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46 results on '"Ceccarelli, Sara"'

8. XIX Congreso Nacional de Biotecnología y Bioingeniería CARACTERIZACIÓN DEL METABOLISMO DE ESPECIES TERRESTRES Y MARINAS DE MÉXICO

Author

Tamayo, Jorge Xool, Melgar, Alan Hernández, Romero, Erick Huerta, Salas, Nadia Caram, Villaseñor, Luz Garduño, Uribe, María Arteaga, Ceseña, Mario Salazar, Alonzo, Rodrigo Méndez, Ceccarelli, Sara Fadia, María, Lorena, Durán Riveroll, Edelweiss Rangel Montoya, Tripp, Jimena Carrillo, Hernández, Nahum Valente, Negrete, Olga Callejas, Pérez, Rosa Mouriño, Martínez, Rufina Hernández, Consarnau, Laura Gómez, Cruz, Miguel Cuevas, Gutiérrez-Grijalva, Erick P, Romero, Esperanza Martínez, Noyola, José Aguirre, Anidia Blanco Jarvio, Castillo, Patricia Valdespino, Winkler, Robert, Vázquez, Diana Franco, Flores, Laura Pérez, Martínez, Laila P Partida, Nuñez, Víctor M Flores, Bedoy, Rafael Bello, Sampedro, Esteban López, Tejera, Hilda León, Escandon, Magali Honey, Maturano, Luis Donis, Licona Cassani, Figueroa, Mario, Partida, Ernesto Beltrán, Reynoso, Hugo, Venegas, María, Reza, Mora, Martha Manzano, Espinosa, Roberto Arreguín, Silva, Daniela Trujillo, Gómez, Francisco Barona, Aboites, Hilda Ramos, Buenfil, Ingrid Rodríguez, Suárez, Juan Ramírez, Angulo, Laura Contreras, Álvarez, Lilian Palomino, Mozo, Nancy Suarez, Simoes, Nuno, Canche, Pedro Homá, Flota, Felipe Vázquez, Angulo, Marcela Gamboa, Castillo, Jaime Martínez, and Ulloa, Aldo Moreno

Published
2021
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9. The evolutionary history of colour polymorphism in Ischnura damselflies (Odonata: Coenagrionidae)

Author

Sánchez-Guillén, Rosa A., primary, Ceccarelli, Sara, additional, Villalobos, Fabricio, additional, Neupane, Suman, additional, Rivas-Torres, Anais, additional, Sanmartín-Villar, Iago, additional, Wellenreuther, Maren, additional, Bybee, Seth M., additional, Velásquez-Vélez, María I., additional, Realpe, Emilio, additional, Chávez-Ríos, Jesús R., additional, Dumont, Henri J., additional, and Cordero-Rivera, Adolfo, additional

Published
2020
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14. ROCK2 selective inhibitors for the treatment of fibrosis

Author

Guisot, Nicolas E S, Bunyard, Peter, Macfaul, Phillip, Offer, Emily P, Anderson, Katie, Best, Stuart A, Box, Matthew R, Ceccarelli, Sara, Cooke, Amy, Crossland, Charles, Douglas, Gayle E, Gignoux, Camille, Hawkins, Neil, Holland, Rebecca, Hunter, Alison, Jackson, Paula, Jones, Clifford D, Knowles, Rosie, Jean-Francois Margathe, Smith, Sam M, and Richard

Published
2019
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15. ROCK2 inhibitors for the treatment of NASH

Author

Guisot, Nicolas E S, Best, Stuart A, Macfaul, Phillip, Offer, Emily P, Box, Matthew R, Ceccarelli, Sara, Cooke, Amy, Crossland, Charles, Hawkins, Neil, Holland, Rebecca, Hunter, Alison, Knowles, Rosie, Smith, Sam, Bunyard, Peter, and Jones, Clifford D

Published
2019
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17. Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2

