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This review provides an in-depth examination of recent progress in the development of chemosensors, with a particular emphasis on colorimetric and fluorescent probes. It systematically explores various sensing mechanisms, including metal-to-ligand charge transfer (MLCT), ligand-to-metal charge transfer (LMCT), photoinduced electron transfer (PET), intramolecular charge transfer (ICT), and fluorescence resonance energy transfer (FRET), and elucidates the mechanism of action for cation and anion chemosensors. Special attention is given to phenothiazine-based fluorescence probes, highlighting their exceptional sensitivity and rapid detection abilities for a broad spectrum of analytes, including cations, anions, and small molecules. Phenothiazine chemosensors have emerged as versatile tools widely employed in a multitude of applications, spanning environmental and biomedical fields. Furthermore, it addresses existing challenges and offers insights into future research directions, aiming to facilitate the continued advancement of phenothiazine-based fluorescent probes., (© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

The rapid detection of contaminants in water resources is vital for safeguarding the environment, where the use of eco-friendly materials for water monitoring technologies has become increasingly prioritized. In this context, the role of biocomposites in the development of a SERS sensor is reported in this study. Grafted chitosan was employed as a matrix support for Ag nanoparticles (NPs) for the surface-enhanced Raman spectroscopy (SERS). Chitosan (CS) was decorated with thiol and carboxylic acid groups by incorporating S-acetyl mercaptosuccinic anhydride (SAMSA) to yield CS-SAMSA. Then, Ag NPs were immobilized onto the CS-SAMSA (Ag@CS-SAMSA) and characterized by spectral methods (IR, Raman, NIR, solid state 13 C NMR with CP-MAS, XPS, and TEM). Ag@CS-SAMSA was evaluated as a substrate for SERS, where methylene blue (MB) was used as a model dye adsorbate. The Ag@CS-SAMSA sensor demonstrated a high sensitivity (with an enhancement factor ca. 10 8 ) and reusability over three cycles, with acceptable reproducibility and storage stability. The Raman imaging revealed a large SERS effect, whereas the MB detection varied from 1-100 μM. The limits of detection (LOD) and quantitation (LOQ) of the biocomposite sensor were characterized, revealing properties that rival current state-of-the-art systems. The dye adsorption profiles were studied via SERS by fitting the isotherm results with the Hill model to yield the ΔG° ads for the adsorption process. This research demonstrates a sustainable dual-function biocomposite with tailored adsorption and sensing properties suitable for potential utility in advanced water treatment technology and environmental monitoring applications.

Nutrient availability in hydroponic solutions must be accurately monitored to maintain crop productivity; however, few cost-effective, accurate, real-time, and long-term monitoring technologies have been developed. In this study, we describe the development and application of cation-/anion-exchange chromatography with a neutral eluent (20-mmol/L sodium formate, pH 7.87) for the simultaneous separation (within 50 min) of ionic nutrients, including K+, NH4+, NO2-, NO3-, and phosphate ion, in a hydroponic fertilizer solution. Using the neutral eluent avoided degradation of the separation column during precipitation of metal ion species, such as hydroxides, with an alkaline eluent and oxidation of NO2- to NO3- with an acidic eluent. The suitability of the current method for monitoring ionic components in a hydroponic fertilizer solution was confirmed. Based on our data, we propose a controlled fertilizer strategy to optimize fertilizer consumption and reduce the chemical load of drained fertilizer solutions., (© The Author(s) 2024. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.)

In this study, we introduce a novel approach for the analysis of salivary ions using capillary electrophoresis (CE) with a triple-layer coated capillary. The capillary is sequentially coated with cationic silylating reagents, poly(vinylsulfonate), and polybrene to form a custom designed surface that effectively inhibits adsorption of protein matrix on the capillary inner wall and allows for reproducible ion analysis. For the CE with capacitively coupled contactless conductivity detection, we used suitable background electrolytes (BGEs) for salivary ion analysis. Anions were separated using a mixture of 2-(N-morpholino)ethanesulfonic acid and l-arginine, and cations were separated using that with 18-crown-6. This setup enabled rapid separation, within 4 min, together with sensitive detection. We quantified nine common anions and five cations typically found in saliva samples using this CE method, both before and after a cold pressure test (CPT, a standard stress test). The CE system demonstrated consistent ion separation across 30 consecutive measurements without requiring capillary replacement. Notably, the salivary ion balance remained predominantly anion-rich, regardless of the CPT. Cold water exposure induced greater variation in the total anion concentration than in the total cation concentration. Further analysis using multiple regression analysis revealed strong relationships between nitrate and nitrite, formate and phosphate, and potassium and nitrate, before and after the CPT. Notably, potassium and nitrate ions exhibited variations in response to stress. These results provided a method for assessing salivary ion composition and insights into the potential of salivary ions as biomarkers for stress., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Masanobu Mori reports financial support was provided by Japan Society for the Promotion of Science. Masanobu Mori reports a relationship with Japan Society for the Promotion of Science that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)

Ionic valency influences oral processing by changing salivary behavior and merits more attention since little is known. In this study, the influence of three ionic valences (monovalent, divalent and trivalent), ionic strength and epigallocatechin gallate (EGCG) on lubricating properties of saliva were investigated. Tribological measurements were used to characterize the lubrication response of KCl, MgCl 2 , FeCl 3 , and AlCl 3 in combination with EGCG to the ex vivo salivary pellicle. KCl at 150 mM ionic strength provided extra lubrication via hydration lubrication. Contrarily, trivalent salts aggregated together with the salivary mucins via ionic cross-link interactions, which led to a decrease in salivary lubrication. FeCl 3 and AlCl 3 affected the salivary lubrication differently, which was attributed to changes in the pH. Finally, in presence of EGCG, FeCl 3 interacted with EGCG via chelating interactions, preventing salivary protein aggregation. This resulted in less desorption of the salivary film, retaining the lubrication ability of salivary proteins., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Water sources in mining areas do not retain their natural quality due to the influence of mine drainage. Water quality test was through hydrochemical analysis, speciation modeling, and saturation indices. Water samples were analyzed for pH, conductivity, nitrate, phosphate, sulfate, chlorite, sodium, magnesium, calcium, turbidity, total hardness, lead, zinc, iron, copper, cadmium, manganese, nickel, and chromium. Mean values of turbidity (0.13 mg/L), lead (0.01 mg/L), and cadmium (6.40 mg/L) exceeded their permissible values for potable water. Multivariate statistical analysis shows geogenic and anthropogenic sources of chemical species. Chemical speciation shows that the cations exist mostly in their soluble and mobile forms as free ions. Water quality index of 35-45.5 shows good water for drinking, irrigation, and industrial uses. The values of 63.8-68.8 and 103-121 reflect suitable water for industrial and irrigation uses. The research is integrated and credible in predicting groundwater pollutants to solve water pollution problems. PRACTITIONER POINTS: The mean value of turbidity, Pb, and Cd exceeded the WHO/NSDWQ standards for potable water. Correlation and principal component analyses show that the chemical species are from both geogenic and anthropogenic sources. Chemical speciation shows that the cations exist in their soluble and mobile forms as free ions except Cr. Saturation indices show that the minerals anhydrite, anglesite, vivianite, langite, larnakite, melanterite, and mirabilite are undersaturated in the water sources. Water quality index shows that the water is more suitable for irrigation than drinking and industrial uses., (© 2023 Water Environment Federation.)

