Search

Background: Reticulocytes are red blood cell precursors with an average lifespan of 1-2 days. Reticulocyte hemoglobin equivalent (Ret-He) is an early marker of iron deficiency (ID) erythropoiesis and reflects real-time information regarding the synthesis of young erythrocytes in the bone marrow. The objective of this study is to determine the diagnostic utility of Ret-He in patients having microcytic hypochromic anemia in comparison with serum ferritin and iron studies. Objectives: The objective of this study is to determine the diagnostic utility of the Ret-He parameter in patients having microcytic hypochromic anemia in comparison with the serum ferritin, iron studies and its role in routine hematological screening for nutritional deficiency anemia like ID. Design and Settings: The design involves observational study. Materials and Methods: A hospital-based observational study was carried out in a referral hospital. Hematological parameters were processed using Sysmex XN1000 (Sysmex Corporation, Kobe, Japan) analyzer and were compared with Serum iron studies using biochemistry analyzer (VITROS® 250 Chemistry System) from 201 participants who presented with microcytic hypochromic anemia. Main Outcome and Measures: Relationship of Ret-He parameter and its diagnostic utility for screening of iron-deficient states. Sample Size: The sample size was 201. Results: When serum ferritin is taken as "the gold standard" to detect ID, with Ret-He cutoff of 27.15 pg/cell, we found a statistically significant positive correlation between Ret-He and serum ferritin (P < 0.001). We found a sensitivity of 57.37% and specificity of 75.95% with area under the curve of 0.681, positive predictive value of 100%, negative predictive value of 3.8%, and accuracy of 62.19% for Ret-He in detecting ID anemia (IDA). Also found a statistically significant negative correlation between Ret-He and total iron binding capacity (P < 0.001). There was no statistical correlation between Ret-He and serum iron levels in our study. Conclusions: The present study suggests Ret-He is one of the better and more reliable hematological parameters indicating ID and, when used along with biochemical parameters like serum ferritin, can give valuable inputs in a better screening and diagnosis of IDA; hence proper treatment is possible. Limitations: The multicentric study is required to standardize Ret-He reference values, and follow-up to therapy of the subjects was not done. Additional hemoglobin variant analysis data would have been favorable to the study. [ABSTRACT FROM AUTHOR]

Sports medicine, as a classical cross-sectional subject, includes diverse topics which show gender-specific differences and thus require a differentiated consideration. Evidence-based research exists in the field of musculoskeletal medicine, for example, in relation to cruciate ligament injuries or concussions. Marked differences in trainability (both muscular and cardiac or pulmonary) are also emerging. Pregnancy and sport is also a topic of increasing interest. Close interdisciplinary care of female athletes, knowledge of physiological changes during pregnancy and contraindications to sports activity (especially with higher intensity) are essential here. Aspects in the field of internal sports medicine with gender differences are topics like iron deficiency or the relative energy deficit (REDS). There are also sex and gender differences with implications for preventative aspects such as the annual screening examination (so called 'preparticipation screening'). [ABSTRACT FROM AUTHOR]

