/m for Control and 5 dS/m for the saline treatments (Sul and Chl). Both the Sul and Chl treatments reduced the berry weight in all the study years compared to Control, although this difference was statistically significant in the last year only (p ≤ 0.05). No significant differences (p > 0.05) were observed in the grape quality parameters. However, the saline treatments slightly increased grape total soluble solids (TSS) in two out of the three study years compared to Control. Regarding the phenolic composition, no significant differences (p > 0.05) among treatments were found in grapes and wines. In general, the wines from vines irrigated with saline waters received the best scores by the panel in the sensory profile analysis. The use of saline waters could be employed in the case of water scarcity, as long as the vineyard is planted on a rootstock tolerant to salinity, such as 1103P, and the vineyard soil has a texture that favours leaching., The research was funded by AEI-FEDER project AGL2017-83738-C3-3-R.

Published
2022
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9. Special Issue 'Microorganisms in Recycling and Valorization of Organic Waste for Sustainable Soil Health and Management'

Author

María Gómez-Brandón, José A. Siles, Mercedes García-Sánchez, University of California [Berkeley], University of California, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes (UMR Eco&Sols), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidade de Vigo, Xunta de Galicia (grant number ED431F 2018/05), University of California [Berkeley] (UC Berkeley), University of California (UC), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)

Subjects
2. Zero hunger, Microbiology (medical), Soil health, 0303 health sciences, Waste management, 030306 microbiology, QH301-705.5, Microorganism, Biodegradable waste, [SDV.SA.SDS]Life Sciences [q-bio]/Agricultural sciences/Soil study, Microbiology, 6. Clean water, 12. Responsible consumption, 03 medical and health sciences, n/a, Editorial, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, 13. Climate action, Virology, Environmental science, Biology (General), ComputingMilieux_MISCELLANEOUS, 030304 developmental biology
Abstract

Anthropogenic activity generates huge amounts of solid organic wastes [...]

Published
2021
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10. Nitrogen dynamics in cropping systems under Mediterranean climate: a systemic analysis

Author

Benjamín S. Gimeno, J.P.C. Eekhout, Estela Romero, Gilles Billen, Josette Garnier, Wolfgang Cramer, Maria Luz Cayuela, Margarita Ruiz Ramos, Bruna Grizzetti, Alberte Bondeau, Antonio Vallejo, Diego S. Intrigliolo, Luis Lassaletta, Miguel Quemada, Alberto Sanz-Cobena, Eduardo Aguilera, ETSI Agronómica, Alimentaria y de Biosistemas, CEIGRAM, Universidad Politécnica de Madrid, Spain, Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols (METIS), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), European Commission Joint Research Centre (JRC), Ispra (VA), Italy, ETSI Agronomos, Universidad Politécnica de Madrid (UPM), Ecotoxicology of Air Pollution, Ecotoxicology of Air Pollution (CIEMAT), ANR-11-LABX-0061,OTMed,Objectif Terre : Bassin Méditerranéen(2011), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), European Project: 603542,EC:FP7:ENV,FP7-ENV-2013-two-stage,LUC4C(2013), European Commission, Agence Nationale de la Recherche (France), Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Lassaletta, Luis (0000-0001-9428-2149), Sanz-Cobena, Alberto (0000-0003-2119-5620), Aguilera, Eduardo (0000-0003-4382-124X), Quemada, Miguel (0000-0001-5793-2835), Billen, Gilles (0000-0003-4413-4169), Bondeau, Alberte (0000-0002-8729-5061), Cayuela, María Luz (0000-0003-0929-4204), Cramer, Wolfgang (0000-0002-9205-5812), Eekhout, Joris P.C. (0000-0003-2097-696X), Garnier, Josette (0000-0001-9416-9242), Grizzetti, Bruna (0000-0001-5570-8581), Intrigliolo, Diego S. (0000-0001-5368-5478), Ramos, Margarita Ruiz (0000-0003-0212-3381), Nadal‐Romero, Estela (0000-0003-3115-7572), Vallejo, Antonio (0000-0003-0311-7450), Gimeno, Benjamín S. (0000-0002-8620-7138), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Technical University of Madrid

Subjects
Mediterranean climate, 010504 meteorology & atmospheric sciences, Adaptation and mitigation synergies, chemistry.chemical_element, 01 natural sciences, Nitrogen fertilization, Nitrogen pollution, Regional strategies, Mediterranean region, 0105 earth and related environmental sciences, General Environmental Science, 2. Zero hunger, Systemic analysis, Renewable Energy, Sustainability and the Environment, Public Health, Environmental and Occupational Health, 04 agricultural and veterinary sciences, 15. Life on land, Nitrogen, Nitrogen-water interaction, Nitrogen fertilizer, Agronomy, chemistry, 13. Climate action, Nutrient pollution, [SDE]Environmental Sciences, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Environmental science, Cropping
Abstract

Worldwide, Mediterranean cropping systems face the complex challenge of producing enough high-quality food while preserving the quantity and quality of scarce water for people and agriculture in the context of climate change. While good management of nitrogen (N) is paramount to achieving this objective, the efficient strategies developed for temperate systems are often not adapted to the specificities of Mediterranean systems. In this work, we combine original data with a thorough literature review to highlight the most relevant drivers of N dynamics in these semi-arid systems. To do so, we provide an analysis at nested scales combining a bottom-up approach from the field scale, with a top-down approach considering the agro-food system where cropping systems are inserted. We analyze the structural changes in the agro-food systems affecting total N entering the territory, the contrasting response of yields to N availability under rainfed and irrigated conditions in a precipitation gradient, the interaction between N management and climate change adaptation, the main drivers affecting the release of Nr compounds (nitrate, ammonia, nitric oxide and nitrous oxide) compared with temperate systems and finally, the behavior of N once exported to highly regulated river networks. We conclude that sustainable N management in Mediterranean cropping systems requires the specific adaptation of practices to particular local agro-environmental characteristics with special emphasis on water availability for rainfed and irrigated systems. This approach should also include a systemic analysis of N input into the territory that is driven by the configuration of the agro-food system., This work was partly supported by 7th Framework Programmes funded by the European Union through the LUC4C project (Grant Agreement 603542). A Bondeau and W Cramer acknowledge Labex OTMed (ANR-11-LABX-0061) funded by the French Government Investissements d’Avenir program of the French National Research Agency (ANR) through the A∗MIDEX project (ANR-11-IDEX-0001-02). The authors are grateful to the Spanish Ministry of Economy and Competitiveness (AgroSceNA-UP, PID2019-107972RB-I00), the Comunidad de Madrid, Spain (AGRISOST-CM S2018/BAA-4330 pro ject). L Lassaletta is supported by Spanish Ministry of Economy and Competitiveness (MINECO) and European Commission ERDF Ramón y Cajal grant (RYC-2016-20269), Programa Propio from UPM and acknowledges the Comunidad de Madrid (Spain) and structural funds 2014-2020 (ERDF and ESF). Lassaletta is extremely grateful to Rafael Lassaletta (Nano) for permanent support and care. E Aguilera is supported by a Juan de la Cierva research contract from the Spanish Ministry of Economy and Competitiveness (FJCI-2017-34077). A Sanz-Cobena grate fully acknowledges the Autonomous Community of Madrid and UPM for their economic support through the research project APOYOJOVENES NFW8ZQ-42-XE8B5K.

Published
2021
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11. Phytoprostanes and phytofurans modulate COX-2-linked inflammation markers in LPS-stimulated THP-1 monocytes by lipidomics workflow

Author

Raúl Domínguez-Perles, Valérie Bultel-Poncé, Jean-Marie Galano, Federico Fanti, Juana Inés Gallego-Gómez, Angel Gil-Izquierdo, Agustín Javier Simonelli-Muñoz, Sonia Medina, María Campillo, Francisco A. Tomás-Barberán, Thierry Durand, Universidad Católica San Antonio de Murcia (UCAM), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universita degli studi di Teramo - University of Teramo [Italie] (UNITE), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Taif University, Partenaires INRAE, Fundación Séneca, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Consejo Superior de Investigaciones Científicas (España), CSIC - Centro de Edafología y Biología Aplicada del Segura (CEBAS), Centre National de la Recherche Scientifique (France), and Université de Montpellier

Subjects
0301 basic medicine, Lipopolysaccharides, MESH: Inflammation, Lipopolysaccharide, [SDV]Life Sciences [q-bio], Inflammation, Pharmacology, MESH: Monocytes, Biochemistry, Monocytes, Workflow, MESH: Workflow, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tandem Mass Spectrometry, Physiology (medical), Lipidomics, medicine, Humans, THP1 cell line, Viability assay, Phytofurans, Cytotoxicity, Furans, 2. Zero hunger, Phytoprostanes, Prostaglandins, UHPLC-QqQ-ESI-MS/MS, Cyclooxygenase 2, MESH: Humans, Chemistry, MESH: Furans, MESH: Tandem Mass Spectrometry, Pathophysiology, 030104 developmental biology, lipids (amino acids, peptides, and proteins), medicine.symptom, MESH: Cyclooxygenase 2, MESH: Lipopolysaccharides, 030217 neurology & neurosurgery, MESH: Lipidomics
Abstract

Inflammation is a fundamental pathophysiological process which occurs in the course of several diseases. The present work describes the capacity of phytoprostanes (PhytoPs) and phytofurans (PhytoFs) (plant oxylipins), present in plant-based foods, to modulate inflammatory processes mediated by prostaglandins (PGs, human oxylipins) in lipopolysaccharide (LPS)-stimulated THP-1 monocytic cells, through a panel of 21 PGs and PG's metabolites, analyzed by UHPLC-QqQ-ESI-MS/MS. Also, the assessment of the cytotoxicity of PhytoPs and PhytoFs on THP-1 cells evidenced percentages of cell viability higher than 90% when treated with up to 100 μM. Accordingly, 50 μM of the individual PhytoPs and PhytoFs 9-F-PhytoP, 9-epi-9-F-PhytoP, ent-16-F-PhytoP, ent-16-epi-16-F-PhytoP, ent-9-D-PhytoP, 16-B-PhytoP, 9-L-PhytoP, ent-16(RS)-9-epi-ST-Δ-10-PhytoF, ent-9(RS)-12-epi-ST-Δ-13-PhytoF, and ent-16(RS)-13-epi-ST-Δ-9-PhytoF were evaluated on their capacity to modulate the expression of inflammatory markers. The results obtained demonstrated the presence of 7 metabolites (15-keto-PGF, PGF, 11β-PGF, PGE, PGD, PGDM, and PGF) in THP-1 monocytic cells, which expression was significantly modulated when exposed to LPS. The evaluation of the capacity of the individual PhytoPs and PhytoFs to revert the modification of the quantitative profile of PGs induced by LPS revealed the anti-inflammatory ability of 9-F-PhytoP, ent-9-D-PhytoP, 16-B-PhytoP, 9-L-PhytoP, and ent-9(RS)-12-epi-ST-Δ-13-PhytoF, as evidenced by their capacity to prevent the up-regulation of 15-keto-PGF, PGF, PGE, PGF, PGDM, and PGD induced by LPS. These results indicated that specific plant oxylipins can protect against inflammatory events, encouraging further investigations using plant-based foods rich in these oxylipins or enriched extracts, to identify specific bioactivities of the diverse individual molecules, which can be useful for nutrition and health in the frame of well-defined pathophysiological processes., This work was partially funded by the “Fundación Séneca de la Región de Murcia” Grupo de Excelencia 19900/GERM/15, and the Spanish project AGL2017-83386-R from the Spanish Ministry of Science, Innovation, and Universities. This work is included in the framework of the collaboration between the Spanish Research Council (CEBAS-CSIC) and CNRS-University of Montpellier, as “Projets Internationaux de Cooperation Scientifique” (PICS-2015-261141)

Published
2021
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12. Insights into the mechanisms of transport and regulation of the arabidopsis high-affinity K+ transporter HAK51

Author

Francisco Rubio, Alberto Lara, José M. Pardo, Almudena Martínez-Martínez, Jesús Amo, Vicente Martínez, Francisco J. Quintero, Paula Ragel, Manuel Nieves-Cordones, Reyes Ródenas, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire de Recherche en Sciences Végétales (LRSV), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), and Instituto de Bioquimica Vegetal y Fotosintesis (IBVF)

Subjects
0106 biological sciences, Regular Issue, Molecular model, Physiology, Arabidopsis, Transport, Plant Science, Bacillus subtilis, Bioenergetics, Genes, Plant, 01 natural sciences, 03 medical and health sciences, Residue (chemistry), Potassium-Hydrogen Antiporters, Gene Expression Regulation, Plant, Genetics, Arabidopsis thaliana, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Cation Transport Proteins, 030304 developmental biology, 0303 health sciences, Membranes, biology, Chemistry, Arabidopsis Proteins, Genetic Variation, Transporter, Biological Transport, biology.organism_classification, Mutation, Biophysics, Phosphorylation, Function (biology), 010606 plant biology & botany
Abstract

The high-affinity K+ transporter HAK5 from Arabidopsis (Arabidopsis thaliana) is essential for K+ acquisition and plant growth at low micromolar K+ concentrations. Despite its functional relevance in plant nutrition, information about functional domains of HAK5 is scarce. Its activity is enhanced by phosphorylation via the AtCIPK23/AtCBL1-9 complex. Based on the recently published three-dimensionalstructure of the bacterial ortholog KimA from Bacillus subtilis, we have modeled AtHAK5 and, by a mutational approach, identified residues G67, Y70, G71, D72, D201, and E312 as essential for transporter function. According to the structural model, residues D72, D201, and E312 may bind K+, whereas residues G67, Y70, and G71 may shape the selective filter for K+, which resembles that of K+shaker-like channels. In addition, we show that phosphorylation of residue S35 by AtCIPK23 is required for reaching maximal transport activity. Serial deletions of the AtHAK5 C-terminus disclosed the presence of an autoinhibitory domain located between residues 571 and 633 together with an AtCIPK23-dependent activation domain downstream of position 633. Presumably, autoinhibition of AtHAK5 is counteracted by phosphorylation of S35 by AtCIPK23. Our results provide a molecular model for K+ transport and describe CIPK-CBL-mediated regulation of plant HAK transporters.

Published
2021
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13. Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds

Author

Mark Philo, Kateřina Valentová, Ana Rodriguez-Mateos, Pierre Micheau, F. A. T. Barberán, Ville M. Koistinen, Pedro Mena, Gözde Gürdeniz, Marynka Ulaszewska, Sonia de Pascual-Teresa, Christof Van Poucke, László Abrankó, Stéphanie Durand, Conceição Almeida, Dorrain Yanwen Low, Dilip K. Rai, Wiesław Wiczkowski, Letizia Bresciani, Jan Stanstrup, Cristina Andres-Lacueva, Gesine Schmidt, Andreia Bento da Silva, Lars O. Dragsted, Senem Kamiloglu, Claudine Manach, Raúl González-Domínguez, Lucie Petrásková, Kati Hanhineva, Maria Rosário Bronze, Fulvio Mattivi, Esra Capanoglu, Rocío García-Villalba, European Cooperation in Science and Technology, European Commission, European Research Council, Nanyang Technological University, Prime Minister's Office Singapore, Agence Nationale de la Recherche (France), Czech Science Foundation, Universidade Nova de Lisboa, Fundação para a Ciência e a Tecnologia (Portugal), Lantmännen Research Foundation, Academy of Finland, University of Eastern Finland, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Institución Catalana de Investigación y Estudios Avanzados, Consejo Superior de Investigaciones Científicas (España), Fundación Séneca, Gobierno de la Región de Murcia, Norwegian Institute of Food, Fisheries and Aquaculture Research, Carlsberg Foundation, Hungarian Academy of Sciences, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institute of Public Health and Clinical Nutrition, University of Turku, Szent István University, King‘s College London, Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), University Institute of Lisbon (ISCTE), Research Institute for Agricultural, Fisheries and Food (ILVO), University of Barcelona, CIBER de Fragilidad y Envejecimiento Saludable, Teagasc Ashtown Food Research Centre (Teagasc), Istanbul Technical University (ITÜ), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Taif University (TU), Partenaires INRAE, Fdn Edmund Mach, IASMA Research and Innovation Centre, University of Trento [Trento], Norwegian Institute of Food,Fisheries and Aquaculture Research (NOFIMA), IT University of Copenhagen (ITU), Institute of Microbiology of the Czech Academy of Sciences [Prague, Czech Republic] (MBU / CAS), Czech Academy of Sciences [Prague] (CAS), Università degli studi di Parma = University of Parma (UNIPR), Department of Nutrition, Exercise and Sports [Copenhagen], Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Quadram Institute Bioscience [Norwich, U.K.] (QIB), Biotechnology and Biological Sciences Research Council (BBSRC), Fondazione Edmund Mach - Edmund Mach Foundation [Italie] (FEM), Department of Food & Drugs, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Plateforme Exploration du Métabolisme (PFEM), Institut National de la Recherche Agronomique (INRA)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-MetaboHUB-Clermont, MetaboHUB-MetaboHUB, and Institute of Animal Reproduction and Food Research of Polish Academy of Sciences

Subjects
Mean squared prediction error, Computational biology, Plant foods, 01 natural sciences, Plant food bioactive compounds, Analytical Chemistry, 0404 agricultural biotechnology, Metabolomics, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, UHPLC, Faculty of Science, Metabolites, liquid chromatography, Settore CHIM/10 - CHIMICA DEGLI ALIMENTI, 2. Zero hunger, Predicted retention time, 010401 analytical chemistry, External validation, Metabolomikk, 04 agricultural and veterinary sciences, General Medicine, NUTRITION&DIETETICS, 040401 food science, 0104 chemical sciences, Data sharing, Untargeted metabolomics, Predicted retention time, metabolomics, plant food bioactive compounds, metabolites, data sharing, PredRet, liquid chromatography, HPLC, UHPLC, HPLC, PredRet, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Retention time, Food Science
Abstract

Prediction of retention times (RTs) is increasingly considered in untargeted metabolomics to complement MS/MS matching for annotation of unidentified peaks. We tested the performance of PredRet (http://predret.org/) to predict RTs for plant food bioactive metabolites in a data sharing initiative containing entry sets of 29–103 compounds (totalling 467 compounds, >30 families) across 24 chromatographic systems (CSs). Between 27 and 667 predictions were obtained with a median prediction error of 0.03–0.76 min and interval width of 0.33–8.78 min. An external validation test of eight CSs showed high prediction accuracy. RT prediction was dependent on shape and type of LC gradient, and number of commonly measured compounds. Our study highlights PredRet’s accuracy and ability to transpose RT data acquired from one CS to another CS. We recommend extensive RT data sharing in PredRet by the community interested in plant food bioactive metabolites to achieve a powerful community-driven open-access tool for metabolomics annotation., The authors acknowledge networking support by the European Cooperation in Science and Technology (COST) Action FA 1403 POSITIVe (Interindividual Variation in Response to Consumption of Plant Food Bioactives and Determinants Involved). Dorrain Low has received the support of EU H2020 in the framework of the FP7-Marie Curie-COFUND People Programme, through award of the AgreenSkills+ Fellowship (grant number 609398) and Nanyang Technological University, Singapore, through award of the Presidential Postdoctoral Fellowship (grant number 001991-00001). The MetaboHUB French infrastructure has supported the INRAE platform (PFEM, MetaboHUB-Clermont) involved in this work (grant number ANR-INBS-0010). Kateřina Valentová and Lucie Petrásková acknowledge financial support from the Czech Science Foundation (grant number 19-00043S). The Faculty of Pharmacy of Lisbon University acknowledges FUNDAÇÃO PARA A CIÊNCIA E TECNOLOGIA and PORTUGAL 2020 for financial support of the Portuguese Mass Spectrometry Network (grant number LISBOA-01-0145-FEDER-402-022125). Kati Hanhineva and Ville Koistinen have received funding from the Academy of Finland (grant numbers 277986 and 312550), Lantmännen Foundation and EU H2020 FP7-Marie Curie-COFUND MoRE Programme (grant number 754412). Biocenter Finland has financially supported the LC-MS metabolomics unit of University of Eastern Finland. Cristina Andres-Lacueva and Raúl González-Domínguez thank CIBERFES and ISCIII projects AC19/00111 and AC19/00096 (co-funded by FEDER Program from EU, “A way to make Europe”), Generalitat de Catalunya’s Agency AGAUR (grant number 2017SGR1546), “Juan de la Cierva” program from MINECO (grant number IJC2019-041867-I) and ICREA Academia award 2018. Francisco A. Tomás-Barberán has received financial support from the Spanish National Research program (grant numbers AGL-2015-73107-EXP/AEI, CSIC 201870E014) and Fundación Seneca Región de Murcia (grant number 19900/GERM/15). Gesine Schmidt acknowledges support through the Norwegian Agriculture and Food Industry Research Funds (grant number 262300). Lars Dragsted and Jan Stanstrup thank the Carlsberg Foundation for a Semper Ardens grant to support this work. László Abrankó acknowledges the Hungarian Academy of Sciences for the János Bolyai Scholarship, and support of the EU and ESF co-financed project of SZIU (grant number EFOP-3.6.3-VEKOP-16-2017-00005). Sonia de Pascual-Teresa thanks the Spanish MINECO for financial support (grant number AGL2016-76832-R). Dilip K. Rai acknowledges Teagasc for the financial support through the Walsh Fellowship (grant number 2016038).