Author

Gnani, Daniela, Romito, Ilaria, Artuso, Simona, Chierici, Marco, De Stefanis, Cristiano, Panera, Nadia, Crudele, Annalisa, Ceccarelli, Sara, Carcarino, Elena, D'Oria, Valentina, Porru, Manuela, Giorda, Ezio, Ferrari, Karin, Miele, Luca, Villa, Erica, Balsano, Clara, Pasini, Diego, Furlanello, Cesare, Locatelli, Franco, Nobili, Valerio, Rota, Rossella, Leonetti, Carlo, Alisi, Anna, Miele, Luca (ORCID:0000-0003-3464-0068), Locatelli, Franco (ORCID:0000-0002-7976-3654), Gnani, Daniela, Romito, Ilaria, Artuso, Simona, Chierici, Marco, De Stefanis, Cristiano, Panera, Nadia, Crudele, Annalisa, Ceccarelli, Sara, Carcarino, Elena, D'Oria, Valentina, Porru, Manuela, Giorda, Ezio, Ferrari, Karin, Miele, Luca, Villa, Erica, Balsano, Clara, Pasini, Diego, Furlanello, Cesare, Locatelli, Franco, Nobili, Valerio, Rota, Rossella, Leonetti, Carlo, Alisi, Anna, Miele, Luca (ORCID:0000-0003-3464-0068), and Locatelli, Franco (ORCID:0000-0002-7976-3654)

Abstract

Hepatocellular carcinoma (HCC) is the most common type of liver cancer in humans. The focal adhesion tyrosine kinase (FAK) is often over-expressed in human HCC and FAK inhibition may reduce HCC cell invasiveness. However, the anti-oncogenic effect of FAK knockdown in HCC cells remains to be clarified. We found that FAK depletion in HCC cells reduced in vitro and in vivo tumorigenicity, by inducing G2/M arrest and apoptosis, decreasing anchorage-independent growth, and modulating the expression of several cancer-related genes. Among these genes, we showed that FAK silencing decreased transcription and nuclear localization of enhancer of zeste homolog 2 (EZH2) and its tri-methylation activity on lysine 27 of histone H3 (H3K27me3). Accordingly, FAK, EZH2 and H3K27me3 were concomitantly upregulated in human HCCs compared to non-tumor livers. In vitro experiments demonstrated that FAK affected EZH2 expression and function by modulating, at least in part, p53 and E2F2/3 transcriptional activity. Moreover, FAK silencing downregulated both EZH2 binding and histone H3K27me3 levels at the promoter of its target gene NOTCH2. Finally, we found that pharmacological inhibition of FAK activity resembled these effects although milder. In summary, we demonstrate that FAK depletion reduces HCC cell growth by affecting cancer-promoting genes including the pro-oncogene EZH2. Furthermore, we unveil a novel unprecedented FAK/EZH2 crosstalk in HCC cells, thus identifying a targetable network paving the way for new anticancer therapies.

Published
2017

19. Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2

Author

Gnani, Daniela, primary, Romito, Ilaria, additional, Artuso, Simona, additional, Chierici, Marco, additional, De Stefanis, Cristiano, additional, Panera, Nadia, additional, Crudele, Annalisa, additional, Ceccarelli, Sara, additional, Carcarino, Elena, additional, D’Oria, Valentina, additional, Porru, Manuela, additional, Giorda, Ezio, additional, Ferrari, Karin, additional, Miele, Luca, additional, Villa, Erica, additional, Balsano, Clara, additional, Pasini, Diego, additional, Furlanello, Cesare, additional, Locatelli, Franco, additional, Nobili, Valerio, additional, Rota, Rossella, additional, Leonetti, Carlo, additional, and Alisi, Anna, additional

Published
2017
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20. Human B‐cell memory is shaped by age‐ and tissue‐specific T‐independent and GC‐dependent events