Au cours de l'insuffisance rénale chronique, l'anémie et la malnutrition couplées à l'inflammation sont fréquentes et considérées comme des facteurs de morbi-mortalité. Le lien entre ces deux facteurs a longuement été décrit dans la littérature, mettant en avant une association de la malnutrition avec la carence en fer, considérée elle-même comme l'une des causes de l'anémie chez les patients en insuffisance rénale chronique (non dialysés et hémodialysés). Notre étude a pour objectif de connaître la prévalence de ces deux facteurs dans une population d'insuffisance rénale chronique (non dialysés et hémodialysés) d'Alger, et de mettre en évidence les possibles associations entre eux. Il s'agit d'une étude multicentrique, transversale et descriptive, réalisée sur une période de 6 mois (août 2018 à janvier 2019). L'anémie et la malnutrition ont été évaluées par divers outils biologiques et clinico-biologiques tels que le score de malnutrition et d'inflammation et les critères de l' International Society of Renal Nutrition and Metabolism. Les tests statistiques ont été réalisés avec le logiciel R studio® en considérant p < 0,05 comme valeur statistiquement significative. Nous avons inclus 209 patients en insuffisance rénale chronique (90 non dialysés et 119 hémodialysés). La médiane d'âge était de 70 ans (IQR = 16) pour les non-dialysés et de 56 ans (IQR = 16,5) pour les hémodialysés. La prévalence de l'anémie était de 66,66 % (n = 60) chez les non-dialysés et de 70,58 % (n = 84) chez les hémodialysés. Celle de l'anémie par carence en fer absolue était plus élevée chez les non-dialysés (48,33 % ; n = 29), alors que la carence fonctionnelle était plus élevée chez les hémodialysés (34,52 % ; n = 29). La prévalence de la malnutrition par le score de malnutrition et d'inflammation était relativement faible. Seule la carence en fer fonctionnelle était associée à la malnutrition. La prévalence de l'anémie été plus importante chez les patients en insuffisance rénale chronique (non-dialysés et hémodialysés) algérois, contrairement à la malnutrition qui reste associée à l'anémie avec carence en fer fonctionnelle. In chronic kidney disease, anemia and malnutrition coupled with inflammation as malnutrition-inflammation complex syndrom are common and considered as morbidity-mortality factors. The link between these two factors has been described at length in the literature highlighting an association of malnutrition with iron deficiency considered itself as one of the causes of anemia in chronic kidney disease (non-dialysis and hemodialysis). Our study aims to know the prevalence of these two factors in a population of chronic kidney disease (non-dialysis and hemodialysis) of Algiers and to highlight the possible associations between them. This is a multicentre, cross-sectional and descriptive study carried out over a period of 6 months (August 2018 to January 2019). Anemia and malnutrition were assessed by various biological and clinical tools such as the malnutrition inflammation score and the International Society of Renal Nutrition and Metabolism criteria. Statistical tests were performed on the R studio software, considering P < 0.05 as a statistically significant value. Two hundred and nine patients on chronic kidney disease were included (90 non dialysis and 119 hemodialysis). The median age was 70 (IQR = 16) for non dialysis and 56 (IQR = 16.5) for hemodialysis. The prevalence of anemia was 66.66% (n = 60) in non dialysis and 70.58% (n = 84) in hemodialysis. Absolute iron deficiency anemia was higher in non dialysis (48.33%; n = 29) while functional iron deficiency anemia was higher in hemodialysis (34.52%; n = 29). The prevalence of malnutrition by malnutrition inflammation score was relatively low. Only functional iron deficiency anemia was associated with malnutrition. The prevalence of anemia was higher in Algerian chronic kidney disease (non-dialysis and hemodialysis) unlike malnutrition which remains associated with functional iron deficiency anemia. [ABSTRACT FROM AUTHOR]