Published
2021
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14. Unravelling the capacity of hydroxytyrosol and its lipophenolic derivates to modulate the H2O2-induced isoprostanoid profile of THP-1 monocytes by UHPLC-QqQ-MS/MS lipidomic workflow

Author

Angel Gil-Izquierdo, Raúl Domínguez-Perles, Federico Fanti, Thierry Durand, Agustín Javier Simonelli-Muñoz, Céline Crauste, Juana Inés Gallego-Gómez, Espérance Moine, Carolina Alemán-Jiménez, Sonia Medina, Universidad Católica San Antonio de Murcia (UCAM), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Facoltà di Bioscienze e tecnologie agro-alimentari e ambientali - Faculty of Bioscience and Agro-Food and Environmental Technology [Teramo], Universita degli studi di Teramo - University of Teramo [Italie] (UNITE), Universidad de Almería (UAL), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Fundación Séneca, Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), and European Commission

Subjects
Inflammation, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, medicine.disease_cause, Isoprostanoids, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Hydroxytyrosol, In vitro models, Lipophenols, Oxidative stress, Lipidomics, medicine, THP1 cell line, Spectroscopy, 030304 developmental biology, 0303 health sciences, Cellular redox, In vitro, chemistry, Biochemistry, 030220 oncology & carcinogenesis, medicine.symptom, Olive oil
Abstract

Presently, the attention given to natural substances to counteract damage produced by oxidative stress (OS) has risen sharply. In this scenario, hydroxytyrosol (HT) derivatives, formed as a result of HT conjugation with fatty acids (FAs) (lipophenols), have been recently described in foodstuffs such as extra virgin olive oil, as being powerful bioactive compounds with a higher activity than the unesterified phenolic compound. The present work describes the capacity of HT lipophenols to act on the course of OS and secondary inflammatory processes, based on their capacity to modulate the isoprostanoid profile induced by HO in THP-1 monocytic cells. A UHPLC-QqQ-ESI-MS/MS-based lipidomics workflow was applied over a range of 37 human oxylipins. The main outcomes retrieved suggest both HT and HT-lipophenols as regulators of the cellular redox balance, acting as pro-oxidants in vitro, which is highly dependent on the experimental conditions. Our outcomes suggest the anti-inflammatory potential of both HT and HT-lipophenols, where the type of the FAs on the HT core appears to be critical for defining the bioactivity of lipophenols, highlighting that a lipidomic approach, with the simultaneous analysis of multiple oxylipins, is critical for the understanding of the bioactivity of lipophenols on isoprostanoid generation and hence, on pathophysiological processes., This work was partially funded by the “Fundación Séneca de la Región de Murcia” Grupo de Excelencia 19900/GERM/15 and the Spanish project AGL2017-83386-R-AEI/FEDER, UE from the Spanish Ministry of Science, Innovation, and Universities. SM was supported by a Postdoctoral Contract (Saavedra-Fajardo 21078/SF/19) from the Agency for Science and Technology of the Región de Murcia – “Fundación Séneca” (Spain)

Published
2021
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15. Pedigree analysis of 220 almond genotypes reveals two world mainstream breeding lines based on only three different cultivars

Author

Felipe Pérez de los Cobos, Pedro J. Martínez-García, Agustí Romero, Xavier Miarnau, Iban Eduardo, Werner Howad, Mourad Mnejja, Federico Dicenta, Rafel Socias i Company, Maria J. Rubio-Cabetas, Thomas M. Gradziel, Michelle Wirthensohn, Henri Duval, Doron Holland, Pere Arús, Francisco J. Vargas, Ignasi Batlle, Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Generalitat de Catalunya, European Commission, Institute of Agrifood Research and Technology (IRTA), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centre for Research in Agricultural Genomics (CRAG), Centro de Investigacion y Tecnologia Agroalimentaria de Aragon (CITA), University of California, University of Adelaide, Génétique et Amélioration des Fruits et Légumes (GAFL), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Newe Ya’ar Research Center, Agricultural Research Organization, Producció Vegetal, and Fructicultura

Subjects
Fitomejoramiento, 0106 biological sciences, 0301 basic medicine, COANCESTRY, CALIFORNIA, Genotipos, Plant Science, Variación genética, Horticulture, Biology, ISOZYME VARIABILITY, 01 natural sciences, Biochemistry, Article, Plant breeding, 03 medical and health sciences, RELATEDNESS, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Inbreeding depression, Genetics, Inbreeding, Cultivar, Genetic variability, Allele, PEACH, 2. Zero hunger, AMYGDALUS BATSCH, Prunus dulcis, [SDV.BV.AP]Life Sciences [q-bio]/Vegetal Biology/Plant breeding, 030104 developmental biology, Agronomy, GERMPLASM, Genetic gain, Genetic structure, Tree breeding, GENETIC DIVERSITY, FOUNDING CLONES, GENOMICS, 010606 plant biology & botany, Biotechnology
Abstract

Loss of genetic variability is an increasing challenge in tree breeding programs due to the repeated use of a reduced number of founder genotypes. However, in almond, little is known about the genetic variability in current breeding stocks, although several cases of inbreeding depression have been reported. To gain insights into the genetic structure in modern breeding programs worldwide, marker-verified pedigree data of 220 almond cultivars and breeding selections were analyzed. Inbreeding coefficients, pairwise relatedness, and genetic contribution were calculated for these genotypes. The results reveal two mainstream breeding lines based on three cultivars: “Tuono”, “Cristomorto”, and “Nonpareil”. Descendants from “Tuono” or “Cristomorto” number 76 (sharing 34 descendants), while “Nonpareil” has 71 descendants. The mean inbreeding coefficient of the analyzed genotypes was 0.041, with 14 genotypes presenting a high inbreeding coefficient, over 0.250. Breeding programs from France, the USA, and Spain showed inbreeding coefficients of 0.075, 0.070, and 0.037, respectively. According to their genetic contribution, modern cultivars from Israel, France, the USA, Spain, and Australia trace back to a maximum of six main founding genotypes. Among the group of 65 genotypes carrying the Sf allele for self-compatibility, the mean relatedness coefficient was 0.125, with “Tuono” as the main founding genotype (24.7% of total genetic contribution). The results broaden our understanding about the tendencies followed in almond breeding over the last 50 years and will have a large impact into breeding decision-making process worldwide. Increasing current genetic variability is required in almond breeding programs to assure genetic gain and continuing breeding progress., This research was supported in part by grants from the Ministry of Economy and Competitiveness MINECO/FEDER Projects RTA 2017-00084-00-00 and CERCA Program Generalitat of Catalonia. FPC acknowledges a grant from the Spanish MINECO.

Published
2021
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16. The Salt Sensitivity Induced by Disruption of Cell Wall-Associated Kinase 1 (SlWAK1) Tomato Gene Is Linked to Altered Osmotic and Metabolic Homeostasis

Author

Francisco B. Flores, Maria C. Bolarin, Fernando J. Yuste-Lisbona, Elisabeth Esch, Isabel Egea, Stéphanie Drevensek, Victoriano Meco, Fredy Barneche, Rafael Lozano, Ana Ortíz-Atienza, Wim H. Vriezen, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centro de Investigación en Biotecnología Agroalimentaria, Universidad de Almería (UAL), Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, 0301 basic medicine, Osmosis, [SDV]Life Sciences [q-bio], Mutant, 01 natural sciences, Salt Stress, lcsh:Chemistry, Solanum lycopersicum, Cell Wall, Gene Expression Regulation, Plant, Homeostasis, lcsh:QH301-705.5, Spectroscopy, metabolites, Plant Proteins, 2. Zero hunger, Chlorosis, biology, Chemistry, food and beverages, General Medicine, Salt Tolerance, Sucrose transport, Computer Science Applications, Cell biology, ion stress, Osmotic shock, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, insertional mutant, Physical and Theoretical Chemistry, Molecular Biology, Abiotic stress, Organic Chemistry, fungi, Wild type, Biotic stress, biology.organism_classification, fruit yield, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, osmotic stress, Solanum, 010606 plant biology & botany, Transcription Factors
Abstract

Tomato cell wall-associated kinase 1 (SlWAK1) has only been studied in biotic stress response and hence its function in abiotic stress remains unknown. In a screening under salinity of an insertional mutant collection of tomato (Solanum lycopersicum L.), a mutant exhibiting lower degree of leaf chlorosis than wild type (WT) together with reduced leaf Na+ accumulation was selected. Genetic analysis of the mutation revealed that a single T-DNA insertion in the SlWAK1 gene was responsible of the mutant phenotype. Slwak1 null mutant reduced its shoot growth compared with WT, despite its improved Na+ homeostasis. SlWAK1 disruption affected osmotic homeostasis, as leaf water content was lower in mutant than in WT under salt stress. In addition, Slwak1 altered the source-sink balance under salinity, by increasing sucrose content in roots. Finally, a significant fruit yield reduction was found in Slwak1 vs. WT under long-term salt stress, mainly due to lower fruit weight. Our results show that disruption of SlWAK1 induces a higher sucrose transport from source leaf to sink root, negatively affecting fruit, the main sink at adult stage.

Published
2020
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17. Evaluation of the Probiotic Properties and the Capacity to Form Biofilms of Various Lactobacillus Strains

Author

Sophie Lafay, Philippe Langella, Virgile Guéneau, Angel Gil-Izquierdo, Pierre-Yves Mousset, Sonia Medina, Romain Briandet, Julien Deschamps, Luis G. Bermúdez-Humarán, Celia Chamignon, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Indigo Therapeutics, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), and Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)

Subjects
0301 basic medicine, Microbiology (medical), [SDV]Life Sciences [q-bio], 030106 microbiology, Microbiology, Article, biofilm, law.invention, 03 medical and health sciences, Probiotic, law, Virology, Lactobacillus, medicine, lcsh:QH301-705.5, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, Gastrointestinal tract, Intestinal permeability, biology, stress tolerance, Biofilm, biology.organism_classification, medicine.disease, In vitro, 3. Good health, 030104 developmental biology, Enzyme, chemistry, lcsh:Biology (General), probiotics, permeability, Bacteria
Abstract

Over the last 20 years, Lactobacillus species inhabiting the gastrointestinal tract (GIT) have received much attention, and their health-promoting properties are now well-described. Probiotic effects cannot be generalized, and their uses cover a wide range of applications. It is thus important to proceed to an accurate selection and evaluation of probiotic candidates. We evaluate the probiotic potential of six strains of Lactobacillus in different in vitro models representing critical factors of either survival, efficacy, or both. We characterized the strains for their ability to (i) modulate intestinal permeability using transepithelial electrical resistance (TEER), (ii) form biofilms and resist stressful conditions, and (iii) produce beneficial host and/or bacteria metabolites. Our data reveal the specificity of Lactobacillus strains to modulate intestinal permeability depending on the cell type. The six isolates were able to form spatially organized biofilms, and we provide evidence that the biofilm form is beneficial in a strongly acidic environment. Finally, we demonstrated the ability of the strains to produce &gamma, aminobutyric acid (GABA) that is involved in the gut-brain axis and beneficial enzymes that promote the bacterial tolerance to bile salts. Overall, our study highlights the specific properties of Lactobacillus strains and their possible applications as biofilms.

Published
2020
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18. Innovative soil fertility management by stakeholder engagement in the Chókwè irrigation scheme (Mozambique)

Author

Gonzalo G. Barberá, Higino Fabiao Tamele, Joris de Vente, Sebastião Famba, Maite Sanchez‐Reparaz, Dominique Rollin, Aleksandra Dolinska, Jean-Emmanuel Rougier, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), UNIVERSIDADE EDUARDO MONDLANE MAPUTO MOZ, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Gestion de l'Eau, Acteurs, Usages (UMR G-EAU), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-AgroParisTech-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), LISODE MONTPELLIER FRA, and European Commission within the 7th Framework Programme - 265471

Subjects
2. Zero hunger, Participatory planning, business.industry, Process (engineering), 0208 environmental biotechnology, Environmental resource management, COMMUNITIES OF PRACTICE, MOZAMBIQUE, Soil Science, Stakeholder engagement, Citizen journalism, Collaborative learning, 04 agricultural and veterinary sciences, 02 engineering and technology, 15. Life on land, COMMUNAUTES DE PRATIQUE, 020801 environmental engineering, Soil management, Agrarian society, Sustainability, [SDE]Environmental Sciences, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Business, Agronomy and Crop Science
Abstract

Appropriate soil fertility management plays an important role in irrigated systems and can contribute to reducing the yield gap. To that end, abiotic, biotic, management and socio-economic factors need to be considered and participatory approaches need to be implemented to ensure the sustainability of the interventions. Our objective is to analyse a participatory process conducted in the Chokwe Irrigation Scheme (Mozambique) to trigger agronomic innovation in soil fertility management. Through a method combining interviews with 31 farmers, soil sampling and the organization of communities of practice we studied actual agrarian practices and farmers' knowledge about soil fertility management as well as the social and physical context. This information was the basis for selecting an association in order to promote the innovation process. A participatory planning of the innovation test was conducted. The whole process was evaluated by farmers. Adoption of the majority of the practices is limited mainly by factors related to the socio-economic status of farmers and not to the lack of knowledge. Farmers did not highly value the participatory process itself, but valued the learning-by-doing process and the collaboration with researchers. We consider that the approach increased collective learning and this process triggered the innovation dynamics. Copyright © 2016 John Wiley & Sons, Ltd.

Published
2020
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19. Oxylipin regulation by phenolic compounds from coffee beverage: Positive outcomes from a randomized controlled trial in healthy adults and macrophage derived foam cells

Author

Rafael Álvarez, Camille Oger, Oscar J. Lara-Guzmán, Jean-Marie Galano, Angel Gil-Izquierdo, Katalina Muñoz-Durango, Thierry Durand, Sonia Medina, Natalia Zuluaga, Vidarium - Nutrition, Health and Wellness Research Center, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Adult, 0301 basic medicine, Macrophage foam cells, Antioxidant, medicine.medical_treatment, Inflammation, Urine, medicine.disease_cause, Coffee, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, In vivo, Physiology (medical), medicine, Humans, Food science, Oxylipins, Foam cell, chemistry.chemical_classification, oxLDL, Chemistry, Coffee beverage, Macrophages, Oxylipin, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Atherosclerosis, 3. Good health, 030104 developmental biology, lipids (amino acids, peptides, and proteins), Chlorogenic acids, Chlorogenic Acid, medicine.symptom, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery, Oxidative stress, Foam Cells, Polyunsaturated fatty acid
Abstract

International audience; Oxylipins are considered biomarkers related to cardiovascular diseases (CVDs). They are generated in vivo via the oxygenation of polyunsaturated fatty acids as a result of oxidative stress and inflammation. Oxylipins are involved in vascular functions and are produced during foam cell formation in atherogenesis. Additionally, the consumption coffee is associated with the regulation on a particular oxylipin group, the F2t-isoprostanes (F2t-IsoPs). This function has been attributed to the chlorogenic acids (CGAs) from the coffee beverage. Considering the anti-inflammatory and antioxidant properties of CGAs, we evaluated the effects of two types of coffee that provided 787 mg CGAs/day (Coffee A) and 407 mg CGAs/day (Coffee B) by reducing 35 selected oxylipins in healthy subjects. Furthermore, we assessed the effect of CGAs on the cellular proatherogenic response in foam cells by using an oxidized LDL (oxLDL)-macrophage interaction model. After eight weeks of coffee consumption, the contents of 12 urine oxylipins were reduced. However, the effect of Coffee A showed a stronger decrease in IsoPs, dihomo-IsoPs, prostaglandins (PGs) and PG metabolites, probably due to its higher content of CGAs. Neither of the two coffees reduced the levels of oxLDL. Moreover, the in vitro oxylipin induction by oxLDL on foam cells was ameliorated by phenolic acids and CGAs, including the inhibition of IsoPs and PGs by caffeoylquinic and dicaffeoylquinic acids, respectively, while the phenolic acids maintained both antioxidant and anti-inflammatory activities. These findings suggest that coffee antioxidants are strong regulators of oxylipins related to CVDs. The clinical trial was registered on the International Clinical Trials Registry Platform, WHO primary registry (RPCEC00000168).

Published
2020
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20. Why interindividual variation in response to consumption of plant food bioactives matters for future personalised nutrition

Author

Baukje de Roos, Ana Rodriguez-Mateos, Rikard Landberg, Claudine Manach, Eileen R. Gibney, Francisco A. Tomás-Barberán, Dragan Milenkovic, Tom Van de Wiele, Christine Morand, María Teresa García-Conesa, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), The Rowett Research Institute, University of Aberdeen, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), UCD Institute of Food and Health, University College Dublin (UCD), Department of Biology and Biological Engineering, Food and Nutrition Science, Chalmers University of Technology [Gothenburg, Sweden], Deparment of Nutritional Sciences, School of Life Course Sciences, Faculty of life Sciences and Medicine, King‘s College London, Center for Microbial Ecology and Technology (CMET), Universiteit Gent = Ghent University [Belgium] (UGENT), Faculty of Bioscience Engineering at Ghent University, Cost Action - European Cooperation in Science and Technology FA1403, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centro de Edafología y Biología Aplicada del Segura (CEBAS-CSIC), Chalmers University of Technology, King’s College London, and Universiteit Gent = Ghent University (UGENT)

Subjects
0301 basic medicine, Male, Phytochemicals, Medicine (miscellaneous), Biological Availability, 030209 endocrinology & metabolism, Biology, Gut flora, Plant foods, Interindividual variability, 03 medical and health sciences, 0302 clinical medicine, Nutrigenomics, Environmental health, medicine, Humans, Nutritional Physiological Phenomena, Precision Medicine, Beneficial effects, 2. Zero hunger, Cardiometabolic risk, Consumption (economics), 030109 nutrition & dietetics, Nutrition and Dietetics, Genome, Human, Research, Cardiometabolic health, Food phytochemicals, medicine.disease, biology.organism_classification, Intervention studies, Obesity, 3. Good health, Diet, Gastrointestinal Microbiome, Variation (linguistics), Biological Variation, Population, Heart Disease Risk Factors, Metabolome, Female, Nutritive Value, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

Part of: Nutrition Society Spring Meeting 2019 Conference on ‘Inter-individual differences in the nutrition response: from research to recommendations’; Food phytochemicals are increasingly considered to play a key role in the cardiometabolic health effects of plant foods. However, the heterogeneity in responsiveness to their intake frequently observed in clinical trials can hinder the beneficial effects of these compounds in specific subpopulations. A range of factors, including genetic background, gut microbiota, age, sex and health status, could be involved in these interindividual variations; however, the current knowledge is limited and fragmented. The European network, European Cooperation in Science and Technology (COST)-POSITIVe, has analysed, in a systematic way, existing knowledge with the aim to better understand the factors responsible for the interindividual variation in response to the consumption of the major families of plant food bioactives, regarding their bioavailability and bioefficacy. If differences in bioavailability, likely reflecting differences in human subjects’ genetics or in gut microbiota composition and functionality, are believed to underpin much of the interindividual variability, the key molecular determinants or microbial species remain to be identified. The systematic analysis of published studies conducted to assess the interindividual variation in biomarkers of cardiometabolic risk suggested some factors (such as adiposity and health status) as involved in between-subject variation. However, the contribution of these factors is not demonstrated consistently across the different compounds and biological outcomes and would deserve further investigations. The findings of the network clearly highlight that the human subjects’ intervention studies published so far are not adequate to investigate the relevant determinants of the absorption/metabolism and biological responsiveness. They also emphasise the need for a new generation of intervention studies designed to capture this interindividual variation.