Author

Aranburu, Alaitz, primary, Piano Mortari, Eva, additional, Baban, Anwar, additional, Giorda, Ezio, additional, Cascioli, Simona, additional, Marcellini, Valentina, additional, Scarsella, Marco, additional, Ceccarelli, Sara, additional, Corbelli, Sandro, additional, Cantarutti, Nicoletta, additional, De Vito, Rita, additional, Inserra, Alessandro, additional, Nicolosi, Luciana, additional, Lanfranchi, Arnalda, additional, Porta, Fulvio, additional, Cancrini, Caterina, additional, Finocchi, Andrea, additional, and Carsetti, Rita, additional

Published
2016
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22. Physiological and ultrastructural effects of acute ozone fumigation in the lichen <italic>Xanthoria parietina</italic>: the role of parietin and hydration state.

Author

Vannini, Andrea, Paoli, Luca, Ceccarelli, Sara, Sorbo, Sergio, Basile, Adriana, Carginale, Vincenzo, Nali, Cristina, Lorenzini, Giacomo, Pica, Mario, and Loppi, Stefano

Subjects
FUMIGATION, XANTHORIA, OZONE, PHOTOCHEMICAL smog, PHOTOSYNTHESIS, PHYSIOLOGY
Abstract

The physiological and ultrastructural effects induced by acute exposure to ozone (O3) were investigated in the lichen Xanthoria parietina. Our working hypothesis was that parietin content and hydration of the thalli may play a role in the modulation of the effects of O3 exposure. Four batches of X. parietina samples, dry and wet, with (P+) and without (P−) parietin, were fumigated for 1 h with 3 ppm O3. The effects of O3 were assessed immediately after the fumigation and after one week of recovery under controlled conditions. O3 fumigation caused physiological and ultrastructural impairment both to the photobiont and the mycobiont, irrespective if samples were fumigated wet or dry, and P+ or P−. However, one week after fumigation, a recovery was observed in P+ samples for the photobiont and in dry samples for the mycobiont. We suggest that the hydration state may play a major role in determining the severity of the damage, while the presence of parietin may promote the recovery. Our results provide physiological and ultrastructural basis to explain the ecological insensitivity of lichens to high environmental levels of ozone occurring during dry Mediterranean summers. [ABSTRACT FROM AUTHOR]

Published
2018
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23. LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease

Author

Ceccarelli, Sara, primary, Panera, Nadia, additional, Mina, Marco, additional, Gnani, Daniela, additional, De Stefanis, Cristiano, additional, Crudele, Annalisa, additional, Rychlicki, Chiara, additional, Petrini, Stefania, additional, Bruscalupi, Giovannella, additional, Agostinelli, Laura, additional, Stronati, Laura, additional, Cucchiara, Salvatore, additional, Musso, Giovanni, additional, Furlanello, Cesare, additional, Svegliati-Baroni, Gianluca, additional, Nobili, Valerio, additional, and Alisi, Anna, additional

Published
2015
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24. Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease

Author

Jahnel, Jörg, primary, Zöhrer, Evelyn, additional, Alisi, Anna, additional, Ferrari, Federica, additional, Ceccarelli, Sara, additional, De Vito, Rita, additional, Scharnagl, Hubert, additional, Stojakovic, Tatjana, additional, Fauler, Günter, additional, Trauner, Michael, additional, and Nobili, Valerio, additional

Published
2015
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26. Preliminary Results on Clinical Effects of Probiotic Lactobacillus salivarius LS01 in Children Affected by Atopic Dermatitis

Author

Niccoli, Antonio A., primary, Artesi, Anna L., additional, Candio, Francesco, additional, Ceccarelli, Sara, additional, Cozzali, Rita, additional, Ferraro, Luigi, additional, Fiumana, Donatella, additional, Mencacci, Manuela, additional, Morlupo, Maurizio, additional, Pazzelli, Paola, additional, Rossi, Laura, additional, Toscano, Marco, additional, and Drago, Lorenzo, additional

Published
2014
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27. Human B-cell memory is shaped by age- and tissue-specific T-independent and GC-dependent events.