Résumé: La carence martiale est une complication très fréquente chez les patients atteints d'un cancer digestif, notamment en cas de chimiothérapie, favorisant l'apparition d'une anémie. Les conséquences néfastes sont alors nombreuses, comme la fatigue, l'altération des phanères, les troubles de l'humeur, à l'origine d'une altération significative de la qualité de vie. Pourtant, la carence martiale est sous-diagnostiquée et sous-traitée en oncologie. Tout patient avec une tumeur digestive devrait bénéficier au minimum d'un dosage de la ferritinémie et du coefficient de saturation de la transferrine, permettant d'identifier la carence fer et son évolution après traitement. Il est recommandé de prescrire une supplémentation martiale intraveineuse en cas de carence martiale absolue, mais aussi de carence martiale fonctionnelle associée à une anémie. Dans ce cas, on y associera un agent stimulant l'érythropoïèse. Le fer injectable permet une augmentation du taux d'hémoglobine, une amélioration de la qualité de vie, ainsi qu'une réduction du recours à la transfusion, avec une excellente tolérance. Même s'il est démontré chez les insuffisants cardiaques que le traitement d'une carence en fer sans anémie est bénéfique, les études prospectives randomisées manquent pour recommander une attitude similaire en cancérologie. Iron deficiency is a very frequent complication in patients with a digestive cancer, especially in those treated with chemotherapy, promoting anemia. Negative consequences are numerous, leading to fatigue, alteration of skin appendages, mood disorders, with significant alteration of quality of life. However, iron deficiency is underdiagnosed and undertreated in oncology. Each patient with a digestive tumor should have at least serum ferritin and transferrin saturation dosages, for identifying iron deficiency and its evolution after treatment. It is recommended to prescribe intravenous iron supplementation in case of absolute iron deficiency, but also in case of functional iron deficiency associated to anemia. In this situation, erythropoiesis-stimulating agents is also required. Injectable iron allows the increase of hemoglobin level, improvement of quality of life, and reduction of red blood cells transfusions, with excellent tolerance. Although it is demonstrated that treating iron deficiency without anemia in chronic heart failure patients is useful, randomized prospective studies are lacking for recommending a similar approach in oncology. [ABSTRACT FROM AUTHOR]

Copyright of Archives of Cardiovascular Diseases is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the relationship between prenatal geophagy, maternal prenatal haematological indices, malaria, helminth infections and cognitive and motor development among offspring.Methods: At least a year after delivery, 552 of 863 HIV-negative mothers with singleton births who completed a clinical trial comparing the efficacy of sulfadoxine-pyrimethamine and mefloquine during pregnancy in Allada, Benin, responded to a nutrition questionnaire including their geophagous habits during pregnancy. During the clinical trial, helminth infection, malaria, haemoglobin and ferritin concentrations were assessed at 1st and 2nd antenatal care visits (ANV) and at delivery. After the first ANV, women were administered daily iron and folic acid supplements until three what? post-delivery. Singleton children were assessed for cognitive function at age 1 year using the Mullen Scales of Early Learning.Results: The prevalence of geophagy during pregnancy was 31.9%. Pregnant women reporting geophagy were more likely to be anaemic (AOR = 1.9, 95% CI [1.1, 3.4]) at their first ANV if they reported geophagy at the first trimester. Overall, prenatal geophagy was not associated with maternal haematological indices, malaria or helminth infections, but geophagy during the third trimester and throughout pregnancy was associated with poor motor function (AOR = -3.8, 95% CI [-6.9, -0.6]) and increased odds of geophagous behaviour in early childhood, respectively.Conclusions: Prenatal geophagy is not associated with haematological indices in the presence of micronutrient supplementation. However, it may be associated with poor child motor function and infant geophagy. Geophagy should be screened early in pregnancy. [ABSTRACT FROM AUTHOR]

Objective: In 4- to 8-year-old Zambian children (n = 744), we evaluated the effects of adjusting for inflammation (α1-acid glycoprotein >1 g/l), with or without additional adjustment for malaria, on prevalence estimates of iron deficiency (ID) and iron deficiency anaemia (IDA) during low malaria (LowM) and high malaria (HighM) transmission seasons.Methods: To estimate adjustment factors, children were classified as: (i) reference (malaria negative without inflammation), (ii) inflammation without malaria (I), (iii) malaria without inflammation (M) and (iv) inflammation with malaria (IM). We estimated the unadjusted ID or IDA prevalence, and then adjusted for inflammation alone (IDI or IDAI ) or inflammation and malaria (IDIM or IDAIM ).Results: Mean ferritin was 38 (reference), 45 (I), 43 (M) and 54 μg/l (IM) in LowM, increasing to 44, 56, 96 and 167 μg/l, respectively, in HighM. Corresponding mean sTfR was 6.4, 6.9, 7.9 and 8.4 mg/l in LowM, increasing to 8.2, 9.2. 8.7 and 9.7 mg/l in HighM. Ferritin-based ID, IDI and IDIM were 7.8%, 8.7% or 9.1%, respectively, in LowM and 4.6%, 10.0% or 11.7%, respectively, in HighM. Corresponding soluble transferrin receptor (sTfR)-based estimates were 27.0%, 24.1% and 19.1%, respectively, in LowM, increasing to 53.6%, 46.5% and 45.3%, respectively, in HighM. Additional adjustment for malaria resulted in a ~1- to 2-percentage point change in IDA, depending on biomarker and season.Conclusions: In this population, malaria substantially increased ferritin and sTfR concentrations, with modest effects on ID and IDA prevalence estimates. [ABSTRACT FROM AUTHOR]