Published
2020
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21. Sorting out the phytoprostane and phytofuran profile in vegetable oils

Author

Jean-Marie Galano, Federico Ferreres, Raúl Domínguez-Perles, Ángel Abellán, Angel Gil-Izquierdo, Thierry Durand, Alexander Guy, Camille Oger, Daniel León, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Spectrometry, Mass, Electrospray Ionization, Plant oxylipins, Phytochemicals, SAFFLOWER SEED, Saponification, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Tandem Mass Spectrometry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Plant Oils, Oxylipins, Food science, Furans, Chromatography, High Pressure Liquid, α-linolenic acid, 2. Zero hunger, Autoxidation, Chemistry, 010401 analytical chemistry, α-Linolenic acid, Isoprostanes, 0104 chemical sciences, Bioavailability, 030104 developmental biology, Arachidonic acid, Vegetable oils, Nutritive Value, Food Analysis, UHPLC-ESI-QqQ-MS/MS, Saponification, Food Science
Abstract

Phytoprostanes (PhytoPs) and phytofurans (PhytoFs) are prostaglandin-like compounds, contributing to defense signaling and prevention of cellular damage. These plant oxylipins result from autoxidation of α-linolenic acid (ALA) and have been proposed as new bioactive compounds due to their structural analogies with isoprostanes (IsoPs) and prostanoids derived from arachidonic acid in mammals, which have demonstrated diverse biological activities. The present work assesses a wide range of vegetable oils - including extra virgin olive oils (n = 7) and flax, sesame, argan, safflower seed, grapeseed, and palm oils - for their content of PhytoPs and PhytoFs. Flax oil displayed the highest concentrations, being notable the presence of 9-epi-9-D1t-PhytoP, 9-D1t-PhytoP, 16-B1-PhytoP, and 9-L1-PhytoP (7.54, 28.09, 28.67, and 19.22 μg mL−1, respectively), which contributed to a total PhytoPs concentration of 119.15 μg mL−1, and of ent-16-(RS)-9-epi-ST-Δ14-10-PhytoF (21.46 μg mL−1). Palm and grapeseed oils appeared as the most appropriate negative controls, given the near absence of PhytoPs and PhytoFs (lower than 0.15 μg mL−1). These data inform on the chance to develop nutritional trials using flax and grapeseed oils as food matrices that would provide practical information to design further assays intended to determine the actual bioavailability/bioactivity in vivo.

Published
2018
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22. Effect of Coffee and Cocoa-Based Confectionery Containing Coffee on Markers of DNA Damage and Lipid Peroxidation Products: Results from a Human Intervention Study

Author

Donato Angelino, Daniela Martini, Letizia Gigliotti, Marisa Porrini, Federico Ferreres, Thierry Durand, Alexandre Guy, Daniele Del Rio, Riccardo C. Bonadonna, Furio Brighenti, Monica Antonini, Michele Tassotti, Alessandra Dei Cas, Raúl Domínguez-Perles, Patrizia Riso, Mirko Marino, Alice Rosi, Sonia Medina, Hans Gottfried-Genieser, Cristian Ricci, Angel Gil-Izquierdo, Francesca Scazzina, Pedro Mena, Cristian Del Bo, Camille Oger, Università degli Studi di Milano [Milano] (UNIMI), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of Parma = Università degli studi di Parma [Parme, Italie], Universita degli studi di Teramo - University of Teramo [Italie] (UNITE), Universität Leipzig [Leipzig], Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Universidad Católica San Antonio de Murcia (UCAM), and Soremartec Italia

Subjects
Male, 0301 basic medicine, [SDV]Life Sciences [q-bio], Tassotti, Target groups, Ricci, medicine.disease_cause, MESH: Lipid Peroxidation, M, Lipid peroxidation, Martini, chemistry.chemical_compound, A, Tandem Mass Spectrometry, oxidative stress, MESH: Cyclic GMP, TX341-641, Oger, Food science, Chocolate, Cyclic GMP, Chromatography, High Pressure Liquid, Gigliotti, Cross-Over Studies, Angelino, MESH: Oxidative Stress, Nutrition and Dietetics, Guy, lipid peroxidation, L, 3. Good health, 8-Hydroxy-2'-Deoxyguanosine, MESH: Young Adult, D, Female, S, Guanine, Medina, Rosi, DNA damage, MESH: 8-Hydroxy-2'-Deoxyguanosine, coffee, MESH: Comet Assay, Biology, Article, MESH: Cross-Over Studies, Young Adult, C, 03 medical and health sciences, comet assay, medicine, Humans, ddc:610, MESH: Chocolate, MESH: Chromatography, High Pressure Liquid, Domínguez-Perles, R, MESH: Guanine, MESH: DNA Damage, MESH: Humans, 030109 nutrition & dietetics, Nutrition. Foods and food supply, et al. Effect of Coffee and Cocoa-Based Confectionery coffee, MESH: Tandem Mass Spectrometry, MESH: Coffee, DNA oxidation, Intervention studies, MESH: Male, Comet assay, 030104 developmental biology, chemistry, randomized controlled trial, MESH: Biomarkers, Espresso coffee, MESH: Female, Biomarkers, Oxidative stress, Food Science
Abstract

The effect of coffee and cocoa on oxidative damage to macromolecules has been investigated in several studies, often with controversial results. This study aimed to investigate the effect of one-month consumption of different doses of coffee or cocoa-based products containing coffee on markers of DNA damage and lipid peroxidation in young healthy volunteers. Twenty-one volunteers were randomly assigned into a three-arm, crossover, randomized trial. Subjects were assigned to consume one of the three following treatments: one cup of espresso coffee/day (1C), three cups of espresso coffee/day (3C), and one cup of espresso coffee plus two cocoa-based products containing coffee (PC) twice per day for 1 month. At the end of each treatment, blood samples were collected for the analysis of endogenous and H2O2-induced DNA damage and DNA oxidation catabolites, while urines were used for the analysis of oxylipins. On the whole, four DNA catabolites (cyclic guanosine monophosphate (cGMP), 8-OH-2′-deoxy-guanosine, 8-OH-guanine, and 8-NO2-cGMP) were detected in plasma samples following the one-month intervention. No significant modulation of DNA and lipid damage markers was documented among groups, apart from an effect of time for DNA strand breaks and some markers of lipid peroxidation. In conclusion, the consumption of coffee and cocoa-based confectionery containing coffee was apparently not able to affect oxidative stress markers. More studies are encouraged to better explain the findings obtained and to understand the impact of different dosages of these products on specific target groups., This study was partially funded by Soremartec Italia S.r.l. (Alba, Italy). The sponsor approved the final trial protocol but was not involved in any stage of the study as well as in the drafting of the manuscript.

Published
2021
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23. Soil aggregate stability in Mediterranean and tropical agro-ecosystems: effect of plant roots and soil characteristics

Author

Mario Villatoro, James Metayer, Yves Le Bissonnais, Sylvain Huon, Iván Prieto, Jérome Nespoulous, Catherine Roumet, Alexia Stokes, Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL), Centro de Edafologia y Biologia Aplicada del Segura, Université Paul-Valéry - Montpellier 3 (UPVM), Botanique et Modélisation de l'Architecture des Plantes et des Végétations (UMR AMAP), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris), Institut National de la Recherche Agronomique (INRA)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Centro de Investigaciones Agronómicas (CIAS), Universidad Nacional de Costa Rica, Agence Nationale de la Recherche in France (Ecosfix) [ANR-10-STRA-003-001], ANR-10-STRA-0003,ECOSFIX,Services écosystémiques des racines – redistribution hydrique, séquestration du carbone et fixation du sol(2010), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut de Recherche pour le Développement (IRD [ Madagascar])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université Paul-Valéry - Montpellier 3 (UM3), Université Paul-Valéry - Montpellier 3 (UM3), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut d'écologie et des sciences de l'environnement de Paris (IEES (UMR_7618 / UMR_D_242 / UMR_A_1392 / UM_113) ), Université Paul-Valéry - Montpellier 3 (UPVM)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)

Subjects
0106 biological sciences, Soil biodiversity, [SDV]Life Sciences [q-bio], Soil Science, Soil science, Plant Science, Aggregate stability, complex mixtures, 01 natural sciences, 2. Zero hunger, Soil organic carbon, Soil organic matter, Soil morphology, 04 agricultural and veterinary sciences, Soil carbon, Root traits, 15. Life on land, Soil type, Soil structure, Agronomy, Soil depth, Land use, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Environmental science, Soil horizon, Soil fertility, 010606 plant biology & botany
Abstract

Our aim was to determine the effect of soil characteristics and root traits on soil aggregate stability at an inter- and intra-site scale in a range of agro-ecosystems. We also evaluated the effect of soil depth and the type of land use on aggregate stability. Soil aggregate stability, soil physicochemical properties and fine root traits were measured along land use gradients (from monocultures to agroforestry systems and forests), at two soil depths at four sites (Mediterranean and tropical climates) with contrasting soils (Andosol, Ferralsol, Leptosol and Fluvisol). Aggregate stability was much lower in deep than in surface soil layers, likely linked to lower soil organic carbon (SOC) and lower root mass density (RMD). Locally, and consistently in all sites, land use intensification degrades soil aggregate stability, mainly in surface soil layers. Soil organic carbon, cation exchange capacity and root traits: water-soluble compounds, lignin and medium root length proportion were the most important drivers of aggregate stability at the inter-site level, whereas SOC, root mass and root length densities (RMD, RLD) were the main drivers at the intra-site level. Overall, the data suggest different controls on soil aggregate stability globally (soil) and locally (roots). Conversion from forests to agricultural land will likely lead to greater C losses through a loss of aggregate stability and increased soil erosion.

Published
2017
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24. Urinary oxylipin signature as biomarkers to monitor the allograft function during the first six months post-renal transplantation

Author

Valérie Bultel-Poncé, Ignacio De las Heras-Gómez, Angel Gil-Izquierdo, Thierry Durand, Federico Ferreres, Teresa Casas-Pina, Pedro Martínez-Hernández, Jean-Marie Galano, Luisa Jimeno, Santiago Llorente, Sonia Medina, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Hospital Univeristario Virgen de la Arrixaca, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Nephrology, medicine.medical_specialty, MESH: Oxylipins, Urinary system, [SDV]Life Sciences [q-bio], MESH: Allografts, Isoprostanes, Prostanoids, Urine, Biochemistry, Gastroenterology, MESH: Kidney Transplantation, 03 medical and health sciences, 0302 clinical medicine, Tandem Mass Spectrometry, Physiology (medical), Internal medicine, medicine, Humans, Oxylipins, chemistry.chemical_classification, Inflammation, Kidney, MESH: Humans, business.industry, MESH: Tandem Mass Spectrometry, Oxylipin, Allografts, Kidney Transplantation, 3. Good health, Transplantation, 030104 developmental biology, medicine.anatomical_structure, Renal transplant, chemistry, Thromboxanes, Oxidative stress, Lipidomics, MESH: Biomarkers, business, 030217 neurology & neurosurgery, Biomarkers, Polyunsaturated fatty acid
Abstract

International audience; Oxylipins such as isoprostanes (IsoPs), prostaglandins (PGs) and thromboxanes (TXs) are lipid mediators derived from the oxidation of polyunsaturated fatty acids, which regulate the magnitude of oxidative stress and inflammation processes and play an important role in pathophysiological processes in the kidney. A total of 36 oxylipins were analyzed by UHPLC-QqQ-MS/MS in the urine of 41 renal recipients from cadaveric donors of the Nephrology Unit of the University Hospital Virgen de la Arrixaca during the first six months after renal transplantation, in order to investigate several candidate oxylipins as more accurate and predictive biomarkers in renal transplantation than classical biological variables. A decrease in nine PGs, mostly from the AA-D pathway (p

Published
2019
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25. Impact of foods and dietary supplements containing hydroxycinnamic acids on cardiometabolic biomarkers: A systematic review to explore inter-individual variability

Author

Egeria Scoditti, Christos Kontogiorgis, Cristina Andres-Lacueva, Emilie Combet, Mar Garcia-Aloy, Mireia Urpi-Sarda, Georgia-Eirini Deligiannidou, S.A. Palma-Duran, Marika Massaro, Eileen R. Gibney, Margherita Dall'Asta, Letizia Bresciani, Antonio González-Sarrías, Ana Rodriguez-Mateos, Daniela Martini, Christine Morand, Laura Chiavaroli, Pedro Mena, Daniele Del Rio, Viktorija Maksimova, Department of Veterinary Science, Nippon Veterinary and Life Science University, Department of Food & Drug, University of Parma, Department of Nutritional Sciences, Mount Sinai Hospital (MSH), University of Toronto, Grupo de Calidad, Seguridad y Bioactividad de Alimentos Vegetales, Centro de Edafologia y Biologia Aplicada del Segura, College of Medical, Veterinary and Life Sciences, University of Glasgow, Department of Medicine, Laboratory of Hygiene and Environmental Protection, Democritus University of Thrace (DUTH), Istituto di Fisiologia Clinica (IFC), CNR, Department of Applied Pharmacy, Faculty of Medical Sciences, University Goce Delcev (UGD), Department of Nutrition, Food Sciences and Gastronomy, University of Barcelona, XaRTA, INSA·UB, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III (ISC), UCD Institute of Food and Health, University College Dublin [Dublin] (UCD), School of Advanced Studies on Food and Nutrition, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), King’s College London, University of Parma = Università degli studi di Parma [Parme, Italie], Mount Sinai Hospital [Toronto, Canada] (MSH), Instituto de Salud Carlos III [Madrid] (ISC), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), King‘s College London, European Cooperation in Science and Technology (COST) FA1403-POSITIVe, European Cooperation in Science and Technology, Università degli studi di Parma = University of Parma (UNIPR), and Mena, P.

Subjects
0301 basic medicine, Male, Future studies, Caffeoylquinic acids, Hydroxycinnamic acids, Effect modifier, Review, Coffee, Interindividual variability, law.invention, Basic medicine, 0302 clinical medicine, Randomized controlled trial, Other medical sciences, law, Coffees, Risk Factors, Compostos bioactius, 10. No inequality, Randomized Controlled Trials as Topic, 2. Zero hunger, Vegetarianisme, Nutrition and Dietetics, Biological Variation, Individual, Cardiometabolic health, Biological Variation, Middle Aged, Dietary supplements, 3. Good health, Artichoke, Cereals, Polyphenols, Potato, Adult, Aged, Biomarkers, Cardiovascular Diseases, Coumaric Acids, Female, Humans, Metabolic Diseases, Nutritional Status, Nutritive Value, Protective Factors, Risk Reduction Behavior, Young Adult, Diet, Dietary Supplements, Biological sciences, Cardiovascular diseases, Vegetarianism, Polifenols, Alimentation et Nutrition, lcsh:Nutrition. Foods and food supply, medicine.medical_specialty, 030209 endocrinology & metabolism, lcsh:TX341-641, Individual, Population health, Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE, Bioactive compounds, 03 medical and health sciences, Internal medicine, medicine, Food and Nutrition, 030109 nutrition & dietetics, business.industry, artichoke, caffeoylquinic acids, cardiometabolic health, cereals, coffee, dietary supplements, hydroxycinnamic acids, interindividual variability, polyphenols, potato, Malalties cardiovasculars, Chemical sciences, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Food Science
Abstract

Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria. Comparisons were made between RCTs, including assessments based on population health status. Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall effectiveness, which was also found in studies where specific subgroup analyses were performed. Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although future studies in these populations are needed, including those on other potential determinants of inter-individual variability. PROSPERO, registration number CRD42016050790., This article is based upon work from COST Action FA1403—POSITIVe “Interindividual variation in response to consumption of plant food bioactives and determinants involved” supported by COST (European Cooperation in Science and Technology, http://www.cost.eu/).

Published
2019
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26. Medicago truncatula possesses a single Shaker outward K+ channel: functional characterization and roles in planta

Author

Hervé Sentenac, Nicolas Pauly, Manuel Nieves-Cordones, Anne-Aliénor Véry, Isabelle Gaillard, Limin Wang, Julien Thouin, Martin Boeglin, Alice Drain, Biochimie et Physiologie Moléculaire des Plantes (BPMP), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), Departamento de Nutrición Vegetal, Centro de Edafologia y Biologia Aplicada del Segura, Université de Montpellier (UM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), and Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, [SDV]Life Sciences [q-bio], guard cells, Root hair, outward Shaker channels, 01 natural sciences, transpiration control, root hairs, Nod factor, 03 medical and health sciences, Guard cell, canal à potassium, Medicago truncatula, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Shaker, signal intracellulaire, 030304 developmental biology, 0303 health sciences, biology, poil radiculaire, Chemistry, K+ transport to shoots, fungi, Xylem, food and beverages, Depolarization, biology.organism_classification, Cell biology, Membrane repolarization, transpiration des feuilles, Nod factor induced electrical signal, 010606 plant biology & botany
Abstract

SUMMARYThe model legume Medicago truncatula possesses a single outward Shaker K+ channel, while Arabidopsis thaliana possesses two channels of this type, named SKOR and GORK, the former having been shown to play a major role in K+ secretion into the xylem sap in the root vasculature and the latter to mediate the efflux of K+ across the guard cell membrane upon stomatal closure. Here we show that the expression pattern of the single M. truncatula outward Shaker channel, which has been named MtGORK, includes the root vasculature, guard cells and root hairs. As shown by patch-clamp experiments on root hair protoplasts, besides the Shaker-type slowly-activating outwardly-rectifying K+ conductance encoded by MtGORK, a second K+-permeable conductance, displaying fast activation and weak rectification, can be expressed by M. truncatula. A KO mutation resulting in absence of MtGORK activity is shown to weakly reduce K+ translocation to shoots, and only in plants engaged in rhizobial symbiosis, but to strongly affect the control of stomatal aperture and transpitational water loss. In legumes, the early electrical signaling pathway triggered by Nod Factor perception is known to comprise a short transient depolarization of the root hair plasma membrane. In absence of MtGORK functional expression, while the rate of the membrane repolarization is shown to be decreased by about 3 times, this defect is without any consequence on infection thread development and nodule production, indicating that the plant capacity to engage rhizobial symbiosis does not require integrity of the early electrical signaling events.

Published
2019
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27. Phenolic, oxylipin and fatty acid profiles of the Chilean hazelnut (Gevuina avellana): Antioxidant activity and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes

Author

Liudis Leidy Pino Ramos, David Contreras, Alberto Burgos-Edwards, Claudia Mardones, Cristina Theoduloz, Thierry Durand, Raúl Domínguez-Perles, Katherine Márquez, Guillermo Schmeda-Hirschmann, Felipe Jiménez-Aspee, Angel Gil-Izquierdo, Luis Bustamante, Camille Oger, Universidad de Talca, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Universidad de Concepción [Chile]

Subjects
Antioxidant, Coumaric Acids, medicine.medical_treatment, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 01 natural sciences, High-performance liquid chromatography, Antioxidants, Gas Chromatography-Mass Spectrometry, Analytical Chemistry, Lipoxygenase, 0404 agricultural biotechnology, Corylus, Phenols, medicine, Food science, Oxylipins, Phytofurans, Lipase, Chile, Fatty acids, chemistry.chemical_classification, Metabolic Syndrome, biology, Chilean hazelnut, HPLC-MS/MS, Gevuina avellana, 010401 analytical chemistry, Fatty acid, food and beverages, alpha-Glucosidases, 04 agricultural and veterinary sciences, General Medicine, Oxylipin, 040401 food science, 0104 chemical sciences, chemistry, Phytoprostanes, biology.protein, Polyunsaturated fatty acids, Gas chromatography, alpha-Amylases, Phenolics, [CHIM.OTHE]Chemical Sciences/Other, Food Science, Polyunsaturated fatty acid
Abstract

International audience; Roasted cotyledons of the Chilean hazelnut (Gevuina avellana) are appreciated as snacks. The aim of our work was to assess the fatty acid, oxylipin and phenolic composition using gas chromatography (GC) coupled to mass spectrometry (MS), ultra- high performance liquid chromatography (UHPLC) coupled to MS and HPLC coupled to diode array detector (HPLC-DAD). Additionally, various antioxidant activities were assessed. The inhibition of α-glucosidase, α-amylase, lipase, cyclooxygenases-1 and -2 (COX-1/COX-2), and lipoxygenase was determined. The main fatty acids were oleic and 7-hexadecenoic acids. Eight phytoprostanes and three phytofurans were identified and quantified. Hydroxybenzoic and hydroxycinnamic acids were the main phenolic compounds. Oils showed antioxidant activity determined by EPR, and inhibition of COX-1/COX-2. The statistical analysis showed that the roasting does not affect the composition of the samples. The occurrence of oxylipins in this species is reported for the first time. Chilean hazelnuts can be considered a source of health promoting compounds.