In the present study, a homemade mixed-mode ion-exchange sorbent based on silica with embedded graphene microparticles is applied for the selective extraction of 2-aminobenzothiazole (NH 2 BT) followed by determination through liquid chromatography coupled to high-resolution mass spectrometry. The sorbent was evaluated for the solid-phase extraction of NH 2 BT from environmental water samples (river, effluent wastewater, and influent wastewater), and NH 2 BT was strongly retained through the selective cation-exchange interactions. Therefore, the inclusion of a clean-up step of 7 mL of methanol provided good selectivity for the extraction of NH 2 BT. The apparent recoveries obtained for environmental water samples ranged from 62 to 69% and the matrix effect from -1 to -14%. The sorbent was also evaluated in the clean-up step of the organic extract for the extraction of NH 2 BT from organic extracts of indoor dust samples (10 mL of ethyl acetate from pressurized liquid extraction) and fish (10 mL of acetonitrile from QuEChERS extraction). The organic extracts were acidified (adding a 0.1% of formic acid) to promote the cation-exchange interactions between the sorbent and the analyte. The apparent recoveries for fish samples ranged from 22 to 36% depending on the species. In the case of indoor dust samples, the recovery was 41%. It should be highlighted the low matrix effect encountered in such complex samples, with values ranging from -7 to 5% for fish and dust samples. Finally, various samples were analyzed. The concentration in river samples ranged from 31 to 136 ng/L; in effluent wastewater samples, from 55 to 191 ng/L; in influent wastewater samples, from 131 to 549 ng/L; in fish samples, from 14 to 57 ng/g dried weight; and in indoor dust samples, from 

Water contamination undermines human survival and economic growth. Water resource protection and management require knowledge of water hydrochemistry and drinking water quality characteristics, mechanisms, and factors. Self-organizing maps (SOM) have been developed using quantization and topographic error approaches to cluster hydrochemistry datasets. The Piper diagram, saturation index (SI), and cation exchange method were used to determine the driving mechanism of hydrochemistry in both surface and groundwater, while the Gibbs diagram was used for surface water. In addition, redundancy analysis (RDA) and a generalized linear model (GLM) were used to determine the key drinking water quality parameters in the study area. Additionally, the study aimed to utilize Explainable Artificial Intelligence (XAI) techniques to gain insights into the relative importance and impact of different parameters on the entropy water quality index (EWQI). The SOM results showed that thirty neurons generated the hydrochemical properties of water and were organized into four clusters. The Piper diagram showed that the primary hydrochemical facies were HCO 3 - -Ca 2+ (cluster 4), Cl---Na + (all clusters), and mixed (clusters 1 and 4). Results from SI and cation exchange show that demineralization and ion exchange are the driving mechanisms of water hydrochemistry. About 45 % of the studied samples are classified as "medium quality"," that could be suitable as drinking water with further refinement. Cl - may pose increased non-carcinogenic risk to adults, with children at double risk. Cluster 4 water is low-risk, supporting EWQI findings. The RDA and GLM observations agree in that Ca 2+ , Mg 2+ , Na + , Cl - and HCO 3 - all have a positive and significant effect on EWQI, with the exception of K + . TDS, EC, Na+, and Ca 2+ have been identified as influencing factors based on bagging-based XAI analysis at global and local levels. The analysis also addressed the importance of SO 4 , HCO 3 , Cl, Mg 2+ , K+, and pH at specific locations., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier B.V.)

The water environment of large reservoirs is fragility due to effects from hydrological regulation of damming and anthropogenic inputs. As a critical path to quantify the natural chemical weathering and assess environmental risks, solute chemistry of river has been widely focused on. However, the complexed hydrological conditions of large reservoir affect the chemical compositions, and the significance of solute vertical geochemistry as an indicator of chemical weathering and water quality health remains explore. Therefore, the Three Gorges Reservoir (TGR) was selected as a typical study area, which is the world's largest hydropower project and subject to frequent water quality problems. Then, the chemical compositions in stratified water were determined. Ca 2+ (52.8 ± 4.3 mg/L) and HCO 3 - (180.9 ± 8.9 mg/L) were the most abundant ions among cations and anions, respectively. Incremental mean concentration of total major ions followed with the increase of riverine depth and flow direction. An improved inversion model was used to quantify the source contribution, which weathering of dolomite (34%) and calcite (38%) contributed the most to total cations, and the influences of agriculture and sewage discharge were limited. Additional contributions of evaporite and pyrite oxidation were found in analysis of deeper water samples, which also results in 2%-67% difference in estimated CO 2 release flux using data from different depth, indicating additional information about sulfuric acid driven weathering was contained. Finally, the water quality of the reservoir was assessed for irrigation and non-carcinogenic risks. Results showed the stratified water of TGR can be used as a good water source of irrigation. However, NO 3 - (5.1 ± 1.1 mg/L) may have a potential non-carcinogenic risk to children, especially in surface water. To sum up, this study provided an indispensable supplement to the water chemistry archives in the TGR basin, serving as theoretical references for environmental management of large reservoirs., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Stormwater infiltration basins have been used extensively around the world to restore urban hydrology towards more natural flow and water quality regimes. There is, however, significant uncertainty in the fate of infiltrated water and accompanying contaminants that depends on multiple factors including media characteristics, interactions with downslope vegetation, legacy contaminants, and presence of underground infrastructure. Understanding the influence of such factors is thus central to the design and siting of infiltration basins. An extensive field program was established to collect monthly data on ground water quality, including nutrients and major ion concentrations, in a bore network downstream of a stormwater infiltration basin in Victoria, Australia. The groundwater samples were analysed for temperature, pH, EC, turbidity, major ions (Na + , Ca 2+ , K + , Mg 2+ , Cl - , SO 4 2- , NO 3 - , CO 3 2- , HCO 3 - ), NOx and heavy metals. The collected data were used to understand the origin and fate of water and solutes in the subsurface and their interactions with the soil matrix. The results revealed that Ca-HCO 3 , Na-Cl water types predominate in the study area, grouped in 3 clusters; shallow fresh groundwater in the vicinity of the basin (near basin), deep saline groundwater further downstream of the basin (near-stream) and a mid-section where rock-water interaction (Na-HCO 3 water) through cation exchange control the chemistry of groundwater. The results also suggest that as the water moves downstream of the basin, it experiences significant evapotranspiration and concentration due to the presence of deep-rooted vegetation. The results suggest that while infiltration basins can remove infiltrated contaminants, the infiltrated stormwater can mobilise legacy contaminants such as nitrate. Overall, the efficacy of infiltration basins in urban regions depends substantially on the downstream vegetation, urban underground infrastructure and the presence of legacy contaminants in the soils. These all need to be considered in the design of stormwater infiltration basins., (© 2023. The Author(s).)

Toxic cations, including heavy metals, pose significant environmental and health risks, necessitating the development of reliable detection methods. This review investigates the techniques and approaches used to strengthen the sensitivity and selectivity of Schiff base fluorescent chemosensors designed specifically to detect toxic and heavy metal cations. The paper explores a range of strategies, including functional group variations, structural modifications, and the integration of nanomaterials or auxiliary receptors, to amplify the efficiency of these chemosensors. By improving selectivity towards targeted cations and achieving heightened sensitivity and detection limits, consequently, these strategies contribute to the advancement of accurate and efficient detection methods while increasing the range of end-use applications. The findings discussed in this review offer valuable insights into the potential of leveraging Schiff base fluorescent chemosensors for the accurate and reliable detection and monitoring of heavy metal cations in various fields, including environmental monitoring, biomedical research, and industrial safety.

Air pollution is a global issue that often transcends national borders, leading to disputes over environmental concerns and climate-mitigation responsibilities. Between March and July 2020, we collected aerosol samples in Jimunai, a town in western China neighboring Kazakhstan, to assess transboundary air pollution in the region. Our analysis focused on major water-soluble inorganic ions (WSIs), with Ca 2+ and SO 4 2- accounting for almost 60% of the total ion loading. The ratio of cations to anions was greater than one (1.33 ± 0.27), indicating alkaline aerosols during the sampling period. Our results suggest that the pollutants measured were primarily sourced from Kazakhstan, as demonstrated by local meteorological data, air-mass trajectory analysis, and pollutant emission inventories in Kazakhstan. Correlation and primary component analysis indicated that NH 4 + played an important role in neutralizing NO 3 - and SO 4 2- , while Cl - was significantly depleted by the probable reaction HNO 3 ↑ + NaCl = HCl↑ + NaNO 3 . These findings highlight the need for continued monitoring and regulation of air pollution sources in the region to address transboundary air pollution., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Fluoride (F - ) enrichment in groundwater of the lower Gangetic plain in West Bengal, India is a major concern. Fluoride contamination and its toxicity were reported earlier in this region; however, limited evidence was available on the precise site of contamination, hydro-geochemical attributions of F - mobilization and probabilistic health risk caused by fluoridated groundwater. The present study addresses the research gap by exploring the spatial distribution and physico-chemical parameters of fluoridated groundwater along with the depth-wise sedimental distribution of F - . Approximately, 10 % of the groundwater samples (n = 824) exhibited high F -  ≥ 1.5 mg/l from 5, out of 19 gram-panchayats and Baruipur municipality area and the maximum F - was observed in Dhapdhapi-II gram-panchayat with 43.7 % of samples showed ≥1.5 mg/l (n = 167). The distribution patterns of cations and anions in fluoridated groundwater were Na +  > Ca 2+  > Mg 2+  > Fe > K + and Cl -  > HCO 3 -  > SO 4 2-  > CO 3 2-  > NO 3 -  > F - . Different statistical models like Piper and Gibbs diagram, Chloro Alkaline plot, Saturation index were applied to better understand the hydro-geochemical characteristics for F - leaching in groundwater. Fluoridated groundwater is of Na-Cl type which implies strong saline character. The intermediate zone between evaporation and rock dominance area controls F - mobilization along with ion-exchange process occurring between groundwater and host silicate mineral. Furthermore, saturation index proves geogenic activities related to groundwater F - mobilization. All cations present in sediment samples are closely interlinked with F - in the depth range of 0-18.3 m. Mineralogical analyses revealed that muscovite is the most responsible mineral for F - mobilization. The probabilistic health risk assessment disclosed severe health hazard in the order of infants > adults > children > teenagers through F - tainted groundwater. At P95 percentile dose, all the studied age groups showed THQ >1 from Dhapdhapi-II gram-panchayat. Supply of F - safe drinking water is required through reliable water supply strategies in the studied area., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