The prevalence of anemia in inflammatory intestinal diseases is estimated in more than 60% of patients at diagnosis and 30-40% of cases during follow-up. The prevalence of iron deficiency in inflammatory diseases is estimated at 45%. Iron deficiency causes relatively insidious symptoms, such as chronic fatigue, sleep disorders. In addition to deficiency anemia, inflammation causes iron sequestration in macrophages. This deficiency in iron causes anemia characterized by elevated ferritin levels above 100 mg/L and a reduction in transferrin saturation of less than 20%. In case of iron deficiency anemia, supplementation aims at increasing the concentration of hemoglobin by at least 2 g/dL in 4 weeks. Treatment of inflammatory disease is essential to the management of iron deficiency. A martial deficiency should be sought annually in patients with intestinal inflammatory disease because recurrence is frequent. ECCO's European recommendations (European Crohn's and Colitis Organisation) point out that further intravenous iron supplementation should be considered if ferritin levels fall to less than 100 mg/L or if hemoglobin is less than 12 or 13 g/dL, depending on gender. [ABSTRACT FROM AUTHOR]

Aim: The aim of this study was to investigate iron deficiency anemia and Vitamin D deficiency among autism children and to assess the importance of risk factors (determinants). Subjects and Methods: This was a case-control study conducted among children suffering from autism at the Hamad Medical Corporation in Qatar. A total of 308 cases and equal number of controls were enrolled. The Autism Diagnostic Observation Schedule-Generic was the instrument used for diagnosis of Autism. Results: The mean age (±standard deviation, in years) for autistic versus control children was 5.39 ± 1.66 versus 5.62 ± 1.81, respectively. The mean value of serum iron levels in autistic children was severely reduced and significantly lower than in control children (74.13 ± 21.61 µg/dL with a median 74 in autistic children 87.59 ± 23.36 µg/dL in controls) (P = 0.003). Similarly, the study revealed that Vitamin D deficiency was considerably more common among autistic children (18.79 ± 8.35 ng/mL) as compared to healthy children (22.18 ± 9.00 ng/mL) (P = 0.004). Finally, mean values of hemoglobin, ferritin, magnesium; potassium, calcium; phosphorous; glucose, alkaline phosphate, hematocrit, white blood cell, and mean corpuscular volume were all statistically significantly higher in healthy control children as compared to autistic children (P < 0.001). Multivariate logistic regression analysis revealed that serum iron deficiency, serum calcium levels, serum Vitamin D levels; ferritin, reduced physical activity; child order, body mass index percentiles, and parental consanguinity can all be considered strong predictors and major factors associated with autism spectrum disorders. Conclusion: This study suggests that deficiency of iron and Vitamin D as well as anemia were more common in autistic compared to control children. [ABSTRACT FROM AUTHOR]