Published
2019
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28. Targeting the delivery of dietary plant bioactives to those who would benefit most: from science to practical applications

Author

Nada Knežević, Anna Marja Aura, Baukje de Roos, María Teresa Garcia Conesa, Maria Rosário Bronze, Dragan Milenkovic, Arno Greyling, Tom Van de Wiele, Christine Morand, Aedin Cassidy, Jim Kaput, Ana Rodriguez-Mateos, Paul A. Kroon, Rikard Landberg, Eileen R. Gibney, Zohar Kerem, Claudine Manach, Francisco A. Tomás-Barberán, The Rowett Research Institute, University of Aberdeen, VTT Technical Research Centre of Finland (VTT), Instituto de Biologia Experimental e Tecnológica, Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Centro de Edafología y Biología Aplicada del Segura (CEBAS-CSIC), UCD Institute of Food and Health, University College Dublin (UCD), Unilever Research and Development, Vydiant, The Robert H. Smith Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem, Podravka d.d, Quadram Institute Bioscience, Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Department of Nutritional Sciences, Mount Sinai Hospital (MSH), King’s College London, Center for Microbial Ecology and Technology (CMET), Gent University, Instituto de Biologia Experimental e Tecnológica (IBET), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Chalmers University of Technology [Gothenburg, Sweden], Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Mount Sinai Hospital [Toronto, Canada] (MSH), King‘s College London, Universiteit Gent = Ghent University [Belgium] (UGENT), University of East Anglia [Norwich] (UEA), Quadram Institute Bioscience [Norwich, U.K.] (QIB), Biotechnology and Biological Sciences Research Council (BBSRC), Universiteit Gent = Ghent University (UGENT), and de Roos, B.

Subjects
Agriculture and Food Sciences, 0301 basic medicine, and promotion of well-being, Food industry, Phytochemicals, Medicine (miscellaneous), Review, Gut flora, Cardiovascular, Oral and gastrointestinal, 0302 clinical medicine, Stakeholders, Cost action, Marketing, Cancer, 2. Zero hunger, Potential impact, education.field_of_study, Nutrition and Dietetics, biology, Dietary intake, Diet, Vegetarian, Cardiometabolic diseases, 3. Good health, Cardiovascular Diseases, Alimentation et Nutrition, HEALTH, Healthy diet Cardiometabolic diseases Inter-individual variability in responses Stakeholders Food industry, BIOMARKERS, Population, 030209 endocrinology & metabolism, Health Promotion, METABOLISM, 03 medical and health sciences, Vegetarian, Metabolic Diseases, Inter-individual variability in responses, Food and Nutrition, Humans, Obesity, 3.3 Nutrition and chemoprevention, education, Metabolic and endocrine, Nutrition, Healthy diet, 030109 nutrition & dietetics, Nutrition & Dietetics, business.industry, Prevention, Clinical study design, Prevention of disease and conditions, biology.organism_classification, Diet, Business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

Background A healthy diet and optimal lifestyle choices are amongst the most important actions for the prevention of cardiometabolic diseases. Despite this, it appears difficult to convince consumers to select more nutritious foods. Furthermore, the development and production of healthier foods do not always lead to economic profits for the agro-food sector. Most dietary recommendations for the general population represent a “one-size-fits-all approach” which does not necessarily ensure that everyone has adequate exposure to health-promoting constituents of foods. Indeed, we now know that individuals show a high variability in responses when exposed to specific nutrients, foods, or diets. Purpose This review aims to highlight our current understanding of inter-individual variability in response to dietary bioactives, based on the integration of findings of the COST Action POSITIVe. We also evaluate opportunities for translation of scientific knowledge on inter-individual variability in response to dietary bioactives, once it becomes available, into practical applications for stakeholders, such as the agro-food industry. The potential impact from such applications will form an important impetus for the food industry to develop and market new high quality and healthy foods for specific groups of consumers in the future. This may contribute to a decrease in the burden of diet-related chronic diseases., Key messages Individual differences in ADME (Absorption, Digestion, Metabolism and Excretion) is believed to underpin much of the inter-individual variation in responses.Recent developments in the area of food metabolome databases and fast improvements in innovative metabotyping technologies hold great promise for improved profiling of dietary intake, exposure to individual ingredients, foods and dietary patterns, as well as our ability to identify individual responsiveness.The food industry needs well-defined population clusters or targets in order to be able to design “personalized products”.There are indeed excellent industrial opportunities for foods that modulate gut microbiota, and thereby enable the delivery of food bioactive metabolites.It is currently not clear whether knowledge on individual nutrient needs, based on genetic or metagenomic data, would affect long-term dietary and health behaviours.Data to support the development of dietary recommendations may need to be generated by new n-of-1-based study designs in the future.

Published
2019
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29. Improving the reporting quality of intervention trials addressing the inter-individual variability in response to the consumption of plant bioactives: quality index and recommendations

Author

Marina Nikolić, Marika Massaro, Mar Garcia-Aloy, Geoffrey Istas, Christine Morand, Rocío García-Villalba, Lieselotte Cloetens, Noemi Tejera, Pedro Mena, Maria Rosaria Tumolo, Irena Krga, Mihail Chervenkov, Mireia Urpi-Sarda, Desislava Abadjieva, Antonio González-Sarrías, Francisco A. Tomás-Barberán, Laurent-Emmanuel Monfoulet, Banu Bayram, Margherita Dall'Asta, Aleksandra Konic Ristic, Karen F. Chambers, Rodrigo P. Feliciano, Egeria Scoditti, Institute for Medical Research, University of Belgrade [Belgrade], UCD Institute of Food and Health, University College Dublin [Dublin] (UCD), Laboratory of Food and Health, Centro de Edafologia y Biologia Aplicada del Segura, Department of Nutritional Sciences, Mount Sinai Hospital [Toronto, Canada] (MSH), King‘s College London, Department of Nutrition, Food Sciences and Gastronomy, University of Barcelona, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III [Madrid] (ISC), Human Nutrition Unit, Department of Food and Drugs, Università degli studi di Parma = University of Parma (UNIPR), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Biomedical Nutrition, Pure and Applied Biochemistry, Lund University [Lund], Department of Nutrition and Dietetics, Harokopio University, Institute for research on population and social policies (IRPPS), Faculty of Veterinary Medicine, University of Forestry (UF), Institute of Neurobioloy, Bulgarian Academy of Sciences, Istituto di Fisiologia Clinica (IFC), CNR, Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia [Norwich] (UEA), Institute of Biology and Immunology of Reproduction, Quadram Institute Bioscience [Norwich, U.K.] (QIB), Biotechnology and Biological Sciences Research Council (BBSRC), Division of Cardiology, Pulmonology, and Vascular Medicine, University Hospital Düsseldorf, Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], European Cooperation in Science and Technology (COST) FA1403, Mount Sinai Hospital (MSH), King’s College London, Carlos III Institute, University of Parma, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Lund University, University of East Anglia, Quadram Institute Bioscience, University Düsseldorf, and University of Parma = Università degli studi di Parma [Parme, Italie]

Subjects
0301 basic medicine, Intervention trials, Index (economics), Reporting quality, media_common.quotation_subject, Applied psychology, Phytochemicals, MEDLINE, Medicine (miscellaneous), 030209 endocrinology & metabolism, Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE, Review, Guidelines, Recommendations, Inter-individual variation, 03 medical and health sciences, Consistency (database systems), Clinical trials · Reporting quality · Inter-individual variation · Quality index · Plant bioactive · Recommendations · Guidelines, 0302 clinical medicine, Clinical trials, Plant bioactive, Quality index, Humans, Quality (business), Data reporting, media_common, Consumption (economics), 030109 nutrition & dietetics, Nutrition and Dietetics, Diet, Vegetarian, Reproducibility of Results, Data Accuracy, Clinical trial, Biological Variation, Population, Research Design, Plants, Edible, Psychology, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

Purpose The quality of the study design and data reporting in human trials dealing with the inter-individual variability in response to the consumption of plant bioactives is, in general, low. There is a lack of recommendations supporting the scientific community on this topic. This study aimed at developing a quality index to assist the assessment of the reporting quality of intervention trials addressing the inter-individual variability in response to plant bioactive consumption. Recommendations for better designing and reporting studies were discussed. Methods The selection of the parameters used for the development of the quality index was carried out in agreement with the scientific community through a survey. Parameters were defined, grouped into categories, and scored for different quality levels. The applicability of the scoring system was tested in terms of consistency and effort, and its validity was assessed by comparison with a simultaneous evaluation by experts’ criteria. Results The “POSITIVe quality index” included 11 reporting criteria grouped into four categories (Statistics, Reporting, Data presentation, and Individual data availability). It was supported by detailed definitions and guidance for their scoring. The quality index score was tested, and the index demonstrated to be valid, reliable, and responsive. Conclusions The evaluation of the reporting quality of studies addressing inter-individual variability in response to plant bioactives highlighted the aspects requiring major improvements. Specific tools and recommendations favoring a complete and transparent reporting on inter-individual variability have been provided to support the scientific community on this field. Electronic supplementary material The online version of this article (10.1007/s00394-019-02069-3) contains supplementary material, which is available to authorized users., Key messages The reporting quality of human studies on inter-individual variation in response to plant bioactives is generally low and should be significantly improved.There is no specific guidance for reporting studies on inter-individual variation in response to plant bioactives.The assessment of reporting quality using a scale approach is considered a valuable tool in assessing compliance with the recommendations in the submission phase or during the reviewing process. It also provides a quantitative measure of the quality of studies to be used in meta-analysis.Eleven reporting criteria were developed and supported by detailed definitions and guidance for their scoring.The POSITIVe quality index was tested and demonstrated to be valid, reliable, and responsive.The use of the quality index and its supporting explanatory material (dictionary) as a guide for researchers, peer-reviewers, and journal editors will foster further complete and transparent reporting of data on inter-individual variability.The criteria used in the quality index can serve as additional guidance to inform the design and conduction of further studies on inter-individual variations in response to plant bioactives.Better reporting is expected to lead to a better understanding of the mechanisms and factors involved and thus better study designs with greater impact on policies and practice. Electronic supplementary material The online version of this article (10.1007/s00394-019-02069-3) contains supplementary material, which is available to authorized users.

Published
2019
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30. Factors influencing the cardiometabolic response to (poly)phenols and phytosterols: a review of the COST Action POSITIVe activities

Author

Antonio González-Sarrías, Eileen R. Gibney, Emilie Combet, Dragan Milenkovic, Tatjana Ruskovska, Arno Greyling, Ana Rodriguez-Mateos, Baujke de Roos, Christine Morand, Francisco A. Tomás-Barberán, UCD School of Agriculture and Food Science, University College Dublin [Dublin] (UCD), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), College of Medical, Veterinary and Life Sciences, University of Glascow, University Goce Delcev (UGD), Unilever Research and Development, Food and Health, Centro de Edafologia y Biologia Aplicada del Segura, Rowett Research Institute, University of Aberdeen, Department of Nutritional Sciences, Mount Sinai Hospital (MSH), King’s College London, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Mount Sinai Hospital [Toronto, Canada] (MSH), King‘s College London, and European Cooperation in Science and Technology (COST) FA1403

Subjects
0301 basic medicine, and promotion of well-being, [SDV]Life Sciences [q-bio], Medicine (miscellaneous), Review, Cardiovascular, Cardiovascular System, Oral and gastrointestinal, law.invention, Metabotype, 0302 clinical medicine, Randomized controlled trial, law, Medicine, Cost action, Data reporting, Cancer, 2. Zero hunger, Nutrition and Dietetics, Diet, Vegetarian, Phytosterol, Phytosterols, Biological Variation, Response, Plants, Cardiometabolic diseases, 3. Good health, Europe, Health, Plants, Edible, Population, Clinical Trials and Supportive Activities, 030209 endocrinology & metabolism, Variation, 03 medical and health sciences, Edible, Vegetarian, Clinical Research, Environmental health, Complementary and Integrative Health, Genetics, Humans, Metabolomics, Obesity, Microbiome, 3.3 Nutrition and chemoprevention, Metabolic and endocrine, Nutrition, 030109 nutrition & dietetics, Nutrition & Dietetics, business.industry, Dietary constituent, Prevention, Polyphenols, Plant, Prevention of disease and conditions, Diet, Clinical trial, Metabolism, Biological Variation, Population, Bioactive, Personalized nutrition, Gene expression, business
Abstract

Purpose Evidence exists regarding the beneficial effects of diets rich in plant-based foods regarding the prevention of cardiometabolic diseases. These plant-based foods are an exclusive and abundant source of a variety of biologically active phytochemicals, including polyphenols, carotenoids, glucosinolates and phytosterols, with known health-promoting effects through a wide range of biological activities, such as improvements in endothelial function, platelet function, blood pressure, blood lipid profile and insulin sensitivity. We know that an individual’s physical/genetic makeup may influence their response to a dietary intervention, and thereby may influence the benefit/risk associated with consumption of a particular dietary constituent. This inter-individual variation in responsiveness has also been described for dietary plant bioactives but has not been explored in depth. To address this issue, the European scientific experts involved in the COST Action POSITIVe systematically analyzed data from published studies to assess the inter-individual variation in selected clinical biomarkers associated with cardiometabolic risk, in response to the consumption of plant-based bioactives (poly)phenols and phytosterols. The present review summarizes the main findings resulting from the meta-analyses already completed. Results Meta-analyses of randomized controlled trials conducted within POSITIVe suggest that age, sex, ethnicity, pathophysiological status and medication may be responsible for the heterogeneity in the biological responsiveness to (poly)phenol and phytosterol consumption and could lead to inconclusive results in some clinical trials aiming to demonstrate the health effects of specific dietary bioactive compounds. However, the contribution of these factors is not yet demonstrated consistently across all polyphenolic groups and cardiometabolic outcomes, partly due to the heterogeneity in trial designs, low granularity of data reporting, variety of food vectors and target populations, suggesting the need to implement more stringent reporting practices in the future studies. Studies investigating the effects of genetic background or gut microbiome on variability were limited and should be considered in future studies. Conclusion Understanding why some bioactive plant compounds work effectively in some individuals but not, or less, in others is crucial for a full consideration of these compounds in future strategies of personalized nutrition for a better prevention of cardiometabolic disease. However, there is also still a need for the development of a substantial evidence-base to develop health strategies, food products or lifestyle solutions that embrace this variability., Key messages A balanced diet, rich in plant-based foods is known for the prevention of obesity, diabetes, and cardiovascular disease risk.(Poly)phenols and phytosterols displayed a range of biological effects of relevance to contribute to the cardiometabolic health benefits of plant foodsHowever, inter-individual variability in response to plant food bioactive consumption exists, and there is a need to understand the causes of this variation.Analysis of published RCTs examining impact of consumption of (poly)phenols and phytosterols on cardiometabolic risk factors demonstrated that a number of factors including age, sex, adiposity and health status could contribute to the effect demonstrated within these studies.Genome and microbiome studies will help identify what may be causing this variation.More studies, specifically designed to investigate individual variation are needed to fully understand the factors responsible for and the impact of this variationOnce fully understood, such variation should be used in directing personalised nutrition advice.

Published
2019
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31. Simulating rewetting events in intermittent rivers and ephemeral streams: a global analysis of leached nutrients and organic matter

Author

Arnaud Foulquier, Michael T. Bogan, Björn Gücker, Roland Corti, Daniel von Schiller, Pablo Rodríguez-Lozano, Fiona Dyer, Vladimir Pešić, Stefan Lorenz, Klement Tockner, Jonathan C. Marshall, Lluís Gómez-Gener, Ana Savić, Thibault Datry, Dominik Zak, Rubén del Campo, Marcos Moleón, Clara Mendoza-Lera, Elisabeth I. Meyer, Chelsea J. Little, Simone Guareschi, Ross Vander Vorste, Richardo Figueroa, Florian Altermatt, Michael Danger, Oleksandra Shumilova, Musa C. Mlambo, Rosa Gómez Cerezo, Annamaria Zoppini, Joanna Blessing, Kate S. Boersma, Petr Paril, Núria Bonada, Alisha L. Steward, Christiane Zarfl, Amina Taleb, Manuel A. S. Graça, Juan F. Blanco-Libreros, Peter M. Negus, Isabel Pardo, Iola G. Boëchat, Ryan M. Burrows, Stephanie M. Carlson, Angus R. McIntosh, Mark O. Gessner, Andy Banegas-Medina, Simone D. Langhans, María Isabel Arce, Kate Brintrup, Rachel Stubbington, Pierre Gnohossou, Biel Obrador, Athina Papatheodoulou, Erin E. Beller, Nick Bond, Shai Arnon, Robert J. Rolls, Brian Four, Catherine M. Febria, Sophie Cauvy-Fraunié, Bianca de Freitas Terra, Catherine Leigh, Emile Faye, Andreas Bruder, Daniel C. Allan, Jason L. Hwan, Núria Cid, Skhumbuzo Kubheka, Damien Banas, Nathan J. Waltham, M. M. Sánchez-Montoya, Arturo Elosegi, Marko Miliša, Dev K. Niyogi, Anna Maria De Girolamo, Tommaso Cancellario, Melanie L. Blanchette, European Commission, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Freie Universität Berlin, University of Trento, Universität Rostock, Aarhus University, Institut National de Recherche en Sciences et Technologies pour l'Environnement et l'Agriculture (IRSTEA), University of the Basque Country (University of the Basque Country), Laboratoire d'Ecologie Alpine (LECA), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Joseph Fourier - Grenoble 1 (UJF)-Université Grenoble Alpes (UGA), Centre National de la Recherche Scientifique (CNRS), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), University of Barcelona, Austrian Science Fund (FWF), University of Oklahoma (OU), University of Zurich, Centro de Edafologia y Biologia Aplicada del Segura, Ben-Gurion University of the Negev (BGU), Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Universidad de Concepción, University of California [Berkeley], University of California, Edith Cowan University, University of Antioquia, Queensland Government, Universidade Federal de São João del-Rei (UFSJ), University of California [San Diego] (UC San Diego), University of Arizona, Universitat Autònoma de Barcelona [Barcelona] (UAB), La Trobe University, University of Applied Sciences and Arts Switzerland, Griffith University [Brisbane], University of Navarra, Laboratoire Interdisciplinaire des Environnements Continentaux (LIEC), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Université de Lorraine (UL), Universidade Estadual Vale do Acarau, National Council of Research, Water Research Institute, Universidad de Murcia, University of Canberra, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), University of Canterbury, University of Windsor, Département Ecologie des Forêts, Prairies et milieux Aquatiques (DEPT EFPA), Institut National de la Recherche Agronomique (INRA), Berlin Institute of Technology, Université de Parakou, Umea University, University of Coimbra, Ezemvelo KZN Wildlife, University of Otago [Dunedin, Nouvelle-Zélande], Basque Centre for Climate Change (BC3), Queensland University of Technology, Swiss Federal Institute of Aquatic Science and Technology (EAWAG), Julius Kühn-Institut (JKI), Brandenburg University of Technology, University of Münster, University of Zagreb, Rhodes University, Universidad de Granada (UGR), Missouri University of Science and Technology (Missouri S&T), University of Missouri System, Terra Cypria - Cyprus Conservation Foundation, Universidate de Vigo, Masaryk University, University of Montenegro (UCG), University of New England (UNE), University of Niš, Nottingham Trent University, Université de Tlemcen, James Cook University (JCU), University of Tübingen, Aarhus University [Aarhus], Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Universitat Autònoma de Barcelona (UAB), Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Terre et Environnement de Lorraine (OTELo), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), University of Canterbury [Christchurch], University of Windsor [Ca], Université de Parakou (UP), Department of Ecology and Environmental Science [Umeå], Umeå University, Swiss Federal Insitute of Aquatic Science and Technology [Dübendorf] (EAWAG), Rhodes University, Grahamstown, Universidade de Vigo, and Masaryk University [Brno] (MUNI)

Subjects
0106 biological sciences, Geologic Sediments, sédiment, 010504 meteorology & atmospheric sciences, Climate, rehumectation, 01 natural sciences, Substance nutritive, Klimatforskning, chemistry.chemical_compound, zone humide temporaire, Nutrient, Nitrate, matière organique dissoute, Dissolved organic carbon, Canvi climàtic, Primary Research Article, Organic Chemicals, General Environmental Science, chemistry.chemical_classification, Global and Planetary Change, leaf litter, cycle des nutriments, Ecology, zone climatique, Litière végétale, Sediments fluvials, sediments, Lessivage du sol, 6. Clean water, Lixiviació, biofilms, leaching, rewetting, temporary rivers, climatic region, climate change, Environmental chemistry, Leaching (pedology), Biogeochemical cycle, Climate Research, P40 - Météorologie et climatologie, [SDE.MCG]Environmental Sciences/Global Changes, Cours d'eau, Climate change, Biological Availability, 010603 evolutionary biology, River sediments, Sécheresse, biodisponibilité, Rivers, Environmental Chemistry, Organic matter, litière du sol, Matière organique, P10 - Ressources en eau et leur gestion, variation géographique, 0105 earth and related environmental sciences, Changement climatique, Nitrates, entraînement par lessivage, P35 - Fertilité du sol, Nutrients, 15. Life on land, Primary Research Articles, Arid, Climatic change, Plant Leaves, chemistry, 13. Climate action, Environmental science, bioavailability
Abstract

Climate change and human pressures are changing the global distribution and the extent of intermittent rivers and ephemeral streams (IRES), which comprise half of the global river network area. IRES are characterized by periods of flow cessation, during which channel substrates accumulate and undergo physico‐chemical changes (preconditioning), and periods of flow resumption, when these substrates are rewetted and release pulses of dissolved nutrients and organic matter (OM). However, there are no estimates of the amounts and quality of leached substances, nor is there information on the underlying environmental constraints operating at the global scale. We experimentally simulated, under standard laboratory conditions, rewetting of leaves, riverbed sediments, and epilithic biofilms collected during the dry phase across 205 IRES from five major climate zones. We determined the amounts and qualitative characteristics of the leached nutrients and OM, and estimated their areal fluxes from riverbeds. In addition, we evaluated the variance in leachate characteristics in relation to selected environmental variables and substrate characteristics. We found that sediments, due to their large quantities within riverbeds, contribute most to the overall flux of dissolved substances during rewetting events (56%–98%), and that flux rates distinctly differ among climate zones. Dissolved organic carbon, phenolics, and nitrate contributed most to the areal fluxes. The largest amounts of leached substances were found in the continental climate zone, coinciding with the lowest potential bioavailability of the leached OM. The opposite pattern was found in the arid zone. Environmental variables expected to be modified under climate change (i.e. potential evapotranspiration, aridity, dry period duration, land use) were correlated with the amount of leached substances, with the strongest relationship found for sediments. These results show that the role of IRES should be accounted for in global biogeochemical cycles, especially because prevalence of IRES will increase due to increasing severity of drying events., In this study we experimentally simulated under laboratory conditions rewetting of leaves, riverbed sediments, and epilithic biofilms collected during the dry phase from intermittent rivers and ephemeral streams covering global spatial scale. We determined the amounts and quality of the leached nutrients and dissolved organic matter, assessed their inter‐substrate and cross‐climate differences, and estimated areal fluxes from 1 m2 of riverbeds. In addition, we evaluated the variance in leachate characteristics related to selected environmental variables and substrate characteristics.