In this study, a new tetraphenylethene derivative bearing triazole and pyridine moieties (TPE-TAP) was synthesized using click chemistry. The fluorescence sensing properties of TPE-TAP were investigated in almost 100% aqueous media. For this purpose, first of all, structural characterization of the newly synthesized compound TPE-TAP was performed by NMR and HRMS analyses. Then, the optical behavior of TPE-TAP was investigated in different ratios of a THF-water mixture (0-98%). The obtained results showed that the best fluorescence for TPE-TAP was observed in the presence of 98% water in the medium. Then, the ion selectivity of TPE-TAP was determined using 19 different cations in the THF-water medium (2 : 98 v/v%). It was observed that among the cations studied, only Fe 3+ quenched the fluorescence of TPE-TAP. The detection limit and binding constant values of TPE-TAP for Fe 3+ were calculated as 1.3 μM and 26.65 M -2 , respectively, from the graph results of the decrease in the fluorescence intensity of TPE-TAP in the presence of Fe 3+ at different concentrations. In addition, the study investigating the selectivity of TPE-TAP in the presence of 18 cations other than Fe 3+ showed that none of the studied cations interfered with Fe 3+ . Practical application of TPE-TAP was also carried out using a commercial iron drug. All results showed that TPE-TAP is a fluorometric sensor highly selective, sensitive, and suitable for practical application for Fe 3+ ions in aqueous medium.

Groundwater is a valuable resource for developmental activities, and its demand is growing as surface water becoming scarce. Groundwater demand is increasing, resulting in reduction in water level and deterioration in water quality. A total of 156 groundwater samples were taken from Gaya, a district in Bihar (India), to check the safety of drinking water. The quality of groundwater was assessed using a water quality index (WQI). Analysed samples were assessed using a variety of physicochemical characteristics, and statistical methods principal component analysis (PCA) and cluster analysis (CA) were used as they are effective and efficient. As per the Gibbs, plot majority of the sample falls in the rock-water interaction and some evaporation dominance field. The domination of major cation in the order of Ca 2+  > Mg 2+  > Na + and the major anions followed the order of HCO 3 -  > [Formula: see text]>[Formula: see text]>[Formula: see text]>[Formula: see text]. The KMO's sample adequacy value of 0.703 and the significance level of Bartlett's test of sphericity (0.0001) were indicating that PCA may be implemented. Using the PCA, the three components recovered explained 69.58% of the total variation. Cluster analysis classified the groundwater sample into three cluster based on the similarities among chemical parameters involved in groundwater quality. HCA exhibit less, intermediate, and heavily mineralized groundwater characteristics of groups I, II, and III, respectively. The major parameters affecting the water quality in the study region are TDS, Ca 2+ , Mg 2+ , HCO 3 - , [Formula: see text]. WQI indicates 17% of the sample were found to be of very poor quality and not consumable. The study's findings offer insights and understanding into groundwater pollution regimes. These results used for water quality assessment leading to improved environmental management and planning and in decision-making for water quality management., (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

This study characterises the quality of groundwater for the Ludhiana district of Punjab, India by analysing water samples collected from 152 locations spread across 3767 km 2 . The samples were analysed for 18 parameters consisting of pH, EC, TDS, TA, TH, major anions and cations. The parameter values have been used to calculate the drinking water quality index of the study area which suggests that 2.6, 57.9, 32.9, 4 and 2.6% of the samples fall under the excellent, good, poor, very poor and unsuitable categories, respectively. The sequence of abundance for ions (in meq/l) as revealed from the laboratory tests is Na + (37.1%) > Ca 2+ (30.8%) > Mg 2+ (29.1%) > K + (2.8%) for cations and HCO 3 - (80%) > Cl ¯ (8.9%) > CO 3 2- (6.5%) > SO 4 2- (3.9%) > NO 3 - , F - , PO 4 3- (< 1%) for anions. The spatial variability of these parameters has been depicted through the use of interpolation maps. Evaluation of different ionic ratios indicates that carbonate weathering and silicate weathering are both significantly affecting the groundwater chemistry with a slight dominance of carbonate weathering. Also, the ion exchange process is taking place in the area as confirmed by CAI index values. In terms of saturation index, the groundwater is undersaturated with respect to halite, fluorite and sylvite, whereas it is supersaturated for calcite, dolomite and aragonite minerals. The principal components in PCA explained 75.4% of the total variance with 29.1 and 28.3% contributions from PC1 and PC2. Both of these components indicate towards the geogenic and anthropogenic influence on groundwater mineralization of the area. The analysis suggests that groundwater for the study area is suitable for drinking in most of the region expect in a few places. Such a study could be used to understand the current status of groundwater quality in the area, the results of which can be used to prevent further contamination and sustain the resource for the future., (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Mercury emissions from the industrial sector have become an undeniable concern for researchers due to their toxic health effects. Efforts have been made to develop green, efficient, and reliable methods for removal of mercury from wastewater. Sorption process promises fruitful results for the decontamination of cations from wastewater. Among the number of used sorbents, metal sulfides have been emerged as an appropriate material for removing toxic metals that possess good affinity due to sulfur-based active sites for Hg through "Lewis's acid-based soft-soft interactions." Herein, nickel-sulfide nanoparticles were synthesized, followed by their incorporation in chitosan microspheres. FTIR analysis confirmed the synthesis of nickel sulfide-chitosan microspheres (NiS-CMs) displaying sharp bands for multiple functional groups. XRD analysis showed that the NiS-CMs possessed a crystallite size of 42.1 nm. SEM analysis indicated the size of NiS-CMs to be 950.71 μm based on SEM micrographs. The sorption of mercury was performed using the NiS-CMs, and the results were satisfactory, with a sorption capacity of 61 mg/g at the optimized conditions of pH 5.0, 80 ppm concentration, in 60 min at 25 °C. Isothermal models and kinetics studies revealed that the process followed pseudo-second-order kinetics and the Langmuir isothermal model best fitted to experimental data. It was concluded that the NiS-CMs have emerged as the best choice for removing toxic mercury ions with a positive impact on the environment., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

The hydrochemical characteristics were analyzed by mathematical statistics, the hydrochemical types were analyzed by Piper three line diagram, and the sources and influencing factors of main ions in surface water were discussed by Gibbs diagram and ion correlation analysis. The results show that the TDS of surface water in the study area is 109-559 mg·L -1 , and the average value is 318.67 mg·L -1 ; The pH value is 6.81-8.62, and the average value is 7.85. Most of them belong to weakly alkaline water. The surface water cation is mainly Ca 2+ and Mg 2+ , the anion is mainly HCO 3 - and the hydrochemical type is HCO 3 -Ca. Through the correlation analysis of the main ions, it can be seen that TDS has a significant positive correlation with Na + , K + , Mg 2+ , Ca 2+ and HCO 3 - , and these ions contribute to TDS. HCO 3 - has a significant correlation with Na + , K + and Mg 2+ and comes from carbonate rocks. According to the analysis of water-rock model, the hydrochemical genesis of surface water in the study area is mainly controlled by rock weathering, most ions are weathered and dissolved by carbonate rock and evaporated salt rock and a few cations are affected by water ion exchange.