Author

Aranburu, Alaitz, Piano Mortari, Eva, Baban, Anwar, Giorda, Ezio, Cascioli, Simona, Marcellini, Valentina, Scarsella, Marco, Ceccarelli, Sara, Corbelli, Sandro, Cantarutti, Nicoletta, Vito, Rita, Inserra, Alessandro, Nicolosi, Luciana, Lanfranchi, Arnalda, Porta, Fulvio, Cancrini, Caterina, Finocchi, Andrea, and Carsetti, Rita

Abstract

Switched and IgM memory B cells execute different and noninterchangeable functions. We studied memory B cells in children of different ages, in peripheral blood and spleen and compared them with those of children born asplenic or unable to build germinal centers. We show that, whereas switched memory B cells are mostly generated in the germinal centers at all ages, IgM memory B cells can be distinct in three types with different developmental history. Innate IgM memory B cells, the largest pool in infants, are generated in the spleen by a germinal center-independent mechanism. With age, if the spleen is present and germinal centers are functional, innate IgM memory B cells are remodelled and accumulate somatic mutations. The third type of IgM memory B cell is a by-product of the germinal center reaction. Our data suggest that the B-cell memory developmental program is implemented during the first 5-6 years of life. [ABSTRACT FROM AUTHOR]

Published
2017
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30. EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD

Author

Vella, Serena, Gnani, Daniela, Crudele, Annalisa, Ceccarelli, Sara, De Stefanis, Cristiano, Gaspari, Stefania, Nobili, Valerio, Locatelli, Franco, Marquez, Victor E, Rota, Rossella, Alisi, Anna, Locatelli, Franco (ORCID:0000-0002-7976-3654), Vella, Serena, Gnani, Daniela, Crudele, Annalisa, Ceccarelli, Sara, De Stefanis, Cristiano, Gaspari, Stefania, Nobili, Valerio, Locatelli, Franco, Marquez, Victor E, Rota, Rossella, Alisi, Anna, and Locatelli, Franco (ORCID:0000-0002-7976-3654)

Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent, chronic liver diseases, worldwide. It is a multifactorial disease caused by complex interactions between genetic, epigenetic and environmental factors. Recently, several microRNAs, some of which epigenetically regulated, have been found to be up- and/or down-regulated during NAFLD development. However, in NAFLD, the essential role of the Polycomb Group protein Enhancer of Zeste Homolog 2 (EZH2), which controls the epigenetic silencing of specific genes and/or microRNAs by trimethylating Lys27 on histone H3, still remains unknown. In this study, we demonstrate that the nuclear expression/activity of the EZH2 protein is down-regulated both in livers from NAFLD rats and in the free fatty acid-treated HepG2. The drop in EZH2 is inversely correlated with: (i) lipid accumulation; (ii) the expression of pro-inflammatory markers including TNF- and TGF-; and (iii) the expression of miR-200b and miR-155. Consistently, the pharmacological inhibition of EZH2 by 3-Deazaneplanocin A (DZNep) significantly reduces EZH2 expression/activity, while it increases lipid accumulation, inflammatory molecules and microRNAs. In conclusion, the results of this study suggest that the defective activity of EZH2 can enhance the NAFLD development by favouring steatosis and the de-repression of the inflammatory genes and that of specific microRNAs.

Published
2013

42. Preliminary Results on Clinical Effects of Probiotic Lactobacillus salivariusLS01 in Children Affected by Atopic Dermatitis

Author

Niccoli, Antonio A., Artesi, Anna L., Candio, Francesco, Ceccarelli, Sara, Cozzali, Rita, Ferraro, Luigi, Fiumana, Donatella, Mencacci, Manuela, Morlupo, Maurizio, Pazzelli, Paola, Rossi, Laura, Toscano, Marco, and Drago, Lorenzo

Abstract

The goal of this study was to evaluate the clinical efficacy of an intake of Lactobacillus salivariusLS01 (DSM 22775) for the treatment of atopic dermatitis (AD) in children.