Published
2019
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32. Future prospects for dissecting inter-individual variability in the absorption, distribution and elimination of plant bioactives of relevance for cardiometabolic endpoints

Author

Baukje de Roos, Francisco A. Tomás-Barberán, Tom Van de Wiele, Frederiek-Maarten Kerckhof, Claudine Manach, Rasha Noureldin M. Saleh, Christine Morand, Anne Marie Minihane, Rikard Landberg, Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Center for Microbial Ecology and Technology (CMET), Gent University, Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, The Rowett Research Institute, University of Aberdeen, Centro de Edafología y Biología Aplicada del Segura (CEBAS-CSIC), Chalmers University of Technology [Gothenburg, Sweden], Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Universiteit Gent = Ghent University [Belgium] (UGENT), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universiteit Gent = Ghent University (UGENT), University of East Anglia [Norwich] (UEA), and Landberg, R.

Subjects
0301 basic medicine, Agriculture and Food Sciences, Cardiometabolic, Future studies, BIOAVAILABILITY, Phytochemicals, Medicine (miscellaneous), Genomics, Computational biology, Review, Biology, Cardiovascular System, Inter-individual variation, 03 medical and health sciences, Metabolomics, Personalized nutrition, Plant bioactive compounds, Individual data, Genetic variation, CYP1A2 GENOTYPE, Medicine and Health Sciences, Food and Nutrition, Humans, Cost action, Microbiome, ADME, 2. Zero hunger, RISK, 030109 nutrition & dietetics, Nutrition and Dietetics, Diet, Vegetarian, CONSUMPTION, ASSOCIATION, 3. Good health, 030104 developmental biology, Biological Variation, Population, DEMETHYLASE, COMT GENOTYPE, Alimentation et Nutrition, Plants, Edible, VASCULAR FUNCTION, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, FLAVANONES, O-METHYLTRANSFERASE GENOTYPE
Abstract

Purpose The health-promoting potential of food-derived plant bioactive compounds is evident but not always consistent across studies. Large inter-individual variability may originate from differences in digestion, absorption, distribution, metabolism and excretion (ADME). ADME can be modulated by age, sex, dietary habits, microbiome composition, genetic variation, drug exposure and many other factors. Within the recent COST Action POSITIVe, large-scale literature surveys were undertaken to identify the reasons and extent of inter-individual variability in ADME of selected plant bioactive compounds of importance to cardiometabolic health. The aim of the present review is to summarize the findings and suggest a framework for future studies designed to investigate the etiology of inter-individual variability in plant bioactive ADME and bioefficacy. Results Few studies have reported individual data on the ADME of bioactive compounds and on determinants such as age, diet, lifestyle, health status and medication, thereby limiting a mechanistic understanding of the main drivers of variation in ADME processes observed across individuals. Metabolomics represent crucial techniques to decipher inter-individual variability and to stratify individuals according to metabotypes reflecting the intrinsic capacity to absorb and metabolize bioactive compounds. Conclusion A methodological framework was developed to decipher how the contribution from genetic variants or microbiome variants to ADME of bioactive compounds can be predicted. Future study design should include (1) a larger number of study participants, (2) individual and full profiling of all possible determinants of internal exposure, (3) the presentation of individual ADME data and (4) incorporation of omics platforms, such as genomics, microbiomics and metabolomics in ADME and efficacy studies., Key messages Human intervention studies are typically too small and do not report data from individuals to allow investigations of relevant determinants of inter-individual variability in ADME and bioefficacy.For some plant food bioactive compounds (isoflavones and ellagitannins), particular metabolites are produced only in a subset of the population, i.e., among individuals with a specific metabotype.Microbiota is an important determinant of the ADME of many bioactive compounds but microbial gene annotation is often lacking and interference with background diet and temporal variability is high: microbial metabolism capacity is, therefore, difficult to predict.Genetic variability is considered an important determinant of the ADME of some bioactive compounds, but there is a large gap in knowledge for many families of plant bioactive compounds regarding biotransformation enzymes and transport proteins.Information on other determinants such as age, sex, and diet is too incomplete to make firm conclusions about their impact on the inter-individual variability for most compounds investigatedMetabotyping individuals appears as essential to increase our understanding and improve prediction of ADME and health effects of plant bioactive compounds. Yet successful stratification examples are scarce and if available (e.g., urolithins), validation studies in larger cohorts are still required.

Published
2019
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33. Statement of Foliar Fertilization Impact on Yield, Composition, and Oxidative Biomarkers in Rice

Author

Raúl Domínguez-Perles, Thierry Durand, Jean-Marie Galano, M. Pinciroli, Angel Gil-Izquierdo, Federico Ferreres, Valérie Bultel-Poncé, Ángel Abellán, Universidad Nacional de la Plata [Argentine] (UNLP), Centro de Edafologia y Biologia, Aplicada del Segura, Spanish National Research Council (CSIC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, Oryza sativa, Oxidative phosphorylation, Biology, 01 natural sciences, Human fertilization, genotypes, Yield (wine), phytofurans, Foliar fertilization, protein grain, Dry matter, Ciencias Agrarias, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Fertilizers, Furans, Plant Proteins, 2. Zero hunger, Abiotic stress, 010401 analytical chemistry, foliar fertilization, food and beverages, Oryza, General Chemistry, phytoprostanes, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, 0104 chemical sciences, Plant Leaves, Horticulture, Oxidative Stress, Composition (visual arts), General Agricultural and Biological Sciences, Biomarkers, 010606 plant biology & botany
Abstract

In rice crops, fertilization is a naturalized practice, although inefficient, that could be improved by applying foliar fertilization. Phytoprostanes (PhytoPs) and phytofurans (PhytoFs) are products of α-linolenic acid peroxidation, useful as biomarkers of oxidative degradation in higher plants. The objective was to determine the effect of the foliar fertilization on the concentration of PhytoPs and PhytoFs and its relationships with modifications of yield and quality of rice productions. It was described that the concentration of biomarkers of stress decreased with the application of foliar fertilization, being the response significantly different depending the genotypes and compound monitored. Moreover, fertilization did not modify significantly the parameters of yield (961.2 g m−2), 1000 whole-grain (21.2 g), and protein content (10.7% dry matter). Therefore, this is the first work that describes the effect of fertilization on PhytoPs and PhytoFs in rice genotypes and reinforces the capacity of these compounds as biomarkers to monitor specific abiotic stress, in this case, represented by nutritional stress., Facultad de Ciencias Agrarias y Forestales

Published
2019
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34. Interindividual Variability in Absorption, Distribution, Metabolism, and Excretion of Food Phytochemicals Should Be Reported

Author

Francisco A. Tomás-Barberán, Christine Morand, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centro de Edafologia y Biologia Aplicada del Segura, Projects 201870E014 (CSIC, Spain and Fundaction Seneca (19900/GERM/15), Unité de Nutrition Humaine (UNH), and Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

Subjects
0303 health sciences, 030309 nutrition & dietetics, Chemistry, Phytochemicals, digestive, oral, and skin physiology, 030209 endocrinology & metabolism, General Chemistry, Metabolism, Gastrointestinal Microbiome, Excretion, 03 medical and health sciences, 0302 clinical medicine, Intestinal Absorption, Environmental chemistry, Humans, Distribution (pharmacology), General Agricultural and Biological Sciences, Absorption (electromagnetic radiation), [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Food Analysis
Abstract

Interindividual Variability in Absorption, Distribution, Metabolism, and Excretion of Food Phytochemicals Should Be Reported

Published
2019
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35. Spatial variability of the relationships of runoff and sediment yield with weather types throughout the Mediterranean basin

Author

G. Desir, José María Senciales-González, Patricio Cid, Álvaro Gómez-Gutiérrez, Luis Merino-Martín, Carla Ferreira, Tíscar Espigares, Miguel A. Campo-Bescós, Albert Solé-Benet, Asunción Romero-Díaz, Julián Martínez-Fernández, Damien Raclot, Damià Vericat, Agata Novara, María Martínez-Mena, C. Le Bouteiller, Encarnación V. Taguas, Francesca Todisco, Antonio Canatário-Duarte, Luciano Mateos, Francesc Gallart, José Andrés López-Tarazón, Susana Bernal, Emmanouil A. Varouchakis, Y. Le Bissonnais, Mariano Moreno-de las Heras, Noemí Lana-Renault, A. Zabaleta, Dhais Peña-Angulo, M. Mercedes Taboada-Castro, Lea Wittenberg, Ramon J. Batalla, Vito Ferro, Susanne Schnabel, Xavier Úbeda, Victor Castillo, Matija Zorn, José Carlos González-Hidalgo, Ramón Bienes, Juan Albaladejo, M.T. Taboada-Castro, Feliciana Licciardello, C. Marín, V. Simonneaux, Óscar González-Pelayo, George P. Karatzas, H. Barhi, Roberto Lázaro, E. Roose, Jesús Rodrigo-Comino, Joan Estrany, Julián Campo, Elvira Díaz-Pereira, José Luis Rubio, Sébastien Klotz, Artemio Cerdà, Javier Casalí, Vicente Andreu, Helena Gómez-Macpherson, Nicolle Mathys, Yolanda Cantón, Estela Nadal-Romero, Teodoro Lasanta, Nicola Cortesi, Orestis Kairis, Rafael Giménez, Maria Jose Marques, María Fernández-Raga, A. Cheggour, José Damián Ruiz-Sinoga, Vincenzo Pampalone, José A. Gómez, Vincenzo Bagarello, Paloma Hueso-Gonzalez, José M. Nicolau, Ana Lucía, N. Moustakas, Costas Kosmas, M. L. Rodríguez-Blanco, Jérôme Latron, E. Gimeno, Juan F. Martínez-Murillo, Govern de les Illes Balears, Generalitat de Catalunya, Fundação para a Ciência e a Tecnologia (Portugal), Ministerio de Educación, Cultura y Deporte (España), Ministerio de Economía y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Universidad de Lleida, Ministerio de Educación y Ciencia (España), Instituto Universitario de Ciencias Ambientales (IUCA), Departamento de Geografía, University of Zaragoza, Instituto Pirenaico de Ecología (IPE), Soil and Water Conservation Research Group, Centro de Edafologia y Biologia Aplicada del Segura, Desertification Research Centre, Department of Environmental Quality and Soils, CIDE-CSIC, Department of Agricultural, Food and Forest Sciences, Università degli studi di Palermo - University of Palermo, Institut National de Recherche en Génie Rural, Eaux et Forêts de Tunisie (INRGREF), Catalan Institute for Water Research (ICRA), Faculty of Forest Sciences and Natural Resources, Universidad Austral de Chile, RIUS, Fluvial Dynamics Research Group, University of Lleida (UL), Integrative Freshwater Ecology Group, Centre d’Estudis Avançats de Blanes, Departamento Investigación Aplicada y Extensión Agraria, Instituto Madrileño de Investigación y Desarrollo Rural, Agrario y Alimentario (IMIDRA), ISFOOD Institute, Department of Projects and Rural Engineering, Universidad Pública de Navarra, School of Agriculture, Food and Rural Development, Center for GeoBioSciences, GeoTechnologies and GeoEngineering (GEOBIOTEC), Universidade da Beira Interior, Department of Agronomy (Soil Science Area), University of Almeria, Department of Geography, Soil Erosion and Degradation Research Group, Université de Valence, Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Maize Genetics and Genomics Lab, CINVESTAV, Department of Earth Sciences, Centro Nacional de Supercomputación, Departamento de Ciencias de la Tierra, Departamento de Ciencias de la Vida, Unidad de Ecología, Universidad de Alcalá de Henares (UAH), Department of Geography, Mediterranean Ecogeomorphological and Hydrological Connectivity Research Team (MEDhyCON), University of the Balearic Islands (UIB), Department of Applied Chemistry and Physics, University of Leon, College of Agriculture, Research Centre for Natural Resources, Environment and Society (CERNAS), Instituto Politécnico de Coimbra, Department of Earth and Marine Sciences [Palermo], Institute of Environmental Assessment and Water Research (IDAEA), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Instituto de Agricultura Sostenible (IAS), Instituto de Agricultura, INTERRA Research Institute, University of Extremadura, Department of Environment and Planning, Earth Surface Processes Team (ESP) Centre for Environmental and Marine Studies (CESAM), University of Aveiro, Department of Natural Resources Management and Agricultural Engineering, Agricultural University of Athens, School of Environmental Engineering, Technical University of Crete, Erosion torrentielle neige et avalanches (UR ETGR (ETNA)), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Université Grenoble Alpes (COMUE) (UGA), Area of Physical Geography, DCH, Universidad de la Rioja, Experimental Station of Arid Zones (EEZA), Consejo Superior de Investigaciones Científicas, Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut de Recherche pour le Développement (IRD [ Madagascar])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Department of Agriculture, Food and Environment, Department of Geography, Mediterranean Ecogeomorphological and Hydrological Connectivity Research Team (MEDhyCON) Hydrol Connect Res, Dept Geog, Palma De Mallorca 07122, Spain, Institute of Earth and Environmental Science [Potsdam], University of Potsdam, Faculty of Sciences, Center for Applied Geosciences, Eberhard Karls University Tübingen, Instituto Hispano Luso de Investigaciones Agrarias, Universidad de Salamanca, Botanique et Modélisation de l'Architecture des Plantes et des Végétations (UMR AMAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut d'Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS), Université Paul Valéry (Montpellier 3), Université de Montpellier (UM), École pratique des hautes études (EPHE), Institut de Recherche pour le Développement (IRD [Bolivie]), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université Paul-Valéry - Montpellier 3 (UM3), Instituto Universitario de Ciencias Ambientales, Escuela Politécnica Superior, Faculty of Sciences, Centre for Advanced Scientific Research (CICA), University of A Coruña (UDC), Physical Geography, Trier University, Departamento de Geografía, Universidad de Cantabria [Santander], UMR Eco&Sols, Centre d'études spatiales de la biosphère (CESBIO), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, ETSIAM Campus Rabanales, Universidad de Cordoba, Department of Agriculture-Food and Environmental Sciences, Agricultural and Biosystems Engineering Research Unit, Università degli Studi di Perugia (UNIPG), Departamento de Geografía, Grup de Recerca Ambiental Mediterrània, University of Barcelona, Forest Science and Technology Centre of Catalonia, Department of Geography and Environmental Studies, University of Nairobi (UoN), Science and Technology Faculty, Hydro-Environmental Processes Research Group, University of the Basque Country (University of the Basque Country), Geographical Institute, Scientific Research Center of the Slovenian Academy of Sciences and Arts (ZRC SAZU), MINECO-FEDER [CGL2014-52135-C3-3-R, CGL2014-59946-R, CGL2015-65569-R, CGL2015-64284-C2-2-R, PCIN-2017-061/AEI], Spanish Ministry of Economy and Competitiveness, MEC [RYC-2013-14371, RYC-2010-06264], Spanish Ministry of Education, Culture and Sports, Portuguese Science and Technology Foundation [SFRH/BPD/120093/2016], Juan de la Cierva postdoctoral contract from the MEC [IJCI-2015-26463], Vicenc Mut postdoctoral fellowship from the Autonomous Balearic Government [CAIB PD/038/2016], Secretariat for Universities and Research of the Department of the Economy and Knowledge of the Autonomous Government of Catalonia [2014 SGR 645], CERCA Programme, COST action CONNECTEUR [ES1306], University of Zaragoza - Universidad de Zaragoza [Zaragoza], Instituto Pirenaico de Ecologìa = Pyrenean Institute of Ecology [Zaragoza] (IPE - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut National de Recherche en Génie Rural Eaux et Forêts (INRGREF), Ecole Nationale du Génie Rural, des Eaux et des Forêts (ENGREF)-Institution de la Recherche et de l'Enseignement Supérieur Agricoles [Tunis] (IRESA), Instituto Catalán de Investigación del Agua - ICRA (SPAIN) (ICRA), Universidad Pública de Navarra [Espagne] = Public University of Navarra (UPNA), Universidade de Aveiro, Universitat de València (UV), Université Cadi Ayyad [Marrakech] (UCA), Barcelona Supercomputing Center - Centro Nacional de Supercomputacion (BSC - CNS), Instituto de Agricultura Sostenible - Institute for Sustainable Agriculture (IAS CSIC), Universidad de Extremadura - University of Extremadura (UEX), Universidad de Málaga [Málaga] = University of Málaga [Málaga], Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), University of Potsdam = Universität Potsdam, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Universidad Autónoma de Madrid (UAM), Université Paul-Valéry - Montpellier 3 (UPVM), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL), Université Paul-Valéry - Montpellier 3 (UPVM)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes (UMR Eco&Sols), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Toulouse (UT), Universidad de Córdoba = University of Córdoba [Córdoba], Università degli Studi di Perugia = University of Perugia (UNIPG), Centre de Ciència i Tecnologia Forestal de Catalunya (CTFC), Pena-Angulo D., Nadal-Romero E., Gonzalez-Hidalgo J.C., Albaladejo J., Andreu V., Bagarello V., Barhi H., Batalla R.J., Bernal S., Bienes R., Campo J., Campo-Bescos M.A., Canatario-Duarte A., Canton Y., Casali J., Castillo V., Cerda A., Cheggour A., Cid P., Cortesi N., Desir G., Diaz-Pereira E., Espigares T., Estrany J., Fernandez-Raga M., Ferreira C.S.S., Ferro V., Gallart F., Gimenez R., Gimeno E., Gomez J.A., Gomez-Gutierrez A., Gomez-Macpherson H., Gonzalez-Pelayo O., Hueso-Gonzalez P., Kairis O., Karatzas G.P., Klotz S., Kosmas C., Lana-Renault N., Lasanta T., Latron J., Lazaro R., Le Bissonnais Y., Le Bouteiller C., Licciardello F., Lopez-Tarazon J.A., Lucia A., Marin C., Marques M.J., Martinez-Fernandez J., Martinez-Mena M., Martinez-Murillo J.F., Mateos L., Mathys N., Merino-Martin L., Moreno-de las Heras M., Moustakas N., Nicolau J.M., Novara A., Pampalone V., Raclot D., Rodriguez-Blanco M.L., Rodrigo-Comino J., Romero-Diaz A., Roose E., Rubio J.L., Ruiz-Sinoga J.D., Schnabel S., Senciales-Gonzalez J.M., Simonneaux V., Sole-Benet A., Taguas E.V., Taboada-Castro M.M., Taboada-Castro M.T., Todisco F., Ubeda X., Varouchakis E.A., Vericat D., Wittenberg L., Zabaleta A., Zorn M., Instituto Pirenaico de Ecologia (IPE), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Universidad Autonoma de Madrid (UAM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), and Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)