In arid and semi-arid regions, groundwater is the principal source of urban and rural water supply. Given that groundwater is the only source of water supply in the Haha region (Moroccan Atlantic coast), the evaluation of this vital resource, using the hydrogeochemical approach, is the main objective of this study. The interpretation of these analytical data showed that the chemical composition of the groundwater is of Ca-Mg-Cl, Na-HCO 3 , and Na-Cl, with the dominance of the first type. Hydrochemical characteristics using the bivariate diagrams of major (Ca 2+ , Mg 2+ , Na + , K + , HCO 3 - , Cl - , NO 3 - , and SO 4 2- ) and some trace elements (Br - and F - ), mineral saturation indices, and statistical analysis show that the water-rock interaction, cation exchange processes, and marine effect are the main processes that control groundwater mineralization. Also, the majority of analyzed samples have concentrations above the thresholds for human consumption fixed by WHO, especially F - , NO 3 - , K + , Cl - , and HCO 3 - concentrations. This requires treatment of this groundwater before any consumption and domestic uses. For agricultural uses, the groundwater of the Haha region remains adequate, especially for plants, which can withstand water with electrical conductivity greater than 1000 µS/cm. However, the results obtained can be used as a basis for decision-makers for better water management in the Haha region., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

89 SrCl 2 radiopharmaceuticals is mainly used for bone pain palliation in the cancer patients, is being produced in FBTR via 89 Y(n, p) 89 Sr using yttria target. The irradiated yttria target is chemically processed in high pure quartz distilled nitric acid medium in hot cell facility, to avoid the corrosion of components of hotcell due to chloride ions while using HCl medium. Being ionic species, the purified 89 Sr(II) cation in aqueous solution containing bulk nitrate and other trace anions, exists as SrX n species where X: F - , Cl - , Br - , NO 3 - , PO 4 3- and SO 4 2- , n: stoichiometric anion content. The aim of the manuscript is to standardise an efficient ultra-low level anion purification method (ppb range) for the conversion of SrX n to SrCl 2 and estimate the residual anionic impurities as recommended by the appropriate source specifications for its medical application. Various methods were standardised for the removal of anions in the SrCl 2 source produced by the above process which include evaporation, calcination, anion exchange column, cation exchange column as well as its combination with pre-concentration column of ion chromatography (IC) technique using 89 Sr tracers as well as FBTR produced 89 Sr solution. Assay of 89 Sr and other anions including nitrate for the above study were accomplished using Cerenkov counting and ion chromatography respectively. Thus evaporation-calcination-column chromatography mode was finalised to obtain pure SrCl 2 source free from nitrate and other anionic impurities. This is the first ever systematic study for the Radiochemical quality control of nca 89 SrCl 2 radiopharmaceutical produced in a fast reactor. This study also finds its application to any analytical lab as well as industry where there is a requirement of anion purification in the ppb level., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

The present study has been carried out to assess the quality of groundwater and surface water resources of Thettiyar watershed, Kerala, India. Sixty-six water samples were collected during pre-monsoon (April, 2019) and monsoon (July, 2019) season, and analyzed for pH, electrical conductivity (EC), total dissolved solids (TDS), total hardness and major cations and anions and microbiological parameters as well. According to the piper diagram's plot, Ca and Mg dominate over Na among the cations, and Cl is the most prevalent anion in groundwater throughout both the studied seasons. The hydrochemical analysis of water samples revealed that all the parameters are within the permissible limit except for pH. For microbiological analysis, the samples were tested for total coliform and fecal coliform. Most of the groundwater samples collected have higher total coliform and fecal coliform (E. coli) content than the recommended count by BIS (2012). The pre-monsoon surface water samples owned a maximum number of 3700 cfu/100 ml (TNTC-too numerous to count) of total coliform and 1400 cfu/100 ml (TNTC) of fecal coliform. In monsoon, the number of total coliform and fecal coliform has increased to 3800 cfu/100 ml and 1900 cfu/100 ml respectively. E. coli and total coliform are effectively correlated with each other in both seasons, in accordance with the statistical study. Domestic, sewage dump, and other household wastes are the main sources of bacterial contamination in the study area, which in turn nourishes contaminant organisms. According to the results, the government or municipality should implement an appropriate system for managing solid waste and should take all necessary measures to clean up the study area., (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Sustainable management of groundwater resources in geological transition zones (GTZ) is essential due to their complex geology, increasing population, industrialization, and climate change. Groundwater quality monitoring and assessment represent a viable panacea to this problem. Therefore, there is a great need to investigate groundwater resources in terms of their chemistry and pollution to ascertain their quality and implement robust pollution abatement strategies. This study focused on the characterization of groundwater in a typical geological transition zone in northeastern Nigeria. Eighty-seven (87) groundwater samples were collected from dug wells and boreholes during the 2017 dry season. pH, conductivity, and total dissolved solids (TDS) were measured in situ using a multiparameter probe, while major cations and anions were measured using atomic absorption spectrometry and ion chromatography, respectively. Data were analyzed using descriptive statistics, principal component analysis (PCA), water quality index, and standard hydrochemical plots. TDS ranged between 95 and 1154 mg L -1 in basement terrains and between 49 and 1105 in sedimentary areas. pH ranged between 6.8 and 7.7 mg L -1 in basement terrains and between 5.0 and 6.5 in sedimentary areas, suggesting a moderately acidic to alkaline low mineralized groundwater. Calcium (2.6-128.0 mg L -1 ) was the dominant cation in the basement areas, suggesting silicate weathering/dissolution, while sodium (1.9-106.0 mg L -1 ) dominated the sedimentary zones due to base exchange reactions. The PCA analysis suggests that mineral dissolution (mostly silicate weathering) controls the hydrochemistry of the basement aquifers, while ion exchange and albite weathering, with some influence of anthropogenic factor, control the sedimentary aquifers. The water quality index revealed that the basement setting was predominated by poor to unsuitable groundwater, while the sedimentary terrain was characterized by potable groundwater. The dominant hydrochemical facie in the basement areas was Ca 2+ -(Mg 2+ )-HCO 3 - characteristic of recharge meteoric water. The Na + - (K + )-HCO 3 - facie characterized the sedimentary zones, indicative of cation exchange reactions, while the mixed water facie typifies the geological contact zones. The shallow nature of the basement groundwaters makes them more susceptible to geogenic and anthropogenic pollution compared to the sandstone aquifers. However, the basement aquifers have better irrigation indices (Kelly ratio and soluble sodium percent) as compared to the sandstone aquifers, which exhibit poor Kelly ratios (< 1) and soluble sodium percent (> 50) ratings. Results from the study clearly highlight the poor-unsuitable groundwater quality in parts of the studied GTZ and can be very instrumental to the policymakers in implementing sustainable water treatment strategies and cleaner production technologies in GTZ to forestall the incidence of water-related diseases., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

The Hohhot Basin, a typical inland basin of the Yellow River Basin in China, has high concentrations of arsenic (As) in its shallow groundwater, while the factors dominating the distribution of high arsenic levels remain to be further identified. An analysis of the ratio of hydrogeochemical compositions can help to reveal the spatial characteristics of the shallow groundwater environmental conditions and the distribution of high-arsenic water (As >10 μg/L). In this study, a total of 170 samples of shallow groundwater in the Hohhot Basin were collected and water samples with As >10 μg/L accounted for 29.4% of the total. Based on the slope changes of the cumulative frequency curves of (HCO 3 - + CO 3 2- )/SO 4 2- , Ca 2+ /(HCO 3 - + CO 3 2- ), Ca 2+ /Mg 2+ , and Na + /Ca 2+ , the groundwater in the study area can be categorized into six different zones according to the environmental characteristics including redox condition, water recharge intensity, and cation exchange level. The result shows that the groundwater in the front of the piedmont alluvial plain and platform is in a weak reducing condition with high lateral recharge intensity, fast runoff, and weak cation exchange. In the Dahei River alluvial plain, which serves as the groundwater discharge zone, the groundwater runoff is sluggish with poor lateral recharge, sufficient exchange between cations in the groundwater and the aquifer matrix, and enhanced reducibility. The degree of oxidation increased in the groundwater near the Hasuhai Lake and the drainage canal, which adverse to the arsenic enrichment. High-arsenic groundwater is mainly distributed in aquifers of (HCO 3 - + CO 3 2- )/SO 4 2 > 10, Na + /Ca 2+ > 13, and Ca 2+ /(HCO 3 - + CO 3 2- ) < 0.1, which represent the strong reducing condition, low surface water recharge intensity, and strong cation exchange condition. Reductive dissolution of iron oxide, strong evaporation and concentration process, and competition from phosphate in aquifers jointly lead to the release of arsenic into groundwater., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