Published
2014
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43. Physiological and ultrastructural effects of acute ozone fumigation in the lichen Xanthoria parietina: the role of parietin and hydration state

Author

Cristina Nali, Luca Paoli, Andrea Vannini, Sergio Sorbo, Vincenzo Carginale, Sara Ceccarelli, Stefano Loppi, Giacomo Lorenzini, Mario Pica, Adriana Basile, Vannini, Andrea, Paoli, Luca, Ceccarelli, Sara, Sorbo, Sergio, Basile, Adriana, Carginale, Vincenzo, Nali, Cristina, Lorenzini, Giacomo, Pica, Mario, and Loppi, Stefano

Subjects
0106 biological sciences, 0301 basic medicine, Emodin, Ozone, Lichens, Health, Toxicology and Mutagenesis, Fumigation, Air pollution, Parietin, Biology, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Xanthoria parietina, Ergosterol, Biomonitoring, Chlorophyll a fluorescence, Environmental Chemistry, Pollution, Ecotoxicology, Toxicology and Mutagenesis, Lichen, General Medicine, biology.organism_classification, Thallus, 030104 developmental biology, chemistry, Health, Environmental chemistry, Seasons, 010606 plant biology & botany
Abstract

The physiological and ultrastructural effects induced by acute exposure to ozone (O3) were investigated in the lichen Xanthoria parietina. Our working hypothesis was that parietin content and hydration of the thalli may play a role in the modulation of the effects of O3 exposure. Four batches of X. parietina samples, dry and wet, with (P+) and without (P−) parietin, were fumigated for 1 h with 3 ppm O3. The effects of O3 were assessed immediately after the fumigation and after one week of recovery under controlled conditions. O3 fumigation caused physiological and ultrastructural impairment both to the photobiont and the mycobiont, irrespective if samples were fumigated wet or dry, and P+ or P−. However, one week after fumigation, a recovery was observed in P+ samples for the photobiont and in dry samples for the mycobiont. We suggest that the hydration state may play a major role in determining the severity of the damage, while the presence of parietin may promote the recovery. Our results provide physiological and ultrastructural basis to explain the ecological insensitivity of lichens to high environmental levels of ozone occurring during dry Mediterranean summers.

Published
2018

44. MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease.

Author

Panera N, Gnani D, Crudele A, Ceccarelli S, Nobili V, and Alisi A

Subjects
Animals, Epigenesis, Genetic, Gene Expression Regulation, Genetic Markers, Genetic Predisposition to Disease, Humans, Liver pathology, Liver Cirrhosis epidemiology, Liver Cirrhosis genetics, Liver Cirrhosis metabolism, MicroRNAs metabolism, Non-alcoholic Fatty Liver Disease diagnosis, Non-alcoholic Fatty Liver Disease epidemiology, Non-alcoholic Fatty Liver Disease metabolism, Phenotype, Prognosis, Risk Assessment, Risk Factors, Signal Transduction, Liver metabolism, MicroRNAs genetics, Non-alcoholic Fatty Liver Disease genetics
Abstract

Non-alcoholic fatty liver disease (NAFLD) is a multi-faceted condition including simple steatosis alone or associated with inflammation and ballooning (non-alcoholic steatohepatitis) and eventually fibrosis. The NAFLD incidence has increased over the last twenty years becoming the most frequent chronic liver disease in industrialized countries. Obesity, visceral adiposity, insulin resistance, and many other disorders that characterize metabolic syndrome are the major predisposing risk factors for NAFLD. Furthermore, different factors, including genetic background, epigenetic mechanisms and environmental factors, such as diet and physical exercise, contribute to NAFLD development and progression. Several lines of evidence demonstrate that specific microRNAs expression profiles are strongly associated with several pathological conditions including NAFLD. In NAFLD, microRNA deregulation in response to intrinsic genetic or epigenetic factors or environmental factors contributes to metabolic dysfunction. In this review we focused on microRNAs role both as controlled and controllers molecules in NAFLD development and/or their eventual value as non-invasive biomarkers of disease.