Subjects
010504 meteorology & atmospheric sciences, Runoff, Erosion, Mediterranean basin, Sediment yield, Synoptic weather types, 0207 environmental engineering, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, 02 engineering and technology, 01 natural sciences, Mediterranean Basin, Hydrology (agriculture), Erosão, Produção de sedimentos, Escoamento, Bacia Mediterrânica, Soil retrogression and degradation, ddc:550, 020701 environmental engineering, 0105 earth and related environmental sciences, Water Science and Technology, Hydrology, Sediment, Institut für Umweltwissenschaften und Geographie, 15. Life on land, 6. Clean water, 13. Climate action, Environmental science, Spatial variability, Soil conservation, Surface runoff
Abstract

Este artículo contiene 16 páginas, 6 figuras, 2 tablas., Soil degradation by water is a serious environmental problem worldwide, with specific climatic factors being the major causes. We investigated the relationships between synoptic atmospheric patterns (i.e. weather types, WTs) and runoff, erosion and sediment yield throughout the Mediterranean basin by analyzing a large database of natural rainfall events at 68 research sites in 9 countries. Principal Component Analysis (PCA) was used to identify spatial relationships of the different WTs including three hydro-sedimentary variables: rainfall, runoff, and sediment yield (SY, used to refer to both soil erosion measured at plot scale and sediment yield registered at catchment scale). The results indicated 4 spatial classes of rainfall and runoff: (a) northern sites dependent on North (N) and North West (NW) flows; (b) eastern sites dependent on E and NE flows; (c) southern sites dependent on S and SE flows; and, finally, (d) western sites dependent on W and SW flows. Conversely, three spatial classes are identified for SY characterized by: (a) N and NE flows in northern sites (b) E flows in eastern sites, and (c) Wand SW flows in western sites. Most of the rainfall, runoff and SY occurred during a small number of daily events, and just a few WTs accounted for large percentages of the total. Our results confirm that characterization by WT improves understanding of the general conditions under which runoff and SY occur, and provides useful information for understanding the spatial variability of runoff, and SY throughout the Mediterranean basin. The approach used here could be useful to aid of the design of regional water management and soil conservation measures., This research was supported by projects funded by the MINECOFEDER: CGL2014-52135-C3-3-R, CGL2014-59946-R, CGL2015-65569- R, CGL2015-64284-C2-2-R, and PCIN-2017-061/AEI. When this manuscript was first submitted Estela Nadal-Romero and Damià Vericat received a “Ramón y Cajal” postdoctoral contract (RYC-2013-14371 and RYC‐2010‐06264, Spanish Ministry of Economy and Competitiveness, MEC). Damià Vericat is now a Serra Húnter Fellow at the University of Lleida. María Fernández-Raga received a “José Castillejo” postdoctoral grant (Spanish Ministry of Education, Culture and Sports). Carla Ferreira was supported by a post-doctoral research grant from the Portuguese Science and Technology Foundation (SFRH/ BPD/120093/2016). Mariano Moreno-de las Heras received a Juan de la Cierva postdoctoral contract (IJCI-2015-26463) from the MEC. José Andrés López-Tarazón received a Vicenç Mut postdoctoral fellowship from the Autonomous Balearic Government (CAIB PD/038/2016). José Andrés López-Tarazón and Ramon Batalla also acknowledge the Secretariat for Universities and Research of the Department of the Economy and Knowledge of the Autonomous Government of Catalonia for supporting the Consolidated Research Group 2014 SGR 645 (RIUSFluvial Dynamics Research Group), and the CERCA Programme. This paper has benefited from the Lab and Field Data Pool created within the framework of the COST action CONNECTEUR (ES1306).

Published
2019
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36. Bioactive plant oxylipins-based lipidomics in eighty worldwide commercial dark chocolates: Effect of cocoa and fatty acid composition on their dietary burden

Author

Ángel A. Carbonell-Barrachina, Claudio Jiménez-Cartagena, Marina Cano-Lamadrid, Angel Gil-Izquierdo, Thierry Durand, Julián Londoño-Londoño, Alexandre Guy, Raúl Domínguez-Perles, Federico Ferreres, Jacinta Collado-González, Jean-Marie Galano, Daniel E. León-Perez, Sonia Medina, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Instituto de Ciencia y Tecnología Alimentaria (INTAL), Universidad Miguel Hernández [Elche] (UMH), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Corporacion Universitaria Lasallista, and Universidad Católica San Antonio de Murcia (UCAM)

Subjects
2. Zero hunger, chemistry.chemical_classification, biology, Chemistry, Theobroma, [SDV]Life Sciences [q-bio], 010401 analytical chemistry, food and beverages, Fatty acid, 02 engineering and technology, Dark chocolate, 021001 nanoscience & nanotechnology, biology.organism_classification, 01 natural sciences, food.food, 0104 chemical sciences, Analytical Chemistry, food, Fruits and vegetables, Lipidomics, Fatty acid composition, Food science, 0210 nano-technology, Spectroscopy
Abstract

International audience; Phytoprostanes (PhytoPs) and phytofurans (PhytoFs) are plant oxylipins (isoprostane-prostaglandin-like compounds) formed by the free radical-catalyzed oxidation of α-linolenic acid (ALA, C18:3, n-3). These oxylipins have been previously described in an array of plant-based foods with similar concentrations as phenolics in some fruits and vegetables, but their occurrence in dark chocolate has not been addressed so far, neither their content nor the influence of cocoa percent and fatty acid composition on the generation of PhytoPs and PhytoFs, to establish new assays in order to boost the dietary burden of these new bioactive compounds, provided by natural plant-based foods intake. In this regard, 80 dark chocolate samples with cocoa (Theobroma cacao L.) content of up to 100% were assessed on their PhytoP and PhytoF profile. These target analytes were isolated using a dispersive liquid–liquid extraction followed by a solid-phase clean-up of the extracts, and quantified using a UHPLC coupled to a triple quadrupole-MS/MS detection system. The content of PhytoPs and PhytoFs in the array of chocolates analyzed oscillated from 2.45 to 1192.43 ng/g fw and from 144.57 to 840.19 ng/g fw, respectively. The profile of these metabolites was studied in conjunction with the fatty acid methyl esters (FAMEs) content and the percentage of cocoa; however, no relationship between PhytoPs and PhytoFs and FAMEs content nor the cocoa percentage was observed. The assessment of dark chocolates on the content of PhytoPs and PhytoFs is of great importance as there is increasing scientific evidence on their immunomodulatory and inflammatory activity, as well as their role as preventive agents against oxidative stress that could confer this food an additional interest to consumers.

Published
2020
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37. Impact of Salicylic Acid Content and Growing Environment on Phytoprostane and Phytofuran (Stress Biomarkers) in Oryza sativa L

Author

Thierry Durand, M. Pinciroli, Jean-Marie Galano, Camille Oger, Angel Gil-Izquierdo, M. Garbi, Federico Ferreres, Raúl Domínguez-Perles, Ángel Abellán, Universidad Nacional de la Plata [Argentine] (UNLP), Centro de Edafologia y Biologia, Aplicada del Segura, Spanish National Research Council (CSIC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, 0301 basic medicine, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, Electrospray ionization, Biología, agronomical practices, Environment, medicine.disease_cause, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Plant Growth Regulators, Tandem Mass Spectrometry, medicine, oxidative stress, Oxylipins, Food science, Ciencias Agrarias, Mode of action, Chromatography, High Pressure Liquid, 2. Zero hunger, Oryza sativa, biology, Abiotic stress, rice, biomarkers, Oryza, General Chemistry, biology.organism_classification, air temperature, 030104 developmental biology, Mechanism of action, chemistry, Plant hormone, medicine.symptom, Salicylic Acid, General Agricultural and Biological Sciences, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Salicylic acid, Oxidative stress, 010606 plant biology & botany
Abstract

Phytoprostanes (PhytoPs) and phytofurans (PhytoFs) are oxylipins synthesized by nonenzymatic peroxidation of α-linolenic acid. These compounds are biomarkers of oxidative degradation in plant foods. In this research, the effect of environment and supplementation with salicylic acid (SA) on PhytoPs and PhytoFs was monitored by ultra-high-performance liquid chromatography coupled to electrospray ionization and triple quadrupole mass spectrometry (UHPLC-ESI-QqQ-MS/MS) on seven rice genotypes from Oryza sativa L. subsp. japonica. The plastic cover environment and spray application with 1 and 15 mM SA produced a reduction in the concentration of most of these newly established stress biomarkers [9-F1t-PhytoP, ent-16-F1t-PhytoP, ent-16- epi-16-F1t-PhytoP, 9-D1t-PhytoP, 9- epi-9-D1t-PhytoP, 16-B1-PhytoP, 9-L1-PhytoP, ent-16( RS)-9- epi-ST-Δ14-10-PhytoF, ent-9( RS)-12- epi-ST-Δ10-13-PhytoF, and ent-16( RS)-13- epi-ST-Δ14-9-PhytoF] by 60.7% on average. The modification observed in the level of PhytoPs and PhytoFs differed according to the specific oxylipins and genotype, demonstrating a close linkage between genetic features and resistance to abiotic stress, to some extent mediated by the sensitivity of plants to the plant hormone SA that participates in the physiological response of higher plants to stress. Thus, in plants exposed to stressing factors, SA contribute to modulating the redox balance, minimizing the oxidation of fatty acids and thus the syntheis of oxylipins. These results indicated that SA could be a promising tool for managing the thermotolerance of rice crop. However, it remains necessary to study the mechanism of action of PhytoPs and PhytoFs in biochemical processes related to the defense of plants and define their role as stress biomarkers through a nonenzymatic pathway., Facultad de Ciencias Agrarias y Forestales

Published
2018
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38. A systematic review and meta-analysis of randomized controlled trials exploring the role of inter-individual variability on the effect of flavanols on insulin and HOMA-IR

Author

Paula Pinto, Paul A. Kroon, Ana Rodriguez-Mateos, N. Alshammari, Emilie Combet, G. Jiang, S.A. Palma-Duran, Mar Garcia-Aloy, Eileen R. Gibney, A. Katsaltou, Christine Morand, Mt. García-Conesa, Antonio González-Sarrías, A. Konić Ristić, University of Glasgow, Centro de Edafologia y Biologia Aplicada del Segura, Insituto Politécnico de Santarém, Universitat de Barcelona, University College Dublin [Dublin] (UCD), Quadram Institute, University of Belgrade [Belgrade], University of Thessaly, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), King‘s College London, Biotechnology and Biological Sciences Research Council (BBSRC), Unité de Nutrition Humaine (UNH), and Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

Subjects
Oncology, 0303 health sciences, medicine.medical_specialty, Nutrition and Dietetics, 030309 nutrition & dietetics, business.industry, Insulin, medicine.medical_treatment, Medicine (miscellaneous), 030209 endocrinology & metabolism, 3. Good health, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Meta-analysis, Alimentation et Nutrition, medicine, Food and Nutrition, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

A systematic review and meta-analysis of randomized controlled trials exploring the role of inter-individual variability on the effect of flavanols on insulin and HOMA-IR. 2018 Spring Conference on Nutrient-Nutrient Interaction

Published
2018
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39. Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Author

Pedro Mena, Christos Kontogiorgis, Ana Rodriguez-Mateos, Eileen R. Gibney, Juan Carlos Espín, Christine Morand, Sonia de Pascual-Teresa, Geoffrey Istas, Mar Garcia-Aloy, Karen Chambers, Antonio González-Sarrías, Emilie Combet, Paul A. Kroon, María Teresa García-Conesa, Dilip K. Rai, Cristina Andres-Lacueva, Wendy J Hollands, Paula Pinto, Alekxandra Konic Ristic, Centro de Edafologia y Biologia Aplicada del Segura, Quadram Institute Bioscience, College of Medical Veterinary & Life Sciences, University of Glasgow, Department of Food Technology, Biotechnology and Nutrition, Escola Superior Agraria (ESA), Insituto Politécnico de Santarém, Molecular Nutrition and Health Laboratory, Instituto de Technologia Quimica e Biologica, Biomarkers and Nutritional & Food Metabolomics, Faculty of Pharmacy and Food Sciences, University of Barcelona, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III [Madrid] (ISC), Department of Nutrition and Metabolism, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Department of Food Science and Human Nutrition, Agricultural University of Athens, Institute for Medical Research, University of Belgrade [Belgrade], School of Food Science and Nutrition, University of Leeds, Department of Nutrition & Dietetics, King's College London's Faculty of Life Sciences & Medicine, Laboratory of Hygiene and Environmental Protection, Medical School of Democritus University of Thrace, Teagasac Food Research Centre, UCD Institute of Food and Health, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), COST (European Cooperation in Science and Technology): FA1403-POSITIVe, COST Action 'POSITIVe' FA1403, Quadram Institute Bioscience [Norwich, U.K.] (QIB), Biotechnology and Biological Sciences Research Council (BBSRC), Instituto de Salud Carlos III (ISC), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), European Commission, European Cooperation in Science and Technology, Universitat de Barcelona, Garcia-Conesa, Maria Theresa, and Gonzalez-Sarrias, Antonio

Subjects
0301 basic medicine, Trastorns del metabolisme, Chimie analytique, Review, Overweight, Interindividual variability, Cardiovascular System, Pomegranate, interindividual variability, Anthocyanins, lcsh:Chemistry, chemistry.chemical_compound, pomegranate, Risk Factors, cardiovascular disease, Ellagitannins, maladie cardiovasculaire, Nuts, Food science, lcsh:QH301-705.5, Spectroscopy, 2. Zero hunger, digestive, oral, and skin physiology, Red wine, food and beverages, Berries, General Medicine, red wine, anthocyanins, Hydrolyzable Tannins, 3. Good health, Computer Science Applications, Lifestyle factors, Disorders of metabolism, Cardiovascular Diseases, Meta-analysis, Polifenols, Alimentation et Nutrition, Smoking status, medicine.symptom, metaanalysis, cardiometabolic disorders, berries, Waist, nuts, Biology, Catalysis, Cardiovascular Physiological Phenomena, Inorganic Chemistry, 03 medical and health sciences, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Red grapes, ellagitannins, Cardiometabolic disorders, medicine, méta analyse, Food and Nutrition, Humans, Physical and Theoretical Chemistry, Molecular Biology, Wine, meta-analysis, red grapes, 030109 nutrition & dietetics, Myocardium, Organic Chemistry, polyphénol alimentaire, Polyphenols, Diet, lcsh:Biology (General), lcsh:QD1-999, chemistry, Food, Polyphenol, Anthocyanin, Dietary Supplements, Energy Metabolism, Analytical chemistry, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Biomarkers
Abstract

Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin- and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose were most significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation., This article is based upon work from COST Action FA1403—POSITIVe “Interindividual variation in response to consumption of plant food bioactives and determinants involved” supported by COST (European Cooperation in Science and Technology, http://www.cost.eu/). The authors thank the financial support of the COST Action FA1403 “POSITIVe” to conduct a short-term scientific mission to K.C. at CEBAS-CSIC (A.G.-S. and M.T.G.-C.) during which the data analysis was performed.

Published
2018
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40. Aronia-citrus juice (polyphenol-rich juice) intake and elite triathlon training: a lipidomic approach using representative oxylipins in urine

Author

Angel Gil-Izquierdo, Cristina Gómez, Federico Ferreres, Camille Oger, Roberto Cejuela, Thierry Durand, José Miguel Martínez-Sanz, Jean-Marie Galano, Álvaro Hernández-Sáez, Sonia Medina, Craig E. Wheelock, Libia Alejandra García-Flores, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Karolinska Institutet [Stockholm], Universidad de Alicante, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Universidad de Murcia, Universidad de Alicante. Departamento de Didáctica General y Didácticas Específicas, Universidad de Alicante. Departamento de Enfermería, Research in Physical Education, Fitness and Performance (RIPEFAP), and Grupo de Investigación en Alimentación y Nutrición (ALINUT)

Subjects
0301 basic medicine, Adult, Male, Citrus, [SDV]Life Sciences [q-bio], Urine, medicine.disease_cause, Cardiovascular System, Excretion, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, Photinia, Educación Física y Deportiva, medicine, Urinary oxylipins, Training, Humans, Food science, Oxylipins, Chromatography, High Pressure Liquid, Juice, Polyphenols, Resistance Training, General Medicine, Lipid Metabolism, Isoprostanes, Eicosapentaenoic acid, Lipids, 6. Clean water, Fruit and Vegetable Juices, Oxidative Stress, 030104 developmental biology, chemistry, Biochemistry, Polyphenol, Athletes, Enfermería, lipids (amino acids, peptides, and proteins), Arachidonic acid, Female, Aronia, Oxidative stress, Food Science
Abstract

In the present study, we examined whether particular urinary oxylipins (isoprostanes (IsoPs), leukotrienes (LTs), prostaglandins (PGs), and thromboxanes (TXs)) in 16 elite triathletes could alter during 145 days of training. Within this time span, 45 days were dedicated to examining the effects of the intake of a beverage rich in polyphenols (one serving: 200 mL per day) supplemented in their diet. The beverage was a mixture of citrus juice (95%) and Aronia melanocarpa juice (5%) (ACJ). Fifty-two oxylipins were analyzed in the urine. The quantification was carried out using solid-phase extraction, liquid chromatography coupled with triple quadrupole mass spectrometry. The physical activity decreased the excretion of some PG, IsoP, TX, and LT metabolites from arachidonic acid, γ-dihomo-linolenic acid, and eicosapentaenoic acid. The ACJ also reduced the excretion of 2,3-dinor-11β-PGF2α and 11-dehydro-TXB2, although the levels of other metabolites increased after juice supplementation (PGE2, 15-keto-15-F2t-IsoP, 20-OH-PGE2, LTE4, and 15-epi-15-E2t-IsoP), compared to the placebo. The metabolites that increased in abundance have been related to vascular homeostasis and smooth muscle function, suggesting a positive effect on the cardiovascular system. In conclusion, exercise influences mainly the decrease in oxidative stress and the inflammation status in elite triathletes, while ACJ supplementation has a potential benefit regarding the cardiovascular system that is connected in a synergistic manner with elite physical activity. This study was supported by the Project AGL2011-23690 (CICYT) (Spanish Ministry of Economy and Competitiveness). This work was partially funded by the “Fundación Séneca de la Región de Murcia” Grupo de Excelencia 19900/GERM/15. This work is included in the framework of the collaboration between the Spanish Research Council (CEBAS-CSIC) and CNRS-University of Montpellier as “Projets Internationaux de Cooperation Scientifique” (PICS-2015-261141). LAGF was granted a pre-doctoral FPI fellowship by the Spanish government as well as a scholarship that allowed the collaboration with Dr Craig Wheelock’s group (Department of Medical Biochemistry and Biophysics (MBB)) at the Karolinska Institute. The authors are also grateful to the University of Alicante for its collaboration. Sonia Medina was appointed under a research contract from the Project AGL2011-23690 (CICYT).