In this study, we assessed the capacity of a previously reported engineered liposomal formulation, which had been tested against model membranes mimicking the lipid composition of the HeLa plasma membrane, to fuse and function as a nanocarrier in cells. We used atomic force microscopy to observe physicochemical changes on the cell surface and confocal microscopy to determine how the liposomes interact with cell membranes and released their load. In addition, we performed viability assays using methotrexate as an active drug to obtain proof of concept of the formulation´s capacity to function as a drug delivery-system. The interaction of engineered liposomes with living cells corroborates the information obtained using model membranes and supports the capacity of the engineered liposomal formulation to serve as a potential nanocarrier., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)

Capillary electrophoresis (CE) systems have undergone extensive development for spaceflight applications. A flight-compatible high voltage power supply and the necessary voltage isolation for other energized components can be large contributors to both the volume and mass of a CE system, especially if typical high voltage levels of 25-30 kV are used. Here, we took advantage of our custom CE hardware to perform a trade study for simultaneous optimization of capillary length, high voltage level, and separation time, without sacrificing method performance. A capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C 4 D) method recently developed by our group to target inorganic cations and amino acids relevant to astrobiology was used as a test case. The results indicate that a 50 cm long capillary with 15 kV applied voltage (half of that used in the original method) can be used to achieve measurement goals while minimizing instrument size., (© 2022 Wiley-VCH GmbH. California Institute of Technology. Government sponsorship acknowledged.)

Human lactoferrin (hLF) is one of the most important whey proteins in human milk, known for its ability to modulate innate host immunity and multifunctional activities for neonatal growth. The objective of this study was to validate an efficient method for the detection and quantification of hLF using a unique technology of cation-exchange high-performance liquid chromatography (HPLC) on CIM® monolithic columns. Human milk samples were collected using manual expression or a breast pump, at different weeks of lactation. After sample preparation, hLF was detected and measured by HPLC method and further confirmed by SDS-PAGE. Selected fractions were analysed also by LC-MS/MS. Presumably, due to the high density of positive charge on the surface of the N-terminal domain, hLF binds strongly to the column and elutes last, enabling the high specificity of this method. The LC-MS/MS analysis indicated that hLF eluted in two clearly separated peaks, presumably representing two different molecular species of hLF. hLF concentration in the human milk samples ranged from 2.03 mg/mL to 5.79 mg/mL and was not significantly affected by the sample collection method whereas it was negatively correlated with the stage of lactation. These results suggest that cation exchange chromatography is an accurate, efficient, and robust method for the detection and quantification of hLF., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Cesium (Cs + ) enters environments largely because of global release into the environment from weapons testing and accidents such as Fukushima Daiichi and Chernobyl nuclear waste. Even at low concentrations, Cs + is highly toxic to ecological receptors because of its physicochemical similarity to macronutrient potassium (K + ). We investigated the uptake and accumulation of Cs + by Arthrobacter globiformis strain 151B in reference to three similar alkali metal cations rubidium (Rb + ), sodium (Na + ), and potassium (K + ). The impact of hexavalent chromium (Cr +6 ) as a co-contaminant was also evaluated. A. globiformis 151B accumulated Cs + and Cr 6+ in a time-dependent fashion. In contrast, the uptake and accumulation of Rb + did not exhibit any trends. An exposure to Cs + , Rb + , and Cr +6 triggered a drastic increase in K + and Na + uptake by the bacterial cells. That was followed by the efflux of K + and Na + , suggesting a Cs + "substitution." Two-dimensional gel-electrophoresis of bacterial cell proteomes with the following mass-spectrometry of differentially expressed bands revealed that incubation of bacterial cells with Cs + induced changes in the expression of proteins involved in the maintenance of cellular homeostasis and reactive oxygen species removal. The ability of A. globiformis 151B to mediate the uptake and accumulation of cesium and hexavalent chromium suggests that it possesses wide-range bioremediation potential., (© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

The aim of the study was to determine the groundwater characteristics of rural and industrial zones in the Kannur region. In 2011, 25 groundwater data were collected from the centre for water resource development management (CWRDM), and in 2019, 25 groundwater samples from rural and near-industrial areas were collected and analysed for major anions (HCO 3 -, CO 3 2- , Cl - , NO 3 - and SO 4 2- ), and cations (TH, Ca 2+ , Mg 2+ , Na + , K + and Fe 2+ ) using APHA standards. To better understand the link between water quality parameters, multivariate statistical analysis approaches such as principal component analysis (PCA), hierarchical cluster analysis (HCA), correlation matrix analysis (CMA), and Pearson correlation bivariate one-tailed analysis (PCBOTA) were used to analyse the inter-relationship of data. The Inverse Distance Weighed (IDW) method was used to generate the spatial distribution of the groundwater quality index (GWQI). In 2011, the water quality index (WQI) value of groundwater samples was excellent at 24.42% and good at 54.14%, which were used for drinking purposes and moderate at 17.22% and poor at 4.22% for irrigation purposes in this study area. In 2019, excellent 21.62%, good 51.56% were used for drinking purpose, and moderate at 18.14%, and poor at 8.68% for irrigation purposes. By comparing the data with BIS and WHO standards, it is clear that groundwater in Kannur district is of good quality. In groundwater samples, the PCA eigen values were reported in 2011 (84.7%) and 2019 (73.4%) for statistical approaches. This study uses HCA and PCBOTA to analyse the elements, resulting in a better understanding of groundwater quality development. GIS based WQI maps were obtained and utilised to gain a better knowledge of the study area's past and present water quality status. We observed that the quality of groundwater in the study region's north-western portion is insufficient for drinking water., (© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Ismailia Canal is one of the significant streams of the Nile River in Egypt. The study aimed to determine the water quality of Ismailia Canal based on the regional and seasonal variability of physicochemical parameters, irrigation criteria, and the irrigation water quality index (IWQI). It was observed that the physicochemical parameters were within the acceptable FAO irrigation limits. All cations and anions values were within the acceptable FAO limits for irrigation, except the potassium (K + ) concentrations were over the permissible irrigation limits. The one-way analysis of variance (ANOVA) suggested a significant seasonal variation in the canal's water quality concerning all parameters (p value ˂ 0.05). However, the regional variation among various sites was statistically insignificant (p value > 0.05). Statistical analysis was used to calculate the correlation coefficient between different parameters, and the study showed highly significant correlation coefficients between different pairs of water quality parameters. The correlation matrix showed that the pH significantly affected IWQI (r = 0.661). The irrigation criterion values for Ismailia Canal were good, and the WQI levels for irrigation utilization at all studied sites were satisfactory. Deterioration of water quality may occur due to industrial, municipal, and agricultural activities. Drainage water should be treated before being mixed with irrigation water to improve its suitability for irrigation., (© 2022. The Author(s).)

Claudins (Cldns) form a large family of protein homologs that are essential for the assembly of paracellular tight junctions (TJs), where they form channels or barriers with tissue-specific selectivity for permeants. In contrast to several family members whose physiological role has been identified, the function of claudin 4 (Cldn4) remains elusive, despite experimental evidence suggesting that it can form anion-selective TJ channels in the renal epithelium. Computational approaches have recently been employed to elucidate the molecular basis of Cldns' function, and hence could help in clarifying the role of Cldn4. In this work, we use structural modeling and all-atom molecular dynamics simulations to transfer two previously introduced structural models of Cldn-based paracellular complexes to Cldn4 to reproduce a paracellular anion channel. Free energy calculations for ionic transport through the pores allow us to establish the thermodynamic properties driving the ion-selectivity of the structures. While one model shows a cavity permeable to chloride and repulsive to cations, the other forms barrier to the passage of all the major physiological ions. Furthermore, our results confirm the charge selectivity role of the residue Lys65 in the first extracellular loop of the protein, rationalizing Cldn4 control of paracellular permeability., (© 2022 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences.)