Résumé La prévention de l’anémie du donneur de sang est un enjeu essentiel pour la sécurité du donneur mais aussi pour l’autosuffisance quantitative et qualitative en produits sanguins labiles. Cette prévention repose, d’une part, sur l’ajournement des donneurs dont le taux d’hémoglobine est en dessous du seuil réglementaire, et d’autre part, sur la prévention de la carence en fer. Des populations de donneurs sont plus à risque de carence en fer et des conséquences cliniques de cette carence : les femmes en âge de procréer ; les donneurs dont le taux d’hémoglobine est juste au-dessus du seuil d’éligibilité et ceux qui donnent fréquemment. Plusieurs mesures peuvent être utilisées : l’accroissement de l’intervalle minimal entre deux dons de ST et/ou la réduction de la fréquence annuelle maximale de dons ; le dosage de la ferritine sérique mesurant les réserves en fer et enfin la supplémentation en fer des donneurs. The prevention of anemia of blood donor is a main issue for donor safety and self-supplying. This prevention is done in one hand by donor deferral whose haemoglobin level is under defined threshold and in other hand by preventing iron deficiency. Some subgroups of donors are at increased risk for developing iron deficiency and adverse effects of iron deficiency: premenopausal females; donors with haemoglobin values near the minimum for eligibility and frequent donors. Different interventions could be used: lengthening the inter-donational interval and/or decreasing the number of donations per year; donor ferritin testing to evaluate iron store and at least donor iron supplementation. [ABSTRACT FROM AUTHOR]

Copyright of Canadian Journal of Plant Science is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

INTRODUCTION: en République Démocratique du Congo (RDC), plus d'un million de don de sang ont été réalisés entre 2007 et 2011. Cependant, aucun bilan portant sur la carence en fer et l'anémie ferriprive, conséquence d'un don de sang chez les donneurs de sang (DS), n'est disponible dans ce pays. L'objectif de cette étude étaitdestimer la prévalence de la carence en fer, de l'anémie et de l'anémie ferriprive chezles DS au Centre National de Transfusion Sanguine (CNTS) à Kinshasa en RDC. METHODES: entre Décembre 2012 et Août 2013, une étude transversale a été menée au CNTS où des DS éligibles au don de sang ont été inclus. Les informations socio démographiques et des prélèvements sanguins ont été collectés de manière simultanée au don de sang. La ferritine sérique a été dosée pour évaluer la carence en fer en utilisant la technique ELISA. L'hémogramme a été réalisé en vue d'évaluer et mettre au point l'anémie. RESULTATS: au total 386 DS ont été inclus dans cette étude. La prévalence de la carence en fer et de l'anémie ferriprive étaient respectivement de 63,2% (244/386) et 25,9% (100/386) des DS. Une anémie a été trouvée chez 36.5% (141/386) au moment du don de sang. CONCLUSION: la carence en fer, l'anémie et l'anémie ferriprive demeurent très fréquentes chez les DS à Kinshasa. Ces résultats suggèrent la révision des tests biologiques utilisés dans le recrutement des DS au CNTS. Par ailleurs le dosage de la ferritine s'impose en routine chez les DS réguliers à Kinshasa.

Copyright of Pan African Medical Journal is the property of Pan African Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objectives Haematological parameters differ between individuals of African and European ancestry. However, respective data of first-generation African migrants are virtually absent. We assessed these in Ghanaian migrants living in Berlin, compared them with reference data from Germany and Ghana, and estimated the role of iron deficiency ( ID) and erythrocyte polymorphisms in anaemia. Methods A total of 576 Ghanaians (median age, 45 years) were analysed. Blood counts were performed, haemoglobinopathies and glucose-6-phosphate dehydrogenase ( G6 PD) deficiency were genotyped, and concentrations of ferritin and C-reactive protein were measured to define ID. Results Most individuals had resided in Germany for more than a decade (median, 18 years). By WHO definition, anaemia was present in 30.9% of females and 9.4% of males. Median haemoglobin ( Hb) levels were lower than among Germans (women, −0.8 g/dl, men, −0.7 g/dl). However, applying reference values from Ghana, only 1.9% of the migrants were considered anaemic. Alpha-thalassaemia, Hb variants and G6 PD deficiency were observed in 33.9%, 28.3% and 23.6%, respectively. ID was highly prevalent in women (32.0%; men, 3.9%). The population fraction of anaemia cases attributable to ID was 29.0% (alpha-thalassaemia, 13.6%; G6 PD deficiency, 13.5%). Nevertheless, excluding ID, alpha-thalassaemia, G6 PD deficiency and sickle cell disease, anaemia prevalence remained high (women, 18.4%; men, 6.5%), and was also high when applying uncensored thresholds proposed for African Americans (females, 19.3%; males, 7.8%). Conclusions Iron deficiency and erythrocyte polymorphisms are common among first-generation Ghanaian migrants but explain only part of the increased prevalence of anaemia. Common Hb thresholds for the definition of anaemia may not be appropriate for this group. [ABSTRACT FROM AUTHOR]

