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MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2014 Nov 07; Vol. 20 (41), pp. 15079-86. - Publication Year :
- 2014
-
Abstract
- Non-alcoholic fatty liver disease (NAFLD) is a multi-faceted condition including simple steatosis alone or associated with inflammation and ballooning (non-alcoholic steatohepatitis) and eventually fibrosis. The NAFLD incidence has increased over the last twenty years becoming the most frequent chronic liver disease in industrialized countries. Obesity, visceral adiposity, insulin resistance, and many other disorders that characterize metabolic syndrome are the major predisposing risk factors for NAFLD. Furthermore, different factors, including genetic background, epigenetic mechanisms and environmental factors, such as diet and physical exercise, contribute to NAFLD development and progression. Several lines of evidence demonstrate that specific microRNAs expression profiles are strongly associated with several pathological conditions including NAFLD. In NAFLD, microRNA deregulation in response to intrinsic genetic or epigenetic factors or environmental factors contributes to metabolic dysfunction. In this review we focused on microRNAs role both as controlled and controllers molecules in NAFLD development and/or their eventual value as non-invasive biomarkers of disease.
- Subjects :
- Animals
Epigenesis, Genetic
Gene Expression Regulation
Genetic Markers
Genetic Predisposition to Disease
Humans
Liver pathology
Liver Cirrhosis epidemiology
Liver Cirrhosis genetics
Liver Cirrhosis metabolism
MicroRNAs metabolism
Non-alcoholic Fatty Liver Disease diagnosis
Non-alcoholic Fatty Liver Disease epidemiology
Non-alcoholic Fatty Liver Disease metabolism
Phenotype
Prognosis
Risk Assessment
Risk Factors
Signal Transduction
Liver metabolism
MicroRNAs genetics
Non-alcoholic Fatty Liver Disease genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 20
- Issue :
- 41
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25386056
- Full Text :
- https://doi.org/10.3748/wjg.v20.i41.15079