Published
2017
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41. Comparative Study of the Phytoprostane and Phytofuran Content of indica and japonica Rice (Oryza sativa L.) Flours

Author

Angel Gil-Izquierdo, Federico Ferreres, M. Pinciroli, Jean-Marie Galano, Raúl Domínguez-Perles, Camille Oger, Thierry Durand, Alexandre Guy, Ángel Abellán, Universidad Nacional de la Plata [Argentine] (UNLP), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)

Subjects
0301 basic medicine, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, brown rice flour, Oxidative degradation, Flour, brown rice flour, Japonica, Lipid peroxidation, 03 medical and health sciences, chemistry.chemical_compound, 0404 agricultural biotechnology, white rice flour, phytofurans, Cultivar, Food science, Ciencias Agrarias, Furans, 2. Zero hunger, rice bran, Oryza sativa, biology, Bran, Plant Extracts, food and beverages, Oryza, 04 agricultural and veterinary sciences, General Chemistry, phytoprostanes, biology.organism_classification, 040401 food science, Japonica rice, Bioavailability, 030104 developmental biology, Agronomy, chemistry, processing, white rice flour, General Agricultural and Biological Sciences
Abstract

Phytoprostanes and phytofurans (PhytoPs and PhytoFs, respectively) are nonenzymatic lipid peroxidation products derived from α-linolenic acid (C18:3 n-3), considered biomarkers of oxidative degradation in plant foods. The present work profiled these compounds in white and brown grain flours and rice bran from 14 rice cultivars of the subspecies indica and japonica by ultrahigh performance liquid chromatography coupled to electrospray ionization and triple quadrupole mass spectrometry. For PhytoPs, the average concentrations were higher in rice bran (0.01−9.35 ng g−1) than in white and brown grain flours (0.01−1.17 ng g−1). In addition, the evaluation of rice flours for the occurrence PhytoFs evidenced average values 1.77, 4.22, and 10.30 ng g−1 dw in rice bran, brown grain flour, and white grain flour, respectively. A significant correlation was observed between total and individual compounds. The concentrations retrieved suggest rice bran as a valuable source of PhytoPs and PhytoFs that should be considered in further studies on bioavailability and bioactivity of such compounds., Facultad de Ciencias Agrarias y Forestales

Published
2017
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42. Strategies for greenhouse gas emissions mitigation in Mediterranean agriculture: A review

Author

Maria Luz Cayuela, Gilles Billen, S. Menéndez, Raúl Moral, Guillermo Guardia, S. González-Ubierna, Eugenio Díaz-Pinés, Jordi Doltra, H. Arriaga, Luis Lassaletta, Berta Sánchez, María José Sanz, Eduardo Aguilera, I. Puigdueta-Bartolomé, Jorge Álvaro-Fuentes, Miguel Quemada, Juan Infante-Amate, H. van Grinsven, Henk Westhoek, Pete Smith, Elena Galán, Guillermo Pardo, A. del Prado, D. Báez, Alberto Sanz-Cobena, Fernando Estellés, Diego Abalos, Antonio Vallejo, Pilar Merino, J. Le-Noë, Josette Garnier, Salvador Calvet, C. Gilsanz, Ana Meijide, Benjamín S. Gimeno, Ana Iglesias, Daniel Plaza-Bonilla, Ministerio de Economía y Competitividad (España), Eusko Jaurlaritza, Fundación Séneca, ETSI Agronomos, Universidad Politécnica de Madrid (UPM), Netherlands Environmental Assessment Agency, Universidad Pablo de Olavide [Sevilla] (UPO), Basque Centre for Climate Change, Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols (METIS), Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC), Department of Soil Quality, Wageningen University and Research [Wageningen] (WUR), AGroécologie, Innovations, teRritoires (AGIR), Institut National de la Recherche Agronomique (INRA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), Department of Agrochemistry and Environment, Miguel Hernandez University (UMH), Conservation of Natural Resources, Instituto Vasco de Investigación y Desarrollo Agrario [Derio] (NEIKER), Bioclimatology, Georg-August-University = Georg-August-Universität Göttingen, Soil and Water Dpt, Estación, Experimental de Aula Dei (EEAD), Spanish National Research Council (CSIC), Mabegondo Agricultural Research Centre, Centro de Investigaciones Agrarias de Mabegondo (CIAM), Cantabrian Agricultural Research and Training Centre, Faculty of Pharmacy, University of Valencia, Centro de Edafologia y Biologia Aplicada del Segura, Department of Plant Biology and Ecology, University of the Basque Country, Institut für Meteorologie und Klimaforschung - Atmosphärische Umweltforschung (IMK-IFU), Karlsruher Institut für Technologie (KIT), Institute of Animal Science and Technology (ICTA), Universitat Politècnica de València (UPV), Ecotoxicology of Air Pollution, Ecotoxicology of Air Pollution (CIEMAT), Institute of Biological and Environmental Sciences, (SFIRC), Technical University of Madrid, Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Georg-August-University [Göttingen], Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
Mediterranean climate, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, Crop residue, Mitigation, Cropping systems, Review, 010501 environmental sciences, Carbon sequestration, PRODUCCION ANIMAL, 01 natural sciences, Environmental protection, Agricultural productivity, Cover crop, Bodembiologie, 0105 earth and related environmental sciences, Ecology, business.industry, Agroforestry, 04 agricultural and veterinary sciences, Soil Biology, Manure, 13. Climate action, Agriculture, Greenhouse gas, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Environmental science, Animal Science and Zoology, GHG, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, business, Agronomy and Crop Science
Abstract

88 Pags.- 4 Figs.- 3 Tabls. The definitive version is available at: http://www.sciencedirect.com/science/journal/01678809 This article belongs to a special issue "Quantification and mitigation of greenhouse gas emissions in Mediterranean cropping systems" / Edited By Alberto Sanz-Cobena, Luis Lassaletta, Josette Garnier and Pete Smith, available at http://www.sciencedirect.com/science/journal/01678809/238/supp/C, An integrated assessment of the potential of different management practices for mitigating specific components of the total GHG budget (N2O and CH4 emissions and C sequestration) of Mediterranean agrosystems was performed in this study. Their suitability regarding both yield and environmental (e.g. nitrate leaching and ammonia volatilization) sustainability, and regional barriers and opportunities for their implementation were also considered. Based on its results best strategies to abate GHG emissions in Mediterranean agro-systems were proposed. Adjusting N fertilization to crop needs in both irrigated and rain-fed systems could reduce N2O emissions up to 50% compared with a non-adjusted practice. Substitution of N synthetic fertilizers by solid manure can be also implemented in those systems, and may abate N2O emissions by about 20% under Mediterranean conditions, with additional indirect benefits associated to energy savings and positive effects in crop yields. The use of urease and nitrification inhibitors enhances N use efficiency of the cropping systems and may mitigate N2O emissions up to 80% and 50%, respectively. The type of irrigation may also have a great mitigation potential in the Mediterranean region. Drip-irrigated systems have on average 80% lower N2O emissions than sprinkler systems and drip-irrigation combined with optimized fertilization showed a reduction in direct N2O emissions up to 50%. Methane fluxes have a relatively small contribution to the total GHG budget of Mediterranean crops, which can mostly be controlled by careful management of the water table and organic inputs in paddies. Reduced soil tillage, improved management of crop residues and agro-industry by-products, and cover cropping in orchards, are the most suitable interventions to enhance organic C stocks in Mediterranean agricultural soils. The adoption of the proposed agricultural practices will require farmers training. The global analysis of life cycle emissions associated to irrigation type (drip, sprinkle and furrow) and N fertilization rate (100 and 300 kg N ha−1 yr−1) revealed that these factors may outweigh the reduction in GHG emissions beyond the plot scale. The analysis of the impact of some structural changes on top-down mitigation of GHG emissions revealed that 3–15% of N2O emissions could be suppressed by avoiding food waste at the end-consumer level. A 40% reduction in meat and dairy consumption could reduce GHG emissions by 20–30%. Reintroducing the Mediterranean diet (i.e. ∼35% intake of animal protein) would therefore result in a significant decrease of GHG emissions from agricultural production systems under Mediterranean conditions., The authors would like to thank the Spanish National R+D+i Plan (AGL2012-37815-C05-01, AGL2012-37815-C05-04) and very specifically the workshop held in December 2016 in Butrón (Bizkaia) to synthesize the most promising measures to reduce N2O emissions from Spanish agricultural soils. BC3 is sponsored by the Basque Government. M. L. Cayuela thanks Fundación Seneca for financing the project 19281/PI/14. This paper has been produced within the context of the REMEDIA network: http://redremedia.wordpress.com/.

Published
2017
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43. Interindividual Variability in Biomarkers of Cardiometabolic Health after Consumption of Major Plant-Food Bioactive Compounds and the Determinants Involved

Author

Dragan Milenkovic, Ana Rodriguez-Mateos, Francisco A. Tomás-Barberán, Jose M. Ordovas, Christine Morand, Aedin Cassidy, Paul A. Kroon, Aleksandra Konić-Ristić, Raffaele De Caterina, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, School of Food Science and Nutrition, University of Leeds, Research Group on Quality, Safety and Bioactivity of Plant Foods, Centro de Edafologia y Biologia Aplicada del Segura, Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University [Medford], Food and Health Programme, Institute of Food Research, Norwich Research Park, Institute of Clinical Physiology, National Council of Research, Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University of Dusseldorf, COST (European Cooperation in Science and Technology), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), University of East Anglia [Norwich] (UEA), and Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]

Subjects
0301 basic medicine, Male, and promotion of well-being, obesity, biological responsiveness, Phytochemicals, Medicine (miscellaneous), Type 2 diabetes, Health benefits, Plant foods, Cardiovascular, human health, Oral and gastrointestinal, interindividual variability, chemistry.chemical_compound, Risk Factors, cardiovascular disease, maladie cardiovasculaire, Cause of death, Randomized Controlled Trials as Topic, 2. Zero hunger, Metabolic Syndrome, Nutrition and Dietetics, syndrome métabolique, metabolic x syndrome, santé humaine, Bioactive compound, 3. Good health, Stroke, obésité, Cardiovascular Diseases, Female, variabilité inter individuelle, Type 2, cardiometabolic health, diabète de type 2, aliment d'origine végétale, Reviews, Biology, Health outcomes, 03 medical and health sciences, Sex Factors, determinants of interindividual variability, Genetic, SDG 3 - Good Health and Well-being, Environmental health, medicine, Diabetes Mellitus, Humans, Obesity, Polymorphism, 3.3 Nutrition and chemoprevention, Metabolic and endocrine, Nutrition, 030109 nutrition & dietetics, Polymorphism, Genetic, business.industry, Polyphenols, medicine.disease, Prevention of disease and conditions, type ii diabetes, Biotechnology, Good Health and Well Being, chemistry, Diabetes Mellitus, Type 2, plant-food bioactives, Metabolic syndrome, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Biomarkers, Food Science
Abstract

We acknowledge networking support by the COST Action FA 1403 POSITIVe (interindividual variation in response to consumption of plant food bioactives and determinants involved), supported by COST (European Cooperation in Science and Technology); Cardiometabolic disease, comprising cardiovascular diseases, type 2 diabetes, and their associated risk factors including metabolic syndrome and obesity, is the leading cause of death worldwide. Plant foods are rich sources of different groups of bioactive compounds, which might not be essential throughout life but promote health and well-being by reducing the risk of age-related chronic diseases. However, heterogeneity in the responsiveness to bioactive compounds can obscure associations between their intakes and health outcomes, resulting in the hiding of health benefits for specific population groups and thereby limiting our knowledge of the exact role of the different bioactive compounds for health. The heterogeneity in response suggests that some individuals may benefit more than others from the health effects of these bioactive compounds. However, to date, this interindividual variation after habitual intake of plant bioactive compounds has been little explored. The aim of this review is to provide an overview of the existing research that has revealed interindividual variability in the responsiveness to plant-food bioactive compound consumption regarding cardiometabolic outcomes, focusing on polyphenols, caffeine and plant sterols, and the identified potential determinants involved.

Published
2017
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44. The database of the Predicts (Projecting responses of ecological diversity in changing terrestrial systems) project

Author

Hudson, LN, Newbold, T, Contu, S, Hill, SLL, Lysenko, I, De Palma, A, Phillips, HRP, Alhusseini, TI, Bedford, FE, Bennett, DJ, Booth, H, Burton, VJ, Chng, CWT, Choimes, A, Correia, DLP, Day, J, Echeverría-Londoño, S, Emerson, SR, Gao, D, Garon, M, Harrison, MLK, Ingram, DJ, Jung, M, Kemp, V, Kirkpatrick, L, Martin, CD, Pan, Y, Pask-Hale, GD, Pynegar, EL, Robinson, AN, Sanchez-Ortiz, K, Senior, RA, Simmons, BI, White, HJ, Zhang, H, Aben, J, Abrahamczyk, S, Adum, GB, Aguilar-Barquero, V, Aizen, MA, Albertos, B, Alcala, EL, del Mar Alguacil, M, Alignier, A, Ancrenaz, M, Andersen, AN, Arbeláez-Cortés, E, Armbrecht, I, Arroyo-Rodríguez, V, Aumann, T, Axmacher, JC, Azhar, B, Azpiroz, AB, Baeten, L, Bakayoko, A, Báldi, A, Banks, JE, Baral, SK, Barlow, J, Barratt, BIP, Barrico, L, Bartolommei, P, Barton, DM, Basset, Y, Batáry, P, Bates, AJ, Baur, B, Bayne, EM, Beja, P, Benedick, S, Berg, Å, Bernard, H, Berry, NJ, Bhatt, D, Bicknell, JE, Bihn, JH, Blake, RJ, Bobo, KS, Bóçon, R, Boekhout, T, Böhning-Gaese, K, Bonham, KJ, Borges, PAV, Borges, SH, Boutin, C, Bouyer, J, Bragagnolo, C, Brandt, JS, Brearley, FQ, Brito, I, Bros, V, Brunet, J, Buczkowski, G, Buddle, CM, Bugter, R, Buscardo, E, Buse, J, Cabra-García, J, Cáceres, NC, Cagle, NL, Calviño-Cancela, M, Cameron, SA, Cancello, EM, Caparrós, R, Cardoso, P, Carpenter, D, Carrijo, TF, Carvalho, AL, Cassano, CR, Castro, H, Castro-Luna, AA, Rolando, CB, Cerezo, A, Chapman, KA, Chauvat, M, Christensen, M, Clarke, FM, Cleary, DFR, Colombo, G, Connop, SP, Craig, MD, Cruz-López, L, Cunningham, SA, D'Aniello, B, D'Cruze, N, da Silva, PG, Dallimer, M, Danquah, E, Darvill, B, Dauber, J, Davis, ALV, Dawson, J, de Sassi, C, de Thoisy, B, Deheuvels, O, Dejean, A, Devineau, J-L, Diekötter, T, Dolia, JV, Domínguez, E, Dominguez-Haydar, Y, Dorn, S, Draper, I, Dreber, N, Dumont, B, Dures, SG, Dynesius, M, Edenius, L, Eggleton, P, Eigenbrod, F, Elek, Z, Entling, MH, Esler, KJ, de Lima, RF, Faruk, A, Farwig, N, Fayle, TM, Felicioli, A, Felton, AM, Fensham, RJ, Fernandez, IC, Ferreira, CC, Ficetola, GF, Fiera, C, Filgueiras, BKC, Fırıncıoğlu, HK, Flaspohler, D, Floren, A, Fonte, SJ, Fournier, A, Fowler, RE, Franzén, M, Fraser, LH, Fredriksson, GM, Freire, GB, Frizzo, TLM, Fukuda, D, Furlani, D, Gaigher, R, Ganzhorn, JU, García, KP, Garcia-R, JC, Garden, JG, Garilleti, R, Ge, B-M, Gendreau-Berthiaume, B, Gerard, PJ, Gheler-Costa, C, Gilbert, B, Giordani, P, Giordano, S, Golodets, C, Gomes, LGL, Gould, RK, Goulson, D, Gove, AD, Granjon, L, Grass, I, Gray, CL, Grogan, J, Gu, W, Guardiola, M, Gunawardene, NR, Gutierrez, AG, Gutiérrez-Lamus, DL, Haarmeyer, DH, Hanley, ME, Hanson, T, Hashim, NR, Hassan, SN, Hatfield, RG, Hawes, JE, Hayward, MW, Hébert, C, Helden, AJ, Henden, J-A, Henschel, P, Hernández, L, Herrera, JP, Herrmann, F, Herzog, F, Higuera-Diaz, D, Hilje, B, Höfer, H, Hoffmann, A, Horgan, FG, Hornung, E, Horváth, R, Hylander, K, Isaacs-Cubides, P, Ishida, H, Ishitani, M, Jacobs, CT, Jaramillo, VJ, Jauker, B, 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B., Simonetti, Javier A., Slade, Eleanor M., Smith, Jo, Smith Pardo, Allan H., Sodhi, Navjot S., Somarriba, Eduardo J., Sosa, Ramón A., Soto Quiroga, Grimaldo, St Laurent, Martin Hugue, Starzomski, Brian M., Stefanescu, Constanti, Steffan Dewenter, Ingolf, Stouffer, Philip C., Stout, Jane C., Strauch, Ayron M., Struebig, Matthew J., Su, Zhimin, Suarez Rubio, Marcela, Sugiura, Shinji, Summerville, Keith S., Sung, Yik Hei, Sutrisno, Hari, Svenning, Jens Christian, Teder, Tiit, Threlfall, Caragh G., Tiitsaar, Anu, Todd, Jacqui H., Tonietto, Rebecca K., Torre, Ignasi, Tóthmérész, Béla, Tscharntke, Teja, Turner, Edgar C., Tylianakis, Jason M., Uehara Prado, Marcio, Urbina Cardona, Nicola, Vallan, Deni, Vanbergen, Adam J., Vasconcelos, Heraldo L., Vassilev, Kiril, Verboven, Hans A. F., Verdasca, Maria João, Verdú, José R., Vergara, Carlos H., Vergara, Pablo M., Verhulst, Jort, Virgilio, Massimiliano, Vu, Lien Van, Waite, Edward M., Walker, Tony R., Wang, Hua Feng, Wang, Yanping, Watling, James I., Weller, Britta, Wells, Konstan, Westphal, Catrin, Wiafe, Edward D., Williams, Christopher D., Willig, Michael R., Woinarski, John C. Z., Wolf, Jan H. D., Wolters, Volkmar, Woodcock, Ben A., Wu, Jihua, Wunderle, Joseph M., Yamaura, Yuichi, Yoshikura, Satoko, Yu, Douglas W., Zaitsev, Andrey S., Zeidler, Juliane, Zou, Fasheng, Collen, Ben, Ewers, Rob M., Mace, Georgina M., Purves, Drew W., Scharlemann, Jörn P. W., Purvis, Andy, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), Institut National de la Recherche Agronomique - INRA (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Natural History Museum, 3Department of Genetics, Evolution and Environment, Centre for Biodiversity and Environment, Research, University College London ( UCL ), Department of Life Sciences, Universita di Trieste, Auburn University, Queen Mary University of London ( QMUL ), Royal Holloway [University of London] ( RHUL ), ( SFIRC ), University of Antwerp ( UA ), University of Bonn (Rheinische Friedrich-Wilhelms), Kwame Nkrumah University of Science and Technology ( KNUST ), Universidad de Costa Rica, Laboratorio Ecotono-CRUB, Universidad Nacional del Comahue, SAD Paysage ( SAD Paysage ), Institut National de la Recherche Agronomique ( INRA ) -AGROCAMPUS OUEST, Dynamiques Forestières dans l'Espace Rural ( DYNAFOR ), Institut National Polytechnique [Toulouse] ( INP ) -Institut National de la Recherche Agronomique ( INRA ) -Ecole Nationale Supérieure Agronomique de Toulouse, Contrôle des maladies animales exotiques et émergentes [Montpellier] ( CMAEE ), Institut National de la Recherche Agronomique ( INRA ) -Centre de coopération internationale en recherche agronomique pour le développement [CIRAD] : UMR15, Unité Mixte de Recherches sur les Herbivores ( UMR 1213 Herbivores ), VetAgro Sup ( VAS ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique ( INRA ), Centre de Biologie pour la Gestion des Populations ( CBGP ), Centre de Coopération Internationale en Recherche Agronomique pour le Développement ( CIRAD ) -Centre international d'études supérieures en sciences agronomiques ( Montpellier SupAgro ) -Institut national de la recherche agronomique [Montpellier] ( INRA Montpellier ) -Université de Montpellier ( UM ) -Institut de Recherche pour le Développement ( IRD [France-Sud] ) -Institut national d’études supérieures agronomiques de Montpellier ( Montpellier SupAgro ), Abeilles et Environnement ( AE ), and Institut National de la Recherche Agronomique ( INRA ) -Université d'Avignon et des Pays de Vaucluse ( UAPV )

Subjects
VDP::Mathematics and natural science: 400::Zoology and botany: 480::Ecology: 488, Biodiversité et Ecologie, data sharing, habitat, Biológiai tudományok, Q1, BIRD SPECIES RICHNESS, TROPICAL DRY FOREST, VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økologi: 488, MEXICAN COFFEE PLANTATIONS, Természettudományok, Data and Information, Milieux et Changements globaux, LOWLAND, ComputingMilieux_MISCELLANEOUS, Original Research, Ecology, global biodiversity modeling, global change, habitat destruction, land use, Ecology, Evolution, Behavior and Systematics, Nature and Landscape Conservation, LAND-USE CHANGE, [ SDE.MCG ] Environmental Sciences/Global Changes, Chemistry, Earth and Related Environmental Sciences, Evolution, [SDE.MCG]Environmental Sciences/Global Changes, INTENSIVELY MANAGED FARMLAND, Ingénierie de l'environnement, CARABID BEETLE ASSEMBLAGES, FRUIT-FEEDING BUTTERFLIES, Ecology and Environment, Biodiversity and Ecology, keywords: data sharing, Behavior and Systematics, Biology, Ekologi, [ SDE.BE ] Environmental Sciences/Biodiversity and Ecology, QL, DIPTEROCARP FOREST, QH, PLANT COMMUNITY COMPOSITION, Geovetenskap och miljövetenskap, Biology and Life Sciences, destruction, Ecology, Evolution, Behavior and Systematic, URBAN-RURAL GRADIENT, Earth and Environmental Sciences, Environnement et Société, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract

Source at https://doi.org/10.1002/ece3.2579. The PREDICTS project—Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)—has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.

