1. Na/K-ATPase: Their role in cell adhesion and migration in cancer
- Author
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Diogo Gomes Garcia, Bianca Portugal Tavares de Moraes, Cassiano Felippe Gonçalves-de-Albuquerque, Camila Ignácio da Silva, and Patrícia Burth
- Subjects
0301 basic medicine ,Programmed cell death ,Motility ,Biochemistry ,Cell membrane ,03 medical and health sciences ,Cell Movement ,Neoplasms ,Cell Adhesion ,medicine ,Humans ,Cell adhesion ,Cell Proliferation ,030102 biochemistry & molecular biology ,Chemistry ,Cell growth ,General Medicine ,respiratory system ,Neoplasm Proteins ,Cell biology ,Cell Adhesion Process ,030104 developmental biology ,medicine.anatomical_structure ,Cancer cell ,Sodium-Potassium-Exchanging ATPase ,Intracellular ,Signal Transduction - Abstract
Na/K-ATPase (NKA) is a p-type transmembrane enzyme formed by three different subunits (α, β, and γ gamma). Primarily responsible for transporting sodium and potassium through the cell membrane, it also plays a critical role in intracellular signaling. The activation of diverse intracellular pathways may trigger cell death, survival, or even cell proliferation. Changes in the NKA functions or expression in isoforms subunits impact pathological conditions, such as cancer. The NKA function affects cell adhesion, motility, and migration, which are different in the physiological and pathological states. All enzyme subunits take part in the cell adhesion process, with the β subunit being the most studied. Thus, herein we aim to highlight NKA' central role in cell adhesion, motility, and migration in cancer cells.
- Published
- 2021