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349 results on '"C. Dirk Keene"'

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1. Evidence of mutant huntingtin and tau-related pathology within neuronal grafts in Huntington’s disease cases

2. Mapping human tissues with highly multiplexed RNA in situ hybridization

3. Assessing translational applicability of perineuronal net dysfunction in Alzheimer’s disease across species

4. Advancements in high-resolution 3D microscopy analysis of endosomal morphology in postmortem Alzheimer’s disease brains

5. Cross-species comparative analysis of single presynapses

6. Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer’s disease

7. A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer’s disease

8. INTER-INDIVIDUAL VARIATION IN HUMAN CORTICAL CELL TYPE ABUNDANCE AND EXPRESSION

9. WHOLE BRAIN SINGLE NUCLEUS TRANSCRIPTOMICS IN HUMAN: WHAT WE KNOW SO FAR

10. Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

11. A single-cell based precision medicine approach using glioblastoma patient-specific models

12. Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration

13. Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change

14. Adipocyte-Derived Small Extracellular Vesicles from Patients with Alzheimer Disease Carry miRNAs Predicted to Target the CREB Signaling Pathway in Neurons

15. Multispectral LEDs Eliminate Lipofuscin-Associated Autofluorescence for Immunohistochemistry and CD44 Variant Detection by in Situ Hybridization in Aging Human, non-Human Primate, and Murine Brain

16. Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease

17. Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease

18. TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans

19. COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI)

20. The microvascular extracellular matrix in brains with Alzheimer’s disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA)

21. Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury

22. Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer’s disease pathology: a clinicopathological study

23. Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

24. Leveraging Neuroimaging Tools to Assess Precision and Accuracy in an Alzheimer’s Disease Neuropathologic Sampling Protocol

25. A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease

26. Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort

27. The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample

28. Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

29. Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.

30. Longitudinal cognitive performance of Alzheimer's disease neuropathological subtypes

31. Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer’s Disease Brain

32. Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

33. MaPPeRTrac: A Massively Parallel, Portable, and Reproducible Tractography Pipeline.

34. Neural Differentiation and Incorporation of Bone Marrow-Derived Multipotent Adult Progenitor Cells after Single Cell Transplantation into Blastocyst Stage Mouse Embryos

35. Differential Vulnerability of Hippocampal Subfields in Primary Age-Related Tauopathy and Chronic Traumatic Encephalopathy

36. Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer’s disease neuropathologic change

37. Human microglia show unique transcriptional changes in Alzheimer’s disease

38. Performance of a condensed protocol to assess limbic-predominant age-related TDP-43 encephalopathy neuropathologic change

39. Integrated multimodal cell atlas of Alzheimer’s disease

41. Supplementary Information from Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis

42. Association of cerebral microvascular dysfunction and white matter injury in Alzheimer’s disease

43. Sex differences in the genetic architecture of cognitive resilience to Alzheimer’s disease

44. New insights into the genetic etiology of Alzheimer's disease and related dementias

45. Data from Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis

46. Tau–RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change

47. Pontine pathology mediates common symptoms of blast-induced chronic mild traumatic brain injury

48. The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia

49. Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis

50. Spinal cord‐predominant neuropathology in an adult‐onset case of <scp> POLR3A </scp> ‐related spastic ataxia

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