Published
2017
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45. Effect of the dietary intake of melatonin-and hydroxytyrosol-rich wines by healthy female volunteers on the systemic lipidomic-related oxylipins

Author

Camille Oger, Pedro Martínez-Hernández, Simón Arina, Juan José López-García, Javier Marhuenda, Antonio Solana, Juana Mulero, Pilar Zafrilla, Thierry Durand, Sonia Medina, Angel Gil-Izquierdo, Federico Ferreres, Jean-Marie Galano, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidad Católica San Antonio de Murcia (UCAM), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), and Universidad de Murcia

Subjects
0301 basic medicine, Adult, Antioxidant, Adolescent, medicine.medical_treatment, Prostaglandin, Wine, Biology, Pharmacology, medicine.disease_cause, 01 natural sciences, Excretion, Melatonin, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, Phenols, medicine, Humans, Oxylipins, 010401 analytical chemistry, food and beverages, General Medicine, Phenylethyl Alcohol, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Isoprostanes, Healthy Volunteers, 0104 chemical sciences, Oxidative Stress, 030104 developmental biology, chemistry, Biochemistry, Hydroxytyrosol, Female, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Oxidative stress, Food Science, medicine.drug
Abstract

International audience; Oxylipins are lipid mediators involved in the physiopathology of all organs. Moreover, isoprostanes have been established as general and reliable in vivo oxidative stress biomarkers. Red wine has proved to exert several benefits through the maintenance of the oxidative balance of the organism. Antiradical scavenging capacity has been mainly attributed to polyphenols. However, melatonin and hydroxytyrosol should be taken into account as potent antiradical agents. The present research aimed to clarify the situation of enzymatic and oxidative injury and eicosanoid urinary excretion related to the intake of three kinds of red wines and their primary musts. Judging by the reduction in the excretion of isoprostanes, red wine consumption exhibited the highest antioxidant protection against oxidative stress, attributed to its OHTyr content (p < 0.05), and to a lesser extent to its MEL content. Similarly, the intake of red wine leads to the cardioprotective effect due to the reduction in the urinary excretion of the pro-inflammatory prostaglan-din 2,3-dinor-11-β-PGF 2α , besides the increase in the vasodilator prostaglandin PGE 1 , mediated by the melatonin (p < 0.05) and hydroxytyrosol (p < 0.05) contents. In conclusion, red wine (especially non-aged wine) exerts a higher in vivo antioxidant capacity than must or alcohol.

Published
2017
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46. Production of low-Cs+ rice plants by inactivation of the K+ transporter OsHAK1 with the CRISPR-Cas system

Author

Natsuko I. Kobayashi, Sonia Mohamed, Keitaro Tanoi, Aurore Vernet, Manuel Nieves-Cordones, Christophe Périn, Hervé Sentenac, Keiko Takagi, Emmanuel Guiderdoni, Anne-Aliénor Véry, Biochimie et Physiologie Moléculaire des Plantes (BPMP), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Departamento de Nutrición Vegetal, Centro de Edafologia y Biologia Aplicada del Segura, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Graduate School of Agricultural and Life Sciences, Japan Science and Technology Agency (JST), JST, PRESTO, Université de Montpellier (UM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Nieves-Cordones, Manuel, and Véry, Anne-Aliénor

Subjects
0106 biological sciences, 0301 basic medicine, soil contamination by radioactivity, Plant Science, 01 natural sciences, HAKI, F01 - Culture des plantes, CRISPR-Cas, Rice plant, riz, 2. Zero hunger, Vegetal Biology, radiocesium, Sol pollué, food and beverages, Contamination, Soil contamination, radioactive contamination, Physiologie végétale, Horticulture, Shoot, Q03 - Contamination et toxicologie alimentaires, Fertilizer, root absorption, P02 - Pollution, F60 - Physiologie et biochimie végétale, contamination environnementale, Césium, Biology, engineering.material, Absorption, 03 medical and health sciences, contamination radioactive, cesium, Botany, Genetics, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Oryza sativa, rice, Transporter, Cell Biology, 15. Life on land, Yeast, 030104 developmental biology, oryza sativa, absorption racinaire, 13. Climate action, engineering, Biologie végétale, 010606 plant biology & botany
Abstract

Summary Occurrence of radiocesium in food has raised sharp health concerns after nuclear accidents. Despite being present at low concentrations in contaminated soils (below μM), cesium (Cs+) can be taken up by crops and transported to their edible parts. Such a plant capacity to take up Cs+ from low concentrations has notably affected the production of rice (Oryza sativa L.) in Japan after the nuclear accident at Fukushima in 2011. Several strategies have been put into practice to reduce Cs+ content in this crop species, such as contaminated soil removal or adaptation of agricultural practices, including dedicated fertilizer management, with limited impact or pernicious side effects. On the other hand, development of biotechnological approaches aiming at reducing Cs+ accumulation in rice remained challenging. Here, we show that inactivation of the Cs+-permeable K+ transporter OsHAK1 with the CRISPR-Cas system dramatically reduced Cs+ uptake by rice plants. Cs+ uptake in rice roots and in transformed yeast cells expressing OsHAK1 displayed very similar kinetics parameters. In rice, Cs+ uptake is dependent on two functional properties of OsHAK1: (i) a poor capacity of this system to discriminate between Cs+ and K+, and (ii) a high capacity to transport Cs+ from very low external concentrations, which is likely to involve an active transport mechanism. In an experiment with a Fukushima soil highly contaminated with 137Cs+, plants lacking OsHAK1 function displayed strikingly reduced levels of 137Cs+ in roots and shoots. These results open stimulating perspectives to smartly produce safe food in regions contaminated by nuclear accidents. This article is protected by copyright. All rights reserved.

Published
2017
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47. Addressing the inter-individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction

Author

Tom Van de Wiele, Eileen R. Gibney, Francisco A. Tomás-Barberán, Rikard Landberg, Dragan Milenkovic, Maria Theresa Garcia-Conesa, Ana Rodriguez-Mateos, Baukje de Roos, Marina Heinonen, Christine Morand, Claudine Manach, European Cooperation in Science and Technology, European Commission, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Center for Microbial Ecology and Technology (CMET), Universiteit Gent = Ghent University [Belgium] (UGENT), Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Düsseldorf, Rowett Institute of Nutrition and Health, University of Aberdeen, Centro de Edafologia y Biologia Aplicada del Segura, Department of Food Science, Cornelle University, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan], Institute of Food and Health, University College Dublin [Dublin] (UCD), Department of Food and Environmental Sciences, Food Chemistry, University of Helsinki, COST (European Cooperation in Science and Technology):FA1403 POSITIVe, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Ghent University [Belgium] (UGENT), Universiteit Gent = Ghent University (UGENT), and Helsingin yliopisto = Helsingfors universitet = University of Helsinki

Subjects
Agriculture and Food Sciences, 0301 basic medicine, and promotion of well-being, biological responsiveness, Health Behavior, Phytochemicals, VEGETABLE CONSUMPTION, Review, bioavailability and metabolism, BLOOD MONONUCLEAR-CELLS, Inter‐individual variation, Cardiovascular, Plant foods, nutrition préventive, Oral and gastrointestinal, Inter-individual variation, Healthy Aging, Risk Factors, cardiovascular disease, GENETIC-VARIANTS, maladie cardiovasculaire, Biological responsiveness, Randomized Controlled Trials as Topic, 2. Zero hunger, Cardiometabolic risk, Nutrition and Dietetics, Cardiometabolic health, RANDOMIZED CONTROLLED-TRIAL, Plants, 3. Good health, Stroke, Variation (linguistics), POSTMENOPAUSAL WOMEN, CARDIOVASCULAR-DISEASE, Cardiovascular Diseases, plant food bioactives, Public Health and Health Services, CORONARY-ARTERY-DISEASE, Diet, Healthy, Plants, Edible, variabilité inter individuelle, Biotechnology, cardiometabolic health, Bioavailability and metabolism, education, Reviews, HEART-DISEASE, Biology, Affect (psychology), 03 medical and health sciences, Edible, Food Sciences, Metabolic Diseases, Environmental health, inter-individual variation, Humans, Obesity, Healthy aging, 3.3 Nutrition and chemoprevention, Metabolic and endocrine, Nutrition, INTERVENTION TRIAL, Consumption (economics), Healthy, 030109 nutrition & dietetics, Nutrition & Dietetics, business.industry, Prevention, PRODUCER PHENOTYPE, Prevention of disease and conditions, Diet, Review article, Good Health and Well Being, alimentation végétale, Plant food bioactives, Position paper, business, Risk Reduction Behavior, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Food Science
Abstract

Bioactive compounds in plant-based foods have health properties that contribute to the prevention of age-related chronic diseases, particularly cardiometabolic disorders. Conclusive proof and understanding of these benefits in humans is essential in order to provide effective dietary recommendations but, so far, the evidence obtained from human intervention trials is limited and contradictory. This is partly due to differences between individuals in the absorption, distribution, metabolism and excretion of bioactive compounds, as well as to heterogeneity in their biological response regarding cardiometabolic health outcomes. Identifying the main factors underlying inter-individual differences, as well as developing new and innovative methodologies to account for such variability constitute an overarching goal to ultimately optimize the beneficial health effects of plant food bioactives for each and every one of us. In this respect, this position paper from the COST Action FA1403-POSITIVe examines the main factors likely to affect the individual responses to consumption of plant food bioactives and presents perspectives for assessment and consideration of inter-individual variability., The authors would like to acknowledge networking support by the COST Action FA 1403 POSITIVe (Inter-individual variation in response to consumption of plant food bioactives and determinants involved), supported by COST (European Cooperation in Science and Technology).

Published
2017
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48. The Value of Legume Foods as a Dietary Source of Phytoprostanes and Phytofurans Is Dependent on Species, Variety, and Growing Conditions

Author

Camille Oger, Thierry Durand, Federico Ferreres, Catalina Egea-Gilabert, Raúl Domínguez-Perles, Angel Gil-Izquierdo, Mercedes del Río Celestino, Juan A. Fernández, María del Carmen García-García, Jean M. Galano, Centro La Mojonera, Instituto Andaluz de Investigación y Formación Agraria y Pesquera (IFAPA), Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Technical University of Cartagena (UPTC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
2. Zero hunger, 0303 health sciences, biology, 030309 nutrition & dietetics, Abiotic stress, Deficit irrigation, food and beverages, Plant physiology, 04 agricultural and veterinary sciences, General Chemistry, biology.organism_classification, 040401 food science, Industrial and Manufacturing Engineering, Pisum, 03 medical and health sciences, 0404 agricultural biotechnology, Sativum, Cultivar, Food science, Phaseolus, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Legume, Food Science, Biotechnology
Abstract

Bioactive phytoprostanes and phytofurans are synthesized in higher plants by non‐enzymatic oxidation of α‐linolenic acid (C18:3 n‐3), triggered by high concentrations of reactive oxygen species. In the current scenario of changing dietary patterns, additional information is needed on the concentrations of oxylipins in legumes and on the effect of sustained deficit irrigation on their concentration. The main objective of the work is to elucidate the phytoprostane and phytofuran profile (including eight and three compounds, respectively) of three Pisum sativum cultivars (“mangetout” (ssp. arvense), “BGE‐033620,” and “Lincoln”) and Phaseolus vulgaris (French bean cv. “Helda”), to unravel the oxidative response of these crops to sustained irrigation deficit in terms of oxidative stress, as well as in their importance as healthy dietary sources of new bioactive compounds. Phytoprostanes and phytofurans vary between varieties and species, with 9‐F₁ₜ‐PhytoP and ent‐16‐(RS)‐13‐epi‐ST‐Δ¹⁴‐9‐PhytoF being the most abundant. The level of phytoprostanes and phytofurans is also determined in sustained deficit irrigation (50% water needed), revealing modifications of their profile and concentration. In conclusion, bioactive phytoprostanes and phytofurans are present in legumes in high concentrations, being further modified by abiotic stress growing conditions, highlighting the importance of this plant food as a dietary source of these bioactive molecules. Practical Applications: This work is of high relevance from the lipidomic point of view, given that phytoprostanes and phytofurans have been promoted as new bioactive secondary metabolites due to their structural analogy with mammal oxylipins. These compounds can be further postulated as possible markers for the monitoring of the physiological status of legume plants under different agronomical conditions. The results obtained can contribute to the successful development of future research in the field of plant physiology and nutrition, significantly contributing to the advance of the current knowledge on the biological role of phytoprostanes and phytofurans in plants and complex biological systems. Species‐dependent modification of phytoprostanes and phytofurans by deficit irrigation in French‐bean, pea, and mangetout.

Published
2019
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49. Impact of Flavonols on Cardiometabolic Biomarkers: A Meta-Analysis of Randomized Controlled Human Trials to Explore the Role of Inter-Individual Variability

Author

Regina, Menezes, Ana, Rodriguez-Mateos, Antonia, Kaltsatou, Antonio, González-Sarrías, Arno, Greyling, Christoforos, Giannaki, Cristina, Andres-Lacueva, Dragan, Milenkovic, Eileen R, Gibney, Julie, Dumont, Manuel, Schär, Mar, Garcia-Aloy, Susana Alejandra, Palma-Duran, Tatjana, Ruskovska, Viktorija, Maksimova, Emilie, Combet, Paula, Pinto, Molecular Nutrition and Health Laboratory, Instituto de Technologia Quimica e Biologica, Division of Diabetes and Nutritional Sciences, Faculty of Life Sciences and Medicine, King‘s College London, FAME Laboratory, School of Exercise Science, University of Thessaly [Volos] (UTH), Centro de Edafologia y Biologia Aplicada del Segura, Unilever Research and Development, Université de Nicosie, Biomarkers and Nutrimetabolomic Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, University of Barcelona, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, University College Dublin [Dublin] (UCD), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement (Inserm U1167 - RID-AGE - Institut Pasteur), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Department of Food and Nutritional Sciences, University of Reading (UOR), Biomarkers and Nutrimetabolomic Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Science, Human Nutrition, University of Glasgow, University Goce Delcev (UGD), Department of Food Technology, Biotechnology and Nutrition, Insituto Politécnico de Santarém, Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), ProdInra, Archive Ouverte, and Clermont Université-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Recherche Agronomique (INRA)

Subjects
Adult, Male, Asia, flavonol, Flavonols, Blood Pressure, flavanoïde, Review, Interindividual variability, quercetin, systematic review, Risk Factors, cardiovascular disease, maladie cardiovasculaire, méta analyse, Food and Nutrition, Humans, étude clinique, glucose, Randomized Controlled Trials as Topic, interindividual variability, meta‐analysis, blood lipid, blood pressure, blood lipids, Cholesterol, HDL, Cholesterol, LDL, clinical study, Middle Aged, flavonols, Lipids, meta-analysis, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Santé publique et épidémiologie, Cholesterol, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Cardiovascular Diseases, Alimentation et Nutrition, Dietary Supplements, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Biomarkers, metaanalysis
Abstract

This article is based upon work from COST Action FA1403-POSITIVe "Interindividual variation in response to consumption of plant food bioactives and determinants involved" supported by COST (European Cooperation in Science and Technology, http://www.cost.eu/). The authors thank the financial support of the COST Action FA1403 "POSITIVe" to conduct two short-term scientific missions to P.P. and A.G.-S. at the University of Glasgow (E.C.) during which the data analysis was performed, and to M.G.-A at the University College Dublin (E.G.) during which the protocol was developed. A.G.-S. is holder of a "Juan de la Cierva" contract from MINECO (Spain). S.P.-D. is in receipt of a CONACyT scholarship. T.R. and V.M. are supported by the Fund for scientific research of Goce Delcev University, Stip. RM acknowledges iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is cofunded by Fundacao para a Ciencia e Tecnologia/Ministerio da Ciencia e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement. C.A.-L. thanks the grant PCIN-2014-133 (FoodBAll project) from the Spanish Ministry of Economy and Competitiveness (MINECO) within the Joint Programming Initiative Healthy Diet for Healthy Life (JPI-HDHL); Several epidemiological studies have linked flavonols with decreased risk of cardiovascular disease (CVD). However, some heterogeneity in the individual physiological responses to the consumption of these compounds has been identified. This meta‐analysis aimed to study the effect of flavonol supplementation on biomarkers of CVD risk such as, blood lipids, blood pressure and plasma glucose, as well as factors affecting their inter‐individual variability. Data from 18 human randomized controlled trials were pooled and the effect was estimated using fixed or random effects meta‐analysis model and reported as difference in means (DM). Variability in the response of blood lipids to supplementation with flavonols was assessed by stratifying various population subgroups: age, sex, country, and health status. Results showed significant reductions in total cholesterol (DM = −0.10 mmol/L; 95% CI: −0.20, −0.01), LDL cholesterol (DM = −0.14 mmol/L; Nutrients 2017, 9, 117 2 of 21 95% CI: −0.21, 0.07), and triacylglycerol (DM = −0.10 mmol/L; 95% CI: −0.18, 0.03), and a significant increase in HDL cholesterol (DM = 0.05 mmol/L; 95% CI: 0.02, 0.07). A significant reduction was also observed in fasting plasma glucose (DM = −0.18 mmol/L; 95%CI: −0.29, −0.08), and in blood pressure (SBP: DM = −4.84 mmHg; 95% CI: −5.64, −4.04; DBP: DM = −3.32 mmHg; 95% CI: -4.09, -2.55). Subgroup analysis showed a more pronounced effect of flavonol intake in participants from Asian countries and in participants with diagnosed disease or dyslipidemia, compared to healthy and normal baseline values. In conclusion, flavonol consumption improved biomarkers of CVD risk, however, country of origin and health status may influence the effect of flavonol intake on blood lipid levels

Published
2016
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50. Comparison between Arabidopsis and Rice for Main Pathways of K+ and Na+ Uptake by Roots

Author

Begoña Benito, Francisco Rubio, Manuel Nieves-Cordones, Vicente Martínez, Biochimie et Physiologie Moléculaire des Plantes (BPMP), Université de Montpellier (UM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Centro de Biotecnologia y Genomica de Plantas (CBGP), Departamento de Nutrición Vegetal, Centro de Edafologia y Biologia Aplicada del Segura, Rubio, Francisco, Ministerio de Economía y Competitividad (España), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)

Subjects
0106 biological sciences, 0301 basic medicine, roots, Sodium, Potassium, Arabidopsis, chemistry.chemical_element, Review, Plant Science, 01 natural sciences, 03 medical and health sciences, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, sodium, 2. Zero hunger, chemistry.chemical_classification, Membrane potential, Reactive oxygen species, uptake, rice, Vegetal Biology, biology, potassium, Transporter, 15. Life on land, biology.organism_classification, Apoplast, Salinity, 030104 developmental biology, absorption racinaire, chemistry, Biochemistry, root absorption, Biologie végétale, 010606 plant biology & botany
Abstract

K+ is an essential macronutrient for plants. It is acquired by specific uptake systems located in roots. Although the concentrations of K+ in the soil solution are widely variable, K+ nutrition is secured by uptake systems that exhibit different affinities for K+. Two main systems have been described for root K+ uptake in several species: the high-affinity HAK5-like transporter and the inward-rectifier AKT1-like channel. Other unidentified systems may be also involved in root K+ uptake, although they only seem to operate when K+ is not limiting. The use of knock-out lines has allowed demonstrating their role in root K+ uptake in Arabidopsis and rice. Plant adaptation to the different K+ supplies relies on the finely tuned regulation of these systems. Low K+-induced transcriptional up-regulation of the genes encoding HAK5-like transporters occurs through a signal cascade that includes changes in the membrane potential of root cells and increases in ethylene and reactive oxygen species concentrations. Activation of AKT1 channels occurs through phosphorylation by the CIPK23/CBL1 complex. Recently, activation of the Arabidopsis HAK5 by the same complex has been reported, pointing to CIPK23/CBL as a central regulator of the plant’s adaptation to low K+. Na+ is not an essential plant nutrient but it may be beneficial for some plants. At low concentrations, Na+ improves growth, especially under K+ deficiency. Thus, high-affinity Na+ uptake systems have been described that belong to the HKT and HAK families of transporters. At high concentrations, typical of saline environments, Na+ accumulates in plant tissues at high concentrations, producing alterations that include toxicity, water deficit and K+ deficiency. Data concerning pathways for Na+ uptake into roots under saline conditions are still scarce, although several possibilities have been proposed. The apoplast is a significant pathway for Na+ uptake in rice grown under salinity conditions, but in other plant species different mechanisms involving non-selective cation channels or transporters are under discussion., This work was funded by the Ministerio de Economía y Competitividad, Spain (grant number AGL2015-66434-R).

Published
2016
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