Published
2014
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45. Rare lymphoid malignancies of the breast: report of two cases illustrating potential diagnostic techniques.

Author

Schillaci O, Travascio L, Lacanfora A, Ceccarelli S, and Simonetti G

Subjects
Aged, Breast Neoplasms pathology, Female, Fluorodeoxyglucose F18, Humans, Lymphoma, B-Cell pathology, Lymphoma, Non-Hodgkin pathology, Predictive Value of Tests, Radiopharmaceuticals, Sensitivity and Specificity, Breast Neoplasms diagnosis, Lymphoma, B-Cell diagnosis, Lymphoma, Non-Hodgkin diagnosis, Mammography, Multimodal Imaging, Positron-Emission Tomography, Tomography, X-Ray Computed, Ultrasonography, Mammary
Abstract

Two cases of lymphoid malignancy involving the breast are herein presented. Both patients were admitted with a palpable breast mass. Ultrasound demonstrated hypoechoic, ill-defined lesions of the breast in both patients; mammogram also showed spiculated breast densities. Both patients underwent core biopsy, which revealed lymphomatous cells. Total-body evaluation was also performed by computed tomography and positron emission tomography/computed tomography revealing no other fluorodeoxyglucose-avid foci in the first case and supra and subdiaphragmatic disease in the second one.

Published
2012
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46. Markers of activated inflammatory cells correlate with severity of liver damage in children with nonalcoholic fatty liver disease.

Author

De Vito R, Alisi A, Masotti A, Ceccarelli S, Panera N, Citti A, Salata M, Valenti L, Feldstein AE, and Nobili V

Subjects
Adolescent, Antigens, CD analysis, Antigens, Differentiation, Myelomonocytic analysis, Biomarkers, CD3 Complex analysis, Child, Fatty Liver pathology, Female, Humans, Inflammation, Leukocyte Common Antigens analysis, Liver Cirrhosis pathology, Male, Natural Killer T-Cells immunology, Non-alcoholic Fatty Liver Disease, Obesity, Receptors, Cell Surface analysis, Fatty Liver immunology, Liver immunology, Liver pathology
Abstract

Concomitantly to the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become the leading cause of liver disease in children. NAFLD encompasses a spectrum of histological damage ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), with possible progression to cirrhosis. There is growing evidence that the immune system plays a pivotal role in the initiation and progression to NASH but the cellular nature of the hepatic inflammation is still unknown. The present study includes 34 children with biopsy-proven NAFLD. Liver damage was evaluated by the NAFLD activity score (NAS), and the inflammatory infiltrate was characterized by immunohistochemistry for CD45, CD3 and CD163 which are markers of leukocytes, T cells and activated Kupffer cells/macrophages, respectively. Our results have shown that CD45+ (P<0.0001) and CD163+ (P<0.0001) cells were markedly increased in children with severe histological activity (NAS≥5) compared to children with lower activity (NAS<5), whereas CD3+ cells were significantly lower (P<0.01) in children with severe histological activity. There was a significant association between the numbers of CD45+, CD3+ and CD163+ cells, regarding both the portal tract and liver lobule, and the severity of steatosis, ballooning and fibrosis (P<0.01). These data suggest that the severity and composition of the inflammatory infiltrate correlate with steatosis and the severity of disease in children with NAFLD. Moreover, a decrease in CD3+ cells may be involved in the pathogenesis of liver damage. Future studies should evaluate whether it can predict the progression of liver disease independently of established histological scores.

Published
2012
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