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Markers of activated inflammatory cells correlate with severity of liver damage in children with nonalcoholic fatty liver disease.
- Source :
-
International journal of molecular medicine [Int J Mol Med] 2012 Jul; Vol. 30 (1), pp. 49-56. Date of Electronic Publication: 2012 Apr 10. - Publication Year :
- 2012
-
Abstract
- Concomitantly to the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become the leading cause of liver disease in children. NAFLD encompasses a spectrum of histological damage ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), with possible progression to cirrhosis. There is growing evidence that the immune system plays a pivotal role in the initiation and progression to NASH but the cellular nature of the hepatic inflammation is still unknown. The present study includes 34 children with biopsy-proven NAFLD. Liver damage was evaluated by the NAFLD activity score (NAS), and the inflammatory infiltrate was characterized by immunohistochemistry for CD45, CD3 and CD163 which are markers of leukocytes, T cells and activated Kupffer cells/macrophages, respectively. Our results have shown that CD45+ (P<0.0001) and CD163+ (P<0.0001) cells were markedly increased in children with severe histological activity (NASā„5) compared to children with lower activity (NAS<5), whereas CD3+ cells were significantly lower (P<0.01) in children with severe histological activity. There was a significant association between the numbers of CD45+, CD3+ and CD163+ cells, regarding both the portal tract and liver lobule, and the severity of steatosis, ballooning and fibrosis (P<0.01). These data suggest that the severity and composition of the inflammatory infiltrate correlate with steatosis and the severity of disease in children with NAFLD. Moreover, a decrease in CD3+ cells may be involved in the pathogenesis of liver damage. Future studies should evaluate whether it can predict the progression of liver disease independently of established histological scores.
- Subjects :
- Adolescent
Antigens, CD analysis
Antigens, Differentiation, Myelomonocytic analysis
Biomarkers
CD3 Complex analysis
Child
Fatty Liver pathology
Female
Humans
Inflammation
Leukocyte Common Antigens analysis
Liver Cirrhosis pathology
Male
Natural Killer T-Cells immunology
Non-alcoholic Fatty Liver Disease
Obesity
Receptors, Cell Surface analysis
Fatty Liver immunology
Liver immunology
Liver pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1791-244X
- Volume :
- 30
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22505182
- Full Text :
- https://doi.org/10.3892/ijmm.2012.965