Résumé L’anémie par carence martiale reste encore une problème mondial. Le déficit en fer sans anémie est souvent sous-diagnostiqué. Dans cette étude, nous faisons une revue des symptômes et syndromes associés à un déficit en fer avec ou sans anémie : fatigue, fonctions cognitive, syndrome des jambes sans repos, perte de cheveux, et insuffisance cardiaque chronique. Le fer est absorbé au niveau du tube digestif. L’hepcidine et la ferroportine sont les principales protéines de régulation de l’absorption du fer. Des micro-organismes pathogènes ou la dysbiose intestinale pourraient avoir un rôle sur l’absorption de fer. Iron deficiency anemia still remains problematic worldwide. Iron deficiency without anemia is often undiagnosed. We reviewed, in this study, symptoms and syndromes associated with iron deficiency with or without anemia: fatigue, cognitive functions, restless legs syndrome, hair loss, and chronic heart failure. Iron is absorbed through the digestive tract. Hepcidin and ferroportin are the main proteins of iron regulation. Pathogenic micro-organisms or intestinal dysbiosis are suspected to influence iron absorption. [ABSTRACT FROM AUTHOR]

Copyright of Revue Francophone des Laboratoires is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The article looks at a study about the mineral element concentrations in Sakiz crossbred lambs with pica disorder. It aims to specifically determine the serium calcium, phosphorus, magnesium, copper, zinc and iron concentrations in the lambs and prove the efficiency of mineral preparation as treatment. After the blood samples were taken from the 25 lambs, it was found that the mineral concentrations do not have significant differences between affected and healthy lambs. However, there was a marked decline of iron concentration in all animals with pica. Conclusion suggests that iron deficiency affects the aetiology of pica and confirms the benefits of mineral element supplementation for lambs with pica.

Copyright of Revue Francophone des Laboratoires is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Iron starvation and oxidative stress are 2 hurdles that bacteria must overcome to establish an infection. Pathogenic bacteria have developed many strategies to efficiently infect a broad range of hosts, including humans. The best characterized systems make use of regulatory proteins to sense the environment and adapt accordingly. For example, iron-sulfur clusters are critical for sensing the level and redox state of intracellular iron. The regulatory small RNA (sRNA) RyhB has recently been shown to play a central role in adaptation to iron starvation, while the sRNA OxyS coordinates cellular response to oxidative stress. These regulatory sRNAs are well conserved in many bacteria and have been shown to be essential for establishing a successful infection. An overview of the different strategies used by bacteria to cope with iron starvation and oxidative stress is presented here. La carence en fer et le stress oxydatif sont deux obstacles que les bactéries doivent franchir pour provoquer une infection. Par conséquent, les bactéries pathogènes ont développé des stratégies pour infecter efficacement une vaste gamme d’hôtes, y compris l’humain. Les systèmes les mieux caractérisés font appel à des protéines régulatrices pour sonder l’environnement et s’adapter en conséquence. Par exemple, les groupements fer-soufre sont importants pour détecter le taux de fer intracellulaire et l’état redox. Au cours des dernières années cependant, des travaux ont démontré que de petits ARN régulateurs jouent des rôles clés dans l’adaptation à ces stress. Plus spécifiquement, RyhB joue un rôle central dans l’adaptation à la carence en fer, alors que OxyS coordonne la réponse cellulaire au stress oxydatif. Comme on peut s’y attendre, ces petits ARN régulateurs sont bien conservés dans de nombreuses bactéries, et il s’est avéré que leur présence était essentielle pour provoquer une infection réussie. Nous présentons ici diverses stratégies utilisées par les bactéries pour s’ajuster à la carence en fer et au stress oxydatif. [ABSTRACT FROM AUTHOR]

