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Na/K-ATPase: Their role in cell adhesion and migration in cancer
- Source :
- Biochimie. 185:1-8
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Na/K-ATPase (NKA) is a p-type transmembrane enzyme formed by three different subunits (α, β, and γ gamma). Primarily responsible for transporting sodium and potassium through the cell membrane, it also plays a critical role in intracellular signaling. The activation of diverse intracellular pathways may trigger cell death, survival, or even cell proliferation. Changes in the NKA functions or expression in isoforms subunits impact pathological conditions, such as cancer. The NKA function affects cell adhesion, motility, and migration, which are different in the physiological and pathological states. All enzyme subunits take part in the cell adhesion process, with the β subunit being the most studied. Thus, herein we aim to highlight NKA' central role in cell adhesion, motility, and migration in cancer cells.
- Subjects :
- 0301 basic medicine
Programmed cell death
Motility
Biochemistry
Cell membrane
03 medical and health sciences
Cell Movement
Neoplasms
Cell Adhesion
medicine
Humans
Cell adhesion
Cell Proliferation
030102 biochemistry & molecular biology
Chemistry
Cell growth
General Medicine
respiratory system
Neoplasm Proteins
Cell biology
Cell Adhesion Process
030104 developmental biology
medicine.anatomical_structure
Cancer cell
Sodium-Potassium-Exchanging ATPase
Intracellular
Signal Transduction
Subjects
Details
- ISSN :
- 03009084
- Volume :
- 185
- Database :
- OpenAIRE
- Journal :
- Biochimie
- Accession number :
- edsair.doi.dedup.....3ac6d1d7103fa9e9e685bae7f8f3c4fa