In the current survey, different hydrogeochemical processes governing the geochemistry of aquifers, the usefulness of groundwater for regular consumption, and agricultural purposes were evaluated around the Tummalapalle area. One hundred forty-four borehole locations were chosen to characterize the major physicochemical components of the aquifer water. The analysis results of pH inferred that the groundwater is nominally acidic to basic, and pH ranged from 6.6 to 8.4. The average concentrations of TDS, Ca 2+ , Mg 2+ , total hardness (TH), HCO 3 - , and total alkalinity (TA) are within the allowable limits of potable water quality as prescribed by the Bureau of Indian Standards (BIS) and WHO. However, the average concentrations of Na + , K + , Cl - , and SO 4 2- were all below the permissible limit. All samples were analyzed with the help of Piper and Chadha charts to determine the dominant hydrogeochemical components of groundwater. The dominance of cations in groundwater in this region is in the sequence of Ca 2+  > Na +  > Mg 2+  > K + , followed by anions HCO 3 -  > Cl -  > SO 4 2- . The Gibbs plot analysis suggested the predominance of rock aquifer interaction as the major hydrogeochemical process governing groundwater geochemistry in this region. The water quality index (WQI) of all groundwater samples in the Tummalapalle region was estimated, with 55% of the samples being potable grade. The different irrigation indices were analyzed for the groundwater samples to estimate their desirability for agriculture. The maximum number of water samples was found to be well-suited for cultivation., (© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Increasing interest in the detection of biogenic signatures, such as amino acids, on icy moons and bodies within our solar system has led to the development of compact in situ instruments. Given the expected dilute biosignatures and high salinities of these extreme environments, purification of icy samples before analysis enables increased detection sensitivity. Herein, we outline a novel compact cation exchange method to desalinate proteinogenic amino acids in solution, independent of the type and concentration of salts in the sample. Using a modular microfluidic device, initial experiments explored operational limits of binding capacity with phenylalanine and three model cations, Na + , Mg 2+ , and Ca 2+ . Phenylalanine recovery (94-17%) with reduced conductivity (30-200 times) was seen at high salt-to-amino-acid ratios between 25:1 and 500:1. Later experiments tested competition between mixtures of 17 amino acids and other chemistries present in a terrestrial ocean sample. Recoveries ranged from 11% to 85% depending on side chain chemistry and cation competition, with concentration shown for select high affinity amino acids. This work outlines a nondestructive amino acid purification device capable of coupling to multiple downstream analytical techniques for improved characterization of icy samples at remote ocean worlds.

A new, simple and sensitive ion chromatography (IC) method for the determination of sodium, potassium, magnesium, calcium and chloride in a parenteral nutrition (PN) solution was developed and validated. Before sample analysis, a sample pretreatment by calcination was applied which could totally remove interference from other constituents of the PN solution. Methanesulfonic acid (MSA) and sodium hydroxide were used as the mobile phase for the determination of cations and anions, respectively. The calibration curves showed good correlation between analyte peak area and concentration (r2 > 0.999). Detection limits ranged from 0.0001 to 0.02 mg/L and quantification limits from 0.0002 to 0.06 mg/L. Relative standard deviation (RSD) values for repeatability and inter-day precision did not exceed 1.0% and the recoveries for all analytes were between 99.1−101.1%. The robustness was verified by using an experimental design.

The present research has been performed to analyze the chemical behavior of rainwater of the Shaune Garang catchment (32.19° N, 78.20° E) in the Baspa basin, located at a high elevation (4221 m above mean sea level) in the Himachal Himalaya, India. During the study period, sixteen rainwater samples were collected from the Shaune Garang catchment at five different sites. The volume-weighted mean (VWM) pH value of rainwater ranged between 4.59 and 6.73, with an average value of 5.47 ± 0.69, indicating the alkaline nature of rainfall. The total ionic strength in the rainwater ranged from 113.4 to 263.3 µeq/l with an average value of 169.1 ± 40.4 µeq/l. The major dominant cations were Ca 2+ (43.10%) and Na + (31.97%) and anions were Cl - (37.68%), SO 4 2- (28.71%) and NO 3 - (23.85%) in rainwater. The ionic ratios were calculated among all the ions. The fraction of (NO 3 -  +Cl - ) with SO 4 2- was measured as 2.3, which specifies sour faces of rainwater due to HNO 3 , H 2 SO 4 , and HCl. A multivariate statistical assessment of rainwater chemistry through Principal Component Analysis (PCA) shows the significance of four factors controlling 78.37% of the total variance, including four-component (PC1 explained 27.89%, PC2 explained 24.98%, PC3 explained 14.64%, PC4 explained 10.85%). However, the individual contribution of Factor 1(PC1) explains 27.89% of the total variance (78.37%) and displays a strong optimistic loading for Ca 2+ and Cl - . Further, high loading of Ca 2+ and NO 3 - and moderate loading of SO 4 2- signify the contribution of burning fossil fuel and soil dust. Anthropogenic and natural pollutants influence the composition of rainwater in the pristine Himalayas due to local and long-distance transportation. The study area receives precipitation from the West and North-West, transporting dust and fossil fuel emissions from the Thar Desert and Northwestern countries., (© 2022. The Author(s).)

In order to deal with the environmental resource problems caused by nuclear pollution and uranium mine wastewater, it is particularly important to develop uranium removal adsorbent materials with low cost, high efficiency and controllable rapid preparation. In this work, the hollow grape-like manganese phosphate clusters (h-MnPO 4 ) were synthesized in 4 h by in-situ etching without template at room temperature, which can quickly and effectively remove uranium ions from wastewater. Due to the reasonable hollow structure, more effective adsorption sites are exposed. The obtained sample h-MnPO 4 -200 reaches adsorption equilibrium in 1 h and can remove 97.20% uranyl ions (initial concentration is 100 mg L -1 ). Under the condition of 25 ℃ and pH= 4, the maximum adsorption capacity of h-MnPO 4 -200 for uranium was 751.88 mg g -1 . The FT-IR, XPS and XRD analysis showed that -OH and PO 4 3- groups played a key role in the adsorption process. Thanks to the synergistic adsorption mechanism of surface complexation and dissolution-precipitation, h-MnPO 4 -200 maintained a high removal rate in the presence of competitive anions and cations. In a word, h-MnPO 4 -200 can be rapidly synthesized through a facile and low-cost method and has a great application prospect in the practical emergency treatment of uranium-containing wastewater., (Copyright © 2022 Elsevier B.V. All rights reserved.)

This work aims to develop a more robust, easy-to-use, low-pressure, and cost-effective nonsuppressed open tubular capillary ion chromatography (NS-OTIC) approach with online dialysis for small ions determination in drinks. The fabricated device was applied for two selected columns, including poly(butadiene-maleic acid) on a 50-μm bore and AS18 Latex on 25-µm bore fused silica capillaries, for the separation of mixed cations (Na + , K + , Ca 2+ , Mg 2+ ) and mixed anions (Cl - , Br - , NO 2 - , NO 3 - ), respectively. High concentrations of ions (up to 100 mM) level can be directly introduced into the NS-OTIC system without an off-line (manual) dilution step. The linear relationship of the peak area and concentration of model ions can be obtained with a resolution > 1.1. The repeatability of the peak area for both OTIC columns was < 6% RSD. Juice and tea samples were successfully analyzed with % recoveries of 77-112 and 90-119 for cation and anion determinations, respectively., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

In this study,the water samples were collected from 31 sites of Tawang, Arunachal Pradesh, India (North-Eastern Himalaya), during the winter season to check the suitability of water for drinking and irrigation purposes.The study scientifically demonstrates the estimation of Water quality index (WQI) andhydrogeochemical characteristics of surface water samples by utilizing multivariate statistical methods. The main water quality parameters considered for this study were TDS, conductivity, salinity, pH, hardness, cations and anions. WQI was calculated in order to find out the deviation in the water quality parameters particularly with respect to BIS permissible limits.The major influencing factors responsible for the variation in these parameters were derived by using Principal component analysis (PCA) and Correlation matrix.To check the suitability of water for drinking purpose, hydrogeochemical facies and rock water interaction was derived by using well established methods such as Piper Plot (determine water type), WQI (Quality monitoring), and saturation index (for mineral dissolution). The results revealed that the silicate weathering was the main ionic source in comparison to carbonate weathering which is due to the higher dissolution capacity of silicate minerals.The results of the scattered plot between (Ca 2+  + Mg 2+ )-(HCO 3 - + SO 4 2 -) versus (Na +  + K + )-Cl- (meq/L) highlighted thation exchange occurs between Mg 2+ and Ca 2+ ofsurface water with Na + and K + of rock /soil. This means that calcium ion was getting adsorbed, and sodium ion was getting released. The Ca 2+ -Mg 2+ -HCO 3 -, Na + -HCO 3 -and Na + -Cl- type of surface water suggested permanent and temporary hardness respectively in the studied region. The dominant cations of this study were Na + and Ca 2+ while the dominant anions were HCO 3 - and SO 4 2 -. In order to check the suitability of water sources for irrigation, parameters like, Magnesium hazard (MH), Total hardness (TH), Permeability Index (PI), Kelly Index (KI), Sodium adsorption rate (SAR), Sodium percentage (Na%), and Residual sodium carbonate (RSC) were determined. The results showed that 93% of the samples had PI score < 75, which indicates the suitability of the water for irrigation. Also the WQI calculation showed an average WQI value of 82.49, amongst which 61% samples were in the range of 0-50 being considered as good for drinking, while 39% were catageorised as unsuitable for drinking showing a value of > 50. Hence the above findings reveal that geogenic activities play a major role in influencing the water quality of Tawang region. Hence suitable water treatment technologies or methods might be used to eliminate thenon desirable elements and minerals present in surface water., (© 2022. The Author(s).)