Iron deficiency (ID) without anaemia frequently remains undiagnosed when symptoms are attributed to ID with anaemia. Serum ferritin is the primary diagnostic parameter, whereas < 10 µg/l represent depleted iron stores, 10-30 µg/l can confirm ID without anaemia and 30-50 µg/l might indicate functional ID. In case of increased CRP or ALT, normal/elevated ferritin should be interpreted with caution. Intravenous iron is indicated if oral iron is not effective or tolerated. At ferritin <10 µg/l, a cumulative dose of 1000 mg iron and at ferritin 10-30 µg/l, a cumulative dose of 500 mg is advised. At ferritin 30-50 µg/l a first dose of 200 mg might be considered. Ferritin shall be reassessed not sooner than 2 weeks after the last oral or 8-12 weeks after the last iv iron administration. [ABSTRACT FROM AUTHOR]

Anemia is a common problem in family medicine and therefore frequently investigated in general practice. Anemias are classified according to mean corpuscular volume (MCV) and reticulocyte count. An algorithm for the evaluation of the cause contains patients history and laboratory analysis including reticulocyte count, serum ferritin and CRP, serum vitamin B12, serum or erythrocyte folate and serum creatinine. Therewith most anemias in general practice can be explained. The most important types of anemia, e.g. iron deficiency anemia, are discussed as well as aspects of diagnosis and therapy. Iron deficiency anemia is often diagnosed together with other types of anemia, such as e.g. anemia of chronic disease. Particular aspects of anemia in the elderly as well as renal anemia are discussed. [ABSTRACT FROM AUTHOR]

Copyright of Revue Francophone des Laboratoires is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Summary: Objective: The anemic status may alter brain functions and electrogenesis, as reflected by EEG and cognitive EPs (CEPs). This study aims to evaluate CEPs and EEG power spectra in adult patients with iron-deficiency anemia and to determine the effects of appropriate iron therapy on electrodiagnostic findings. Methods: Fifty-one patients with iron-deficiency anemia underwent CEP and EEG recording. All patients were re-assessed after three months of oral-iron therapy. Results: All patients had recovered from their anemia through the three-month iron therapy. Central N1 amplitude and parietal P2 amplitude was increased. N2 latencies were shortened in frontal and central regions. P3 latencies were shortened in frontal, central and parietal areas and P3 amplitude was increased in the parietal region. Except in the gamma-band, all pretreatment and post-treatment mean-power values were significantly lower at the temporal, parietal and occipital regions. Conclusions: This study indicates that in iron-deficiency anemia, appropriate iron therapy can improve brain electrogenesis, as reflected by P300 and EEG power spectra. [Copyright &y& Elsevier]

Abstract: Objectives: To determine the prevalence of iron deficiency and anaemia and to identify their nondietary determinants among orphans and vulnerable children from Burkina-Faso. Methods: Biochemical indicators of iron status were measured for 61 children, aged one to six years. Participants were also screened for infections (malaria and intestinal parasites) and hemoglobinopathies. Multiple regression analyses were used to identify the main risk factors for iron status. Results: Anaemia (haemoglobin inferior than 100g/l for the 12–59 months old children and inferior than 105g/l for the five to six years) affected 60% of children, whereas 83% had depleted iron store (SF<30μg/l). The quasi-totality of children (93%) had iron deficiency measured by a multiple biochemical index model. Nearly 45% of participants were suffering from iron deficiency anaemia, representing three-quarters of the cases of anaemia. Malaria, intestinal parasitosis and hemoglobinopathies were found in 7, 78 and 24% of children respectively. Multiple regression analyses suggested that stunting, infection (Entamoeba coli), female gender, recent diarrhoea and lack of biological relation with caregiver were negative predictors of haemoglobin concentration. The most important predictors of serum ferritin were inflammation, orphan status, stunting and recent diarrhoea. Conclusions: These findings suggest that infection and protein-energy malnutrition significantly contributed to iron deficiency. An intervention aiming to improving iron nutrition of these disadvantaged children should simultaneously target on intakes of bioavailable iron and energy and prevention of infection. [Copyright &y& Elsevier]