In spite of the fact that rock weathering performs an essential task in the evolution of the Earth's surface, the quantitative assessment between pH and rates of chemical weathering remain unclear. This study aims to characterize the chemical weathering rate of purple rocks and then develops a model to calculate the release rates of cations (K + , Na + , Ca 2+ and Mg 2+ ) under various pH conditions. Two types of purple rock were sampled from the Shaximiao Group (J 2 s) and Penglaizhen Group (J 3 p), and a series of laboratory experiments were performed by soaking the purple rocks in solutions with pHs from 2.5 to 7.0, over 24 treatment cycles. The results showed that the release rates of cations apparently increased as the pH decreased. The release of Ca 2+ was the dominant process of chemical weathering in J 3 p under various pH treatments, while K + and Na + were remarkably high in J 2 s (with the exception of the pH 2.5 treatment). Quantitative analysis revealed that the rate of cation release was significantly related to the H + concentration (p < 0.001) and the air temperature (p < 0.001). The relationship between cation release and acidity was found to be an exponential function. Our results suggested that solution acidity serves as an important driving force for cation release rates from purple rocks and that environmental acidification would enhance rock weathering., (© 2022. The Author(s).)

This technical note illustrates the possibility of using a conductivity cell electrode (CCE) as an ion chromatography (IC) detector to extend the application fields of this analytical technique. A conventional non-suppressed IC system consists of an eluent delivery pump, a separation column, column oven, and conductivity detector (CD). In this study, the conventional CD, which is one of the expensive parts of the instrument, is replaced with a relatively inexpensive CCE, leading to comparable peak resolution, detection sensitivity, and relative standard deviation. The separation effectiveness was retained and the developed IC-CCE system was successfully applied to the simultaneous separation of inorganic anions (SO 4 2- , Cl - , and NO 3 - ) and cations (Na + , NH 4 + , K + , Mg 2+ , and Ca 2+ ) in three natural mineral water samples, with good accordance between the monitored values obtained using the CCE and CD. The commercially available CCE is potentially suitable for application as an IC detector for monitoring ionic components with overall IC cost reduction.

This study focused on the extraction, purification, and physicochemical characterization of γ-conglutin, a protein present in lupin seeds with properties of reducing blood glucose levels. Total protein was extracted with an alkaline-saline solvent, followed by isoelectric precipitation. Chromatographic purification of the precipitated fraction was performed using a cation exchange supermacroporous cryogel column. Electrophoresis of the eluted fraction from chromatography presented a single band of ∼48 kDa under non-reducing conditions (two bands of ∼30 and ∼17 kDa, under reducing conditions) confirming the success of the purification protocol. Liquid chromatography-tandem mass spectrometry analysis confirmed the identity of the protein as γ-conglutin. The purified γ-conglutin had an isoelectric point of 7.51, β-sheets prevailing as a secondary structure, and denaturation temperature close to 68°C. The outcome of this work showed that γ-conglutin was obtained with a high degree of purity. The proposed purification protocol is simple and can be easily scaled up., (© 2021 Wiley-VCH GmbH.)

Background: Red lettuce is consumed worldwide because it is a great source of natural antioxidants. To design a fertilizer formula to boost its nutritional value, this research simultaneously studied the effects of significant cations among the macronutrients for plant growth (K, Mg and Ca) and the effects of the electrical conductivity (EC) of the nutrient solution on phenolic compound production and mass productivity of hydroponically grown red lettuce., Results: Red lettuce grown under the control treatment provided the highest mass productivity (under low-stress conditions). The highest antioxidant content, measured as milligrams of phenolic compounds per gram dry weight (at a high-stress condition) via both Folin-Ciocalteu and HPLC analyses, was observed in growth media containing 100 ppmK : 20 ppm Mg : 70 ppm Ca (with EC equal to 1241 μS cm -1 ). It was found that EC within the range of this examination had no significant effect on the mass productivity or on phenolic compound productivity. The phenolic compound productivity, defined as the amount of phenolic compounds produced per unit of planting area per unit of time, was optimized with the optimum formula for maximum phenolic compound productivity of 90 ppm K : 29 ppm Mg : 77 ppm Ca, or a corresponding EC of 1307 μS cm -1 ., Conclusions: The study demonstrates that health-promoting nutrient production in red lettuce could be stimulated in a practical manner by adjusting the cation concentrations in fertilizer solution. © 2021 Society of Chemical Industry., (© 2021 Society of Chemical Industry.)

Rationale: Radical cationization of endogenous hydrocarbons in cherry tomatoes was previously reported using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI), a mass spectrometry imaging technique that operates at ambient conditions and requires no sample derivatization. Due to the surprising nature of this odd-electron ionization, subsequent experiments were performed on β-carotene to determine the amount of radical cationization across different sampling conditions., Methods: β-Carotene was analyzed across a variety of sample states using IR-MALDESI followed by Orbitrap mass spectrometric analysis: first, as a standard in ethanol in a well plate; second, as particulates on printer paper; and third, as particulates covered by an ice matrix. These techniques were also performed with a β-carotene standard either in solution with a reducing agent (ascorbic acid) or with ascorbic acid in the electrospray solution., Results: Tandem mass spectrometry confirmed the presence of the radical cation of β-carotene by comparing fragments against NIST and METLIN databases. It was always analyzed as a radical cation when sampled from solution, where ascorbic acid increased radical cation abundance when in solution with β-carotene. Mixed-mode ionization between radical cationization and proton adduction was observed from dried particulates using IR-MALDESI., Conclusions: There are several potential mechanisms for β-carotene radical cationization prior to IR-MALDESI analysis, with multiphoton ionization, thermal degradation, and/or reaction with oxygen appearing to be the most logical explanations. Furthermore, although not the primary cause, changing certain aspects of sample conditions can result in significant mixed-mode ionization with competing protonation., (© 2021 John Wiley & Sons Ltd.)

Cationic contrast-enhanced computed tomography (CECT) is a quantitative imaging technique that characterizes articular cartilage, though its efficacy in differentiating repair tissue from other disease states is undetermined. We hypothesized that cationic CECT attenuation will distinguish between reparative, degenerative, and healthy equine articular cartilage and will reflect biochemical, mechanical, and histologic properties. Chondral defects were created in vivo on equine femoropatellar joint surfaces. Within defects, calcified cartilage was retained (Repair 1) or removed (Repair 2). At sacrifice, plugs were collected from within defects, and at locations bordering (adjacent site) and remote to defects along with site-matched controls. Articular cartilage was analyzed via CECT using CA4+ to assess glycosaminoglycan (GAG) content, compressive modulus (E eq ), and International Cartilage Repair Society (ICRS) II histologic score. Comparisons of variables were made between sites using mixed model analysis and between variables with correlations. Cationic CECT attenuation was significantly lower in Repair 1 (1478 ± 333 Hounsfield units [HUs]), Repair 2 (1229 ± 191 HUs), and adjacent (2139 ± 336 HUs) sites when compared with site-matched controls (2587 ± 298, 2505 ± 184, and 2563 ± 538 HUs, respectively; all p < .0001). Cationic CECT attenuation was significantly higher at remote sites (2928 ± 420 HUs) compared with Repair 1, Repair 2, and adjacent sites (all p < .0001). Cationic CECT attenuation correlated with ICRS II score (r = .79), GAG (r = .76), and E eq (r = .71; all p < .0001). Cationic CECT distinguishes between reparative, degenerative, and healthy articular cartilage and highly correlates with biochemical, mechanical, and histological tissue properties., (© 2020 Orthopaedic Research Society. Published by Wiley Periodicals LLC.)

Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with mass spectrometry technology provides a unique method for distinguishing the enantiomeric drugs, enantiomeric identification, and quantitation in the gas phase. In this study, enantiomeric molecules of ibuprofen and flurbiprofen were clearly recognized by forming host-guest complex ions using trapped ion mobility time-of-flight mass spectrometry. Ternary complex ions can be produced easily by electrospray ionization of the mixed solutions of ibuprofen, cyclodextrins, and CaCl 2 , LiCl, or NaCl, as well as flurbiprofen, cyclodextrins, and CaCl 2 . The relative contents of different chiral ibuprofens in a mixed solution were also quantitatively measured. This new method is a simple, effective, and a convenient enantioselective analysis method., (© 2021 Wiley-VCH GmbH.)

In this study, a background electrolyte capable to separate and quantify inorganic cations in high ionic strength samples by UV-absorption indirect detection was designed. In this regard, the four most abundant monovalent and divalent cations in earth crust (K + , Na + , Ca +2 , Mg +2 ) were selected as model compounds. A group of small carboxylic acids and, several toluidines and pyridines were evaluated as mild strength complexing agents and chromophoric probes, respectively. The optimized background electrolyte was composed of 200 mM 2,4,6-trimethylpyridine as the chromophoric probe, 250 mM lactic acid as the weak complexing agent and pH buffering reagent (adjusted to pH 4.5), and 5% v/v methanol as organic solvent modifier. Based on a minimum number of components, it provided outstanding separation performance in less than 4 min in a wide linear dynamic range (10 - 2500 µg·mL -1 ). Performances were contrasted against a reference method based on conductometric detection. Furthermore, studies of separation efficiency and peak shape were carried out at different analyte concentrations in high electric conductivity solutions. The herein developed method demonstrated exceptional features in terms of limits of detection (~10 µg·mL -1 ), resolution, speed of analysis, sensitivity and peak capacity in high electric conductivity samples. Moreover, the method was successfully applied to high ionic strength samples such as rock digest, sea water, soy sauce and isotonic drinks., Competing Interests: Declaration of Competing Interest None., (Copyright © 2021. Published by Elsevier B.V.)

We evaluate stability of cesium (Cs) and other alkali-metal cation complexes of lichen metabolites in both gas and aqueous phases to discuss why lichens can retain radioactive Cs in the thalli over several years. We focus on oxalic acid, (+)-usnic acid, atranorin, lecanoric acid, and protocetraric acid, which are common metabolite substances in various lichens including, e.g., Flavoparmelia caperata and Parmotrema tinctorum retaining Cs in Fukushima, Japan. By performing quantum chemical calculations, their gas-phase complexation energies and aqueous-solution complexation free energies with alkali-metal cations are computed for their neutral and deprotonated cases. Consequently, all the molecules are found to energetically favor cation complexations and the preference order is Li[Formula: see text]Na[Formula: see text]K[Formula: see text]Rb[Formula: see text]Cs[Formula: see text] for all conditions, indicating no specific Cs selectivity but strong binding with all alkali cations. Comparing complexation stabilities among these metabolites, lecanoric and protocetraric acids seen in medullary layer are found to keep higher affinity in their neutral case, while (+)-usnic acid and atranorin in upper cortex exhibit rather strong affinity only in deprotonated cases through forming stable six atoms' ring containing alkali cation chelated by two oxygens. These results suggest that the medullary layer can catch all alkali cations in a wide pH range around the physiological one, while the upper cortex can effectively block penetration of metal ions when the metal stress grows. Such insights highlight a physiological role of metabolites like blocking of metal-cation migrations into intracellular tissues, and explain long-term retention of alkali cations including Cs in lichens containing enough such metabolites to bind them.

Novel polyepinephrine-modified NaYF 4 :Yb,Tm upconversion luminescent nanoparticles (UCNP@PEP) were prepared via the self-polymerization of epinephrine on the surfaces of the UCNPs for selective sensing of Fe 3+ inside a cell and for intracellular imaging. The proposed UCNP@PEP probe is a strong blue light emitter (λ max  = 474 nm) upon exposure to an excitation wavelength of 980 nm. The probe was used for detecting Fe 3+ owing to the complexation reaction between UCNP@PEP and Fe 3+ , resulting in reduced upconversion luminescence (UCL) intensity. The proposed probe has a detection limit of 0.2 μM and a good linear range of 1-10 μM for sensing Fe 3+ ions. Moreover, the UCNP@PEP probe displays high cell viability (90%) and is feasible for intracellular imaging. The ability of the probe to sense Fe 3+ in a human serum sample was tested and shows promising output for diagnostic purposes. The prepared UCNP@PEP probe was characterized by using UV-visible (UV-Vis) absorption spectrometry, fluorescence (FL) spectrometry, field emission scanning electron microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FT-IR).

An on-site ion analyzer based on capillary electrophoresis with pressure-driven flow through injection and capacitively coupled contactless conductivity detection has been developed for field monitoring of cations and anions in environmental waters. Automated time-pressure based hydrodynamic injection provides stable pL-nL scale injection (RSD = 1.96%, n = 30). A mixture of 400 mM Bis-Tris, 400 mM MOPS and 2 mM 18-crown-6 is used as the background electrolyte to provide repeatable separations. A proprietary hydrophilic coated 25 μm id capillary is used to suppress the electroosmotic flow. Separations of anions (Cl - , NO 3 - , NO 2 - , SO 4 2- , F - and PO 4 3- ) and cations (NH 4 + , K + , Na + , Ca 2+ and Mg 2+ ) are achieved by switching the polarity of the high voltage power supply in two individual runs. Signal fluctuations caused by the temperature or viscosity changes in on-site monitoring are corrected by on-line introduction of internal standards. RSDs of the migration time and the corrected peak height over ~35 h and 350 analysis cycles are <4.06%. The LODs of inorganic ions are in the range of 2.1 μM (K + ) to 6.8 μM (PO 4 3- ).  The feasibility for on-site water monitoring with this system has been validated by a standard Ion chromatography method with comparable results obtained., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020. Published by Elsevier B.V.)

A sumanene derivative functionalized with triphenylbenzene units was found to exhibit aggregation-induced emission enhancement (AIEE). A disaggregation process after the addition of caesium cations (Cs+) was observed. This feature was employed for the design of the first sumanene-containing disaggregation-based fluorescent probe for specific, efficient and fast Cs+ recognition.

The chemical quality of groundwater supplies in two high-risk area (HRA) and low-risk area (LRA) for gastric cancer in Iran was assessed through hydrogeochemical analysis and water quality indices. For this aim, Piper and Schoeller diagrams and water quality index (WQI) were applied. In addition, exposure to nitrate via drinking water and its corresponding risk were also assessed using Monte Carlo simulation technique. Data on physicochemical properties of groundwater resources were obtained from Iran Water Resources Management Company. Sampling and analysis of tap water for nitrate concentration were conducted in two cities of Shiraz (as a representative of LRA) and Ardabil (as a representative of HRA). According to Piper diagrams, the dominant hydrogeochemical facies of groundwater supplies in HRA and LRA were Na-HCO 3 (43.75%) and Ca-HCO 3 (41.77%), respectively. The predominant cations in groundwater resources of HRA were found to be Na + (68.06%) and Ca 2+ (31.94%). For LRA, the typical cations were in decreasing trend: Ca 2+ (39.64%) > Mg 2+ (18.35%) > Na + (17.26%). For two areas, HCO 3 - , SO 4 2- and Cl - were, respectively, the most frequent anions. Two-sample Wilcoxon test showed that there were statistically significant difference between two areas in terms of anions and cations concentrations (p value < 0.05). The mean of total hardness (Ca 2+  + Mg 2+ ) concentration of water supplies in LRA (528.1 mg/L) was higher than HRA (263.1 mg/L), whereas the mean of Na + concentration was found to be lower in LRA (90.6 mg/L) compared with HRA (108.1 mg/L). The sum of nitrate intake and its risk in LRA was higher than HRA. WQI results showed that drinking water quality in HRA and LRA ranged from excellent to poor and most water resources were of a good quality class. Further studies are suggested to investigate the role of drinking water in the etiology of gastric cancer in Iran.