Copyright of Revue Francophone des Laboratoires is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In chronic kidney disease, anemia and malnutrition coupled with inflammation as malnutrition-inflammation complex syndrom are common and considered as morbidity-mortality factors. The link between these two factors has been described at length in the literature highlighting an association of malnutrition with iron deficiency considered itself as one of the causes of anemia in chronic kidney disease (non-dialysis and hemodialysis). Our study aims to know the prevalence of these two factors in a population of chronic kidney disease (non-dialysis and hemodialysis) of Algiers and to highlight the possible associations between them., Patients and Methods: This is a multicentre, cross-sectional and descriptive study carried out over a period of 6months (August 2018 to January 2019). Anemia and malnutrition were assessed by various biological and clinical tools such as the malnutrition inflammation score and the International Society of Renal Nutrition and Metabolism criteria. Statistical tests were performed on the R studio software, considering P<0.05 as a statistically significant value., Results: Two hundred and nine patients on chronic kidney disease were included (90 non dialysis and 119 hemodialysis). The median age was 70 (IQR=16) for non dialysis and 56 (IQR=16.5) for hemodialysis. The prevalence of anemia was 66.66% (n=60) in non dialysis and 70.58% (n=84) in hemodialysis. Absolute iron deficiency anemia was higher in non dialysis (48.33%; n=29) while functional iron deficiency anemia was higher in hemodialysis (34.52%; n=29). The prevalence of malnutrition by malnutrition inflammation score was relatively low. Only functional iron deficiency anemia was associated with malnutrition., Conclusion: The prevalence of anemia was higher in Algerian chronic kidney disease (non-dialysis and hemodialysis) unlike malnutrition which remains associated with functional iron deficiency anemia., (Copyright © 2022 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.)

Piglets, especially weaning piglets, show a lower level of immunity and higher morbidity and mortality, owing to their rapid growth, physiological immaturity, and gradual reduction of maternal antibodies, which seriously affects their growth and thus, value. It is important that piglets adapt to nutrient digestion and absorption and develop sound intestinal function and colonization with gut microbiota as soon as possible during their early life stage. Lactoferrin is a natural glycoprotein polypeptide that is part of the transferrin family. It is widely found in mucosal secretions such as saliva and tears, and most highly in milk and colostrum. As a multifunctional bioactive protein and a recommended food additive, lactoferrin is a potential alternative therapy to antibiotics and health promoting additive for piglet nutrition and development. It is expected that lactoferrin, as a natural food additive, could play an important role in maintaining pig health and development. This review examines the following known beneficial effects of lactoferrin: improves the digestion and capacity for absorption in the intestinal tract; promotes the absorption of iron and reduces the incidence of iron deficiency anemia; regulates intestinal function and helps to balance the microbial biota; and enhances the resistance to disease of the piglets via modulating and enhancing the immune system.

The long-term decay rate of serum ferritin post-iron infusion in athletic populations is currently unknown. Here, we modelled the decay rate of serum ferritin in female athletes after an intravenous iron infusion ( n = 22). The post-infusion serum ferritin response and the rate of decay was highly variable between athletes; however, we demonstrate that follow-up blood testing at 1 (154 μg/L; 77-300 μg/L) and 6 months (107 μg/L; 54-208 μg/L) post-infusion is appropriate to observe treatment efficacy and effectiveness. Novelty Female athletes should have serum ferritin assessed at 1 and 6 months following an intravenous iron infusion to determine efficacy and effectiveness.